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<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZM6</accession>
    <name>A0A1W1HZM6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46206">
        <property type="protein sequence ID" value="SLM46206"/>
        <property type="gene ID" value="NSJP_0034"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0034"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012348139" evidence="1">
        <location>
            <begin position="22"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="185" mass="20320" checksum="D8E018081609D1C9" modified="2017-06-07" version="1">MHAFLVFVLAALLCVASPLSAQTPCASCLNTVEEGLRACLGNAFSSEDRVACEDKRQAQMQACVAGECKVERDEQAVRERRSEPQVPKRSGLTPYTPTSIEWLALTANAQLQEQASADRPYSLHVVEADPETLAIVVRHQPGASREQMARSIATARQVIMSTAKRHGWDAWVKIQERVEPVPAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZN3</accession>
    <name>A0A1W1HZN3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46205">
        <property type="protein sequence ID" value="SLM46205"/>
        <property type="gene ID" value="NSJP_0033"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0033"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="131" mass="14884" checksum="6C97675050CE5495" modified="2017-06-07" version="1">MPGSPRHLDQQTSLLSRQHHALRLSTGPQRYLIYRYRGGVSRGGFEGQRLNPLMADKPVSICKTSLNILTFQPRISKQNRIECVTCSEHAENMLNSKPATSHNRLTTEYFRVDCNPLKQKLLIHSSPRVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZT6</accession>
    <name>A0A1W1HZT6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP pyrophosphokinase</fullName>
            <ecNumber evidence="5">2.7.6.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">relA</name>
        <name evidence="5" type="ORF">NSJP_0094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the relA/spoT family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0094"/>
    <dbReference type="EnsemblBacteria" id="SLM46266">
        <property type="protein sequence ID" value="SLM46266"/>
        <property type="gene ID" value="NSJP_0094"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0094"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="3">
        <location>
            <begin position="50"/>
            <end position="149"/>
        </location>
    </feature>
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            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="2">
        <location>
            <begin position="643"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="722" mass="81394" checksum="A4FB47085D5E7F0E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I036</accession>
    <name>A0A1W1I036_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46249">
        <property type="protein sequence ID" value="SLM46249"/>
        <property type="gene ID" value="NSJP_0077"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0077"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="191" mass="21341" checksum="DD74F65C233B5F19" modified="2017-06-07" version="1">MAQSSTPSDYLSLGRQLAILLGSSLEGRSGDALKELARAYDPSANDARVSAEVFLFHKYLVVQSCVGMFPESEVERVIGGLFAALNEKATRLEFSQERQQAMEQMWQMRARQFDAPFTEDREHFVQQAQDGVYWKHSLSRFCQNVLELENPPDIWAGGKGPSHKASAAVTEAVEQLVAAMREMSRLHFGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0D2</accession>
    <name>A0A1W1I0D2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhiI</name>
        <name evidence="2" type="ORF">NSJP_0284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46456">
        <property type="protein sequence ID" value="SLM46456"/>
        <property type="gene ID" value="NSJP_0284"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0284"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="1">
        <location>
            <begin position="49"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="351" mass="37464" checksum="FBC97B0E16E34DC5" modified="2017-06-07" version="1">MAVKLSKKWIVVAIVVAGGGVLGYQHWKSMQSALPPGIVSGNGRIEATLVDASAKEPLRVKKILVKEGDLVKQGDVLVQLDTVTLEAELAKEKASMAGAKHELAAAKSSVAQQQARIRLAQIEERRDRKLLEGDAVSQREYDVSKAALDSATATLSAAQAGVAAAQAQIEVTQASVAKTESRIRDATLVSPTAGRVLYRLVEPGEVLGPGGKALTIVDLSNVYMELFLPAEHAAALKVGAEARITVDYNPTRSAIAYVSFVSPEAQFTPKQVETKSEREKLMFRVKIQVPPDLVEQYIERIKTGIRGVGYVKLSDAAVWPAWLQKDVVNLPKSGSAQPAAPTAPEAAATSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0H6</accession>
    <name>A0A1W1I0H6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46510">
        <property type="protein sequence ID" value="SLM46510"/>
        <property type="gene ID" value="NSJP_0338"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0338"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="123" mass="12387" checksum="6AC9B2D70D12C63F" modified="2017-06-07" version="1">MPTTFALNCSSRLQLSSATCFAPGVALAGIIARQLRKVSVWTDLAAASAVANFGAVPAALEAAGAELGAAAGAELGVLPAVAPFPEPVVPSLAQPPAINPKNAANTMALCSEMRMPLSSLMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0R0</accession>
    <name>A0A1W1I0R0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein NorQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">norQ</name>
        <name evidence="4" type="ORF">NSJP_0418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbbQ/NirQ/NorQ/GpvN family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0418"/>
    <dbReference type="EnsemblBacteria" id="SLM46590">
        <property type="protein sequence ID" value="SLM46590"/>
        <property type="gene ID" value="NSJP_0418"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0418"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013615">
        <property type="entry name" value="CbbQ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08406">
        <property type="entry name" value="CbbQ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="2">
        <location>
            <begin position="44"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="CbbQ_C" evidence="3">
        <location>
            <begin position="191"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="276" mass="30748" checksum="7784EB304B7250F9" modified="2017-06-07" version="1">MGKNVTEPAHEIDIGRYRVAEEPYYANVRGEVELFLTAAKCRMPVMLKGPTGCGKTRFVRHMAHRLNRPLITVACHEDLTASDLVGRYLLKGQETVWIDGPLTLGVKHGAIVYLDEVVEARKDTTVIIHPLSDDRRLLPIEKKGQIIEAAEDFLLVISYNPGYQSVLKDLKPSTKQRFMAIEFDYPAAAVETEIVRREAGVEYEVAGKLVKLGAKVRNLKNHGLEEGVSTRLLIYAATLIREGIPVDQACDVAVARPVTDDADMQRSILELVKAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0W7</accession>
    <name>A0A1W1I0W7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjdF</name>
        <name evidence="2" type="ORF">NSJP_0459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46631">
        <property type="protein sequence ID" value="SLM46631"/>
        <property type="gene ID" value="NSJP_0459"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0459"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014509">
        <property type="entry name" value="UCP020606"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09997">
        <property type="entry name" value="DUF2238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020606">
        <property type="entry name" value="UCP020606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="213" mass="23582" checksum="656CE8EC02136B61" modified="2017-06-07" version="1">MGKRPRVILWLSVWYGLLWTGLAVSPYDRQDWLLENLLALTAVTMLIVTYRRFQFSSLSYVLITTFLSLHAVGAHYTYAEVPFGFWLQQVFGLSRNPYDRLVHFSYGLLLVFPLREVLVRLAGVAGVWSYYLPVSGMLAQSGFFEVVEAIVAEIVSPDLGAAYLGMQGDPWDAQKDMAAALVGAVATMLIVAVATRSSGPEARRAGRRTIANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0X5</accession>
    <name>A0A1W1I0X5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HflC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hflC</name>
        <name evidence="4" type="ORF">NSJP_0470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">HflC and HflK could regulate a protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the band 7/mec-2 family. HflC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0470"/>
    <dbReference type="EnsemblBacteria" id="SLM46642">
        <property type="protein sequence ID" value="SLM46642"/>
        <property type="gene ID" value="NSJP_0470"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0470"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052547">
        <property type="term" value="P:regulation of peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03405">
        <property type="entry name" value="SPFH_HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010200">
        <property type="entry name" value="HflC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42911">
        <property type="entry name" value="PTHR42911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005651">
        <property type="entry name" value="HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01932">
        <property type="entry name" value="hflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="23"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="286" mass="32841" checksum="E5FC2141A8E6E8CD" modified="2017-06-07" version="1">MSKQGLTIAVLAVLFALFVLGASPLFVVDVTQTAIVVQLGKPIRTVTEPGLYVKVPFAQEVTYFDKRLLDYDSDAQDVITQDKKTLLLDNFAKWRITDPLKVYQNFQSQRGALQRLHDIIYSELRVELGRHDLAEIVSTARAELMKVVTQRANEKASAYGIAIQDVRIKRADLPQENEKTVFQRMQAEREQQAKQYRAEGAEEAQKIRSDAEKDKEILLAQAYKESEEIRGEGDAKAFRIYADAYRQDPKFFDFTRSMEAYKKSLDDKTTLVLSPDSEFFHYLKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I100</accession>
    <name>A0A1W1I100_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0351"/>
    <dbReference type="EnsemblBacteria" id="SLM46523">
        <property type="protein sequence ID" value="SLM46523"/>
        <property type="gene ID" value="NSJP_0351"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0351"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012935631" evidence="1">
        <location>
            <begin position="27"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="510" mass="56116" checksum="F7DB840B320331BA" modified="2017-06-07" version="1">MKPSGMRRHWAVVAFLILTMGLQSCAPTKLPLNTSVPAMKVRKFPVSAAVVIPETVRNGVSTYDVSCAGNYEIPIGAELEAGIGETLSPIFDTVDVVTDKGLAVGHYDVVVEPKPLQLTTDGHCLSRRFLYLLGPFYIFTNPTDSFDATAEVPVTVMDRQGQTILTDTFKSKTHNKDALFQTAADKDSAVRIVLREAVIDALQQLSRGLANSPQMVSYARTAPKRPADRAQASVVRTERSSDVDILPQVAVKPQKTRFAVIIGIEQYRQNLPPVEFASHDAYIMREYLTKTLGYPDENVVLVVNERAAKSDLEKYIERWLPNRVDKDSSVLIYYSGHGAPNPTTQEGFLVPYDGDPTFLEITGYPLKRLYEQLAKLPAREILVVLDSCFSGSGGRSVIAKGARPLVVSMENPVLTGDRVVVLTASSASQISSTYDQKSHGLFTYFFLKGLQGAADTNKDGTIDLSELYAYVKPEVERVARREYNNDQVPQLIGSPEILKRGVQLLDRGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I150</accession>
    <name>A0A1W1I150_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-methylcitrate dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prpD</name>
        <name evidence="4" type="ORF">NSJP_0556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.79" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0556"/>
    <dbReference type="EnsemblBacteria" id="SLM46728">
        <property type="protein sequence ID" value="SLM46728"/>
        <property type="gene ID" value="NSJP_0556"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0556"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="PTHR16943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE_PrpD" evidence="2">
        <location>
            <begin position="29"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE_PrpD_C" evidence="3">
        <location>
            <begin position="298"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="494" mass="54224" checksum="DBFAD1C58E11295F" modified="2017-06-07" version="1">MISQLREVQRMKIEEGIHIGKERPLLADRLARYSRTLRYEDLPGAVVHEVKRRIMDSLGCALGAWNAPPCRIARRIAESVKVAGGTTLWGTGHKTLPDLAAFANGAMVRYLDFNDTYLAREPAHPSDNLAAVLAAGEACHASGKSVILAAVVAYEVQCRLCDAAALRPRGWDHVTYGPFSSALGAAKVMKLSASKTEQAVNLAGVANVALRQTRVGDLSMWKACAFSNAARNGVFAATLARSGMTGPAPIFEGEKGFMRLVSGPLDLFPFAGEMAQASSMAGSQSPSFKILDTYIKHYPVEYHAQTAVEAALAIREDLLKAEGDGALASISEVEIASYDVAIEIIGRDPEKWRPRTRETADHSFPFCVAATLLDGKMTLRSFDGARLTDPALQALMQKVRVVPQSDFVGRYPEAMPTRLMVRTRAGNVYLQEVDHPLGHPKNPMSDQQVEDKFRLLAEKTLSRERMRTLIRSVWTLDRLRDIGALMPLLRIRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I157</accession>
    <name>A0A1W1I157_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46735">
        <property type="protein sequence ID" value="SLM46735"/>
        <property type="gene ID" value="NSJP_0563"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0563"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="140" mass="15891" checksum="A2E7670C29A604ED" modified="2017-06-07" version="1">MVPMTDIVKPSVQAFLVCDQVIEDSVTKKKSLIGLFTHLQAAAFPFQHQQMGLYFCLTDAEGTYRFDIDLMYLNTEQLVCRATLPNIVIGDRLQISDFGINIPSLIFPAPGRYEFRLRMEGHLIAQKDFNVMQLQPHPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I189</accession>
    <name>A0A1W1I189_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46765">
        <property type="protein sequence ID" value="SLM46765"/>
        <property type="gene ID" value="NSJP_0593"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0593"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="187" mass="21398" checksum="38A1AA2CBB14F98A" modified="2017-06-07" version="1">MGKELPILPASAQPAQAASTEKFLYSRVFCQKENSPPLRLLLEFLKSRGQLPITPPEVDEAALDEWAWVQVSLGYDKARKPIHVFCFRDRGTYKEAFEQDRDQFLEVLTAHDNLEASLVAETLRRSRFVLTTRMDQADITDEGYDFNGWILEFYQENCNGIVEVDDQGFFSPKGELIVDLAPMSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1C8</accession>
    <name>A0A1W1I1C8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46805">
        <property type="protein sequence ID" value="SLM46805"/>
        <property type="gene ID" value="NSJP_0633"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0633"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="67" mass="8011" checksum="A5A1F4B8417C6484" modified="2017-06-07" version="1">MSSSELETTIAELIRLLDQQMDDRALAWFLVWKLYCRYDPSPEQSNREWLKGIVHVFREELKKRGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1K6</accession>
    <name>A0A1W1I1K6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46861">
        <property type="protein sequence ID" value="SLM46861"/>
        <property type="gene ID" value="NSJP_0689"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0689"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="72" mass="8172" checksum="F5BB57E60D73657F" modified="2017-06-07" version="1">MPTRRRPNGCSVLIKLIGIHRFLVPSSSDRTVIAVTIIRGSAIAHDRYQMTWEDAQIIEVDCAVERAQRRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1N8</accession>
    <name>A0A1W1I1N8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_0754</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0754"/>
    <dbReference type="EnsemblBacteria" id="SLM46926">
        <property type="protein sequence ID" value="SLM46926"/>
        <property type="gene ID" value="NSJP_0754"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0754"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="164" mass="17611" checksum="A21D8AD4B66381C4" modified="2017-06-07" version="1">MTTRSAGETDRLGQALGHTLRGGEFLALLGTLGAGKTTLVRGIAKGLDASPSSVSSPTFVLAHEYRGRLVLIHADLYRIRSPHEPESTGLTEYLSGATVAAVEWADKAPGWWPDDRLEIELRHLTVGSRTIRLTAQGPLSTGLLARARTKFSQLATARRKVSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1P4</accession>
    <name>A0A1W1I1P4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46930">
        <property type="protein sequence ID" value="SLM46930"/>
        <property type="gene ID" value="NSJP_0758"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0758"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010730754" evidence="1">
        <location>
            <begin position="27"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="227" mass="24135" checksum="F0A10A69C17D55D8" modified="2017-06-07" version="1">MKFHTKGWAAAAAVASVVSMASAALAIESFQERFEWGDMSKPTTLQGRVIILDPYDEAVWINIAVFGGNAESGLFWQKIHPGKNLKFYADKGAWEELKKMGRPHAGPAAAKEVPPGSTTDLIEFTVTETEQNHRVISAVKKLQETAGAPGKPVSISALRLKDCVGKNEMDASCYAAKQGLNTSPKTPDGATLPMQYDVLLPGGKPVGGLIPWTAKYNLPGSGGGSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1X2</accession>
    <name>A0A1W1I1X2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0651"/>
    <dbReference type="EnsemblBacteria" id="SLM46823">
        <property type="protein sequence ID" value="SLM46823"/>
        <property type="gene ID" value="NSJP_0651"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0651"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.40.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007899">
        <property type="entry name" value="CHAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038186">
        <property type="entry name" value="CHAD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05235">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00880">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51708">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="17"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="CHAD" evidence="2">
        <location>
            <begin position="210"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="491" mass="55642" checksum="3AFDF9FF2A8ABC68" modified="2017-06-07" version="1">MLKVSPPPTSVIPLKSVVETEKKLSVEADFRLPALSGRPLPRRVFTSTYFDTLDHCLARSSITLRRRLDHGSAVWQMKLPPVHGARRELELRESSATPPAQFADALIVLHEGKHLVPIAELRTSRTGVCLLDGKRNRIEVVLDSVSVLRQGSVIQQFKELEIESLHGNDTEIETLASTLYGAGARPHDGRPKLFRALSLACHAPDDSDGDASMLDSIRHGLIRQLDTLKQCDPAVRLCGDMNDVHRIRVAARRMRTLLKAVRKATSPDWTEPLLPGLKWLGDIFALVRNLDVQMEYFRAESEQLKARDRRPLEPFLRHLQSDRELARQRLLSEMRTARYFGFISKLRDAAESPTVTDPKYTFTDAAARQFRTLRKAVRHLNANPSNAELHHVRILTKRARYAAELAQAGDGKGIGRFIKCAARFQDLLGTHQDAVLAERYVEGLLKYQGRRQAAFTAGLLAARAKQRRQEVRAELWSRWKRLKKRGNHTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I225</accession>
    <name>A0A1W1I225_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47058">
        <property type="protein sequence ID" value="SLM47058"/>
        <property type="gene ID" value="NSJP_0886"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0886"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="263" mass="28931" checksum="84C4F2B830FA433B" modified="2017-06-07" version="1">MPRLPILSSVPLLTLCLLSACTSSRGLPVEPLQEILREEADRFEAPSPAPPPRSIHTRPEVPALGLYLKRAGILPHDFEWTDRNRDHVLAWARTLATNGDLSGAQYIPRSSLKGFQLSQLRDSSARYGTDLLLVLDGAGAVDRYNNSKGRWLYWTILGTYFADGTHSDALCLVRGSLWDVKSGAFLFEAQAEGRAHTVGPAAFLDDTTAVEQAKARALENLERMIAEELRRLRKLPQTDGPVIENQSSREPKKTGDSATGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I251</accession>
    <name>A0A1W1I251_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47077">
        <property type="protein sequence ID" value="SLM47077"/>
        <property type="gene ID" value="NSJP_0905"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0905"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012619224" evidence="1">
        <location>
            <begin position="26"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="185" mass="21010" checksum="8FB7E90A27C6B709" modified="2017-06-07" version="1">MRRTSVRPVLALLSLLGLMVFHGSAAGQTGGLDHSPAEIVKKYFQLDQKGARLDSLSFEAIAPFIDWRDEPTWGRIVVIRGFTVAEHYTQWDIVDRLEVVVPVAFQIIGSVYLETAGFVPEAGTEEVRVRVKSVKNRWRIIEPVLPPHVGQKRMLNLVREAWVKEGEQDKRDRLAGLEDELRKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I258</accession>
    <name>A0A1W1I258_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46903">
        <property type="protein sequence ID" value="SLM46903"/>
        <property type="gene ID" value="NSJP_0731"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0731"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="116" mass="13066" checksum="4593CB42BDB9AA6C" modified="2017-06-07" version="1">MPFDKYGQFNSNVGLISFFRSEIVKATMLGQTNFVMEVLILRPLKPSKVAGGVVQCALKVLRHESGAPRFKVCRNPEMCRTYLKFDLMRDEGRGMPSLRFSEARPAYLGTKSESDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2B2</accession>
    <name>A0A1W1I2B2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium transport protein CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">corA</name>
        <name evidence="7" type="ORF">NSJP_0963</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mediates influx of magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47135">
        <property type="protein sequence ID" value="SLM47135"/>
        <property type="gene ID" value="NSJP_0963"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0963"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004488">
        <property type="entry name" value="Mg/Co-transport_prot_CorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00383">
        <property type="entry name" value="corA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="351" mass="39842" checksum="BE5D08E7A7F7A666" modified="2017-06-07" version="1">MKLVQKRSKKSGLAPGTIVHIGEKKSEVVTITTFHYAGGYCEERQVEDPATLAPPTDESVVWINVSGVHRMDVLEAFGKQFGLHPLLLEDIANTDQRPKLDDYDTYLFLVTKMLTLTDNQSVMVEQVSVVLGRNYVLSFQENGTDVFQPVRERLRGGKGRLRQSGADYLCHALIDAIVDQYFAVLEVVGEKIESLQQLVVADPQPETLRDIHALKRQLLFLRRAVWPLRDVMNNLSRSDCPFLQQPTKVFFRDVYDHVVQIVDTIETLREMVSASLDIYLSSVSYRLNSVMRMLTVITTIFMPLSFIASIYGMNFEHMPELRAEWGYPVVLGVMAAVGIAMLVLFRKKGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2D2</accession>
    <name>A0A1W1I2D2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0983</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0983"/>
    <dbReference type="EnsemblBacteria" id="SLM47155">
        <property type="protein sequence ID" value="SLM47155"/>
        <property type="gene ID" value="NSJP_0983"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0983"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="5"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="290" mass="31899" checksum="F5C5993604A04FAA" modified="2017-06-07" version="1">MKPVVVVTGAGGLIGQYLVRTAPRWAPDWEVRGLTRRDLELTQVPAVETMWETLNPHAVIHCAALSRTKDCEQDPGAARLANVLVTTHLSTLSRDVPFIFLSSGEVFDGRRGWYEEADEAVPINVYGRTKLEAERIVLGNPKHSVVRIVLTAGTSAAGDRSFVEDMCRAARAGKDVRLYADEFRCPLPAGAIARAVWDLLGAGRPGLYHLGGSDRLSRWEIGEKLLPYYPVLSGRLIRGSGRDHVGAPRPADLSLCCDKIQTLLSFRLPGFAQWLERRGSDGDPWDYPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2G6</accession>
    <name>A0A1W1I2G6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multidrug efflux system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acrB</name>
        <name evidence="5" type="ORF">NSJP_1038</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1038"/>
    <dbReference type="EnsemblBacteria" id="SLM47210">
        <property type="protein sequence ID" value="SLM47210"/>
        <property type="gene ID" value="NSJP_1038"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1038"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="876"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="900"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="926"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="972"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1007"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1056" mass="115062" checksum="68E98E4677629582" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2I4</accession>
    <name>A0A1W1I2I4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1019"/>
    <dbReference type="EnsemblBacteria" id="SLM47191">
        <property type="protein sequence ID" value="SLM47191"/>
        <property type="gene ID" value="NSJP_1019"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1019"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="213" mass="22903" checksum="DBEF6B6302B8B5D6" modified="2017-06-07" version="1">MKIAVIGATGFAGSAILKEALDRGHEVSAIARHPEKLAPHPKLHLRKGDAYNEDEIAGLVSGHDAVISAFNPGWTNPDIFHQQVRGMKGIINGVKKAGVARLLVVGGAGSLEVKPGVQSVDLPEFPDEYKQGALATREALHLLRNEPTLQWSFLSPSADLSPGARTGVFRLGTDQLLRDANGASRISVEDYAVAMIDELERPAHIRSRFTVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2K8</accession>
    <name>A0A1W1I2K8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47227">
        <property type="protein sequence ID" value="SLM47227"/>
        <property type="gene ID" value="NSJP_1055"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1055"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="91" mass="9986" checksum="4B358C887E6FC6A1" modified="2017-06-07" version="1">MRPEHYEGREIEQTARLLPRSPGDFTREEGGYGRRDSTWPVGPADARAGFSSVVLAGSPRAVPYGTKDQPDVSLTHSGEPIETRGTQAFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2P5</accession>
    <name>A0A1W1I2P5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1108"/>
    <dbReference type="EnsemblBacteria" id="SLM47280">
        <property type="protein sequence ID" value="SLM47280"/>
        <property type="gene ID" value="NSJP_1108"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1108"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="69"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="326" mass="36692" checksum="2B88D2CDBF66C682" modified="2017-06-07" version="1">MEQKTVARKGRTISHRIIHAAILAFAVAGLAHMTSHITWGLDTQDITVEWTEQGKQLAAERVAHWKAKDEMVLVPAGEFVMGSDKKIDRVAYRSELPQRRIYLDAFEIGKYEVTALEYLKFVLVTGRPPQLDWRYDGGNFQETMAHHPIMHVSWYDADAYCRWAGTRLPTEAEWEKAARGEDGRINPWGNQPAGLSRVNFGRTGLSGPVRDRPERLLLYPPIISVDKYENGVSPYGAFQMLGNVSEWVSDWYDKDYYAAAPDRNPKGPETGTQKAFRGGGWMDSTTTMRAAMRNGTDPNTKINWMGFRCAKDAPDASATKVSHIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2R3</accession>
    <name>A0A1W1I2R3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fn3_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1110"/>
    <dbReference type="EnsemblBacteria" id="SLM47282">
        <property type="protein sequence ID" value="SLM47282"/>
        <property type="gene ID" value="NSJP_1110"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1110"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013026318" description="fn3_3 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="fn3_3" evidence="2">
        <location>
            <begin position="218"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="308" mass="34602" checksum="FB60200440E1E3BC" modified="2017-06-07" version="1">MIKYLTVTLIAIILGTPVHAYEEITVADGGTLTGAVTLEGNVPKPKGYNLTTLPDPFYCGRISDGQGWRILQPFQVGPIGEFREVVVYLEGVDKGKPFDDRGLPQIEAKDCLFDPFTTVVRDDQTVTVVNMDPVMHDIQAYETSHLGPRVLFNVPLPMNPQHPHNYKDRSDAALYHRHMAGAPMKQLVNLSKGRRIFVMQCGFHAYMESWGLAATNPYFAKTDEQGRFTMTDVPPGTYKLVVWHPYIRSSVEQTVTIDSKATTEIRIAVPAPTGRLYANEVLDHAYVRYNVTEEAQKEIEPIVEKQDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2X0</accession>
    <name>A0A1W1I2X0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1170"/>
    <dbReference type="EnsemblBacteria" id="SLM47342">
        <property type="protein sequence ID" value="SLM47342"/>
        <property type="gene ID" value="NSJP_1170"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1170"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024623">
        <property type="entry name" value="YtxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12732">
        <property type="entry name" value="YtxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="111" mass="12273" checksum="981BD4243AE6EB49" modified="2017-06-07" version="1">MRNGDYEYYEDDATGWSAFIAGALIGAGVALLFAPQTGSELRGMLRNYASRAKDEAMEKGRAAWDTAVERGREYYEQGQEAVQEAGRTAKEYAQSGKEALREARESSHNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I370</accession>
    <name>A0A1W1I370_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phospholipase D</fullName>
            <ecNumber evidence="5">3.1.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_1157</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.4" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1157"/>
    <dbReference type="EnsemblBacteria" id="SLM47329">
        <property type="protein sequence ID" value="SLM47329"/>
        <property type="gene ID" value="NSJP_1157"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1157"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PTHR18896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="623"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="690"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="4">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="4">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="724" mass="80291" checksum="7F064B69A5404C7C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3C0</accession>
    <name>A0A1W1I3C0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47333">
        <property type="protein sequence ID" value="SLM47333"/>
        <property type="gene ID" value="NSJP_1161"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1161"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="128" mass="14551" checksum="7CEFA1134345D316" modified="2017-06-07" version="1">MQVRSRERPRTPPHDRPRVLFDFPAVEAETDGSRPILRSTRVGQVVSNGDNPSGGWNARRRLRTDVMKKAEETDLLCLAPSLVELAGAKESRGEQWATLTSATKRFERGRVRLRSFPRPVRQRKTTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3C5</accession>
    <name>A0A1W1I3C5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47506">
        <property type="protein sequence ID" value="SLM47506"/>
        <property type="gene ID" value="NSJP_1334"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1334"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="97" mass="10504" checksum="002911A512AD1F23" modified="2017-06-07" version="1">MCSRLRTPGKGVFGLDPGARGGTRTPTVTHEILSLARLPVPPLSHGGESRSSVKPSQQTGEITRSCRYFVPLDICNCQPILLRGNRYVWGPGSKEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3C7</accession>
    <name>A0A1W1I3C7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">mscL</name>
        <name evidence="11" type="ORF">NSJP_1338</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MscL family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1338"/>
    <dbReference type="EnsemblBacteria" id="SLM47510">
        <property type="protein sequence ID" value="SLM47510"/>
        <property type="gene ID" value="NSJP_1338"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1338"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019823">
        <property type="entry name" value="Mechanosensitive_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01264">
        <property type="entry name" value="MECHCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01327">
        <property type="entry name" value="MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM47510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="138" mass="14916" checksum="21ABC70D3CAFA341" modified="2017-06-07" version="1">MLKEFRDFAMKGNVLDMAIGVIIGGAFGKIVSSLVSDILMPPIGLLMGKVDFSSLFLTLSGTPQPSLVAAKAAGTPTLNYGVFLQTVLDFLIVAFVIFLLVKQVNRFKKDAPPAPQAGPTNEEKLLTEIRDAIKNQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3G9</accession>
    <name>A0A1W1I3G9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1375"/>
    <dbReference type="EnsemblBacteria" id="SLM47548">
        <property type="protein sequence ID" value="SLM47548"/>
        <property type="gene ID" value="NSJP_1375"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1375"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="308" mass="34938" checksum="4002D471A5D49947" modified="2017-06-07" version="1">MPARNLRRIRSDVSFTSFFIAELPLDARPAIIPRIMERLPTNSSYIPADRDLEFLQRDDLRAVRVGLELLKPELIQREQGIQSTIVVFGSARVQEPKTAAQLLRSAEDESARFPDDRTRQRRLEIARRQFTLSKYYDIAREFGRLVSSTCQVGNRCDYVIITGGGPGIMEAANRGASDVGAKSIGLNITLPHEQCPNAYITPELSFQFRYFAMRKMHFLIRARALVALPGGFGTLDELFEALTLLQTGKTRHLVVVLIGRDFWDRLIDWPWLVDHGLIAEDDLQLFHYAETAQEAWDLIARHNGVTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3L0</accession>
    <name>A0A1W1I3L0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Glucose-inhibited division protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">gidA</name>
        <name evidence="11" type="synonym">mnmG</name>
        <name evidence="14" type="ORF">NSJP_1410</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1410"/>
    <dbReference type="EnsemblBacteria" id="SLM47582">
        <property type="protein sequence ID" value="SLM47582"/>
        <property type="gene ID" value="NSJP_1410"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1410"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
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        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
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        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
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        <property type="entry name" value="MnmG_N"/>
    </dbReference>
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        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PTHR11806:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GIDA" evidence="12">
        <location>
            <begin position="8"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="GIDA_C" evidence="13">
        <location>
            <begin position="399"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM47582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="638" mass="70419" checksum="7418E584B47F23DF" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3N0</accession>
    <name>A0A1W1I3N0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47561">
        <property type="protein sequence ID" value="SLM47561"/>
        <property type="gene ID" value="NSJP_1389"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1389"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="438" mass="48419" checksum="4D87C7952920B388" modified="2017-06-07" version="1">MNPQAQALADFRSQVTRLLQERDVEWENSRKLVGAGRLPETLRHLIEEVRRVDLPPSICEAILTALNFGHVERVQDLPGPRLKELTGLPPTKAVRALCVWFDLAGASESPAAASSLPATVLEAAIQDEASPFDVLLAADAPSLLDLGAGDLSFASEVADRYAAPVRAQGKTLVLHGVDRLQPQSKLGGPLHPDRLTLDRLRSRPDLSFQFFPGQDMFALERLDRSGKLVPCYTLVTCWAPATPTFAYEPARLGQDAIITELQRTKGLYHQTDYDGEPALEVRHGERSLLFPPWKFDVRGPLALLDLLSRRGQICVLGAVDDQVFWELLSQVLEGEQYRPPLQPFTPDAIKTVFADIYPQLAQLAIGASMSLADCAPLRRQIPRVLPVHAPHAGHYGFQSIRVRRGAWFSGMPVSSTARKFPDMVEEATPWMLTLIPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Q4</accession>
    <name>A0A1W1I3Q4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cysNC</name>
        <name evidence="8" type="ORF">NSJP_1464</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.4" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1464"/>
    <dbReference type="EnsemblBacteria" id="SLM47636">
        <property type="protein sequence ID" value="SLM47636"/>
        <property type="gene ID" value="NSJP_1464"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1464"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
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        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011779">
        <property type="entry name" value="SO4_adenylTrfase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
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    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02034">
        <property type="entry name" value="CysN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="9"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="614" mass="68066" checksum="1516D1CC7EFAF505" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I433</accession>
    <name>A0A1W1I433_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4149 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47762">
        <property type="protein sequence ID" value="SLM47762"/>
        <property type="gene ID" value="NSJP_1590"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1590"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="DUF4149"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4149" evidence="5">
        <location>
            <begin position="25"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="169" mass="19165" checksum="B30F97AC53F3CB49" modified="2017-06-07" version="1">MDALQSIVTDLNTLIPIVNHWFHLLSAVIWIGGLAFLVMAVTPGLQKAVPRQQIKPITDIFYQHYKKVAGILLVVLLFTGGINLHYVNQVLVSQTGAGVQHHPKYLIVFFIKLFLVLCLLTLFLYTVIFKDEGEDDETETYEVIPFQRAALWMGFFIILCAAAMKHLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I441</accession>
    <name>A0A1W1I441_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1467"/>
    <dbReference type="EnsemblBacteria" id="SLM47639">
        <property type="protein sequence ID" value="SLM47639"/>
        <property type="gene ID" value="NSJP_1467"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1467"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="260" mass="28095" checksum="D015F00BF68221A6" modified="2017-06-07" version="1">MGLFFARLVGLARMTGRQVGPVLLCAVLWAALTPVLLSAQHAELHPAAVTAGSHHDGHPVSADGWEGSAAGIAYSERNHHVAGLFVMLMGLAELGYACRWSTLAWIRFVTPAAMLTTGLFLLIWSDHEAWPIGSLTFTQSFFGDESEIVQHKVFGLAAVVVGVIELIRRLGGLRRVWWMAPFPLMAIAGGLMLFAHSHGGHPSGEKIALHHAIMGTMAMTAGSSKLLSGWRKESQASLRWEVVWACLIVVIGAQLLIYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I443</accession>
    <name>A0A1W1I443_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47745">
        <property type="protein sequence ID" value="SLM47745"/>
        <property type="gene ID" value="NSJP_1573"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1573"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMP_b-brl" evidence="1">
        <location>
            <begin position="16"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="233" mass="25231" checksum="948FBDC422185897" modified="2017-06-07" version="1">MRIIRLSSWPIGLATILSCTFALTTSLRAETYVGGQVGMTFPQPLSNGEVTQNGIGGLTIDSDQALKNSIMLGAKLGHYFSKARWIGVETGVSFANPHIKQGPLTLSGPGGTANLGTFSGVYQRMIIWDVATLMFRYPKYRFQPYVGVGPALFFGKLTGPTAPPGQSATNIGLNVEGGGRYYLTRKWALFGEAQYHWARMNYSSNDNNPAADPFAFKANYGALNLSLGVSFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I499</accession>
    <name>A0A1W1I499_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47826">
        <property type="protein sequence ID" value="SLM47826"/>
        <property type="gene ID" value="NSJP_1654"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1654"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="122" mass="13508" checksum="008FBBA0F9DF04FD" modified="2017-06-07" version="1">MDRLSMDRRGASPSHEDRSRQSAGVSRFADRPDRREQNRFIECSGQASRECRQVEGCGGQKKEVKKPSQYQIRELRTLLSDLSGVPGVASPRAPGPSGLRQGMTMREPTEHVVGGTPTSELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4C8</accession>
    <name>A0A1W1I4C8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47868">
        <property type="protein sequence ID" value="SLM47868"/>
        <property type="gene ID" value="NSJP_1696"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1696"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="209" mass="23838" checksum="2D28A05796912A30" modified="2017-06-07" version="1">MNPLDRSGSFTDEETVLLADGEFFRKKQRISAKIRTMLEASHVALRDELTRSRLLAPSDFDATHHQFVKGEHLESCPYQYLDCPKHFQGSDKYTFRTLVWWGHHVVFVWILEGRLVKQYKKNLVDRFHSVAGRHLELSTAPTLWEWKCGEGYTLPLTHDRKATVAAVVAERGFLKIGRYVPLGDARVRQGDLASLAREAFAALSPIVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4G3</accession>
    <name>A0A1W1I4G3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47865">
        <property type="protein sequence ID" value="SLM47865"/>
        <property type="gene ID" value="NSJP_1693"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1693"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="SSF57903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="82" mass="9002" checksum="9C72EAE784F02895" modified="2017-06-07" version="1">MLLPIEPRQCKVCQLGLYRDKTMLRGGWSRCSVCDEFVHYSCLASGKVSFLKARPRICKTCRAAEKAASVPPTAEQPVAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4G4</accession>
    <name>A0A1W1I4G4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47896">
        <property type="protein sequence ID" value="SLM47896"/>
        <property type="gene ID" value="NSJP_1724"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1724"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="384" mass="39699" checksum="419A064693FA946A" modified="2017-06-07" version="1">MMSRIIKRTTAMTRQFLDRSGIEGDTSTMIITAHLSQTSIKRGGQVLLAAVALSLAAFLSRAPELLAAPPMEFCEGRPADQQLRASQGKGSADGPCVPLVEKKDESGKKATSGRAQSRQLKIDNLEAEVASFLQRYNKFLACCKTDLAELEAVEAMGDEVNELLSLAQSGLFSEQIKVRGWTIGELIPPVAQARADLKRLHAQLDEISRTRERLASGHSDTAAKDSRKIHELEDAIQRDFQPRPVPAGPKTGTGIGASPSVGTGIGMTPKTGSAIGKGGTTGSDFGVTPKTGVDIGATGPVGFEIGTTGRAGAAVGESTLNTNQSAVGSSLRPSSVESNLPDSTVGSTLGGSTIGSGLSDSTIGSTLGGSSVGSSLQNRGTSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4G7</accession>
    <name>A0A1W1I4G7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lipid II flippase FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ftsW</name>
        <name evidence="8" type="ORF">NSJP_1732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1732"/>
    <dbReference type="EnsemblBacteria" id="SLM47904">
        <property type="protein sequence ID" value="SLM47904"/>
        <property type="gene ID" value="NSJP_1732"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1732"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013437">
        <property type="entry name" value="FtsW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02614">
        <property type="entry name" value="ftsW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="397" mass="42096" checksum="E53B2D7431ABA70E" modified="2017-06-07" version="1">MASRSAGTLSLPWQAAGQRSAKQRVPMDHTLLVVTLTLALVGLVMVFSASAIMAANRFQDPEFFLKRQVAWLGMGVLMMHAMSRVDYLLWKKLAIPILICMVLLLIVVLIPGVGVVTKGARRWLRAGPISMQPAEMVKLTAVIYLAYYLTKKKDKIALFGSGLLPVLIVMGILSGLVLLQPDLGTVVVMGLVAVGLLFLGGAKVSHLASLALCAVPVMAALVLGSSYRRQRLMTFLAPWKDASDAGFQITQSFLAFGSGGPFGVGLGEGKQKLFFLPEAHTDFVLALVGEELGLAGTATVILLFAVFVWRGFVIAARARAPFGRFLGLGITLLIGIQALVNAAVATGMLPTKGLTLPFVSYGGSSLIVNFVGVGILLSISRDRHAGGSKGGRGELDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4K4</accession>
    <name>A0A1W1I4K4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsR</name>
        <name evidence="7" type="ORF">NSJP_1764</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1764"/>
    <dbReference type="EnsemblBacteria" id="SLM47936">
        <property type="protein sequence ID" value="SLM47936"/>
        <property type="gene ID" value="NSJP_1764"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1764"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="88" mass="9969" checksum="6932B3A753E11BA3" modified="2017-06-07" version="1">MERERGGSGGGRGDGGGRFFQRRRPCRFCVEKGPIDFKDVGLLRNFLTERGRIVPRRISGNCLGHQRELTTAVKRARHIALISFAEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4K5</accession>
    <name>A0A1W1I4K5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NSJP_1758</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1758"/>
    <dbReference type="EnsemblBacteria" id="SLM47930">
        <property type="protein sequence ID" value="SLM47930"/>
        <property type="gene ID" value="NSJP_1758"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1758"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03914">
        <property type="entry name" value="UDG_fam_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="43"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="214" mass="23465" checksum="FAF14D4577DFBACD" modified="2017-06-07" version="1">MKLHPFQSAASFIPPRLTPPALRRAAACCTGCDLYRTATQTVFGEGPRHPSIVFVGEQPGDQEDRMGRPFVGPAGALLNRALAEAGIARDKVYVTNAVKHFKWEPQGKKRKHKRPSAAEVAACRPWLQAEVSVLKPHALVCLGVTAAQSVFAKTVRLSELRGRPWDTALATHVFVTIHPSAILRYPDAAARSEAFGRLVEDLRRIGRFVRNQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4N7</accession>
    <name>A0A1W1I4N7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-oxoglutarate:ferredoxin oxidoredutase gamma subunit</fullName>
            <ecNumber evidence="3">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">forC</name>
        <name evidence="3" type="ORF">NSJP_1788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.3" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1788"/>
    <dbReference type="EnsemblBacteria" id="SLM47960">
        <property type="protein sequence ID" value="SLM47960"/>
        <property type="gene ID" value="NSJP_1788"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1788"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011894">
        <property type="entry name" value="PorC_KorC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02175">
        <property type="entry name" value="PorC_KorC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="13"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="238" mass="25867" checksum="42C68CD943609E3F" modified="2017-06-07" version="1">MAKRFNIRMAGVGGQGVVTGSHILSTAVINAGGESTIVPFYGSEKRMAPVESYVRVSDEAIYEIGEITFPHIIIIFHPQVITHGKSYTMPFYFGLKEDGVALINNDGPMRLHKDQARELEERRAKLYYFPATKISLEVAGMDLATNMALMGCIGAITGLTNMAGLDQAVKDRFLGKGFVVSGGTAALDSVVERKFKKKQELIEKNVAVMRAGWNYAVDHGWAAADVKRAEEPVAAANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4R1</accession>
    <name>A0A1W1I4R1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_1793</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1793"/>
    <dbReference type="EnsemblBacteria" id="SLM47965">
        <property type="protein sequence ID" value="SLM47965"/>
        <property type="gene ID" value="NSJP_1793"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1793"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="402" mass="44186" checksum="4D8F386A24443B07" modified="2017-06-07" version="1">MHGSKARPPAAPSPLVLKVMNQVVQAGIGACPVEIPSAVADLSHLFTKGRGSLGACYLDDSAYAAAYLSYFMPVNLSKVQLLLDELPPDTMVKEAGTPVRFLDLGAGPGTGSLALLDWMHRRYPGSAARLSTLAVDSSGEALRQAGDLWKRYCHEAGISGAELIGCQADVERSGKEAWRRKAERQAPFDLILLANCLNELYLDAADPVAARAALLAELLQWLAPHGTLILLEPALRDTARALHQVRDRLLGEKRCTVYSPCLHQQDCPALIHPDDWCHEERTWDAPRSIRDIDEAVGFIKDALKFSYLLLRTDGRTIAQRSPHTFRIVSELRELKGDIRAWVCNELGRTEIGRLDRAESETNCAWSECRRGTIVQIEGLKRKDGATLARIPADGTVEIVRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4S0</accession>
    <name>A0A1W1I4S0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_1803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1803"/>
    <dbReference type="EnsemblBacteria" id="SLM47975">
        <property type="protein sequence ID" value="SLM47975"/>
        <property type="gene ID" value="NSJP_1803"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1803"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042204">
        <property type="entry name" value="2Fe-2S-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="236" mass="26123" checksum="40A27CA53B37E8A5" modified="2017-06-07" version="1">MAQDDTNVIDQPEVLKPRMVTIEISGKKYEVPEGITVIKALWYTGQEVVRGAGCLGGFCGACATYYRTKDDPKVRTCLACQMAVQDGMSFTIMPPFPARKAIYDIQTLKDPKQDLFNLYPEAPLCRNCNACTEACPQKIDVREGVWKAVFGDFKSVSEMFMDCVMCGMCTPVCIADIAPNLVALYVSRAQGAHFAEKPAGLQARINEIQAGRFNDEWKKILAMNDKELGDHCATVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Z4</accession>
    <name>A0A1W1I4Z4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48055">
        <property type="protein sequence ID" value="SLM48055"/>
        <property type="gene ID" value="NSJP_1883"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1883"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="65" mass="7465" checksum="0712AE7E5AEC39CB" modified="2017-06-07" version="1">MRAIFLIVRPLQIIEAAPVSGNITTPANRLQVIGNQIQFLEEVQYWISVFGLVFPEEVCLRRIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Z6</accession>
    <name>A0A1W1I4Z6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative low-affinity inorganic phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pit</name>
        <name evidence="7" type="ORF">NSJP_1829</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48001">
        <property type="protein sequence ID" value="SLM48001"/>
        <property type="gene ID" value="NSJP_1829"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1829"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="331" mass="34425" checksum="65EE41DFCEE76ECE" modified="2017-06-07" version="1">MMLELNGMLLLVVLLALLFDFSNGWHDSANAIATVVSTRVVSPLVAVIMAGILNIAGAFMSTAVAKMVGSGIVDPSTVTQQMVASALAGAILWNLFTLLLGLPTSSSHALIGGMVGAAVTHGGWDTVKLSGLRSVLEAMVLSPFFGFAIGLSLMVLISWMFFRVPRGIATKIFKRLQLLSACFMAFSHGANDAQKAMGIITLALLSAGQIQSHDVPGWVIGACAVAMGLGTAAGGWRIVRTLGMGIVKLEPVHGFAAETGAAAVLMVTAHIGLPVSTTHTITSSVMGVGAIKRLSAVRWGVTRRILYAWLFTLPGAAILASVIYLVGTRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Z7</accession>
    <name>A0A1W1I4Z7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48088">
        <property type="protein sequence ID" value="SLM48088"/>
        <property type="gene ID" value="NSJP_1916"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1916"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="69" mass="7938" checksum="21B1569011FFAF27" modified="2017-06-07" version="1">MSFHRKAGKPLTSPSLSSFYLLNFVICRSPFHVGWSAPLFRYGVRVLTELRLRLLIGASFQALRTPENW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I516</accession>
    <name>A0A1W1I516_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 7" type="primary">sucD</name>
        <name evidence="7" type="ORF">NSJP_1807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1807"/>
    <dbReference type="EnsemblBacteria" id="SLM47979">
        <property type="protein sequence ID" value="SLM47979"/>
        <property type="gene ID" value="NSJP_1807"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1807"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="290" mass="30052" checksum="3754476F8B998830" modified="2017-06-07" version="1">MSILVNKATRVVVQGITGKEGSFHATQCKAYGTQIVAGVTPGKAGQEVEGIPVFNTVSDAVKKTECDTSLIFVPPPFCADAILEAADAGVKLIICITEGIPVNDMVKVKRALHGRDVRLIGPNCPGVITVDEAKIGIMPGFIHKKGIVGVVSRSGTLTYEAVHQLSTLGLGETTCVGIGGDPVNGTGFVDVLPLFEKDPETQAIVMIGEIGGDAEEKAAEFIRKHVKKPVVSFIAGITAPPGRRMGHAGAIISGGKGTATEKMKALEQAGVKVVKNPAEIGNAVKKALGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I557</accession>
    <name>A0A1W1I557_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48019">
        <property type="protein sequence ID" value="SLM48019"/>
        <property type="gene ID" value="NSJP_1847"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1847"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012777288" evidence="2">
        <location>
            <begin position="26"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="172" mass="18935" checksum="681DE8B0389A4188" modified="2017-06-07" version="1">MRSKPLGWSRTLAAVVVMFPGVVLATHEADHRFTVEGFVCGAEGQGVPNIDVMVKDTKVSYGQVVKTDSEGYYKATFHLHNDNLGDPLLIEAKGEQREERVQFDPKDLESERKVQVHFGSGCIQDVTRPPMWVYAGLGAGALALGGIVGAKLIRSRKKQGQKRGKSQDKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I558</accession>
    <name>A0A1W1I558_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-oxoglutarate:ferredoxin oxidoredutase alpha subunit</fullName>
            <ecNumber evidence="4">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">forA</name>
        <name evidence="4" type="ORF">NSJP_1791</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.3" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1791"/>
    <dbReference type="EnsemblBacteria" id="SLM47963">
        <property type="protein sequence ID" value="SLM47963"/>
        <property type="gene ID" value="NSJP_1791"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1791"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="2">
        <location>
            <begin position="67"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="3">
        <location>
            <begin position="311"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="447" mass="48637" checksum="209DC98F36B2BA1F" modified="2017-06-07" version="1">MSEALEAQQKTNPQGDPITSVAAPKADGKKDPHAEAKRQKVVTPEYMFHEAPRTKEFITGSEAAKEAIRRSNVDLAIAYPITPQSETMQLVGVLYGEGYVKEYYRGEEEVGVMAAIAGGSRAGVRCYTATAGPGTLRGLEGIASWPGHRLPVVAMFTCRVVNAPLAIQPDNIEVSYLLNCGMIVFHAENQQDMFDFTMAGFTISEKNDVTLPVGVCCDGFFVTHARGYVRMQDRGIKLPPREAWRGAVPVLDAENPPARLSRDAPVQKSNFMAYNIHAVWQQEVWAAVERSRKYINQYIGGLLSAENVEGADAIIIASGSAAAQSREAVRICKDKGLNVGLIKIRSLRPFPTKELRELCGKAKLIVVPEFNYVGWLAKEIATAIYGFSKAKIIGGPRVYGGQSMPVELIVDEVESGLTGKKSTNVAMSQIMGGAVNPDDVAHFMRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I585</accession>
    <name>A0A1W1I585_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48162">
        <property type="protein sequence ID" value="SLM48162"/>
        <property type="gene ID" value="NSJP_1990"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1990"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="106" mass="11843" checksum="7F71C934F7BB8A4D" modified="2017-06-07" version="1">MAFSLWGFLLEHLKGRIMESEDNVIAELLKELTGLINQYPKAIEHRAAMIQATGKDPELVEKLVKAADTMRDSGNLYLTWAKHYAALAEGNSDASSDEDETEDFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5L5</accession>
    <name>A0A1W1I5L5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpmA</name>
        <name evidence="7" type="ORF">NSJP_2108</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2108"/>
    <dbReference type="EnsemblBacteria" id="SLM48280">
        <property type="protein sequence ID" value="SLM48280"/>
        <property type="gene ID" value="NSJP_2108"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2108"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="87" mass="9220" checksum="480D34642C9CCE6F" modified="2017-06-07" version="1">MATNKGGGSSRNGRDSNPQYLGVKAYGGETVKAGAIIVRQRGTKFFPGFNVGLGKDHTLFARITGTVKFEGGRARQKVSVYPTPTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Q2</accession>
    <name>A0A1W1I5Q2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48342">
        <property type="protein sequence ID" value="SLM48342"/>
        <property type="gene ID" value="NSJP_2170"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2170"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="75" mass="7657" checksum="C9D6F3347CDE6A85" modified="2017-06-07" version="1">MPIFQDRIALPVFWTGAGALDGWFDEGVLVWGFGVEPPDEELGGGLEDVLGAVWGVDLGAVGAVLDGVTTGGRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I626</accession>
    <name>A0A1W1I626_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7-cyano-7-deazaguanine synthase</fullName>
            <ecNumber evidence="1">6.3.4.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-carbaguanine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PreQ(0) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Queuosine biosynthesis protein QueC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">queC</name>
        <name evidence="2" type="ORF">NSJP_2278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-carboxy-7-deazaguanine + ATP + NH4(+) = 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27982"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the QueC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.20" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2278"/>
    <dbReference type="EnsemblBacteria" id="SLM48450">
        <property type="protein sequence ID" value="SLM48450"/>
        <property type="gene ID" value="NSJP_2278"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2278"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01995">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01633">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914">
        <property type="entry name" value="PTHR42914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006293">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00364">
        <property type="entry name" value="TIGR00364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="232" mass="24731" checksum="7DC84C2F3AE3F181" modified="2017-06-07" version="1">MSGVNGSRAVVLASGGLDSAVTAAIARRDGHELYFLTFDYGQRHAVEVRQARRLAEAMAVTHHLVCSVDLRAIGGSALTGDQGVPKDFDRPGRASEIPVTYVPGRNLIFLSLASAYAETIGAESVYFGANVLDYSGYPDCRPQFIRAFEKAVKEGTKAGVEGRALRVQAPLLALSKADIIREGVALGVPLALTHSCYDPVGDLACGQCDSCRIRRDGFRTAGVVDPTRYAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I670</accession>
    <name>A0A1W1I670_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">rpsG</name>
        <name evidence="9" type="ORF">NSJP_2334</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2334"/>
    <dbReference type="EnsemblBacteria" id="SLM48506">
        <property type="protein sequence ID" value="SLM48506"/>
        <property type="gene ID" value="NSJP_2334"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2334"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="8">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="156" mass="17706" checksum="96483C9487206EAF" modified="2017-06-07" version="1">MPRSRFLGQREPLPDVRYRDKIVGKFLNILMENGKKSTAERICYGAFDAIQEKTGGDPLKIFKAAIDNVKPIVEVKSRRVGGASYQVPVEIRPARRMSLALRWLSEYARTRGGKSMREKLAAELLDASNNTGAAVKKREDVHRMAEANKAFAHYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I692</accession>
    <name>A0A1W1I692_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rplN</name>
        <name evidence="6" type="ORF">NSJP_2348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2348"/>
    <dbReference type="EnsemblBacteria" id="SLM48520">
        <property type="protein sequence ID" value="SLM48520"/>
        <property type="gene ID" value="NSJP_2348"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2348"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="122" mass="13617" checksum="333C7DEF973A2920" modified="2017-06-07" version="1">MIQNYTYMDVADNSGAKQAMCFHVLGGSKRRYASLGDIIVVAVKEAIPQATVKKGDVSRAVIVRTTKEVRREDGSYIKFDRNACVLINKDGEPVGTRIFGPVARELRWKKFMKIISLAPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6D3</accession>
    <name>A0A1W1I6D3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Urease subunit beta</fullName>
            <ecNumber evidence="2">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Urea amidohydrolase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">ureB</name>
        <name evidence="4" type="ORF">NSJP_2395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the urease beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2395"/>
    <dbReference type="EnsemblBacteria" id="SLM48567">
        <property type="protein sequence ID" value="SLM48567"/>
        <property type="gene ID" value="NSJP_2395"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2395"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01954">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="SSF51278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="143" mass="15710" checksum="230A8724CB6C49FC" modified="2017-06-07" version="1">MATQKPPASAKTPVGGYVLSDKPIEINAGRPTVKIKVRNTGDRPIQVGSHFHFFEVNRALEFDRKAAFGQRLDIPASTGLRFEPGDEKEVTLVPFGGKQRIHGFNNLVDGWTGAGPTPGYRPNLDKGLERANERGFKSKNKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6E8</accession>
    <name>A0A1W1I6E8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV pilus biogenesis protein PilM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pilM</name>
        <name evidence="2" type="ORF">NSJP_2373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2373"/>
    <dbReference type="EnsemblBacteria" id="SLM48545">
        <property type="protein sequence ID" value="SLM48545"/>
        <property type="gene ID" value="NSJP_2373"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2373"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005883">
        <property type="entry name" value="PilM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11104">
        <property type="entry name" value="PilM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019169">
        <property type="entry name" value="PilM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01175">
        <property type="entry name" value="pilM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="1">
        <location>
            <begin position="23"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="367" mass="39520" checksum="1C07BAC635036928" modified="2017-06-07" version="1">MLNSLKSLVETDIFSMLTPKRQLVGLDIGSSGIKLVQLKEHRGRYLLQKFGVKPLEPEVIVDGTVMDEGRVVSAIKELFEELKVKVKQVAVSISGHAVIMKKISLPPMPDDELEGQVRLAAEQYIPFDINEVNIDFHVLPPSEGDAEEGEMSVILVAAKKDKINELTELVKGAGLFPMVMDVDAFAIENMHAISYPVSQEDTTALVNIGASVMNINIVRGGVSVFTRDIPIGGNRYTEAMQRELGLSYEDAEETKKGGRSAGSSQAVTGVIDSVNAEVASEIARTVDYFKSTMSDAEVQHVVLCGGGAQVAGLEQQLRDRMNAMVEIANPFGEIDTSGCDMDQATLAEMAPIAAVGVGLALRSVGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6F7</accession>
    <name>A0A1W1I6F7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48592">
        <property type="protein sequence ID" value="SLM48592"/>
        <property type="gene ID" value="NSJP_2420"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2420"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013117004" evidence="2">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="109" mass="11414" checksum="046E784677C9C66D" modified="2017-06-07" version="1">MKPFVMLLAITLFVCLTSVAASANPATLPKHPGYPMDKAIDPVAGKPLANDPGRGNATGNAALMESAAFDDVHAMQSLPSTPAEQEIREKLTAPVPQNAEDAGMTDQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6G5</accession>
    <name>A0A1W1I6G5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative (Glutamate-ammonia-ligase) adenylyltransferase, subunit A (Modular protein)</fullName>
            <ecNumber evidence="6">2.7.7.42</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_2430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.42" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2430"/>
    <dbReference type="EnsemblBacteria" id="SLM48602">
        <property type="protein sequence ID" value="SLM48602"/>
        <property type="gene ID" value="NSJP_2430"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2430"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008882">
        <property type="term" value="F:[glutamate-ammonia-ligase] adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023057">
        <property type="entry name" value="GlnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005190">
        <property type="entry name" value="GlnE_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30621">
        <property type="entry name" value="PTHR30621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03710">
        <property type="entry name" value="GlnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GlnE" evidence="4">
        <location>
            <begin position="340"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="GlnD_UR_UTase" evidence="5">
        <location>
            <begin position="619"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="755" mass="85164" checksum="F0599EE1FA41426C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Q9</accession>
    <name>A0A1W1I6Q9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAVED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2530"/>
    <dbReference type="EnsemblBacteria" id="SLM48697">
        <property type="protein sequence ID" value="SLM48697"/>
        <property type="gene ID" value="NSJP_2530"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2530"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040836">
        <property type="entry name" value="SAVED"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18145">
        <property type="entry name" value="SAVED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAVED" evidence="1">
        <location>
            <begin position="204"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="400" mass="45582" checksum="5CEAFFA388B4CEB6" modified="2017-06-07" version="1">MPQMKMKKGHSGRRGIRVLYEVTRHIGRCEERELWARAAGRCQFKGCNRILYKSPVTQECVNVSEKAHIYSFSARGPRGQGPLSQKKRLLNNIGNLMLVCHDCHRKIDKELDGGRYTVELLTKWKHHHEKRIAIVTGVAPTKKSTVVLYGANIGDELSPLQAQEAHLAMFPHSCPSEELPLRLNMKWEGKDNDPQYWMTEEQNLRRGFERLIYPRISEGDNFSIFGLAPIPLLIRLGTLMTDKIPAQVYQLHREPDQTWLWSKKSHDTNYLLKSPASFEDPPALIISLSSHIAPQRVTSILGEHVAIWELTIEEPHNDFLQCRMQLSGFREAARRMIAKIAKQHGQNTPLAIFPAMPVATAIELGRVRMPKADMPWIIYDHNNKTGAFAMALKISGGVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6R8</accession>
    <name>A0A1W1I6R8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2540"/>
    <dbReference type="EnsemblBacteria" id="SLM48707">
        <property type="protein sequence ID" value="SLM48707"/>
        <property type="gene ID" value="NSJP_2540"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2540"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018655">
        <property type="entry name" value="DUF2086"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09859">
        <property type="entry name" value="Oxygenase-NA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="235" mass="26660" checksum="BF1A3114EBB04115" modified="2017-06-07" version="1">MTIEDRVARLDWKSIEASLWQRGYANVDSLLTSEECDALVALYGKDQLFRSRIDMKRFRFGEGEYKYFTYPLPPLVQTLRETIYPQLAVIANSWAKALAQPESFPLSHDKLLAFCRRNGQAKPTPLLLRYGAGDYNCLHQDLYGTVAFPLQLTAFLSRPSRDFSGGEFLLVEQRPRAQSRGEVLAPKQGDVVIFATRYRPVQGSRGYYRGNMRHGVSTVRSGSRVTLGVIFHDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6S2</accession>
    <name>A0A1W1I6S2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48694">
        <property type="protein sequence ID" value="SLM48694"/>
        <property type="gene ID" value="NSJP_2527"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2527"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="196" mass="21206" checksum="DBEDDCCC86A73ADA" modified="2017-06-07" version="1">MLTASEYGVFAPLVAIISTIMAAGAAVILLWAGPLEKWRPADADLPGMAKRIIFLACSVVMVLLALESAPQNLEWMKETAWWLLGVWVVLGIVYSALRYGLYHSKVNPNGKGRKPILGGLWMRAAAKTSMKQNKITEVDDLLDGAPGPQAIWSGPSRFLARVLILGMFIVFVVSATTSLMAVGLITYVKTTGKALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I712</accession>
    <name>A0A1W1I712_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ispU</name>
        <name evidence="3" type="ORF">NSJP_2623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2623"/>
    <dbReference type="EnsemblBacteria" id="SLM48790">
        <property type="protein sequence ID" value="SLM48790"/>
        <property type="gene ID" value="NSJP_2623"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2623"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="36"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="261" mass="29790" checksum="10E2BAC4C0292D36" modified="2017-06-07" version="1">MNTGLSAGSDQLSDADLAAKLDPDLLPKHLAIIMDGNGRWAEARNLPRIAGHREGIKSVREMITSCLELGIPALTIFAFSQENWNRPTQEINALMGLLEYYLSTERNKLIEQGVRFRTIGRAELLPASALQWVRAAEHETAHLNKLHLTVALSYGGRAEMVDAVRQIAREARDGKIQPDEIDEPLVHQFLYTHDLPDPDLLIRTSGETRISNFLLWQLAYTELYFTPTLWPDFRRRELLLALLEFQRRERRFGRVFSSLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I734</accession>
    <name>A0A1W1I734_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2665"/>
    <dbReference type="EnsemblBacteria" id="SLM48832">
        <property type="protein sequence ID" value="SLM48832"/>
        <property type="gene ID" value="NSJP_2665"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2665"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007463">
        <property type="entry name" value="DUF507"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04368">
        <property type="entry name" value="DUF507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="93" mass="10926" checksum="A5DFDACF72CAED93" modified="2017-06-07" version="1">MRLSKERIRHMAEALAVRLETEGDVTLNAPRKSFAQALETVITDELSIEDRLNTEVRQMLKAHEQEIERGRVDYQKMFMMLKQKLARERGLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I740</accession>
    <name>A0A1W1I740_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48795">
        <property type="protein sequence ID" value="SLM48795"/>
        <property type="gene ID" value="NSJP_2628"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2628"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="224" mass="25944" checksum="700B9C622B1C25D2" modified="2017-06-07" version="1">MKFWACFRHKSPMLTLVQFPWSPFCITVRHILEHNGIPFRMRNIAYHERDLIITATKGRGHTVPCVMDAKEAVCDVTDFGQEVARYIDGRYKLNLFPEQFEGLQLILSRYIENDLEMVGFKVNDSHLIPTRPHGRTRHAHPSQRAEIRKGLCPGMDQPSRVSQRQILRAADPARPYPETIIISAQRSSAFRRLRPLRRAEQLFVQRKNEIPQSKEPPALVSGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7B4</accession>
    <name>A0A1W1I7B4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="7">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_2592</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2592"/>
    <dbReference type="EnsemblBacteria" id="SLM48759">
        <property type="protein sequence ID" value="SLM48759"/>
        <property type="gene ID" value="NSJP_2592"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2592"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="6">
        <location>
            <begin position="94"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="317"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="663" mass="73047" checksum="57824AA7B7989065" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7E3</accession>
    <name>A0A1W1I7E3_9BACT</name>
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        <submittedName>
            <fullName evidence="3">Putative Permease of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2747"/>
    <dbReference type="EnsemblBacteria" id="SLM48914">
        <property type="protein sequence ID" value="SLM48914"/>
        <property type="gene ID" value="NSJP_2747"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2747"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="70"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="163" mass="18084" checksum="32A7169E6D46F203" modified="2017-06-07" version="1">MGYVDDNLLPGERVHYRARLHWKLFVGPVLLTILGLAFVGLAINQGFDPYWSLLILVIPAGTVLSAYLTWRCSEFAVSDKRVLIKTGIVGRHTLETLLTKVENIGVEQTLWGRLFNFGTIYVTGTGSTRETFAGIHAPLEFRKAIEAAAVAFEERRPGGRPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7F5</accession>
    <name>A0A1W1I7F5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48915">
        <property type="protein sequence ID" value="SLM48915"/>
        <property type="gene ID" value="NSJP_2748"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2748"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012506524" evidence="3">
        <location>
            <begin position="31"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="435" mass="46352" checksum="8516C1BC5FDFA103" modified="2017-06-07" version="1">MLTWYGRLGFQFWLCPVIAALVALESPVSAATTIYTYTDDSGTQNFTTESSSIPEKYQSRVTQLDLGSVSNPPVVPAAQRPPSENVRVVTASGEYRMGDHDTKSDATRLAVEAAKRQALEQVATYLESITEVTGMELTRDEIRTYTAGIVMVVDQKISTALDGDTIVIRADLTAQVDPDEVAQAIMALHENESAKTELLALRSETDQLRQQLDAANQILAAAVSPEEVQQVSRQREDLLNQIQANALVSQAWTDWVYVTPGVYPSPSIGLQQVRGLLVQAQRLQPHNRHLPTVQQVIAAQSAGLPPAPPAATFSAPSSGSLLVPPAPTPAPTSPSFPSAAAGTNAMRPPIPTQALPPASSNAVTNAQMHRGPSLAPLPPLPSPLPPTLQQIHPPHMAQPNPPILRAPYTVPHQHHQGGRAFGRAGGGGGHSGGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7G3</accession>
    <name>A0A1W1I7G3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2767"/>
    <dbReference type="EnsemblBacteria" id="SLM48934">
        <property type="protein sequence ID" value="SLM48934"/>
        <property type="gene ID" value="NSJP_2767"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2767"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010297">
        <property type="entry name" value="DUF900_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05990">
        <property type="entry name" value="DUF900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013229785" evidence="1">
        <location>
            <begin position="32"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="433" mass="48537" checksum="E0EED8D9FF8189B5" modified="2017-06-07" version="1">MMNRFRAGGRFHNLLAAVPLTAAALVAGCTAADQHMMPTPMLYKDPRIELSHLVPLALRSPELPVFYATNRKPVSAGSAGHYSATESETVTLGVADVKLGKPGWDWNQLVASDLTDRIDKPRPARVHQVREFGSLRGDGELTESERAFVAAIDEHLALTRNQDLTLYVHGYRVTFDEVSVLMASFARYLGHSATISFQWPTNLYFWNYLTDCPRALKYIPHIERLIELATHTRAVRLNLVAYSCGSPMLAEALVRLRGRYPDEGQNELQRRFRIGNVIFAASDLDVKTFARDGFPSIRQLATQIIVYVSRNDEALAFSAFLARTSRVGRPDVKELTREELDAFAADSTFEVIDVTDVNGAHELHGMKGHGYWFANDWVSSDVTISMRYPVPAQHRCLKPGSGHNVWLLPDDYQDCLVKRLLETYPVLRPASPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7K1</accession>
    <name>A0A1W1I7K1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fis family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_2819</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2819"/>
    <dbReference type="EnsemblBacteria" id="SLM48986">
        <property type="protein sequence ID" value="SLM48986"/>
        <property type="gene ID" value="NSJP_2819"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2819"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="30"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="358" mass="39394" checksum="B32E86F54327A6F8" modified="2017-06-07" version="1">MSTMSVHEPTHIVAASDPHKLALSIRASCLVFEDAASQALLERVRLIAPSDATVLIIGETGTGKELIARHIHDLSERRSGPFIAVNCAAISESLMESELFGHERGAFTGAIAPKTGWFEASQGGSLFLDEIGDLPLPLQAKLLRVVQEREVVRVGSRQSVPVDVRLIAATNVKLDEAVAAGRFREDLYYRLNVATVSLPPLRERPGDILPLVRHFLSQYGTKLGYSTVDLAPDALRAVLAYPWPGNIRELENTIHHALLICSGTTVGADDLRLPTPRSHATSPTAAPGALSLEAALQDLFERDTHQLYRLIDETVIRTAYDYCEKNQLRTARLLGISRNIVRDRLFRYGLLTSQKDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7K2</accession>
    <name>A0A1W1I7K2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine O-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">srpH</name>
        <name evidence="6" type="ORF">NSJP_2813</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2813"/>
    <dbReference type="EnsemblBacteria" id="SLM48980">
        <property type="protein sequence ID" value="SLM48980"/>
        <property type="gene ID" value="NSJP_2813"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2813"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="319" mass="34830" checksum="6B1FFB4E01369DB9" modified="2017-06-07" version="1">MRQQEAETASWNLDQIVTELRASRELTHNIRHQGQIRELPSRKALLGIVEGLCAALFPTHYGRADLNEANIDYFVGHTLNQTLPLLQDQVRKGLLFASDTDDSDERSLAQRASRITSDFASRLPIIRGLLYTDLQAAYQGDPAATSTSEILLCYPGMTAVIYYRIAHALHELGSTLVARLTSDIAHSSTGIDIHPAADIGSHFFIDHGTGVVIGETTVIGQRVRLYQAVTLGAKRFTEGENGVLVKGEPRHPIVEDDVVIYAGATILGRITIGRGSVIGGNVWLTQSVPAGSHVMQAQMRTSTTIQPKSLSERIGQWSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7L3</accession>
    <name>A0A1W1I7L3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49012">
        <property type="protein sequence ID" value="SLM49012"/>
        <property type="gene ID" value="NSJP_2845"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2845"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="47" mass="5694" checksum="BF8E27DD4D0E647C" modified="2017-06-07" version="1">MLEHTRELRGKRMRRLNYRMALLTVSLIRTFRVRTFRNRVVVCAAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I845</accession>
    <name>A0A1W1I845_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49029">
        <property type="protein sequence ID" value="SLM49029"/>
        <property type="gene ID" value="NSJP_2862"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2862"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="313" mass="34501" checksum="5FBF23B09785E061" modified="2017-06-07" version="1">MVLLGHHPSIAETGISDPVSETETVEEQSVESEDEPGSEQGPVDPNAPDGTKRRTRLFKRIAPKNLTPQEEEEAERLRKLAARYGTDPTAIVGRLQLSSQYLDLPQSTHATATVARVDLPFRGNYLLRFDLPFLKTVDPSRPGATNLHGMSDLAITAGWRAYNTPEYAVLIGAVTTMPTAAEPGLGFGKYTVGPALATARFLPRWDSFLIGLVQYQTSVGGDPSRQNVSFLNTTAQLNSFWGRHWWTILNAVLQVNFEQNAKSSMTVEFEGGRNLVGTLGAYVRPGVGIWGRDLPGAYIWNIEMGVRYMFKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8J5</accession>
    <name>A0A1W1I8J5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zot domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49326">
        <property type="protein sequence ID" value="SLM49326"/>
        <property type="gene ID" value="NSJP_3159"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3159"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008900">
        <property type="entry name" value="Zot_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05707">
        <property type="entry name" value="Zot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zot" evidence="2">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="383" mass="41831" checksum="4D7D1DE533910BEA" modified="2017-06-07" version="1">MIELLEGVPGAGKSYHAVAEYLLPWVRKGRRIYVYVDGFYLDRLAKFEGRPLEELENQITVWSSGAEVLDQLTKVDPGSAVFIDECQTVFRAQQKLNGEILRWLETHRHYGIDVLLICQDYRQVTSGVTRVVEMTTKFRRLDRFGFKNRYQAFVRGNPEEIEVIRGFTGTYEPTVYAYYGSYATPTKEVRHVRSILRSPSIILGALGLCSALGWFVFGGGTFGKGTALPPPPVSASLAAVHVTSQLHEPSAPLPVVRPIRIQGGMSDPRHGRDEWLWITDDGRLLTLDEIAAESGGTVQAVTSRGVKVLKGSGVLWGGTASTPSVSAGSRPEPVLAPSRLPTRTDLLVAPTSARVGQSVGESPDLVTSDPTHEAMGQGTEGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8M2</accession>
    <name>A0A1W1I8M2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Thiamine biosynthesis protein ThiS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3104"/>
    <dbReference type="EnsemblBacteria" id="SLM49271">
        <property type="protein sequence ID" value="SLM49271"/>
        <property type="gene ID" value="NSJP_3104"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3104"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34472">
        <property type="entry name" value="PTHR34472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="66" mass="7293" checksum="3A438BAA7A82E7EB" modified="2017-06-07" version="1">MQVKINGKVEEVSAGTVMDLLQAKKIEPQMVAVEVNDTMVERTQLATTTLKEGDRLEFLFYMGGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Q5</accession>
    <name>A0A1W1I8Q5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49428">
        <property type="protein sequence ID" value="SLM49428"/>
        <property type="gene ID" value="NSJP_3260"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3260"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="131" mass="14507" checksum="EE40EBB76A42E0DA" modified="2017-06-07" version="1">MRKVLLECNIAIYCHKNIVLSLRPPQEIAVLNAGPASLRDRDNLMAFNLIGQSTIDTLVEEKFHEATGNMRVFASSRKAITCSRVTVGNPSRKSSMVCPPSKYSMRVWTGTRVSRNTGVPPRISGLEVMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Z2</accession>
    <name>A0A1W1I8Z2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable DNA ligase</fullName>
            <ecNumber evidence="12">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Polydeoxyribonucleotide synthase [ATP]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 16" type="primary">lig</name>
        <name evidence="16" type="ORF">NSJP_3320</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="12 14">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="12"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3320"/>
    <dbReference type="EnsemblBacteria" id="SLM49487">
        <property type="protein sequence ID" value="SLM49487"/>
        <property type="gene ID" value="NSJP_3320"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3320"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00407">
        <property type="entry name" value="DNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022865">
        <property type="entry name" value="DNA_ligae_ATP-dep_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 12 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 12 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 12 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 12 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="15">
        <location>
            <begin position="290"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="12">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SLM49487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="514" mass="57304" checksum="57070EF2AC851B9A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I915</accession>
    <name>A0A1W1I915_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49517">
        <property type="protein sequence ID" value="SLM49517"/>
        <property type="gene ID" value="NSJP_3350"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3350"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="110" mass="11996" checksum="C2079301B3AF458C" modified="2017-06-07" version="1">MSWYHKTCGEANSRASNSNDLTSPALKIFCDALSDVVRPRGSETGESYSYRYSELEANENVAGEPFQRLIRVGGATHLPRVSRYGGGLGRTLGFPVRAGLAHHPQRSTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I955</accession>
    <name>A0A1W1I955_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NSJP_3358</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3358"/>
    <dbReference type="EnsemblBacteria" id="SLM49525">
        <property type="protein sequence ID" value="SLM49525"/>
        <property type="gene ID" value="NSJP_3358"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3358"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="11">
        <location>
            <begin position="7"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="12">
        <location>
            <begin position="466"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="932"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM49525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1118" mass="124823" checksum="DD700FA9084F2EC7" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I985</accession>
    <name>A0A1W1I985_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="9">1.14.19.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_3407</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3407"/>
    <dbReference type="EnsemblBacteria" id="SLM49574">
        <property type="protein sequence ID" value="SLM49574"/>
        <property type="gene ID" value="NSJP_3407"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3407"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="8">
        <location>
            <begin position="43"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="283" mass="32705" checksum="95E16342E5811CC8" modified="2017-06-07" version="1">MPDTKWTSPFAYKTFILFCLVAAVTLIGTPLFGFLYGYTLFDWVVFGFLYIVTGMGITVGYHRLISHRSFECHPWVKAILLIAGGWALQNSALRWCSDHIRHHARTDQEEDPYNAQKGFWHSHCGWLFVNTPHRTENYERQLRKDPMIMWQHRNYHAIVISGLAFPLILGFLHGGIQGAIGCFMLAGMFRMFMVLNSTFAINSLCHMYGTQPHGNGDSSRDSWLISLVSFGEGYHNYHHTYARDYRNGPQWYNFDPSKWIIYSLSLFGLATNLRRLDPTVFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9L5</accession>
    <name>A0A1W1I9L5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">cobQ</name>
        <name evidence="7" type="ORF">NSJP_3537</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3537"/>
    <dbReference type="EnsemblBacteria" id="SLM49704">
        <property type="protein sequence ID" value="SLM49704"/>
        <property type="gene ID" value="NSJP_3537"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3537"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="5">
        <location>
            <begin position="6"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="6">
        <location>
            <begin position="256"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="537" mass="58619" checksum="7C94E82DB4BAE74E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9S9</accession>
    <name>A0A1W1I9S9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49752">
        <property type="protein sequence ID" value="SLM49752"/>
        <property type="gene ID" value="NSJP_3585"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3585"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="1">
        <location>
            <begin position="12"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="166" mass="18306" checksum="FF7BCD098E48D1F3" modified="2017-06-07" version="1">MSQSDVPQNQPLVEYQIDRVVDETSTETRIVVLSRKDGDPDAFPIWIGAAEGHAIKLALDATVTPRPMSHDLIKSFAGHLGVTVHRVVISDVRNSTYYASVHLGNNGVERTLDARPSDALALAVRVQCPIYIAQDVLSRRNTANLDAWLVKLESKRIGAQPEVREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9X9</accession>
    <name>A0A1W1I9X9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3633"/>
    <dbReference type="EnsemblBacteria" id="SLM49800">
        <property type="protein sequence ID" value="SLM49800"/>
        <property type="gene ID" value="NSJP_3633"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3633"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="114" mass="11977" checksum="514FFDE72256863A" modified="2017-06-07" version="1">MITHLSAQASTIGSALLAGCVLVMPMALASAKSSKSSVVVVDATQGPVPSVQAEAVRLKQAGAESVHVKLENISELHDPQLIPLIEGEVQDMLAKNGFSPKQISFERCPKSCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA42</accession>
    <name>A0A1W1IA42_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3693</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3693"/>
    <dbReference type="EnsemblBacteria" id="SLM49860">
        <property type="protein sequence ID" value="SLM49860"/>
        <property type="gene ID" value="NSJP_3693"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3693"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="219"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="338" mass="36794" checksum="9E38351F94CB439F" modified="2017-06-07" version="1">MDVLSEVLKAVKLDGAVFFNGEFSAPWCAREPDSGTMASYLSVRSKHMVIFHLVTEGQAYARVEQDGNRLSLSAGDIVMFPHGDAHLMGNGPPIAPTDSSEQLLRVLSEGLTLSRAGGGGELTKLICGYMTCEPHLSQLFLSGLPSIVKVNIRDHASGQWLEDTLRYSVDQAGASGPGCAAVIAKLSEALFVETLRRYIARLPKSQTGWLAGVRDPQVGKALALLHRQPAFPWTIASLANEVGVSRSVLAERFKHYLSETPIGYLTRWRLQLAAQLLTSTSKSVAEVAGDVGYESEPSFNRAFKREFSLPPARFRTQARPPSRSPSASNQRSVGQKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA77</accession>
    <name>A0A1W1IA77_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Beta-lactamase</fullName>
            <ecNumber evidence="1">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.2.6" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3725"/>
    <dbReference type="EnsemblBacteria" id="SLM49892">
        <property type="protein sequence ID" value="SLM49892"/>
        <property type="gene ID" value="NSJP_3725"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3725"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="197" mass="22088" checksum="72D9330A01E35E20" modified="2017-06-07" version="1">MVKPFYSLHLPWLLCCLLTSCVFDDSSPDRSSPTLPYEESTISIPEIRKAAEQGNPDAQNRLGMLYSEGRGVPQDYIQAKQWFDKAAEKGHPGAQVNLGTLYFQGNGAPESEQMALSWFRRAAAQGDALAFAKLGLMYEQGRGVPQDFIQAHMWYNLSAAHGEKRAIERRDALTKQMTPAQVAEAQRLAREWTPKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAI9</accession>
    <name>A0A1W1IAI9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2 3">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">proC</name>
        <name evidence="6" type="ORF">NSJP_3843</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2 3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3843"/>
    <dbReference type="EnsemblBacteria" id="SLM50010">
        <property type="protein sequence ID" value="SLM50010"/>
        <property type="gene ID" value="NSJP_3843"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3843"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="4">
        <location>
            <begin position="7"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="5">
        <location>
            <begin position="167"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM50010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="276" mass="28689" checksum="9195032DFC629CD4" modified="2017-06-07" version="1">MLQHTARVGFIGAGNMAESLIAGLLHAKLVLPSHLIASDIDPAARDVISGKYHVATTAKNAEAADEADLLVLAVEPQVLDQVLNEIADILPDKTLIVSVAAGYPIARIARHLRGMKRKKIVRAMPNTPSAIREGVTAIAGDEEVPGDELATARSLFETIGHVVVVPERLLDAVTGLSGSGPAYVYILIEALADGGVKMGLPRQTAQLLAAQTVAGAARLVLSSGEHPALLKDRVASPGGTTIAGIHALELGQFRATVTSAVEAATTRSAELGLEHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAK0</accession>
    <name>A0A1W1IAK0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AraC_E_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49941">
        <property type="protein sequence ID" value="SLM49941"/>
        <property type="gene ID" value="NSJP_3774"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3774"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029441">
        <property type="entry name" value="Cass2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14526">
        <property type="entry name" value="Cass2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraC_E_bind" evidence="1">
        <location>
            <begin position="3"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="162" mass="18768" checksum="44E8FE057C57A1CD" modified="2017-06-07" version="1">MTQRPNVTDEDEIRIVGIEVRTSNRLESDRKTARIPGLWQRFYREHIEDQVPHRVADEFIYEAYIDYGSDHNGEYSVVLGVQVDSFDNVPPGMARALLPRSRYLVFPAVGEIPKAVQHAWGNVWNHFTTQAEHRRSFRGDYEKLKKDDKGGFAECNIYISVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAS9</accession>
    <name>A0A1W1IAS9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative iron-regulated membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50102">
        <property type="protein sequence ID" value="SLM50102"/>
        <property type="gene ID" value="NSJP_3935"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3935"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005625">
        <property type="entry name" value="PepSY-ass_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34219">
        <property type="entry name" value="PTHR34219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03929">
        <property type="entry name" value="PepSY_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="400" mass="44811" checksum="8778F977388F20F7" modified="2017-06-07" version="1">MRAIGVTIHRWAGLFTALFLFVSGLTGAVISWDHEIDEWLNDHLFDVSNIGPSIPYLELAARIEAADPRVRVSQVPLQTEPGRSLLFGVQPRVDPQTGKLYKAGYNQVFLDPVTGKELGRREWGAVAVDREHLMAFLYRLHYTLHIPNFAGQNRWGQWFMGGIAIIWLLDCFVALAISFPDRFRWRRSFWIRHGSRYQLNFDLHRAGGLWTWGVLLVLAVSAVYLNLNREIVRPAVAAVATVTPNPFDVRTQRPLNQPIEPRIDYAAAIANAQEEAQRKRWQEPVGAASYNARYGIYQVRFFQPGNDHGSGGFGVRRLYFDGLDGAYLGELIPGSGTAGDLFLQIQFPLHSGRIAGIPGRIFISIMGLVVAGLSVTGVVIWMKRRGRLSAVSAAFRRAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAY5</accession>
    <name>A0A1W1IAY5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain-fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3766"/>
    <dbReference type="EnsemblBacteria" id="SLM49933">
        <property type="protein sequence ID" value="SLM49933"/>
        <property type="gene ID" value="NSJP_3766"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3766"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="50"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="548" mass="59367" checksum="3F0FC2646761E249" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBH2</accession>
    <name>A0A1W1IBH2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase III subunit delta'</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">holB</name>
        <name evidence="9" type="ORF">NSJP_4094</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4094"/>
    <dbReference type="EnsemblBacteria" id="SLM50261">
        <property type="protein sequence ID" value="SLM50261"/>
        <property type="gene ID" value="NSJP_4094"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4094"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004622">
        <property type="entry name" value="DNA_pol_HolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015199">
        <property type="entry name" value="DNA_pol_III_delta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09115">
        <property type="entry name" value="DNApol3-delta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00678">
        <property type="entry name" value="holB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNApol3-delta_C" evidence="8">
        <location>
            <begin position="216"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM50261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="342" mass="38239" checksum="E400A487D5C1849A" modified="2017-06-07" version="1">MPFDEVIGHEATIAALQTAASGGRLAHAYLFHGDVAIGKRLTASRFAQALNCERMETAKPPDACGLCRSCLQIEARTYPDFFVIEPDRELAVPQIKIEEIRNLEQQMVYRPLVGERKICLIDDADRMTIGASNALLKTLEEPPDHSLFLLVSSRPHALPATIRSRCQQLRFGVPSWTRVEAALIRDREKNPADARLLAVFSEGRIGQAFSADAGQLRTRQREILELVNQQTLQSSALLLTAAESLHKSERAQDTLTWLARWIRDVVFVRVGGDPDQLLFAEHIRALEACARQADTDSLLQLLQDIEQTEQQSGRHVNLQIALENILLRLRDAIFPQTPVPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBK2</accession>
    <name>A0A1W1IBK2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_4102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.27" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4102"/>
    <dbReference type="EnsemblBacteria" id="SLM50269">
        <property type="protein sequence ID" value="SLM50269"/>
        <property type="gene ID" value="NSJP_4102"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4102"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="54"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="191" mass="20513" checksum="2BCBB451C5DB7349" modified="2017-06-07" version="1">MSWDEALFRAVNGLAGRSGILDWLALSLSSPDLLWGPAVILGGYWLWLSRQEMIIAAPLLGGVIGVADFLGARIKGLVARPRPCVALPDIHQIETCGKAFGFPSNHAINTAAAAAFLHVLYPRSAWISWPLVAVIGLARVFIGAHYLTDVLGGWLLGGLFGAATAWALLQWPRFRRRPLPSTPSVGVVAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IC15</accession>
    <name>A0A1W1IC15_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD_dependent epimerase/dehydratase protein</fullName>
            <ecNumber evidence="2">5.1.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50313">
        <property type="protein sequence ID" value="SLM50313"/>
        <property type="gene ID" value="NSJP_4146"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4146"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="331" mass="36515" checksum="943930E1BCC673C7" modified="2017-06-07" version="1">MDLMGKKVIVIGGAGLIGSHAVDELIKEDVSEIRIYDNFVRGRQENLHEALKDPRVKIYEVGGDICQTDILDAGMKGMDAVFHFAALWLLQCHEYPRSAFDVNVRGTFNVLEACVANKIKRLVYSSSASVYGDAVEEPMTEDHPFNNKNFYGATKICGEAMARSFHYRYGLDFVGLRYMNVYGPRQDYRGAYIAVIMKMLDAIDRGEGPTILGDGSEAFDFVAVADCGRANVCAMKAETTDRFYNVGTGKRTSLKQLAEMVIDLTGCKAPIKYAPRSQATLVRNRIGSAKRASEEIGFTAKVELKEGLTRLIAWRAAHKEEVAARRAAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZM1</accession>
    <name>A0A1W1HZM1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46208">
        <property type="protein sequence ID" value="SLM46208"/>
        <property type="gene ID" value="NSJP_0036"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0036"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013117003" evidence="1">
        <location>
            <begin position="30"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="307" mass="34126" checksum="42A58C8A70EE9B53" modified="2017-06-07" version="1">MHAPTASVLITAWLAFAALSAPIHVQAQADMVLKHSIQPGESKNYDHTSGIVLSNGFWAKAGSDVTATINQSPGFFVDKTPLDTKDKQYTSNEGRTFVVAGCVPHKLKVKFIGSHWVACNDLDDKKEKVVESKFISCLDLFENGVLQEFFLKEVNNRTWQSFRFSCGELRPDGTVGGQLEKTAFLFDFEKEGKPYTTTVPDNHLSFGILEIYNQLQLRENLLQFAIEHASPEALHEAGEKGRRLEDFNFSDKVPNAFGLGGSIGVIHWQCPPSMVMTGAAIGHVPDKKDKHTRPVYILGECRKLMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZP8</accession>
    <name>A0A1W1HZP8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Thiazole synthase</fullName>
            <ecNumber evidence="4 6">2.8.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">thiG</name>
        <name evidence="8" type="ORF">NSJP_0049</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:26297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12909"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer. Forms heterodimers with either ThiH or ThiS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiG family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.10" evidence="4 6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0049"/>
    <dbReference type="EnsemblBacteria" id="SLM46221">
        <property type="protein sequence ID" value="SLM46221"/>
        <property type="gene ID" value="NSJP_0049"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0049"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990107">
        <property type="term" value="F:thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04728">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00443">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008867">
        <property type="entry name" value="ThiG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34266">
        <property type="entry name" value="PTHR34266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiG" evidence="7">
        <location>
            <begin position="8"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DXP" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="257" mass="27676" checksum="969D555F7ABA1653" modified="2017-06-07" version="1">MYDDRLVIAGREFKSRLWVGTGKYKDFEETKKAIEVSGADVVTVAVRRVNITDRSKENLLDYLDPKKYIILPNTAGCYTVEDAVRYARLARAAGVSDLVKLEVLGDEKTLFPDTVGLLEAAKILVKEGFIVLPYTNDDPIVAKKLVDIGCPAVMPLAAPIGSGLGIRNPYNLKIIMETVKVPIVVDAGVGTASDAALAMEYGADAVLMNTAIAGAQDPIAMAEAMRYAVHAGRLAYKAGRIPRKLYATASSPIEGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZR6</accession>
    <name>A0A1W1HZR6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">UvrABC system protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">uvrA</name>
        <name evidence="16" type="ORF">NSJP_0078</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0078"/>
    <dbReference type="EnsemblBacteria" id="SLM46250">
        <property type="protein sequence ID" value="SLM46250"/>
        <property type="gene ID" value="NSJP_0078"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0078"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UvrA_inter" evidence="15">
        <location>
            <begin position="139"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="UvrA_DNA-bind" evidence="14">
        <location>
            <begin position="293"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="829"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SLM46250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="953" mass="104675" checksum="7F952A8E3C75C446" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I015</accession>
    <name>A0A1W1I015_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0173"/>
    <dbReference type="EnsemblBacteria" id="SLM46345">
        <property type="protein sequence ID" value="SLM46345"/>
        <property type="gene ID" value="NSJP_0173"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0173"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="626" mass="66871" checksum="8EA273EF274F1910" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I029</accession>
    <name>A0A1W1I029_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="5">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="5">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="5">IPP transferase</shortName>
            <shortName evidence="5">IPPT</shortName>
            <shortName evidence="5">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">miaA</name>
        <name evidence="9" type="ORF">NSJP_0179</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5 7">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0179"/>
    <dbReference type="EnsemblBacteria" id="SLM46351">
        <property type="protein sequence ID" value="SLM46351"/>
        <property type="gene ID" value="NSJP_0179"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0179"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="31"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <begin position="54"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="332" mass="37397" checksum="D66DC9F80AFB57AA" modified="2017-06-07" version="1">MDVTPGALLPMSLLTEAQARLKPLVAIVGPTAVGKSRVAVEVAKHFNTEVLTADSRQVYRGMDLGTDKPTVSERQGIPHRLIDLAQPDEPFNAGLYRQHAMEAIEHLHQARLIPLVVGGTGLYVRTLVRGLCEAPPADQAVRIRLQEEVRESGVESLYRRLVAIDPVSASKLHPHDGAKVIRALEVHQLSGKPLSAFHTSHAFGDQPYRTLLIGLDRNRDSLYRRIEARIDWQLDHGFLEETGRLLARGYRRDSAAMKGLGYRQAAEYLAGECDYAEMVRRFKRDTRRFAKRQLTWFRREPAIRWFEIGESESPEHTAARVTELIDLFLAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I092</accession>
    <name>A0A1W1I092_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0246"/>
    <dbReference type="EnsemblBacteria" id="SLM46418">
        <property type="protein sequence ID" value="SLM46418"/>
        <property type="gene ID" value="NSJP_0246"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0246"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="96"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="206"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="377" mass="41796" checksum="7919A7D34978B713" modified="2017-06-07" version="1">MPQAHIDANLVLYFTRGVSLQAWKDAGLLEREVSLYQSMRPHLQGVAFVTYGGESENSLGASVQGIRIVYNKWAVPKRWYGRLMSWVPPWRKKRNVIVKSNQIQGADVAQLAARRYGKPFIARCGYLPSNNAARIYGDHSSQARRARDLERTIFAGADRVVVTTPAIRETILKRYQISPDLVRVIPNYVDTTIFIPEANGGRVANRLMYVGRLDEEKNPLALIEAVRGLSVELLIIGNGSLGERLRREIERENLPVRLLGNIPNHRLPALLTTAAAFIMPSLIEGHPKALLEAMACGSPVIGTDVPGIREVIQHRSNGFLCGTSPVEIRSAIESVLGDRSLQCRMGNSAREYVVHSCSLDRIVEMELELLGELSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0E4</accession>
    <name>A0A1W1I0E4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transporter subunit: membrane component of ABC superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yhhJ</name>
        <name evidence="7" type="ORF">NSJP_0282</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46454">
        <property type="protein sequence ID" value="SLM46454"/>
        <property type="gene ID" value="NSJP_0282"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0282"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="374" mass="41763" checksum="2BBB83EF51F6A574" modified="2017-06-07" version="1">MRSLVNIFWLGIKELKSVLSDKVLIVFVLYAFTWTIYQQATGTSNEVNNASIAFADEDNSALSKELFGAFYPPRFQYPEVIQAGEIERSMDEGRYMFVVVIPPRFERDLRAGRRPEIQLNIDATAMQQAGIGAGYIKNIISQRTETFLKRADVDVREPMNLVMRKLFNPNGLSAWFSSIVGIINQLTLLTIVLTGAAVIREREHGTLEHLLVMPLNAFEIAMAKVWANGLVILIATALSLFLVVRMVLDVPFEGSMPLWFAGVLLYLFFATALGVFLGTISRSMAQFALLIVLMVVVLQLLSGGSTPVESQPAWLQAITYFLPSRHFVSFSQVIIYRGGGFMAVWRNFAMVSAIGLAFFSYSVVLFRKSIAVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0H8</accession>
    <name>A0A1W1I0H8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ndh</name>
        <name evidence="4" type="ORF">NSJP_0333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0333"/>
    <dbReference type="EnsemblBacteria" id="SLM46505">
        <property type="protein sequence ID" value="SLM46505"/>
        <property type="gene ID" value="NSJP_0333"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0333"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="4"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="426" mass="46366" checksum="D5912CEBF9C5C71B" modified="2017-06-07" version="1">MPPKQVVIIGGGFGGLSAARRLRHEQVVLIDRTNHHLFQPLLYQVAMAALSPSDIAWPLRTVFRSQPNVRVVMDEVLSVERAGRVLHVRHSAPIPFEVLILAPGARHAYFGHDEWEESAPGLKTMTDAVLLRQNMLLAFEEAERRAEAGSRERLTFVIIGGGPTGVELAGALAEIGRKAMGPDFPALRLEDLSIVLVEGGPRLLPGFSPDLSAKAATALTRMGVTVRLDSPVRKVDRGSVTIGTEVLPATNILWAAGNRASPLLGTVGVPLDQSGRIKVEPDLTIPGDPWIFAIGDAAHCPGKDGAPLPGLAPVAMQQGRYVAAIIAGGVPPEQRRPFVYRDRGMLATIGRARAVAQIGPVHTSGVFAWLLWCLVHIFFLVGFRNRVRVMSEWIWFYLTFKPGARVLFERPHGFEQDPIVQGKRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0R3</accession>
    <name>A0A1W1I0R3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46567">
        <property type="protein sequence ID" value="SLM46567"/>
        <property type="gene ID" value="NSJP_0395"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0395"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="65" mass="7418" checksum="151F7DA9271D7761" modified="2017-06-07" version="1">MLAWNRKLRESVVLLDQASLCPMDCPMRRKTMIVGTLQPFDVSGEPPGTRTQGPRLKRAMLYRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0X7</accession>
    <name>A0A1W1I0X7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46634">
        <property type="protein sequence ID" value="SLM46634"/>
        <property type="gene ID" value="NSJP_0462"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0462"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012980892" evidence="1">
        <location>
            <begin position="25"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="152" mass="16545" checksum="B6E12F6A45D52A4B" modified="2017-06-07" version="1">MMARRRLGLFVLLCLLCGVSAAQAEGIIEGLFDKAKSSAERKTRDRVNQRIDQTIDKGLNKTEETAQCVATDQECLKRAKEQGKQVNVVATPPADSVKCVATDTSCLKQAKAQGKKVEIVDEAELDTLRCSVTDTDCLGRAKSMGKKVEIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Z1</accession>
    <name>A0A1W1I0Z1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Aminodeoxychorismate lyase</fullName>
            <ecNumber evidence="6">4.1.3.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_0496</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.38" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0496"/>
    <dbReference type="EnsemblBacteria" id="SLM46668">
        <property type="protein sequence ID" value="SLM46668"/>
        <property type="gene ID" value="NSJP_0496"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0496"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008696">
        <property type="term" value="F:4-amino-4-deoxychorismate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="291" mass="32479" checksum="52A2427F4980FCFA" modified="2017-06-07" version="1">MWIYLNDRFVDDANAMISVFDHGLLYGDGVYETIRSYGDQIFMRDEHLDRLRRSADAIGLRVPVAEDDWPALLNEAMQRNDVGNEQIDAYIRITLSRGVGDIGLDPALCPTPTVIVMTKPLSPPPPHQYQSGVDLIVAKTRRNYPGALDPQIKSTSFLNNILAKREAIAAQAFDSLLLNWESHLAECTVSNLFFVTNGRLRTPSLACGILDGITRRIILSLAREEAIRVEEGAYTLDQLVQADECFLTNTTMEVMPVTSVNRGPLGTGKPGPLTRRLHQIFVTNRPRFLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I108</accession>
    <name>A0A1W1I108_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46671">
        <property type="protein sequence ID" value="SLM46671"/>
        <property type="gene ID" value="NSJP_0499"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0499"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012167335" evidence="2">
        <location>
            <begin position="29"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="165" mass="18483" checksum="BD8D3D9B913D3A17" modified="2017-06-07" version="1">MISTHIRYVIICALAAVLAAAGCGGKTAQYPEDHERYLRIDKAIESLRSAYVKKDASGMASLMVPTDQLELLQRDAENDFEAFHHIALEFRVERIMIEGDDIDVHVHWQGVWKKDAEDPGQRQRGHTRLQWVGTKSVLLRGVQGDSPFGMSQRQAGADSIVPSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1C2</accession>
    <name>A0A1W1I1C2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46800">
        <property type="protein sequence ID" value="SLM46800"/>
        <property type="gene ID" value="NSJP_0628"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0628"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="185" mass="20334" checksum="F0770435F7817792" modified="2017-06-07" version="1">MTAISAGCSQHSPSTPANSSGAVSLTHQLPNICPKLGGSYAAIGKASPGYPFFYRVYAWPLSMVRMLGIAAPMNIEKLAIKSELVQNDNLELILWKSDGQRDRHVLITSNDAVSCDQNALKIVRESDTEAEGTLGHVRYTRTFSRGDDGSLRMDVKIEPTTKLLWIIPISQPVEEYQAVFDSLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Q7</accession>
    <name>A0A1W1I1Q7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LapA_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_0755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46927">
        <property type="protein sequence ID" value="SLM46927"/>
        <property type="gene ID" value="NSJP_0755"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0755"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010445">
        <property type="entry name" value="LapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06305">
        <property type="entry name" value="LapA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="LapA_dom" evidence="7">
        <location>
            <begin position="23"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="115" mass="12910" checksum="3C9BFF639D07FC5C" modified="2017-06-07" version="1">MIRLILVGTLLLLCLAFFLQNQEQEVTLRYFFGLFSASTPIYKPILAGFAVGLLVSGILLFPPWVRGRIELRRKTKALQEAEVDLERLRKSLEKLTTKPSSTGVGDSSLRAQTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I200</accession>
    <name>A0A1W1I200_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4105 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0829"/>
    <dbReference type="EnsemblBacteria" id="SLM47001">
        <property type="protein sequence ID" value="SLM47001"/>
        <property type="gene ID" value="NSJP_0829"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0829"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025178">
        <property type="entry name" value="DUF4105"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13387">
        <property type="entry name" value="DUF4105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4105" evidence="2">
        <location>
            <begin position="171"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="673" mass="76443" checksum="0C48990F457DB0BB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I247</accession>
    <name>A0A1W1I247_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47086">
        <property type="protein sequence ID" value="SLM47086"/>
        <property type="gene ID" value="NSJP_0914"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0914"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="76" mass="8682" checksum="C16A9A03833BF520" modified="2017-06-07" version="1">MEMFGRVGLVEIPILIAPDQKVWMDKMIKEGKIAIPPGGTLEKGSLYSMFIRMLLHNAMEEQKRQEAMDADDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I299</accession>
    <name>A0A1W1I299_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 2Fe-2S ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_0771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0771"/>
    <dbReference type="EnsemblBacteria" id="SLM46943">
        <property type="protein sequence ID" value="SLM46943"/>
        <property type="gene ID" value="NSJP_0771"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0771"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="8"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="108" mass="11848" checksum="5FA7B7D59483A389" modified="2017-06-07" version="1">MVTMEGFQLVGSVEDIPPGQSKVVTINNRAIVLFNIEGQYFAIYNICPHEGGPLNEGRLKGFVVSCPWHDLAFDIRNGRGTDGGGYCVGSYEVRVLDGEIFVGPRRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2E4</accession>
    <name>A0A1W1I2E4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DNA polymerase III, delta subunit</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">holA</name>
        <name evidence="3" type="ORF">NSJP_0867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0867"/>
    <dbReference type="EnsemblBacteria" id="SLM47039">
        <property type="protein sequence ID" value="SLM47039"/>
        <property type="gene ID" value="NSJP_0867"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0867"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
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        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="2">
        <location>
            <begin position="23"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="372" mass="40682" checksum="6B911320BF0B5BC9" modified="2017-06-07" version="1">MPPSLSPAQVPSHLQQTTPASIYAVIGEDDLLRDEAVACLKAAVVGEQGDVFNSNQFYGDEADGAEIVACASESAVFASRRLVVVKGADKLPAREGDALLPYFESPNDSTTLVFVAPKLDRRLKFTQALIKSAVAVDCSPPKESQYLSWLKAEAARLGVKLEEEAIELLKESCAESLYAARRELEKLASYVPSNRSVTAADVTVMRGTEPGASVFDLTAAIGAGDRGRALAILARNLESGEAPLKILGALVWQYRRLWKSKDLMRQGGRQGEVARMFRMDPSGVRSFLERFSEQHLTDAFRRFQQTDHALKGGSAGRPERIMDQLMFELCGRERENAPPTVSGREPVAFAQRSRTKPVSNVRTVTRGSRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2F4</accession>
    <name>A0A1W1I2F4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47200">
        <property type="protein sequence ID" value="SLM47200"/>
        <property type="gene ID" value="NSJP_1028"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1028"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="66"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="307" mass="34835" checksum="EADD1895647ED631" modified="2017-06-07" version="1">MEMSRGVKTVGQGRAIGPFGGFTRMIMTLLLAGLLGQSVAALGQESRPENEITSLGEGSYLFRHQFHQAIFITTPKGVIVTDPISAEAATWLKKEIKHYSDQPIRYVVYSHHHDDHITGGSLFADTAVFVSQAGARAKIREAADPLTPLPDLTFTDRMSIDLGGKHVELIYVGKNHSDNSLVVLLPEQRLLFAVDFIPVETVAYRTMKSDYPDDWIESLKRVEQLDFDRLVPGHGKIGNKEHVRMFRGYLEDLRAAVQEQVQKGASLEETKKAVQLPKYERWQRYGDWFPENVEGMYRYLTQRRETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2I3</accession>
    <name>A0A1W1I2I3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1032"/>
    <dbReference type="EnsemblBacteria" id="SLM47204">
        <property type="protein sequence ID" value="SLM47204"/>
        <property type="gene ID" value="NSJP_1032"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1032"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="215"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="318" mass="33790" checksum="E214C1CEEE237740" modified="2017-06-07" version="1">MNEIVGFLMEHGALVVFATVLAEQIGLPVPAVPFLVAAGALAAAGHLNLAVAAGAAVLASLAGDQVWFELGRRRGRQVLGWLCRIAIEPDSCIRRTEDFFSRHGARSLIVAKFIPGLSTIAPPLAGIVGLRLSQFLLFNGVGTILWVGSGLGLGYLFADQLERVLALSASVGPTIGMLAVGAAAGYVAWRVLSRYRGDDPVPHVTPRVVREKLRAGERPVIVDLRPLGARREKAGIPGALPMSADEIVAGQRDLPRDRDVILYCDCPGDAGSIAIARVLRSKGHARVWPLAGGIEAWRAMDVEERETERASASHPMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2N1</accession>
    <name>A0A1W1I2N1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_1080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1080"/>
    <dbReference type="EnsemblBacteria" id="SLM47252">
        <property type="protein sequence ID" value="SLM47252"/>
        <property type="gene ID" value="NSJP_1080"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1080"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="212" mass="23951" checksum="6052FDCFEDAA2C8B" modified="2017-06-07" version="1">MINILLADDHPYLRRGLMQILRDEFPGAVIGEVANVPELLEQVQKLRWDIVVLDLTMPGRGGLEALHELKRLCPNLPILVLSMHPEDQFAVRVLRAGGAGYLTKESVPQEFVRAVRILWKGGKYITPKAAELLAAYVDRHGDTEQPLHDSLSDREYEVFRMIAAGQTITEISEQLALSIKTISTYRSRVLEKLHLSNNVDLARYAVEHHLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2N5</accession>
    <name>A0A1W1I2N5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47083">
        <property type="protein sequence ID" value="SLM47083"/>
        <property type="gene ID" value="NSJP_0911"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0911"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="57" mass="6742" checksum="377ACAA5C00BCC29" modified="2017-06-07" version="1">MRYFLNKSQTRVLRRAKADWIKKESTVDLCRQFFDTPTTFEPKIQRSPASLTGSHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Q4</accession>
    <name>A0A1W1I2Q4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0987"/>
    <dbReference type="EnsemblBacteria" id="SLM47159">
        <property type="protein sequence ID" value="SLM47159"/>
        <property type="gene ID" value="NSJP_0987"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0987"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="42"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="249" mass="28799" checksum="E786D4660556C1B5" modified="2017-06-07" version="1">MKTMREFDVKGADGRSIRGDVAEGAERQVLFITGFLSRRWGGKSKALAQWCMERGWGFCCYDVRGFGESEGTFTDYSLSDWLDDARVVLSMLKQGPPVTIVGNSLGGWIAWLMAREFDRIDRLILIAPAFNMMGIRARDIPDQRRRDWIRLGSMPWDDDPLHKDWPLSWKWVEESEALWNTNFDRLRPVRTSIMHGLEDTAIAPEGSRRFVEQLRMRVPSFPVELQFVSGDHRLSGPEHIELLRRLLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Q8</accession>
    <name>A0A1W1I2Q8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Response regulator, CheY-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1115"/>
    <dbReference type="EnsemblBacteria" id="SLM47287">
        <property type="protein sequence ID" value="SLM47287"/>
        <property type="gene ID" value="NSJP_1115"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1115"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="132" mass="14484" checksum="542A4D0FB7F91737" modified="2017-06-07" version="1">MLHRHAEVVLIVEDDREMRSLLCDEFWSAGYQLREARDGDEAFQAVLQSVPDLILTDLRMPAGGAEYISRLRTVAPACPIVVMTAFGDPAVKAAVLQAGATVYFDKPVRVGELKACIEQLLLDAQSLPRSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Q9</accession>
    <name>A0A1W1I2Q9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Histidine kinase</fullName>
            <ecNumber evidence="5">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_1116</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1116"/>
    <dbReference type="EnsemblBacteria" id="SLM47288">
        <property type="protein sequence ID" value="SLM47288"/>
        <property type="gene ID" value="NSJP_1116"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1116"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="167"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="308"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="525" mass="57132" checksum="61C7D82A36FF189C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2R5</accession>
    <name>A0A1W1I2R5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_1125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1125"/>
    <dbReference type="EnsemblBacteria" id="SLM47297">
        <property type="protein sequence ID" value="SLM47297"/>
        <property type="gene ID" value="NSJP_1125"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1125"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="221" mass="24047" checksum="2E7AAFC977680B15" modified="2017-06-07" version="1">MAEPYRILLADDHVLVAEGIQKLLEPEFQLVGIVADGRALIAEAAKLQPDIVVVDISLPLLNGLDASAQLKKHQPDLKIIVLTMHSEQNFVTQAFRVGASGYVLKQSVGSELVQAIREVIKGRTFVSPMVAQSLVDQAVNKSSSETSVDAERAFAPTLSSRQREVLQLVAEGKATKEIASILNVSVKTVEFHKTRIMKELRLRTAAELTKYAIAAGLTSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2X8</accession>
    <name>A0A1W1I2X8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NSJP_1188</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1188"/>
    <dbReference type="EnsemblBacteria" id="SLM47360">
        <property type="protein sequence ID" value="SLM47360"/>
        <property type="gene ID" value="NSJP_1188"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1188"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
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        <property type="match status" value="1"/>
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        <property type="match status" value="12"/>
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        <property type="match status" value="3"/>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="114"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
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            <begin position="211"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="303"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="395"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
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            <end position="539"/>
        </location>
    </feature>
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            <end position="631"/>
        </location>
    </feature>
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        <location>
            <begin position="671"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="763"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
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            <end position="907"/>
        </location>
    </feature>
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        <location>
            <begin position="947"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="1039"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="1131"/>
            <end position="1183"/>
        </location>
    </feature>
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        <location>
            <begin position="1427"/>
            <end position="1660"/>
        </location>
    </feature>
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        <location>
            <begin position="1708"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="1830"/>
            <end position="1946"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="1976"/>
            <end position="2093"/>
        </location>
    </feature>
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        <location>
            <begin position="1351"/>
            <end position="1417"/>
        </location>
    </feature>
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            <position position="1757"/>
        </location>
    </feature>
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            <position position="1879"/>
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    </feature>
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            <position position="2026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM47360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="2095" mass="226652" checksum="23022E7451F5CF2E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I302</accession>
    <name>A0A1W1I302_9BACT</name>
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        <submittedName>
            <fullName evidence="6">Sigma-54 dependent transcriptional regulator (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1031</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1325564.NSJP_1031"/>
    <dbReference type="EnsemblBacteria" id="SLM47203">
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    <dbReference type="KEGG" id="nja:NSJP_1031"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Homeobox-like_sf"/>
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        <property type="entry name" value="HTH_Fis"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="860" mass="95472" checksum="B8DA65B4817CC8DE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I310</accession>
    <name>A0A1W1I310_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1183"/>
    <dbReference type="EnsemblBacteria" id="SLM47355">
        <property type="protein sequence ID" value="SLM47355"/>
        <property type="gene ID" value="NSJP_1183"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1183"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="DUF5985"/>
    </dbReference>
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        <property type="entry name" value="DUF5985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="96" mass="10624" checksum="B806FB1C1EAB3C85" modified="2017-06-07" version="1">MHDVGVFLLGGLAMGDLIAGLFFLRYWIVTQDRFFLYFAAAFAIQMVCRMLLIGTTANSESEPLVYVFRLLSYGVILAGIFDKNRAKIAKALSGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I337</accession>
    <name>A0A1W1I337_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47404">
        <property type="protein sequence ID" value="SLM47404"/>
        <property type="gene ID" value="NSJP_1232"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1232"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="39" mass="4354" checksum="59D7B53CCB37E602" modified="2017-06-07" version="1">MVGSRLAVFATLRNLGELRLGPKEPFELSDTFTRTALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3A8</accession>
    <name>A0A1W1I3A8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable cytosol aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucine aminopeptidase</fullName>
            <shortName evidence="8">LAP</shortName>
            <ecNumber evidence="8">3.4.11.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Leucyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">pepA</name>
        <name evidence="10" type="ORF">NSJP_1318</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.</text>
            <dbReference type="EC" id="3.4.11.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="8"/>
    <dbReference type="EC" id="3.4.11.10" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1318"/>
    <dbReference type="EnsemblBacteria" id="SLM47490">
        <property type="protein sequence ID" value="SLM47490"/>
        <property type="gene ID" value="NSJP_1318"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1318"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="9">
        <location>
            <begin position="351"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="503" mass="54735" checksum="BDA396A889B7C106" modified="2017-06-07" version="1">MKLMQVQVKVGRPESEAVEVLALMHCEGEALAKQDAGALDKALGGSLQSLLRSGEFEGRTGEVMLFHTHGKVPAKRLLLIGLGKKNSLRLDTLRQAMGHAAKRARQAKVDAFTVCYPTATPKGHSPVEIAQAMTEGAVLGGYQFTTYRSEDTAAKDIGLMTLLMPQKSQVRQGTEGVRRGLATAEAAMFVRDLCNHPSNVMTPARIADEAKAIAKQEQLTLKILEQKDMEQLGMGALLGVARGSHEPPKFLILEYNRARKKDERPVVFVGKTITFDTGGISLKPAENMEHMKADMTGGAEVLAAIRAASRLKLPLRLISILPVAENMPGGRAMKPGDIVKTLSGKTVEVQNTDAEGRLILSDALFYAQRYNPAALVDIATLTGACVVALGQFAIGMFGTDARLKDQVRKSGMTAGERVWEMPLWDEYFEQLRSDVADMRNIGGRGGGMITAALFLSKFAGDYPWVHLDIASTDWSERERAYIPKGPTGIGTRLLIQYLIDRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3A9</accession>
    <name>A0A1W1I3A9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Haloacid dehalogenase superfamily hydrolase, subfamily IB, PSPase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1316"/>
    <dbReference type="EnsemblBacteria" id="SLM47488">
        <property type="protein sequence ID" value="SLM47488"/>
        <property type="gene ID" value="NSJP_1316"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1316"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="229" mass="25598" checksum="BE743A4C7B6F52D2" modified="2017-06-07" version="1">MTPAHMLSRPRTGTQVAAFFDLDNTLLPGEASEVRFFRSLWRRKVVGWPELKASAGWLIRHLPALSLQPLRERKLYLAGKPAQVIEPLGEEFCREELCPVVAADGMSRMEEHRRAGHRIVLITGSLDFLVQPIAEALRVDQSIAAVLEEADGLYTGRLVAPLPYGEEKRVLIQRLAAELDLDLASCFAYGDSPGDLEILKSVGHPMVVNPIRGMGTLAVQYHWPVVRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3D3</accession>
    <name>A0A1W1I3D3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein LiaR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">liaR</name>
        <name evidence="5" type="ORF">NSJP_1217</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1217"/>
    <dbReference type="EnsemblBacteria" id="SLM47389">
        <property type="protein sequence ID" value="SLM47389"/>
        <property type="gene ID" value="NSJP_1217"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1217"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="223" mass="25007" checksum="E1314624355AB1AA" modified="2017-06-07" version="1">MEKIKVLIADDHRVVREGLAAILKTKDDIQVVGEAQDGMEAVEKTRTLLPDVILMDVSMPRMGGVEATRQVKREFPHIGIVALTMYEEQQYIFDLVRAGATGYLLKDSESSQIVAAIRAIYRGESLIHPSVASKILAEFSLMAQKKGKKPAWVEHDLTEREITVLRLVADGKTNKEIANSLDLSEKTVKNHVRNIFHKLQVYDRTQAAILAIRKGLIELDPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3I1</accession>
    <name>A0A1W1I3I1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO</fullName>
            <ecNumber evidence="10">2.1.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Folate-dependent tRNA (uracil-5-)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Folate-dependent tRNA(M-5-U54)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">trmFO</name>
        <name evidence="12" type="ORF">NSJP_1349</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:16873"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.74"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:62372"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.74"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MnmG family. TrmFO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.74" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1349"/>
    <dbReference type="EnsemblBacteria" id="SLM47521">
        <property type="protein sequence ID" value="SLM47521"/>
        <property type="gene ID" value="NSJP_1349"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1349"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030698">
        <property type="term" value="F:5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047151">
        <property type="term" value="F:methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01037">
        <property type="entry name" value="TrmFO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004417">
        <property type="entry name" value="TrmFO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF2">
        <property type="entry name" value="PTHR11806:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00137">
        <property type="entry name" value="gid_trmFO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 10 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GIDA" evidence="11">
        <location>
            <begin position="18"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="23"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM47521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="452" mass="49213" checksum="7FFA2459B386B05F" modified="2017-06-07" version="1">MQPFTVHPIVGLLSMRQDIVVIGGGLAGSEAAWQAANRGAKVTLYEMRPKEMTPAHKTGDLAELVCSNSLGSVDSSTAPGILKEEMRRLGSLIIRAAEQARVPAGTALAVDRELFSSHVTRALASHANIRIMHEEIADIPRDCVCIVATGPLTSDKLSQAIGGLAQSRHLYFYDAISPIVDADSIDMNVAFRASRYQKGGDDYLNCPMDEPTYDKFYEALLAAEKVQPKEFEKTPYFEACLPIEVMAERGRQTMQFGPLKPVGLVDPRSGRRPFAVVQLRTENSHGSCYNLVGFQTKLTYGEQKRVFRMIPGLEQAEFLRYGSLHRNTFINAPQLLRNTLQFKGRESLLFAGQLVGVEGYTDSAAMGGLAGINAARVLTGEALLSPPPTTAHGSLVAHITTSDAGNFQPMNANFGLFPPLAASIRDKSQKRRLIAERALTDFAAWMAQSGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3L5</accession>
    <name>A0A1W1I3L5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47596">
        <property type="protein sequence ID" value="SLM47596"/>
        <property type="gene ID" value="NSJP_1424"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1424"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="140" mass="15305" checksum="BCD65F9F8F3B61CD" modified="2017-06-07" version="1">MTATDVLETVGGLTSQLKAYAVKLPSIVFLTVVPTGIKPTPEAIEEYEHIVSRFRQQSAGTSYKGLNELLVESLEAFEVGKLLGSVQPLLAVLDHLERMQRDKEAEVGRTDEKRLSDYRAALNKILPGNKPELDGAGRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3P2</accession>
    <name>A0A1W1I3P2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">fmt</name>
        <name evidence="11" type="ORF">NSJP_1448</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1448"/>
    <dbReference type="EnsemblBacteria" id="SLM47620">
        <property type="protein sequence ID" value="SLM47620"/>
        <property type="gene ID" value="NSJP_1448"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1448"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="10">
        <location>
            <begin position="204"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM47620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="314" mass="33863" checksum="69257FCBBDDE6A72" modified="2017-06-07" version="1">MRVIFMGTPDFAVPSLEALLNSDDEVVGVVTQPDRPKGRGQTMTFSPVKDLAVGRQIPILQPTKMKDPDFLAALQKWDADVIAVAAFGRILPPSILSLPRHGCLNVHGSLLPRYRGAAPIQWAIIEGETETGITTMLMDEGMDTGAILLQERMAIEPQDTAGSLSVRMAALGGRLLSETMKHLKSGTLMPSPQDDRQATLAPILKKEDGLIDWNEPARSLANRIRGLSPWPGAYTFSHADRWVLWKAAPLSEPASAAPGTIVDVTKQALHIATGDGLLAVNELQVANSRRMMVAQYLAGHPIQPGLRLGVPSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3V5</accession>
    <name>A0A1W1I3V5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47655">
        <property type="protein sequence ID" value="SLM47655"/>
        <property type="gene ID" value="NSJP_1483"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1483"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.550">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013580">
        <property type="entry name" value="LI-POR_suB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042298">
        <property type="entry name" value="P-CP_red_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08369">
        <property type="entry name" value="PCP_red"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCP_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="PCP_red" evidence="1">
        <location>
            <begin position="87"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="PCP_red" evidence="1">
        <location>
            <begin position="207"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="333" mass="37657" checksum="7134152BF6C6EB2B" modified="2017-06-07" version="1">MSASDADDTAVTDVRWTDGALKRMDRAPMFLRGMVRRLAEKKARELGLAEITETTLDQFKNQMMGRMGGESGMADAAAQMEQGHLPWTAAAKERLNTVPEFMRGMIKQIAEEVAKEGGHLEVNIDLFEKVEAMGDMRDSALAALPWTEDALAALQEKVKQSPPIAVEFVTDMLKHDTEDLAREKGLTQITGEVLRNLWDEPQERVAWTDEAWKRLQTSPDFVRSGIRKAAERRARKLGLKEIDSDHLTTFRNQAMMKAVKRIRSFGYNELTFDAFDTALEKTKRLKGNEQAELRLKEIRGHFADPETKKPEGGTLGAELMDRFRRYLKGEGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Y6</accession>
    <name>A0A1W1I3Y6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1407"/>
    <dbReference type="EnsemblBacteria" id="SLM47579">
        <property type="protein sequence ID" value="SLM47579"/>
        <property type="gene ID" value="NSJP_1407"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1407"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="95" mass="10156" checksum="8E104AF846A32E49" modified="2017-06-07" version="1">MVFDAQSTKTLSQRGRGVTTCVKDGIRALCLAALAGYRYGISPWLGPACRFEPTCSAYASEAITRFGVGRGAALTVCRLLKCHPFHPGGHDPVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I404</accession>
    <name>A0A1W1I404_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">dapB</name>
        <name evidence="12" type="ORF">NSJP_1533</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1533"/>
    <dbReference type="EnsemblBacteria" id="SLM47705">
        <property type="protein sequence ID" value="SLM47705"/>
        <property type="gene ID" value="NSJP_1533"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1533"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="116"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM47705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="255" mass="27047" checksum="74514D50AF58E4CA" modified="2017-06-07" version="1">MGCRLVSLLKESTTLKLAGAIEGAKHPTLGQDAGEIAGCGRAGVPITDDLPLLLERGDVVVDFSSPHATLDHLRVVAQHRRAMVIGTTGFSASEIQQIRDFAAQIPCVLSPNMSVGVNLICKVIAEMAKTLGDGYDIEVIEAHHRLKKDAPSGTALKLAEVLADAVGRNLAQVGVYERKGLIGERKNTEIGIQTVRAGDIVGDHTVLFGGIGERIEVIHRASSRDTFASGALRAAGWVAGRQPGLYDMMDVLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I451</accession>
    <name>A0A1W1I451_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acyl-L-homoserine lactone synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aubI</name>
        <name evidence="2" type="ORF">NSJP_1610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1610"/>
    <dbReference type="EnsemblBacteria" id="SLM47782">
        <property type="protein sequence ID" value="SLM47782"/>
        <property type="gene ID" value="NSJP_1610"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1610"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001690">
        <property type="entry name" value="Autoind_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00765">
        <property type="entry name" value="Autoind_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01549">
        <property type="entry name" value="AUTOINDCRSYN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51187">
        <property type="entry name" value="AUTOINDUCER_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0071">Autoinducer synthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="245" mass="27358" checksum="ABC9DD3D4342B9F0" modified="2017-06-07" version="1">MSDSMVVAEEKRIFFHEGAFSVKTLETESEWCQAYRLRHRVFAERLKWVPERPDRLEADMYDAWSTSIGVFTADSILLGLVRMTHAPVPFMLESEFSACLTGTHPIRKELDTAEITRLAVDPHVADRTVSTRVMQAAIKGAYLWCVANDVRYTYIVVEERLLRGLRLMGWPCQSLGAPVSLPPAQAVSVAALIDLETFRLNASAKRPEVLKWYSTAETVSTGASRCDSPVRASASEVGDVQYEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I467</accession>
    <name>A0A1W1I467_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47659">
        <property type="protein sequence ID" value="SLM47659"/>
        <property type="gene ID" value="NSJP_1487"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1487"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="67" mass="6985" checksum="AB0EDB5C9E1B28BD" modified="2017-06-07" version="1">MARSFTWWFGIGALLTLSVLMVQGGVRDLIDGTHPAGGTNPYLSFGTTIFGGGLLAGCLALVMKRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I477</accession>
    <name>A0A1W1I477_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH-quinone oxidoreductase subunit C/D 2</fullName>
            <ecNumber evidence="11">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">nuoC</name>
        <name evidence="11" type="ORF">NSJP_1632</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="11"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1632"/>
    <dbReference type="EnsemblBacteria" id="SLM47804">
        <property type="protein sequence ID" value="SLM47804"/>
        <property type="gene ID" value="NSJP_1632"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1632"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030964">
        <property type="term" value="C:NADH dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01397">
        <property type="entry name" value="NDH1_NuoCD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026662">
        <property type="entry name" value="NDH-1_subunit_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="9">
        <location>
            <begin position="31"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="10">
        <location>
            <begin position="314"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM47804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="584" mass="66811" checksum="E2D6A30A38AECCF0" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4E8</accession>
    <name>A0A1W1I4E8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47693">
        <property type="protein sequence ID" value="SLM47693"/>
        <property type="gene ID" value="NSJP_1521"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1521"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMP_b-brl" evidence="1">
        <location>
            <begin position="34"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="184" mass="19954" checksum="CB2C9DF73BDA94DE" modified="2017-06-07" version="1">MPSFLSSLFIRTSIVAAILTGSMVVSRPALADDRWGFGSGLGFTAGTVNNTVFTLGFNLDYYFDRDFSVGPMMLLTPTGDLFQIAFAGAARYHLRLDNGINLVPFIGFGLIHVDLDKGTGPGSIDRNDTSWYLPIGLSLEYQLARKIALTSSLIVNLHDINLSPSLPDHDTTSVTLLFGFNFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4I7</accession>
    <name>A0A1W1I4I7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1617"/>
    <dbReference type="EnsemblBacteria" id="SLM47789">
        <property type="protein sequence ID" value="SLM47789"/>
        <property type="gene ID" value="NSJP_1617"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1617"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="163" mass="18289" checksum="47ADB3DF2D96AA7A" modified="2017-06-07" version="1">MPTASSVRFPPIRIMRPEDREPVIRLLLASQPWKRLGHTAADWNRYFAPLPQGRDSYVVDQDGLAAGVAVVRQKFLLGDYLELFGVAEAARSRGLGGRLLAYVESLVFARAKNLFICVSDFNEPARRFYRKHGYQEIGAIPDLLIPGSAEMLLRKTSGPSMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4J3</accession>
    <name>A0A1W1I4J3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="13">2.7.8.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pgsA</name>
        <name evidence="13" type="ORF">NSJP_1748</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="13"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1748"/>
    <dbReference type="EnsemblBacteria" id="SLM47920">
        <property type="protein sequence ID" value="SLM47920"/>
        <property type="gene ID" value="NSJP_1748"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1748"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM47920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="178" mass="19540" checksum="C1411922E0FD2AE3" modified="2017-06-07" version="1">MNIPNSLTLLRILLIPVYIGLLVYEEFDQALLVLLAAGVTDALDGTIARAANQKTRLGAFLDPLADKLLLTSGFITLSTIHLIPSWVTILVVSRDVMLLLGTAVAQLTETEIDITPTFLGKGTTFLQLSYVLLVIFLSSRQIDLQYLHPLLFGMAAFTLLSGFHYLYRGYRRAGSVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4J5</accession>
    <name>A0A1W1I4J5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonucleoside-diphosphate reductase subunit beta</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_1689</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="3 5">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1689"/>
    <dbReference type="EnsemblBacteria" id="SLM47861">
        <property type="protein sequence ID" value="SLM47861"/>
        <property type="gene ID" value="NSJP_1689"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1689"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000355">
        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="340" mass="38841" checksum="C9BE7A2550E11570" modified="2017-06-07" version="1">MSHVKRPARLLDPGMCLTLRPMAYPVFFDMYRSAIKNTWTVEEVDFSTDVGDLRTKMSAAERHLVQRLVAFFATGDSIVANNLVLNLYEHINAPEARMYLSRQLYEEALHVQFYLTLLDTYVPDPDERFSAFAAVETIPSIRRKAEFCFRWMDSIHRLDALDSREKRSRFLRNLVCFAACIEGLFFFAAFAYVYFLRSRGLLHGLASGTNWVFRDESAHMAFAFEVVSQVRREEPELFDGAFEADIGLMMDEAVACETAFAEDLLGGGVAGLSLRDVRQYLQFVADQRLTTLGLRKRYGAKNPFTFMDLQDVQEVANFFERRVSAYQVGVTGDVAFDAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4L7</accession>
    <name>A0A1W1I4L7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47958">
        <property type="protein sequence ID" value="SLM47958"/>
        <property type="gene ID" value="NSJP_1786"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1786"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="64" mass="6951" checksum="EBB5816B746B3699" modified="2017-06-07" version="1">MSVMLGARVHARLCRGFPQVENGVRANGLSKDVMLGLLSAIVGLLRSCVDYQEVIDFDTVVSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Q0</accession>
    <name>A0A1W1I4Q0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-aspartate oxidase</fullName>
            <ecNumber evidence="4">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">sdhA or nadB</name>
        <name evidence="11" type="ORF">NSJP_1804</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1804"/>
    <dbReference type="EnsemblBacteria" id="SLM47976">
        <property type="protein sequence ID" value="SLM47976"/>
        <property type="gene ID" value="NSJP_1804"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1804"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="10">
        <location>
            <begin position="86"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM47976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="527" mass="56913" checksum="20403E1AEE7C3F7A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I575</accession>
    <name>A0A1W1I575_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate:ferredoxin oxidoreductase gamma subunit</fullName>
            <ecNumber evidence="3">1.2.7.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">porC</name>
        <name evidence="3" type="ORF">NSJP_1992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.1" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1992"/>
    <dbReference type="EnsemblBacteria" id="SLM48164">
        <property type="protein sequence ID" value="SLM48164"/>
        <property type="gene ID" value="NSJP_1992"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1992"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011894">
        <property type="entry name" value="PorC_KorC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02175">
        <property type="entry name" value="PorC_KorC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="14"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="235" mass="25646" checksum="1488CF773FA5ECEC" modified="2017-06-07" version="1">MIKKRINIRMSGLGGQGAVTAAHVMAMAANRDGKFSISNPFFGAEKRMAPAESYCRIGIERIYDRGELVFPDVIQVFHPQVITMGKSYTMPFYSGIKEGGVVIINSDVPLLSEEDIQRLKDLNVALFYIPGTQIAIEIAGTELSTNMTMIGSVAGITKCVSMEALDGALQERFGKKFVASGGTASLDEAIKKKFAKKEMLLQKNFATVKRAYEIATEWAEKNKIELRVGNPAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5P6</accession>
    <name>A0A1W1I5P6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">mreB</name>
        <name evidence="3" type="ORF">NSJP_2027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2027"/>
    <dbReference type="EnsemblBacteria" id="SLM48199">
        <property type="protein sequence ID" value="SLM48199"/>
        <property type="gene ID" value="NSJP_2027"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2027"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="213"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="293"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="349" mass="37635" checksum="E135AF9DC091EE61" modified="2017-06-07" version="1">MGLASDIFGWFSNDLAIDLGTATTLVYVHGKGIVLNEPSVVAVEKKTEKVLAVGADAKKMLGRTPGNIVAVRPMKEGVIADFEMAEQMLKRFIQKAHNRSAFVRPRIIIGVPSRITQVEQRAVRDSAELAGAREVYLIEEPVAAAIGAGLPITEPSGNMVVDIGGGTTDIAVISLGGIVYSESVKVAGDRMDDAIMNYIKKKYNLLIGEHMAERIKFEIGSAYPFEERKTMMIKGRDLISGIPRTLVVDDAEIREALQEPIGTIVNAIKVALENTPPELAGDIIDRGIVLTGGGSLLKGMDTRFREETNLPIITVDDPLTSVVLGVGKILDELDLLAKVAVMSQANTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5P8</accession>
    <name>A0A1W1I5P8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative DNA mismatch repair protein, MutS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_2164</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2164"/>
    <dbReference type="EnsemblBacteria" id="SLM48336">
        <property type="protein sequence ID" value="SLM48336"/>
        <property type="gene ID" value="NSJP_2164"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2164"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="4">
        <location>
            <begin position="422"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="609" mass="67276" checksum="A21A9D1CAA035CDA" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I605</accession>
    <name>A0A1W1I605_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin, 2Fe-2S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2270"/>
    <dbReference type="EnsemblBacteria" id="SLM48442">
        <property type="protein sequence ID" value="SLM48442"/>
        <property type="gene ID" value="NSJP_2270"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2270"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="116" mass="12920" checksum="29F565AA3604ED0E" modified="2017-06-07" version="1">MPSFARHIFVCTNQRSADDPRGSCSLLGSEALHAKFKQETKRLNLKNVVRANKAGCLDHCAQGPSVVVYPEGVWYTVRSEADVTEIMERHVMRGEIVTRLIMPDHPAPSKLPPLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I620</accession>
    <name>A0A1W1I620_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HPt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2253"/>
    <dbReference type="EnsemblBacteria" id="SLM48425">
        <property type="protein sequence ID" value="SLM48425"/>
        <property type="gene ID" value="NSJP_2253"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2253"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="2">
        <location>
            <begin position="17"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="114" mass="13097" checksum="F8710067CC8B351A" modified="2017-06-07" version="1">MTQPAQQSDPDFITVTIDPDLEEIVPVFMRNRRRDVGTLRTALDESDFKTVRLLGHRMKGDGGGYGFNTISEIGEVLEQAAIREDRPAITQQTDRLDDFLDRVQVVYRKHGHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6E4</accession>
    <name>A0A1W1I6E4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DnaK suppressor protein (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dksA</name>
        <name evidence="7" type="ORF">NSJP_2277</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2277"/>
    <dbReference type="EnsemblBacteria" id="SLM48449">
        <property type="protein sequence ID" value="SLM48449"/>
        <property type="gene ID" value="NSJP_2277"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2277"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="6">
        <location>
            <begin position="109"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="193" mass="21912" checksum="DE9465CC525F59BB" modified="2017-06-07" version="1">MATKTPAKKKPAMKSKPTVKPVAKSTNVNPPEAVIEKLEVPEKPSSVAVSPLAAKPKESPKEREARERRRDALQKMLMRKRQEIIKEIEGSLGQSLTEDQQRRLESARDVGDQALMDLDRELGISLMEMRNRRRQAMDEALVRLSEGTYGICAECGVEISERRLEAVPFAKLCVECQSREELLEKIEKEEERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6F2</accession>
    <name>A0A1W1I6F2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Ribonuclease H</fullName>
            <shortName evidence="5">RNase H</shortName>
            <ecNumber evidence="4 5">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rnhA</name>
        <name evidence="8" type="ORF">NSJP_2415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4 5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2415"/>
    <dbReference type="EnsemblBacteria" id="SLM48587">
        <property type="protein sequence ID" value="SLM48587"/>
        <property type="gene ID" value="NSJP_2415"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2415"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09278">
        <property type="entry name" value="RNase_HI_prokaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00042">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022892">
        <property type="entry name" value="RNaseHI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="161" mass="18031" checksum="33D3D26ABE4DCF77" modified="2017-06-07" version="1">MIEIYADGACSGNPGPGGWGVLLRVNEIETELCGGEPATTNNRMELLAVIHALQSFPEPMEAHVYTDSQYVQKGISEWIHSWKRRGWKTAGRDPVKNEDLWRRLDALAARHVLEWHWVKGHAGHPENERADALARAGLEQARRTGHRSGSAADSPPYDRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6G0</accession>
    <name>A0A1W1I6G0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine synthetase</fullName>
            <ecNumber evidence="4">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glnA</name>
        <name evidence="6" type="ORF">NSJP_2402</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2402"/>
    <dbReference type="EnsemblBacteria" id="SLM48574">
        <property type="protein sequence ID" value="SLM48574"/>
        <property type="gene ID" value="NSJP_2402"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2402"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="5">
        <location>
            <begin position="102"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="2">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="469" mass="52923" checksum="A695B9B3DBD14800" modified="2017-06-07" version="1">MNVREVLEFAKKNKVQVVDLKFVDLIGTWQHFTIPASELTEDLFKDGSGLDGSSIRGWRAINNSDMLVVPDPSTACMDPFTAVPTLSLTGNVIDPISRENYERDPRYIAQKAEKYLQSTKIGDISFWGPEAEFFIFDHARYDQTGHSGYYFIDSEEGVWNMGQDGVNLGAKIRHKEGYFPVAPTDTQQDIRTEMIMEMEKVGIAVEKHHHEVATAGQAEIDVRFDSLLKMADKMMMYKYIVKNVARRHGKTVTFMPKPIFGDNGSGMHTHQSIWKDGKPLFAGKDYAGVSQMCLYYIGGILKHAPALAAITNPTTNSYKRLTPGFEAPVLLAYSSRNRSAGIRIPMYSPSPKAKRIEVRFPDPGCNPYLAFAAMLMAGLDGIENKINPGEPAEKDLYDLEAKEAAKIRTMPGSLDEALNNLEKDHKFMLKGGVFTEDVIEAWINYKRTKEVDPMRLRPHPYEFFLYYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6G8</accession>
    <name>A0A1W1I6G8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48433">
        <property type="protein sequence ID" value="SLM48433"/>
        <property type="gene ID" value="NSJP_2261"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2261"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="219" mass="24314" checksum="27EA9CC774EBEA2A" modified="2017-06-07" version="1">MTPRRGETVNRSQLQWRLAVSSLLCAVTLLDPDLSLAARDLVAPKEQSDTEIDPTLLPSFDDQKKGIPQAIFVWIKMAKGYDVEWDSFGRKGWYTQDPRLKPIDPGTVFTPDTPAIYIVFEVAPLEDPAQFSAQWFLEGPDRTISASPIGKDTLEVPGHERYGFLELKRPGDKWATGTYLAKLFITPLGQQPFHAVNQVGTMRFTVAEASSSGQTGSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6H7</accession>
    <name>A0A1W1I6H7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">ribH</name>
        <name evidence="9" type="ORF">NSJP_2440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2440"/>
    <dbReference type="EnsemblBacteria" id="SLM48612">
        <property type="protein sequence ID" value="SLM48612"/>
        <property type="gene ID" value="NSJP_2440"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2440"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="85"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="178" mass="19009" checksum="0565274F56A59EBC" modified="2017-06-07" version="1">MKLRKGSHNATGLKFGIVVAKFNKFVTSKLLSSCLDGLMKHGVVEQDVEVVRVPGAFEIPLIARTLAATKRFDAVICLGAVIRGDTPHFDYISGEASRGIGQAALDADVPIIFGVLTTDTVAQAIERADPAKFNRGGEAAKSAIEMATVMRALRVGDAPSAEKLKHDGVRRPARRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6K4</accession>
    <name>A0A1W1I6K4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2389"/>
    <dbReference type="EnsemblBacteria" id="SLM48561">
        <property type="protein sequence ID" value="SLM48561"/>
        <property type="gene ID" value="NSJP_2389"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2389"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011486">
        <property type="entry name" value="BBP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07642">
        <property type="entry name" value="BBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="438" mass="48309" checksum="0CAC42006B7735F4" modified="2017-06-07" version="1">MHGPTVSEVARHRMRRVSVRVLASFFALVLSGVTGYVIDARADGPVHVPFERLEHLGLRVKETEEAIEKTIVSKSLGLKFYGYLEGSYTQNFNNPSNRINQLRIFDVNSNEFRPNLAQLVLEREAKSDGSGLDRLGGKVKFNAGRDSDFIGGMNLSDWADFQEVYAQYIVPVGAGLDIKLGQVNSLVGYEVVESPYNGNYSRSWLFGLGQPFTTRGVRGTYAFDKHVSLSVGVIAFINSARANTRYDPLTEAALTISPSDRVTLVLYNLLGQRPGAVGTPGGMLVQVGGYLSLHLTDRASAIIESYYANQANSSTISPAGNARWNGVAGYLIYDMTKEWGIRVRSELYEDAGGFTTCEGTTAYQPRANVCFGATSTTSAPPVGQTLWEVTTTLQYKPFKSLTTRLEYRYDKSNQHVFQIGERAATYQPTLSLDVIYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6N2</accession>
    <name>A0A1W1I6N2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48591">
        <property type="protein sequence ID" value="SLM48591"/>
        <property type="gene ID" value="NSJP_2419"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2419"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="108" mass="11826" checksum="5676FA8E682CCB55" modified="2017-06-07" version="1">MRLALVFLCFAILPGCLNITNELQPSNPEVKGVLQGEDCTPIVLGMALGTNTIENAKRDGRLLGDAGTFRERIHLNDRTAISRIRTIQITDFYILLIGSSCLQVIGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6P0</accession>
    <name>A0A1W1I6P0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Blue (Type 1) copper protein, cupredoxin family (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48645">
        <property type="protein sequence ID" value="SLM48645"/>
        <property type="gene ID" value="NSJP_2473"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2473"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012099600" evidence="1">
        <location>
            <begin position="25"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="125" mass="13334" checksum="040737FC869F27AC" modified="2017-06-07" version="1">MLMTLRIFMALAILVLVGAGPTTATAPYTSIIIDSGSPYFVPKSATVSSGSTIRWENPTPTEHTITHTGCMEDGAPCAFDSGLVLPNDSFTIQGLAPGKYPYICRVHPIMYGILTVTDSQQPSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Q8</accession>
    <name>A0A1W1I6Q8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2493"/>
    <dbReference type="EnsemblBacteria" id="SLM48665">
        <property type="protein sequence ID" value="SLM48665"/>
        <property type="gene ID" value="NSJP_2493"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2493"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021383">
        <property type="entry name" value="DUF3015"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11220">
        <property type="entry name" value="DUF3015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="142" mass="15439" checksum="2A2D65FDD3DCC323" modified="2017-06-07" version="1">MAVRRTELLGIAVVACGLFAGACTVTESVKGTLDNITDFTSSTTPGAWSQDGLLRAEHRQIIFATYNYESVKRDIARGEGEHLASLATLLGVAENRSQEFGLLAQARYTEVESPKTSPEEMLTSMRAIVRDHPELVLVADAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I748</accession>
    <name>A0A1W1I748_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase_H_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2663"/>
    <dbReference type="EnsemblBacteria" id="SLM48830">
        <property type="protein sequence ID" value="SLM48830"/>
        <property type="gene ID" value="NSJP_2663"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2663"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="1">
        <location>
            <begin position="88"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="268" mass="30452" checksum="A0D242BCA8291ECB" modified="2017-06-07" version="1">MLTSTFVLLKGVGPGTERRFWQDGIGDWSEFLKRPTVSGISQARKAWYDRDLAEAVSRLEAGRADFFATALKRRDHWRLFETFRHRTLYLDIETTGLPHGLGHVTVVGLYRNGRMSSLVHGDNLTEDRLHDELSQTDLLVTFFGSGFDIPYLQATFPRLDFRKPHFDLCPAARRLGLRGGLKSIEREVQIHRDDDLAGLDGWDAVRLWQHWRAGSESALDLLLKYNAADTQNLEQLAHWVFEGLAARYGPGSVAEIRRSGSMNGIERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7B5</accession>
    <name>A0A1W1I7B5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Anti-FecI sigma factor, FecR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2708"/>
    <dbReference type="EnsemblBacteria" id="SLM48875">
        <property type="protein sequence ID" value="SLM48875"/>
        <property type="gene ID" value="NSJP_2708"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2708"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032623">
        <property type="entry name" value="FecR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16220">
        <property type="entry name" value="DUF4880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4880" evidence="2">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="1">
        <location>
            <begin position="147"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="372" mass="41626" checksum="C1160E514107513B" modified="2017-06-07" version="1">MYLRVEDALFVSSPESYDHLSRMTEQPPTPPPDSVREHAVHWFVRLHSGLATDDDRRAFDAWLAIRQDHRREFEQISRMWTTLDDTQPLLEAEIAKAEDLWKRHDSAPGTTSTWSWWSVRQTAAVGAALSLVLLTTWWWTGLPDTIRYETAKGAQQQVRLADGSTVLLNTDTQLTVQISRSERIITLDRGEAWFTVEHERRPFTVQAGNGSIRDIGTQFLVNKAADAVNVSVWEGSVEVGIRPTGESSSAAAPVILQAGQQTSYGTDGSIAHASAFDRDSLGSWREGTLIFRSQALERVLAEVARYRSEEIRLLHPALASIPVSGVFHIRDLDRFIQTLQDSLPVRAHRVHGTLIVIEPAPVSSNPSVLSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7B9</accession>
    <name>A0A1W1I7B9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48906">
        <property type="protein sequence ID" value="SLM48906"/>
        <property type="gene ID" value="NSJP_2739"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2739"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="79" mass="8730" checksum="9ACDA31A9AD93D87" modified="2017-06-07" version="1">MRLRKVDWLFVVAALAVVIGVSLLPAPRDRNPRIPANGEHQAIVVEKDCVSCHRADGGKPVPARHPKRQDCFRCHARGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7D0</accession>
    <name>A0A1W1I7D0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2743"/>
    <dbReference type="EnsemblBacteria" id="SLM48910">
        <property type="protein sequence ID" value="SLM48910"/>
        <property type="gene ID" value="NSJP_2743"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2743"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="474" mass="52780" checksum="1A70CD291C63A3A0" modified="2017-06-07" version="1">MQCSDDISLARSRNHNFGSGTVCEVAGRRSGFWTTNRNAVLASLANGMRLAVVCLCFPACSHPQLIQNSKLNEYRIHDAIERSSYASGLSVSRPLSVEVVDRHALREIFGRAAIETKQSQIWAAKQDGYSAMGFDIGEAEDPYEHIDLLSRSVGGLYLPRTQTLYVVNEPARSAAGGIYLNAQGDLSHDVTLAHEIIHALQHQHYPGVFEPKEQIWQEQEDAAVALQAATEGDANLWSAQSVGFMGRPRDPDDVIRLSKESEAEPLSDAHFLVRERIMFPYTYGYRFAHHEGRNGMKSPPASTEQVIHIGTSGRSPFEAIDLSSFAEALATRGCRLSFQDTMGELTLSLWLRSFDPTTDQQTWEGWDGDRWIAATCGNSREVAWLTSWDTEQDAVEFARVVSELVGAWRQRARLTSGVRVERMGRDVFVVSDGIRMDVGQVQALAHRARVATRDELLAHFKRTGVNVDRSVQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7E5</accession>
    <name>A0A1W1I7E5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative FAD/FMN-containing dehydrogenase, glycolate oxidase, fused subunits GlcD and GlcF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_2738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2738"/>
    <dbReference type="EnsemblBacteria" id="SLM48905">
        <property type="protein sequence ID" value="SLM48905"/>
        <property type="gene ID" value="NSJP_2738"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2738"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="42"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="522"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="943" mass="103517" checksum="9823347927AD186E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7I7</accession>
    <name>A0A1W1I7I7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48976">
        <property type="protein sequence ID" value="SLM48976"/>
        <property type="gene ID" value="NSJP_2809"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2809"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="99" mass="10813" checksum="BFE209F1549D213C" modified="2017-06-07" version="1">MEVNMISQTVGLKESAPEIQSVEANVLDVLRRRRAKTLDQLEGELVHIGSAQLLFAIDRLSRAGRIGIGPPVKGDYLVWVMPEPAVWAGQAESVSRSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7L8</accession>
    <name>A0A1W1I7L8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2754"/>
    <dbReference type="EnsemblBacteria" id="SLM48921">
        <property type="protein sequence ID" value="SLM48921"/>
        <property type="gene ID" value="NSJP_2754"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2754"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="59"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="148" mass="15717" checksum="BB36F9A734F90594" modified="2017-06-07" version="1">MMITVESTPERPVPGVTILAVLVLALVIPSALFAGSPTSMLIRQDLPDLPGKVATVLTVQYAPGTASDAHQHPGSVFAYVLEGAVVSQLEGEKPVTYTAGQSWYEPPGQAHVVLRNASREETAKILVFILTQEGEELKSPVKLSDVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7S3</accession>
    <name>A0A1W1I7S3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetracycline efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tetA</name>
        <name evidence="7" type="ORF">NSJP_2742</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48909">
        <property type="protein sequence ID" value="SLM48909"/>
        <property type="gene ID" value="NSJP_2742"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2742"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="9"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="404" mass="42916" checksum="928299A28D45562E" modified="2017-06-07" version="1">MTTGARPAAVVFILITVLLDVLSFGVIIPVLPVLVERFMSGDTARAAEIFGLMATAWAFMQFVCSPIQGALSDRFGRRPVVLLSNAGLGLDYVLMALAPDITWLFVGRVLSGMASSSFSTAGAYIADVTGAEQRAAAFGKMGVAFGLGFVLGPAVGGLLGAVDPRLPFWGAAATSLLNACYGYFVLPESLAPEHRRAFSWSRANPIGALVLLRSHRELFGLAIAEFLMSLAHVVLPSVTVLYLGYKFGWDSTAVGLTLAAVGISAMIVQGVLVGPVTRAYGEPRTVRTGLFCGALGFSIYALAPHGWVYCLGIPIMSFWGLAGPAMQSLMTRRVSHMEQGRLQGAIASLIGIAGLIGPSLFTQTFAYFINPAARWHFPGAPFVLASCLLLLAMTIAWRVTRFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7S7</accession>
    <name>A0A1W1I7S7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tmk</name>
        <name evidence="5" type="ORF">NSJP_2941</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2941"/>
    <dbReference type="EnsemblBacteria" id="SLM49108">
        <property type="protein sequence ID" value="SLM49108"/>
        <property type="gene ID" value="NSJP_2941"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2941"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="4">
        <location>
            <begin position="22"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="250" mass="28709" checksum="4747493C4283DC45" modified="2017-06-07" version="1">MTEQTPAPSNAPHPYPGKLIIVEGIDGSGKSTQLLLLHKWLESKGHKVFFTEWNSSELVKDTTKRGKKNKSLTPTTFSLLHATDFASRLYHEILPPLKAGMLVLADRYMYTAFARDVVRGVSPEWVRKLYSFAIRPDMAFYFKVPIEVAISRLLGGTRGQFKYYEAGMDMNLSQDVTESFRIFQSRILSQYDKIVDEYQLITMDATKDIAAQQDGMRSLVDEALKDYKPRRGTHGRRSLFWRRFDVPKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I831</accession>
    <name>A0A1W1I831_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49160">
        <property type="protein sequence ID" value="SLM49160"/>
        <property type="gene ID" value="NSJP_2993"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2993"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012325568" evidence="2">
        <location>
            <begin position="27"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="248" mass="27179" checksum="4D4C54E427CD405C" modified="2017-06-07" version="1">MKTLRNLPACHAALLTLLLLSSSACSRWIELTDDDASLQRRDTTRTITQQEQVPLLLDRVQLIRNGSPQNPSQDTDRRLLGSLREIGLFSRSDSSEHVGAPTQGKTIRARLVIDEAVDPHSGAAAWKGIVIGASMFLLTPVIPLEYDYASHMTLELERWDGQIKRYEGRSAGTSRYHLFGASPLVIDELKGVVTESCLTALMEQLVQDSSFYTASSAPLPDNPIRSVSVKPRPSGSAPVVPVFTPSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I888</accession>
    <name>A0A1W1I888_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative large multi-functional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3049"/>
    <dbReference type="EnsemblBacteria" id="SLM49216">
        <property type="protein sequence ID" value="SLM49216"/>
        <property type="gene ID" value="NSJP_3049"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3049"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010700576" evidence="1">
        <location>
            <begin position="24"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="2">
        <location>
            <begin position="150"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="328" mass="36084" checksum="665B78A1079ACE7D" modified="2017-06-07" version="1">MRTWWEKAFVLCLLLVAPTCGRAQERPGVFTDPAHAGPDFGIQGEYLGDVSVESNLLHWGAQVTALGQKRFHLTLFSGGLPGQGWQPGDRKMEADGTSGEDGTRFQVESWHASITQGLLTLSGPDQSQLGTLKRIERKSSTLGSTPPPGAIVLFDGRTAEAFTNGKIVMQDLLAADVASRRTFGDHRLHVEFRVPFKPEARGQGRGNSGVYLQNRYELQILDSFGFETGYDACGGIYSIAAPSINMSFPPLTWQTYDIDFTAARFNHEGKKQRNARVTIRHNAVVIHENLELPHGTPGRAAEGPLPDVLYLQGHGDPVVFRHIWILPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8C8</accession>
    <name>A0A1W1I8C8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49298">
        <property type="protein sequence ID" value="SLM49298"/>
        <property type="gene ID" value="NSJP_3131"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3131"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="151" mass="17147" checksum="5116A4703CDAEC9F" modified="2017-06-07" version="1">MAQETFLTENMSSSSSHDSEPVSFIRQRPVRIAIYAGLTLFALLMVVWPLIVQIRDPSFQNHIAEHRVMVGMSKEQVLQSWGGPQTINTTFTKDGIRQEEWIFEDWESTAVVKHRYLYFEEGTLIGGWFQGSGERLPAQGPSNPHIPKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8H7</accession>
    <name>A0A1W1I8H7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3128"/>
    <dbReference type="EnsemblBacteria" id="SLM49295">
        <property type="protein sequence ID" value="SLM49295"/>
        <property type="gene ID" value="NSJP_3128"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3128"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039068">
        <property type="entry name" value="PqqC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40279">
        <property type="entry name" value="PTHR40279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="251" mass="28709" checksum="A1145779D1BE9848" modified="2017-06-07" version="1">MVKRMTKARFQEEILRIMDRKDHWAWPFFAKGAVPVDRLKRHFQQEYEVYVRDFPVLLARIHGHNPPPGVRRMLAENIYEEDTGGLSLGKSHPDLFLSMMSGLGYMERDFEDVRLLPAAKQYRAWLERASDNRAWLVGAAAMTVFVEGSVKDRKELAEPSKPKTAEEVESVIGEHALVKHYGLSPDCMDLIRAHQMVEAGHRHDAYDMVVNYAVTSAQQRAILSCLKKCLTLWHAYRDAVARACGLTKARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8I1</accession>
    <name>A0A1W1I8I1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49103">
        <property type="protein sequence ID" value="SLM49103"/>
        <property type="gene ID" value="NSJP_2936"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2936"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="28" mass="3238" checksum="D18FE4F13E8119D6" modified="2017-06-07" version="1">MDFAVILILSNTLMAVLIYIVITKIWQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8I7</accession>
    <name>A0A1W1I8I7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease PH</fullName>
            <shortName evidence="4">RNase PH</shortName>
            <ecNumber evidence="4">2.7.7.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rph</name>
        <name evidence="7" type="ORF">NSJP_3138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)</text>
            <dbReference type="Rhea" id="RHEA:10628"/>
            <dbReference type="Rhea" id="RHEA-COMP:17343"/>
            <dbReference type="Rhea" id="RHEA-COMP:17344"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:173114"/>
            <dbReference type="EC" id="2.7.7.56"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexameric ring arranged as a trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.56" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3138"/>
    <dbReference type="EnsemblBacteria" id="SLM49305">
        <property type="protein sequence ID" value="SLM49305"/>
        <property type="gene ID" value="NSJP_3138"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3138"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009022">
        <property type="term" value="F:tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11362">
        <property type="entry name" value="RNase_PH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00564">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002381">
        <property type="entry name" value="RNase_PH_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018336">
        <property type="entry name" value="RNase_PH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01966">
        <property type="entry name" value="RNasePH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01277">
        <property type="entry name" value="RIBONUCLEASE_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="RNase_PH" evidence="5">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="6">
        <location>
            <begin position="166"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate (substrate) binding" evidence="4">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="247" mass="26773" checksum="0FDED0FF955CCD46" modified="2017-06-07" version="1">MNGSGGMLRADGRRKDQLRPIKITRNFIKHAEGSVLIEMGDTKVICTASVEEKVPPFLKGKGTGWVTAEYSMLPRSTHDRSPREAVKGKQGGRTLEIQRLVGRALRAVTGMDQMGERSIWIDCDVIQADGGTRTASITGAFIALADAFTTLKTRGLIKKRPLTDYLAAVSVGKVGGEILVDLAYVEDSAAEVDMNLVMTSKGQFVEIQGTAERTPFAKQDMDGFLAQGWSAIQTLTNLQRDLVGALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8I9</accession>
    <name>A0A1W1I8I9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3170"/>
    <dbReference type="EnsemblBacteria" id="SLM49337">
        <property type="protein sequence ID" value="SLM49337"/>
        <property type="gene ID" value="NSJP_3170"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3170"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="191" mass="21742" checksum="13130584C05CF0C4" modified="2017-06-07" version="1">MTHLRSFVLYSDFNCPFCYALHERLHRMKLLESVDWRGVQHAPYLPRPMRQWDGTMKAELQYEVPAVRRLDPDLLIELPKGKPNTARAIDWAARLLSSDIHGGMEFVRLVYAAFWRDGLDISDEAVLDQLAAQHTDTGIPGRAEERSGSIAREWEEGWHGTGQSSVPILVSPDDRLLVGCVPSEQIVRFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8K2</accession>
    <name>A0A1W1I8K2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49320">
        <property type="protein sequence ID" value="SLM49320"/>
        <property type="gene ID" value="NSJP_3153"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3153"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="23" mass="2638" checksum="3F05714064E2A93F" modified="2017-06-07" version="1">MSSKFGFFRSNLTHLVFALPLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8M9</accession>
    <name>A0A1W1I8M9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3199"/>
    <dbReference type="EnsemblBacteria" id="SLM49366">
        <property type="protein sequence ID" value="SLM49366"/>
        <property type="gene ID" value="NSJP_3199"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3199"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="171"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="217" mass="23833" checksum="D8E950EE67019242" modified="2017-06-07" version="1">MKEEQRVNTVIATSGVKAMILICGGFILSGCVLSEKYEAEKARSLNFQRLLSQEEKRTAELDNEVKRSKKELAEYEARNRELTAQVQAVREQMGRVQEEADAIKEAALLERKARADMKRIPPAPKVHAAPPVEATPGMGELSASSMSGLPEEAAASAAQMETAAAAGHGPTIHVVKPGETLYRISRRYGVKLETLRKWNKLPDDIIEVGQKLIVGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8N5</accession>
    <name>A0A1W1I8N5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3241"/>
    <dbReference type="EnsemblBacteria" id="SLM49408">
        <property type="protein sequence ID" value="SLM49408"/>
        <property type="gene ID" value="NSJP_3241"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3241"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="217"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="324" mass="35329" checksum="92F4E6B8443B70BD" modified="2017-06-07" version="1">MQQALDFLLHHIELVVFLTVLAEQVGLPVPGIPLLLAAGAVAGEGQANLAVLTCISVAACLLGDMVWYELGLHRGRQALSLLCRISLEPDACVRRTENFFVAHGVRALVLAKFIPGLSTLAPALAGLFKVSLGRFFLFNGAGSLLWSLSFLLLGYVFSDQIGYVADLAVRFGTTAGIIIAVSLAGYVVFKYFNRQKLLRELRVARITPAELKQLLDDGQQSVIVDLRGNVDHVADPYTIPGALRISAEELEHRHHDIPRDRDIILFCACPNEATAARMALMLKRRGISRVRPLLGGIDVWRELAYPLELVIAKENAVGTSKISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8R0</accession>
    <name>A0A1W1I8R0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">prfB</name>
        <name evidence="6" type="ORF">NSJP_3213</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3213"/>
    <dbReference type="EnsemblBacteria" id="SLM49380">
        <property type="protein sequence ID" value="SLM49380"/>
        <property type="gene ID" value="NSJP_3213"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3213"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="5">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="374" mass="41608" checksum="ED0AB0A6982B43EE" modified="2017-06-07" version="1">MCACVRSVSRCLNSGGIFDFARMTSELDELERQIAQPNFWSNAQAAAKVSRKKATLEHDLQEWREIEQTLKDLGALLELAEESGDAGLEAELTVELDRFEPRLAILRVEMLLSGELDSNNAILSIHPGAGGTESQDWAQMLLRMYVRWAEGKKFKVETLDLQSGDEAGIKSATVSITGPYAYGYMKAEAGVHRLVRISPFDSNKRRHTSFASVFVYPELNDDIDVVVEDKDLRIDTFRAGGAGGQNVNKVETAIRITHLPTGIVVQCQNERSQLQNRNGAMKILKARLFEVEQKKKEAEFNAIVGEKKDIAWGSQIRSYVFQPYQMVKDHRTGYEVGQVSAVMDGDVDGFIEAYLKKKLTGGLLAPAKTAADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8X1</accession>
    <name>A0A1W1I8X1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-demethylubiquinone-9 3-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3268"/>
    <dbReference type="EnsemblBacteria" id="SLM49435">
        <property type="protein sequence ID" value="SLM49435"/>
        <property type="gene ID" value="NSJP_3268"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3268"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009725">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021700">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="159" mass="18494" checksum="D74A1F908809EA8A" modified="2017-06-07" version="1">MPKMYICLWSNDKAEDMANFYKSVFKGTKIGKTWYWGPNPMRVKEGSVLTMDITVLGQRIMLLNGFSKMPFNESVSMVVPCKNQREIDAYWKALLRGGGKPVQCGWLIDKFGVRWQVFPVEIEKWQASKNKKKKQAMNEAMWKMVKLDAKKLKEAFDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I936</accession>
    <name>A0A1W1I936_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49510">
        <property type="protein sequence ID" value="SLM49510"/>
        <property type="gene ID" value="NSJP_3343"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3343"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="122" mass="12779" checksum="FB6F9AD38006E559" modified="2017-06-07" version="1">MQEGTAGTIDTDRTESTSWTDSVAPGGNSVLRTVEDGVNSAGHATWEFFHHLPGHGAVIGGAMGLGAAMVVGVAELATACFAGYVSYRIFAYGESLCEAIENAIKFESGKLDKEEIDKPIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I957</accession>
    <name>A0A1W1I957_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="8">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">IMP cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">purH</name>
        <name evidence="10" type="ORF">NSJP_3377</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="8"/>
    <dbReference type="EC" id="3.5.4.10" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3377"/>
    <dbReference type="EnsemblBacteria" id="SLM49544">
        <property type="protein sequence ID" value="SLM49544"/>
        <property type="gene ID" value="NSJP_3377"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3377"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM49544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="517" mass="55662" checksum="CE2D5282B546D445" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I988</accession>
    <name>A0A1W1I988_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxidoreductase, molybdopterin binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_3282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3282"/>
    <dbReference type="EnsemblBacteria" id="SLM49449">
        <property type="protein sequence ID" value="SLM49449"/>
        <property type="gene ID" value="NSJP_3282"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3282"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030835">
        <property type="entry name" value="Sulfite_DH_SoxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04555">
        <property type="entry name" value="sulfite_DH_soxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013026315" evidence="5">
        <location>
            <begin position="36"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_molyb" evidence="6">
        <location>
            <begin position="110"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Mo-co_dimer" evidence="7">
        <location>
            <begin position="297"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="423" mass="46629" checksum="44AAE64C0B4F29C5" modified="2017-06-07" version="1">MNDETEGVNRRKFLRRSASLIAGGAAALAVPAARAEPSDSPKDPMRVPGALPRPYGDRSPFETAQRSGAGGPGSAHGWGSNAPNNINSTTPLQDLHGIVTPSALHFERHHNGVPAIDPARHRLLIHGLVDRPMVFTLTDLERISSVSRLAFLECSGNSWDCWAEKAPDFTVQELHGLTSTSEWTGVKLSTLLDIVGVQRGAGWMLAEGSDASGLDRSVPLTGDVLEEAMICYGQNGEALRPEQGYPMRLLLPGYEGNINVKWLRRLKFGTAPFMTRWETAKYTDLMPDGTAYQFSLVMEAKSVITSLSGRQQIQPGFHEIRGLAWSGRGRVTKAEVSLDGGRTWQAAQLQEPILPKCHTRFRLPWKWDGQEAILQSRCTDETGYVQPTRQDLVNVRGTNSVYHYNGIQSWKVERDGHVRNISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I993</accession>
    <name>A0A1W1I993_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Formate hydrogenlyase, membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3393</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3393"/>
    <dbReference type="EnsemblBacteria" id="SLM49560">
        <property type="protein sequence ID" value="SLM49560"/>
        <property type="gene ID" value="NSJP_3393"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3393"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038730">
        <property type="entry name" value="HyfE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38601">
        <property type="entry name" value="PTHR38601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="222" mass="24025" checksum="CD0F45E56A30F669" modified="2017-06-07" version="1">MSWLTPHVGAQLVDLGSAMLLLTCFAIVAQRRLSACVDLFALQSFFLAMTAALVAFLTGTRHIYVAAALTVAVKGLVIPHVLRRVIERLNVTRELVMNVNVPASLLICGALVMLAFFITQPIISFGHLLTRNSLAIALAIVLIGFFTMIARQKAVTQLIAFLVMENGLFLGATAATYGMPLIVELGVFFDVLVAALIAGIYTNRLQDAFDSVDTSRLSELKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9I1</accession>
    <name>A0A1W1I9I1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49650">
        <property type="protein sequence ID" value="SLM49650"/>
        <property type="gene ID" value="NSJP_3483"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3483"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="299" mass="34403" checksum="2B19905C42B0B1F2" modified="2017-06-07" version="1">MAHELTTLLERDGLVRLPVIIPPAQLLSMQQAFETRLQRMSWNDVPGFERTEKFRHMIQDVLTLDQGFVDVSLHPLVKQILYEYIGPGTQLVEAKGWLSLPTKTDFHGWHGDAWYDQQMNSDIPREIKLAVYLTDVSSGAFSYIKGSHRQQHPRLVPDRELAGIAADRIVQVTGPAGSAFLFDTSGIHRQATPVLESRQAVFLNYHDPAIALQREDIEYYRYHPLVLNAAFLGNLTQEDQRMLGFGDKRNYQHGFVRKRRHPALEIMNRSLVEAVMEMNHMMHYPRRIVAKMRSVMGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Y9</accession>
    <name>A0A1W1I9Y9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized ferredoxin-like protein HI_0527</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_3635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3635"/>
    <dbReference type="EnsemblBacteria" id="SLM49802">
        <property type="protein sequence ID" value="SLM49802"/>
        <property type="gene ID" value="NSJP_3635"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3635"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="115" mass="12332" checksum="A22B7CB5BBB2A78E" modified="2017-06-07" version="1">MALLITAECINCGACLPECPNEAIFENRSDAEAKGHHVGDDQGVGDGIYVITHDRCTECVGHFDEPQCAAVCPVDNCCISDPAYPETTDVLLEKAKTLNPDKAIDPAKVWSGVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA46</accession>
    <name>A0A1W1IA46_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Excisionase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49917">
        <property type="protein sequence ID" value="SLM49917"/>
        <property type="gene ID" value="NSJP_3750"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3750"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="3"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="88" mass="10291" checksum="1DA4359CD1CE238F" modified="2017-06-07" version="1">MTLMTISEAARFLRLSKRTLYQRTDIPRIRYGHRIMFVKEDLEAWIGVLRDGCVTREIAETGRQQSTVDPISPKVYHRNPLFISPSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAE1</accession>
    <name>A0A1W1IAE1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3672"/>
    <dbReference type="EnsemblBacteria" id="SLM49839">
        <property type="protein sequence ID" value="SLM49839"/>
        <property type="gene ID" value="NSJP_3672"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3672"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="95" mass="11077" checksum="98D1627FDE42A316" modified="2017-06-07" version="1">MKKSRMQKRKSPSQLIDERIKELGDWRGTMLSRLRVLIKQADPQVVEEWKWRGVPVWSHEGMICTGERYKIPPASSMPVLRETPGVPSTFTRVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAE5</accession>
    <name>A0A1W1IAE5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49976">
        <property type="protein sequence ID" value="SLM49976"/>
        <property type="gene ID" value="NSJP_3809"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3809"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="56"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="263" mass="30213" checksum="96CFCF8E1AB16648" modified="2017-06-07" version="1">MTYETAYDARVKEVLNSNETYYRMMVEWHASHDGLAVEADVKRIIESACRPGHLVLEAGSGPGCITNWFARRHPETRFFGADISHIAVDLARAAAPQNAEYHVADLKRIPFEDHSFDFIFSQSVLEHIVGWEYALRELYRVLRPGGQLLIRVENGGIKQARSRTYALMNYVFLRNRVTIEEPSFRLDPGDWTQHEMNFDVQEIPSDVLLSTLRRNGYAISWFTTGTKSWRGCGNWKAEVVSYLQFWPFNHLGSTTIVLAEKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAS2</accession>
    <name>A0A1W1IAS2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative tonB-dependent receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_3929</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50096">
        <property type="protein sequence ID" value="SLM50096"/>
        <property type="gene ID" value="NSJP_3929"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3929"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030149">
        <property type="entry name" value="FcuA/FatA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010917">
        <property type="entry name" value="TonB_rcpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF82">
        <property type="entry name" value="PTHR32552:SF82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01156">
        <property type="entry name" value="TONB_DEPENDENT_REC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="STN" evidence="7">
        <location>
            <begin position="83"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM50096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="860" mass="92928" checksum="8ECA208B281577CB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAU5</accession>
    <name>A0A1W1IAU5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate kinase</fullName>
            <ecNumber evidence="2">2.7.2.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.2.4" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50120">
        <property type="protein sequence ID" value="SLM50120"/>
        <property type="gene ID" value="NSJP_3953"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3953"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005625">
        <property type="entry name" value="PepSY-ass_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34219">
        <property type="entry name" value="PTHR34219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03929">
        <property type="entry name" value="PepSY_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="513" mass="58407" checksum="5851A2019B53D879" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAY7</accession>
    <name>A0A1W1IAY7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4149 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3993</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50160">
        <property type="protein sequence ID" value="SLM50160"/>
        <property type="gene ID" value="NSJP_3993"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3993"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="DUF4149"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4149" evidence="5">
        <location>
            <begin position="30"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM50160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="185" mass="20095" checksum="BBF47B1EC2E3587F" modified="2017-06-07" version="1">MSCRGLHQPVDTVNRWVYRGLLCGLTLELLALATWVGGLIVLIGAVIPAVFNTLGGQDSGGFLLTRAFEGYNRLVVVAMALLVAIAVCRQWSGHPAVSVSRLEVVLLTLMGILLCVIVLVLHPQAAALQAEAFAVKDEQARKAAFEAFFRLHMPVRSLYMINMGLGIALLAMKVTRLVSRRESQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB13</accession>
    <name>A0A1W1IB13_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Magnesium transporter MgtE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mgtE</name>
        <name evidence="10" type="ORF">NSJP_4080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4080"/>
    <dbReference type="EnsemblBacteria" id="SLM50247">
        <property type="protein sequence ID" value="SLM50247"/>
        <property type="gene ID" value="NSJP_4080"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4080"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00400">
        <property type="entry name" value="mgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="175"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="238"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM50247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="486" mass="53279" checksum="A0B0F4F36CB0348B" modified="2017-06-07" version="1">MHQTDKLTESRQTESRHRVGDRDLLRDALRDQADRGQTKSDIVLLSVQRLLRRGAITNLAKMLGRMHPADVAKVIVHLSSPKEKREVFELVRGDSKRGQVLSELDTDSITQVLADLLQSDIAWLIKDLGPDDVAYILGVLPEERAKEILSLMRTEDSTEVADILKYPKDTAGGIMTTEFFALSEDATAQDAIRRLQEATDAEMVFYIYVTAKDERLVGVLSLRQLLTVPPSTPLKNIATRDVISVSVDMDQEEVARQVASYNLLAIPVVDKEGILVGIITVDDVVDVIREEATEDMLKMAGAVQEEAVSKSSSLSAAKVRLPWLFTNLVGSLLSGAILWEFRYTIQDVVAIVSFIPVIAAMGGNVGLQSSTLIIRGLATGVVELTDVWSVFVREVKIGLLMGVACGMILSLVGWIWHQGFLGMVVGVSLITAFLVSTSMATFMPIFLKRMGVDPAVAAGPFVTTANDITGITIYLTLATVFMEYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB19</accession>
    <name>A0A1W1IB19_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_4029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4029"/>
    <dbReference type="EnsemblBacteria" id="SLM50196">
        <property type="protein sequence ID" value="SLM50196"/>
        <property type="gene ID" value="NSJP_4029"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4029"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="130"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="412" mass="45756" checksum="36C5E67528787CC9" modified="2017-06-07" version="1">METSIASSIGSKGCVLVTDGDERSALAVTRGLGQAGIPVVVGAETDSSLAGASRYCVSRWRYPSPLTNPMQFISSLAEAIRQLNISAVMPVTDASMQAVTEYRERLGLSKTHGLPSWESYNSVSDKYGLCHLAVELGVPIPSTIFVEQGVPPADTEVLGDYPLIVKPRRSLMSVNGHWARTSVHRVGSREELNQLYRTVPYLREPSLIQKCIEGEGQGVFALCNAGDPVALFAHRRLREKPPSGGVSVLRESIALPKEMTDHAVRLLKKVGWHGVAMVEFKVEHGTGIPNLMEINGRFWGSLQLALDAGLNLPNLLYRLAVQHPVAMPASTYRTGVRSRWLLGDLDHLLMRTFKSDEALRLPSGYPSRLRSTTEFVHFWQKDLYYEIERWDDLGPARYELQKYIRHLVKGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBJ7</accession>
    <name>A0A1W1IBJ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="13">2.7.8.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pgsA</name>
        <name evidence="13" type="ORF">NSJP_3976</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="13"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3976"/>
    <dbReference type="EnsemblBacteria" id="SLM50143">
        <property type="protein sequence ID" value="SLM50143"/>
        <property type="gene ID" value="NSJP_3976"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3976"/>
    <dbReference type="UniPathway" id="UPA00263">
        <property type="reaction ID" value="UER00377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM50143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="198" mass="21463" checksum="2FDE109882AE7CB9" modified="2017-06-07" version="1">MNRVLEMWRSVGQESLNLPNVITLFRILLIPVFVILFITPTEDRSLSAAVIFVVAAMTDLLDGYVARRTGQITRLGKLLDPIADKLLVLSALILLVNVDRVSALVAILVIAREVAVTGIRAIAAGEGMIISAETTGKYKMALQVVAITMLILEGTEVSEWGNLHLAGIVTLYLSLVLGYVSGGQYVLSFWKQIVAKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBP1</accession>
    <name>A0A1W1IBP1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_4154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4154"/>
    <dbReference type="EnsemblBacteria" id="SLM50321">
        <property type="protein sequence ID" value="SLM50321"/>
        <property type="gene ID" value="NSJP_4154"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4154"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="319" mass="37725" checksum="26ACCE26302495A5" modified="2017-06-07" version="1">MMTVSAEQTRPVNPHFDHDRIVWRDEYSGQYQPVEYGEQFDDQWRLFLERRVGFCRHTGVETSDPYVDDRIFELTGVKDLLARRRYGLWLPMVRRLGRGRRDEQRREVGGRLHLHPKFPVDHFQGKRCLDIGCGAGRWTRALMALGATVKSVDVSRHAVRSTRRFNDDVESLNLFDILERRPDLHGAFDFTLCWGVMMCTHDPKLAFMNVARTVRPGGELYAMVYAPTYHNSPFVLESRRYYHRQLASIEERLRYAYEIADRPENAINLFDMLNTFFNWTIEEDLIREWYLAEGFTDVVMLNRDEPHKCAYHMLGKKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZN2</accession>
    <name>A0A1W1HZN2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46177">
        <property type="protein sequence ID" value="SLM46177"/>
        <property type="gene ID" value="NSJP_0005"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0005"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="281" mass="32618" checksum="E3C84BA45796C288" modified="2017-06-07" version="1">MKVSGFTFCRNAVKYDYPVVESIRSVLPICDEFVVNVGRCDDGTLELIRSIGDPKIKIVESVWDEMLRKDGLIYSQQTNIALARCKGDWALYMQADEVMHEDDLGALQDSMRRELGNTAVKGLLFRYLHFVADYWSTNPWFYHKAVRVIRNNGEVESCGDAVGFHFKPTQQYLQSGPKEWLAWSGARIFHYGWVKDPKVMLAKVKEQISRHHGDTPPADQAGLYRQEAFQFDDYAVLKEFSGRHPAVMQERIRGAARWAERRSRWLNPRFYREVLKRGFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZV8</accession>
    <name>A0A1W1HZV8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0109"/>
    <dbReference type="EnsemblBacteria" id="SLM46281">
        <property type="protein sequence ID" value="SLM46281"/>
        <property type="gene ID" value="NSJP_0109"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0109"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="269" mass="30890" checksum="7A391D3EF9667E52" modified="2017-06-07" version="1">MSDDTSVPVEQSRAAVDPNDQPLNPDEEIAEIEKLLAAEPDDFQARCRLGELYFSKGRLDDALVEVKKSIEMAEGLRAEMNRSLAMYYSNLGTIYATKNMSDEAETEFKHALDVFQYDVLALFNLGRVYADKKKYMEAKGYYERLVEITPDDPIAWYNIAGVYVDLDNPQVSDYNTIDMAIQCYLRTLELDPKHLEASFKLMELALNHKKSDLAIKVMEDAVEQNPDEPLAYYNLISVYDKCKMFEQAEQARQRLKERFAKRSKESSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I003</accession>
    <name>A0A1W1I003_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">argS</name>
        <name evidence="13" type="ORF">NSJP_0125</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0125"/>
    <dbReference type="EnsemblBacteria" id="SLM46297">
        <property type="protein sequence ID" value="SLM46297"/>
        <property type="gene ID" value="NSJP_0125"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0125"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="8"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="438"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM46297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="583" mass="65329" checksum="64823D78932FF1DA" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I034</accession>
    <name>A0A1W1I034_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46327">
        <property type="protein sequence ID" value="SLM46327"/>
        <property type="gene ID" value="NSJP_0154"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0154"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="43" mass="4962" checksum="94C10E48699477C4" modified="2017-06-07" version="1">MGPPRYADLEYEYVDVRLEDPLEPACADGGLDFREDMSDLKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I044</accession>
    <name>A0A1W1I044_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46366">
        <property type="protein sequence ID" value="SLM46366"/>
        <property type="gene ID" value="NSJP_0194"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0194"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="104" mass="11368" checksum="92A41A4D4B5B2522" modified="2017-06-07" version="1">MAGDPPGEGSTRDFGPTDVMASEEVRLEEVSNDQKYSVHPLIGRRRLVYRSCGRGLVEILRAGQDCRREGAPVRSRTGRPVAGGRKGDSDLRRSDRSLVDSGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I062</accession>
    <name>A0A1W1I062_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_0185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0185"/>
    <dbReference type="EnsemblBacteria" id="SLM46357">
        <property type="protein sequence ID" value="SLM46357"/>
        <property type="gene ID" value="NSJP_0185"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0185"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="368" mass="39691" checksum="02B078C77E2CA3D9" modified="2017-06-07" version="1">MSAQAHVHPVQWFDAEEQDKLFLKLKRALAASFVLHVVLLLVVAGLRLPQHGERPLSSMEVSLVSVPAPVQQVEASKPVVQPKPSEPRRAPAPPVKQVAPAPVPVPPAPRASVAPNPAPPAPAVPVSPIPAPTPPAPVAAPVRQSIAKDILRDLQLPPDAPKLGELTPAKAVAQPQPQAPIPKVKLPDLPRIPDTMPDRVVKAHQQTPQTSLSEDQNRELEEELKKVKHFQPAAKLETPKEVPVKVTPPPQEASVPVAKVAPQTMLKASGASGTNPFWARVEAIIKSNWEPPPVDATGSTYSVVVKFRFYRNGTVKDIGIEHSSGNDYFDMAGQRAVQKPRAFPPFPSEMTEAYQDVEMVFRVGEALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0D4</accession>
    <name>A0A1W1I0D4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_0272</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46444">
        <property type="protein sequence ID" value="SLM46444"/>
        <property type="gene ID" value="NSJP_0272"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0272"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="33"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="163" mass="16794" checksum="5E387BACC1164737" modified="2017-06-07" version="1">MSDRTVSALIVAVIGLGLIWTLFVRAPLPAPSTSGDSGQAALSPGTVPLVTGEEPVEVILTRAGCPVCHTIPGVTGANGKVGPPLILGRTGEARLKDPSYHGSATTIAEYIAESIMDPGAFVVSGYPSATMPTWYGTKLSALALEKIVSYLERQTEESGVSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0G1</accession>
    <name>A0A1W1I0G1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46457">
        <property type="protein sequence ID" value="SLM46457"/>
        <property type="gene ID" value="NSJP_0285"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0285"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="57" mass="6671" checksum="11F0F1D335A177D8" modified="2017-06-07" version="1">MESLTAMVLYLTCFTLLSVRKHFLGNVWKDGQEPQQKQVGEERRNYLDIVRGRAGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0J9</accession>
    <name>A0A1W1I0J9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase, type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0237"/>
    <dbReference type="EnsemblBacteria" id="SLM46409">
        <property type="protein sequence ID" value="SLM46409"/>
        <property type="gene ID" value="NSJP_0237"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0237"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="36"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="295" mass="32853" checksum="48FEE1A69155B24F" modified="2017-06-07" version="1">MVLVNIGCGSTWHPAWINLDVRPSHGQVKRWDALLGLPFADAEVDACYSSHFLEHLSRTQARALMVEAGRVLKPGGIIRLAVPDLEAMTKEYLSLLTQAASGDETAARRYEWITLEMLDQLVRTESGGEMERYLRSQAGGNADYVLSRIGPGAKEYLCQSKTVDNPRPSDDRNVAGPPHAGLQRALCAAVAPLKRIFQRTGHSFQDVAAQWCGALAGARGRQAMQEGLFRQSGEIHRWMYDRFSLRRLLEQAGFQQIHTRTAFESRIPAFATFGLDVLDGRVRKPDSLFMEAVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I128</accession>
    <name>A0A1W1I128_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tryptophanase</fullName>
            <ecNumber evidence="6">4.1.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tnaA</name>
        <name evidence="6" type="ORF">NSJP_0536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-eliminating lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.1" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0536"/>
    <dbReference type="EnsemblBacteria" id="SLM46708">
        <property type="protein sequence ID" value="SLM46708"/>
        <property type="gene ID" value="NSJP_0536"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0536"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009034">
        <property type="term" value="F:tryptophanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011166">
        <property type="entry name" value="Beta-eliminating_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018176">
        <property type="entry name" value="Tryptophanase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001386">
        <property type="entry name" value="Trpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00853">
        <property type="entry name" value="BETA_ELIM_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="5">
        <location>
            <begin position="46"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR611166-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="468" mass="52732" checksum="614FC766FACFB706" modified="2017-06-07" version="1">MKFPSEPFKIKVVEPIRRTTREERDRLLRGAGYNLFQVPAESVYVDLLTDSGTSAMSDDQWAGLMLGDESYAGSRNYYHFEQAVRSIFGYTHVIPTHQGRMAENLLFSTVVKPGACVPNNIHFDTTRANVEHQGAEALDVVIKEAYDPHCEMPFKGNMDVVRLEETINRIGPDRIPLVMLTITNNSGGGQPVSMDNVRRTRVLLDRYRIPLFFDACRFAENCFFIKEREPEFVSTPILDIARELFSYGDGCTMSAKKDGLVNIGGFLSLNDDRWAQDITNMLILVEGFPTYGGLAGRDLEAMARGLREVLDEDYLAFRIGQVRYLGELLDQAGVPILKPIGGHAVYLNAKEFLPHIPRAQFPAQSLVAALYREYGIRGVEIGTVMFGKTDPATGRTAYPELEMVRLAIPRRVYTNMQITYVAESIIELFRRRETTCGLRLTYEAPVLCHFTARFEEVLQSSPVAQPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I144</accession>
    <name>A0A1W1I144_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0235 protein NSJP_0417</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0417"/>
    <dbReference type="EnsemblBacteria" id="SLM46589">
        <property type="protein sequence ID" value="SLM46589"/>
        <property type="gene ID" value="NSJP_0417"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0417"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="PTHR13420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="SSF69786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="101" mass="10970" checksum="1C8598963101F3FF" modified="2017-06-07" version="1">MTTSLLCDGKDGTVLTIHLQPKSSRTAWVGKRGDALKVRVAAAPVDGEANDALIAFLAGEFDVAARAISIESGFTGRRKRLLIRGVSARQLEARLSRYGWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I175</accession>
    <name>A0A1W1I175_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46734">
        <property type="protein sequence ID" value="SLM46734"/>
        <property type="gene ID" value="NSJP_0562"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0562"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="178" mass="19812" checksum="4904119CF6F06A74" modified="2017-06-07" version="1">MKDWPNTDPMELDSLRRIIEEPKPEQGLELHVGSNVFRTTNGVVKIQGKEHLVLEVRPDPPGLFLTMDIYDEQGRRIGHLRRNSVSASSAERFAVSSSAAPNLTINDALNVMVVDRETGRTLIEAYLFQKRKIRIASGQFYSHKGEFVSISPHYCRVGTGFARFGDVIESRGGTAAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1A3</accession>
    <name>A0A1W1I1A3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0614"/>
    <dbReference type="EnsemblBacteria" id="SLM46786">
        <property type="protein sequence ID" value="SLM46786"/>
        <property type="gene ID" value="NSJP_0614"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0614"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012370784" description="Ysc84 domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Ysc84" evidence="2">
        <location>
            <begin position="103"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="189" mass="19854" checksum="1CEA77E8B8CE5479" modified="2017-06-07" version="1">MRGSISRDLQLVAMVAGSALLLNAWLAGPASAASAKEIDAGADEAIVKFEQEVKGGKAFIESSKGMLVFPKVIKGGAGFGGEYGEGAFRVKGKTVDYYSMLQGSFGLQLGGEVKTVYLVFLDEAAMKKFHDGEGWKAGVDGSVSLVTLGAGGTIDTNNMKDPIVAFVLGQKGLMYNLSLEGTKFTKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1J9</accession>
    <name>A0A1W1I1J9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46703">
        <property type="protein sequence ID" value="SLM46703"/>
        <property type="gene ID" value="NSJP_0531"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0531"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="93" mass="10134" checksum="0144AFD5B7CFB6E3" modified="2017-06-07" version="1">MSITQSFWSVPHRDSEPPFWVCMSCLSEVFYRKVPMPDCPSCHGVSTYEAFSLEAIRDWGTEDLISKAVAGEQAAVPAATTEAASTSSIESTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1M8</accession>
    <name>A0A1W1I1M8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0597"/>
    <dbReference type="EnsemblBacteria" id="SLM46769">
        <property type="protein sequence ID" value="SLM46769"/>
        <property type="gene ID" value="NSJP_0597"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0597"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="35"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="100" mass="11189" checksum="6972018E11D92346" modified="2017-06-07" version="1">MDRVEVRQSASTLPGSSLLIIGSYTATILFMQTQLKSWREKRGLSVRSLAERSGVHYVSIVKLENGRLDPQLSTVIKLCQALRITLNQLVGPLQRPQKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1N0</accession>
    <name>A0A1W1I1N0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ybeY</name>
        <name evidence="8" type="ORF">NSJP_0722</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0722"/>
    <dbReference type="EnsemblBacteria" id="SLM46894">
        <property type="protein sequence ID" value="SLM46894"/>
        <property type="gene ID" value="NSJP_0722"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0722"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="159" mass="18142" checksum="2AECCE5F8E7106BA" modified="2017-06-07" version="1">MSVFVEIRTRIPKVNPVSVVKFALAILSAVGEQDSDMSVTFVGDQRMRRLNRQYRHKDRTTDVLAFAFRDAHLPIRMRMNASPLGDVVIAMPTAIRQARAASRSLGEEMAVLLIHGILHLCGYDHEASEKEARRMRWRERILLQQVGVFPSFIKLASKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1T5</accession>
    <name>A0A1W1I1T5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-alanine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-amino acid aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">D-amino acid transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">D-aspartate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dat</name>
        <name evidence="8" type="ORF">NSJP_0769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + D-alanine = D-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:15869"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="EC" id="2.6.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.21" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0769"/>
    <dbReference type="EnsemblBacteria" id="SLM46941">
        <property type="protein sequence ID" value="SLM46941"/>
        <property type="gene ID" value="NSJP_0769"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0769"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047810">
        <property type="term" value="F:D-alanine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046416">
        <property type="term" value="P:D-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005784">
        <property type="entry name" value="D_amino_transT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01121">
        <property type="entry name" value="D_amino_aminoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="279" mass="30435" checksum="E4A1B60AED3FF40B" modified="2017-06-07" version="1">MPEVAFLNGRFLPLADATVSIEDRGFQFGDGVYEVIRTYRGRPFEVAAHLARLDRSARAIQLHQPYPEARWSQLILEGIERAAYPESKIYLQVTRGAAPRDHSYAADLVPTVVMTVRELQPIAAAVKSRGVAAMTTEDIRWGRCDVKSINLLANVLARQQAKQTGVYETILVKDGSVTEGSVSNVVVVRDGSLITAPEGPRILSGVTRAVVLRLARDHGVAVHERYPSQGDLFAAEEVFLTGTTVEVLGVVEIDGKTVGSGQPGRLTNRIAEWFSAQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1T9</accession>
    <name>A0A1W1I1T9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG</name>
        <name evidence="1" type="ORF">NSJP_0657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46829">
        <property type="protein sequence ID" value="SLM46829"/>
        <property type="gene ID" value="NSJP_0657"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0657"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="242" mass="25047" checksum="687466497E6664D8" modified="2017-06-07" version="1">MAMIKRAIVTGGSGGIGAAVCEALARDGHHVIVHGHRHMDRAQTVVDAICDKGGSAEAIAFDVTDREQTAAALATLLEAGPIQMIVNNAGIYSDGPLAGMEPSDWETVIDVSLKGFFNVTQPLLLPMMQMRWGRIVSITSVSGLIGNRGQVNYAAAKAGLHGATKALALEVASRGITVNAVAPGLIATPATDQLFDKDTITRLVPMKRAGTAQEVAGLVAYLVSDSAAYISGQIISVNGAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1X9</accession>
    <name>A0A1W1I1X9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase_H_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0844"/>
    <dbReference type="EnsemblBacteria" id="SLM47016">
        <property type="protein sequence ID" value="SLM47016"/>
        <property type="gene ID" value="NSJP_0844"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0844"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="1">
        <location>
            <begin position="88"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="180" mass="20624" checksum="F82D6E73A36D02A1" modified="2017-06-07" version="1">MIESSFCFLPGVGPRSEPRLWEDGITTWAAFLARDSIQGIGRTRKALYNDSLSQAQDHRAIEDARYFGAALHQRDHWRLYDWLRSRALYLDIETDSFGQITVVGLYGRGQFTALVRGESLDRRRLFDEFLHYDLLVTFCGGTFDLPKLLASYPSLPLDHPHIDLCFLGKRLGYRGGLKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I254</accession>
    <name>A0A1W1I254_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase</fullName>
            <ecNumber evidence="3">3.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybgC</name>
        <name evidence="3" type="ORF">NSJP_0916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0916"/>
    <dbReference type="EnsemblBacteria" id="SLM47088">
        <property type="protein sequence ID" value="SLM47088"/>
        <property type="gene ID" value="NSJP_0916"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0916"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006684">
        <property type="entry name" value="YbgC/YbaW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003230">
        <property type="entry name" value="YbgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00051">
        <property type="entry name" value="TIGR00051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="13"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="133" mass="14794" checksum="FC5047C93DBAE90D" modified="2017-06-07" version="1">MDIRIYYEDTDCGGVVYYANYLKYFERARTAHLEERGCSVKQLMDEGTVFVVVHAELTYRSPARYGDTLTIDTSVTDLSSASLTFSHVVKDKQSGRLVVEGSARLAATDGGGKVRRLDKAIADALRPAEKEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2G8</accession>
    <name>A0A1W1I2G8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1015"/>
    <dbReference type="EnsemblBacteria" id="SLM47187">
        <property type="protein sequence ID" value="SLM47187"/>
        <property type="gene ID" value="NSJP_1015"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1015"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="138" mass="15974" checksum="C7DA18C7F1C461AF" modified="2017-06-07" version="1">MAVQVYGCNHVVIEVTDAKKAVKFYSDVFGLKMLRGGEGAAWCKLGEHQFMAIFEVERLQPDRVKHFGLMVSDAKQIREVRRKLTKKYKLKLQPNFRCDFHDPWGNRIQVGDLSDESLVWLLPYQEVQKAGITFGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2I0</accession>
    <name>A0A1W1I2I0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47220">
        <property type="protein sequence ID" value="SLM47220"/>
        <property type="gene ID" value="NSJP_1048"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1048"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="37" mass="4031" checksum="96C11B45D13E8FFA" modified="2017-06-07" version="1">MMELTTSCVLASLNASTDWDVRLDISLAVAFMDGHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2P2</accession>
    <name>A0A1W1I2P2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cobalamin B12-binding/Radical SAM family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_0977</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0977"/>
    <dbReference type="EnsemblBacteria" id="SLM47149">
        <property type="protein sequence ID" value="SLM47149"/>
        <property type="gene ID" value="NSJP_0977"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0977"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027564">
        <property type="entry name" value="HpnR_B12_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00565">
        <property type="entry name" value="hopanoid_C3-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="B12-binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="182"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="512" mass="58043" checksum="BB2F88F68FB35BE8" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2X6</accession>
    <name>A0A1W1I2X6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_1186</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47358">
        <property type="protein sequence ID" value="SLM47358"/>
        <property type="gene ID" value="NSJP_1186"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1186"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="132"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="261"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="417"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="668"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="629"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="783"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="629"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="799"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="816" mass="90806" checksum="4AC2726FFC58F363" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I355</accession>
    <name>A0A1W1I355_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1268"/>
    <dbReference type="EnsemblBacteria" id="SLM47440">
        <property type="protein sequence ID" value="SLM47440"/>
        <property type="gene ID" value="NSJP_1268"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1268"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1178" mass="126886" checksum="D2CEE5CBF953BA0A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3C1</accession>
    <name>A0A1W1I3C1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1326"/>
    <dbReference type="EnsemblBacteria" id="SLM47498">
        <property type="protein sequence ID" value="SLM47498"/>
        <property type="gene ID" value="NSJP_1326"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1326"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="171"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="403" mass="44985" checksum="C4F16EC09C7C8DB5" modified="2017-06-07" version="1">MRGVIDQIHLDRVRAVQLALKEAGNADGWLFYDFRGSDPLSYRILLLDPATHVTRRWYYWIPAEGPPQKLLHRIEPHVLDPLPGESHLYVSWDEQRELLARILEGRRRIVMQYSPMNAVPYVSRVDAGTVELVESLGVEVASSGDLIQTFEAVWTDAQLESHQYAATALRRIVDEAFAHVRETLVAGRILTEFDVQQFILGRIREADMTTSSAPIAAVNAHSADPHYGPGPSGSAVIRRDDLVLIDLWAKRTTAGSVYADITWTAFAGRSVPDKHRSVFGLVRQGRDAAVNFVRAQLAAGVHPFGWEVDHVCRRVIETAGYGAQFLHRTGHSIGEEVHGNGANIDGLETQDTRRLIPRTCFSIEPGIYLPGEFGIRSELDVYLSEREALVFGLPLQEELSPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3F8</accession>
    <name>A0A1W1I3F8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase III subunit gamma/tau</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">dnaX</name>
        <name evidence="7" type="ORF">NSJP_1343</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1343"/>
    <dbReference type="EnsemblBacteria" id="SLM47515">
        <property type="protein sequence ID" value="SLM47515"/>
        <property type="gene ID" value="NSJP_1343"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1343"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18137">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022754">
        <property type="entry name" value="DNA_pol_III_gamma-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045085">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12169">
        <property type="entry name" value="DNA_pol3_gamma3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="37"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="602" mass="65528" checksum="2CBF16F8ADFC02C4" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3G5</accession>
    <name>A0A1W1I3G5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_1211</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1211"/>
    <dbReference type="EnsemblBacteria" id="SLM47383">
        <property type="protein sequence ID" value="SLM47383"/>
        <property type="gene ID" value="NSJP_1211"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1211"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="387"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="485" mass="54255" checksum="6EB797B92F8A935E" modified="2017-06-07" version="1">MKLRRSQFLIGFVTAFLVVLTIWACVSDRNSLAQPTSPDGKPGSTPSIDAAKKKGFDGVDFSYDPFGAPPGQDAVLSAEQVMKKDVSEKPAVMKRQQQLLQDRYDMACRSASGAVMTKGKSQPVGPAVKLPSGTTWEQLAQLTPEEIKKKSGFPRGFDRLPHVKHAVGGMVFPSMQIKDFPRLERFDVDFDLPDCFLPEFPPPIFLTTHPELGDVSQGEVLSAENFDRLFRGLITPVQLDGLRMLVTQFPQEEFNATHDRKTAKPSLGVACLDCHVNFHTTGQFHLNPDTRPQLDRLRLDTTSLRGMYNQQIHGSKRSLRSVEDFTEFEQRTAYFNGDSIRAMKKGINMIDRLQVAHMAQMQSMIDFPPAPHLDPMTGRLDRAKATQMEIRGEELFFGKAKCVACHAPPSYTDHQMHDLQLERFGAMGDGPIKTFVLRGIKDSPPYFHDGRLPTLEDTVEFFNLVGGLKLEAEDKKALTAFLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3L1</accession>
    <name>A0A1W1I3L1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADP-ribose pyrophosphatase</fullName>
            <ecNumber evidence="3">3.6.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nudF</name>
        <name evidence="3" type="ORF">NSJP_1369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1369"/>
    <dbReference type="EnsemblBacteria" id="SLM47541">
        <property type="protein sequence ID" value="SLM47541"/>
        <property type="gene ID" value="NSJP_1369"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1369"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="170" mass="19010" checksum="ED6E02D4A97039DE" modified="2017-06-07" version="1">MVKSIYKGRVITVNIDTVRLPNDTIIDLEIVRHPGASAMVPIKEDGTVILVRQFRHAAGGFIYEIPAGKLHAGEDPKLCAARELEEEIGYRAEHYTLLSSILTAPGFTDEVIHIYKATGLIKTQQRLDQDEVLEVVELPLPEVMTMIHDGRIRDAKTMVGCQLVFFSTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3P3</accession>
    <name>A0A1W1I3P3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47614">
        <property type="protein sequence ID" value="SLM47614"/>
        <property type="gene ID" value="NSJP_1442"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1442"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="159" mass="17986" checksum="A1A9782964F45C52" modified="2017-06-07" version="1">MRILLAIDESESSHRAVKYVGSLLHRTPDVAITIFHVLKPMPRGLLEHGGSESPAVEAQMDQQLHKDQEDWIRKQRESQCHVLQSACQTLKDSGFDIQRVTLKFGHEDDIARNILEEARGHETIVVGRHGMSRIKRLFGGGVTDQILRDAKGFAIWIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Q7</accession>
    <name>A0A1W1I3Q7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1347"/>
    <dbReference type="EnsemblBacteria" id="SLM47519">
        <property type="protein sequence ID" value="SLM47519"/>
        <property type="gene ID" value="NSJP_1347"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1347"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="305"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="390" mass="43292" checksum="3E76D3FEEB7838F4" modified="2017-06-07" version="1">MMLPGTRNDPPRRTGVVAAGLVGLAFLLGACETPNPRQANLPPSESDLALLKSASLCERKEHFLQQHPPSALKVTPWGTGQELMVPADQSPLHGDESYFFDEDGVLAGVLYTFRTGLDLDPYPTLRHTLSMLRPVMEFYLHVPGLSTESSFDSSALYETGDEKTTTQYLVIGFKERPTLLQASVTTDPYVRLFSPYRREFLARLKSTGTKKEGQRIDPQGSEDKEPFASLQQFARGQTAQLSYCGPQDYRVAADAYQKAIAGGFTNKVWQAEVHHKYGQALFGLGQYEKAKSEMLQSLAIRPNTPDTLNNLGSTYLKLGDKAAAQAAFEKAIILRPNYAIARFNLAETVEPMNPKRALTEYETYLALAEGIPEEADRVALVQQRVKKMKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Q9</accession>
    <name>A0A1W1I3Q9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Sulfite reductase, contains SirA-like domain (Modular protein)</fullName>
            <ecNumber evidence="9">1.8.7.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_1460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1460"/>
    <dbReference type="EnsemblBacteria" id="SLM47632">
        <property type="protein sequence ID" value="SLM47632"/>
        <property type="gene ID" value="NSJP_1460"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1460"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="7">
        <location>
            <begin position="55"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="5">
        <location>
            <begin position="130"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="7">
        <location>
            <begin position="342"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="5">
        <location>
            <begin position="421"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="HEPN" evidence="8">
        <location>
            <begin position="607"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="UPF0033" evidence="6">
        <location>
            <begin position="745"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="817" mass="89590" checksum="1B065DC6DA356BB4" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3R0</accession>
    <name>A0A1W1I3R0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein NSJP_1468</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yebC</name>
        <name evidence="5" type="ORF">NSJP_1468</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1468"/>
    <dbReference type="EnsemblBacteria" id="SLM47640">
        <property type="protein sequence ID" value="SLM47640"/>
        <property type="gene ID" value="NSJP_1468"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1468"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="252" mass="27373" checksum="8E451F824C5DBF31" modified="2017-06-07" version="1">MGGHSHWATIKRHKSAQDAKRGKIFTRIIRELTIAARGGGDPDGNPRLRLAIAKAKEANMPGDTMKKAIQRGTGELPGVSYEEFSLEGYGPGGTALLLEITSDNRNRTVAEIRSLFTKNHGNMAEAGAVAWQFHKKGLLTIDKGKVEEDALLSLALDAGAEDVKSGEKSFEVITNPQDFEAVKKALADAKVDPSLAELTFVPQNTIRLEEKDAEQMLKLMEVMDEHDDVQKVHANFDIPDDVMEKVAAAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3S5</accession>
    <name>A0A1W1I3S5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">30S ribosomal protein S1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsA</name>
        <name evidence="6" type="ORF">NSJP_1480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1480"/>
    <dbReference type="EnsemblBacteria" id="SLM47652">
        <property type="protein sequence ID" value="SLM47652"/>
        <property type="gene ID" value="NSJP_1480"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1480"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000110">
        <property type="entry name" value="Ribosomal_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00717">
        <property type="entry name" value="rpsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="31"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="114"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="200"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="285"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="372"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="460"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="541"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="571" mass="63571" checksum="894874F4F4B58197" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3W0</accession>
    <name>A0A1W1I3W0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47707">
        <property type="protein sequence ID" value="SLM47707"/>
        <property type="gene ID" value="NSJP_1535"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1535"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011963834" evidence="1">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="103" mass="11614" checksum="B478CD0A76833650" modified="2017-06-07" version="1">MKRLLWLPALCMLLTACGGDNPYLEASLKPAEMQGKDKAWFEKNWGAPDGKSPRFFGGETWTYYRIAGGKTSAPLFNFSPNQCQITLKFDKEEKLSDYSYSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Y2</accession>
    <name>A0A1W1I3Y2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dapL</name>
        <name evidence="6" type="ORF">NSJP_1546</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23988"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="EC" id="2.6.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1546"/>
    <dbReference type="EnsemblBacteria" id="SLM47718">
        <property type="protein sequence ID" value="SLM47718"/>
        <property type="gene ID" value="NSJP_1546"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1546"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010285">
        <property type="term" value="F:L,L-diaminopimelate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01642">
        <property type="entry name" value="DapL_aminotrans_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019881">
        <property type="entry name" value="DAP-NH2Trfase_DapL_Desulfo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019942">
        <property type="entry name" value="DapL/ALD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03540">
        <property type="entry name" value="DapC_direct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="5">
        <location>
            <begin position="36"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="391" mass="42396" checksum="BF9BF812D35D0C5C" modified="2017-06-07" version="1">MAGFPIEVANRIKTLPPYLFAAIDKMKQEAIARGVDIINLGIGDPDLPTPGPIIDSLAQAAKNPKHHQYPSYEGMLAFRKAVADWYKRRFNVSLDPADEVLTLIGSKEGIGHIHLAFVDPGDVVLVPSPGYPVYPVGTGFSGGVSHIMPLTKANGFLPDLNAIPKEVAQKAKLMWLNSPNNPTSVIMTKDYFKRVVEFAQTYHVIVCHDAAYSEIFYDGKRPSSFLEVDGAKDVGVEFHSLSKTYNMTGWRIGFVVGNKSVLAGLGKVKSNLDSGVFEAVQAAGITALGLDDTVTDGLRKIYQERRDTLVPGLKKLGLEVDPPPAAFYVWVTVPKGYTSASFTAHLLEKAGIVTTPGNGFGTPGEGYIRMTVCTTKERLAEAVERIKKAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Z3</accession>
    <name>A0A1W1I3Z3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47720">
        <property type="protein sequence ID" value="SLM47720"/>
        <property type="gene ID" value="NSJP_1548"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1548"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="167" mass="19005" checksum="7521DB9D1F0C2821" modified="2017-06-07" version="1">MKEPDLDWLVHNRSAIQELLLELWKEFPETPSADSQPGAALQLLVGVTFSLWRAVFLAESPRDWQEHASHAKKFLHLVVKEQTMGHAQEREARYWTVGYYLTSAFLRLESAYAMLNYDSPLRGLVTRFIVRRGGTIDEAADPKAPWETAVGAVRDLLGEARRRLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I483</accession>
    <name>A0A1W1I483_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Thiol-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1642"/>
    <dbReference type="EnsemblBacteria" id="SLM47814">
        <property type="protein sequence ID" value="SLM47814"/>
        <property type="gene ID" value="NSJP_1642"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1642"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="45"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="188" mass="20388" checksum="CEE36231D35CB129" modified="2017-06-07" version="1">MFHDRILWNGLALIAGALVLAAAGLSGLAGAATSDPFAALRVTPSAARAPVMPFDLTTLDGRPVRSQDLAGKVVLLNFWATWCGPCKEEMPSLARLQTRFDSAQVQILTVTADRHPQGIRQFFDQLGISLPVLFDEDQEVSRTFMVRGLPTTVLIGPDGRVSGRAVGPRAWDSDESIALMRHLLEEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I489</accession>
    <name>A0A1W1I489_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47828">
        <property type="protein sequence ID" value="SLM47828"/>
        <property type="gene ID" value="NSJP_1656"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1656"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012167336" evidence="1">
        <location>
            <begin position="24"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="158" mass="17090" checksum="C968B42C57F5C250" modified="2017-06-07" version="1">MVRRVIIGFMGLLSIAFTGSAWALHAGGVEVGDLETGSVVGQPFKELDIDAELFAIDIGNLKTWYPPVTVIDFKVRPGRPVLLRVTNSSSAQRGFQMTDAVSAATPTVLKAEVVLKPGETRYIGIPTSDLFYATQGNTLTYRDHLNPKDPGGKLVMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4G5</accession>
    <name>A0A1W1I4G5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Cell division protein DivIVA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_1745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1745"/>
    <dbReference type="EnsemblBacteria" id="SLM47917">
        <property type="protein sequence ID" value="SLM47917"/>
        <property type="gene ID" value="NSJP_1745"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1745"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794">
        <property type="entry name" value="PTHR35794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05103">
        <property type="entry name" value="DivIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="104"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="170" mass="19623" checksum="B132E3149AB39A59" modified="2017-06-07" version="1">MKITPLDIQQMVFKTSFRGYDKEEVNRFLEEIAETVELLNRDNAVQREKIVLLEQQITELKRTEVTLSNTLVSAQSLAEDVKRSAQRESDLVIKEAELKAGEMIRQARVELHNTQRDLTALQKQRLLMVERLRATLRTFERMLEVEEQEAFSDAASTSENKLEGQSSQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4K6</accession>
    <name>A0A1W1I4K6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2914 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1699"/>
    <dbReference type="EnsemblBacteria" id="SLM47871">
        <property type="protein sequence ID" value="SLM47871"/>
        <property type="gene ID" value="NSJP_1699"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1699"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022606">
        <property type="entry name" value="DUF2914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11141">
        <property type="entry name" value="DUF2914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2914" evidence="2">
        <location>
            <begin position="287"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="368" mass="41662" checksum="70A0D507359276D7" modified="2017-06-07" version="1">MSPLGKVQSILAKPFMPAVFFFSGVTYDTLTLTRIDRLQDNLLLLLYILLLGTLIVLTGRLGIEPPPDRAQLASFPPLVRWTLGSRPYYPMVSQFLLGGLFSAYAVFYSRSASLTGTAVFFGLLVLLLVGNEFLRDRLSNLRLTVSLYALVCFSFFTFFLPVMTGLMNAAMFLLGAVLSGLVTLRVVELIYRNNPDRSRREAVGVTAPALALIALLVSFYFLNWIPPVPLSLKFGGIYHEVKKSDDRFELSYAKKWYEVWKRSDTVFPADEPVYCFTAVFAPVSLNTTVYHHWYFRARHDRPFTHADRIPVRISGGREGGYRAYTFKQRLDSGEWRVDVESEDGRIIGRVSVTVEQDYGMGPLVTTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4L5</accession>
    <name>A0A1W1I4L5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="7">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="7">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">fabH</name>
        <name evidence="10" type="ORF">NSJP_1768</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1768"/>
    <dbReference type="EnsemblBacteria" id="SLM47940">
        <property type="protein sequence ID" value="SLM47940"/>
        <property type="gene ID" value="NSJP_1768"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1768"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="9">
        <location>
            <begin position="107"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="8">
        <location>
            <begin position="235"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="7">
        <location>
            <begin position="252"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="324" mass="34470" checksum="62B683488FADA17A" modified="2017-06-07" version="1">MRARITGTGSYAPPKVLTNRDLEAMVATSDEWIIERTGIRERRVAASGEACSDLAVRAAEQALRAAGVRAEDLDLILLATCTGDYPLPATACLVQHRLGAVRAAACDLSAACCGFVYALSVADAYVRTGMRHVLVIGSEVMSAILDWSDRNTCILFGDGAGAAVVSGVQGDAGILSTHLRSDGGLHELIAVPAGGSRLPLSEKVIAEKMNCVKMKGNETFKVAVRMLEEIARETLASNNLTVEDIDLYVPHQANIRILKAVAERLGLPLEKIMLNLDRYGNTSAASIPIALDEAVRQGRIKEGSLVMLGAFGAGLTWASALIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4U9</accession>
    <name>A0A1W1I4U9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1862"/>
    <dbReference type="EnsemblBacteria" id="SLM48034">
        <property type="protein sequence ID" value="SLM48034"/>
        <property type="gene ID" value="NSJP_1862"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1862"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="55"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="106" mass="11749" checksum="631B1984D0B02ECD" modified="2017-06-07" version="1">MQIFSFDELLADPAKAATLSPQIAQSFLIALASLHPVLLHRALEGSHNVSNQDHLLTIPEVAKRLQVSNYRAYELARSGILKSVRFGKSVRVRASAIDEYVSQHEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4V7</accession>
    <name>A0A1W1I4V7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_1858</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1858"/>
    <dbReference type="EnsemblBacteria" id="SLM48030">
        <property type="protein sequence ID" value="SLM48030"/>
        <property type="gene ID" value="NSJP_1858"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1858"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010701505" evidence="6">
        <location>
            <begin position="26"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="29"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="244"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="338" mass="37286" checksum="411F806139594FE4" modified="2017-06-07" version="1">MKAARLRVMGAVAGLMGLWALVAGGCANEQQKKGHELYAHYCMHCHGENGRQNEGFNWSSMPDPKPKDLSNKSEMGTFKDEEIFNTISRDMKDTSPGGDKIGDDEFAVPTMPTFKYTLSEDEIWAIVAYVRGLHGMKLEFKVEERKKELTEHLQAAQSKFDQSKQEYEAAEKRASDEAEKKSAQLKKDVDVDESSYAKEQAAMTQAKKEFDAAQVALNNFSTRPGKGVNVARPDLTVKPDQAAKLAEVGKNLYANKYGCNGCHSLAEEGGKVGPALDRAGFRLNGTWVYRWLKNPQAMKPETRMPALGLSDADAKAVVMYLNTLRAPKAEPASDKPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Y1</accession>
    <name>A0A1W1I4Y1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48052">
        <property type="protein sequence ID" value="SLM48052"/>
        <property type="gene ID" value="NSJP_1880"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1880"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="115" mass="12468" checksum="B6EC442A7CA359D4" modified="2017-06-07" version="1">MNEVSQPVSEQRGMSGAEGNTLPQYASTLRSNQHVVGLTFLLVRSMVTAEGTVLLHFDTVGIILLILRCPIDRFPRCRTTGTSQGNDLTHDQVSLLPLEGLSSGSHPVMLFCDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I512</accession>
    <name>A0A1W1I512_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Purine nucleoside phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NSJP_1741</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:24409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:27643"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27647"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:11853"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1741"/>
    <dbReference type="EnsemblBacteria" id="SLM47913">
        <property type="protein sequence ID" value="SLM47913"/>
        <property type="gene ID" value="NSJP_1741"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1741"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16833">
        <property type="entry name" value="YfiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003730">
        <property type="entry name" value="Cu_polyphenol_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038371">
        <property type="entry name" value="Cu_polyphenol_OxRdtase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30616">
        <property type="entry name" value="PTHR30616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02578">
        <property type="entry name" value="Cu-oxidase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00726">
        <property type="entry name" value="TIGR00726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="246" mass="27011" checksum="EB96530765DBAD47" modified="2017-06-07" version="1">MHTNLPVITVPAFASSRDGVRHFFGTRRHADSLALAIGVPAAAAGSRGKGWLLSVKQVHGTDALVLDRPLIEGDRFDGGWDALVTDQPGVTVTVRTADCVPVLIYDRRRRAVAAVHAGWRGAVAEIVPKTIDLLMARFHVMSEDLRVSIGPSAGPCCYEVDEPVLSALRRQMPEWESVVRNAGEGRAQLDLKTLIRRQVERIGVAPLHVTSVNLCTICHDDLFYSYRREGRVNGTMVSGIMLMPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I517</accession>
    <name>A0A1W1I517_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48104">
        <property type="protein sequence ID" value="SLM48104"/>
        <property type="gene ID" value="NSJP_1932"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1932"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="104" mass="11578" checksum="2DF82E0E7E048905" modified="2017-06-07" version="1">MPPLASKPAVAVVILTKLVFVTLRPLATSNGAQAYLTRGAINWIWRFGRPWLQWGRKKSEPNYSTKTEGPSIEVGRHQAAWQCSTSHQSLGKGLRCASLPLSYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I596</accession>
    <name>A0A1W1I596_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Proteasome, beta subunit</fullName>
            <ecNumber evidence="1">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.25.1" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1983"/>
    <dbReference type="EnsemblBacteria" id="SLM48155">
        <property type="protein sequence ID" value="SLM48155"/>
        <property type="gene ID" value="NSJP_1983"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1983"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="257" mass="28029" checksum="43B114A8B1FA9160" modified="2017-06-07" version="1">MGMQGDLFQLLKEQGYQFGLPAAAAADVDIPTATTILAFRYRDGVLVAGDRRATAGNMVMYDRTDKVLEIDRYSVMAIAGVPATAYEMARVLEHSFKYYRRTQLQELSFEGKLRALSKLLKENVPAALAGTGAVAPIFAGYDAEQGMAKTYFYDILGAEFEGVEYAVSGSGSPTLRGILHYLNTWGEQPLTGMAEEQAAIQALRLLTCAAEFDSATGGVNREANLYPVIKLITQDGIRTVSDTDLKQSFEANVIRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5C0</accession>
    <name>A0A1W1I5C0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2018"/>
    <dbReference type="EnsemblBacteria" id="SLM48190">
        <property type="protein sequence ID" value="SLM48190"/>
        <property type="gene ID" value="NSJP_2018"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2018"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="41"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="120" mass="13628" checksum="E755D05338A00C07" modified="2017-06-07" version="1">MLKVTLSERPEFLAGDHTRLREIFHPAKHHLQLGYSLAHGTLDPGQRSKRHVLKSSEVYYFIAGRGRFLLNNREIPIEAGTTLYVPPGGEQSLENTGSQVIEFLCLVDPAWKMEDEQVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5G0</accession>
    <name>A0A1W1I5G0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48119">
        <property type="protein sequence ID" value="SLM48119"/>
        <property type="gene ID" value="NSJP_1947"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1947"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="48"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="226" mass="24829" checksum="71A32FB04036A4D9" modified="2017-06-07" version="1">MDGDVMPLLPQAAYDRWSGVYDDADPSTSLDEPFLLAMVTPFTGCRILDLGCGTGRYLRLVNQPGASVVGMDLSQGMLVRAMQTLVPKASIAWVQASFERFPFADGSFDRVISGLILDHVHDLRSFFHQIAAVLRPGGRLILSAVHPMMQRLTGATVRFVVQGQEYHVQGTVHEVETIAESVQEAGLDIENLLEPEVDQELIARYPVWRARLGCPALMLLAAHKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5K6</accession>
    <name>A0A1W1I5K6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secG</name>
        <name evidence="11" type="ORF">NSJP_2112</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2112"/>
    <dbReference type="EnsemblBacteria" id="SLM48284">
        <property type="protein sequence ID" value="SLM48284"/>
        <property type="gene ID" value="NSJP_2112"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2112"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34182">
        <property type="entry name" value="PTHR34182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="116" mass="11803" checksum="8A241E5FFC5CEC77" modified="2017-06-07" version="1">MHTLTIIIHVLACFLMIGAILLQSGKGAEIGAAFGGSSQTVFGSRGPANFLSKFTVVVAAVFMITSLSLAILAKNQTFSSTVIDLKKKDAPPASPAPADKPAGDSHSDSSSSSSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5K7</accession>
    <name>A0A1W1I5K7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48113">
        <property type="protein sequence ID" value="SLM48113"/>
        <property type="gene ID" value="NSJP_1941"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1941"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="157" mass="17634" checksum="73D8B3C3AD866349" modified="2017-06-07" version="1">MFYQKIRQCSPLDPSEMLWIELDSGVCRPITLDEYIYPVTPTHSGRSDSDIGILLARSQQVRGMMMNTRTTNSPQSPQSRVLMRVWSWLVYDAVEADAMCLCACHLGAVRHSTACICAPCPSCRLRIQAARMSEHRCQCREAEKGGRQNAVETPRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5L4</accession>
    <name>A0A1W1I5L4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excisionase family DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48265">
        <property type="protein sequence ID" value="SLM48265"/>
        <property type="gene ID" value="NSJP_2093"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2093"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="9"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="65" mass="8043" checksum="C7083FCBF07C140B" modified="2017-06-07" version="1">MSRSSKSELMTAEETCRYLKITQRTLYRYLRSRRIPAFKLGSQWRFVRSDLEQWIRERMRTPLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5P5</accession>
    <name>A0A1W1I5P5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized ATPase, AAA family</fullName>
            <ecNumber evidence="4">3.6.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1981"/>
    <dbReference type="EnsemblBacteria" id="SLM48153">
        <property type="protein sequence ID" value="SLM48153"/>
        <property type="gene ID" value="NSJP_1981"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1981"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041626">
        <property type="entry name" value="Prot_ATP_ID_OB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17758">
        <property type="entry name" value="Prot_ATP_OB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="256"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="580" mass="63998" checksum="37877431F2856425" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5R5</accession>
    <name>A0A1W1I5R5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase</fullName>
            <ecNumber evidence="2">2.7.1.49</ecNumber>
            <ecNumber evidence="2">2.7.4.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiD</name>
        <name evidence="2" type="ORF">NSJP_2175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.49" evidence="2"/>
    <dbReference type="EC" id="2.7.4.7" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2175"/>
    <dbReference type="EnsemblBacteria" id="SLM48347">
        <property type="protein sequence ID" value="SLM48347"/>
        <property type="gene ID" value="NSJP_2175"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2175"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="1">
        <location>
            <begin position="15"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="266" mass="28295" checksum="0D05721D328C7B4B" modified="2017-06-07" version="1">MNTTLKQVLTIAGSDSGGGAGIQADIKAMSANGVFAMSVITAITAQNTQEVTDVFELPTSIIAAQIDAVFDDFDVAGVKIGMLSSAAVIDVVARLLNPQKVANLVVDPVMISKTGHPLLKPDAIEALKTQLFPLALLVTPNIHEAQQLSGIEIKSLADARRAAKVIHGFGCRHVLIKGGHLITERGTDLLYDGRFFHVFRSPFIETPHTHGTGCTFASAITAQLARGKALNDAIQTAKNYLTEAIRHGLAIGHGHGPTNHFYFLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5R8</accession>
    <name>A0A1W1I5R8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Thiol peroxidase (Modular protein)</fullName>
            <ecNumber evidence="2">1.11.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2180"/>
    <dbReference type="EnsemblBacteria" id="SLM48352">
        <property type="protein sequence ID" value="SLM48352"/>
        <property type="gene ID" value="NSJP_2180"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2180"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03014">
        <property type="entry name" value="PRX_Atyp2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002065">
        <property type="entry name" value="TPX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Redoxin" evidence="1">
        <location>
            <begin position="74"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="227" mass="24478" checksum="E850473B744BD3F9" modified="2017-06-07" version="1">MTEPGIVMTVPRMRRPLLLLAAGTLVLSGCMGSGSGSVFTYKNLPVADGTAQTGEGHTVLYKGSPMVLTGTGIKTGDQLRDVKVAQADLSLINIAETKGKGRVRIISVVPSLDTKVCEQQTHILSGQNKGLDRMVELITVSIDTPFAQKRFATDAKIANVTFLSDYRSADFGKTYGLLLKDPHILARAVMVVDPHNKVRYIQVPPELGQLPDMEEAFNVARSLITAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5U6</accession>
    <name>A0A1W1I5U6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_2210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48382">
        <property type="protein sequence ID" value="SLM48382"/>
        <property type="gene ID" value="NSJP_2210"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2210"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="556" mass="64354" checksum="FA47CBEB47DE8A4B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I645</accession>
    <name>A0A1W1I645_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC_transp_aux domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2310"/>
    <dbReference type="EnsemblBacteria" id="SLM48482">
        <property type="protein sequence ID" value="SLM48482"/>
        <property type="gene ID" value="NSJP_2310"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2310"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019196">
        <property type="entry name" value="ABC_transp_unknown"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09822">
        <property type="entry name" value="ABC_transp_aux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="ABC_transp_aux" evidence="2">
        <location>
            <begin position="96"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="509" mass="56290" checksum="43A5519C8683450F" modified="2017-06-07" version="1">MEMNLRTLPLGVLGTALAVAGLVAYSLAPEKLWLVTVVEGLALVCLVAFFIVHFQSLKSFSSRRSTRLGANSLILTLLLVAILAIINFLSARHSVRWDLSENQNFSLAPQTHRVLRSLPRDVKVTVFTREKDAGYQSYKERLDSYRQASPKLAVEFIDPERQPKAAQSYGITRTDTAIFESGTQTVRVTNPSEAELTGALMRVSRDEKKRILFLEGHGEHSLTDRERTGFSSAKELLIRQGYQIDSISLLSQPSVPDGTAILALAGPRKPITSDELDRIRTYVDAGGRLLLMVDPDTQADLSPLLSRWGLGLGPGVLVDLQDRLAQGDLTALLVRTFTEHEITQDLNAAVLFPLARHITFDEQTGKDWDYVPLARTSPNSWAETDLKGRVVGLNEKEDIKGPLPMAAALAPKAPPVEGKPRPGIVIIGNSTFATNGFVNFPGNSDFLLHTTGWLAEDRELLAIGPRDQALRPFIPNPIQERTLLYVQVILIPALLCMIGLTVWRKRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6J8</accession>
    <name>A0A1W1I6J8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48632">
        <property type="protein sequence ID" value="SLM48632"/>
        <property type="gene ID" value="NSJP_2460"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2460"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="79" mass="8571" checksum="A04696AA833E519A" modified="2017-06-07" version="1">MDEIEAGKQRLLEIVKAIDPAVQVVIPVSSSNSMFLISLTKGPNRKFITLPEDDIIDLPNEPGIETKVTKVVKDAVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Y2</accession>
    <name>A0A1W1I6Y2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-ketoacyl-CoA thiolase</fullName>
            <ecNumber evidence="6">2.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fadI</name>
        <name evidence="6" type="ORF">NSJP_2593</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2593"/>
    <dbReference type="EnsemblBacteria" id="SLM48760">
        <property type="protein sequence ID" value="SLM48760"/>
        <property type="gene ID" value="NSJP_2593"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2593"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="4"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="299"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="441" mass="47594" checksum="56422F9E4130F4F6" modified="2017-06-07" version="1">MRNVVVVDAFRTPLCKEGTDFSGTDAEVLGAWVVRELIMRCHRWNLPLTTIDCVLGSNVATPMHAVNPTRVAAVTGGLPATIPADTVAGKNCGSGVTALYYASLRIRSGDADTVLAMGMEAMSRIPVVYDRTVADLILRYGKGRTFRERAGAALSLIPKLLNLKRYPPRVGLVMGLTDPMCDLIMGLTAENISKDPELRISREEQDAYAVQSHQRAARAWKNGLFADEVVTTYVPERQAYVTHDNGIREDASLETFGGVRPVFDRFHGSVTPANASQITDAAAAMLLMEEEKAKSLGLPILGYVREYADFGYEPSCMGLAPVGAIASLLAKTGLSLKDFAVCEINEAFASVVLGITRILDSSALMERKFGRYGWTERLGHIPSDDLNPHGGAIALGHPVGVSGLRLAMTALYELRRRNAQRALISACVGGGQGVAMIVERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I777</accession>
    <name>A0A1W1I777_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative peroxiredoxin bcp</fullName>
            <ecNumber evidence="5">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bcp</name>
        <name evidence="5" type="ORF">NSJP_2668</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.15" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2668"/>
    <dbReference type="EnsemblBacteria" id="SLM48835">
        <property type="protein sequence ID" value="SLM48835"/>
        <property type="gene ID" value="NSJP_2668"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2668"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="155" mass="17142" checksum="6772ABB88B64D56D" modified="2017-06-07" version="1">MGSTLEIGDKAPEFALPDQHGKTVSLKNFKGKQIVLYFYPKDDTPGCTKESCDFRDVESQIVRAGAVIVGVSMDGQDSHQKFIKKYGLPFPLLSDEDASISKSYGVYKEKNMYGRKSWGIERSTFVIDPAGTLKAVFRKVKVDGHADEVLTALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I787</accession>
    <name>A0A1W1I787_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48673">
        <property type="protein sequence ID" value="SLM48673"/>
        <property type="gene ID" value="NSJP_2501"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2501"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012709511" evidence="1">
        <location>
            <begin position="25"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="202" mass="21183" checksum="8FE5F098BF675735" modified="2017-06-07" version="1">MRKLSRIHPAWVALLLLASLGAKGCPAQVGCGVSGSMPGGARQFGAETWNCQVGMQFAQGNTVTTPQQAKTDLLAKKESAAVQVASLREKAAGGDQAFGFGGTGQSGTAAAEANSQLEAATRDFNTLSAQVTSIEQLQPPPGTTVLSEGTWNVQGDKAVFQTNAPYDPEKKYVIPFVVRSERGEVVEMGYIPVTSVQVEPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7I6</accession>
    <name>A0A1W1I7I6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49008">
        <property type="protein sequence ID" value="SLM49008"/>
        <property type="gene ID" value="NSJP_2841"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2841"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="59" mass="6545" checksum="B2E36BFA84DEC62E" modified="2017-06-07" version="1">MPVQPDTDTQAVGRCADCGKWNTHLVGYVDTLAPIRLELCDLCWHARQHRQNFSGGCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7V4</accession>
    <name>A0A1W1I7V4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_2898</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49065">
        <property type="protein sequence ID" value="SLM49065"/>
        <property type="gene ID" value="NSJP_2898"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2898"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="91"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="489"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="616" mass="68471" checksum="85048562CBAF9624" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7V7</accession>
    <name>A0A1W1I7V7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49097">
        <property type="protein sequence ID" value="SLM49097"/>
        <property type="gene ID" value="NSJP_2930"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2930"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="103" mass="11234" checksum="90A9EEB280F5E586" modified="2017-06-07" version="1">MPPIVLDPPNNGATYGNSYYFVPTNAHANHPLTLVAQWKITVTTAQNNGGSLVTQTNWSNTPIGTCLLSNLPANNGFYYTQIVYQPPTGGTFVSNSNKFRSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Y0</accession>
    <name>A0A1W1I7Y0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, Glucose/ribitol dehydrogenase family</fullName>
            <ecNumber evidence="2">1.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2943"/>
    <dbReference type="EnsemblBacteria" id="SLM49110">
        <property type="protein sequence ID" value="SLM49110"/>
        <property type="gene ID" value="NSJP_2943"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2943"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="293" mass="31023" checksum="A7D77FE00B2880D8" modified="2017-06-07" version="1">MMGVPASTRVVVITGASTGIGAACALMCVAQGMTVFAGVRTDEAGEALRQRGGERLIPIRLDVTDSESIRQAERVVRETVGLTGVNGLVNNAGIAVGSPLEVIPIEALRRQLEVNVIGQILVTQAFLPLLRLARGRIVNMGSIAGRGTIPVMGPYSASKHALEALTDALRLELQPWGLHVSIVEPGAIATPIWEKSTETGNEIAAAAGPAAVALYADLVSRVKDRIAQAANRAIPADVVAQTVLHALTAAKPKTRYLVGSDAKVRAVMLRWFPDRVQDWILTKVLALPAWNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I818</accession>
    <name>A0A1W1I818_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49188">
        <property type="protein sequence ID" value="SLM49188"/>
        <property type="gene ID" value="NSJP_3021"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3021"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013094139" evidence="2">
        <location>
            <begin position="27"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="202" mass="22164" checksum="3754AE126A11B248" modified="2017-06-07" version="1">MMMNAQIARRLMRNLLVMAIPMTLFAGAVAQGADEPVTPISPRQEEVSAPSQQLEISPPPSTTEGAPDDVQERGLGKGDFGQFKKDFQRKQPLPPSEPPAQLCHQETWMLTQCKCFSQTECQALTALFPNSCPPGSSHCEFTPMSRGAMPPLPPNLCSYQVPLTFTKCECHNQQECQLLTPFCQGSCPSGSTSCECTPMQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I852</accession>
    <name>A0A1W1I852_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3061"/>
    <dbReference type="EnsemblBacteria" id="SLM49228">
        <property type="protein sequence ID" value="SLM49228"/>
        <property type="gene ID" value="NSJP_3061"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3061"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="474" mass="51780" checksum="5CDD9895C9BCFBC3" modified="2017-06-07" version="1">MIAEVQHNVLSVLGILGQPGKIRRPARFADRLKVLAAYVLYRVGQWVYGRGWLWLARLTWRRASQIAPHVSELHHALAAVSHTEGHDLAAVAHTTTGLMLNPRDASMLHTRGTALYHLGETGAALACFRKALALQPDSRTCLSAAAFALLRAGDCPAGFAAYEARQYDPAVLLRLSGIPHWTGDDLNGKTVLVWTEQGYGDALQFIRYAPLLAQRAGRVFVLCPPALARLFRTLPGVTVVQTYDALGNVGQIDRHVPVGSLPYHFGTTLETILTEAYLSVPSGAHVTMPKADGFKAGLVWSGQVNTAHERRRAIPLETLSPLVRTSGTKWFSLQVGPAVQDLRRYGMTGLFHNLSPQLQDFADTASALSQLDLVVTVDTAVAHLAGSMGKPVWILLPYAADWRWFEGRTDSPWYRSARLFRQPWPGNWAGPIMAIRGALAEEVTARQRVTSSAEHPFAPGPLDGPEGDRLHTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8D4</accession>
    <name>A0A1W1I8D4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NIL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3099"/>
    <dbReference type="EnsemblBacteria" id="SLM49266">
        <property type="protein sequence ID" value="SLM49266"/>
        <property type="gene ID" value="NSJP_3099"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3099"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018449">
        <property type="entry name" value="NIL_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09383">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00930">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIL" evidence="1">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="79" mass="9216" checksum="1C1CBF290C763D7A" modified="2017-06-07" version="1">MSNMRFHIRFPEEKIKEPVIYQIGREYQVVTNVRRADVRETTGWMDLELTGETAEIERAVEGLRKKGVVVDPIELNVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8F7</accession>
    <name>A0A1W1I8F7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49083">
        <property type="protein sequence ID" value="SLM49083"/>
        <property type="gene ID" value="NSJP_2916"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2916"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="157" mass="17153" checksum="EB2B1A7A6410A15E" modified="2017-06-07" version="1">MIDAISCSSLTKKETFMRRLVRWPSAVLALIWIALSLGCDTTPHARPPQWTAVEITDAAKVAGKWEGILRRTPQNKRNDLVALIIEPDGQFRFTSVRTIGILSGEGTFAIKDGKLTFSSDRGTINAGLFEADGKRMLKAEGIASDGMTYSSELTPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8G8</accession>
    <name>A0A1W1I8G8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49290">
        <property type="protein sequence ID" value="SLM49290"/>
        <property type="gene ID" value="NSJP_3124"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3124"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012370788" evidence="1">
        <location>
            <begin position="28"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="226" mass="25061" checksum="53126A69EF3EA8E3" modified="2017-06-07" version="1">MTDFTLRHIALATLCLGALLSTLNVAAQDLNGRGPLHIVSDPAEITAFLPPSTHLMLEPSSIERFLDQLDERPPDWKTVYGQGHHDPGHDDRLFALNRERDRRREGNPALSWLVAFAWIGELSPFDPQLGGFPVALGPKFIPTRWGVVRFKAEEPPGNLVVVADEASAGILNAESGRTLPANINVLMTGRLVPDESLVYDFSHEEEGLGLIMPFVRVEQVHYVLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8L4</accession>
    <name>A0A1W1I8L4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_2966</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2966"/>
    <dbReference type="EnsemblBacteria" id="SLM49133">
        <property type="protein sequence ID" value="SLM49133"/>
        <property type="gene ID" value="NSJP_2966"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2966"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="245" mass="26764" checksum="9BB462700FACD672" modified="2017-06-07" version="1">MPSFFVAPDAVTPPTIRITGPLLRHLKDSLRLADGDGLTLTEEGIRRHRAEIIATTDRLIECRILDTTAAPLRSGPRLVLAQALLKGEKMDWVIQKATELGADRIVPIQTKNAVVKLHPDRVEHQRARWERIAVEAAQQSERWTVPTIAEPIALSKVAAAYPSAVKFVLAERSTETSLTTVTLPAGTDQTVLLSIGPEGGWDEDELRLMREQAYSAVSLGSRILRAETAAIATLSIVQSRLGELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8R9</accession>
    <name>A0A1W1I8R9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49390">
        <property type="protein sequence ID" value="SLM49390"/>
        <property type="gene ID" value="NSJP_3223"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3223"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="214" mass="24133" checksum="E8BB98570FA30AC7" modified="2017-06-07" version="1">MTRKSVILRITTPSSDRLAARSGRLAGWAACLACTAGLALLAGCVQETKPDELFQLKPESLRNRAMSIRTFDTSNELELLSASAAVLQDLGYQVEESVHEVGYFRAVKERSAREHGQDWQRVMFFFFSLGGAVIPVDLHQQLVANLVTKPLNPEGTKQQVRISFYRIVWKGDGQANRQYIPPGEQYMEMIHDPEIYQQFFAKLSKAVFLEAHDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8T1</accession>
    <name>A0A1W1I8T1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3228"/>
    <dbReference type="EnsemblBacteria" id="SLM49395">
        <property type="protein sequence ID" value="SLM49395"/>
        <property type="gene ID" value="NSJP_3228"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3228"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019993">
        <property type="entry name" value="RecB_nuclease_TM0106_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03491">
        <property type="entry name" value="TIGR03491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="2">
        <location>
            <begin position="322"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_12" evidence="1">
        <location>
            <begin position="929"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1135" mass="125785" checksum="E3515892AAF0FC29" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I931</accession>
    <name>A0A1W1I931_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDDEXK_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3357"/>
    <dbReference type="EnsemblBacteria" id="SLM49524">
        <property type="protein sequence ID" value="SLM49524"/>
        <property type="gene ID" value="NSJP_3357"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3357"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="1">
        <location>
            <begin position="755"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1068" mass="118520" checksum="A5D6D04AA0970030" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I937</accession>
    <name>A0A1W1I937_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49512">
        <property type="protein sequence ID" value="SLM49512"/>
        <property type="gene ID" value="NSJP_3345"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3345"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="62" mass="6857" checksum="110067D9D16DB864" modified="2017-06-07" version="1">MSEMSTRRIIDQIAYFLGIGASGDVPLFVVVESRNPVFVAHFWLEDHAAARALSVGARDIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I948</accession>
    <name>A0A1W1I948_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Murein lipoprotein (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49547">
        <property type="protein sequence ID" value="SLM49547"/>
        <property type="gene ID" value="NSJP_3380"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3380"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="142" mass="15287" checksum="8BF9D40794D96B85" modified="2017-06-07" version="1">MTLATRVMKHGVAILAVGCMLTLAGCDYWPPALQTQIEQLRSELQTVTAEKSQLQTQLASIAKVKDDLQVQVDDLSRANRDKSAMIANLQNSVTSLQERVHKTSKAGASKAVPAKAHAKAKPKTVVKTSAKKRPAAKATAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9E0</accession>
    <name>A0A1W1I9E0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49602">
        <property type="protein sequence ID" value="SLM49602"/>
        <property type="gene ID" value="NSJP_3435"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3435"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="83" mass="9152" checksum="4A96A693E8333337" modified="2017-06-07" version="1">MAFSIDKMPEHEDRLPFAFDAEITQRALIGGRAGKLTARTGADSGHGKDEKKNNCLACTIGVKMASSEDPPVRRSRHARYDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9H3</accession>
    <name>A0A1W1I9H3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49687">
        <property type="protein sequence ID" value="SLM49687"/>
        <property type="gene ID" value="NSJP_3520"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3520"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="306" mass="33089" checksum="1A7B51443FC67D17" modified="2017-06-07" version="1">MAGDTSDDFQKELVDLFVQEAQEWLQNIHVALDELQQGPAPERHEALIGILAGGVTNLGGSAATINLPEVEQASFAAIPFIEALKDPLKSFSVQDFLSLCKQLGQIHVALTHATGVSFEAQDTSESNEATQRTVSPEEFLQALCQLQSAQEDGNASERNIVRTMIDQMEAQITAGVQQVGVEAVRDYLQRLSDSEEAFLRALDKSMPGLTAQISSMAESAPGAELEPCLQGVASLRIEAQNLNAVLAASFFSGLHSLLSVSAQYHVRLAAVRVEAIAARLDVVRAIVHRWSDQRRMERAAIGQALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9N5</accession>
    <name>A0A1W1I9N5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiamine-phosphate synthase</fullName>
            <shortName evidence="8">TP synthase</shortName>
            <shortName evidence="8">TPS</shortName>
            <ecNumber evidence="8">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="8">TMP pyrophosphorylase</shortName>
            <shortName evidence="8">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">thiE</name>
        <name evidence="11" type="ORF">NSJP_3412</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 8 9">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8 9">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3412"/>
    <dbReference type="EnsemblBacteria" id="SLM49579">
        <property type="protein sequence ID" value="SLM49579"/>
        <property type="gene ID" value="NSJP_3412"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3412"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="10">
        <location>
            <begin position="13"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="8">
        <location>
            <begin position="43"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="191"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM49579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="212" mass="22658" checksum="AA4C377E3F7F1FE7" modified="2017-06-07" version="1">MAVTTRTHELSGLYIILDPSVRPDRPLGAILKAAAEGGAKLFQYRNKVSSMREQYGEALSLRKFAAELGVTFIVNDRCDLALAVDADGVHLGQDDLSYGDVRKILGRNKIIGLSTHKAEQVREADDLKPDYIGFGPIFKPASKQDHDPVVGMDGLKQVRALTTLPVFAIGGIQAEEVPAVMRAGADGIAVISAAVAAPDVQKAVERLISLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9T6</accession>
    <name>A0A1W1I9T6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="1">AGPR</shortName>
            <ecNumber evidence="1">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="1">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">argC</name>
        <name evidence="3" type="ORF">NSJP_3588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3588"/>
    <dbReference type="EnsemblBacteria" id="SLM49755">
        <property type="protein sequence ID" value="SLM49755"/>
        <property type="gene ID" value="NSJP_3588"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3588"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="2">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="354" mass="37873" checksum="2F5B3071EE5A475E" modified="2017-06-07" version="1">MKKIRVGIAGASGYAGAELLRLVALHPQLELATVTSEKSAGTAVGSVFPSLAGLVSHSFQSLAPETLLADADAVFLALPHTKSLDPVAACMKAGKPVVDLSADYRLKNPAVYEQWYQTPHRHAHLLKDAVYGLPELHRDAIAKARLVASPGCYPTAAILQLAPLFAHDLVQPDTIVIDAKSGISGAGRSPALLYHFPEAHESLEPYKIGQHRHIPEIEQELNALLPGNPASNKPASMVAFTPHLVPMNRGILSTAYCRLKHPAALADLRALYRTYYKGASFVRLSDDIVPNPRYIKGSNYCDIGVYADQRAGWVVTVAAVDNLVKGAAGQAIQAMNLMLALPEDMGLTAPAAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9U4</accession>
    <name>A0A1W1I9U4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3482"/>
    <dbReference type="EnsemblBacteria" id="SLM49649">
        <property type="protein sequence ID" value="SLM49649"/>
        <property type="gene ID" value="NSJP_3482"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3482"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="98"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="378" mass="42013" checksum="F88F46D72B880FEA" modified="2017-06-07" version="1">MRALRTAAHYAILLIGLSLVTILAAEGALRLSGYVSVASVHTVSAAEYDRVPGMFEPNQSLIEKPHPRLHYRVTINSLGYRGPEIDRRKSSDTVRILCIGDSGTYGEFVDDSDTLSVLLEQKLRKEGFQVEVVNGGVPGTTIVDQMQFVRRGMALDPDMVILTFSENDIGDLGAAVPQYVALERNRLLKSKPGFKLVYGLLRDTALFNYMLKVRAAWAIHARAPSQTVEISPAPDVEREVYESRWSLYADTLRKMQRFLADRRVRFLFNVYPTHQRIGVPTPMEPGQSSQVQRIQDLARSIGIPTVETLPWFVRSGYAKEELYHLPYDGHANGNGYRVQSAALLPAVRDYMAAASLDVGTAKRPGRTAELAGSPPLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA17</accession>
    <name>A0A1W1IA17_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49846">
        <property type="protein sequence ID" value="SLM49846"/>
        <property type="gene ID" value="NSJP_3679"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3679"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="56" mass="6050" checksum="888DD2278BE38D09" modified="2017-06-07" version="1">MRARKPGHSTSSDATGLLGIDSHGQRTPSFVWVFSFDMGISQSNTSGYPMPTMRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA38</accession>
    <name>A0A1W1IA38_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative oxidoreductase, Zn-dependent and NAD(P)-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yahK</name>
        <name evidence="5" type="ORF">NSJP_3699</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3699"/>
    <dbReference type="EnsemblBacteria" id="SLM49866">
        <property type="protein sequence ID" value="SLM49866"/>
        <property type="gene ID" value="NSJP_3699"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3699"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="26"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="366" mass="39454" checksum="C92599F9A7BBD40D" modified="2017-06-07" version="1">MTLPIEALQEHTAINMYKTKAYGAAAATSSMAALTIPRRDPGERDVQIDVLFCGICHSDLHQVRNEWKSVAPTVYPCVPGHEIVGRVAKVGTAVKKFKVGDLAAVGCLVDTDQTCHECQAGLEQFCGNLTLTYNSPDKHLGGVTYGGYAESIVVDHRFVLRIPPNLDLAGTAPLLCAGITTYSPMRHWGVTKGKKVGVVGLGGLGHMAVKFAHALGAHVVVFTTSPNKKDDALRLGADEVVISRDANEMKKQTGSFDFILDAVSADHDINVYIELLRRDGTITLVGAPEKPLAVAAFGLLFGRRSLSGSPIGGIPETQEMLDFCSAHHITSDVEVIPIQKVNEAYDRLLKSDVKYRFSIDMASLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA75</accession>
    <name>A0A1W1IA75_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3791"/>
    <dbReference type="EnsemblBacteria" id="SLM49958">
        <property type="protein sequence ID" value="SLM49958"/>
        <property type="gene ID" value="NSJP_3791"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3791"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011459">
        <property type="entry name" value="DUF1565"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07602">
        <property type="entry name" value="DUF1565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1565" evidence="1">
        <location>
            <begin position="48"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="213"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="441" mass="47039" checksum="AA96664234BCC02A" modified="2017-06-07" version="1">MTATLRIVCDHAVARVIILAIVYLGGCAPSDSSQSVSQSNGSVYYVATTGNDSNSGERTSPFQTIRHGISVLTSGDTLYIAGGTYAERLDSNESTIPSGSSWNKPVMIAAVPGQVVTMRPGAGPAVVNLAHPYIQYVIFDGIIFDGSNAESDVIGLNGGAHHVRFANGEIKNGKSNGVILSFNSNGATRFNEFINLKVHDNGYTNGVPDDNFHGFYITTDSNLIDGCEVYNNAGNGGKFYDTPSGNVFNNVVRNSIFHDNSKDLDPDRWSAGFFTSSGTGNQIYNNIAYNNYIGFAVLRGGNGNILYNNISYANEIAGINIDAANGSLTGAKVYNNTIVNNGRFGILLSNAPTDTAITNNIVYQNPTNISSDGTDKGMVLLTNLLIDPKFKNAASHDFSLQQGSPAIDTGTSLSEVTDDFARVRRPQGAQHDIGAYEYVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA80</accession>
    <name>A0A1W1IA80_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49900">
        <property type="protein sequence ID" value="SLM49900"/>
        <property type="gene ID" value="NSJP_3733"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3733"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="261" mass="29246" checksum="77214629084F33FA" modified="2017-06-07" version="1">MDTDPTKTLPSREELQAELLDVPEPPEQPEPVDEPGFEELVQLALRHAKGRRGGDLVSVILIGSGARRSVTAHSDIDLIALVKGQADAHEIVRVAARLADIRYYGHRDLEDELAYSPRLPPLLRKSRILFDHDAIGAKLIDRANQRFRQGPAPSSVNEQIRLKAQCLHWLGKAQDLADKPATANYLMMMFFDEYSNAFFRLKGLWLTPPADLLRFISSRDQSLGELVGKFLTAGTLPERLNIGRDLADLLFREVPNPARID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAA6</accession>
    <name>A0A1W1IAA6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49954">
        <property type="protein sequence ID" value="SLM49954"/>
        <property type="gene ID" value="NSJP_3787"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3787"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="96" mass="10224" checksum="5CD21020994FF7FD" modified="2017-06-07" version="1">MRDALLGILLVVILSIGLFAPQAEAAGSLPAWGSSGAMATWDSNSFLAWLASTLRNYIGNSQNNYPTKSVPVPGTLLFAAGGFIGLVLWRERKTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAE6</accession>
    <name>A0A1W1IAE6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exoribonuclease II</fullName>
            <ecNumber evidence="2">3.1.13.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rnb</name>
        <name evidence="2" type="ORF">NSJP_3724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.13.1" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3724"/>
    <dbReference type="EnsemblBacteria" id="SLM49891">
        <property type="protein sequence ID" value="SLM49891"/>
        <property type="gene ID" value="NSJP_3724"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3724"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040596">
        <property type="entry name" value="RNase_II_C_S1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18614">
        <property type="entry name" value="RNase_II_C_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="1">
        <location>
            <begin position="48"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="497" mass="55020" checksum="7FB169DB6213064E" modified="2017-06-07" version="1">MGTHRSDLRGIARRAMVERDFYPDFSPAALGELARISVPADGTGDPQVRNLIHWQWVSIDNDDSRDLDQLTVAEVAPDGLASIRVAIADVDALVAKDSSLDAHALHNTTSVYTSGGVFPMLPDKLSTDLTSLNERQDRLAIVVDMRVAEDGEVLDSRIYRAMVRNHAKLAYGSVGAWLEGTGPVPDAVKAVEGLDAQLRLQDRVARRLKARRHQEGALSLETLEPKAVFDGERLSTVLVERKNRAKDLIEDFMIAANQASVSFLKAEGLPSFRRVLRSPERWQRIAEVAARWNEALPAEPDARALEAFLVKRREADPLRFPDLSLAIVKLIGRGEYVLDRWQDGSSEHFGLAVRDYTHSTAPNRRFPDLITQRLIKAALANASLPYRPDELQFLADHCTRKEDDAEKVERQLRKSAAALLLESQIGRRFDAIVTGASNKGTWVRLLDPPVEGKLISHAGGLDVGDILPVELLHTDVEHGFIDFAPVGPAHNSNRSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAI1</accession>
    <name>A0A1W1IAI1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="4">6.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rtcB</name>
        <name evidence="5" type="ORF">NSJP_3890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3 4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RtcB family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3890"/>
    <dbReference type="EnsemblBacteria" id="SLM50057">
        <property type="protein sequence ID" value="SLM50057"/>
        <property type="gene ID" value="NSJP_3890"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3890"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="PTHR11118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01288">
        <property type="entry name" value="UPF0027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="1">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="206"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="335"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="380"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="406"/>
            <end position="409"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU371113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM50057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="483" mass="52594" checksum="6DFF1F23416B3EAF" modified="2017-06-07" version="1">MKLNTDMLINRITDEIWEIPVSEKSGMLVPARIYATETVLRSMDSGVFDQVTNVACLPGIQRYALCMPDGHWGYGFPIGGVAAFDVRNGVISPGGVGYDINCGMRLIRTDLTLDDVQPRLERLMTELFRRVPAGVGAGGFVRLNRPSFEEVMTKGARWCVEEGYGWHRDLAKIEEQGCIGGADPSKVTDRALARGINQLGTLGSGNHYLEVQVVSNGRVFDPDAAAALGITGHDQIVVMVHCGSRGFGHQVASDYLNVFEKAMRRYGVSVKDQQLACAPFRSEEGQDYFAAMNCAANTAFANRQVITHQIREAFAAVFGQSAEELGMELIYDVAHNIAKVERYAEGDLLVHRKGSTRAFGPGHPDLPEPFRKIGQPVICGGSMETGSYLLVGTDRAVRDTFGSTMHGSGRTMSRAQAKKSVRGEQLQQQMKQRGIVVKAVSMSGLAEEAGFAYKNISEVVETVDRAGITKKVAELRPIGNIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAJ2</accession>
    <name>A0A1W1IAJ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Multi-domain non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_3900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3900"/>
    <dbReference type="EnsemblBacteria" id="SLM50067">
        <property type="protein sequence ID" value="SLM50067"/>
        <property type="gene ID" value="NSJP_3900"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3900"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="990"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="8">
        <location>
            <begin position="1545"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2090"/>
            <end position="2165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1065"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2071"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="1025"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="2125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM50067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="2987" mass="332895" checksum="A35F93424ABCAA03" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAP5</accession>
    <name>A0A1W1IAP5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative FecR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3917</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3917"/>
    <dbReference type="EnsemblBacteria" id="SLM50084">
        <property type="protein sequence ID" value="SLM50084"/>
        <property type="gene ID" value="NSJP_3917"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3917"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032623">
        <property type="entry name" value="FecR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16220">
        <property type="entry name" value="DUF4880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4880" evidence="3">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="114"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="320" mass="35128" checksum="6704303B30DEA991" modified="2017-06-07" version="1">MRSDRTPALSRPMEQALDWFLRLKEAGVGESDRRAFDAWRAADPSHAGAYRAVVAMWESPEFTASVARHGQAACEVIEQRKTRPWKRYAAIAACALLAVGLMNLTAIRVAWQSDHRTGVGERERLSFSDGSTAVLNSGSAVALQFTPEARRVELLKGETYVDVSKDPRRTFELAGGEAVARVVGTGFSMRRESDASIVTVHHGEVAVRRSGEGQEEIHLHAGDLVRVTSRGMEPVRRVDPGDAFAWVEGRIRFHDQPLGDVLAELDRHHSGVILVTDPRLNAIRVSGNYRLDNPAAVVASLADATHARVVNISSYVIILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAP7</accession>
    <name>A0A1W1IAP7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Linear gramicidin dehydrogenase LgrE</fullName>
            <ecNumber evidence="3">1.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lgrE</name>
        <name evidence="3" type="ORF">NSJP_3903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3903"/>
    <dbReference type="EnsemblBacteria" id="SLM50070">
        <property type="protein sequence ID" value="SLM50070"/>
        <property type="gene ID" value="NSJP_3903"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3903"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="254" mass="28493" checksum="AC3D879C6F299976" modified="2017-06-07" version="1">MLTAARPSPWVVTHRPSPDGMRLICFPYAGAGASAFRSWPDGLPSDVEICAVQLPGRESRITEPPVADLRELVPRLSDALEPYLDRPFAFFGHSIGALVCFELARELRRARGLEPVHLFVSGCPAPHHPDSDRLSELSESEFVDRLKQFNGTPPEVLHHPELMQLVLPTLRADFSLRDRYLHRDEPPLGCPITAFGGMADGHVSGAKLEGWKRHSRERFQLWLFQGDHFFLRTAQEPMLEALSSLVSRCRGTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAT0</accession>
    <name>A0A1W1IAT0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Peptidase M48, Ste24p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_3990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3990"/>
    <dbReference type="EnsemblBacteria" id="SLM50157">
        <property type="protein sequence ID" value="SLM50157"/>
        <property type="gene ID" value="NSJP_3990"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3990"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="100"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM50157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="327" mass="35619" checksum="1BFEEC104541E27E" modified="2017-06-07" version="1">MGMLQAQGEEQLGTLVERALAAPVGRRTMLALGVRGAMGLYAALGMGAWSGLMGSLSGCYRAPGTARDQLIFFSEEKELEFGMSAYREVLRQARLSDDPEKNDLVQRVGKKIAEVTNKPEYQWEFALIDDDKMVNAFCLPGGKVAVFTGILKHTKNDAGMATVMGHEIAHALQRHGVERMSRSIIDQIAQLGALGAAASGHSSGAAIQGLLGAYGVNVSLPFNRKQESEADYIGLRLMAQAGYDPHEAVPFWERMSGCPRQMIDKLCFRSQHAIPEFLSTHPSDVTRMNQIEAWMPETMQYYHGATGKTTPAPAPYKPSIGPMPKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB10</accession>
    <name>A0A1W1IB10_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Polysaccharide export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_4070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4070"/>
    <dbReference type="EnsemblBacteria" id="SLM50237">
        <property type="protein sequence ID" value="SLM50237"/>
        <property type="gene ID" value="NSJP_4070"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4070"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012325547" evidence="2">
        <location>
            <begin position="26"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="134"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="226" mass="24337" checksum="80CE151675F77519" modified="2017-06-07" version="1">MRKTNVLGVYAVLLTLLTGMSVVSAQEVDPKKHGAASTKAAAPGAAEKSLLIVTPEYIIGPEDVLEITVWKNADLSKQVQVRPDGRISLPLLGDISAVAKTPTQLTEEISTGLRAYMENPTISIMIKDVQSYNIYVLGEVNKPGKFPLKSKTTLLQGITVAGGFTPMAARNKIVVFRFTKDGEGQTKLKASYDDIVVRDGSSQNIELKPGDQIVVPSETMVVLPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB20</accession>
    <name>A0A1W1IB20_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_4023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4023"/>
    <dbReference type="EnsemblBacteria" id="SLM50190">
        <property type="protein sequence ID" value="SLM50190"/>
        <property type="gene ID" value="NSJP_4023"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4023"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="18"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="371"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="681" mass="73764" checksum="26122E56C26DDC27" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB78</accession>
    <name>A0A1W1IB78_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized deoxyribonuclease YabD</fullName>
            <ecNumber evidence="1">3.1.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yabD</name>
        <name evidence="1" type="ORF">NSJP_4107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.21.-" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4107"/>
    <dbReference type="EnsemblBacteria" id="SLM50274">
        <property type="protein sequence ID" value="SLM50274"/>
        <property type="gene ID" value="NSJP_4107"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4107"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="259" mass="29126" checksum="639AF175A0282870" modified="2017-06-07" version="1">MLIDTHVHLDDPRFDADRDATVARAREAGVGTFVTIGCDLATSRAAVGLAGHYESVYASIGVHPHEVKHIDDGWYDEFRRLAAHPKVVAYGEIGLDYHYNHSSPQQQRDRFREQVRLARELRLPVIIHTREAQEDTVKILQEERASEIGGVFHCFSGDAWLAKDALELGFYLSFSGILTFNNASMLRDIAKQTPLDRLLIETDCPYLTPVPHRGKRNEPAYVSLVARQLAALHAEQAGLTLEDIERVTTDNAKRLFKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBF2</accession>
    <name>A0A1W1IBF2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to oligosaccharide deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nodB</name>
        <name evidence="2" type="ORF">NSJP_4052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50219">
        <property type="protein sequence ID" value="SLM50219"/>
        <property type="gene ID" value="NSJP_4052"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4052"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="27"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="242" mass="27640" checksum="61562932C340A38C" modified="2017-06-07" version="1">MRPVITQVKAEIKKILGSLTSVVTKDRVAALTFDDGPHPEFTPQVLDVLDRHRAQATFFMVGQAAKQYPDLVRRVGEAGHAIGGHSWDHSSFRRLTGSERRRQMLACQEALAPYGSPLVRPPYGEQSLAARLDAFRLGYEVVGWSFDVGDWYELDASLMANRLVEWLQPGSVVLLHDALFDQSKPASERKHERQSHADRKFMLKALDEALKRLSGRYHFVTVPELLRRGSPYRTFWFKKFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBK9</accession>
    <name>A0A1W1IBK9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAM hydrolase / SAM-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3986"/>
    <dbReference type="EnsemblBacteria" id="SLM50153">
        <property type="protein sequence ID" value="SLM50153"/>
        <property type="gene ID" value="NSJP_3986"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3986"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002747">
        <property type="entry name" value="SAM_Chlor/Fluor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023227">
        <property type="entry name" value="SAM_OH_AdoTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023228">
        <property type="entry name" value="SAM_OH_AdoTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35092">
        <property type="entry name" value="PTHR35092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01887">
        <property type="entry name" value="SAM_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006779">
        <property type="entry name" value="UCP006779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101852">
        <property type="entry name" value="SSF101852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102522">
        <property type="entry name" value="SSF102522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="270" mass="29860" checksum="035581B884F71A20" modified="2017-06-07" version="1">MPHPAGLITLLTDFGTADWFVASMKGVILSINPQATIVDLTHEIPPHAVGNAAYVLASCCRSFPTGTVHVAVVDPGVGSQRRPLIVQTARYFFLAPDNGLLSHALGQEENVEVREIENRRYRLEPLGRTFDGRDVFAPAAAWLTKKESLPSFGSLLQSYENLQVRMPQWEQREGRAALTGEVAYIDRFGNLITNLSADHVKQWQEATKRSRPVIQFSGHRIDGLVGSYREGERHRPHALINSGGYVEIFLSESNASVRLSVMNGEPVCLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBQ1</accession>
    <name>A0A1W1IBQ1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NGN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_4164</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4164"/>
    <dbReference type="EnsemblBacteria" id="SLM50331">
        <property type="protein sequence ID" value="SLM50331"/>
        <property type="gene ID" value="NSJP_4164"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4164"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NGN" evidence="4">
        <location>
            <begin position="15"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM50331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="177" mass="20099" checksum="6A635962C089CBA1" modified="2017-06-07" version="1">MSRMPSSAMDCETERSRWYALRTRSRHEKLVRDQLNGQGIEPLLPTVRRLSQWKDRKKEVEVPLFSGYCFVRFASEQKLPVLKTVGVVDIVGGGFQPEPIPDEEILALQTLMATVLPYDPHPYLHEGMAVEVIRGPLQGVRGILLRKEKRHRLILGIRLIQQAAAVEIDVDDIAPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBX4</accession>
    <name>A0A1W1IBX4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="5">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroF</name>
        <name evidence="7" type="ORF">NSJP_4106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4106"/>
    <dbReference type="EnsemblBacteria" id="SLM50273">
        <property type="protein sequence ID" value="SLM50273"/>
        <property type="gene ID" value="NSJP_4106"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4106"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DHAP_synth_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PTHR21225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="6">
        <location>
            <begin position="44"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM50273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="352" mass="38355" checksum="F4ABE3C6566D2ED8" modified="2017-06-07" version="1">MNRPLDNQHVIEIKALPSPRAIKTKLPITDHAGALVVETREAIRRILHGADRDRLVVIVGPCSIHDPDAAYEYADRLKVTADSLRDRLLIVMRTYFEKPRTTIGWKGLINDPHLDGTCDIAVGMELARTILLEINRRGLPCATELLDPISPQYIADLISWTAIGARTTESQTHREMASGVSMPVGFKNGTEGSLQVAVNAMISARTPHHFLGINADGQTSIIKTLGNPDRHIVLRGGGGKTNYDAEHVAKAETAVAGEGIARPIMIDCSHDNSSKDHRRQALVAREVVRQFQEGRSSIMGLMLESNLFPGKQTWQQGKALAHGVSITDACLGWGETEQLLGELADAIVAKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZX6</accession>
    <name>A0A1W1HZX6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Cytochrome c (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_0129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0129"/>
    <dbReference type="EnsemblBacteria" id="SLM46301">
        <property type="protein sequence ID" value="SLM46301"/>
        <property type="gene ID" value="NSJP_0129"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0129"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="52"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="186"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="591" mass="66447" checksum="9E80F0D423065A01" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I026</accession>
    <name>A0A1W1I026_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Biopolymer transport protein ExbD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">exbD</name>
        <name evidence="9" type="ORF">NSJP_0186</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0186"/>
    <dbReference type="EnsemblBacteria" id="SLM46358">
        <property type="protein sequence ID" value="SLM46358"/>
        <property type="gene ID" value="NSJP_0186"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0186"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="149" mass="16793" checksum="86A99BE6D7DB42F8" modified="2017-06-07" version="1">MFESRQRRFMAEINVIPLVDVVLVLLVIFMVTAPMLYRGMDIKLPTSATNTIKPEMRKVLTIEKDQRLYLDKDAVGVAQLEQKLKALKRDHPDVSLYLRADRDVPYGVVVQVMDGVKKAGIEKIGMVTDPTGPERVTETVTSGQPPRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I047</accession>
    <name>A0A1W1I047_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46378">
        <property type="protein sequence ID" value="SLM46378"/>
        <property type="gene ID" value="NSJP_0206"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0206"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="90" mass="9844" checksum="0BD482A6069B372D" modified="2017-06-07" version="1">MQFQRIKGANYAATQKKFVSLVSGLNVLFVLVLPGVRESRKQAGESSCLLHSLGHDTVEVYQLSRYIRPSTGLVVVLYRAAGFTNGGTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I080</accession>
    <name>A0A1W1I080_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Glycosyl transferase, family 9</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0127"/>
    <dbReference type="EnsemblBacteria" id="SLM46299">
        <property type="protein sequence ID" value="SLM46299"/>
        <property type="gene ID" value="NSJP_0127"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0127"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="343" mass="37731" checksum="801CD934C8427D78" modified="2017-06-07" version="1">MIRTVVIIHPGALGDVLLAVPAIVNLRRKFPRHEFVLCADRRIGELLRDCGLVDGWMPAQGFGVGQLFGGYVEAGSVMSNWLARCELAVAWVRDEGEILEEVLRRYVQGTVAVCSPFSPRLSSVHQSDRFWEALDEVARDSVQPVVLQLPRGLRELGRTRLREANLDPDRRIVLLHPGSGSRSKCAKAEIFAEVIHGLRRDGLGLALLEGPADHATVVEVSRLVREERIGILRDLNLGLLAGVLASADLFVGHDSGASHLSASVGTETITLFGPTVAERWAPRGGHVTVMKADACRCPNWEAVGHCVERPCLNIPPHTLLDMCRQRLVRHNSSKIHTKRLVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I097</accession>
    <name>A0A1W1I097_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Glycosyltransferase, group 1</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0230"/>
    <dbReference type="EnsemblBacteria" id="SLM46402">
        <property type="protein sequence ID" value="SLM46402"/>
        <property type="gene ID" value="NSJP_0230"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0230"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="395" mass="44076" checksum="3B7701D85A68173F" modified="2017-06-07" version="1">METVCHVITKLELGGAQEIALHLVSHLDPAKYRLVLATGPGGLLDEDAKAIRGLDVILLSWLGRPVHLFGDVAALVELIFLFRRLRPTIVHTHSSKAGILGRWAAWFAGVPIILHTIHGFGITPGQSPAVRWLFTRLERITGWITTYWIAVAQADIDRGRRWGLFEKNVSLIRPGIDPGPFELPFDERDRAAMRCEFGAGSDHWLIGTVACLKPQKAPEHFMAVAKNVCDRLPQARFVLIGDGELRQSVESLIVRYRLEDRVRLAGWRRDIPASMKAMDAFVLTSRWEGLPRVILEARATGLPIAATNVGGVREAMETHRSGIVVDDGDVAALSAFLVQLYREGRESRGHALKRAGSLPLEFHIDHMVYQYQTLYAELLEARRDDMQSQALGLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0B7</accession>
    <name>A0A1W1I0B7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46422">
        <property type="protein sequence ID" value="SLM46422"/>
        <property type="gene ID" value="NSJP_0251"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0251"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="170" mass="19471" checksum="F16D0B9304674545" modified="2017-06-07" version="1">MACSWLYRSNAESRRITADILFAGHRDQLFPLQSPFLRPANDHRRNPVGQGRMQTSCSPAFAEPSTHHVDDHAPEEPLLLDHDISKPDAIQILFPILVRIPAVIMWVCMDVEQKRDGHQQHTMRAQRPMYFSQDRQGLRNMLKQLRANNGIETLSQEGETRRIGLHVGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0C0</accession>
    <name>A0A1W1I0C0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 12 (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0245"/>
    <dbReference type="EnsemblBacteria" id="SLM46417">
        <property type="protein sequence ID" value="SLM46417"/>
        <property type="gene ID" value="NSJP_0245"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0245"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="94"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="252" mass="28662" checksum="8143D9F2568D4FCA" modified="2017-06-07" version="1">MIPQIHGLTRVAAALLKRLDTPALERLITGLAIERAATLPADESLRFLFRMQAALYPILGKTAVRYGGGVHTKHRHTKYHDFFVRRIRAHERVLDIGCGIGAVAFDIAERAGARVLGIDLVSGNIDAARRQHSHPRVEYRVQDGLASFGEQSFDVVVLSNILEHLSSRPEFLRGVSARVRPSRFLIRIPLFERDWQVPLKRELGVEWRLDDTHETEYTLESFDEEMRQAGCRITHQEVRWGEIWAEVTPDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0D5</accession>
    <name>A0A1W1I0D5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46465">
        <property type="protein sequence ID" value="SLM46465"/>
        <property type="gene ID" value="NSJP_0293"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0293"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="180" mass="19263" checksum="FF48202C418E7A65" modified="2017-06-07" version="1">MRSAAIAMGSKAAVTPSELSWRFIRWGLGLFITGFLTGFVPILHYMAGAQTGNVGADFLENVTLWWGCPAILAELTLKTGGLGMIAIGLVYLAITRQGESMTISSHESTAPMLCAYGLIATLVSAAAGFVICNYFWPNFYFQPVQAGKNAWLAAQGLSIVVYVIGLCYAFAGIRRAARPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0D7</accession>
    <name>A0A1W1I0D7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46470">
        <property type="protein sequence ID" value="SLM46470"/>
        <property type="gene ID" value="NSJP_0298"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0298"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="74" mass="8044" checksum="36A1A1406472FB27" modified="2017-06-07" version="1">MATDAPRLYDREGHYRGKLSTNTLDPDSINNPLGRYGSPLSPDSLNNPLGPGNALNPDSPRNRLGNGWRIEGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0D9</accession>
    <name>A0A1W1I0D9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PCP_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46313">
        <property type="protein sequence ID" value="SLM46313"/>
        <property type="gene ID" value="NSJP_0141"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0141"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.550">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013580">
        <property type="entry name" value="LI-POR_suB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042298">
        <property type="entry name" value="P-CP_red_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08369">
        <property type="entry name" value="PCP_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCP_red" evidence="1">
        <location>
            <begin position="109"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="166" mass="18802" checksum="52F8FD0FCE014D41" modified="2017-06-07" version="1">MLTCGCGRWMHSEGIEERVDDGASPQWFVRSECRGCGLRVGVEVPAGEPGGLIDRTMWTDDALHRLERMPPYLAELVREDVEQCLRAGNERVVTYDRLLGPLTGERIEWEPEAERRLDNVPSAVRAMAKIELERTAVERGDTRITVALMEEVKARYFGMGAAKDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0F8</accession>
    <name>A0A1W1I0F8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_0314</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MlaE permease family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0314"/>
    <dbReference type="EnsemblBacteria" id="SLM46486">
        <property type="protein sequence ID" value="SLM46486"/>
        <property type="gene ID" value="NSJP_0314"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0314"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Permease_MalE"/>
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        <property type="entry name" value="STAS_dom"/>
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    </dbReference>
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        <property type="entry name" value="MlaE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="197"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="8">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="385" mass="40373" checksum="BE855E0348EB627D" modified="2017-06-07" version="1">MAGEARVMASAETAQVVLQANSDADGGLVLFIDGPLDTHTTGRAWRIALDALSRSNPRRVIVDAARLTYCDGAGAALLLELQRRQLESRGSYEIRSLNAAAQSLLDLYGRSDRSSPESASPGWSSVEQIGRATVTLCRDVVALIAFVGELCAALGRAALRPGLVRWRDVFLTAELAGVNALPIVALLGFLLGLIMAFQSAIPMREFGADIYVANLIGLSMLRELGPLLTAIILAGRSGSAFAAELGTMKVSEELDALVTMGLEPVDFLVVPRVLAAVVMTPLLAIWAGFLGLIGGAVVMRSLGFPFVTYVIQVESAVTVSDMIGGLSKAFVFGIVVAAIGCLRGLQTRSGASAVGESTTRAVVSGLVLITIVDGVFAVVFYYLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0L0</accession>
    <name>A0A1W1I0L0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CASPASE_P20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0350"/>
    <dbReference type="EnsemblBacteria" id="SLM46522">
        <property type="protein sequence ID" value="SLM46522"/>
        <property type="gene ID" value="NSJP_0350"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0350"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025493">
        <property type="entry name" value="DUF4384"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14326">
        <property type="entry name" value="DUF4384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASPASE_P20" evidence="2">
        <location>
            <begin position="68"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="657" mass="72345" checksum="9636446A6EA64692" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0T6</accession>
    <name>A0A1W1I0T6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Diguanylate cyclase</fullName>
            <ecNumber evidence="3">2.7.7.65</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.65" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0422"/>
    <dbReference type="EnsemblBacteria" id="SLM46594">
        <property type="protein sequence ID" value="SLM46594"/>
        <property type="gene ID" value="NSJP_0422"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0422"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052621">
        <property type="term" value="F:diguanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="178"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="337" mass="36894" checksum="DBB59FAD1A0BBBF6" modified="2017-06-07" version="1">MSDTPLPSQYDPRVLLNSQPLIITVIDPLTHTVIFQNDSSRKKFGDISNATCHEKIAGCSTPCSFCRMPETVETGRPSSNEVPLPNDEHLLVQWAKVETTTGATHIVETITDITSLKRQQQETERLVTKLSATNRDLIQANQLLQDQSVRDSLTGLYNHSHFEQTLVHLCALALRSMRPLSLLFVDLDNFKQINDMYGHTTGDQVLREIGWLLDSQQGPSRGIARASDFAARYGGEEFALILPDTSMDGALSAAERLRHRVTTLTMLPELSALTMPSFALTCSVGVASFPIHADNPTDLVNAADTAVYAAKRAGKNRVRMAAPAPPPPSVPGPLVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Z8</accession>
    <name>A0A1W1I0Z8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46680">
        <property type="protein sequence ID" value="SLM46680"/>
        <property type="gene ID" value="NSJP_0508"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0508"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022265">
        <property type="entry name" value="CHP03790"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03790">
        <property type="entry name" value="TIGR03790"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="626" mass="69930" checksum="D2E33A178F75C150" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I116</accession>
    <name>A0A1W1I116_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Efflux transporter, membrane fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0523"/>
    <dbReference type="EnsemblBacteria" id="SLM46695">
        <property type="protein sequence ID" value="SLM46695"/>
        <property type="gene ID" value="NSJP_0523"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0523"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="2">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="478" mass="52967" checksum="3978FAC1C6BB5F54" modified="2017-06-07" version="1">MAGIAQTLRHKVRSIVNRPSGLDEMAIDDLAASNKLRAWEAVQIPERLKFSSKLALTLILLFILIIAFLPWTQTITVTGQLSAYTPFERPQDIEAQITGRIRKWHIFEGVRVRQGDLILELDDYDPNFMAPDLLVLLEQRRVALTETRKAALSRAGQLDKRIGEMQNIVKAAVPSAQARVVEAESKVREAYQKVEAAKIAVATAELNVDRHKQLAEQGLVSQRELEVAIQFAIASKADLTGTQANLKAAEQGMKALSFGRDQVNAEVLQRLLDAEAARDASIAEAARAADQLAEVSLRMSNAEQRRSASRILAPMDGTVVKMMQAGAGETVRQGDKIVRLSPTSADKAIEMTADGLDAPLLNVGRKVRILFYGIPAIPLPAWPDLMAGTFGGLIKVVDQVDDGKGNFRFWVVPDPDDRAWPPQEHVRQGTKAMGWVILNRVPLWYELWRRFNLFPPDYQERPPSLIDTLLPKAGRGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1C0</accession>
    <name>A0A1W1I1C0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46781">
        <property type="protein sequence ID" value="SLM46781"/>
        <property type="gene ID" value="NSJP_0609"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0609"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="130" mass="13791" checksum="6CBC4CE5BC2A72C3" modified="2017-06-07" version="1">MGNVAVVRKNYGEAELKLQGRIVYAWPNGIIEDGRDGSTGVAELAREANLASDILQQVVSQLGLLLTAAKGSEPIPADQVRVCLEEVLSELEESSTIHVLIQGACEAFNNAEPLPQVAARRKARANGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1E9</accession>
    <name>A0A1W1I1E9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative 3-hydroxydecyl-(Acyl carrier protein) dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0658"/>
    <dbReference type="EnsemblBacteria" id="SLM46830">
        <property type="protein sequence ID" value="SLM46830"/>
        <property type="gene ID" value="NSJP_0658"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0658"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="153" mass="16330" checksum="2AA2276DBA284009" modified="2017-06-07" version="1">MHPSVEGLIPHRGAMCLLDSVESWNEHTIVCRATSHRRPDHPLRCGADLYALCAIEYGSQAVAAHGSLLAGSVSAQDGRVLASVRDVVINVAVLDDLVEPLTVRAELVLAHDHGRIYDISVTAGSTTVLTGRIVVMAHPLAKEASPGESRVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1N4</accession>
    <name>A0A1W1I1N4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">(R)-citramalate synthase</fullName>
            <ecNumber evidence="4">2.3.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NSJP_0746</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19045"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30934"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.182"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from pyruvate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.182" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0746"/>
    <dbReference type="EnsemblBacteria" id="SLM46918">
        <property type="protein sequence ID" value="SLM46918"/>
        <property type="gene ID" value="NSJP_0746"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0746"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043714">
        <property type="term" value="F:(R)-citramalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005675">
        <property type="entry name" value="Citramal_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43538">
        <property type="entry name" value="PTHR43538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00977">
        <property type="entry name" value="citramal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="11">
        <location>
            <begin position="31"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM46918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="555" mass="60696" checksum="B7A5FF4E19C7C154" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1U9</accession>
    <name>A0A1W1I1U9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">polA</name>
        <name evidence="10" type="ORF">NSJP_0792</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0792"/>
    <dbReference type="EnsemblBacteria" id="SLM46964">
        <property type="protein sequence ID" value="SLM46964"/>
        <property type="gene ID" value="NSJP_0792"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0792"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
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        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="8">
        <location>
            <begin position="6"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="9">
        <location>
            <begin position="637"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM46964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="883" mass="97339" checksum="AA2C0956EC4B59C0" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I203</accession>
    <name>A0A1W1I203_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47025">
        <property type="protein sequence ID" value="SLM47025"/>
        <property type="gene ID" value="NSJP_0853"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0853"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="80" mass="8808" checksum="AEA79E02897028F2" modified="2017-06-07" version="1">MINPLIPFRSNNPIQERKMGLAAVTNQVQVCESMLEERAKHLNSSCFSITTSGSRPESGDRATDARNAGWFIGRSCIPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I294</accession>
    <name>A0A1W1I294_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Inositol-phosphate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.25" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0964"/>
    <dbReference type="EnsemblBacteria" id="SLM47136">
        <property type="protein sequence ID" value="SLM47136"/>
        <property type="gene ID" value="NSJP_0964"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0964"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="270" mass="29646" checksum="7B7C1865E390F992" modified="2017-06-07" version="1">MVSCMDRELNLLVESVREAGARVLELARLGFDVQTKSDRSPVTTADLEVNRILHAMQQKYFPEDGWLSEESPDDPARLERARVWIVDPIDGTRAFIRKLPEFCISVALIEKGHPLASVIFNPSTDELFSAARGRGLRVNGKPVVPRSIGTDSPLVMVSPGEFRSGRWTELNQRARTSTFHSIAHALTLVATGRAQAAITAETENEWDLAAGVLLIEEAGGLVEDADHRSLTFNQPVPQFTGLLALAGTTDPHLQPLLRSHVARAGKRATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2T3</accession>
    <name>A0A1W1I2T3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47302">
        <property type="protein sequence ID" value="SLM47302"/>
        <property type="gene ID" value="NSJP_1130"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1130"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="26" mass="2723" checksum="54D279CD43C6872C" modified="2017-06-07" version="1">MLPLSLYPVGDVDPAGKTPGTPRDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2V4</accession>
    <name>A0A1W1I2V4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Cyclic nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1174"/>
    <dbReference type="EnsemblBacteria" id="SLM47346">
        <property type="protein sequence ID" value="SLM47346"/>
        <property type="gene ID" value="NSJP_1174"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1174"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH crp-type" evidence="2">
        <location>
            <begin position="159"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="254" mass="28646" checksum="F098925F30318F29" modified="2017-06-07" version="1">MPTQTDVEMERMDRSMEQDRVEGRNAILGALPEEEWQLVRERCQRVSFHEGKILQPAGAPCEWLFFPTGAALSLMAVTQEGLSIETGLIGQEGMVGLRQLFGYQNQSLECMVQHGGTVCQLSLSWLRRASLPVFHELVLRYAGYRLGELAQTSICNRFHLVRQRLSRWLLTAGDRTGKQELEFTQEMLSAMVGARRPVVTSLIGRMQSEGLIEYRRGCLIIQDRSGLETASCECYAILCDALAEYLRGLPSRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2W4</accession>
    <name>A0A1W1I2W4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_1047</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1047"/>
    <dbReference type="EnsemblBacteria" id="SLM47219">
        <property type="protein sequence ID" value="SLM47219"/>
        <property type="gene ID" value="NSJP_1047"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1047"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="PTHR31585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="543" mass="59427" checksum="A8EE4E8110D9F16C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2X4</accession>
    <name>A0A1W1I2X4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-homologous end joining protein Ku</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">ku</name>
        <name evidence="5" type="ORF">NSJP_1194</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Interacts with LigD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic Ku family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1194"/>
    <dbReference type="EnsemblBacteria" id="SLM47366">
        <property type="protein sequence ID" value="SLM47366"/>
        <property type="gene ID" value="NSJP_1194"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1194"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00789">
        <property type="entry name" value="KU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01875">
        <property type="entry name" value="Prokaryotic_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="Ku70/Ku80_beta-barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009187">
        <property type="entry name" value="Prok_Ku"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41251">
        <property type="entry name" value="PTHR41251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006493">
        <property type="entry name" value="Prok_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SSF100939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02772">
        <property type="entry name" value="Ku_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="4">
        <location>
            <begin position="82"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="317" mass="35366" checksum="F429BFFF77288DB8" modified="2017-06-07" version="1">MPRTRRNRAGAHRPAHPDGTADHTDNEASASRVLWKGAISFGLVHIPVGLYSAENRSSFDLTMLDRRSMHPVGFKRYNKDSGEDVPWNDIVKGYEYEKGRYVVLTDEDFRRANIEATQTVEIVNFVPQEAISPLYFDTPYYLAPDKRGEKGYVLLRETLKQTGKVAIANVVIRTRQHVAALLPVGSVIVMNTLRYPNELRPSDELDIPSGNLKAVGVNAREIDMARRLVDEMSEDWKPETYRDTYHGDLLALIEKRVQAGQTEAVEQPAVEEEQPSPKGEVIDLMALLKRSVETRGKSGKPAGPSGSRGRKAGRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I363</accession>
    <name>A0A1W1I363_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47447">
        <property type="protein sequence ID" value="SLM47447"/>
        <property type="gene ID" value="NSJP_1275"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1275"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="198" mass="22826" checksum="A0A359BC60CE91BA" modified="2017-06-07" version="1">MTGDVFSRGSMKLFLLIFLTAVLQGCEFWDKEIVDVYAPDSRRDKQREFYIQSLNYHLGKPKADRIRAIGPPDQCRNQNSTTEICEWTQVGQPLEHTVTYTYGRDGLATAWSYRGSYGEFTNANYETAKSAASIPGKNRNEAARPQEENWVHPSKTSVQFDEDNVQCRTEVQGYPKSMWDTESDKCLRRHGWTRVQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I390</accession>
    <name>A0A1W1I390_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative NADH-quinone oxidoreductase, subunit G</fullName>
            <ecNumber evidence="13">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NSJP_1305</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="13"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1305"/>
    <dbReference type="EnsemblBacteria" id="SLM47477">
        <property type="protein sequence ID" value="SLM47477"/>
        <property type="gene ID" value="NSJP_1305"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1305"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
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    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="14"/>
            <end position="92"/>
        </location>
    </feature>
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        <location>
            <begin position="92"/>
            <end position="131"/>
        </location>
    </feature>
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        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
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        <location>
            <begin position="228"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
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        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
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            <position position="280"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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            <dbReference type="PROSITE" id="PS51379"/>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SLM47477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="895" mass="97458" checksum="5E8AD6627560331D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3A0</accession>
    <name>A0A1W1I3A0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
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        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SLM47464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="102" mass="11083" checksum="C6DE47D98B6CFE62" modified="2017-06-07" version="1">MKFRSSLACILLLCLAGCADGARLVQNDDSGGVVVYPFKGDQGAVLSSFRKDALTLIKEKCGGPYTIVREGEAKGRARIAGAVEGSQEMVRERRWGIEFRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3B8</accession>
    <name>A0A1W1I3B8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000192042">
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    </dbReference>
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    <dbReference type="Pfam" id="PF07238">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="60"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="171" mass="18789" checksum="B8104AFC4AC25155" modified="2017-06-07" version="1">MKFPVTMTAGHDGAILEVDADQESISLHDQHGELLGTLSWQEIIERIVATDDAQRFAHARAHARAPLAVKVRYTTPEGKQYDSLTGGIGGGGLFIESSTPLAPGTELAVEFTLPDRPWAKHTAKAKVAWTRNKPERFLLFPGMGVQFTDIDDQARKELVELVAALNRSRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3G7</accession>
    <name>A0A1W1I3G7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
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        <lineage>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="SLM47429"/>
        <property type="gene ID" value="NSJP_1257"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1257"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="931" mass="102428" checksum="CA3B5CFD1BA2A077" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3H1</accession>
    <name>A0A1W1I3H1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative Uncharacterized ABC-type transport system, permease component YbbP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NSJP_1395</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
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            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1395"/>
    <dbReference type="EnsemblBacteria" id="SLM47567">
        <property type="protein sequence ID" value="SLM47567"/>
        <property type="gene ID" value="NSJP_1395"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1395"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="783"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="804"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="849"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="24"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="791"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="886" mass="96091" checksum="6BD2AF698D92D14D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3H3</accession>
    <name>A0A1W1I3H3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aminomethyltransferase</fullName>
            <ecNumber evidence="3 7">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">gcvT</name>
        <name evidence="10" type="ORF">NSJP_1370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3 7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1370"/>
    <dbReference type="EnsemblBacteria" id="SLM47542">
        <property type="protein sequence ID" value="SLM47542"/>
        <property type="gene ID" value="NSJP_1370"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1370"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00259">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022903">
        <property type="entry name" value="GCS_T_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="8">
        <location>
            <begin position="6"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="9">
        <location>
            <begin position="282"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="368" mass="40177" checksum="5011FC2214E5F4FE" modified="2017-06-07" version="1">MNRTPLYETHREAGAKLVDFAGWDMPIQYGSVIEEYQTVRSKAGLFDVSHMGRLYLSGTGSGSFLQRMTTNDVAKLAVGRAQYSMMCREDGGILDDVFVYRTGESDFLLCVNASNRKKIVDWINRQHRATDQCTIEDRSSAVAQIAVQGPSSRTVLARLCKKDLGALKLHASHEDLVAGIPCFVARTGYTGELGFELNMPSDRAAELWRNLMEAGTDQGIKPAGLGARDLLRLEMGYLLYGNDINEQTTPLEAGAEWTVNFEKGPFLGRDALLTQKHDGVRRRVIAFELIEKGVPRHGFPILDPASSEPIGEVTSGNLSPLLQKGIGLGCVPVSHSSPGTAIAVDIRGKILPASIVTAPFYTRPKPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3I9</accession>
    <name>A0A1W1I3I9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47587">
        <property type="protein sequence ID" value="SLM47587"/>
        <property type="gene ID" value="NSJP_1415"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1415"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35024">
        <property type="entry name" value="PTHR35024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="132" mass="14112" checksum="3FA84AB09DD73CA6" modified="2017-06-07" version="1">MWALKERQNPVVQGHDNITLFAKDVRFKGVVKFDGTVRVDGYVEGEIHTTGMLIVGETAVIKGVVSAGILMNSGRINGSITAAEKISVHKPGILVGDIRTPLIAIEEGSHFHGMCDMGLESRPDESAVTLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Q8</accession>
    <name>A0A1W1I3Q8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1466"/>
    <dbReference type="EnsemblBacteria" id="SLM47638">
        <property type="protein sequence ID" value="SLM47638"/>
        <property type="gene ID" value="NSJP_1466"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1466"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.550">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013580">
        <property type="entry name" value="LI-POR_suB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042298">
        <property type="entry name" value="P-CP_red_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08369">
        <property type="entry name" value="PCP_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCP_red" evidence="2">
        <location>
            <begin position="147"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="PCP_red" evidence="2">
        <location>
            <begin position="200"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="251" mass="26921" checksum="6D05203136017B52" modified="2017-06-07" version="1">MKFVCLNCETYMNFEKVEKPGEGSLGVFFGCPSCGAKFSMVTNPGETQMVSSLGVKLGGRTVAAEPFEMTRGTLKDEALAGSGQMAAYLNEKIQGGQPASAAPAATPKSGDKAGSSGCPFSAMVAEMGLTSSGKPANGAPAASEFTWTADAKEKLDRLPVFVKPMVQSSVEAYARKQGYTTITLQVMDDSKNDSPNGIAWTREAEQRLDNIPDFIRPMARKEIERLAKERGVPTITAQVMDDAKDKFMKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3S8</accession>
    <name>A0A1W1I3S8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47658">
        <property type="protein sequence ID" value="SLM47658"/>
        <property type="gene ID" value="NSJP_1486"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1486"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="40" mass="4390" checksum="7F5B608C4F4B94EA" modified="2017-06-07" version="1">MNDLAIAPQSQRDTANPRLSVTLADGLWRVKQTPDLIARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3V2</accession>
    <name>A0A1W1I3V2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47680">
        <property type="protein sequence ID" value="SLM47680"/>
        <property type="gene ID" value="NSJP_1508"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1508"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="123" mass="13836" checksum="AEE84889ECA06BA1" modified="2017-06-07" version="1">MRPVTQYARLSVSGSTKRREIGAEPSSDMGAPPFSATTWATHAHRYLNKRGRNADGRACKLTMRYTCHVRQKTLITDDLSSGSTLSMQAKPGLPVSGRYSYTGGDWDIWLAWERGRRECELVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Y9</accession>
    <name>A0A1W1I3Y9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1565"/>
    <dbReference type="EnsemblBacteria" id="SLM47737">
        <property type="protein sequence ID" value="SLM47737"/>
        <property type="gene ID" value="NSJP_1565"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1565"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="154" mass="17667" checksum="6C944C837C62DC3A" modified="2017-06-07" version="1">MVMELPNPKDDPHLRVLRPLVETYLAFWRIDSRHIRTMRLTPSQFDVIATLGDTDGMTCSELSARTLVTKGTLTGVLDRLVKKGLIRREQVVQDRRSIKITLTDKGTVLFRKTFAAHIAFLRPYFERALNSEEAETARVLLTRLRDSFDQPVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I409</accession>
    <name>A0A1W1I409_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47740">
        <property type="protein sequence ID" value="SLM47740"/>
        <property type="gene ID" value="NSJP_1568"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1568"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010717156" evidence="1">
        <location>
            <begin position="31"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="210" mass="23525" checksum="2530E147E5A0AEDA" modified="2017-06-07" version="1">MLAQRLRCTRPAAPVVIFLAVTAAFTSAQATPAIDDSIFPRFSRHVIRYVQRDKVAFAQASTCLSWFYKGTKTPPPVVQGIHWQPSAFSKPEKDCPAIYPKGMDAARDDFAKTQAQLSIGLTVYELALVADRNDDYTYNATELRDLFASLSLTLDPSDPTQGPVATLTERFDRWYQVRSLDEVMTGMSLLYDQGYRVTAGDRADLDRIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I417</accession>
    <name>A0A1W1I417_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47744">
        <property type="protein sequence ID" value="SLM47744"/>
        <property type="gene ID" value="NSJP_1572"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1572"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="123" mass="13640" checksum="BC7327FC5F1F15E8" modified="2017-06-07" version="1">MKLCPSCRRELPELNRYCTQCGQRLDAYSFQDQPPAAAKPVAPQDTPESLNLRALYSMVAALILAVIFPPWEAPPSQEPEFLGLRFMLDPPAPDAIVSRLLLTIELVTIAIAGLYGAFLLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I429</accession>
    <name>A0A1W1I429_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47768">
        <property type="protein sequence ID" value="SLM47768"/>
        <property type="gene ID" value="NSJP_1596"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1596"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="40" mass="4458" checksum="2C3D838AE8CB2651" modified="2017-06-07" version="1">MKQLTRCLDLVIGPMRGTQSGSLHKDRIEPASRDKLSTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I460</accession>
    <name>A0A1W1I460_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_1635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1635"/>
    <dbReference type="EnsemblBacteria" id="SLM47807">
        <property type="protein sequence ID" value="SLM47807"/>
        <property type="gene ID" value="NSJP_1635"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1635"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PTHR12049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="407" mass="44887" checksum="0D2232CC086636EE" modified="2017-06-07" version="1">MTTTGHPQLTAAIVSEIEAAGPMPFVRFMDLALYHPQYGYYMRPPEAGTERIGWSGDFYTSSDVHPILGQALAKQAEQIDAFLGYPDPFTVVEMGPGKGLLAKHFLSACHARGSGTLQRRLRYVLIERSPAMRAIQQQHLQPWLERDGLVSWLEDIDSLPHDGTVGLLFSNELIDAFPVHRVEVSGGVLKECFVDYRDGRFVECLLPLSNPALAEYLTRLGLILPDGYRTEINLRARDWMASVAGSLSRGAVLTIDYGHSAQDLYGPDRARGTLLCYRSQLTSEDPYTMVGLQDMTTHVDFTSLALAGQEAGLSLTGFTNQMSFLMGLGVEEMIGRLEPESPEFFAALHLLQPHGMGRTFKILVQHKAMTDPQLDGLTFKPFFGSALTATSRGHHEAASAETVGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4B4</accession>
    <name>A0A1W1I4B4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyhypusine synthase</fullName>
            <ecNumber evidence="2">2.5.1.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1672"/>
    <dbReference type="EnsemblBacteria" id="SLM47844">
        <property type="protein sequence ID" value="SLM47844"/>
        <property type="gene ID" value="NSJP_1672"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1672"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008612">
        <property type="term" value="P:peptidyl-lysine modification to peptidyl-hypusine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="PTHR11703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="325" mass="37033" checksum="93F3F51FA7532B8A" modified="2017-06-07" version="1">MKATSVSQFIHVHYRHFNAASLRDASKGYMSHLDRGGQMLVTLAGAMSTAELGLSLSEMIRRDKVHAICCTGANLEEDVFNLVAHNHYERIPHYRELSAHDEQSLLKRHLNRVTDTCIPEEEAMRRVERAVFEEWALAERRGERRFPHEFLYRLLRQETLKAHYQIDPQDSWLYAAAEKDLPMFVPGWEDSTLGNIYAAHCMTKKLRNVHTVRTGVEYMMELAEWYGRVTATQSIGFFQVGGGIAGDFPICVVPMLSQDLRKENVALWGYFCQISDSTTSYGSYSGAVPNEKITWGKLGAETPKFIIESDATIVAPLMFAYVLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4C7</accession>
    <name>A0A1W1I4C7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47856">
        <property type="protein sequence ID" value="SLM47856"/>
        <property type="gene ID" value="NSJP_1684"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1684"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="85" mass="9178" checksum="5F8080CE57FB450B" modified="2017-06-07" version="1">MLEPHEGGPIHLKRARILAPSTYILLGAGVAVTGCPVARSGRDPLGDGWSEHQGAGCRDRTRAHTPFIALYDDSIMIPGELDRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4F7</accession>
    <name>A0A1W1I4F7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_1718</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1718"/>
    <dbReference type="EnsemblBacteria" id="SLM47890">
        <property type="protein sequence ID" value="SLM47890"/>
        <property type="gene ID" value="NSJP_1718"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1718"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="329" mass="36114" checksum="82602E773E6F4FE0" modified="2017-06-07" version="1">MVKRLLLAVGLFTLGFLVWYIGPAEIYDAVHRLGPVAILAILAPSFIMYLVEGYGWKVTLERPERVPFWRLLMIRMAGEVVNMTTPTAYVGGEPLKAYLLQRHGVPMVEGLASVVIAKTTMTIAQVLFIIVGIGVGLWILGPDGSPGQIITAALLSLGLLLFGTGAFVLVQRRGLFTWTLELIRKLGWRIAFLERREEQLRSLDRTILNFYTRRRGMFYLSTGLYLLGWLAEAIEVYVIIYCLGGSADMLSAVSIGALSVLIKGGTFFIPGSLGAQDAGNLLLLRAFGYSEVVGVAFALLRRFRELVWISVGLLCLTLIGKPQGSANDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4G2</accession>
    <name>A0A1W1I4G2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47759">
        <property type="protein sequence ID" value="SLM47759"/>
        <property type="gene ID" value="NSJP_1587"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1587"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="121" mass="13429" checksum="BCF52320BE176570" modified="2017-06-07" version="1">MGAPMSVPSVQDERSLGNAMMASVPEKRRQLPPRKVRLTVNLPQDLVEQVRDAVFWTPGLTIAWLIARAMRISLADMHSTNHGPFPRRSRPLRAGRPKLTGQTMNLQMSGKALPVGPLDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4K0</accession>
    <name>A0A1W1I4K0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DNA polymerase IV</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1760"/>
    <dbReference type="EnsemblBacteria" id="SLM47932">
        <property type="protein sequence ID" value="SLM47932"/>
        <property type="gene ID" value="NSJP_1760"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1760"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="2">
        <location>
            <begin position="5"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="397" mass="44046" checksum="4DC3515C725348FC" modified="2017-06-07" version="1">MDRHIAYVQIPCFGIALAQATDPVLRNRPVVLAPLHTPRALVLEASREAMQEGVRPGIPIELARRLCPNLRLIPPDLPSMRAAHRSVQRTVLPFAPAWESIGLGALFLDLTGTARCFGPPIDTVSRLGRALTRQQGLQTVIGLAGSKLVSQLAATSLTASPHILSIQAGSEQSFLAPLPAAWLPGLQHHARHVRASHILQRLEDLNLKTMGAVSSVPLVHLQSAFGAAATWLHDWASGVDPSPVRSPADQPAIEQSLGLNPDEIDDDRLLKRLYVLLENLCATLRQQGRVCRRLQLLVRHSDHQHQLAQQRLHHATCWEADLQPVLRRLFIRCFRRRVRLQHVTLQVDQLESPIDQLELFETWPASTPPVHQRLSLAVDRIRAKFGVQAVSWGAVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4K3</accession>
    <name>A0A1W1I4K3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1637"/>
    <dbReference type="EnsemblBacteria" id="SLM47809">
        <property type="protein sequence ID" value="SLM47809"/>
        <property type="gene ID" value="NSJP_1637"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1637"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="32"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="133" mass="14841" checksum="FDF53D85945773D8" modified="2017-06-07" version="1">MKGYIVQLEDATRKNENYRQVLFTARHSQLVLMSLKPGEEIGEEVHDLDQFIRFEAGEGTVILDGESHAVTDGHAVVIPAGTRHNVVNRSKQGLLKLYSVYSPPEHKSGTVHRTKKEADADEHHHFDGKTSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4N3</accession>
    <name>A0A1W1I4N3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47964">
        <property type="protein sequence ID" value="SLM47964"/>
        <property type="gene ID" value="NSJP_1792"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1792"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="82" mass="9396" checksum="A6329B3E781C7AF2" modified="2017-06-07" version="1">MTDEILKAYKEVELAVERYTRLLQDHAQMLQNMEPPGSDKVVRMTQGSKAMRDSAMIYLSYAKYVAYGMPASEEMIEDEIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I506</accession>
    <name>A0A1W1I506_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48098">
        <property type="protein sequence ID" value="SLM48098"/>
        <property type="gene ID" value="NSJP_1926"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1926"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="44" mass="4947" checksum="614B9ECCE8194FE3" modified="2017-06-07" version="1">MTSVSTQYFSPRTQRTIATEGTNREGHEEALPDELSNAKLSMFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I515</accession>
    <name>A0A1W1I515_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48075">
        <property type="protein sequence ID" value="SLM48075"/>
        <property type="gene ID" value="NSJP_1903"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1903"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="83" mass="9201" checksum="7E9DAE3D1B550664" modified="2017-06-07" version="1">MTIGIIYSYTPEVLAVVKRMDSCFEDLGHKVETNYKNGINPEAGWVLQVCAMLKKCDVVLRCIIMSTMSNRLIVGSGEVCVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I529</accession>
    <name>A0A1W1I529_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48102">
        <property type="protein sequence ID" value="SLM48102"/>
        <property type="gene ID" value="NSJP_1930"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1930"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="114" mass="12792" checksum="4AF32C8A2655F298" modified="2017-06-07" version="1">MNLKRKLQRQMLQALKDFYPAPNPNFAQQFESDPDYIGNLHYLNGHGLLTWTEYREGGAALPPQLLDFKITLAGLDFLEGDGGLGAILRTVTVKLEAHQLRQIVAAKKGKRSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I564</accession>
    <name>A0A1W1I564_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1985"/>
    <dbReference type="EnsemblBacteria" id="SLM48157">
        <property type="protein sequence ID" value="SLM48157"/>
        <property type="gene ID" value="NSJP_1985"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1985"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="494" mass="56068" checksum="D352D77377C3C6C8" modified="2017-06-07" version="1">MLNRIFGLETEYGLLVHQDRPDHSPTWFAHKIRDHLFNVRRQGVLDVHHRGHDEPPGNGGFLTNAGRVYLDMGHLEYASPECHSLTDVIAADRAGDTILQDTIEDLGFADQVSLIKNNVDHETDATFGSHENYLVSRRFPFTRRGLAPLVTFLVTRQIFTGSGRVGSAGPQDAWIQRDRLIVPRMSIGGGRLDPAAPFQISQRADHIVNDFFEWVQQNRAIVNTRDEPLADPNQYRRIHLLLGDSNMAEYAAALKMGTTGLILQLIEEGHIPDDLEIDEPVEALQEISQDQDRQWIVQLRSGKTMSAIDVQEQFVEAARQHCRGQDEETDWVIDQWSGVLQDLRGEYANLVGRVDWASKLWLLESFREAEKVDWTDPILKSLDLEYHNLNAGKGLYFGLLDEGRVTRVTTDKAIELAAAHPPRNTRAYGRGELVRHLLRNAPPSHESDSGQEERFFPPYVINWSIFQVRGQSPFPMPDPFKTYVQEVHAHLEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I583</accession>
    <name>A0A1W1I583_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c biogenesis protein CcsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ccsA</name>
        <name evidence="8" type="ORF">NSJP_1821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1821"/>
    <dbReference type="EnsemblBacteria" id="SLM47993">
        <property type="protein sequence ID" value="SLM47993"/>
        <property type="gene ID" value="NSJP_1821"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1821"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017562">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03144">
        <property type="entry name" value="cytochr_II_ccsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="7">
        <location>
            <begin position="92"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="304" mass="34290" checksum="C07F2082820498B9" modified="2017-06-07" version="1">MVRSLFLFDMTFWLYLAALTLYVAYLFARRPAMALAPAGHPSEDFEERDGAWATQLGQVATLVTIFGWLVNTGALLTRAFERLEHSGTFAPWSNQFEAMAYVSWAIILGYVLLEVRYKIKAIGAFVVGIGFIAMGAASLLPYRYQTAEPLVPALNSYWIYIHVSVTLTSYAAFAMAGGLGLMYLFKERAELRGSQSRFYAAFPELETIDELGYKAIMIGFPLLAFGIILGAMWANYAWGGYWSWDPKETWSLIVWLIYGAYIHARMTRGWEGRRAAIYAVFGFLMVIFCFWGVNFLLSGLHAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5A1</accession>
    <name>A0A1W1I5A1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="13">ATP-PRT</shortName>
            <shortName evidence="13">ATP-PRTase</shortName>
            <ecNumber evidence="5 13">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">hisG</name>
        <name evidence="16" type="ORF">NSJP_2004</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heteromultimer composed of HisG and HisZ subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">Lacks the C-terminal regulatory region which is replaced by HisZ.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the ATP phosphoribosyltransferase family. Short subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5 13"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2004"/>
    <dbReference type="EnsemblBacteria" id="SLM48176">
        <property type="protein sequence ID" value="SLM48176"/>
        <property type="gene ID" value="NSJP_2004"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2004"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13595">
        <property type="entry name" value="PBP2_HisGs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01018">
        <property type="entry name" value="HisG_Short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024893">
        <property type="entry name" value="ATP_PRibTrfase_HisG_short"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="15">
        <location>
            <begin position="51"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SLM48176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="233" mass="25497" checksum="F53351CE9DD66626" modified="2017-06-07" version="1">MLTVALCKGKLIEPALALFGRAGYAGARLATESRRLVFACPEIGMTFLIVRPTDVPTYVEHGAADVGIVGKDVLLEQDSDVYEPLDLGFGACRIAVAALRGQDSRDRLSSKIRVATKYPRITERYFNQRGVPVEIIKLYGSIELAPLVGLADRIVDLVETGNTLKTHDLVEVECIATSTARLIVNRASLKLKHATVTELIQKLRRAAMTRRPSTSVTANGRNRSNQKTKRVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5D4</accession>
    <name>A0A1W1I5D4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cation efflux system protein CzcA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">czcA</name>
        <name evidence="4" type="ORF">NSJP_2055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2055"/>
    <dbReference type="EnsemblBacteria" id="SLM48227">
        <property type="protein sequence ID" value="SLM48227"/>
        <property type="gene ID" value="NSJP_2055"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2055"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004763">
        <property type="entry name" value="CzcA/CusA/SilA/NccA/HelA/CnrA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00914">
        <property type="entry name" value="2A0601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="874"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="899"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="932"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="973"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1077" mass="117456" checksum="7B826AA435B3A6EB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5F2</accession>
    <name>A0A1W1I5F2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multidrug efflux system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sugE</name>
        <name evidence="6" type="ORF">NSJP_2054</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2054"/>
    <dbReference type="EnsemblBacteria" id="SLM48226">
        <property type="protein sequence ID" value="SLM48226"/>
        <property type="gene ID" value="NSJP_2054"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2054"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="104" mass="11237" checksum="2B82160692FEE412" modified="2017-06-07" version="1">MAWVYLIIAGCFEITWAVGMKYTEGFTRLWPSIWTALAMIVSLWCLAIALRTIPIGTGYAVWTGIGAAGTAIMGMVLFDESSDLMRLLSIAFIVAGIVGLKLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5H9</accession>
    <name>A0A1W1I5H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized transporter yedA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2063"/>
    <dbReference type="EnsemblBacteria" id="SLM48235">
        <property type="protein sequence ID" value="SLM48235"/>
        <property type="gene ID" value="NSJP_2063"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2063"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="166"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="314" mass="32579" checksum="69C9A69CBBCD882B" modified="2017-06-07" version="1">MTTDEKGCIPLSMSNSSVGLAYGAIVSAAVLWGGSIVAQKLALSGFSAVEASVLRDIGGLVILLATWWWQERSLAGLTTADVRILLGLGLGVLGNHLLILMGLNYVSGAVAGVIIGSAPVVTALLSAVLIQDVPLRLVLGGSLVSCMGVALVSVSGFRAAGERPLLGSVLVFLGVISWALYSIGSRAIMDRVSALTVNWTTLSVATALQIPLLWTDRKVTQAGWTSVGVHDWVALGYLIVFATAVAQQAWLYGVKGIGPSRASVLGNLTPVAAVALSALILGESVGMIEVVGITLILTGVWMVHRRMESHTVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5R1</accession>
    <name>A0A1W1I5R1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2158"/>
    <dbReference type="EnsemblBacteria" id="SLM48330">
        <property type="protein sequence ID" value="SLM48330"/>
        <property type="gene ID" value="NSJP_2158"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2158"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="59" mass="6849" checksum="1A2DDCAB50295100" modified="2017-06-07" version="1">MLRKTWSARPTLMRHYQPQRIIEIGSGFSSAVMLDTNEIWGGNRLALTLWILILNAFYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Z7</accession>
    <name>A0A1W1I5Z7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Quinolinate synthase</fullName>
            <ecNumber evidence="2 9">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">nadA</name>
        <name evidence="10" type="ORF">NSJP_2081</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the quinolinate synthase family. Type 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="2 9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2081"/>
    <dbReference type="EnsemblBacteria" id="SLM48253">
        <property type="protein sequence ID" value="SLM48253"/>
        <property type="gene ID" value="NSJP_2081"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2081"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00569">
        <property type="entry name" value="NadA_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023515">
        <property type="entry name" value="Quinolinate_synth_A_type3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="137"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="253"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM48253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="365" mass="41010" checksum="A73FC804AB85E0E5" modified="2017-06-07" version="1">MLATVPKPISDYQGLAGDELFRRTAQAKRVLGDRVMILGHNYQRDEVIEHADFRGDSLLLSKLAAERSERPYVVFCGVHFMAETADILSRSNQTVILPDMAAGCSMADMAAIEQVDQCWETLGRILPVEETVMPAVYVNSAAVLKAFCGEHGGITCTSSNARAVIEWCWARREKILFFPDEHLGRNTANKMGLPREQMIVWDPYQPNGGNSREAIKRAKLILWKGHCSVHQMFQPVHVDNFRKQYPDGKVIVHPECHEDVVNKADLSGSTEFIIKTVSAAPTGSIWAVGTELNLVNRLKRDMTDRKVFFLSSTVCQCATMFRIDGAHLCWAMENLADRHVVNHIVVPEDEKRWAKVALDRMMAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6E6</accession>
    <name>A0A1W1I6E6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Cytochrome b6-f complex iron-sulfur subunit</fullName>
            <ecNumber evidence="9">1.10.9.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_2410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.10.9.1" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2410"/>
    <dbReference type="EnsemblBacteria" id="SLM48582">
        <property type="protein sequence ID" value="SLM48582"/>
        <property type="gene ID" value="NSJP_2410"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2410"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="8">
        <location>
            <begin position="50"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="148" mass="16331" checksum="B632B0B8B0A543E4" modified="2017-06-07" version="1">MAIIHDDVGRRRFLSQAVMGFGMLFGMGTLGFRFVQFLLPNGAPRQPETVLIGSESRIPLGEAVPMDLGGQKILVLRTEGGVAAFSRRCTDLGCLVSWNREREQFICPCHQGTFDKTGLNISGPPPRPLDRLDVVKRGDQLYVNIQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6J7</accession>
    <name>A0A1W1I6J7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">nusG</name>
        <name evidence="9" type="ORF">NSJP_2327</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2327"/>
    <dbReference type="EnsemblBacteria" id="SLM48499">
        <property type="protein sequence ID" value="SLM48499"/>
        <property type="gene ID" value="NSJP_2327"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2327"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015869">
        <property type="entry name" value="Transcrpt_antiterm_NusG_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01014">
        <property type="entry name" value="NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="7">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="178" mass="19947" checksum="2C6BBF2C5D74BD12" modified="2017-06-07" version="1">MGKNWYVIHTYAGFEQRVKTSLLERANQMSLAEHLGQVLVPTEDVIEIKDGKRRTSRRKFFPGYVLVELETPLTDETLQMIKETPKVTGFVGGGAQPTPLTGEEVAELLKQVDAGNAGPREQVKFIKSDNVRIVDGPFMGFNGMVDEVDQDHNRLKVMVSIFGRSTPVELGFLQVERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6M1</accession>
    <name>A0A1W1I6M1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48678">
        <property type="protein sequence ID" value="SLM48678"/>
        <property type="gene ID" value="NSJP_2506"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2506"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012031789" evidence="1">
        <location>
            <begin position="21"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="125" mass="13838" checksum="9BAEA4B2BDB3E5C0" modified="2017-06-07" version="1">MKTAMVAALFGLLVVGSSCTVLVSKETRYLKAAKDHATQEQVHARLGEPKYTSVTTDGEPIWVYQVLFVDTGVNNQWGTPGAWCDEYVLTFDKQGILRDWTHKSEGHGGETMPTYCVRDGFKPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6P5</accession>
    <name>A0A1W1I6P5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="6">RNAP subunit beta</shortName>
            <ecNumber evidence="6 8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 15" type="primary">rpoB</name>
        <name evidence="15" type="ORF">NSJP_2331</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6 8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2331"/>
    <dbReference type="EnsemblBacteria" id="SLM48503">
        <property type="protein sequence ID" value="SLM48503"/>
        <property type="gene ID" value="NSJP_2331"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2331"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="12">
        <location>
            <begin position="27"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="11">
        <location>
            <begin position="176"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="11">
        <location>
            <begin position="351"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="13">
        <location>
            <begin position="520"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_45" evidence="14">
        <location>
            <begin position="598"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="9">
        <location>
            <begin position="725"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="10">
        <location>
            <begin position="1240"/>
            <end position="1314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SLM48503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1318" mass="147227" checksum="44F869690CBD0DBB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6U3</accession>
    <name>A0A1W1I6U3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="5">1.1.1.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_2569</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2569"/>
    <dbReference type="EnsemblBacteria" id="SLM48736">
        <property type="protein sequence ID" value="SLM48736"/>
        <property type="gene ID" value="NSJP_2569"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2569"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="4">
        <location>
            <begin position="184"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="338" mass="36771" checksum="CE1DE1B38A6F1690" modified="2017-06-07" version="1">MQLGMIGLGRMGANMVRRLLRGGHQCVVFDRSPKTVEELARDKAVGASSLADLVKKLHKPRAIWLMVPAAAVDQTIADLLPHLEAEDILIDGGNSYYIDDIRRAKELAPKRIAYVDVGTSGGVWGLERGYCMMIGGPKEVVQRLDPIFSALAPGAGEVPRTPGRETLGGTAEQGYLHCGPAGGGHFVKMVHNGIEYGLMAAYAEGMGILRNANIGKQQHHIDAETTPLRDPEHYQYDFNLTDIAEVWRRGSVIASWLLDLTAASLIKDQHLSQFSGRVSDSGEGRWTVKAAIDEAVPIPVLSAALYQRFSSRGEADYEDRLLSAMRFGFGGHVEVPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6V0</accession>
    <name>A0A1W1I6V0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytochrome_P460 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48742">
        <property type="protein sequence ID" value="SLM48742"/>
        <property type="gene ID" value="NSJP_2575"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2575"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032033">
        <property type="entry name" value="Cytochrome_P460"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038142">
        <property type="entry name" value="Cytochrome_P460_sp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16694">
        <property type="entry name" value="Cytochrome_P460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012415914" description="Cytochrome_P460 domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_P460" evidence="2">
        <location>
            <begin position="93"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="184" mass="20737" checksum="BD4A591F03A95DD3" modified="2017-06-07" version="1">MSKVINAWRRYRSSLVTGILLASAFAVAMPAGASAEDVAVSEETFGCILDWPKVRNTRFKHADPEKLKEAMRIFRDSVPDKDYPVGTILQLVPFEAMVKHSREKFPNTNGWEFFFLEVSKKGTTIKDRGDNVVNRSQGVTCLSCHQPAVKYDFVCEKGHGCAPIPFDDQKLAEIQRSDLRCTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6W7</accession>
    <name>A0A1W1I6W7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional deaminase-reductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2558"/>
    <dbReference type="EnsemblBacteria" id="SLM48725">
        <property type="protein sequence ID" value="SLM48725"/>
        <property type="gene ID" value="NSJP_2558"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2558"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="8"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="214" mass="23036" checksum="3C9405268E02EAE1" modified="2017-06-07" version="1">MGKVKVAAFSVSLDGFGAGPGQALKNPLGVRGLELHSWILDTDVFKKMQGEGEGTHGIDNDFAAQSMDNIGAWILGRNMFGPVRGPWKDESWKGWWGDNPPYHTPVFVLTHHARAPLRTEGGTTFYFVTDGIESALQKAKDVAKGQDVRIGGGAATIRQYLTAGLIDQIHLALSPTFLGEGEHLFAGLNLHALGFTSIKTAAGEKATHVVMEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6W8</accession>
    <name>A0A1W1I6W8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2611"/>
    <dbReference type="EnsemblBacteria" id="SLM48778">
        <property type="protein sequence ID" value="SLM48778"/>
        <property type="gene ID" value="NSJP_2611"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2611"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002860">
        <property type="entry name" value="BNR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02012">
        <property type="entry name" value="BNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="395" mass="43777" checksum="51E1E5414CCBE1D4" modified="2017-06-07" version="1">MSKVRLLVGTRKGAFILTSDGARKHWEVDGPLFGGWEMYHLKGSSADPMRLYASQTSSWFGQIIQRSDDGGKTWHQPGTPPGEPTTTPDGMPKGESNKFVYDTSEATGRPLTTHQWYDGSQRPWEFKRVWHLEPSLTDPDTVYAGVEDAALFRSTDGGASWTELASLREVKGPLWQPGAGGMCLHTILLDPNDAARMFIAISAAGAFRTEDGGKTWRAVNRGLKSQYELPDPDSDVGHCVHRIAMHRSRPNVLYMQKHWDVMRSDDGGDSWHEVSGNLPTDFGFPIDVHAHEPETIYVVPIKSDSEHFPPDGKLRVYRSRTGGNEWEALTNGLPQRDCYVNVLRDSMTVDSLEPCGIYFGTSGGQVYGSADGGDRWTAIVRDLPPVMSVEVQTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I756</accession>
    <name>A0A1W1I756_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolyphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gppA</name>
        <name evidence="2" type="ORF">NSJP_2471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2471"/>
    <dbReference type="EnsemblBacteria" id="SLM48643">
        <property type="protein sequence ID" value="SLM48643"/>
        <property type="gene ID" value="NSJP_2471"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2471"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="24"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="318" mass="34549" checksum="6A9A7DDE8EFD8EE4" modified="2017-06-07" version="1">MRLAGIDIGTLTCRLLIADLLPDGRLKAVHAERRILRLGEDVDRSKRLSVAAMERVVHCLKGWHEAVGEHRIDGCAVVATSAVRDAANRSEFLALVTRETGLTVDVISGDEEARRTMRGIRSGLPAGVTGVLGLDIGGGSTEFILDRPGRQPVVKSIDIGVVRLSERILHHDPPTAEEIQRAREWVRQETERAMADMPSRAGLTFVGTAGTITALAAMAQRLSSYEPARIHNYRLTLEIIVDLERQLLGRTKAARVGLPGLEKNREDVIAAGAVIIRTVMDALGEKECLVSDLGLREGVLLTLADRLAAGRTPFTTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I791</accession>
    <name>A0A1W1I791_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Sulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48877">
        <property type="protein sequence ID" value="SLM48877"/>
        <property type="gene ID" value="NSJP_2710"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2710"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008476">
        <property type="term" value="F:protein-tyrosine sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006478">
        <property type="term" value="P:peptidyl-tyrosine sulfation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026634">
        <property type="entry name" value="TPST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788">
        <property type="entry name" value="PTHR12788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="603" mass="67186" checksum="2CCF33D5222C8F11" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7G8</accession>
    <name>A0A1W1I7G8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48753">
        <property type="protein sequence ID" value="SLM48753"/>
        <property type="gene ID" value="NSJP_2586"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2586"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001826">
        <property type="entry name" value="RHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00394">
        <property type="entry name" value="RHSPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="455" mass="50849" checksum="78851778B93D7273" modified="2017-06-07" version="1">MDLGGFERYRRYAGGHVVEEIETHHVTGDSRRFLLVDDVLRTDHPRLSTGAHYRYQLGNHLGSACLELNDDAEVISYEEYHPYGTSAYRATNNAVEAPMKRYRYTGMERDEESGLNYHSARYYAPWLGRWVSADPFSLIDGGNLIGYALDNPIGRTDTSGLASTGEVTEFDSDKLIKEFDALPNVSGDWIEAHKKFNETVQANLLEEPTPTTAREKSVDADIETEAHDRAVVNIVNAAIDTASALVRSKGIEVSEHDLLKIALQMVVYPYRTGHGLTENLILRDVDHFLTGRIQAWRDYVPRIPLVDIAPLGKGATNDPGIILLGNYAAMVYDDIKRVSFRTHPKPDEKHAKSSMDQDSKPASAPGGRFWAYFGGDLLTTRDHPSESAAPWKLKISYDDVKAARSTWSVMKTALEISYEVAKQKAAQTLQELIDAIENMGDPTGTLRFIGERMHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7H0</accession>
    <name>A0A1W1I7H0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48957">
        <property type="protein sequence ID" value="SLM48957"/>
        <property type="gene ID" value="NSJP_2790"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2790"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="90" mass="9254" checksum="F331E508345345F6" modified="2017-06-07" version="1">MREMMRCGGIVGIHTPVILSILLSGCGLMMIGPPAEKIDVDSGSNEQKNLEAVRAMQADQAGHAASGASTGQESSPCAPDGVGKNRCADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7R3</accession>
    <name>A0A1W1I7R3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2732"/>
    <dbReference type="EnsemblBacteria" id="SLM48899">
        <property type="protein sequence ID" value="SLM48899"/>
        <property type="gene ID" value="NSJP_2732"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2732"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="220" mass="24600" checksum="BB05F0C25608DFED" modified="2017-06-07" version="1">MTAFFSLPADRNLSDRPLERLLGKDGFTILEIIIVLFLLTGLLTILIPRIGIGETLASNGRKWVSTFRTFQEMAVAGQKPVRLHIDLERGQYWPMILQDGEERLPFNEAWQVPINLPESIHITDIQIGQKKSTAGRIAVLFYPNGKIDPVVMHLIDDSNNLLGIQVEPVTATIRVSDQRIEPPRPWILPERIRQLLQIQQSLPGLKPVAPVAPVAPAGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7T0</accession>
    <name>A0A1W1I7T0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49082">
        <property type="protein sequence ID" value="SLM49082"/>
        <property type="gene ID" value="NSJP_2915"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2915"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="261" mass="28906" checksum="ED3E9450D17E2407" modified="2017-06-07" version="1">MRRIGPSPWRSLLCLCLAVAAGGWTGCSSSVLGWHVRTNSTPHLPSFDYRALEREPVALFGALGLIPIQGNEVGVESFLETILNRVAPGIKVVGPRETVTRINQAGLAEDYARMRDAALQSNILAREPLRALGKAAGARYVFQPRLMLFTQVLTDRWVFPVFGVRVSQTRATTVRLALQLWDTDTGALLWNSVAEGTMQSEAMTQDPVYFKDIARVTLGSMVEDFVRDRTDSMYTPVDTLLNSLVERPVPVTDDTPLEKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7U8</accession>
    <name>A0A1W1I7U8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2919"/>
    <dbReference type="EnsemblBacteria" id="SLM49086">
        <property type="protein sequence ID" value="SLM49086"/>
        <property type="gene ID" value="NSJP_2919"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2919"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06325">
        <property type="entry name" value="PBP1_ABC_unchar_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007487">
        <property type="entry name" value="ABC_transpt-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35271">
        <property type="entry name" value="PTHR35271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04392">
        <property type="entry name" value="ABC_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="331" mass="36584" checksum="B69BB2A219A9D7E2" modified="2017-06-07" version="1">MKSQDAYIERFVSSPVYFAAWTLATICTLPMVLLGLLGFIEWIGTADAQAADIAILKSSSIAAYDQAIDGFKATAPSDAVYMEFDLQGDLEMGRKLARKIRASDPALVVAVGLKAAQAAKMEILDTPIVYMMVLDPQRHNLASPNLTGTLLEIPVERQLKLIRTFLPGKRRFGTLYDPRKSTTKVREAEQQAAALSFELKSLPVESEKDVPQQLRTLLTFNETLWLMPDSTVLTNESIGFILESAQARGIPVVGFSPELTRLGALLSFSVTYGEVGRETGLLAKRILDGDKRLPLKPVPIERLKITVNMKIARFLGIEFPRDVSHLIDEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7W8</accession>
    <name>A0A1W1I7W8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49122">
        <property type="protein sequence ID" value="SLM49122"/>
        <property type="gene ID" value="NSJP_2955"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2955"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013207075" evidence="2">
        <location>
            <begin position="25"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="138" mass="15097" checksum="F3C3765008AB5238" modified="2017-06-07" version="1">MNCVMRMWMPLSLAGVLLAAPVWAGESETFDPDQPFNELHGKLFLESLAAQALDLLKDHLDISADSRSGENGTSGRQSLRFKFYPDGRSKSDQYFAAEGWLGPSSDAQRQELHFRFSLPGASSGPADTPGQPQPDNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Z4</accession>
    <name>A0A1W1I7Z4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yqgF</name>
        <name evidence="5" type="ORF">NSJP_2959</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2959"/>
    <dbReference type="EnsemblBacteria" id="SLM49126">
        <property type="protein sequence ID" value="SLM49126"/>
        <property type="gene ID" value="NSJP_2959"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2959"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="4">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="187" mass="20671" checksum="001E468F95BF0274" modified="2017-06-07" version="1">MEGRRILALDYGTKRIGVALSDELGWTAQPLETFERRTLDRDIEHIASLVGSHEVGRVVLGFPLQLDGREGPAIQAMREFSDRLERRLPVPLVLWDERMTTKAAEDLLIAADVSRKKRKGAVDRVAAAILLQSYLASLAPPPSGPDDESDFEGESLAHAHDIPDHPHTAPVRGRRAGRGRLSRDEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I894</accession>
    <name>A0A1W1I894_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49220">
        <property type="protein sequence ID" value="SLM49220"/>
        <property type="gene ID" value="NSJP_3053"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3053"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="65"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="283" mass="31601" checksum="31BB86DBAF74A2DD" modified="2017-06-07" version="1">MAKTGPSDPSRDQTRINVKAFEQIDEAANVQDYIRILDVFDSLDGIQRLKKAAIDRCRIRPGLSVLDNGCGIGLETIRLARLVAPSGKVTGLDYSLKFLDEARRRASRLELPATYQQGDAQQLPFSSRTFDVSRSERLFPYLIDPKQALTELIRVTKPGGFVSLIEPDFETVTINLSDRGLVRKVLHFDCDHHTKNGWIGRELPRLFKSCGLIDVAVEADVVVFEPAGFSPYFVEIGRAAAQNQVITAQELTGWEEEIRQLLAANELFATISYFMVAGKVREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8A8</accession>
    <name>A0A1W1I8A8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sigma70_r4_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49236">
        <property type="protein sequence ID" value="SLM49236"/>
        <property type="gene ID" value="NSJP_3069"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3069"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="2">
        <location>
            <begin position="246"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="336" mass="38451" checksum="AB04F13ABB9BE68E" modified="2017-06-07" version="1">MAIRGRAASEELKQERCNRWRLLIRNDAFRTDLIRIIRRYAKWVTGPALAVVLYLDGECINALLERKDAFLRTYRILDHGDKFLLDWAKFTSEHNVAFPEQIIEDIRLGQFPPLEPVPAPEWDALGQDDSLLPPAWKLLSTGLHDIPSDWYGVLLNRSYPKSLVMEALRAYLPMQTKRSRRDKAEVRLRLHDTAVKNRRAVGRCSTTRSRLKAATVAIGNTLPCSSQDTDSEEEPKVPEAPRDEQQDIADALSRLSAEQRRAFEAVYRDGLTEQAYARQVGRTVEYVKLLVQSARAQLRVFLETQGYEAPQDEVEVSPLLAPGCRRKSYRRSFDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8F1</accession>
    <name>A0A1W1I8F1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49302">
        <property type="protein sequence ID" value="SLM49302"/>
        <property type="gene ID" value="NSJP_3135"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3135"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="61" mass="7176" checksum="DC97D29CE6EC9C55" modified="2017-06-07" version="1">MTVFSLADILHFIALENRRWYRQVTRIPTAPVNLERIGLHAQKVRVDEENGNHQKLDRVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8R6</accession>
    <name>A0A1W1I8R6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">def</name>
        <name evidence="3" type="ORF">NSJP_3092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3092"/>
    <dbReference type="EnsemblBacteria" id="SLM49259">
        <property type="protein sequence ID" value="SLM49259"/>
        <property type="gene ID" value="NSJP_3092"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3092"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="176" mass="19594" checksum="2BB2A7900875A417" modified="2017-06-07" version="1">MAVLPIAKLGNPILRKIAAPVDVREIRTKEFQQLIDEMFETMLDEPGIGLAAPQVSRSIQLVVMGCEGEGGFPTTTLINPKIVYYGPQQAENWEGCLSVDGLRGKVTRPSVIRVQALDRDGKPVDIEADGLYAVCVQHETDHLLGKLFVDRMTDLSTLTQLTEFDKYWRKEPTPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I984</accession>
    <name>A0A1W1I984_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">gmk</name>
        <name evidence="11" type="ORF">NSJP_3420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3420"/>
    <dbReference type="EnsemblBacteria" id="SLM49587">
        <property type="protein sequence ID" value="SLM49587"/>
        <property type="gene ID" value="NSJP_3420"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3420"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="24"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM49587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="235" mass="26917" checksum="795344ABC4918D27" modified="2017-06-07" version="1">MSVTTKNPARSPAGPMGASLHRHGVLFIISAPSGTGKTTLCKQLVASIPGLWHSISCTTRKPRAGEEHGREYFFIEEATFQEMIDRHEFVEWARVYGHLYGTPRKSLTDKLDQGIDVLLEIDVQGALQVKKKFDDSVSIFILPPSMAALRTRLQTRASDAPEEIQRRLQKVKEEVWNYRQYTYVVRNDELGRSLRELETIFLAERSKTARMDTAWIERDFLLADESQSENRTDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I998</accession>
    <name>A0A1W1I998_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetoacetate metabolism regulatory protein AtoC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atoC</name>
        <name evidence="9" type="ORF">NSJP_3398</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3398"/>
    <dbReference type="EnsemblBacteria" id="SLM49565">
        <property type="protein sequence ID" value="SLM49565"/>
        <property type="gene ID" value="NSJP_3398"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3398"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="145"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="452" mass="51011" checksum="8ADF194DD0A48166" modified="2017-06-07" version="1">MTDRAGIIVVDDEINIRNALVTVLSKQGYDVRGVGSGEEALEELTRCGAELVITDLKMPGVGGIEFIRRLKAAWPETEVVVMTAYGSIDTAVEAMRSGAYDYLTKPIDRERFPLVVTKALERRALANENKQLRDRLETRVRYDQMVGESEPMQRVYSLVEMVADSGVTVLLTGESGTGKELVARAIHHKSARADGPFVTLNCGALPENLFESELFGYEKGAFTGATTTKVGRFELADNGTLLLDEIGELSLKSQVDFLRVLETKEFRRLGGTKVIKVDARIVAATNRNLEEAVKQGDFREDLYYRLNVVPIRLPPLRERGEDIPLLAERFLREFSAQHHRDLKEISRDVMRLMRLYAWPGNIRQLRNLMERLVITVKEPAIQPEHLPEEIQASQEHARTMVVTLGTSLNDIEREAIRRTLAEVVNHREKAAKLLGISLRALQYKIKEYGIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9B8</accession>
    <name>A0A1W1I9B8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49596">
        <property type="protein sequence ID" value="SLM49596"/>
        <property type="gene ID" value="NSJP_3429"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3429"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="76" mass="9137" checksum="F8FEFB59EE80963B" modified="2017-06-07" version="1">MDSAYVIVETYAGNKGERTPRSFTHGKMHRIVTDILDRWYTESHCYFRVRADDSLRYVLRHQLDEESWELVMRELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9C6</accession>
    <name>A0A1W1I9C6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49637">
        <property type="protein sequence ID" value="SLM49637"/>
        <property type="gene ID" value="NSJP_3470"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3470"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="63" mass="7166" checksum="4E6501D34D44BDC5" modified="2017-06-07" version="1">MMIVLPCPLHETGQYHTMRGQVSLRIGFEAGKDRRKPKGMGVARSGRLRYGTDPLRLTSRLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9D5</accession>
    <name>A0A1W1I9D5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha</fullName>
            <shortName evidence="10">ACCase subunit alpha</shortName>
            <shortName evidence="10">Acetyl-CoA carboxylase carboxyltransferase subunit alpha</shortName>
            <ecNumber evidence="10">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">accA</name>
        <name evidence="12" type="ORF">NSJP_3480</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the AccA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3480"/>
    <dbReference type="EnsemblBacteria" id="SLM49647">
        <property type="protein sequence ID" value="SLM49647"/>
        <property type="gene ID" value="NSJP_3480"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3480"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00823">
        <property type="entry name" value="AcetylCoA_CT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03255">
        <property type="entry name" value="ACCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01069">
        <property type="entry name" value="ACCCTRFRASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00513">
        <property type="entry name" value="accA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="11">
        <location>
            <begin position="37"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM49647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="322" mass="35938" checksum="F53F91FB8A159D9F" modified="2017-06-07" version="1">MRDYLEFEKPLREIEEKIEKLVTSGSTKASHQEEIRKLRMKLAQVEHDLYNGLTPWQRTQLARHPQRPSTLDYINEIFRDFLEFHGDRSFGDDRAIVGGFARFNDRSVMVIGHQKGKTLKERMQRNFGMPNPEGYRKALRLMKMAEKFNRPIVTFIDTPGAYPGIGAEERGQAEAIARNLLVMSRLSVPIVSIVIGEGGSGGALALGVSDRVLMLEHGVYSVISPEGCAAILWDDPAKVPDAAFALKMTAQDLQGLGIVDDIIPEPIGGAHREPRAVTDRVAKTLTNYLFPLTECSIAQLLAEREQKYRRIGAVNGLEAKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9E1</accession>
    <name>A0A1W1I9E1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="8 10">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">hisA</name>
        <name evidence="11" type="ORF">NSJP_3467</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8 9">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="8 10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3467"/>
    <dbReference type="EnsemblBacteria" id="SLM49634">
        <property type="protein sequence ID" value="SLM49634"/>
        <property type="gene ID" value="NSJP_3467"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3467"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006063">
        <property type="entry name" value="HisA_bact_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00007">
        <property type="entry name" value="TIGR00007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM49634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="246" mass="26643" checksum="D4B50FDE2B787D94" modified="2017-06-07" version="1">MIVIPAIDLKDGRCVRLRQGDMAAETVYSEDIPTVARRWQEQGAEVIHVVDLNGAVDGEPRNLPQIEQVMRHVDVRVQVGGGIRNIQTVRRYLKAGVSRVVLGTAALTDRAFLEQACKEFPRRILLGLDARDGKVAIKGWTAVSDRLAVDVLKEVSGCEIGAVIYTDIARDGMLAGPNIRALQEVVDRSSFPVIASGGISKLEDLRAVQTLGPRIEGAIVGKALYDGKLDLRAAIAATATNGQDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9J9</accession>
    <name>A0A1W1I9J9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Outer membrane channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49670">
        <property type="protein sequence ID" value="SLM49670"/>
        <property type="gene ID" value="NSJP_3503"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3503"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012438737" evidence="1">
        <location>
            <begin position="37"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="441" mass="49292" checksum="B1A80DC426A1CCC5" modified="2017-06-07" version="1">MSGTGRAPNYHVPQFMTLAVALLLLLSDATISGVMAADEEPTPLAGEPFHTEVLGEPVKVPPRDRKKVTAASFGISVLPEGPKFYQVLPFGAMYLWRNSDDMKQRFRATLSGPVNDMTMNVGSHSSSGWELRLTFQNMIIPVGRSEYVEAQIIRDVEVEWNYVFGGIGLAYRKLLDPGHQDNAFEVSLTYEPGYRWFKGTSKTSSNFIVPTDTYEGRVHARLRNDALERNLMELPHRGYSFGGDFYYGNRAHWNDWGGGLFGVSSGQQGKQYLMGSVFAVSATPVPFIDSEKHRLIGSVYGGIGQHLDRFSTFRLPGRPTGYEWEAIALPMLPSVAFNELFPTRYGIAHLEYRYEPIFFIYPYVRGSWGIVEQPRFNPDGTVRNIMGSMPAVGGGVVSGAPWSSQIEINYSYNFGIFRDQGNGQSAQGRNGFFIFWSKELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Q2</accession>
    <name>A0A1W1I9Q2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49726">
        <property type="protein sequence ID" value="SLM49726"/>
        <property type="gene ID" value="NSJP_3559"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3559"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="123" mass="12782" checksum="7AA2176C6B31EC2E" modified="2017-06-07" version="1">MANQLPVSADMSLSQKGFAVTRGQYFLLLAVVFLGNVVGSALTGIIFDSSSAGAEKAKGINAEEFLLLDSSGKARAGLGLDPQGEVGFILTSRDGSKKLALSPDEPLAIKLSDRSGRVLWSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9X7</accession>
    <name>A0A1W1I9X7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Ion transport 2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49857">
        <property type="protein sequence ID" value="SLM49857"/>
        <property type="gene ID" value="NSJP_3690"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3690"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="231" mass="25039" checksum="A3D0F8AF8479E7C5" modified="2017-06-07" version="1">MKAFFNRLSDLMPADASLTVLLGFLIADLFVLQPIEALSGWAKLLIDIVTVTGIVLSILAVLGLQRATGIFVVLAGAALLLRGLRLVVPGDGIGYVQSVLSLVAIAILAWLVLKLVLRSGRVTIRRIQGAVVVYLLLGMMWTQAYRMIALYDPSAFVLTDEVSHIDPEINSKLGMFSFSVLTASSFIDMTPVNPVARSLAMLEALIGQLYLVILIARLVSLEVESNRMGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA20</accession>
    <name>A0A1W1IA20_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lpd</name>
        <name evidence="16" type="ORF">NSJP_3562</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3562"/>
    <dbReference type="EnsemblBacteria" id="SLM49729">
        <property type="protein sequence ID" value="SLM49729"/>
        <property type="gene ID" value="NSJP_3562"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3562"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="4"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="341"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="179"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="313"/>
            <end position="316"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="40"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SLM49729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="475" mass="50372" checksum="08DD0B33057E3E3F" modified="2017-06-07" version="1">MPKHIVILGAGPGGYVAAIRAAQLGARVSVVEAQALGGVCLNWGCIPSKALLAVVELGDKLKHAESMGLVLEGNVAYDLARMVSRKNKVVETLVKGIATLFKSWDIRHLEGVGTIRGKGMVHVALNDGTEQTLEADAVVIATGSSWPNPSQFPIDGRVIVTSRQLLDLSTIPRRLLILGGGVEGCEFATLYSGLGTEVTVVELVDRILPLEDEEVSATMARELKKRGVTVMTGTTVDSVERGESAITVHCKNGEKIVADMFLVSVGRGFNSRGLGLEEAGVELGRRGEILVNERMETTVSDIYAIGDVVGKAMLAHVASAQGKVAVENIMGHRSTIRYEVIPAGIFTLPEIGRVGLTEAQARERMRANGLDADAAVKVGRFRFVATGKAQATGETTGFCKIISESESGRILGAHIIGSHAADLIHEAALAMEIGANVNQIADMIHAHPTMAEGMMEAAEDSGRGAIHQVRKRANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA24</accession>
    <name>A0A1W1IA24_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc-type alcohol dehydrogenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3689"/>
    <dbReference type="EnsemblBacteria" id="SLM49856">
        <property type="protein sequence ID" value="SLM49856"/>
        <property type="gene ID" value="NSJP_3689"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3689"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08252">
        <property type="entry name" value="AL_MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014182">
        <property type="entry name" value="ADH_Zn_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02817">
        <property type="entry name" value="adh_fam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="13"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="337" mass="36469" checksum="1F3D0142E572E129" modified="2017-06-07" version="1">MKAVGYRQSLPISDPSSLLDVELPDPRPEGRDLLVSVKAVSVNPVDTKVRMRYKPASGETKVLGWDASGVVLEAGPHATLFKAGDEIWYAGSIARPGTNSALHLVDERIVGRKPVSLDHARAAAMPLTAITAWELLFERFNIQPGKHHTGDSLLVVGAAGGVGSILVQLARHLTGLTIIGTASRDETAQWVRQLGAHHVIDHSKPLSAELRRAGLAPPTHVAGLTHTGEHYPEIVEALAPQGHLALIDDPDSINIDLMKRKSLSLHWEFMFTRSFFGTHDMIAQHRLLCEIADLVDGGAVRTTFGQHFGTINADNLKRAHTLIESGKAKGKIVLEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA35</accession>
    <name>A0A1W1IA35_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA repair protein RadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3751</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49918">
        <property type="protein sequence ID" value="SLM49918"/>
        <property type="gene ID" value="NSJP_3751"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3751"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="46"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="170" mass="18674" checksum="E13A102C5866DBE4" modified="2017-06-07" version="1">MDPAQPQQPLSRTRLLNRTGTFAPYRVPKYRITLVCEEAGPESSGPIQTSSGAALLLRSCFHGLDREQFLVCGLDAKHHVIGINIVSIGSLTLSIVHPREVFKPLILMNAAAFVCAHNHPSGDSTPSEEDRLLTRRLRQGADLLGITLLDHLVLGENRHYSFTDQGWPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA40</accession>
    <name>A0A1W1IA40_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3614</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3614"/>
    <dbReference type="EnsemblBacteria" id="SLM49781">
        <property type="protein sequence ID" value="SLM49781"/>
        <property type="gene ID" value="NSJP_3614"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3614"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="164"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="343"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="633" mass="73406" checksum="DBF5D3CF0D7FA73C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAQ9</accession>
    <name>A0A1W1IAQ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anti-FecI sigma factor, FecR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3927"/>
    <dbReference type="EnsemblBacteria" id="SLM50094">
        <property type="protein sequence ID" value="SLM50094"/>
        <property type="gene ID" value="NSJP_3927"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3927"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032623">
        <property type="entry name" value="FecR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16220">
        <property type="entry name" value="DUF4880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4880" evidence="2">
        <location>
            <begin position="18"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="1">
        <location>
            <begin position="119"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="330" mass="36261" checksum="828ABB3E98E0AB4E" modified="2017-06-07" version="1">MTATTMSSDLRHQEIFAEAAQWVVRLGAESVTEAERAACRRWKAQSPVHEAAFDHAEGMWRHVAQVGQMSHESGISAKAAPSLASVNRSRWLPIAACCAGLALASIFLFEEVRVLMTADYRTVAGERREVALPDNSRVTLNTGSAIALHFDDHERRVELLNGEALFVAAPMQGAETRPFVVSAGSSRARAMGTQFLVRRTGRTEEVTVIEHRVAVSLQRESAFMPVVVDAGHRVRYDSVSGLGAVADANIDQATSWQRGRLMFDRMPLDEVIAEINRYRRGRIVVLNKELAGRRVSGVVMIDKIDDSLSLITSELGATTTSLSPLLTFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAR9</accession>
    <name>A0A1W1IAR9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-deoxy-manno-octulosonate cytidylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">CMP-2-keto-3-deoxyoctulosonic acid synthase</fullName>
            <shortName evidence="2">CKS</shortName>
            <shortName evidence="2">CMP-KDO synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">kdsB</name>
        <name evidence="4" type="ORF">NSJP_3980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23448"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:85986"/>
            <dbReference type="ChEBI" id="CHEBI:85987"/>
            <dbReference type="EC" id="2.7.7.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KdsB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.38" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3980"/>
    <dbReference type="EnsemblBacteria" id="SLM50147">
        <property type="protein sequence ID" value="SLM50147"/>
        <property type="gene ID" value="NSJP_3980"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3980"/>
    <dbReference type="UniPathway" id="UPA00358">
        <property type="reaction ID" value="UER00476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008690">
        <property type="term" value="F:3-deoxy-manno-octulosonate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033468">
        <property type="term" value="P:CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02517">
        <property type="entry name" value="CMP-KDO-Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00057">
        <property type="entry name" value="KdsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004528">
        <property type="entry name" value="KdsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00466">
        <property type="entry name" value="kdsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="236"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="266" mass="29459" checksum="1464220FC1E5346F" modified="2017-06-07" version="1">MTGMKPQVMVVIPARYGSSRFPGKPLVKLGQKPLIQHVYEQAASCRSVTEVLVATDDERIRETVERFGGRVAMVTGDYRTGTDRVAAVARTVSGEYFLNLQGDEIPETPALLKDLIDSFLGCDAEMGTLKRAMGTDEALDNPAAVKVVTDSDGHALYFSRAPIPLVRDGIRGQVVGGLHYLHLGLYIYRREALLRFASWPTGQLEDAEKLEQLRALQQGMRIRVWDTSHRSLRVDTPEDAAEVADKLRRHESRKQDSPIGGTVSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAT7</accession>
    <name>A0A1W1IAT7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50095">
        <property type="protein sequence ID" value="SLM50095"/>
        <property type="gene ID" value="NSJP_3928"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3928"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="10"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="109"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="172" mass="19668" checksum="D6B52B9BD6317557" modified="2017-06-07" version="1">MSTEKDLGSLFLAHRPELQAWLTRKLRCPHMAADFTQDIFLRLAELPASKVIGNVRSYLYRSAHNLVIDHFRKAERQQTFPTAHEQLLDIPEERAPADVALSAHQEWVRLQAVLGNLPERTQHIFMLNRVDGLTYTQVASRLGISESSVQKHLSKALLEVMTHCHSREHGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAU1</accession>
    <name>A0A1W1IAU1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Nucleotidyl transferase, Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.-" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3726"/>
    <dbReference type="EnsemblBacteria" id="SLM49893">
        <property type="protein sequence ID" value="SLM49893"/>
        <property type="gene ID" value="NSJP_3726"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3726"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="276" mass="30123" checksum="6734ADFAECFFB831" modified="2017-06-07" version="1">MSETTSCDDAGEVVGLIPAAGLATRLQPLPCSKELLPIECVRDERSGLARPKVASEYLLDKFRAAGIAKAFWVIRSGKWDIPNYFRDGASMGMSMAYVVISDSLGPPDTIDRAYPLVSRYRIAFGFPDILFGPSDVYARLIQRQERTGAAVVLGLHRIAEVRTWDMVETDEDGLVRRIEMKPASTMLSYGWGCAVWTGVFTEFLHRFLRSPETTRDFSRLTSKANDPGGDVAMGVVLQAALTAGIPVQSVHLPGESPLDIGTPENLAKAMREGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB74</accession>
    <name>A0A1W1IB74_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4085"/>
    <dbReference type="EnsemblBacteria" id="SLM50252">
        <property type="protein sequence ID" value="SLM50252"/>
        <property type="gene ID" value="NSJP_4085"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4085"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024623">
        <property type="entry name" value="YtxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12732">
        <property type="entry name" value="YtxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="103" mass="10867" checksum="0958A0A203BF0DB6" modified="2017-06-07" version="1">MADNHGSAAGVVLAFLSGAALGAVAGLLLAPRSGRDSRELLRGYARQAEDSLRDLAGQAGETLEGAIDQGKEFVESKKSVLREAFEAGREAVKRERDRVRGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBB8</accession>
    <name>A0A1W1IBB8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Multidrug efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3896"/>
    <dbReference type="EnsemblBacteria" id="SLM50063">
        <property type="protein sequence ID" value="SLM50063"/>
        <property type="gene ID" value="NSJP_3896"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3896"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="876"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="902"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="951"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="979"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1033" mass="111499" checksum="B75CF6F5463FE7F7" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZM0</accession>
    <name>A0A1W1HZM0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 4">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">galU</name>
        <name evidence="6" type="ORF">NSJP_0023</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0023"/>
    <dbReference type="EnsemblBacteria" id="SLM46195">
        <property type="protein sequence ID" value="SLM46195"/>
        <property type="gene ID" value="NSJP_0023"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0023"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="65"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="360" mass="39902" checksum="A949D9BB3BDD0357" modified="2017-06-07" version="1">MHSTQTHPHERSAQNCWIIGSKYFNVKRFWAVGSSRRSVRAGHAFLDFTYPITYYQRMSRSNVRKAIIPAAGMGTRFLPATKASPKEMLPLVDKPLIQYAVEEAVASGIEDIIVVTGRGKRAIEDHFDRSVELEENLKGNGKAQLLSQMRHISNLANFCYVRQPEALGLGHAVLCAQRLIGDEPFAVILGDEIIDAQVPGLAQLIHTYKRRNGAVLGVQEVPHQEVNRYGIVSPGKLATGLHRVLDVVEKPSPSDAPSNLAVIGRYVLPPEVFPILRKTRPGKNGEIQLTDALKELARAAPMYALEIQGQRYDAGDKLGFLIATVEFALKNPALGSEFTDYLHARMTPQKGQRRSRAHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZQ1</accession>
    <name>A0A1W1HZQ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Murein hydrolase EnvC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0053"/>
    <dbReference type="EnsemblBacteria" id="SLM46225">
        <property type="protein sequence ID" value="SLM46225"/>
        <property type="gene ID" value="NSJP_0053"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0053"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012664274" evidence="2">
        <location>
            <begin position="27"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="294"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="173"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="394" mass="44938" checksum="10091868C83A6533" modified="2017-06-07" version="1">MRHWTAGFLLAACLVSSLGAASQVSADAISDKIEKERKMLERLKDQIEEKRKQADEAGKKRDSLLQGLQTLDERLVQVRHANQDVSRKIRKKDQEIETINQQITKLQGSIRQRRDAILARLRVQYMEGRSGYWKTLLASDSYGDFQRRLQYLSAVSERDYALLETFKSDVNDMEEAERQRESARAGMRVYKQSTEKQLHEMSSVKKEKKVYLTKITQEKESSERALQELEKSAVRIDSLLRELEQRRRAALARPPVAGTQHRGVKGMLPWPVDGSVISYFGRQKHPTFNTYVQRKGIEIRASEGSLIHAVMQGTVVYADWLKGYGLVIILDHANGFFSLYAHASKILTTVGAQVTANQAIGETGDTGMTKENTLYFELREGTEAVDPMQWLTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZU5</accession>
    <name>A0A1W1HZU5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytochrome_C554 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0104"/>
    <dbReference type="EnsemblBacteria" id="SLM46276">
        <property type="protein sequence ID" value="SLM46276"/>
        <property type="gene ID" value="NSJP_0104"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0104"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023155">
        <property type="entry name" value="Cyt_c-552/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13435">
        <property type="entry name" value="Cytochrome_C554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome_C554" evidence="1">
        <location>
            <begin position="54"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="431" mass="47635" checksum="13D8188F7EE87A3C" modified="2017-06-07" version="1">MQGRRRIITAAFLFLAIGVIGLFHDRAIAEKADGQASGDWISEIEKIFIRSEDCKQCHDRHYEEWKGAREQTPDLKTFGRVDAALLHGTSLESPVFRTVLGLWIQTNPTAEERTRCLSCHVPSTTVFPQHAEKMVTQVLAGKPKIEGIGCASCHLIKSVQTTAAPPPTFVIEPDKTMYGPYADPEENLVHPAMQSDLYRGANFCASCHFDKVKDVTQKNLPGEILQGTICQDCHMEPSTGSSTSKRGAMTRSIGRHWFRGVVIPGTLLKNRNLQAEWMPRIDIETAKSSANVEGTVLVKVGSLPHSFPDGDPILKQFFLEITVKDIRGAVLASETKRFGLGYDKILRGPIPDPFIKGGNTRKVPFSLAVPAGGSPTLIEAVLSYGLIPDPAPELKKQYLATLPDDKDREAAMKVIEEYTQPRMLTYRAKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZZ9</accession>
    <name>A0A1W1HZZ9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NFACT-R_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0155"/>
    <dbReference type="EnsemblBacteria" id="SLM46326">
        <property type="protein sequence ID" value="SLM46326"/>
        <property type="gene ID" value="NSJP_0155"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0155"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="2">
        <location>
            <begin position="352"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="480" mass="54232" checksum="6582A02F27821B05" modified="2017-06-07" version="1">MSLTDLEITHVLAEIQATVGTGWLQRIFQPDIHVLVFEIRIPGRTHRLLVSCQPDCARLHLLTGQVRNPPRPPAFCQYLRAHIQGARIDGFCQIPGDRIVEWRLTTKEGSRTLLCQLTGRQANVYVLDPTGVILKDLFGDRTLVGTHYRPPGRPDHTGRNRTSRFPASNDSGDCPISAAIEHHYQDREASATLDQIKDIRRRALKKTTQKAQRRIEAWRQDLAKATRFQEYARYGELLKANLGMIRKGMDQVLLTDYFDPEMPEISLPLDGTKSAQGNMEEYFRKYRKYSAAQQELQPRIAQAEQDLAELRQELADMEQGTWSPPVSEPASGTLRPSRRAKAGQANQRRAPFRRFVSTDGLAILVGRNARENDELTFGLANSDDLWLHARGIPGSHVVVRMEKGTDVPPATLLDAATLALLYSDLRKSGKGEIIYTRRKWVRKAKNQAPGAVLVAREQSLTVRLDQVRLANLKERAKENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I069</accession>
    <name>A0A1W1I069_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Nucleotidyl transferase</fullName>
            <ecNumber evidence="2">2.7.7.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0212"/>
    <dbReference type="EnsemblBacteria" id="SLM46384">
        <property type="protein sequence ID" value="SLM46384"/>
        <property type="gene ID" value="NSJP_0212"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0212"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="250" mass="27306" checksum="BA78DF11F1E4220C" modified="2017-06-07" version="1">MKAMILAAGLGTRLRPLTNTMPKPLLPVGGTPLIVWNLLLLRRHGIRDVVINLHYLAPMIQQALGDGSKYGMRISYSHERVLLGTGGALKQVEGSFNGEPILVLNGDTLVEIDLEAVIAFHRTRHAAATLVVRTDPDAASWGLVEMDDDQRIVRITGKGLPSPILAHPRMFAGVHLLHPRLLRDISKGQASSIIDAYLAAIQRGDAVLGFEHQGYWSDVGTPQRYSQAEHDATTGMIQLSSRLPTVQPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0A7</accession>
    <name>A0A1W1I0A7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0240"/>
    <dbReference type="EnsemblBacteria" id="SLM46412">
        <property type="protein sequence ID" value="SLM46412"/>
        <property type="gene ID" value="NSJP_0240"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0240"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="71"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="232" mass="26780" checksum="2D6E1AF81D69D6AC" modified="2017-06-07" version="1">MITIPSWLADFGLSLNRWHYKQRLESSYLRGTSIPSWFDHRIDLYYQWPNNLFWLERGFFARRYMFEGCTVLDLFCGDGFYARNLYATIAGRIDAVDKESRAIAHARAIHAHPKITYWQKDAVKDGLPGASYDVVAWFEGIEHLSEEECTLLLNRLKAAVGEQGTLVGSTPLVAKDQAGKNNWEHQHEFETADEVKSLIGRYFFDVHVEVTVYPELKAGVRRTAYFSARHPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0A9</accession>
    <name>A0A1W1I0A9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0235"/>
    <dbReference type="EnsemblBacteria" id="SLM46407">
        <property type="protein sequence ID" value="SLM46407"/>
        <property type="gene ID" value="NSJP_0235"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0235"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="303" mass="34054" checksum="60BFF245CA39D3FF" modified="2017-06-07" version="1">MNPCPLTISIVTPSYNQAPFLEDAVRSVLTQDDGNLEYVIIDGGSSDGSPDIIRRYQDRLAYWVSEPDKGQYDAINKGFARTTGEIMAWLNSDDKFTPWSFSIVRDIFLRYPEVEWISTLQPLSWNDRGQAVAVSFTGGFNRGSFLRGGNCPSKGSYGRRWIQQESTFWRRSLWERAGGRIETSLGLASDFELWARFYTHADLYGVLAPLGGFRAHGNQKSVLQAEQYLAEAEQVLRQYGGKPCGGIEALVRGMLWKVARHGALLPIPDMMLAASHRVKLTFPTNVITWDGVSEWRIISGFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0C6</accession>
    <name>A0A1W1I0C6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">8-amino-7-ketopelargonate synthase</fullName>
            <ecNumber evidence="7">2.3.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">bioF</name>
        <name evidence="9" type="ORF">NSJP_0269</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42288"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9955"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78846"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="EC" id="2.3.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; biotin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.47" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0269"/>
    <dbReference type="EnsemblBacteria" id="SLM46441">
        <property type="protein sequence ID" value="SLM46441"/>
        <property type="gene ID" value="NSJP_0269"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0269"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008710">
        <property type="term" value="F:8-amino-7-oxononanoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004723">
        <property type="entry name" value="AONS_Archaea/Proteobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00858">
        <property type="entry name" value="bioF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="8">
        <location>
            <begin position="35"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604723-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="386" mass="41547" checksum="97E0E5732C8D357D" modified="2017-06-07" version="1">MFDKLLGDLDAQHLTRHLTEVSTGVAPTVTIDGREILLLASNDYLGLAGHPDIVHAATEATRRYGVGSGASRLVSGTLSPHKDMERALARFKRTASALAFGSGYLANLGAIPALIGRGGLILADRLCHASLIDACRLSGADFRIYRHNDLDHLKALLSRRKAARRTMVVTDGVFSMDGDLAPLAELFGLTRQYDAELYVDDAHGTGVMGQTGRGTLEHFHLEETVPFHMGTLSKAVGCAGGYIAGTETLITFLLNTSRSFMYTTAPPPGIAAAVVAALDIMQREPERRQRLWANRERLCDGLNRLGFTIGASASPIIPIIIGRADRALTFAEQLFSKGVFAPAIRPPTVPESTSRIRVTVTSAHTAEQIDHAVTAFRLAGESIRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0J1</accession>
    <name>A0A1W1I0J1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">trpS</name>
        <name evidence="9" type="ORF">NSJP_0191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0191"/>
    <dbReference type="EnsemblBacteria" id="SLM46363">
        <property type="protein sequence ID" value="SLM46363"/>
        <property type="gene ID" value="NSJP_0191"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0191"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="328" mass="37571" checksum="140E86FC2EF3EF8F" modified="2017-06-07" version="1">MTGRKRVLSGMQPSGLLHLGNYLGALENWKALQDQHECYFFVADWHALSSNYADTSRIREFVRELLIDWLAVGIDPVRSTVFVQSRIPEHAVLHLLFSMIIPVSWLERNPTYKEKQEEIKEKDLSTYGFLGYPVLQAADILLYKPDFVPVGKDQLPHLELTRELARRFNSLYRPVFPEPMELLTKFPKVLGTDGRKMSKSYGNTINLSDTEPVVRQKLKTMMTDPARVRRHDPGNPDVCPVFDFHKIFSPLPVIEQINRECRTAAIGCIDCKKLVADRLVERMTPIWEARTALTKDPSRLEEIVEEGSRKAGEVAKATLHDVTEAMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0P0</accession>
    <name>A0A1W1I0P0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MEDS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46566">
        <property type="protein sequence ID" value="SLM46566"/>
        <property type="gene ID" value="NSJP_0394"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0394"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEDS" evidence="1">
        <location>
            <begin position="17"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="203" mass="23535" checksum="FB6BACD156E490E9" modified="2017-06-07" version="1">MQASGIRGVGDIPWGAHLCAFYRDRLELQHLCASFLAAGLEQGQYCLWITGPPVEEQQAVKALTEAMPTAQQYLDRKQIEIVPYTEWYVRDGRFDRHAVIRRWEEKAIVAAQEGYEGIRITGNPAWLHTEAQWLEFGVYEREVDLALRRQRIIALCTYPKQQCDLDQMGRVMRNHSHAIYRQSLSQFEWHSVTVGDELCQENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0S6</accession>
    <name>A0A1W1I0S6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">grxD</name>
        <name evidence="2" type="ORF">NSJP_0433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0433"/>
    <dbReference type="EnsemblBacteria" id="SLM46605">
        <property type="protein sequence ID" value="SLM46605"/>
        <property type="gene ID" value="NSJP_0433"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0433"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="PTHR10293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="18"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="107" mass="12146" checksum="549951B284289B63" modified="2017-06-07" version="1">MGDPIQDEIQQEIAANKILIYGKGTKTMPMCGFTLETMQFFDKYGYPYELIDVLSQPAKREALTKMTNWPTLPKVFIDGQFYGDTDILDPMAAKGEMEPLLKKAFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I149</accession>
    <name>A0A1W1I149_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="4">4.1.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mvaB</name>
        <name evidence="4" type="ORF">NSJP_0553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0553"/>
    <dbReference type="EnsemblBacteria" id="SLM46725">
        <property type="protein sequence ID" value="SLM46725"/>
        <property type="gene ID" value="NSJP_0553"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0553"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="PTHR42738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="314" mass="33518" checksum="A95F5616F67C718E" modified="2017-06-07" version="1">MSLGNGHNRVARPIRIIEVGPRDGLQNEPAIVPTSAKVSFVNALSRTGAAEIEIGSFVSPHAIPQLADSDEVARKMERLPGVTYSALVPNEKGLERARAAAIEKIAVFTAASETFARRNIKCGVLESIDRFAPLVAEAKRDGMTVRGYISTATHCPFEGAVDPGRVIKVMQRLLHIGIDEISLGDTIGKAAPNDVRRLLDATLPHIERSRLSLHFHDTYGMAVANVLAAWTDYGIEAFDTAAGGLGGCPYAPGASGNVATEDVVYALKASGAILTVDEQQVAAAARQISRALDRPLASRLSRIQTDRTSYEPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1F0</accession>
    <name>A0A1W1I1F0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0645"/>
    <dbReference type="EnsemblBacteria" id="SLM46817">
        <property type="protein sequence ID" value="SLM46817"/>
        <property type="gene ID" value="NSJP_0645"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0645"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="192" mass="20934" checksum="D246340BE1089CB5" modified="2017-06-07" version="1">MMRAFHLKTWLTMTLALLILSCAAGLKGRKEEQLAYFDHLEQDTLALLIKEHPQSEQELADAAGYTIAEKKTVKVPFVGVGDGIGLVREKASDRRSYLQFTQLQFGFGLGVRANRIVVIFQDLNKLREAAAGRWHVGIAAEATAKVGDVGAAGEGGKSDLTEKGYSTYVLTDCCVSASATIRVLRARPYSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1P1</accession>
    <name>A0A1W1I1P1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cysteine desulfurase IscS</fullName>
            <ecNumber evidence="7">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">iscS</name>
        <name evidence="10" type="ORF">NSJP_0571</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0571"/>
    <dbReference type="EnsemblBacteria" id="SLM46743">
        <property type="protein sequence ID" value="SLM46743"/>
        <property type="gene ID" value="NSJP_0571"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0571"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02006">
        <property type="entry name" value="IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="6"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="7">
        <location>
            <begin position="74"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="7">
        <location>
            <begin position="203"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="7">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <note>ligand shared with IscU</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM46743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="406" mass="44166" checksum="C62E0E4170C4BD8B" modified="2017-06-07" version="1">MMKLPIFLDNHSTSPMDPRVLETMLPYFTEKFGNAASRNHAFGWAAEEAIDTARKQIAKLINADAKEIVFTSGATESDNLAIKGVLEMYKEKGSHIITAVTEHRAVLDTVKTLEAKGLATVTLLQVDKQGMVNPEDVRNAITDKTVLISVMLANNEIGSINPIKQIGKIAKEKGVLFHCDATQGVGKIPVDVQDMGIDLMSFSAHKIYGPKGIGALYVRKKNPRVRIAAQMDGGGHERGMRSGTLAVPLIVGFGKACEICGQEMAAESVRLTKMRDRLQSAIMGALEETYLNGHPTNRLPGNLNISFAYVEGESLLMGMKDIALSSGSACTSATLEPSYVLRALGVGTELAHSSIRFGLGRFNTDEEIDYTIKKVIEVVTKLREMSPLYEMAKDGVDLKTVQWAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I245</accession>
    <name>A0A1W1I245_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Guanyl-specific ribonuclease Sa</fullName>
            <ecNumber evidence="6">3.1.27.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_0908</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.27.3" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0908"/>
    <dbReference type="EnsemblBacteria" id="SLM47080">
        <property type="protein sequence ID" value="SLM47080"/>
        <property type="gene ID" value="NSJP_0908"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0908"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="Gua-sp_ribonuclease_N1/T1/U2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="SSF53933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012912927" evidence="5">
        <location>
            <begin position="28"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="152" mass="17133" checksum="4198B6B0C93120A6" modified="2017-06-07" version="1">MMRPFPRGIWSGVIGFALLLSATIATSQPVGPQAEPPGIATPELHGLPNHDGPPPGRTEAASPLRQKTEIPQKAKDLLRTIRERQGMPPPGYAGGRTFHNRERRLPRGLYREYDVNPKIRGRPRDAERIVIEQQTDRAYYTADHYRTFAPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I267</accession>
    <name>A0A1W1I267_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">dtd</name>
        <name evidence="2" type="ORF">NSJP_0934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0934"/>
    <dbReference type="EnsemblBacteria" id="SLM47106">
        <property type="protein sequence ID" value="SLM47106"/>
        <property type="gene ID" value="NSJP_0934"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0934"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="146" mass="15913" checksum="9C427FE32364F4A7" modified="2017-06-07" version="1">MKAVVQRVVRARVEVDGETVGQIREGLLVLLGVAADDTEAAGRSLAEKLQTLRIFSDDRGKMNRSLADIGGSVLLVSQFTLLGNTKNGRRPSFEEAAPPEEAKRLYEFVIHEVRARGVHVETGVFAAHMAVESVNDGPVTFVLETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I268</accession>
    <name>A0A1W1I268_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">cysS</name>
        <name evidence="14" type="ORF">NSJP_0741</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0741"/>
    <dbReference type="EnsemblBacteria" id="SLM46913">
        <property type="protein sequence ID" value="SLM46913"/>
        <property type="gene ID" value="NSJP_0741"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0741"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="13">
        <location>
            <begin position="354"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="265"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM46913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="477" mass="54356" checksum="308E0E70E0FCE026" modified="2017-06-07" version="1">MLTLFNTLTGKQEPFKPLEPNRVRMYVCGVTVYDYCHIGHARSALVFDVLRRYLEHAGYEVEFVKNFTDVDDKIINRARERGISCEAITSEFIEAYYQDMGKLGILPATKEPRATAHIVDIVAMTEKLVKKDLAYQVGGDVYFQVNKYPAYGLLSKRKLEDLLAGARVEVDERKRHPMDFALWKNSKPGEPSWPSPWGMGRPGWHIECSAMSIKYLGETFDIHGGGMDLIFPHHENEIAQSCGTTGKEFARYWIHNGFVQLNREKMSKSLGNFFTIREVFEKSQWSQDVTGEVLRFFLLSTHYHGPLDFSDQALQEAKRALEGFYGLFNRLHEQEGNAAGDIGLDPAIRRTIEGFRTAMDNDLNTPAAIAEFQKLRADINKLLGTGLSTDGRLKARQAFRSLGTVLGLFQLDRWEYSLKADEGQYQLSGEEIEMKLAERRAAKAQKDFKRADQIRSELSSQGIIIEDKPDGTSRWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I291</accession>
    <name>A0A1W1I291_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1653 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0958"/>
    <dbReference type="EnsemblBacteria" id="SLM47130">
        <property type="protein sequence ID" value="SLM47130"/>
        <property type="gene ID" value="NSJP_0958"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0958"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023387">
        <property type="entry name" value="DUF1653-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037135">
        <property type="entry name" value="DUF1653-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07866">
        <property type="entry name" value="DUF1653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1653" evidence="1">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="70" mass="8254" checksum="70B35D7F95C05A27" modified="2017-06-07" version="1">MVEPGRYRHYKGDEYEVVGTARHSETEEEFVVYRALYGARGLWIRPRAMFEETVTVDGKDVPRFRFLAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I295</accession>
    <name>A0A1W1I295_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0945"/>
    <dbReference type="EnsemblBacteria" id="SLM47117">
        <property type="protein sequence ID" value="SLM47117"/>
        <property type="gene ID" value="NSJP_0945"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0945"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032267">
        <property type="entry name" value="DUF4832"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16116">
        <property type="entry name" value="DUF4832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_42" evidence="1">
        <location>
            <begin position="99"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4832" evidence="2">
        <location>
            <begin position="333"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="496" mass="55439" checksum="A8AE8A3AC8AEF6CE" modified="2017-06-07" version="1">MKEKGSGLPTSGALVKTSRSFPILLTIWYLLLSLATSIDVVTAGEPAAATDDQRASPPLVTVYPLQIDDILYNPGMGFADFHFGFDHPPSRTQYPRSTVAYFRWSWADLEPVEGEYNFQLVDDVIAQARAKGETLAFRIMTEYEDGSPAWLLDKGVASVSVSGGTFPDYNDPRFLEAHERLLKALGARYGDSPAIDHVDIGSIGCWGEWNMACCLGVEARCKQLYATEDNQRKITDWYFQYFPAVPLVALVGGQLAYATAQGAGWRGDCFGDYGYFRSDWNHMDHVYARKLRDPVVAEAWKHGPIEFEVCGVMQDWIDKGFNLDLILQKGLEWHVSVLNAKSEPVPESWRPRIEEFQKRLGYRLVLRELTHTVETIPGGIVTVRSQWNNVGVAPMYHDHPLAYRLRSNEGAVVAQWESEARPMDWLPGSSIQVEDAHPLSEDLPAGRYHLDVAVLSEDGSTADVELAIAGKRADRWYPVSALTVRREQARDGAPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2A0</accession>
    <name>A0A1W1I2A0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable GTP-binding protein EngB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">engB</name>
        <name evidence="10" type="ORF">NSJP_0929</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for normal cell division and for the maintenance of normal septation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0929"/>
    <dbReference type="EnsemblBacteria" id="SLM47101">
        <property type="protein sequence ID" value="SLM47101"/>
        <property type="gene ID" value="NSJP_0929"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0929"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0717">Septation</keyword>
    <feature type="domain" description="EngB-type G" evidence="9">
        <location>
            <begin position="26"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="204" mass="22468" checksum="8A85BEC04297C3F9" modified="2017-06-07" version="1">MVDTMKILTAEFIRSCVGPEQFPNGGLPEIAFVGRSNVGKSSLINSLLQRKSLAKVSRTPGKTRAVNVFSVVTGDVQLARFMIVDLPGYGYAKVSKSIRAQWGPLLEAYLTDREEVRIVVLLVESRVPAAQDRATIEWLLSIGHLPVVVATKVDKLKPSERVAGLRRLGAELGLDDRLPVIAYSSTTGEGRDRLWTVLKERTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2B1</accession>
    <name>A0A1W1I2B1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0978"/>
    <dbReference type="EnsemblBacteria" id="SLM47150">
        <property type="protein sequence ID" value="SLM47150"/>
        <property type="gene ID" value="NSJP_0978"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0978"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="47"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="348" mass="38401" checksum="FE3B571A4117E0F1" modified="2017-06-07" version="1">MSSGLKLILAVMSATVMLTAGLWLACGVLGGTARGKRVAKALNIPRPAVIAHRGASHLAPESTVPAYLMARELGADYLEIDLQRTKDGTLVVVHDDDLSRTTNVAEVFPGREKDTIDTFTFAELAQLDAGSWFNRTFPDRARGSFKGLRILRMDEVIALAESGTRRPGLYIETKAASRFPGIEEQLVGALRQRGWIEDSEGPPSGRVIFQSFEPNSLVRLKSLAPRVPRLLLLDELMVAREGLDSLMKIASDVGSGVGTWGVRWAFSPYWSLTAAPKRYLTTWPWHTGQAHEAGLFVHPWTINERWEMWMVTLSGADGFFTDRADVALAVVGKPGRDEPQTLWNRIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2B8</accession>
    <name>A0A1W1I2B8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Carboxylesterase</fullName>
            <ecNumber evidence="2">3.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0988"/>
    <dbReference type="EnsemblBacteria" id="SLM47160">
        <property type="protein sequence ID" value="SLM47160"/>
        <property type="gene ID" value="NSJP_0988"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0988"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080030">
        <property type="term" value="F:methyl indole-3-acetate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="239" mass="25751" checksum="1E13ACFEB9C84643" modified="2017-06-07" version="1">MREERAGGLRIRLTGGTDGRGGGSGPAVILLHGFGAPGNDLVPIGDALAVPPGTRFIFPEGPLSLSFGYGDSRAWWLIDMARLEADRAAGRVRDLSTEVPRGLPQARAALEQLLVELPRVLPVDYKKTVIGGFSQGAMLTCDLAMRTAHPFAGLVQLSGTLLARQEWRPSVAKRSGFPVFQSHGTQDPILPYGMAERLRDALTQAGLAVAWHSFRGGHEIPEPVMRQLSAFLTNLLNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2C7</accession>
    <name>A0A1W1I2C7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47158">
        <property type="protein sequence ID" value="SLM47158"/>
        <property type="gene ID" value="NSJP_0986"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0986"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="56" mass="6151" checksum="4E8A0BFAF5E9F158" modified="2017-06-07" version="1">MLTLIHRECGGPALETNTAVGEVCALPVDRFPFPCFTCLEDILDESEVRLSEELGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2J5</accession>
    <name>A0A1W1I2J5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1029"/>
    <dbReference type="EnsemblBacteria" id="SLM47201">
        <property type="protein sequence ID" value="SLM47201"/>
        <property type="gene ID" value="NSJP_1029"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1029"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="227" mass="25755" checksum="B157EFC6F9C4420D" modified="2017-06-07" version="1">MPPGKIVVLFDVDNTLLDNDGVTEDLRRYLEQEVGAEPQKRYWVLFEELRQELGYADYLGALQRYRIEHPRDPHLLAVSHFLIQYPFADRLYPGALDVIAQAKRAGTAVILSDGDVVFQPRKVERSGLHHAVDGNVLIYIHKERELEDVERRFPADRYVLIDDKVRILSAVKRVWGSRVTTVFPRQGHYALDLQDVAQFPVPDVTVSAIGDLLVGDRFARVLSGAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2K5</accession>
    <name>A0A1W1I2K5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47222">
        <property type="protein sequence ID" value="SLM47222"/>
        <property type="gene ID" value="NSJP_1050"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1050"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010717145" evidence="1">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="161" mass="17549" checksum="73F54F51E4D8801D" modified="2017-06-07" version="1">MNSRRRLVLCGVISLLLSFLTACVSVRVEPLTHEVYPPKKNSESLQWLESEPDAPHVKLARIIATSQSADEDELREKILACAATLGADAVIMGKSDVLETVGAGSAPESTMGPAGGSFGGWWPFYYDRWSFAQSPTDETGFTEYLSGTAIRYVNERSLESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2P3</accession>
    <name>A0A1W1I2P3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47262">
        <property type="protein sequence ID" value="SLM47262"/>
        <property type="gene ID" value="NSJP_1090"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1090"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021327">
        <property type="entry name" value="DUF2934"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11154">
        <property type="entry name" value="DUF2934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="81" mass="8972" checksum="D0ADD4EA223AFE5B" modified="2017-06-07" version="1">MRVRVDKGKPARKVSASTTSSPLISDKSLAIHGESVSPTGNDLHVRIAKRAYEIHAERGYLQGHALDDWLDAEREVLKHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2P6</accession>
    <name>A0A1W1I2P6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cold shock protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1073"/>
    <dbReference type="EnsemblBacteria" id="SLM47245">
        <property type="protein sequence ID" value="SLM47245"/>
        <property type="gene ID" value="NSJP_1073"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1073"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="1">
        <location>
            <begin position="2"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="46" mass="5158" checksum="9219DDC8BBEBDA3F" modified="2017-06-07" version="1">MYFHRNALQGLSFQDLDDGSEVLFNVEKGRKGPQATAVHPMPAMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Y4</accession>
    <name>A0A1W1I2Y4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47354">
        <property type="protein sequence ID" value="SLM47354"/>
        <property type="gene ID" value="NSJP_1182"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1182"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021383">
        <property type="entry name" value="DUF3015"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11220">
        <property type="entry name" value="DUF3015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="157" mass="17028" checksum="B4B37B878474D27E" modified="2017-06-07" version="1">MERGRYKGRGYWISLWGLAAALSGCDATVELTKAPFDATSDLTDGISNASSEFLEPTKEFSSSTTPGSVAGVNRAKAKRKLEVFTLYTRDNLRTDISKGQGEYLSSLASIAGVPQDQRGEFGRHMQQSYATLFDETLAAKESTARLVDAAWVAGYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Y6</accession>
    <name>A0A1W1I2Y6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1196"/>
    <dbReference type="EnsemblBacteria" id="SLM47368">
        <property type="protein sequence ID" value="SLM47368"/>
        <property type="gene ID" value="NSJP_1196"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1196"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008023">
        <property type="entry name" value="DUF748"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05359">
        <property type="entry name" value="DUF748"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="528" mass="58573" checksum="1B0FBD9C39C97F82" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I318</accession>
    <name>A0A1W1I318_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">glyA</name>
        <name evidence="10" type="ORF">NSJP_1220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1220"/>
    <dbReference type="EnsemblBacteria" id="SLM47392">
        <property type="protein sequence ID" value="SLM47392"/>
        <property type="gene ID" value="NSJP_1220"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1220"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="14"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="422" mass="45491" checksum="1F9353EBDF57641F" modified="2017-06-07" version="1">MSMKDAVGSLDALHAADPEVYAAIDAEEERQRHKLLLIASENFASPAVLAAQGSLMTNKYAEGYPGKRYYGGCQHVDTVEDLAIQRCKQIFGAEHVNVQPHSGSQANMAAYLSVLKPGDTILGMDLAQGGHLTHGSKVNFSGSIFRAFSYGVDRRTETIDYEAVQKLAEECRPRMLVVGASAYARTIDFPRFAQIAKSVGAYLMVDIAHIAGLIAAGLHPSPVPHADFVTTTTHKTLRGPRGGVVMCKAEHAKAVDKFVFPGMQGGPLMHVIAAKAVAFKEALSPAFKRYQQQVVTNAKVMAQGLLDRGYRIVSGGTDTHLMLVNLTNKNITGKEADAALDAAGIIVNKNAVPYDEKPPAIASGIRLGTPIVATRGMKEAEMKSIVELIDTVLQHREDPAALETVRAKAKELCSRFPIFHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I350</accession>
    <name>A0A1W1I350_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">nrdR</name>
        <name evidence="10" type="ORF">NSJP_1219</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NrdR family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1219"/>
    <dbReference type="EnsemblBacteria" id="SLM47391">
        <property type="protein sequence ID" value="SLM47391"/>
        <property type="gene ID" value="NSJP_1219"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1219"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ATP-cone" evidence="9">
        <location>
            <begin position="49"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="7">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="154" mass="18291" checksum="1AB3D98DD51EBC94" modified="2017-06-07" version="1">MKCPFCDDVEDKVVDSRMAKEGELIRRRRECLGCKRRFTTYERVDEILPVVVKKDGRREAFDRAKILSGLKKACEKRPISTVTIESVTDRIEKRIQEMGETEIESRIVGEELMKELHQLDQVAYVRFASVYREFKDIDQFMDELRTLAQQRRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I375</accession>
    <name>A0A1W1I375_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47458">
        <property type="protein sequence ID" value="SLM47458"/>
        <property type="gene ID" value="NSJP_1285"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1285"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="151" mass="16984" checksum="9D3AB925D0AF46A1" modified="2017-06-07" version="1">MRTHLSRQAAASGVEGDRRRIRIRRKTEPEDPAGAIPTRQTKEFWPISGWLVVGPSHVTLNASCGCFPRNAPVLHNNPRYPLTCRVTWLRSVDTLQAAEAAHSSSVEHQLTTKFRIVVLVSPPVEYACGRISSTETQYVIMEHLPKWCEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3H4</accession>
    <name>A0A1W1I3H4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S58</fullName>
            <ecNumber evidence="2">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dmpA</name>
        <name evidence="2" type="ORF">NSJP_1374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1374"/>
    <dbReference type="EnsemblBacteria" id="SLM47546">
        <property type="protein sequence ID" value="SLM47546"/>
        <property type="gene ID" value="NSJP_1374"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1374"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="PTHR36512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="412" mass="43337" checksum="2AC554A0D7ECC6EF" modified="2017-06-07" version="1">MTRPSSKIRVLSLSIAVIVPAWLAAVGCVSILAAESDEPRLRARNLGIVIGSHEPGPLNAITDVSGVKVGHRTLISGSGPLKPGVGPVRTGVTVIIPRDDVWHRKVPAGFFVLNGTGETTGLAWIGESGFLEYPIALTNTLNVPRVADGVMSWMIRQYPEIGITDDTLTPVVAECDDGRLNDIQGRHVSEADVALALDDASTGSVREGTVGAGTGMVSYGFKGGIGTSSRRLTVEEGGYTVGVLVNANHGRRNELIVDGVPVGRFYDAHAQTSEKPNGPLADIAVPGAGEGSIITVIATDAPLDSRQLTRLAKRAALGLARTGATARHGSGDFMVAFSSAGVIPHYPKERTYQLTHLADTHLNPLITATIEATEEAVLNALTTATTVVGRDDRRADAISLSRLRTLLQEHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3J7</accession>
    <name>A0A1W1I3J7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47576">
        <property type="protein sequence ID" value="SLM47576"/>
        <property type="gene ID" value="NSJP_1404"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1404"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="204" mass="21853" checksum="7FFD18FE6BE3833D" modified="2017-06-07" version="1">MVKPWTGFVILYVLLLGGCAQPPADQITSAEQAIKDAQQSGAATYIADEYAKLEGGMAAIRKEVADQEAKFALFRDYGKVDQLVATVKTDAERVKTDSLKKMEEAKMAAVQAHHAAADAVKHAADLIAAAPAGKDRAALESIKTDAEALKASLNDVQMMIDKSDYLTAQTKAKAIQEKSQALSHEVETALAKIGKAKPVRTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3P7</accession>
    <name>A0A1W1I3P7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Outer membrane protein, OmpA/MotB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_1337</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1337"/>
    <dbReference type="EnsemblBacteria" id="SLM47509">
        <property type="protein sequence ID" value="SLM47509"/>
        <property type="gene ID" value="NSJP_1337"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1337"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="273"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="355"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="63"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="174"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="393" mass="42756" checksum="630CD3692E3B6F52" modified="2017-06-07" version="1">MQRERLLAIILGLLVTVWAANDTGAEWYNQEEAPNDTSSRALNEMRAKGKVAAPAEDPRNLRIAELERMVAERDKEIARLRELSGDVNQAKGRSSDLERQLAERDRMLTDRDRELATLRSGAGDSEKMAQQLSSTQRELELSRTHTADLERQMSGLSASSGAEIAALQAGAGDRDKLAAELAASKQRTAELEAQCAALGSAAGEKDKLTAELAAAKQQTANLEKQLADRDRELAGLRGDLSAEMAKLKEAERGLIRALRPQIDKKNITVDLNNERLLINLASGYLFDSGDDRLKPDGTEALKQVGAILKEFPEYKVSVDGHTDNRPIRGALKNKFPSNVELSEARARNAAEALSSGGFSGASTAGYSDTRPVAPNTTDAGRAQNRRVEVRVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I436</accession>
    <name>A0A1W1I436_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.163</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ubiE</name>
        <name evidence="4" type="synonym">menG</name>
        <name evidence="6" type="ORF">NSJP_1594</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47766">
        <property type="protein sequence ID" value="SLM47766"/>
        <property type="gene ID" value="NSJP_1594"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1594"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="132"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="260" mass="28566" checksum="FE560E452A7D69B9" modified="2017-06-07" version="1">MLSVEESVTQSPPGNDAEARTISTWSGEAREQAVQRMFTAIAGVYDLNNTLLSFGLHHRWKKRTARCVPPVEHGTALDVGAGTADLALLLEPRMGAKGRVVASDLNHAMLAEGLKKVTAKGLAGKVTCLQANAEHLGFADDIFDAVTTGFCMRNVGNLAQAVREIRRVMKPGGTFVCLEFSRPVFGWLRALYDWYSFTLLPWIGTKVAHDRTGVYEYLPASIRTFPDQERLCVILKEAGFREVSYRNLSGGIVAIHIAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I447</accession>
    <name>A0A1W1I447_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1602"/>
    <dbReference type="EnsemblBacteria" id="SLM47774">
        <property type="protein sequence ID" value="SLM47774"/>
        <property type="gene ID" value="NSJP_1602"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1602"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="57"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="879" mass="96179" checksum="52C3E6FA20448CFB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I478</accession>
    <name>A0A1W1I478_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47827">
        <property type="protein sequence ID" value="SLM47827"/>
        <property type="gene ID" value="NSJP_1655"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1655"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013388890" evidence="1">
        <location>
            <begin position="23"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="113" mass="12506" checksum="FBBE403DA07C27CB" modified="2017-06-07" version="1">MQILVVFWLVAGLLLTRTTVLAQDATIERVLRTQVFNKTFEGFEYYHVTIEEDQPQADGSREVIAVASGKFLNNTVRLKALFLIVDEQVIGGQILDNTGLPPCLAPGESRSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4B8</accession>
    <name>A0A1W1I4B8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1653"/>
    <dbReference type="EnsemblBacteria" id="SLM47825">
        <property type="protein sequence ID" value="SLM47825"/>
        <property type="gene ID" value="NSJP_1653"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1653"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="82" mass="9276" checksum="6E55D9A74BE63C31" modified="2017-06-07" version="1">MDAPLLRVHEAAALLKVSKWTVYRWIEEGRLRATKIGRGSLRVFRVSLTALIDENRTDSLSVPAKHRGNVVKLRAVAAKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4E9</accession>
    <name>A0A1W1I4E9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47884">
        <property type="protein sequence ID" value="SLM47884"/>
        <property type="gene ID" value="NSJP_1712"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1712"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010718050" evidence="1">
        <location>
            <begin position="24"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="171" mass="19609" checksum="F1A22463B4D91F10" modified="2017-06-07" version="1">MKQRSGHLFLLAFVFLWFPNALHAVPMTKDPKGFRDIAWGSSLAERPDLKVKQEGDHLRDYEFSRDAPSFGGIPVESVRLTSVDEQFARVTIRYKGDQTHKRILVYLEEEFGPVERLPGQMVRGLNQQYNWRGTDSEINVTYQAATERGFIFIDSRSLAPLFNDQIADTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4J8</accession>
    <name>A0A1W1I4J8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Dimethylargininase</fullName>
            <ecNumber evidence="1">3.5.3.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.3.18" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1571"/>
    <dbReference type="EnsemblBacteria" id="SLM47743">
        <property type="protein sequence ID" value="SLM47743"/>
        <property type="gene ID" value="NSJP_1571"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1571"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016403">
        <property type="term" value="F:dimethylargininase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="266" mass="30169" checksum="0A3486C500045568" modified="2017-06-07" version="1">MSRLLVCPPDYFAVDYEINPWMHRSNVVNTERAIAQWHRLVHVLETELGATLERMKPVSGLPDLVFTANAGVVFEGKAVPSRFRYPERRPEETHFEAWFREHGYGVTTLDEGLYFEGAGDLLGFPDGWFGGYRQRSDIRAFPVLSDLFGKEILPLELVDGRFYHLDTCFCPLSGGELLYYPPAFDDYGRATIKERLDGRRRLEVPEEEALKFACNAVCIGRQVVLPENCPKTMTLLESQGYQPYSLPLDEFMKSGGSAKCLTLALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4N4</accession>
    <name>A0A1W1I4N4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6 7">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">murF</name>
        <name evidence="11" type="ORF">NSJP_1729</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6 7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1729"/>
    <dbReference type="EnsemblBacteria" id="SLM47901">
        <property type="protein sequence ID" value="SLM47901"/>
        <property type="gene ID" value="NSJP_1729"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1729"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="121"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="9">
        <location>
            <begin position="332"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="123"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM47901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="480" mass="51742" checksum="50065327144BA45C" modified="2017-06-07" version="1">MALFTIEELREVISVKVLAGEAAPSAKRRIRNIGTDSRSIGRGDLFVALQGERFDGHEFVATAFAQGAIGAIVHDQYRPPVSKRQDRRPVPFLLGVRDPLFAYQQLAMHHRSRFEIPVVAVTGSNGKTTTKEMTAAVLGHRWRTLKTEGNYNNRIGVPHTLFRLTKRHQAAVIEMGVDARGQTTRLCEIVRPTIGIITNIGPDHLEFFGSMEGSAQAKAELLDLLSADGTAVLNADDPYFDYLASRARSRVVSFGLSDKADVRATRVTSDVKRGTKFDLLLPGKGRPIGVTMKVHGTHNVLNALAAAATGFALNLSGAIISEGLATFRPAAMRSQIVAHHGVQIINDCYNANPASMKAAIELLATWTPSRARVAVLGDMLELGTQTKALHREVGAYLARRDVSRLIACGSLGREIAEGARQGGMSGTAVAEVGDAVAAADLLRAEVRQGDVVLVKASRGMKMEQVVQRLTGMRAVTKEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4T3</accession>
    <name>A0A1W1I4T3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.129</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ftsI</name>
        <name evidence="4" type="ORF">NSJP_1727</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.129" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1727"/>
    <dbReference type="EnsemblBacteria" id="SLM47899">
        <property type="protein sequence ID" value="SLM47899"/>
        <property type="gene ID" value="NSJP_1727"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1727"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PBP_dimer" evidence="3">
        <location>
            <begin position="53"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="239"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="570" mass="61878" checksum="08B75CE57FE3A3D4" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4V3</accession>
    <name>A0A1W1I4V3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase (Caspase-1 like protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1885"/>
    <dbReference type="EnsemblBacteria" id="SLM48057">
        <property type="protein sequence ID" value="SLM48057"/>
        <property type="gene ID" value="NSJP_1885"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1885"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="324" mass="35290" checksum="4665133DD897704D" modified="2017-06-07" version="1">MRKALVVGINFYSHASELYGCVDDAHAVKSALERNSDGTVNFAVKLLTGTGPSDRVLRSQLREHIQDLFSDESETALFYFAGHGHVEATGGYLIASDSKTGDEGIPLGDVLTFANRSAARNRIIVLDSCHSGIAGTNPSAPTNAEIKEGTTILTASTADQYANEKNGAGVFTSLFVDALNGAAGNLVGDVTPGSVYAHIDQSLGPWDQRPVFKTNVKSFVSLRKVQPPISLIELQRITEFFPFPGFEFKLDPSYEPERQSQDSTIPIPNPVNTAKFAILQKYNRVNLVVPVDAPHMWHAAMSSKACKLTVLGEHYRRLVEQNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4V9</accession>
    <name>A0A1W1I4V9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48044">
        <property type="protein sequence ID" value="SLM48044"/>
        <property type="gene ID" value="NSJP_1872"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1872"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="102" mass="11545" checksum="17113C66E4642524" modified="2017-06-07" version="1">MKALLNVKELASALGVSVKSVQRAYRKQEIPVQCLCRMALFDLDDVRRAMTRNGKRRFDTSEVKADKERGAAGGASRRRTGSNSPRTVKRGRNFQKDPRRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Y4</accession>
    <name>A0A1W1I4Y4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 17" type="primary">metK</name>
        <name evidence="17" type="ORF">NSJP_1819</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1819"/>
    <dbReference type="EnsemblBacteria" id="SLM47991">
        <property type="protein sequence ID" value="SLM47991"/>
        <property type="gene ID" value="NSJP_1819"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1819"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="112"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="230"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="227"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SLM47991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="382" mass="41793" checksum="44AA0179DF1860C7" modified="2017-06-07" version="1">MRNNYLFTSESVTEGHPDKIADQISDGILDAIIAQDKFSRVACETILTTGIAFVAGEISTKAYVEIPDIIRDVIKDVGYTDASWGFDCNTCSVLTAIHQQSGDIAMGVDSGGAGDQGLMFGYATNETSELMPMPIVLAHRLTRRLAEVRKKNILPWVRPDGKSQVTVEYRNGKPVRIDTIVVSTQHSPDVTNKQIERGIMEKVIKPIMPKGLYDPTSVKHHINPTGRFVVGGPMGDTGLTGRKIIVDTYGGHGSHGGGAFSGKDPTKVDRSASYMARYIAKNLVAAGLADKCEVQLAYAIGVADPVSVLVDTKNTEKVSVDNLDKLVRKHFPMTPRGIIEHLKLRRPIFRKTAAYGHFGRSEPEFTWEKTDKAKVLRKEAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Z2</accession>
    <name>A0A1W1I4Z2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carbon starvation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cstA</name>
        <name evidence="11" type="ORF">NSJP_1721</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1721"/>
    <dbReference type="EnsemblBacteria" id="SLM47893">
        <property type="protein sequence ID" value="SLM47893"/>
        <property type="gene ID" value="NSJP_1721"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1721"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025299">
        <property type="entry name" value="CstA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003706">
        <property type="entry name" value="CstA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02554">
        <property type="entry name" value="CstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13722">
        <property type="entry name" value="CstA_5TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="CstA" evidence="9">
        <location>
            <begin position="33"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="CstA_5TM" evidence="10">
        <location>
            <begin position="450"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM47893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="668" mass="71179" checksum="3225EA5EF4EF6AA2" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I545</accession>
    <name>A0A1W1I545_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48134">
        <property type="protein sequence ID" value="SLM48134"/>
        <property type="gene ID" value="NSJP_1962"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1962"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="65" mass="7503" checksum="CAF2D0878F307630" modified="2017-06-07" version="1">MLPSIRRIVVEGGKESMPSLIRQLTTPEREPKTFFITKTQWRIIEASTRSVKILGHLDYIIYSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I555</accession>
    <name>A0A1W1I555_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Na_H_Exchanger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1972</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48144">
        <property type="protein sequence ID" value="SLM48144"/>
        <property type="gene ID" value="NSJP_1972"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1972"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="9"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="400" mass="42361" checksum="FDC3F6F09669A09E" modified="2017-06-07" version="1">MESVFFTVALWLALAVVSSLIASRLRLSIALIEICVGTLAAAALSLFGSTALLAADAEWLRFLAASGAVVLTFLAGAELDPDVLRLKLAEVSVVGLIGFAAPLVGTAAAAHYVLGWNADASWLCGIALSTTSTAVIYAVMLDTGFNKTEFGKGMLGACFVNDLSSVIALGLLFAPLTYKTFVFVAGTVIVLGTLPYSTAWLTTHFAFRTAAIRTKWVMLVLFGLGSLALWSGSEAVVPAYLVGMVLAGSAARDAHWMRRLRTLTVGFLTPFYFLRAGMLVSLPALLTAPLVFVILLATKMVSKILGLYPVIGAFRTDPRERWYYTLLMSTGLTFGTIASLYGLSHGLVTPEQYSYIVAAVIASAVVPTLIAGLFFLPVHLLPAGDQPAKPPRINGLSNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I577</accession>
    <name>A0A1W1I577_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase S1C, HtrA family</fullName>
            <ecNumber evidence="4">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1980"/>
    <dbReference type="EnsemblBacteria" id="SLM48152">
        <property type="protein sequence ID" value="SLM48152"/>
        <property type="gene ID" value="NSJP_1980"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1980"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013003677" evidence="2">
        <location>
            <begin position="28"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="266"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="376" mass="39424" checksum="6C14D34816D32D82" modified="2017-06-07" version="1">MTRPAVHPSGPIICLAALLSCAPSVQAADWGKPLGATYDGPEGKARAVTPAPLELAADERATMAVFERVTKSVVFIANTAIQRDPWSFDLLEAPQGSGSGFVWNKQGHIVTNFHVVYGASSIKVTLADRSEYKAVLIGADPDHDLAVLQIQATDDALSPITVGSSNDLRVGQKVLAIGNPFGLDHSLTTGVVSALGRTIKSLSNRTIEGVIQTDAAINPGNSGGPLLDGTGRLIGVNTQIVSPSGAFAGIGFAVPVDTVNRIVPELIKHGKLIRPGLGVSLVPDAMAKRWGVKGLIIGKVSRGGAAERAGLQGARETMPGRVELGDVIVSVNNRPVSTVDELMDVMEDHKVGDRVTVDILRNNRRQSVTVTLQAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5L0</accession>
    <name>A0A1W1I5L0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, molybdopterin binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2136"/>
    <dbReference type="EnsemblBacteria" id="SLM48308">
        <property type="protein sequence ID" value="SLM48308"/>
        <property type="gene ID" value="NSJP_2136"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2136"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_molyb" evidence="2">
        <location>
            <begin position="57"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="214" mass="24844" checksum="C569A31DA742B249" modified="2017-06-07" version="1">MDDTNRLTQKKEQWAKARRGGEEREVFHEGNDRLPPGQHLVETFPVLDLGFKPDIPHSEWTLSLGGFVTTPVIWTWEQFQAQPRFRDVSDFHCVTSWSRYDNEWEGVSFKHILSVVAPLSLAKFVLFKSYDDYTTNLPLEACNDDDVLLASKWNGAPLTREHGGPVRVIVPKRYAWKGAKWVKEITFLDKDEKGFWEVRGYSNTALPWLNDRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5M7</accession>
    <name>A0A1W1I5M7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component system, chemotaxis family, response regulator CheB</fullName>
            <ecNumber evidence="3">3.1.1.61</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.61" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1961"/>
    <dbReference type="EnsemblBacteria" id="SLM48133">
        <property type="protein sequence ID" value="SLM48133"/>
        <property type="gene ID" value="NSJP_1961"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1961"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheB-type methylesterase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="215" mass="23186" checksum="132368ECB0E17AB7" modified="2017-06-07" version="1">MTLPLVKKRKHVFHPRTVNQNGVKRDIIVVGASAGGIMVLQQIFSELPDDMSVVIAVVLHRGASPGQLASVLSAPSKWPVIEPENGTLMKPRNVYLAPADHHLCFENGRFSVDRGPKEHGTRPAVDPLFRSAAAQYRHRVVALVLTGCGDDGVGGSISIKAHGGICLAQDPDESYMPSMPQNAIRYDDIDQILSVSDMVPVLRSLANGEEVRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5T9</accession>
    <name>A0A1W1I5T9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sugar dehydratase/epimerase YfnG (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48377">
        <property type="protein sequence ID" value="SLM48377"/>
        <property type="gene ID" value="NSJP_2205"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2205"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="337"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="451" mass="51859" checksum="C89F0FE30E3CC48B" modified="2017-06-07" version="1">MTNFWTDKTALVAGATGFLGGWLVRRLVSRGAHVVSLVRSHKANSQFFMESLDNQTWVEWGSVADQHVIERIFDRHQVDVFFHAAYGADVHRVLKEPLECFKSSALSTWQILEFLRQHRPQCISVISSTDKVYGRQEIPYREDMALQPLHPYESAKASQDHAAQSYGKIFKCPVAVTRCGNYFGGYDFNFTRLIPGVVRSIMQGQIPTLRSNGRFTRDFLYIGDAVDVQLLLAERLSENPELYGEAFNFSYGERIEVRDIVQHICRMLDSPDEPRLGEDSTTEIPHMELSSEKAKRLLDWKPSYGFMQGLERTVRWYQDYFASQAKTGTAHPSRRGGEDRVVHAASPAAHEAMIVRDADGTIRYWSREAERIYGWTPQEVLGTNTHHLFETKFPEPLQNIEREMQEKNAWRGQLIHKRRDGSRITVNSRWSAQQNPDTRSFTVIELNEKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5U7</accession>
    <name>A0A1W1I5U7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trehalose synthase</fullName>
            <ecNumber evidence="2">2.4.1.245</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">treT</name>
        <name evidence="2" type="ORF">NSJP_2226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.245" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2226"/>
    <dbReference type="EnsemblBacteria" id="SLM48398">
        <property type="protein sequence ID" value="SLM48398"/>
        <property type="gene ID" value="NSJP_2226"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2226"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102986">
        <property type="term" value="F:trehalose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="209"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="399" mass="44579" checksum="FB48A3891961B85C" modified="2017-06-07" version="1">MAPGLDEYRNIAPKGTVDFLYRLSEQVAGRSFVHVSAGRYGGGMAEVLRRLVPMMNTLGIDARWEVLAGDQEFAQATKRLMNALQGQDEQLTEQMQSVYLKINQRTAQTLNLDADLVMVHDPPPAALIEHRKGGTWFWRCYLDIAKPRQESWSFLRRFIVGYDAAVFSLPGFAHRLPIPQFLISPSIDPLSTKNRELTRVETNQILLRLGIPRDKPILLQLARFEWSKDPIGVVKAYRLVKKHHDCRLVLAGSGVTHDSEGEAVLAQVLEAAGSDPDIHVLQLPPEADLEINALQRAATIVFQKSIREGFNVAVAEAMWKGRPVIGSIAGGIAAQIVDGVTGHTVHSVEGMAFRTRLLLNNPSLMQRMGGAGREHVRRNFLVTRHLSDFLTLMKLFEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I624</accession>
    <name>A0A1W1I624_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48456">
        <property type="protein sequence ID" value="SLM48456"/>
        <property type="gene ID" value="NSJP_2284"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2284"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="7"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="116" mass="13199" checksum="1248AEE11180FE0F" modified="2017-06-07" version="1">MDTVPHEQRRHVRYPVEYAGSFSAKDVHTNGIILNLSISGCRALSDVPVSGGELGVSIEVPRRQHPLEILTATVRWTRGAEFGVEFVRIEPDQQRRLRELIQENEADLALRIWQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I644</accession>
    <name>A0A1W1I644_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48464">
        <property type="protein sequence ID" value="SLM48464"/>
        <property type="gene ID" value="NSJP_2292"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2292"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="128" mass="15186" checksum="EF4DAC184487A4BD" modified="2017-06-07" version="1">MTPWRRWISIGYFASAFMAVIYVPWVQHDTSYQFYEYAFIFNPPQFRAEIAYGIVILEILAISLVASALFIFEDILEPRVSQWIAEAQKPPPPLRPLDPLWEKNWENVGRRLGTFYRTLRQKSRTKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I647</accession>
    <name>A0A1W1I647_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">secE</name>
        <name evidence="8" type="ORF">NSJP_2326</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2326"/>
    <dbReference type="EnsemblBacteria" id="SLM48498">
        <property type="protein sequence ID" value="SLM48498"/>
        <property type="gene ID" value="NSJP_2326"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2326"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33910">
        <property type="entry name" value="PTHR33910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="64" mass="7302" checksum="58E84A28170D441F" modified="2017-06-07" version="1">MFKRMIESVKTFLTDVRTELKKVSFPTRAETIGSTTVVIVFCVLMSLYLSVIDSFLVWLVGKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I655</accession>
    <name>A0A1W1I655_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48492">
        <property type="protein sequence ID" value="SLM48492"/>
        <property type="gene ID" value="NSJP_2320"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2320"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="281" mass="30741" checksum="8FA7E4AB8FD5C904" modified="2017-06-07" version="1">MGKTPYGAQQRSLAELMLAVAGESVTVMKKNAPEQAMKLKRQDEWGLYLEFLKVMFNLTDRISAFHIPIKDQPEFMNGLEDAVTIQLKTVLEPAFGSGVDQSEIMMTIGGAVAESRQLYERYRFSIAEDSKAKNEMFDVFGGRVAEALGVSGHPQITSAATLCASAAVPAITAILQGDAPPMSTGMAVQPTSASMTHMETASAPQNPTGNEIKLISVMSTVSGEEVETRWGLHPRFRQDLTQEEVQQLTKLMNRVAKILGERYASVAFSDEWTSWHKAGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Q4</accession>
    <name>A0A1W1I6Q4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48692">
        <property type="protein sequence ID" value="SLM48692"/>
        <property type="gene ID" value="NSJP_2525"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2525"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="80" mass="8913" checksum="8DDB345AD7CDD54A" modified="2017-06-07" version="1">MEIGDRLLFMEICVNLLIRKAVPLPSCPARDEQKPADWLQRALVYKPGRGPNISLTPRPEPAETGSLPVRLLMPPHSINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6S1</accession>
    <name>A0A1W1I6S1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine/isoleucine/valine transporter subunit ATP-binding component of ABC superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">livF</name>
        <name evidence="5" type="ORF">NSJP_2387</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2387"/>
    <dbReference type="EnsemblBacteria" id="SLM48559">
        <property type="protein sequence ID" value="SLM48559"/>
        <property type="gene ID" value="NSJP_2387"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2387"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017780">
        <property type="entry name" value="ABC_transptr_urea_ATP-bd_UrtE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03410">
        <property type="entry name" value="urea_trans_UrtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="236" mass="26017" checksum="C04D1BA2422674DD" modified="2017-06-07" version="1">MLELSHINAYYGESHILRNVSFAVSPGEVACLMGRNGVGKTTTLKVITGLLAVRSGNLKFDGADVTKLPTDRRARRGLAYVPQGREIIPHLTVRENLQLGFWARAEAPGRGVEREAFDEVYQLFPKLTHILHRPGGVLSGGEQQQLAIGRALLSCPKLLLLDEPTEGIQPSVVDQIEDVIIQFKNSRRFAILLVEQGLHFAARLAEKYVVMAKGAVVAYGRSDELNADMVRQHLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6S3</accession>
    <name>A0A1W1I6S3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48700">
        <property type="protein sequence ID" value="SLM48700"/>
        <property type="gene ID" value="NSJP_2533"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2533"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="118" mass="13609" checksum="4D02117A1F013833" modified="2017-06-07" version="1">MPNVQQELGLSDEQFGKLQLFNRILISYNDFRQVFEVASLMLDGDLYRNYPRENRQLVIALNMAAVIAYSRPFLNSGGELAHNRLPRRVLRDFTAEELNIHEQGLNDRNTTMAHSDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6V9</accession>
    <name>A0A1W1I6V9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48768">
        <property type="protein sequence ID" value="SLM48768"/>
        <property type="gene ID" value="NSJP_2601"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2601"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012777285" description="Endo/exonuclease/phosphatase domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="407" mass="46067" checksum="D7F97E38EC2B405C" modified="2017-06-07" version="1">MTLCRRWVIVVVFGIWTAACSSAPALFDDKAESPLASAPPPATLKFLTFNALHGLATGRVSVSLGETPEQNRRRFQLFIKQLELERPDVVFLQEVNPLPDRAQYYVEALEAVGLHYRVVYQVDACGVRFSGDRALFPDLNNGLAILAKEELELKKIMGLRLSGDLGNCRSNSGFQLGELRYGLIAEIGLPGRKGRFLLASTHLHSGFETGGRFMNLLASLHRDGRLRDYPSFKWAVDQTRLRRIGELNVLIRTLNKLKREEGYEGIVIAGDLNFERDFPEYREVELLRFKDTALLGLEVNELFTADPTVNAWIRQDAEAPVPTLLTNAMASEEMAVRERIIAAYREEMIRPRRIDYIFTDTDFPRYCLRQTLFGLEMDDKGFPASDHYGILNTYSLRTPNQMCPPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I700</accession>
    <name>A0A1W1I700_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48774">
        <property type="protein sequence ID" value="SLM48774"/>
        <property type="gene ID" value="NSJP_2607"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2607"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="118" mass="13109" checksum="9150EE80E191C491" modified="2017-06-07" version="1">MKYLCLVYVEEQTLHAMPRHERIALSDESMAYCGNLQKQGQLLASSPLHPVETATTVRVREGRTSTTDGPFAETKEQLGGFLMIDVRDLNDAIRIAAHFPAARYGSVEVRPMKEDGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I769</accession>
    <name>A0A1W1I769_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Competence protein ComM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">comM</name>
        <name evidence="3" type="ORF">NSJP_2677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2677"/>
    <dbReference type="EnsemblBacteria" id="SLM48844">
        <property type="protein sequence ID" value="SLM48844"/>
        <property type="gene ID" value="NSJP_2677"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2677"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032508">
        <property type="term" value="P:DNA duplex unwinding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="211"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="509" mass="55136" checksum="A6C8E1D930BAA854" modified="2017-06-07" version="1">MLAKVLSVALVGLDAHLIEVEVDIAGGLPQFSVVGLPDATVRESRDRVRSALKNTGFHFPAKKITVNLAPADVKKEGAGLDLAIAIGILVAEELVPADRVLRRVLVGELSLDGHIKPVPGALSIGIACGREYGLLLPARNADEAALVDGVVAYPVHTLPEAVGFLRETQTIEPVVTDRVGFGVVRPAADEDYGDVKGQAHAKRALEIAAAGEHNVLMVGPPGSGKTMLAKRLPTILPLMKPDEAIETTRIHSVAAQLTAGSALLTVRPFRAPHHSISDAGLIGGGTIPRPGEVSLAHNGVLFLDESPEFRRPVLDALRQPLEDGHVTLTRVSGSLRYPARFMLVAAMNPCPCGYYGDRSKECVCTPHQIRRYRARLSGPLQDRIDIHIEVPPVPVREFHDRGAEPESSSAIRTRVLEARDRQSARYRDDGIHTNAQLKPRLVKRYCGLDHSGRELLERAMSKLGLSARAHGRILRVARTIADLAGCERIDPVHVAEAIQYRSLDRRLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I789</accession>
    <name>A0A1W1I789_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48864">
        <property type="protein sequence ID" value="SLM48864"/>
        <property type="gene ID" value="NSJP_2697"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2697"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012235631" evidence="2">
        <location>
            <begin position="19"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="65" mass="7169" checksum="413B0BC123A7B009" modified="2017-06-07" version="1">MKKYMFVLILGLPVSLVAGCTTEKHYPPPAPTIIHEERPSAAESRSDAREAAREGAREGARDAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7D7</accession>
    <name>A0A1W1I7D7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4136 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2765"/>
    <dbReference type="EnsemblBacteria" id="SLM48932">
        <property type="protein sequence ID" value="SLM48932"/>
        <property type="gene ID" value="NSJP_2765"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2765"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025411">
        <property type="entry name" value="DUF4136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13590">
        <property type="entry name" value="DUF4136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4136" evidence="1">
        <location>
            <begin position="25"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="193" mass="21582" checksum="5EC6527EEDB55664" modified="2017-06-07" version="1">MARRNFLHYCLIIWSLSGCASYKVGYDYDRSVDFHSYRTYEWMRDQQEKTGDRRVDSSSTDIRVRTAIAAQLGLKGYAASTAGRPDFLVAYYIQVKEGPADQSQQYFSDGMAGKPFVHSVDTRNPSGKPKAEPEAPSYAAGTLLVDIIDASSKKLAWRGTAAGTVDPSLSSQERDERIRIILRDVLSNFPPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7I1</accession>
    <name>A0A1W1I7I1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48960">
        <property type="protein sequence ID" value="SLM48960"/>
        <property type="gene ID" value="NSJP_2793"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2793"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012099604" evidence="1">
        <location>
            <begin position="24"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="294" mass="32752" checksum="E2FB13ACD8763A7B" modified="2017-06-07" version="1">MTRVFLLALICFVELSVAFSARADAPASGEGSLTAASRPLIVYLDVASSTWRSRGRVSFGIVPTLRMKLVSAGFDVTQDPERPRDLILRIDYREERGRPITIDLAGTEIHCTMVLDQPSKGPVWTIRIHESPSYAELVSAPYVEVVEKFQANPYFYFIGDLIRGWSDFSFDPTEALIQALARQVEQKRNSRGTTELDTLLSPAETFPDLDLHFADTAQENTVEELGRLRDMRALDVLQQLLSDADRRTRLRAVRAIGEFDAPSVEPAVMRVAQADVDAEVREAASAVLAKRVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7L7</accession>
    <name>A0A1W1I7L7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2636"/>
    <dbReference type="EnsemblBacteria" id="SLM48803">
        <property type="protein sequence ID" value="SLM48803"/>
        <property type="gene ID" value="NSJP_2636"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2636"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="137" mass="15770" checksum="A353E0E36F361682" modified="2017-06-07" version="1">MKSYREELWFETKTRREYINITRHVEAVVRKSGVAEGLVLVNAMHITASVYINDDEAGLLQDYDRFLEAVAPQDAAYRHNETGEDNGDAHIKRQLMGREVVVAITGGRLDFGPWEQIFYGEFDGRRRKRVLVKVIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7M3</accession>
    <name>A0A1W1I7M3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Anion-selective porin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2833"/>
    <dbReference type="EnsemblBacteria" id="SLM49000">
        <property type="protein sequence ID" value="SLM49000"/>
        <property type="gene ID" value="NSJP_2833"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2833"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010870">
        <property type="entry name" value="Porin_O/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07396">
        <property type="entry name" value="Porin_O_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="593" mass="66048" checksum="1BDA5FAAA9FE3BA2" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7U6</accession>
    <name>A0A1W1I7U6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48929">
        <property type="protein sequence ID" value="SLM48929"/>
        <property type="gene ID" value="NSJP_2762"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2762"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012506532" evidence="1">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="105" mass="11199" checksum="8C2E3BFEA33DA0E5" modified="2017-06-07" version="1">MPIVYAFLLLLAAVTTVQAQPVSQTTINDVVKGDVLYWEGEELVVREISGHEVRMRVTADTKIEGAAARLKTGDKIAAQLAADGHATTITLQIPDGDASTAPRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I802</accession>
    <name>A0A1W1I802_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49115">
        <property type="protein sequence ID" value="SLM49115"/>
        <property type="gene ID" value="NSJP_2948"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2948"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="215" mass="24012" checksum="757AC59999AE51DE" modified="2017-06-07" version="1">MDDHADYRAALLSAILPGGGHVFRQRIGAGLVSFSVTVLLIGISLALGRVSGRAAEVFFFMLLALPWWAFQSYDAFLGPSLHSSNWLRTWRQVWARGHDIRLLGLLLVISAVNDTWIILKNLDYLLPFYCTKLDGLPGFLTKAISPALHLGVGVGFMKLARWSLFLYLIYAAYGFTNGLVNLTCFGPGRIRNTLLVAIVVSTVYVVWRRRILLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I803</accession>
    <name>A0A1W1I803_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">dnaJ</name>
        <name evidence="10" type="ORF">NSJP_2967</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2967"/>
    <dbReference type="EnsemblBacteria" id="SLM49134">
        <property type="protein sequence ID" value="SLM49134"/>
        <property type="gene ID" value="NSJP_2967"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2967"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
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        <location>
            <begin position="144"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="144"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM49134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="381" mass="42020" checksum="CBC800B67183E3D6" modified="2017-06-07" version="1">MILRGHCLSVAKRDFYETLGVERTASDDEVKKAYRKLARQFHPDLQTGDQQKKHAEEKFKEINEAYEHLSDQEKRKRYDMFGHAGAQGGAGFEGFDFGRGGGFGDVFNDIFEDFFGGQRGGTRPERGNDLQYNLELTFEEAVYGKDAKLKIPRWESCTDCKGSGAKSTSSIKTCPSCKGAGQIRLQQGFFSVSRPCGQCDGAGRIVTEPCPACQGRQRIYRERTIAVHIPAGIETGMRLRLANEGEHGVNTGPPGDLYVAITVKSHPVFVRKGNDILCDVPINFVTAILGGKIEVPTLKGTTVLKVPTGSQPDKVLRLKGLGVPSLKGQVTGDQLFTLKVQVPTKLTGRQKELLMEFAKESGMSMEEDGDGFFDKMKTFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I829</accession>
    <name>A0A1W1I829_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arylsulfatase A-related enzyme</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3015</name>
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        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49182">
        <property type="protein sequence ID" value="SLM49182"/>
        <property type="gene ID" value="NSJP_3015"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3015"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012596663" evidence="4">
        <location>
            <begin position="23"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="60"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="797" mass="87578" checksum="5B09A8DD2ACD3041" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I833</accession>
    <name>A0A1W1I833_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2914</name>
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    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49081">
        <property type="protein sequence ID" value="SLM49081"/>
        <property type="gene ID" value="NSJP_2914"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2914"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013297644" evidence="1">
        <location>
            <begin position="31"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="167" mass="18817" checksum="845F77450CC4F613" modified="2017-06-07" version="1">MTGVSRAAAITLAVVTAAACYLAVPANGWAEDQEMSPSDYELLRSDIRTKKATLIAQQMKFSDQEAAVFWPVYRQYEVELAGILDKKIALLKDYLSHHETMTDAQAKQLAESVFQVDQQTLDLRVKCFGTLQKSLPAKTVVRWLQIERRLQLYVDAQLAKELPAIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I836</accession>
    <name>A0A1W1I836_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_2852</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49019">
        <property type="protein sequence ID" value="SLM49019"/>
        <property type="gene ID" value="NSJP_2852"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2852"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_sugar_transpr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012664278" evidence="7">
        <location>
            <begin position="25"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="132" mass="14375" checksum="5DC8831EBC0E39E9" modified="2017-06-07" version="1">MNVSNLFSVLLATAYVFSASTGLAGEDLEAEVEALATSAITMKEVIGFVAGFGTTFAAVPDLVVMFKRRSTVGMNPTMAAIMGTFQFVWVYYGFLIASRPVIIWNVVAVVINFIMVGAYYHFLRGERAQAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8C2</accession>
    <name>A0A1W1I8C2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3100"/>
    <dbReference type="EnsemblBacteria" id="SLM49267">
        <property type="protein sequence ID" value="SLM49267"/>
        <property type="gene ID" value="NSJP_3100"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3100"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010038">
        <property type="entry name" value="MoaD_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01687">
        <property type="entry name" value="moaD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="90" mass="9861" checksum="91A1D152EF92488D" modified="2017-06-07" version="1">MIKVRIPTPLRPLTKGKSEVEAQAADIAAMIDTLNQAHPGLKDRLCDETGELRRFVNIYVNEEDIRFLKGKETSLNDGDEVSIVPAIAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8L0</accession>
    <name>A0A1W1I8L0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49344">
        <property type="protein sequence ID" value="SLM49344"/>
        <property type="gene ID" value="NSJP_3177"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3177"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="87" mass="10133" checksum="DB06EA2B6AD03A94" modified="2017-06-07" version="1">MPWYRLSFQLPVVDDLASIEMPVAQRLFEKTKWIASNVDNLRHEPAAQDLPDLCKYAVGEWRIFYALDRAEQLVDIHAIIHRSSLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8L2</accession>
    <name>A0A1W1I8L2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49261">
        <property type="protein sequence ID" value="SLM49261"/>
        <property type="gene ID" value="NSJP_3094"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3094"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="64" mass="7304" checksum="13B1844EF0407E03" modified="2017-06-07" version="1">MVLIYENDPLDNEHARGRFYHVCRGRVDRTELSIPPVDQPHECPSCGIDLEAEDFFVAMQKGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8M8</accession>
    <name>A0A1W1I8M8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mutator MutT protein</fullName>
            <ecNumber evidence="5">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mutT</name>
        <name evidence="5" type="ORF">NSJP_3183</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3183"/>
    <dbReference type="EnsemblBacteria" id="SLM49350">
        <property type="protein sequence ID" value="SLM49350"/>
        <property type="gene ID" value="NSJP_3183"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3183"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008413">
        <property type="term" value="F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003561">
        <property type="entry name" value="Mutator_MutT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00586">
        <property type="entry name" value="mutt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="8-oxo-dGTP binding" evidence="2">
        <location>
            <begin position="33"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>8-oxo-dGTP</name>
            <dbReference type="ChEBI" id="CHEBI:77896"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>8-oxo-dGTP</name>
            <dbReference type="ChEBI" id="CHEBI:77896"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR603561-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR603561-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="134" mass="15463" checksum="A39735DF06A5A01E" modified="2017-06-07" version="1">MKLVEVAAGLIYEDGRYLIAKRKAGVHLGGLWEFPGGKREEGETLEDCLRRELLEELDIRIDIPIPFRIIRHDYPEKTVELHFFRCAIETGRPSPVDCAELRWVLPSELSEYEFPPADRPIIDALQYQTAGQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8U8</accession>
    <name>A0A1W1I8U8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49442">
        <property type="protein sequence ID" value="SLM49442"/>
        <property type="gene ID" value="NSJP_3275"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3275"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012235637" evidence="2">
        <location>
            <begin position="27"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="141" mass="14945" checksum="9A0A41EAC42687B7" modified="2017-06-07" version="1">MNMTKSGLPVFLFVGASFVFGASAFAGEPAGIGEKGTGQTQKSTDRQQSGSKPDMSQVPEEIQEGKSAQAAQELNQQQQGIRGSAQEPAGIGEKGTGQTKKSTERQQSGKQPDMSQVPEELREGKSARAAGEMEQQDKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I901</accession>
    <name>A0A1W1I901_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Vitamin B12-dependent ribonucleotide reductase</fullName>
            <ecNumber evidence="4 10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">nrdJ</name>
        <name evidence="14" type="ORF">NSJP_3192</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3192"/>
    <dbReference type="EnsemblBacteria" id="SLM49359">
        <property type="protein sequence ID" value="SLM49359"/>
        <property type="gene ID" value="NSJP_3192"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3192"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02888">
        <property type="entry name" value="RNR_II_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013678">
        <property type="entry name" value="RNR_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013344">
        <property type="entry name" value="RNR_NrdJ/NrdZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08471">
        <property type="entry name" value="Ribonuc_red_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02504">
        <property type="entry name" value="NrdJ_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="8 10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuc_red_2_N" evidence="13">
        <location>
            <begin position="31"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="12">
        <location>
            <begin position="182"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="12">
        <location>
            <begin position="790"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1068"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1091"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM49359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1181" mass="131256" checksum="4B69CC03ACB0D266" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I905</accession>
    <name>A0A1W1I905_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">THAP4_heme-bd domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3308"/>
    <dbReference type="EnsemblBacteria" id="SLM49475">
        <property type="protein sequence ID" value="SLM49475"/>
        <property type="gene ID" value="NSJP_3308"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3308"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP4_heme-bd" evidence="1">
        <location>
            <begin position="8"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="187" mass="21469" checksum="126DB8419A6D0F7F" modified="2017-06-07" version="1">MQSDLSKLGPLAPLAGIWEGEKGEDVAPSDDRGTEHNKFHERMTFEPIIPVQNHEQMLYGLRYATVARRIGETYPFHEEVGYWLWDPVERQVLRCFIIPRGIALIAGGAAEPTSMEFTLVADVGSETYGICSNRFLDREFKTVRFELTVTIFGRDRFHYKEDSLLRMPGKPDLFHHTDQNILRRVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I958</accession>
    <name>A0A1W1I958_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type III restriction protein res subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3252"/>
    <dbReference type="EnsemblBacteria" id="SLM49419">
        <property type="protein sequence ID" value="SLM49419"/>
        <property type="gene ID" value="NSJP_3252"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3252"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029464">
        <property type="entry name" value="HSDR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13588">
        <property type="entry name" value="HSDR_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="200"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="843" mass="96330" checksum="AAB953C56A4E9907" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9K3</accession>
    <name>A0A1W1I9K3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein PilH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pilH</name>
        <name evidence="3" type="ORF">NSJP_3527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3527"/>
    <dbReference type="EnsemblBacteria" id="SLM49694">
        <property type="protein sequence ID" value="SLM49694"/>
        <property type="gene ID" value="NSJP_3527"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3527"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="120" mass="13343" checksum="BF7866FEC172995E" modified="2017-06-07" version="1">MSKIVVVDDSYAELQVIEGYLKGANHTVVSYPNSEKLEEKILNEKPDLIVMDVVMPGRNGFQACRDLKNDDRTKNIPIILCTSKGNESDKFWGQQQGANAHVVKPFKGEELLAAVKRVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9K4</accession>
    <name>A0A1W1I9K4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aatB</name>
        <name evidence="4" type="ORF">NSJP_3382</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3382"/>
    <dbReference type="EnsemblBacteria" id="SLM49549">
        <property type="protein sequence ID" value="SLM49549"/>
        <property type="gene ID" value="NSJP_3382"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3382"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012641934" description="Aminotransferase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="31"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="397" mass="42294" checksum="5A511A38651CC658" modified="2017-06-07" version="1">MKLASRVGRIAPSPTLAMAATAKAMAAQGIDVVDFSTGEPDFDTPDSVKAAAEAAIRAGFTKYTPSSGTEELRGAVVDKLQHELGLRYEKSQVLISCGAKHSLYNVAEALLEAGDEIIIPTPYWVSYSDQALLNDATAVLLPTKEEEGYAIDAEELERLITPRTKAILVNSPCNPTGATYGRATLEAIAAIALRHDLLVISDEIYEKIVYDGTVHVSIATLGADIAARTVIINGVSKAYAMTGWRIGYAAGPRELIAAMGNVQSQSTSNPCSISQKAAVAALRDGGAFTERMVVEFDRRRRVIVEGLNAIRGVSCRMPTGAFYAFPNVSGVLGRRGPDGVVKTPTDLANYLLNTAHIAVVPGEPFGSQAHVRLSYATGMETITRGLERLDKALARLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9L8</accession>
    <name>A0A1W1I9L8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Peptidoglycan-associated lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3326"/>
    <dbReference type="EnsemblBacteria" id="SLM49493">
        <property type="protein sequence ID" value="SLM49493"/>
        <property type="gene ID" value="NSJP_3326"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3326"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="3">
        <location>
            <begin position="75"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="189" mass="20662" checksum="EF4102DB4D3B812D" modified="2017-06-07" version="1">MKKSTEIALMGLLVVSALGLPACSSLYGSGTGDEQVSRNERIDEPVIKHIAPPDPSLASRRSGPTMRAELAARNDTGMPKGSLADVLFDFDRYTIRAEAVPALEANAKRLRRQGVTGVLLEGRGDEVGTAAYNMVLGDLRARNVKQYLEDLGLDVEVDTTSYGKDRPLCFRHDDDCMQVNRSVHFVVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9X0</accession>
    <name>A0A1W1I9X0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3647"/>
    <dbReference type="EnsemblBacteria" id="SLM49814">
        <property type="protein sequence ID" value="SLM49814"/>
        <property type="gene ID" value="NSJP_3647"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3647"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="2">
        <location>
            <begin position="2"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="224" mass="24235" checksum="CC079E71671DE79C" modified="2017-06-07" version="1">MRKVVVGAMVSMDGVMQAPGGPEEDPTGGFTFGGWTAVLGDDPVFGEALGKLFDEPFDLLLGRRTYEIFAAYWPYAEGGPSDDIARIFNRVTKYVATRKGMDLTWNGSRTLRDAVKDVAKLKQEDGPTLLTQGSTELVHALLSAGLVDEICTFTFPLLLGKGKRLFNADSQPRTFKLTHSAVSPNGLVAATYVRGGEVKTGTVGGPVEPSTAELARRERLRHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA15</accession>
    <name>A0A1W1IA15_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49832">
        <property type="protein sequence ID" value="SLM49832"/>
        <property type="gene ID" value="NSJP_3665"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3665"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="72" mass="7797" checksum="A716522F650431E9" modified="2017-06-07" version="1">MLMQKVEMTNLRENSGVTVMMNKGMKHDLVHTILEAALAVGAGMSWWMVGNLILGDVIGLAVDMVRGGRLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA85</accession>
    <name>A0A1W1IA85_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Phenylalanine racemase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="7">5.1.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3767</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.1.11" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3767"/>
    <dbReference type="EnsemblBacteria" id="SLM49934">
        <property type="protein sequence ID" value="SLM49934"/>
        <property type="gene ID" value="NSJP_3767"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3767"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047462">
        <property type="term" value="F:phenylalanine racemase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="745"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1433"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2946"/>
            <end position="3023"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="779"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1470"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="4422" mass="482604" checksum="17EA9E9ADE1EC004" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAB0</accession>
    <name>A0A1W1IAB0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3763"/>
    <dbReference type="EnsemblBacteria" id="SLM49930">
        <property type="protein sequence ID" value="SLM49930"/>
        <property type="gene ID" value="NSJP_3763"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3763"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="79" mass="8959" checksum="DE872A30B8216419" modified="2017-06-07" version="1">MLRFDQPDGLYHLISLCSACQPDRLAKRFNRMTFVVSTKQSGQNPHCVKVTDVFKTDSDRASLKRPIVGRPIAQIRADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAC8</accession>
    <name>A0A1W1IAC8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polysaccharide biosynthesis protein CapD (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3783</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3783"/>
    <dbReference type="EnsemblBacteria" id="SLM49950">
        <property type="protein sequence ID" value="SLM49950"/>
        <property type="gene ID" value="NSJP_3783"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3783"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="4">
        <location>
            <begin position="4"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_2" evidence="5">
        <location>
            <begin position="505"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="868" mass="96799" checksum="AD90334D53EC4239" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAG5</accession>
    <name>A0A1W1IAG5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3818"/>
    <dbReference type="EnsemblBacteria" id="SLM49985">
        <property type="protein sequence ID" value="SLM49985"/>
        <property type="gene ID" value="NSJP_3818"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3818"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="260" mass="30070" checksum="1DC87F002BBF32F3" modified="2017-06-07" version="1">MKVVLFCGGLGLRIREYSQNIPKPMVPIGYRPVAWHIMKYYAHYGHKEFILCLGHAADVVKQYFLNYSECASNDFVMSEGGKKVDLINTDIQDWRITFVETGANANIGQRLKAIEKYLGDDEEFLANYSDGLTDLPLPVQLAHFRKMNKVASFASITPRLSYHLVSADADGVVETIQEMNKTSLRINGGYFIFKRRIFDYLLPGEELVQEPFRRLIKDRQLIGYRYDGFWAAMDTFKDKQVLDEIYAQGRAPWEVWRKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAQ7</accession>
    <name>A0A1W1IAQ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50137">
        <property type="protein sequence ID" value="SLM50137"/>
        <property type="gene ID" value="NSJP_3970"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3970"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="216" mass="23521" checksum="2187544C5270B377" modified="2017-06-07" version="1">MIFMRRQVPLLITMIAGLVFAAQYYIPHPQSEYMLTSVTKWLQIIGGFALILGISSLFQQHAVKIRRKESGWGYSLVLYAGIVGTIAAGLLANGKESVDGSMTAFGWVYSFMMVPLQGTMFAILAFFIASAAYRSFRARSREAAVLLVAAVIVMMGRVPLGEYILPISGDVSQWILNVLNASVRRAILIGVSLGAVALSFKIIFGVERSYLGGGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAX4</accession>
    <name>A0A1W1IAX4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 4</fullName>
            <shortName evidence="5">EF-4</shortName>
            <ecNumber evidence="5">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">lepA</name>
        <name evidence="7" type="ORF">NSJP_3983</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3983"/>
    <dbReference type="EnsemblBacteria" id="SLM50150">
        <property type="protein sequence ID" value="SLM50150"/>
        <property type="gene ID" value="NSJP_3983"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3983"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="50"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="62"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="179"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM50150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="646" mass="72019" checksum="1A96DA8BE47D7018" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB28</accession>
    <name>A0A1W1IB28_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycos_transf_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3806"/>
    <dbReference type="EnsemblBacteria" id="SLM49973">
        <property type="protein sequence ID" value="SLM49973"/>
        <property type="gene ID" value="NSJP_3806"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3806"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="181"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="363" mass="40214" checksum="EF25D15F49092682" modified="2017-06-07" version="1">MKIAFVNDGIHEYASGDPSAVGGAERQQWLLARALAAAGWSVKVGTRHRLERGRRETIDGVDYVGIGIGPYLPALFRFLRSERPNWFYLRCAQPLLGPMVQLARVSNVRTIFSAGFDTDIQPREALTRRRRLWPLYAWGLAQVEKLFLQHGRQLSGLPTKWRSKAYIVRSIAGARAPVKPHAMREKYVAWIGMLRRHKRPDLLIEIARKAPALRFVLCGGQSTFGTTAGYSEQIMNRLRDLTNVNYCGQVSPEHAEGIIRNAAVLLSTSSSEGFPNTFLQAWSSGTPVVSLEIDPDDIIKRYGLGAMSNGVVGAVRDITRLIASADQRDDIAVHTQRYVTQYHSDAAVVEAFEAAVSGASLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB72</accession>
    <name>A0A1W1IB72_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Signal peptidase I</fullName>
            <ecNumber evidence="3 6">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">lepB</name>
        <name evidence="10" type="ORF">NSJP_3982</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3982"/>
    <dbReference type="EnsemblBacteria" id="SLM50149">
        <property type="protein sequence ID" value="SLM50149"/>
        <property type="gene ID" value="NSJP_3982"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3982"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="9">
        <location>
            <begin position="46"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM50149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="258" mass="29066" checksum="24F52113FBFB925B" modified="2017-06-07" version="1">MSVEPNSSGPEDLVSPVRETTQDVPGPTSLAEAAAMAQPARKSVFREYAEAIVVAMLLAFAIRVFVVQAFKIPSGSMIPTLLIGDHILVSKLSYGIQWPSQCKFQWGFPPVNCYASHAIVEFGKPQRGDIVVFRFPEDEEKDFIKRIVGTPGDQIQVKNKVVLVNGVPLDDKTFTQRIDPGIIDGTINPRDNFGPVTVPEGSYFVMGDNRDQSLDSRFWGYVREEKIRGKAFRIYWSWSGHGQWTEWVRWERFAKAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB97</accession>
    <name>A0A1W1IB97_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="5">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NSJP_3876</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Fe(III)-[cytochrome c] + H2O + nitric oxide = Fe(II)-[cytochrome c] + 2 H(+) + nitrite</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3876"/>
    <dbReference type="EnsemblBacteria" id="SLM50043">
        <property type="protein sequence ID" value="SLM50043"/>
        <property type="gene ID" value="NSJP_3876"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3876"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012076997" description="Copper-containing nitrite reductase" evidence="8">
        <location>
            <begin position="33"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="52"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM50043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="328" mass="35399" checksum="F5E1D78D4C35D33C" modified="2017-06-07" version="1">METRRPHPHPILAGLAACLLIPLSLDATPANAKTHEVAMTAVETDVVIDGSGEKYAAWTFNGTMPGPVIRVTEGDTIKFTLTNPATNKYPHAMDFHAAEIDFLKNYRAINAGETLTYSFVAKKPGVFFYHCGAPPMIQHVARGMFGAVIVDPKNAKAWPKADREYVLVQSELYKNPDDVQAMFDRKFEHVIFNGGVFKYHPFVTGGGKLDAKPGERVRIFFVNAGPNEFSAFHPIGEIWDSVYESGNPANKLSGVQTYVVGPGGAAVFDVVVESAGAYPLVTHSLTGALRGGIAVLVASPDAGSQPLMPMVPWKVLVPQTEITPVPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBA1</accession>
    <name>A0A1W1IBA1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Glycosyl transferase, group 1</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_4024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4024"/>
    <dbReference type="EnsemblBacteria" id="SLM50191">
        <property type="protein sequence ID" value="SLM50191"/>
        <property type="gene ID" value="NSJP_4024"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4024"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="18"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="186"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="377" mass="42103" checksum="4658D6BA05A2987A" modified="2017-06-07" version="1">MKGCARICHVAVADLWAGAEVQLKVLLSQLARMQGFEHTVILFNEGRLEQEIRRLGVDVKVFPEQRWSGSKLFRELMKEFKAGQYKIVHTHKYKDTILAAPASRMAGIPYVVRTVHGLREPFHGLQSLKMNIYECIERRVHQHCVDAIIAVSPQIEDRLKCECGVERVVCVKNGLDLETFPSPIHRDRKRAELGIDTNTCLIGAVGRLTPVKGLEYLLRAARILVSRQCRVQIAIVGDGSLREALEQQARDLGIVENIVFLGHREDTQELMFALDIFALPSLSEGIPMALLEAMAAGRAIVASRVGGIPEVIRDGVEGYLVEPKDVQGFADRCLQLIESSDLASRLSLSARRRVEQNFSAQGMARQVTSLYDELIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBF3</accession>
    <name>A0A1W1IBF3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_4153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4153"/>
    <dbReference type="EnsemblBacteria" id="SLM50320">
        <property type="protein sequence ID" value="SLM50320"/>
        <property type="gene ID" value="NSJP_4153"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4153"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="370"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="614" mass="69819" checksum="45A90C8E008E055B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBL1</accession>
    <name>A0A1W1IBL1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 5">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rmlB</name>
        <name evidence="7" type="ORF">NSJP_4124</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4124"/>
    <dbReference type="EnsemblBacteria" id="SLM50291">
        <property type="protein sequence ID" value="SLM50291"/>
        <property type="gene ID" value="NSJP_4124"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4124"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="4"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM50291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="338" mass="37716" checksum="89EAC8EC1C297C14" modified="2017-06-07" version="1">MKILVTGGAGFIGSHLVRRLVTGGGHEVVNLDALKYSGNPANLRDLEGDRRYRFVHGDIGDQPLVERVLREHRIEAVVNAAAETHVDRSIMDPGTFARTDVVGTGVLLEESRRAGVSRFLQVSTDEVYGSVETGSSTEEAPLVPRSPYSASKAGGELLVLSYWTTFGFPVMVTRGSNTYGPNQYPEKFIPLFVTNAIDDQALPLYGDGRQCRDWLAVEDHCAAIDHVLLRGEPGQVYNIGGGNERENLVVAERLLACLGKPAQLIRFVRDRPGHDRRYAVDCTKLHALGWRPSVSFEGGLNATVEWYRTHESWWRPIKSGEFRRYYEEQYRTRLNEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZL3</accession>
    <name>A0A1W1HZL3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF374 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0013"/>
    <dbReference type="EnsemblBacteria" id="SLM46185">
        <property type="protein sequence ID" value="SLM46185"/>
        <property type="gene ID" value="NSJP_0013"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0013"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd07983">
        <property type="entry name" value="LPLAT_DUF374-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007172">
        <property type="entry name" value="DUF374"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04028">
        <property type="entry name" value="DUF374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF374" evidence="1">
        <location>
            <begin position="68"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="210" mass="23026" checksum="985A8101A8B45E7E" modified="2017-06-07" version="1">MSGTAGKRLERWVKLSVLPPVGAWIIRCLGRSMRIESKGHEVADDLYREGKRAIFVFWHARQLLMPFAYRGERAYVLISQHQDGEIIARIVERFGFLAVRGSSTRGGVEALRELIRLGHSGLDLVVTPDGPKGPARVAKIGVIQLARATGLPIVPIAAACSKKNSSRAGIGSWCHGPARAGCFFGAARSSFRVRPAPKSLKRSGWSWKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZP1</accession>
    <name>A0A1W1HZP1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipid-A-disaccharide synthase</fullName>
            <ecNumber evidence="2">2.4.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">lpxB</name>
        <name evidence="10" type="ORF">NSJP_0015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:67828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="ChEBI" id="CHEBI:176338"/>
            <dbReference type="ChEBI" id="CHEBI:176343"/>
            <dbReference type="EC" id="2.4.1.182"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.182" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0015"/>
    <dbReference type="EnsemblBacteria" id="SLM46187">
        <property type="protein sequence ID" value="SLM46187"/>
        <property type="gene ID" value="NSJP_0015"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0015"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008915">
        <property type="term" value="F:lipid-A-disaccharide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003835">
        <property type="entry name" value="Glyco_trans_19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30372">
        <property type="entry name" value="PTHR30372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02684">
        <property type="entry name" value="LpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00215">
        <property type="entry name" value="lpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM46187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="397" mass="43381" checksum="98FB53B18D701157" modified="2017-06-07" version="1">MGPPIEPACQAGRSVPDGGRRMPRILIVTGEASGDLHGANLAREILSLDPSAQLVGIGGNGMKAAGVALIPGVPQLDLVGLIGLSAVRALVQRIRAIRRVLRSEPWDLVVLIDNPALNLHFARVARAAKQKVLYYIAPQIWAWRPRRIKWIQRRVNHVVVILPFEQEIYRRAGVPCTYVGHPLLDAVAPRYDRPALRRRFGLDPEAPVVGLLPGSRVAEVELLMPVLLKAAADFLARYPKTQFILAQAPSIKDALIREQLHGSPVPVVLVRDQASEVMAASDILWIASGTATLQAAVVGTPMVLLYKTTLPTYVVARCLIKVKWIGLVNLIAGSSVVPELIQGDATAERLIAQTERLLNDRRAYDDMKDNLQQVRLTLGEPGASRRAAQVVLDECRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZR3</accession>
    <name>A0A1W1HZR3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0074"/>
    <dbReference type="EnsemblBacteria" id="SLM46246">
        <property type="protein sequence ID" value="SLM46246"/>
        <property type="gene ID" value="NSJP_0074"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0074"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012574123" evidence="3">
        <location>
            <begin position="31"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="519" mass="57177" checksum="286778E2E5D8CD26" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZV0</accession>
    <name>A0A1W1HZV0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0080"/>
    <dbReference type="EnsemblBacteria" id="SLM46252">
        <property type="protein sequence ID" value="SLM46252"/>
        <property type="gene ID" value="NSJP_0080"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0080"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005534">
        <property type="entry name" value="Curli_assmbl/transp-comp_CsgG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03783">
        <property type="entry name" value="CsgG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ_6" evidence="2">
        <location>
            <begin position="365"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="433" mass="47779" checksum="E372F2B7DC84C9C6" modified="2017-06-07" version="1">MTVRSSHCGEPYLDGTLPPMRRSVAAQRSRIFLNMILAVGIGAGASGCGVAYTIVKSESKLDRLAVPMTKAQIIEEIGRPDRVLRDDGRLLVWEYSLTARKQWLYELALCPISVWIGGCLFYPFTNIAADQQREYPHHVVMVNEELCAWGPPAAILQRRKACVATGVQAVQAVNGRFEPVVTGNGPIDRENIDRYRTMAVMLFEDAAGARGSGSRVTGIVTTLMLDLDIHMVERAKLDEVLKEQVIQLTHADDANVLKVGRLVGAQAIIVGEVQQWERRPQDRMHSVSLALRMIDVETGLLLFNGEGHLTDPTTDDPEGSARLIVHRILTRFGAQTGLLGSGRIGVNWELLEERGTRFYLVRELRTGLPGEKAGLKVGDRIVACNGASLATARNERDAKRLCHVDAGEILELEVRRTDEPLHLMVTADKRPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZY5</accession>
    <name>A0A1W1HZY5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0027"/>
    <dbReference type="EnsemblBacteria" id="SLM46199">
        <property type="protein sequence ID" value="SLM46199"/>
        <property type="gene ID" value="NSJP_0027"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0027"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="72"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="475" mass="55001" checksum="30246C45E61F376C" modified="2017-06-07" version="1">MTPPDSPRQSNAPYDGSALIADPIHKYVSFTVPYAQSDQHEGTEKDLIDSPWVQRLRYIYQLQSARWVYPSAEHTRFVHSLGTMHVAGKFARHLYPFLKKVAPDAPSEHYVESFLRVTALAHDIGHGPFCHFFDDNFLHSFNASHERLGQIIIRDHLGPIIRKIRRSPSGSFEKGEELDPDQIAHVILKEKGKDNSRLPRWLNVLQPVIGGSYTADNLDYVLRDSYMCGVAVGPVDLTRLIHYTILTDKGFTIHKTGLPALQMFLNTRMYLYSNVYFHRTTRAIDIHLRDIFGDTMKLIFPHDPRKKMDDYLTLTDWSLLEQARSWRKSRQSEERRLGEEWARILDRNVKWKMAYSTVLKEKGQERGMDFPSDEHFARQIRKELPAPLQKIEFRVDMAPLDPRPDPKDRRGNPLYVYDPGTKQVSVEPLEEFLDLLPTRLVQFRIYSHDHEHDAALSRAAATVLNKTPSSLESNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZY7</accession>
    <name>A0A1W1HZY7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0144"/>
    <dbReference type="EnsemblBacteria" id="SLM46316">
        <property type="protein sequence ID" value="SLM46316"/>
        <property type="gene ID" value="NSJP_0144"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0144"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="264" mass="28404" checksum="1FB049AE84D8317E" modified="2017-06-07" version="1">MKSALSVVFGVAAVAFIATPVISFAGGTISGKVTYGGKSEQKEFLFSKFPNPKFCPKNPNKSLMDGDKRFLKTVEVGKDGGLKGAVVAVTDIEDKAFVDGYAGTEVTAAFCEFLPFSGVVVNTRPFKVENTDSDPDDPKSTAGVLHNPHSFTVKGSTSATGFNIGLAKKGDKLDKPVTFRGGAEKEGYYRLQCDQHEFMQSFFLPVTNPHFVVVKEDGSFELKDVPAGKHKVVAWHPFAAKGKKVEFEVEVPEGGTANLKAEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I007</accession>
    <name>A0A1W1I007_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46340">
        <property type="protein sequence ID" value="SLM46340"/>
        <property type="gene ID" value="NSJP_0168"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0168"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="83" mass="9428" checksum="B16074B51955478B" modified="2017-06-07" version="1">MHGESDISAVRPRPELDIQGNHLLEEIPMTNDELTKEEFRSLLESLPIIGNETADARLSKLSRHNEALCRKIEQLQRAQLIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I033</accession>
    <name>A0A1W1I033_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TolB protein, periplasmic protein involved in the tonb-independent uptake of group A colicins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TolB family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0184"/>
    <dbReference type="EnsemblBacteria" id="SLM46356">
        <property type="protein sequence ID" value="SLM46356"/>
        <property type="gene ID" value="NSJP_0184"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0184"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014167">
        <property type="entry name" value="Tol-Pal_TolB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02800">
        <property type="entry name" value="propeller_TolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0574">Periplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="447" mass="48487" checksum="E4379F3B9CC0612B" modified="2017-06-07" version="1">MIVMKLAGATLAVLILAAGAVGILESGAADVFLEATRPDFQKISLGILGIHNGGGPEWLGGRLEEVLKKDVKRSLIFELVDLPSLGIKARDVGNGTGSASAAVFKQAAENGVSVLVWGKAAQKDGEKDADVNMEGFVYDSGSDEVVGGKRYAGSPSVVRLMAHRFADELVFRYTGEPGIARTKIAYVSAQGAARELYVMDYDGYDARQLTADGFLNLMPRWSPDRRFLVFTAYRDRNTQDIDMIELATGKRWTIFSQGGLNITPALSPDGNFLAFASSHEGNSEIYRLDTRTKINQRLTVNPSGDLSPSWSPTGRELAFVSDRGGGPQVFLMSADGSNVRRLTFEGDYNAAPAWSPRGNWIAYVCRTPRKEYKLCVITPDGQKRMQLTTGPGVDDSPSWSPDGRHLVFSSSADGKSHIYMIDSDGKNLERLTFEGTHNSAPSWSPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I072</accession>
    <name>A0A1W1I072_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PepSY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0226"/>
    <dbReference type="EnsemblBacteria" id="SLM46398">
        <property type="protein sequence ID" value="SLM46398"/>
        <property type="gene ID" value="NSJP_0226"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0226"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepSY" evidence="1">
        <location>
            <begin position="35"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="103" mass="10918" checksum="CE565BCBB5C62224" modified="2017-06-07" version="1">MRHHLLTAIFVIGMIVGLGTPAWSGKHADLLKDAKVTIDQAIKTALEKVPGTAVEAELEKKHGKAVWEVEIVGADGKVSEVHIDAATGEVIDVETKKGGKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I088</accession>
    <name>A0A1W1I088_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)H:quinone oxidoreductase WrbA</fullName>
            <ecNumber evidence="3">1.6.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">wrbA</name>
        <name evidence="3" type="ORF">NSJP_0091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0091"/>
    <dbReference type="EnsemblBacteria" id="SLM46263">
        <property type="protein sequence ID" value="SLM46263"/>
        <property type="gene ID" value="NSJP_0091"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0091"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012461431" evidence="1">
        <location>
            <begin position="24"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="34"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="201" mass="21159" checksum="F3DB407280675966" modified="2017-06-07" version="1">MKFLPVLLALFFGVCSFPSVSLRAEEASTPSVKVLVTYHSLSGHTERMAEAVASGAKELPGTQVLLKRVGEVTAEDLFSSDAVVVGSPVYWSNMSGEVKSFFDDWQFKFGVFPEFKMKNKVGAAFATGGQVSGGKEVTMLTILAAMLGNQMIVVSGGGAFGASATTEGDSPGIDKGELADARLLGMRVAEISAMLKHGQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0J6</accession>
    <name>A0A1W1I0J6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Twin-arginine translocation pathway signal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0330"/>
    <dbReference type="EnsemblBacteria" id="SLM46502">
        <property type="protein sequence ID" value="SLM46502"/>
        <property type="gene ID" value="NSJP_0330"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0330"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="641" mass="70880" checksum="B818D3CCC9FD4F36" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0N5</accession>
    <name>A0A1W1I0N5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46542">
        <property type="protein sequence ID" value="SLM46542"/>
        <property type="gene ID" value="NSJP_0370"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0370"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="70" mass="8074" checksum="01BEDF1BBE903D29" modified="2017-06-07" version="1">MRTIWFMRDVYLKRGDFLSFGYLLSSYGFGIPLGGHSKCLTGLFRCHWNEPSLGICPFNRIIFPVISVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Q0</accession>
    <name>A0A1W1I0Q0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2Fe-2S ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fdx</name>
        <name evidence="3" type="ORF">NSJP_0408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0408"/>
    <dbReference type="EnsemblBacteria" id="SLM46580">
        <property type="protein sequence ID" value="SLM46580"/>
        <property type="gene ID" value="NSJP_0408"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0408"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="115" mass="12518" checksum="4109B37348560AD0" modified="2017-06-07" version="1">MPHVTFLHPKGRSGSVPRNTTLLDAAKELGFPLNHDCGGNASCTTCRVEVQSGGEHLSEIDFEEQDLLDREALSEPWHRLGCQAKILGDVVVRVPESKWAAPSTGQSEARGVDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I126</accession>
    <name>A0A1W1I126_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC-type transport system, ATPase and permease component</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_0525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0525"/>
    <dbReference type="EnsemblBacteria" id="SLM46697">
        <property type="protein sequence ID" value="SLM46697"/>
        <property type="gene ID" value="NSJP_0525"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0525"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="31"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="554" mass="61627" checksum="2CD697B64B07CC5B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I138</accession>
    <name>A0A1W1I138_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.8.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_0535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.-" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0535"/>
    <dbReference type="EnsemblBacteria" id="SLM46707">
        <property type="protein sequence ID" value="SLM46707"/>
        <property type="gene ID" value="NSJP_0535"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0535"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="51"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="161"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="288"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="648" mass="72361" checksum="03F75ABBC3AACCB9" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1C3</accession>
    <name>A0A1W1I1C3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46784">
        <property type="protein sequence ID" value="SLM46784"/>
        <property type="gene ID" value="NSJP_0612"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0612"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="62" mass="7139" checksum="A3FCDC9AD5AA96CB" modified="2017-06-07" version="1">MAPKTNPDKPAHLNVRDIPRETLFRLKMAAAAEQKTVKDLVLELVHEKIQELERKGLLPRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1E3</accession>
    <name>A0A1W1I1E3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0632"/>
    <dbReference type="EnsemblBacteria" id="SLM46804">
        <property type="protein sequence ID" value="SLM46804"/>
        <property type="gene ID" value="NSJP_0632"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0632"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="91" mass="10269" checksum="4F83D1F9E2DA438B" modified="2017-06-07" version="1">MSGERVGLALDRVWDGGAGPRSITVDHRTEFQSRALEDWAYRRGVQLHFIRPGKPVENAFIESFNGRLRDECLNVHQFASLAEAPGYVRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1E8</accession>
    <name>A0A1W1I1E8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Animal heme peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0653"/>
    <dbReference type="EnsemblBacteria" id="SLM46825">
        <property type="protein sequence ID" value="SLM46825"/>
        <property type="gene ID" value="NSJP_0653"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0653"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="992" mass="113090" checksum="343629D9F5DC2A76" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1M5</accession>
    <name>A0A1W1I1M5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative enzyme with nucleoside triphosphate hydrolase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybeZ</name>
        <name evidence="5" type="ORF">NSJP_0723</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0723"/>
    <dbReference type="EnsemblBacteria" id="SLM46895">
        <property type="protein sequence ID" value="SLM46895"/>
        <property type="gene ID" value="NSJP_0723"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0723"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="4">
        <location>
            <begin position="107"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="356" mass="39248" checksum="483A2FEC4DEB61EC" modified="2017-06-07" version="1">MKKLKLREGTNTAVLFGHHDRHLKLIEDDLGVRLSARGEELTVDGSPDATRHAERVLTELAALASEGMVLQPEDIAHALSALKQSPDAPLKELLSTATTIVTKKRFVAPKTPTQKSYIEAIETHDIVIGIGPAGTGKTYLAMAMAVSALMKRQVSRIILARPAVEAGEKLGFLPGDMYAKVNPYLRPLYDALFDMMDMERATRAIERGDIEIAPLAFMRGRTLNDSFVILDEAQNATAEQMKMFLTRLGFSSKAVVTGDITQIDLPPERVSGLIEVRDILSEVEGIRFIYFDERDVVRHKLVQDIIKAYDQHQHQEGIQDPTASPQGRRPPPSSHPRSSPPPTTQPSPKSSVGQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1N3</accession>
    <name>A0A1W1I1N3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Type IV pilin PilA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0730"/>
    <dbReference type="EnsemblBacteria" id="SLM46902">
        <property type="protein sequence ID" value="SLM46902"/>
        <property type="gene ID" value="NSJP_0730"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0730"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="142" mass="14991" checksum="0CAB6ADAC3AA5624" modified="2017-06-07" version="1">MVELMIVVAIIGIASIIAVPAINEWLARYQLKQAMSEVSGDLNLAKLVAMNRNRQATVTIQLSGALIEVSGVSGGQQIFPTRTLMPRVTTLPGGTATVNFSSMGLSTATASQTIQIQNERGLVYALLVLPSGKVSWCAKASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1P7</accession>
    <name>A0A1W1I1P7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46789">
        <property type="protein sequence ID" value="SLM46789"/>
        <property type="gene ID" value="NSJP_0617"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0617"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="80" mass="8982" checksum="C1CC3EC29982AB65" modified="2017-06-07" version="1">MDFSESTFDFDHLVMGELSVDQHIAVAVLCFRYCLQTDPETLEDAKDLRRRVLMACSVTSADCDTIISRATKIAIAKESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1S5</accession>
    <name>A0A1W1I1S5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized ferredoxin-like protein YfhL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yfhL</name>
        <name evidence="5" type="ORF">NSJP_0773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0773"/>
    <dbReference type="EnsemblBacteria" id="SLM46945">
        <property type="protein sequence ID" value="SLM46945"/>
        <property type="gene ID" value="NSJP_0773"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0773"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="115" mass="12372" checksum="C84D97FA54AE3DC6" modified="2017-06-07" version="1">MALLITDECISCGACLPECPNEAIFETRSDAETKGNHVGDGQGVGDNIYVITHDRCTECVGHFDEPQCAAVCPVDNCCISDPAYPETTDVLLEKAKSLNPDKTIDPAKIWSGVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1T8</accession>
    <name>A0A1W1I1T8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46976">
        <property type="protein sequence ID" value="SLM46976"/>
        <property type="gene ID" value="NSJP_0804"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0804"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012235632" evidence="1">
        <location>
            <begin position="27"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="193" mass="20838" checksum="11DEF8E36E2B2C0A" modified="2017-06-07" version="1">MRPRDVYRVVATLAMIWTAMPALSNASEQADVDLGTMWSCPLPDGTVLYTNKDRKNKDGCTPMSLKPLSVVPSLDAMPTYRPPVASAPQYDIPAIDRGAGPSGSAAAPDWAKDWHASVTSSGSVQAEVCSIYSEWLQLNQKSRGGFYFGSDPSYGGDVSAQNQRGPSYSFYDNARYHTLARIFGTGFVPVGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1U1</accession>
    <name>A0A1W1I1U1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46965">
        <property type="protein sequence ID" value="SLM46965"/>
        <property type="gene ID" value="NSJP_0793"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0793"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019099">
        <property type="entry name" value="Uncharacterised_PGPGW_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09656">
        <property type="entry name" value="PGPGW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="143" mass="15950" checksum="8731AD2E2DC5CA10" modified="2017-06-07" version="1">MDWLLSTVEQVVSTDTLIALTVLSLIFFVGTLIAIPFILVRLPADYFDVRVPRPWMENHHPVLRMAGHLVKNILGAVFVFVGFLMLFLPGQGILTMLIGISMLDFPGKRRVEAKMIGQPTVLGAVNAMRRKFQKPPLVLAPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1W9</accession>
    <name>A0A1W1I1W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46984">
        <property type="protein sequence ID" value="SLM46984"/>
        <property type="gene ID" value="NSJP_0812"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0812"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="20" mass="2231" checksum="6BDCC2898B86D7DE" modified="2017-06-07" version="1">MEGETVVSGRIAIEELIRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Z4</accession>
    <name>A0A1W1I1Z4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase_H_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0845"/>
    <dbReference type="EnsemblBacteria" id="SLM47017">
        <property type="protein sequence ID" value="SLM47017"/>
        <property type="gene ID" value="NSJP_0845"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0845"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="86" mass="9438" checksum="FE44F373A603E4E5" modified="2017-06-07" version="1">MAASKAIEAQLGISRASTVQGLDGSDAVVLWNRWRHRRDSDARERLVAYNRADCVNLEPLAERFYASMAGLVLRDVLLKHSGGSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I223</accession>
    <name>A0A1W1I223_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47042">
        <property type="protein sequence ID" value="SLM47042"/>
        <property type="gene ID" value="NSJP_0870"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0870"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="38"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="206" mass="23486" checksum="F33699D6474A0BA3" modified="2017-06-07" version="1">MGLYSSYVFPHLMDWLMRGKEFQRLRDDLLTVVRGDVLEIGFGSGLNLAHYPPTVHHLTAVDPARFLPDIVARRTAAVAFPVEIHHHAAETLSFADQRFDWVVSTWTLCSIADPVQALTEVRRVLKPDGRFVFLEHGRCQDERVAAWQDRLNPIQNVLGCGCHLNRRIDRLVEHGGLRLMQLDRFPMADVPQLVGAMYRGWAEPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I276</accession>
    <name>A0A1W1I276_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase cytochrome B subunit, b558 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sdhC</name>
        <name evidence="8" type="ORF">NSJP_0944</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0944"/>
    <dbReference type="EnsemblBacteria" id="SLM47116">
        <property type="protein sequence ID" value="SLM47116"/>
        <property type="gene ID" value="NSJP_0944"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0944"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011138">
        <property type="entry name" value="Cytochrome_b-558"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02046">
        <property type="entry name" value="sdhC_b558_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="225" mass="24555" checksum="D3681141C3DAF5A1" modified="2017-06-07" version="1">MTRFFTVFCTSLGSKVVVALTGLVLAGFVVFHMLGNLQVFEGQEALNTYAAFLRELPILLWSARIGLLLTAALHIGLTIQLVIRNRRARPVAYASRVYRQASISSRTMALTGTLVLLFIVFHLLHLTAGVVDTSFVDRLDPRGHRDVYSRVIHTFQNPWFALLYLLAQGVLAVHLSHGVSSSLQTLGLEHPVLNRVFRAAGPFVAGTVALGNSAIVLAIALGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2D4</accession>
    <name>A0A1W1I2D4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitrogen regulatory protein P-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glnB</name>
        <name evidence="1" type="ORF">NSJP_0996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0996"/>
    <dbReference type="EnsemblBacteria" id="SLM47168">
        <property type="protein sequence ID" value="SLM47168"/>
        <property type="gene ID" value="NSJP_0996"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0996"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="113" mass="12577" checksum="5582464FAF491E38" modified="2017-06-07" version="1">MGELVLHPMKEIRVIVAGEHRAFVTELLDRVNASGYTIIGNVSGKGHHGVREAHFMFSEQESLEMIMTVVPEDKVEPILAGLRPLFERHSGVMFVADVAVSRQEYFGKKSKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2D6</accession>
    <name>A0A1W1I2D6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47029">
        <property type="protein sequence ID" value="SLM47029"/>
        <property type="gene ID" value="NSJP_0857"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0857"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="76" mass="8546" checksum="D07D880E62D4A5B2" modified="2017-06-07" version="1">MEWIAIIIFAAASFAYGRNVGMKHGYDELGPKELSGMIDFYSRLVRTEGYETVAARTGDPLMRNLVEVIHEASKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2F7</accession>
    <name>A0A1W1I2F7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">gyrB</name>
        <name evidence="13" type="ORF">NSJP_1005</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1005"/>
    <dbReference type="EnsemblBacteria" id="SLM47177">
        <property type="protein sequence ID" value="SLM47177"/>
        <property type="gene ID" value="NSJP_1005"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1005"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041423">
        <property type="entry name" value="GyrB_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18053">
        <property type="entry name" value="GyrB_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="433"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM47177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="829" mass="91766" checksum="3FC49DF5D65F2DC4" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2G7</accession>
    <name>A0A1W1I2G7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47206">
        <property type="protein sequence ID" value="SLM47206"/>
        <property type="gene ID" value="NSJP_1034"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1034"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="85" mass="9834" checksum="A433F89F909660C4" modified="2017-06-07" version="1">MWISTMGGTLGQCCETRWRTSDGDTIFLLRNHSSRSGSPLSRKQTLNEFTHATTMNSLPVPKSRRLPEYRQADNRHSRRGVRRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2R4</accession>
    <name>A0A1W1I2R4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47113">
        <property type="protein sequence ID" value="SLM47113"/>
        <property type="gene ID" value="NSJP_0941"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0941"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="68"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="180" mass="20262" checksum="0C4BF159E0DC16B5" modified="2017-06-07" version="1">MPVTFDDAMARLLHCPQCRQEKILREQPVSAGERVAALLMMSPFSCQHCSCRFMASRIGVVMPEHKTERRQHLRIPVRLYLSFSGGKVRGEGIVMDLSVGGCIIKSDTLVHVDDIFYLEITTDQDQAPLEVAAMVRSVSQRGIAFKFLRAAQENKRLLAFVQSRSVEHHDRLAPKLRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2X1</accession>
    <name>A0A1W1I2X1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1001"/>
    <dbReference type="EnsemblBacteria" id="SLM47173">
        <property type="protein sequence ID" value="SLM47173"/>
        <property type="gene ID" value="NSJP_1001"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1001"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="495" mass="56269" checksum="48DCFBDEE346E767" modified="2017-06-07" version="1">MSADRPSRRVIAVAPMPPEKSAYALARYSRSPDSIESSIAWVHGHSSEKFWEQFYFDYGHASIADLGHVIVCFEDITELAAIRLEDEPVWDGQAKSSRYQNFASSGWYVPDAIHGSETEGTYQGILRSLGEIYRLLHGPLVEFLSERDPRPEAMKPGDYQRTIAARAFDVTRYLLPLASRTNVGQVVSIRTLEKQITRLLSSQLPELRMIGEDLKDACQRPPMNVWGELTGQAPGPYEPLAPTLARHAKSSEYQGAVYTDLARYAKEALRGNGLDDAASWGSQEAVELVEPHDPCDEVVATLLYRVSQAPYRHILSVVRDWTEKQKQETIEIALSRRGPYDELIREFRSGYPLTFDILMDIGGWRDLHRHRRCQQIQQNFTTRHGYETPKPLVQAGLDGEYRQAMDAVQADIEQLRKVNAEAALYAIPFGFKVRCLFKMDFAEAEYIAKLRSGVKGHWSYRSIAWLIKEKVTERYPSLGRHMQATSPDIEDTLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2X2</accession>
    <name>A0A1W1I2X2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ParB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1057"/>
    <dbReference type="EnsemblBacteria" id="SLM47229">
        <property type="protein sequence ID" value="SLM47229"/>
        <property type="gene ID" value="NSJP_1057"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1057"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="2">
        <location>
            <begin position="74"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="332" mass="36679" checksum="920402BD9F9EF96C" modified="2017-06-07" version="1">MAAEKRKKGSGSTGVKRRKRPAGASIGLEPTELQAAAPPGVVAELHRAIEEDGGKVLAVYREPYGGRWLVLAALPIELVEPTPYQRNLSDTHVRKLEAVIGKIGSFLDPIIAVRLTKPDQIAKYWTPNGNHRLSAMRTLGAKSIVAIVVPEPAAAYQILALNTEKAHNLREKALEVIRMYKELAQLEDIAEEAYALEFEEPSLITLGLCYEDRPRFSGGAYHPVLKRVEEFLRQPMRGGLERRREMAKVLLALDDEIVKHVEALKTRGLASPYLKSFLVARVNPVRFRPKDAAPLSFDEALDRMAKAAAKFDPDKVKPNDLARSGGAPDEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Z4</accession>
    <name>A0A1W1I2Z4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47193">
        <property type="protein sequence ID" value="SLM47193"/>
        <property type="gene ID" value="NSJP_1021"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1021"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="52" mass="5765" checksum="1CBB79D147573A3D" modified="2017-06-07" version="1">MRKWEAPAFSEIRMDAEINGYQEDRDDIPDLGQEPHAPGIAAAQQERPAAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Z6</accession>
    <name>A0A1W1I2Z6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47380">
        <property type="protein sequence ID" value="SLM47380"/>
        <property type="gene ID" value="NSJP_1208"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1208"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="64" mass="7282" checksum="66D67EDC6C5FEFF7" modified="2017-06-07" version="1">MTIMRAQPGHRRKPVRDVAMKCRRNAPAGQSKTAAEKLEEEVQEFNKHIANPKERTRVIPSSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I317</accession>
    <name>A0A1W1I317_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized oxidoreductase YxnA</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yxnA</name>
        <name evidence="2" type="ORF">NSJP_1212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1212"/>
    <dbReference type="EnsemblBacteria" id="SLM47384">
        <property type="protein sequence ID" value="SLM47384"/>
        <property type="gene ID" value="NSJP_1212"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1212"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="355" mass="38702" checksum="F49B95E80D8EDACE" modified="2017-06-07" version="1">MSLRLKPIREQVIVITGATSGIGLVTARLAASRCGRLILTGRNEAALRELSQEIQGNESHGGVAHFVPADVADEAALRRVADEAIRRHGRIDTWINCAGVSTYGRLMDVPVADQRRVFDTNFWGVVHGSRIAVEQLRTHGGALINIGSAVSDRAIPLQGPYCASKHAVKAYTDALRMEIEHDGLPISVTLVKPCSVDTPFADHARNYLTSQPQNPPPLYAPEVVAQTILSCAERPVRDVFVGVEGKLLAMMEHAFPRLTDKIMERSFFRAQHTRRPARRTRQDSLYRTPADAELKERARGRVGVSASSFYTEASLRPFVTGAMIAAAGITAAALFGRGGSSSRHTGILPHTFERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I345</accession>
    <name>A0A1W1I345_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1258"/>
    <dbReference type="EnsemblBacteria" id="SLM47430">
        <property type="protein sequence ID" value="SLM47430"/>
        <property type="gene ID" value="NSJP_1258"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1258"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1120" mass="120385" checksum="3B80AAC000A4DD57" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I373</accession>
    <name>A0A1W1I373_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1286"/>
    <dbReference type="EnsemblBacteria" id="SLM47457">
        <property type="protein sequence ID" value="SLM47457"/>
        <property type="gene ID" value="NSJP_1286"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1286"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="156" mass="16757" checksum="15C2D82E2634B6BA" modified="2017-06-07" version="1">MGMKVAVGKWVFYGSSHHFGRCSIMTYCVSVEEIRPQAYSTGGLTSTTIRNLVVSWCSTELEWAASAACSVSTLRSQVTRHVRGYLGLLWRTGALRGKQPHDAFNVTCDGPTTSHPDIGQNSLVCRVGIAPAGSSGSVFLLIRIRLRSPSTPLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3C8</accession>
    <name>A0A1W1I3C8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit J</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nuoJ</name>
        <name evidence="2" type="ORF">NSJP_1303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1303"/>
    <dbReference type="EnsemblBacteria" id="SLM47475">
        <property type="protein sequence ID" value="SLM47475"/>
        <property type="gene ID" value="NSJP_1303"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1303"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="173" mass="18832" checksum="CBCA53FD54769352" modified="2017-06-07" version="1">MISLFFAYFALMSIAAAVMTVALKNPVHCGLALLALLLHVSGLFILLNAEFLWAVQVVVYAGAILVLYLFVLMLLNLKTEERYFHTSWTYFLVPAVLGSLYVLVQLFRSPFGGAKGDAPAQAILQDGNTFAVGIKMFSDYLLQFEIVGVFLLGAIIGAIVLAKTPKPVDAGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3R3</accession>
    <name>A0A1W1I3R3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1485"/>
    <dbReference type="EnsemblBacteria" id="SLM47657">
        <property type="protein sequence ID" value="SLM47657"/>
        <property type="gene ID" value="NSJP_1485"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1485"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="423" mass="45580" checksum="79F21488BC9D5568" modified="2017-06-07" version="1">MPCTRHHSRVENPESFRVWTGWAVPYRESGRVGRQPYWHASFVVCALFIVLSSLACSKQDPYVPPDLLYYFASYKVGKNPTTITTMDVNQDGLTDLVTTNIASDTLSILVGNGDGTFRDQLQLHVCQEPRSLATGLFNADTHPDIVLACSGSDQIAILFGRADGKFDEGPQYPVHRTPIAVASDDLNGDHAADLVVALRNDKIKIFLGLGNGEFKHGPQYEYGDTPTSVALSDLNGDSIPDVVVTNGGPMSNAVSIWIGNGDGTFRMPTDYKSGKRPLGVSFADFNNDKIRDLLVINGERDSFSTFLGNGNGTFQPGRDSGADAGPNFGLARDFNGDRRTDVAIVNLQSNDLSILFGRGDGTFEYPPRNYKTKSGPFAVAVFRATTKDAEEPGLVTADNGAGTVSVFLHRGLKSPVPPAVAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3X3</accession>
    <name>A0A1W1I3X3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47702">
        <property type="protein sequence ID" value="SLM47702"/>
        <property type="gene ID" value="NSJP_1530"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1530"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012031797" evidence="2">
        <location>
            <begin position="23"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="80" mass="8323" checksum="D36A888CF4E82FC0" modified="2017-06-07" version="1">MTVRWLLWLSVGLSASCGTVGAPIAPENVGVAVTIEQQKRLDASGGPRPGAVAPVERRDSDPVPEGQDVNLPPLRPVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Y0</accession>
    <name>A0A1W1I3Y0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BNR repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1555"/>
    <dbReference type="EnsemblBacteria" id="SLM47727">
        <property type="protein sequence ID" value="SLM47727"/>
        <property type="gene ID" value="NSJP_1555"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1555"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="345" mass="37430" checksum="D58E8EE86A335855" modified="2017-06-07" version="1">MRLIPRMSLLVPVVLLLIVCMTGCQKDSEAIVSIALHPTNSNIVYVATNDAVYKTRDGGRLWERFPSFSARRVTTVALDPQLPATVYAGTMGDAVYKSPDGGQHWLPHNVGLKEHVSFVNQFVFHPVLSEKIYAATTVGAFYTKDAGREWEERMNGMKEVHIVTSIAINPKDPTILYGGTTGGVYRSDDAAMSWKKVNTGLIPESELMASMALGVNAIEIDRINPDVVYAGTTKGLFRTANKGTEWNRIGQSLPDPFVSSIVIHPTQPSVVYIGGPGGVWKSTDSGATWQAMNQGLSTLNIRALAMSRQNPQTLYVGTNGSGLYRSTDGGTTWTPLPLTTAPART</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4S2</accession>
    <name>A0A1W1I4S2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c biogenesis protein CcdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ccdA</name>
        <name evidence="3" type="ORF">NSJP_1824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1824"/>
    <dbReference type="EnsemblBacteria" id="SLM47996">
        <property type="protein sequence ID" value="SLM47996"/>
        <property type="gene ID" value="NSJP_1824"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1824"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="9"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="244" mass="26386" checksum="91471333CC61B4B3" modified="2017-06-07" version="1">MSNISLIAAFSAGLLSFVSPCVLPLVPSYISYITGLSIEELTDAGTRSRFRSEIVANALLFIAGFSAVFIAFGASASFVGQLLITYQDHIRRIGGVLIVIFGLYLLGILNINFLQMEHRFQFRNRPVGYAGSFLIGIAFAAGWTPCVGPVLGTILLYASTTDSLMTGVLLLTSYSLGLGLPLFLTALGVDRFLAYFKQARAYLWGVSTVSGVLLVVVGIMIYANSLTMITSFLERYGIGWYLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4U2</accession>
    <name>A0A1W1I4U2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">ispG</name>
        <name evidence="6" type="ORF">NSJP_1844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1844"/>
    <dbReference type="EnsemblBacteria" id="SLM48016">
        <property type="protein sequence ID" value="SLM48016"/>
        <property type="gene ID" value="NSJP_1844"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1844"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="352"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="393" mass="42311" checksum="47ED7A78F44A47E5" modified="2017-06-07" version="1">MHITRRQTRQIQVGKVKVGGDAPVSVQSMCSTDTRDVAATVEQIRQLETAGCELIRVAVPDEEAAAALPKIKAAMTVPLIADIHFDHRLALQAAQIVDCVRINPGNIGAWWKVEEVIKAVNDRGIPLRVGVNGGSLERPLLDKYGWPSPEALAESALNAVHALEDVGFTNMKVSLKASDVHHAIDAYWLFAHQSNYPLHIGITEAGTAMTGAVKSAMGLGYLLSQGIGDTMRVSLAADPVEEVKVGFEILKSLELRHRGINVIACPTCGRVEIDVVRMANELEKKLGHIKTPLNVSVLGCVVNGIGEGKEADIGIAGGEGKGILFKKGKLVRKVPIEELMDTLIQEVESLAREKEAEGGGDAHGHADERWEPLVPQPDQPSTLGREIPVLPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4V8</accession>
    <name>A0A1W1I4V8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="6">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="6">DXP synthase</shortName>
            <shortName evidence="6">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">dxs</name>
        <name evidence="8" type="ORF">NSJP_1843</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="6">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1843"/>
    <dbReference type="EnsemblBacteria" id="SLM48015">
        <property type="protein sequence ID" value="SLM48015"/>
        <property type="gene ID" value="NSJP_1843"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1843"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="7">
        <location>
            <begin position="315"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="6">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="6">
        <location>
            <begin position="146"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="649" mass="70252" checksum="98CC4F4067E44479" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Y6</accession>
    <name>A0A1W1I4Y6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Ferric uptake regulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48045">
        <property type="protein sequence ID" value="SLM48045"/>
        <property type="gene ID" value="NSJP_1873"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1873"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="139" mass="15909" checksum="ED257EFB59E4F7FA" modified="2017-06-07" version="1">MNTSSLTHRLKASGKKLTQARQAILTILEGSQLPITAAEVHARLMKAHMPADRVTVYRNLSLLEKLRLVNTVGFHDGQMRYEIHSGREHHHHIQCLTCGKIADLMLCPLEKLTQLVEKQTRFSVDRHALEFFGWCPQCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5A9</accession>
    <name>A0A1W1I5A9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transporter, auxiliary component, ATP-dependent toluene efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1841"/>
    <dbReference type="EnsemblBacteria" id="SLM48013">
        <property type="protein sequence ID" value="SLM48013"/>
        <property type="gene ID" value="NSJP_1841"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1841"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008869">
        <property type="entry name" value="MlaC/ttg2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042245">
        <property type="entry name" value="Tgt2/MlaC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36573">
        <property type="entry name" value="PTHR36573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05494">
        <property type="entry name" value="MlaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004649">
        <property type="entry name" value="MlaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="213" mass="24046" checksum="A2719B8A56898FCC" modified="2017-06-07" version="1">MPRYVVQRWKKIGFVMGATIALTAMIVGIGLRPAAAGGATEAMKSTIDEVLKILGDKDLKHPEKSAQRRKMLEKVVGDRFDYAEMSRRSLGSTWTGLSAPEREEFVGLFQTLLVSTYAEKVETYSGEGVHYLSERTEKDYAEVRTKVLTGKTEIPLDYRLLNRDSVWRVYDVVVDGVSLVNNYRGQFSKILKNGSFAELVDQLRKKSEKIRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5E2</accession>
    <name>A0A1W1I5E2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphodiesterase/alkaline phosphatase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2066"/>
    <dbReference type="EnsemblBacteria" id="SLM48238">
        <property type="protein sequence ID" value="SLM48238"/>
        <property type="gene ID" value="NSJP_2066"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2066"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013003685" evidence="1">
        <location>
            <begin position="37"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD_N" evidence="3">
        <location>
            <begin position="59"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD" evidence="2">
        <location>
            <begin position="190"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="507" mass="55085" checksum="3719239D7DE6A5CD" modified="2017-06-07" version="1">MPAFRYGSVSGPKPVKLLALCLVAVAALTSCTSASSEVFHSDRPISQTTAPTETLLPEGLAVGDMTSRSAVLWLRTDGSKAVQVLWAPLDDWKKMGAMASVRPAVPETPVLVTRPETDFTLSVPLEHLAPATRYRYRVLVDSVEQASGSLRGTLAATGEFTTLPEPEQSVPLSFAWSGDLGGQDRCRQGEAGYPIFDGMAAQHPDFFVFLGDTIYADGVCSAPPNEPGAGFVATNLQEYRLRHRYQRGASALRRLLSGVPVYVIWDDHEVRDNFSGPYEPRMAAGRQALREYWPIAMQAGDPDRLYRSVRYGANLELFILDTRQYRSKNADPDGPEKTMLGPAQLAWLLDGLRKSTATWKAVVTSVPLSIPKGGGGAAPGYDGWSGGPAGGSDGTGFERERQVIVDHILADRIKNVVFLAGDVHYVQANGYDPDNDGRIDFHEFVSGPLSARFGRMTPPTPSLHPTVLLNDGGYSNFGLVRVTAESFEVAFVDDTGKTRFSHRLQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5J2</accession>
    <name>A0A1W1I5J2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gapA</name>
        <name evidence="10" type="ORF">NSJP_2115</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2115"/>
    <dbReference type="EnsemblBacteria" id="SLM48287">
        <property type="protein sequence ID" value="SLM48287"/>
        <property type="gene ID" value="NSJP_2115"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2115"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM48287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="337" mass="36425" checksum="C3B30DC14F9F7DEA" modified="2017-06-07" version="1">MAIRVGINGFGRIGRNVLRASLGDPELEFVAINDLTDAKTLAYLLKYDSVHGTLKGTVEAKDDQILVDGKATKVLAVKDPKELPWKDLNIDVVIESTGRFTDRESAGKHLSAGAKRVIISAPAKDPDVTIVLGVNDNTFDPASHLIVSNASCTTNCLAPVAKVLLENFGIKHGIMTTIHSYTNDQQLLDLPHKDLRRARAAGMSMIPTSTGAAKALHLVIPQLKGKMDGLAIRVPTPNVSLVDLTVETEKDCDVASVNEAYRKAASGPLKGILEYSEAPIVSIDQKGDDHSATVDAPLTAVIDKRLVKVTAWYDNEWGYSCRVRDLIKVIVAKTKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5J6</accession>
    <name>A0A1W1I5J6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48282">
        <property type="protein sequence ID" value="SLM48282"/>
        <property type="gene ID" value="NSJP_2110"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2110"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="21"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="125" mass="13817" checksum="3F27496AF90D8ACE" modified="2017-06-07" version="1">MAINSQAKNSSRLIPTKFVLRTYRRIPTWCASYYLSGSAIGKGIVTNLSRCGMRMLGDHAPKTGTDLCVRLHLDDDQPPIEIARATVRWVGQGEFGLQIDDLTAAVAGRIAEMLNRQARTGRNGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5N8</accession>
    <name>A0A1W1I5N8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2144"/>
    <dbReference type="EnsemblBacteria" id="SLM48316">
        <property type="protein sequence ID" value="SLM48316"/>
        <property type="gene ID" value="NSJP_2144"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2144"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="211" mass="24357" checksum="32C1E9DB4448AF52" modified="2017-06-07" version="1">MRIDYYRVLGVSREASDEAIKKAYRKLVFEHHPDRNPNSRTAEARIREINAAYEIVGDPEKRRSYDRLHWGDETRDDVVDTAVILDEMEKKLFDEGRKELFAVLMKNVRRIKDELAVIRERTVADQGYDSFKETIIHARAAETLEEFITDEMAGRADRLVEVAAQMMVSQGVVGKNDEPGMRALRKGLGAMIRKGRIHGFAAALELFYERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I672</accession>
    <name>A0A1W1I672_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor G</fullName>
            <shortName evidence="6">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">fusA</name>
        <name evidence="8" type="ORF">NSJP_2335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2335"/>
    <dbReference type="EnsemblBacteria" id="SLM48507">
        <property type="protein sequence ID" value="SLM48507"/>
        <property type="gene ID" value="NSJP_2335"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2335"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
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        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="2"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="678" mass="75283" checksum="AE0D2517761684FE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I689</accession>
    <name>A0A1W1I689_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="NSJP_2323"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="72" mass="7961" checksum="570FCC039A7B6E0B" modified="2017-06-07" version="1">MEWFQARLIDCSMQRPRVSGLPDAARGSELEGVMYGEGEIRAEEAACEHRDDWARGSREDDVDGGVDESVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6I2</accession>
    <name>A0A1W1I6I2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative lipopolysaccharide transport protein B: ATP-binding component of ABC superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lptB</name>
        <name evidence="5" type="ORF">NSJP_2369</name>
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        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03218">
        <property type="entry name" value="ABC_YhbG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="LPS_export_LptB"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04406">
        <property type="entry name" value="LPS_export_lptB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="24"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="260" mass="28241" checksum="F547CB42031D78C3" modified="2017-06-07" version="1">MTEVAHASATASTAAGSGSRKTALQATGLMKSFRSRKVVKGVSVEVHAGEVVGLLGPNGAGKTTIFDMMVGLTQPDEGTITLDGEPLTSLPMYKRARKGIGYLPQESSIFRRLSVEDNILAILEMLDYSRSERAERVEILLKELDLGHIRTSMAYALSGGERRRLEITRALATNPSFMLLDEPFAGIDPIAVADIQQIITRLKEKGIGILITDHNVQETLSITDRAYIINEGLILEAGSPEAIVRSETARAVYLGDRFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6K5</accession>
    <name>A0A1W1I6K5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48642">
        <property type="protein sequence ID" value="SLM48642"/>
        <property type="gene ID" value="NSJP_2470"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2470"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="107" mass="12283" checksum="0B4C8C65D34CB99C" modified="2017-06-07" version="1">MGLLQRLKHDLKAGLATLRLGTAQAANRALEETELLRLRLEARKIDQRLIEFYRDLGERAVDLREAGEPAERVLYDAEVGRLVAEIHQLKHAGRKLEAEMREIRNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6V7</accession>
    <name>A0A1W1I6V7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48599">
        <property type="protein sequence ID" value="SLM48599"/>
        <property type="gene ID" value="NSJP_2427"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2427"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005625">
        <property type="entry name" value="PepSY-ass_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34219">
        <property type="entry name" value="PTHR34219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03929">
        <property type="entry name" value="PepSY_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="385" mass="42956" checksum="3578FBD6CE1EAE65" modified="2017-06-07" version="1">MTIVAFKKWYVVHKWTSLVCTLFLLLLCLTGLPLVFRDELSVWLGEAVEPPEQVVATKSVTLQALVDDAQRRRPSDAVQFLTLDDEHPAWFVSLGASPAAIDSSGIYMYDTRTGDFLHAVPTNTGVTNFFFKLHTELFAGLPGMLFLGSMGLLFLGSTVSGVVVYGPFMRKLAFGTIRQERHLRLTWLDLHNLLGITTLLWALVVGVTGVVNTLERPLLGYWQQTELAGMLAPWSGKPAPRTLLPVDRVIEAAQAAAPDLVPRFVGFPGTVIATPYHYVVFMRGQNPLTSRLLTPFLFDAETAQLADTRSLPWYLTVLVLSQPLHFGDYGGMPLKIIWGMLDLLIIIVLVSGLYLWWRKRPFALEHVVDDGESKARHGFDRVVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6W3</accession>
    <name>A0A1W1I6W3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48740">
        <property type="protein sequence ID" value="SLM48740"/>
        <property type="gene ID" value="NSJP_2573"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2573"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012664276" evidence="1">
        <location>
            <begin position="18"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="240" mass="26287" checksum="9A7F6B6923C66AF9" modified="2017-06-07" version="1">MRAVVIAWLAMILAGCAASKGFDRGTLRDSLGQVTTDKDIQEVLALKPQLPAPFKLGVFLNSNRSNYKTRVWTDEEKNDLLTYGNRLKEAGVVSVIYLISEDTIPGHYGSGYVSTSNRDALKDLRLEAARYGADALLVITDVSSVDRYNNPAALLYLTIVGAYLVPGTQSDALVMMRSSLWDVRNGYLYATQDAEGIGKRIGPAFVTEDTDSVYAAKKMAIADLGRKLTDRLIQLNAQMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Z2</accession>
    <name>A0A1W1I6Z2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2603"/>
    <dbReference type="EnsemblBacteria" id="SLM48770">
        <property type="protein sequence ID" value="SLM48770"/>
        <property type="gene ID" value="NSJP_2603"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2603"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009874">
        <property type="entry name" value="DUF1428"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07237">
        <property type="entry name" value="DUF1428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007028">
        <property type="entry name" value="UCP007028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="119" mass="13679" checksum="E67C4000700C809C" modified="2017-06-07" version="1">MGYVDGFLLPIPKKNIERYRRIARQAEKIWREHGALDYKECVGDDLMTKMGIPFPKSAKAKTGETVIFAYIVYKSRAHRDRVNAKVMKDPRIHSMGDHKDMPFDCKRMAYGGFKVLVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I721</accession>
    <name>A0A1W1I721_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2608"/>
    <dbReference type="EnsemblBacteria" id="SLM48775">
        <property type="protein sequence ID" value="SLM48775"/>
        <property type="gene ID" value="NSJP_2608"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2608"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="23"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="135" mass="14753" checksum="985BFA620EEB9925" modified="2017-06-07" version="1">MAKSGKKSTRSELAASVCWFEVPADDLDRAKGFYGSLFGWTFDKIPAAIAEYWHIDTGGKDATPDGGLMPRMHPGQSITLYVSVPSVEKAMEKVKKLGGTVCQPKTAVPHMGYLAICRDTEQNTFALWEPNEQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7D2</accession>
    <name>A0A1W1I7D2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclophil_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48831">
        <property type="protein sequence ID" value="SLM48831"/>
        <property type="gene ID" value="NSJP_2664"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2664"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025658">
        <property type="entry name" value="Cyclophilin_TM1367"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04126">
        <property type="entry name" value="Cyclophil_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclophil_like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="129" mass="14168" checksum="08C5F17C7E9B30AB" modified="2017-06-07" version="1">MTSEPPKKIRITVGPVQVEAELKSTRTAREVYAALPVEAPVNVWGEEFYFKLGGVKDHRETATTQVKVGDVAFWGAGQVLAVFFGRTPMSMGSDPVPADRVNVIGRIVGDATVLRRVMEDARTIRVEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7D9</accession>
    <name>A0A1W1I7D9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_hydro_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2759"/>
    <dbReference type="EnsemblBacteria" id="SLM48926">
        <property type="protein sequence ID" value="SLM48926"/>
        <property type="gene ID" value="NSJP_2759"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2759"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="2">
        <location>
            <begin position="39"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="347" mass="38418" checksum="0637ED44A6306B64" modified="2017-06-07" version="1">MTEPVPPSMDDRPAIGHCFLLGFRGTEIPPWLRQFAGTHGLGGVILFDFNCQTKTYDNNIRNPEQVRDLCAEISALPSGPLLFVDQEGGRVRRLKDEQGFAPLPSQQTFSRLPPEEKRRLIGDSFQELARLGFHYNLAPVIDLNFNPLNPDIGAVERSYSIEPAIVRDNVRILDAAAKAAGIGLSLKHFPGLGGATVNSHRELTDLSDTISDDQLELFYQFGESISGESIVVSHGIVRQWEEGTPVSMSPIAIAKLRQRLPRALLISDDLHMQGLQKKYQTGEACAVGLRAGLDMLCIGNNLMPEDELVLSYAKAICRQMRTDAFLADQVRLAVARVAKAKRRFNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7E8</accession>
    <name>A0A1W1I7E8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2769"/>
    <dbReference type="EnsemblBacteria" id="SLM48936">
        <property type="protein sequence ID" value="SLM48936"/>
        <property type="gene ID" value="NSJP_2769"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2769"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007298">
        <property type="entry name" value="Cu-R_lipoprotein_NlpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005184">
        <property type="entry name" value="DUF306_Meta_HslJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038670">
        <property type="entry name" value="HslJ-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033450">
        <property type="entry name" value="NlpE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038139">
        <property type="entry name" value="NlpE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03724">
        <property type="entry name" value="META"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04170">
        <property type="entry name" value="NlpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17185">
        <property type="entry name" value="NlpE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="NlpE_C" evidence="2">
        <location>
            <begin position="165"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="META" evidence="1">
        <location>
            <begin position="259"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="374" mass="42157" checksum="B0D77B40F3D0ABA7" modified="2017-06-07" version="1">MLGCRRNNAFKECAGQQKGLLDEVSVLRCDAPVVPRLLGGMRRRGPDRPTGPLGSLPATYAGDLPCADCASLRYKLTLFPDQVYFLSRTYLGKDASPVVYDIGNWTLSDNRKVLTLTGEREQIFRFTVSGEEELHLRGLDGRDIESQLHYTLIRSPRVEPIEPRTVMRGMYRYMADAGTFKECLTGRRWPVSQERNNADLERAYSNERRQPNEELLVVLEGSVVMRPAMEETAAGETLVVERIIELRPRETCGARFATDPLENTYWKLTRLGTVPVVVTEHQREPSLVLHADNHRVAGSGGCNRLMGSYVVEGRTLHFNHMASTKMACPEGMQQEQAFLDALNNTATWKIAGEHLELYDDQGTTLARFEATHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7G4</accession>
    <name>A0A1W1I7G4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48925">
        <property type="protein sequence ID" value="SLM48925"/>
        <property type="gene ID" value="NSJP_2758"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2758"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="215" mass="24147" checksum="F3ABEDAE021D923A" modified="2017-06-07" version="1">MARRLPRHVYHLAEAANWPSIQRYGLLPAQVLVDRSGIKGRERAHLLGEQRKRHVVLAGGYELRDQRPMPPEALARCLVGMTPADWYRLINAHVYFWPDHARLNRQRTACGVRPQVVLVVDAESLVARYGSRTVLTPINSGHARRRPAVRGAATFVPYEAWLADGWASEAAALQQKTRSSSHRPAELAVEGPILDMTRYLVRVVELAGDRPFVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7S5</accession>
    <name>A0A1W1I7S5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyphosphate kinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_2868</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2868"/>
    <dbReference type="EnsemblBacteria" id="SLM49035">
        <property type="protein sequence ID" value="SLM49035"/>
        <property type="gene ID" value="NSJP_2868"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2868"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016898">
        <property type="entry name" value="Polyphosphate_phosphotransfera"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022486">
        <property type="entry name" value="PPK2_PA0141"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028756">
        <property type="entry name" value="PPK2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03707">
        <property type="entry name" value="PPK2_P_aer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="4">
        <location>
            <begin position="11"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="267" mass="31703" checksum="D710F0B77BB2467B" modified="2017-06-07" version="1">MSQKDSDKSKLKRKEYERELRKLQAELCHLQAWVKEKGLRIIVVFEGRDGAGKGGTIRAITERVSPRVFRVVALPAPSDREKTQMFMQRYVQHFPAAGEIVIFDRSWYNRAGVEYVMGFCSKEDHRRFLDLCPIVERYVVDGGMTLVKYWLEVSNEEQERRFEARLEDPLRQWKLSPMDLPSREKWYEYSRARDMMLEKTDTKHAPWHIVRSDDKKRARLNCISHLLSLIPYKKLPREKVKLPGRSKKHKYDDQASLKGRRFIPAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7X2</accession>
    <name>A0A1W1I7X2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2939"/>
    <dbReference type="EnsemblBacteria" id="SLM49106">
        <property type="protein sequence ID" value="SLM49106"/>
        <property type="gene ID" value="NSJP_2939"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2939"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="178" mass="19759" checksum="7F3D6F247A90608A" modified="2017-06-07" version="1">MHCVLFRHGIAVDREDWEGAEEDRPLTDRGAKRVAQVSEGLKWLELQPTHVFSSPLLRAIETAKILQEAHRVRSVVQIVDELLPDASPDRLLTRLSELPPESCVFCVGHEPHLGLAASLMLAGKPAMGFPFKKAGACLIEIAMPLKPGRGLLHWWMGPSQLRALGRKKLKSEKLPLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I804</accession>
    <name>A0A1W1I804_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arylsulfatase A family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49051">
        <property type="protein sequence ID" value="SLM49051"/>
        <property type="gene ID" value="NSJP_2884"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2884"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012596667" evidence="2">
        <location>
            <begin position="27"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="510" mass="57596" checksum="98A7F02D85461B0D" modified="2017-06-07" version="1">MKRMLFLMGLAMVFFSAGAMCQEAHAADKKPNILVIMGDDIGWFNPSIYHRGIMGYQTPNIDRIGHEGAMFTDWYGQQSCTAGRAAFITGQSPIRTGLTKVGLPGADIGLRPEDPSVAEILKPLGYATGQFGKNHLGDKDEFLPTNHGFDEFFGNLYHLNAEEEPENPDYPKNPEFRKRFGPRGVIHSFADGKIEDTGPLTRKRMETADEEFLAAALDFIDRQHKAGKPFFCYFNSTRMHVFTHLKKDSEGKTGLGVYPDGMVEHDGHVGQLLKKLDDLKIADNTIVVYTTDNGAEVMTWPDGGSTPFKGEKATNWEGGFRVPTVIRWPGVIKPHTIYNDMFAHEDLIPTFAAAGGDTDVVERCKKSCQSGKKSFKVHLDGHNLVPFFKGEVKESPRKEFLYWSDDGDLLALRFQNWKIAFKEQEHTGFNVWKREFTNLRFPTLYNIRADPFERGPESIEYGRWAADRMFAVVPSQAVVARWLASFKEFPIRQKPASFNLDEVMQKMSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I807</accession>
    <name>A0A1W1I807_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate transport system permease protein CysT</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysT</name>
        <name evidence="11" type="ORF">NSJP_2822</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2822"/>
    <dbReference type="EnsemblBacteria" id="SLM48989">
        <property type="protein sequence ID" value="SLM48989"/>
        <property type="gene ID" value="NSJP_2822"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2822"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011865">
        <property type="entry name" value="CysT_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005667">
        <property type="entry name" value="Sulph_transpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406">
        <property type="entry name" value="PTHR30406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406:SF8">
        <property type="entry name" value="PTHR30406:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00969">
        <property type="entry name" value="3a0106s02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02139">
        <property type="entry name" value="permease_CysT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="61"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="278" mass="29956" checksum="3F526570FF7F0B95" modified="2017-06-07" version="1">MPLILKQPSVLPGFGLTLGLATFYFSLIVLIPLSGLFIKTSTLTWEQFWSTVTEPRAMASYQLTFGASLLGALINGLFGSVVAWVLVRYRFPGRAVVDALVDLPFALPTAVAGIALTAIYAPNGWIGHLLDPLGIKIAFTPLGVLVALTFIGLPFVVRTVQPVLQDLDKEVEEAATTLGASRWQTFRAVIAPELWPALLTGMAMAFARAVGEYGSVIFIAGNMPLISEITPLLIMTKLEQYDYAGATSLGVVMLVTAFLLSLAVNLLQWWSTARHTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I817</accession>
    <name>A0A1W1I817_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2894"/>
    <dbReference type="EnsemblBacteria" id="SLM49061">
        <property type="protein sequence ID" value="SLM49061"/>
        <property type="gene ID" value="NSJP_2894"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2894"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="60"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="323" mass="36187" checksum="2AB8AD7BF71D243C" modified="2017-06-07" version="1">MVGSSMRKAELPEASIPGVYVSVPELMALEHKAAGLTFLPRRTSRSVLSGRHTSRMRGRGLNFEEIRDYLPGDDIRNLDWKVTLRLGKPHVRTYTEERDRPALFVIDQRMPMFFGSRLALKSVAAAQVAALGAWMVLHAGDRVGAMVFNDHEIRHIRPHRSRSRVEALCRAVADMNRALAAGSPVHAEYSQLDRALERALQAAHHDHFVCIVSDFAGMSERTDQLLRELRVHNDLVAVLVFDPLARSAVGDGQLVVTEGTLQVEVNLNERQVREPLESFFAGRLQHVAAMLRRSDVPLLAIDSGEPVIEQIRRLLGRRVPLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I839</accession>
    <name>A0A1W1I839_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3010"/>
    <dbReference type="EnsemblBacteria" id="SLM49177">
        <property type="protein sequence ID" value="SLM49177"/>
        <property type="gene ID" value="NSJP_3010"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3010"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="221" mass="24374" checksum="FE097C5AAEEFABDE" modified="2017-06-07" version="1">MNEPETLPAGVHQEAALLPWYANETLGEEDRQRVARHLESCLECRRELSEWADLGRSIHETYAAQPGPNPALAKAVFSKVAAEIRPAGRDAGRDDQRLTSFDRWLRPLFDVPWVPSLAAVLLAVQSGLLLWVTMPSDRHPISTRSVDSPAARFTVRFHDHATGAQIRDVVVRIHGRIVDGPNAEGTYVLEVKAADAAMSRQILNILRSQNGIIAHADAVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I875</accession>
    <name>A0A1W1I875_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49200">
        <property type="protein sequence ID" value="SLM49200"/>
        <property type="gene ID" value="NSJP_3033"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3033"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="61" mass="6676" checksum="EF561CE52F5E4AAD" modified="2017-06-07" version="1">MGIGGSSGVSWSSLPKGKERIGDPTMPAKKTAMPMATNLRRDDDRKRMVMPPSDMRTHLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I893</accession>
    <name>A0A1W1I893_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thrC</name>
        <name evidence="9" type="ORF">NSJP_3101</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3101"/>
    <dbReference type="EnsemblBacteria" id="SLM49268">
        <property type="protein sequence ID" value="SLM49268"/>
        <property type="gene ID" value="NSJP_3101"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3101"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="8">
        <location>
            <begin position="73"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="415" mass="44861" checksum="10D296A637DF7BA5" modified="2017-06-07" version="1">MAKMKALTCRECGKEYPTKAIHVCEMCFGPLEVKYNYDEIKKTISRQKIEAGPRSMWRYADLLPVEGPAFLGPHAGFTPLVRAKNLGAYLGLDELYIKNDTVNHPTLSFKDRVVAVALTRARELGFETVACASTGNLANSVAAHAASAGMRCYVFIPGDLEAAKVLGNLIYKPNVVEIEGNYDDVNRLCSEIAGEHGWAFVNINIRPYYAEGSKTLAFETVEQLGWRTPDQVVIPMASGSLLTKIWKGLHEMKAIGLIDEVRTRVNGAQAEGCSPISTAFKDGRDFFKPVKPKTIAKSLAIGNPADGYYALKATAESKGAMDMVSDEEVVDGIKLLAQTEGIFAETAGGVTIGVLKKLVKQGTIKKSDVTVAYITGNGLKTQEAVIDAVGRPVRISPSLVAFEKTFKMGKNGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I895</accession>
    <name>A0A1W1I895_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49237">
        <property type="protein sequence ID" value="SLM49237"/>
        <property type="gene ID" value="NSJP_3070"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3070"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="98" mass="11729" checksum="ABBC91D7FF1995BF" modified="2017-06-07" version="1">MLQHHDTDLDRALDRLYLDGAVSIPWDHLYIWFNVDRLSKGAYREIKQRWEKRCTYYGYKKAPALSILQGNNSYPYLLRIIREPFQPGEDLVRLDSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8J1</accession>
    <name>A0A1W1I8J1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49241">
        <property type="protein sequence ID" value="SLM49241"/>
        <property type="gene ID" value="NSJP_3074"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3074"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="764" mass="84860" checksum="FC31456F49D3532B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8K4</accession>
    <name>A0A1W1I8K4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3169"/>
    <dbReference type="EnsemblBacteria" id="SLM49336">
        <property type="protein sequence ID" value="SLM49336"/>
        <property type="gene ID" value="NSJP_3169"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3169"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="345"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="731" mass="81034" checksum="8FA1DD4326E0AC97" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8P4</accession>
    <name>A0A1W1I8P4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49387">
        <property type="protein sequence ID" value="SLM49387"/>
        <property type="gene ID" value="NSJP_3220"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3220"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="230" mass="24746" checksum="2899224CFB85BD10" modified="2017-06-07" version="1">MHIVTCRPAASLGISVLLFAPGCAWQSTYDQAVAEREGVKAELQSVKLEQDRLMEQVKEIEPLTKQARLQAEQANASLRDAVDAAEGARQIGEERQAKLALLIDQLSAQQNSLRQSMRKMKAERPGLQSAVDKYRAQLDEADRLSAAASFPPPPPVHDPIASATVPPPPSLPGPTVTPTSVSSSASVPSSDPLAVPATRPATKRGVEPAEEGFFASMKDWLVSIWRSVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Z0</accession>
    <name>A0A1W1I8Z0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49263">
        <property type="protein sequence ID" value="SLM49263"/>
        <property type="gene ID" value="NSJP_3096"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3096"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="108" mass="11893" checksum="8561AA4B6008958B" modified="2017-06-07" version="1">MPFMRTILLAGFLVLLLNGAGLAEDKSFYSPVIDIEPNTHRILISTLGSVFWIEVPEAGWPHMEKLPISGLVDFVVEMRANGQTPLIKTWKVKSGDSACMVFDGKGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9A9</accession>
    <name>A0A1W1I9A9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bifunctional protein PutA</fullName>
            <ecNumber evidence="8">1.2.1.88</ecNumber>
            <ecNumber evidence="8">1.5.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">putA</name>
        <name evidence="8" type="ORF">NSJP_3408</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="8"/>
    <dbReference type="EC" id="1.5.5.2" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3408"/>
    <dbReference type="EnsemblBacteria" id="SLM49575">
        <property type="protein sequence ID" value="SLM49575"/>
        <property type="gene ID" value="NSJP_3408"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3408"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07124">
        <property type="entry name" value="ALDH_PutA-P5CDH-RocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025703">
        <property type="entry name" value="Bifunct_PutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041514">
        <property type="entry name" value="PutA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005932">
        <property type="entry name" value="RocA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18083">
        <property type="entry name" value="PutA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000197">
        <property type="entry name" value="Bifunct_PutA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PutA_N" evidence="7">
        <location>
            <begin position="11"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Pro_dh" evidence="6">
        <location>
            <begin position="133"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="515"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="746"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000197-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="983" mass="108502" checksum="272A06A88720B976" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9B4</accession>
    <name>A0A1W1I9B4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3450"/>
    <dbReference type="EnsemblBacteria" id="SLM49617">
        <property type="protein sequence ID" value="SLM49617"/>
        <property type="gene ID" value="NSJP_3450"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3450"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06533">
        <property type="entry name" value="Glyco_transf_WecG_TagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00696">
        <property type="entry name" value="wecG_tagA_cpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="252" mass="28288" checksum="12A9BE82D481467C" modified="2017-06-07" version="1">MNREAGVLLGVPIDRKALPALTEESVQAIDGSVSQRIFACANPHSLVVAHDDPDFQRALVQAEFVVADGVGVSLMARVTGLQIGPRIAGLDYFAAVLNALQARGAGRVFFFGSSQRVLDLIAARFVMEFPSLTLCGVLSPPFGEWDEAENSKMIRHINEARPDVLWVGMTAPKQEKWVERNRRQLRVPVIGSIGAVFDFYAGTYQRAPSWVCRMGFEWMYRFMLEPRRMWKRNVVSAPKFIWLALRHHLFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9F1</accession>
    <name>A0A1W1I9F1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49433">
        <property type="protein sequence ID" value="SLM49433"/>
        <property type="gene ID" value="NSJP_3266"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3266"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="165" mass="18613" checksum="49F8F95496C26FB8" modified="2017-06-07" version="1">MERTLQVLNELKRDGILSRYAIGGAMGAMFYIEPLLTFDLDIIVLLPETKGGLLTLAPLYEALRIKGYAEEGECVVIEGVPVQFLPAYNALLEEALQNARTMSYESTSTQVLGAEHLVAICLQTGRTKDRERVRILQEEADLDSEYLGEILRRHQLEGKWKEWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9H5</accession>
    <name>A0A1W1I9H5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49635">
        <property type="protein sequence ID" value="SLM49635"/>
        <property type="gene ID" value="NSJP_3468"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3468"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="238" mass="25313" checksum="9405CF3FEA897813" modified="2017-06-07" version="1">MVVAAVALVIGSACSGAKVTTQKSGSLPRYQVRTLVLLPFETLNTPQIRDAGNRYMSTPRGAQASDISVGVPMSAEPQLHQTMVVPAYAADKITQLFWVRLRNLKGVTILSPAPSSGSKTSTHQAGDLPQVLPEQAAADAAKKVGADAAVVGQVSVYQERVGSRLGANPPASVGFEIKAVAADGHVLWAGNYFERQKPMTEDFSGFIHHGWGFVTVDELTRYGVEELMKVFPFGSTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9K7</accession>
    <name>A0A1W1I9K7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="8">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">tyrS</name>
        <name evidence="10" type="ORF">NSJP_3560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3560"/>
    <dbReference type="EnsemblBacteria" id="SLM49727">
        <property type="protein sequence ID" value="SLM49727"/>
        <property type="gene ID" value="NSJP_3560"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3560"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02007">
        <property type="entry name" value="Tyr_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024108">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF1">
        <property type="entry name" value="PTHR11766:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="230"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM49727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="403" mass="45164" checksum="8FACAB8BA721CCFF" modified="2017-06-07" version="1">MSELVRQIDLILRGTVEVIQQAELESKLSRALAANRPLRIKAGFDPTAPDLHLGHTVLIHKLKHFQDLGHQVIFLIGDFTGMIGDPTGVSETRRALTKDQVRDNATTYERQIFKLLDPKRTTIEFNSRWMSTMSAAELVELASHYRVARMMERDDFHKRYQEQKPISVHEFLYPLVQGYDSVVLKADVELGGTDQKFNLLVGRDLQRDYGQEPQAVITMPLLEGIFGGKKMSKSLGNYVGLEDPPSEMFGKIMSVSDELMIRYYEVLTTEDLASVKTSHPMEAKQSLAQHIVTLYHGQEAGRAAREAFQLKFQEREFPSEPDVRVKVAKDDLGASGTIGLVDLVAMTKLLASKSEARRLVIQGGIEVEGVKQSDANAVLTLNPGSTYRIKVGKRKFALIEVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9L3</accession>
    <name>A0A1W1I9L3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RND-type permease AcrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">acrB</name>
        <name evidence="2" type="ORF">NSJP_3508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3508"/>
    <dbReference type="EnsemblBacteria" id="SLM49675">
        <property type="protein sequence ID" value="SLM49675"/>
        <property type="gene ID" value="NSJP_3508"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3508"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="912"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="938"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="964"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1087" mass="116723" checksum="D16BF2B6EFAE0164" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9N3</accession>
    <name>A0A1W1I9N3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49695">
        <property type="protein sequence ID" value="SLM49695"/>
        <property type="gene ID" value="NSJP_3528"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3528"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021796">
        <property type="entry name" value="DUF3365"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11845">
        <property type="entry name" value="DUF3365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013275124" evidence="1">
        <location>
            <begin position="29"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="245" mass="27146" checksum="753EEE98A4AACF6C" modified="2017-06-07" version="1">MESRCFRGRTMCLVAAAAVTLFGGSAWAANESEIAEHLIELVKIGRGVVSEQMANINDASKADKGFTGDYMGAQVIDRFKKRTKIDLRIPNVVPQANLYLALVEAEKEVINEAQPIINKQGIAFKGFIPAVFARRTGEQFYKKSGVRMKLTGIDYRNPSNRPDDFESEVLRMFSDPRHPKGQTYVRNTMVDGRPVLRMMDPEYAGVTCLNCHGAPKGERDVSGHKKEGWKEGELAGAISVVLPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9U8</accession>
    <name>A0A1W1I9U8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized isomerase</fullName>
            <ecNumber evidence="2">5.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yddE</name>
        <name evidence="2" type="ORF">NSJP_3609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3609"/>
    <dbReference type="EnsemblBacteria" id="SLM49776">
        <property type="protein sequence ID" value="SLM49776"/>
        <property type="gene ID" value="NSJP_3609"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3609"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="310" mass="33615" checksum="8ACBE33806100092" modified="2017-06-07" version="1">MDSGRRSLKFYQADVFTTQPFGGNPVAVFPDAKGLSDDQLQQIAREMNLSETVFVFPPLDPAAVVRLRIFTPTQEIPFAGHPVVGTMFVLTSLGLIATSDPVTRVVQECNIGLFPVDLHVRDGRVLRVVMTQPAPQFLETVDDTEDLYKVANALGIAKHTIADTKWPLVVVSTGLPVLMVPVRTLTAVRSIRPDSSAIIELCRQFGANGLMVFTTMTVEPFATVHARMFAPSIGIMEDPATGSAAGALGSYLVQHGVVDVGPMTEITIEQGYEIERPSRILVQVESDDDMIQTVKVGGQCVMVVEGTLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9W4</accession>
    <name>A0A1W1I9W4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RibD_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3618"/>
    <dbReference type="EnsemblBacteria" id="SLM49785">
        <property type="protein sequence ID" value="SLM49785"/>
        <property type="gene ID" value="NSJP_3618"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3618"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="176" mass="19926" checksum="1431D4F485572F22" modified="2017-06-07" version="1">MAKLVFGMNQSLDGYVDHMAFAPGPTLFRHFIEEAQGQAGSVYGRHMYEIMRYWDDDHPEWSADEHAFAAAWRNQPKWVVSRSLKSVGPNARLVGDDIEGAIRKLKVECDGEIEVAGPNLARSLTELGLIDEYRIYLHPVVLGHGKPYFAGPRPRLRLMTNDRMGEDVIRLTYVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA18</accession>
    <name>A0A1W1IA18_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type multidrug transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49887">
        <property type="protein sequence ID" value="SLM49887"/>
        <property type="gene ID" value="NSJP_3720"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3720"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="380" mass="42139" checksum="584A720A1103753E" modified="2017-06-07" version="1">MTAHNLFSPARFWAMVVKEFVQMRRDRLTFGMMIGIPLIQLILFGLAINADPKHLPTAVLLADRGPQGRSLLEAIRHSNYFEFVRELRTEAEARAAIARGDVQFVVSIPENFTRDLWRGDRPAVLVEADATDPAATGNAIGSLRMLVNSAFQHDLKGPLAFLARQDDPVELRVHAQYNPEAVTHYNIVPGLMGVVLTMTMVVITGLAITRERERGTMENLLSMPTRPFEVMIGKIIPYILVGYVQVGLILLAARFLFGVPMEGNLVLLLLAALVFIAANLAVGITFSTIAQNQLQAMQMSFFFFLPSLLLSGFMFPFRGMPAWAQAIGEVLPLTHFLRIVRGILLKGNGVDEVLLQLWQVALFAAVALTIGVTRFRQTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA22</accession>
    <name>A0A1W1IA22_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3446"/>
    <dbReference type="EnsemblBacteria" id="SLM49613">
        <property type="protein sequence ID" value="SLM49613"/>
        <property type="gene ID" value="NSJP_3446"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3446"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012686958" evidence="2">
        <location>
            <begin position="19"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="405"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="643"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="796" mass="88292" checksum="1F7EB814F4FDD525" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA30</accession>
    <name>A0A1W1IA30_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49845">
        <property type="protein sequence ID" value="SLM49845"/>
        <property type="gene ID" value="NSJP_3678"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3678"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="73" mass="8206" checksum="8A9CBF973A7BE194" modified="2017-06-07" version="1">MDTPVVVDSARSLLKTIRSLLEMVWQDLQVERANRVISSNTISQAMAGHDSSGAMARQESRKSNSFKYHPADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA94</accession>
    <name>A0A1W1IA94_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49915">
        <property type="protein sequence ID" value="SLM49915"/>
        <property type="gene ID" value="NSJP_3748"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3748"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="68" mass="7708" checksum="4F03DB3B92864794" modified="2017-06-07" version="1">MSLLFTPVQSIKQRLARRRQMRIALQMLAVSGVLRPGDSELRYTVPLTRKRLGSAPYSRSMSHVPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAF3</accession>
    <name>A0A1W1IAF3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3805"/>
    <dbReference type="EnsemblBacteria" id="SLM49972">
        <property type="protein sequence ID" value="SLM49972"/>
        <property type="gene ID" value="NSJP_3805"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3805"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="407" mass="46563" checksum="7EC5012CEA7F90D2" modified="2017-06-07" version="1">MITRAFLPRKIAAGLALCLVALVLLGVTIETGLAVVQINTRSNLRFIPQLGTTYIPNAFYRHTKEGYSEGYFNSHGFRDYERTYGKPAGTFRILVFGDSYVEALQVPLADSFSAILERKLNEHARSESFEVLALGQSGFGTADAYMRYLNFGAKYDPDLVVLAFTTINDFHDNSRYLNQDNISFYFKFDLNKNLVLDRSLFEEYEHNLTLTKRVFQALARHSYFVSLVSERAFLLREQLRHMNFEGRTSGSDVRTNTIQPDEFSDLNIYRPEMSSRWQEAVAITKGIIHEFKASVEGDGGRFLLVTLSNAEQVHPHKAKELTDKYGDLFDFDQPDRILDELSQQEGIMMLKLMPIFRDYHHKTGVFLHGFGSSQGGHWNHEGHRLAAEELFAFLHNNDLVPLSKSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAI6</accession>
    <name>A0A1W1IAI6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="8">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glycyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="8">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">glyS</name>
        <name evidence="9" type="ORF">NSJP_3867</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3867"/>
    <dbReference type="EnsemblBacteria" id="SLM50034">
        <property type="protein sequence ID" value="SLM50034"/>
        <property type="gene ID" value="NSJP_3867"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3867"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00255">
        <property type="entry name" value="Gly_tRNA_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015944">
        <property type="entry name" value="Gly-tRNA-synth_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006194">
        <property type="entry name" value="Gly-tRNA-synth_heterodimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30075">
        <property type="entry name" value="PTHR30075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02092">
        <property type="entry name" value="tRNA_synt_2f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01045">
        <property type="entry name" value="TRNASYNTHGB"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00211">
        <property type="entry name" value="glyS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50861">
        <property type="entry name" value="AA_TRNA_LIGASE_II_GLYAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM50034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="725" mass="79403" checksum="B7462B18BB4A98B2" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAM5</accession>
    <name>A0A1W1IAM5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative RNA polymerase sigma factor FecI (Sigma-19)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3940"/>
    <dbReference type="EnsemblBacteria" id="SLM50107">
        <property type="protein sequence ID" value="SLM50107"/>
        <property type="gene ID" value="NSJP_3940"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3940"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="119"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="182" mass="20793" checksum="904ECF25B18816CA" modified="2017-06-07" version="1">MSDQDLWCLTPMPTSPLGMAFQQYAQELQRFLQRRLGCPEAAADLLQETFLRVAQLPASTQPDNPRAFLFRIASNLAIDELRRNQVRRPFQEPLEEAEHVPSATPSCEQAIFDKQRMTLLQSALEQLSPRCRTIFMLRRVQGHSYDEIAHRLGVSERIVAKEINRALAHCQQALLAALKEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAN4</accession>
    <name>A0A1W1IAN4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Multidrug resistance protein A (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3883</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3883"/>
    <dbReference type="EnsemblBacteria" id="SLM50050">
        <property type="protein sequence ID" value="SLM50050"/>
        <property type="gene ID" value="NSJP_3883"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3883"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043602">
        <property type="entry name" value="CusB_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00529">
        <property type="entry name" value="CusB_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="CusB_dom_1" evidence="5">
        <location>
            <begin position="32"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="6">
        <location>
            <begin position="57"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="402"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM50050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="499" mass="54024" checksum="2B616F7CC600B405" modified="2017-06-07" version="1">MTQDSGTDDVSLRRQRNRRLLAVTAALVLAGAAYGTYWWTVSSHWVQTDNAYVTGNLVPVAAQATGIITQVRFEETQFVNRGDVLVRLDEHEAYAALGRARGRLGETVRRINSLFLTQRQVDEKLAARRARLEVIRHDAERYRKASPTGAVSKQTLQNALDHLQALEADVRETEAEYDALDAQIGGTTVMEHPAVELAKHEFIEAHLEYARQRILAPVSGYVAKRKAQVGDRVKPGANLMTIVPLDHLWVEANLRETELGDIRPGQPAEIRVDLYGDKHTFHGTVEGLVPGTGSPFALLPPDNSTGNFIHIIERVPVRIALAADEIREHPVRPGLSTVTKIRVGEPGQSVWSSLAKADTDEYQTDVYGDELTSAESVAQGVIAGNVRTVGSNSGPTAAIARATEDEALSAQAPTTRSDLGMTDRSGEHPLRRNAGEDSGTVIPSTVPPRSPDLGEAQRPLSPSIGAGSDRFGQQASPPAFSRPAGVPERAGSHMKSTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAW1</accession>
    <name>A0A1W1IAW1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Acyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_4020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4020"/>
    <dbReference type="EnsemblBacteria" id="SLM50187">
        <property type="protein sequence ID" value="SLM50187"/>
        <property type="gene ID" value="NSJP_4020"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4020"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="24"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="358" mass="40287" checksum="5E34C18A05242210" modified="2017-06-07" version="1">MTIHSTSQKQADDSSSIFNSSYLPGLDGLRAVAILTVIVYHFGFGQVPGDLGVELFFVLSGFLITRQLLREFRQSGAVDLGRFHHRRLLRIFPAYYVYLAFAFIEECARGYCWTPGLLASGIGHVVNYYNAFNGHPNTVIAHAWALSLQEQFYILWPLALIVLVRRGGRWVIAGLTAGIFVVVLWRCALIGTIGIVPAYLYNALDTRFDSLALGCVLAALTEFPEAAVRVQALSKWPLMPVGTLAILLMSRLYGSDSYHYSIGFTVDTFLLTLFVMQIVLQHGHWMWTWLDHPVSRYVGKVSYSLYLWHLIGFGVANRMTQFQPVLQLVVALLVGMGLASASYWLIERPFLKIREKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB00</accession>
    <name>A0A1W1IB00_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General secretion pathway protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gspG</name>
        <name evidence="2" type="ORF">NSJP_4009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4009"/>
    <dbReference type="EnsemblBacteria" id="SLM50176">
        <property type="protein sequence ID" value="SLM50176"/>
        <property type="gene ID" value="NSJP_4009"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4009"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="138" mass="15211" checksum="8CDDB1FF2A180E60" modified="2017-06-07" version="1">MTSRLMEPNIAIGNRTVRMPNGFTLIELLIVVSIVGILATMAIPTYQASLIKAREAALRQDLFTLRDVLDQHRADQGKFPASLQILVGTGYLRTVPKDPFTNSETTWQEITGGVEEGVIDVFSGSDFVGTNGVPYNRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB49</accession>
    <name>A0A1W1IB49_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_4055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4055"/>
    <dbReference type="EnsemblBacteria" id="SLM50222">
        <property type="protein sequence ID" value="SLM50222"/>
        <property type="gene ID" value="NSJP_4055"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4055"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="310" mass="35614" checksum="0E05526F99940FE0" modified="2017-06-07" version="1">MNNTVYYDPMFSDDRRRELLFEGQLFVYSPRPSSLAFVNFARKLIEEAFAPLNPELAQYEMSVEQYAEVLIKLKPGFIHHPESKRLIHNLFREMGCDLEKTYFDVPKMRSSTSDNYLTTGIAYAWHPHRDTWYSAPSCQINWWIPIYGIQADNAMAFHPRYWNRPVKNSSKGYNYYLWNQQNRGAHVARFLKEDPRPLPKSTEALDLDPQIRLIVPAGGIIMFSGAQMHSSVPNTSGKTRFSIDFRIVHEDDVRKKQGAPSVDEECTGTTMRDYLRGTDFSHIPDSLIALYDDGSGIEGELVFNPSEPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB79</accession>
    <name>A0A1W1IB79_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_4068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50235">
        <property type="protein sequence ID" value="SLM50235"/>
        <property type="gene ID" value="NSJP_4068"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4068"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="518" mass="54566" checksum="64FD3A8B1B6A8F92" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBM5</accession>
    <name>A0A1W1IBM5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC</fullName>
            <ecNumber evidence="5">3.1.3.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kdsC</name>
        <name evidence="5" type="ORF">NSJP_4122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KdsC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.45" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4122"/>
    <dbReference type="EnsemblBacteria" id="SLM50289">
        <property type="protein sequence ID" value="SLM50289"/>
        <property type="gene ID" value="NSJP_4122"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4122"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019143">
        <property type="term" value="F:3-deoxy-manno-octulosonate-8-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010023">
        <property type="entry name" value="KdsC_fam"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006118">
        <property type="entry name" value="KDO8-P_Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01138">
        <property type="entry name" value="C1.6.2:_Deoxy-d-mannose-octulo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01670">
        <property type="entry name" value="KdsC-phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006118-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM50289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="183" mass="19567" checksum="208FA04C688BCE02" modified="2017-06-07" version="1">MATSRAAAHGGKKAAGKRLAGKLKGIRLFATDVDGVLTDGGMYYAESGDEWKKFNTRDGMGIKLLQRAGLVTAIVTQERTKLVARRAEKLAIPEVHQGVMDKLVLVREMAARHGLTMEQVAYIGDDINDLATLKAAGFSATPLDGVRPVIAAVDYVCRKKGGEGAVREVIDLILDARSGFVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZR8</accession>
    <name>A0A1W1HZR8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46241">
        <property type="protein sequence ID" value="SLM46241"/>
        <property type="gene ID" value="NSJP_0069"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0069"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012122246" evidence="1">
        <location>
            <begin position="19"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="255" mass="27743" checksum="86FC8BC980E28EE6" modified="2017-06-07" version="1">MNLSKICVAILVSTMGQAAVLYAPADAIQIETQSEKEANLKGQITGGLFNRWTFDQQQPSESPADFSQLTFGGESTGTWTIEADPESPSPPNMLKAVSSCKQETCYRMLVASKLQYEYPDVSVRLRFPAEGGTGRGGIIIGLKDASQFYAAIIDLSAKRLEVVRMVDGNVTVLGQTAIVPKATEWHSLRIQRNTIISKDFLETFFDGAQVLSIQDHSLGFGEVGLVVLGDSSLYFDSLHAVPLFSQRPLSNPAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I043</accession>
    <name>A0A1W1I043_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0165"/>
    <dbReference type="EnsemblBacteria" id="SLM46337">
        <property type="protein sequence ID" value="SLM46337"/>
        <property type="gene ID" value="NSJP_0165"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0165"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="PTHR23264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="317" mass="34668" checksum="061D165CFC05F2FC" modified="2017-06-07" version="1">MPRELNIIQTPTSGGSDACTYMWACAICDENESCQKDKEGHSRWLVAKRMERIEYKVLIMSNKGGVGKSTCTTNLAVSLALKGWHVGICDMDIHGPNIPKMVGAEGQKLKISTSGGIIPFQAYNLKIASMSFLLQNPDDPIIWRDAYKYEFINQLLGGVEWQDLNFLLIDLPPGTGNESVTTIDLLGQVSGAVIITTPQEVALLDSRKSVTFCKDSEVPIVGIVENMSGLECPHCHHHIEVFRKGGGEASAHDMGVPFLGRIPLDPDVVTQSDAGEPFAMFYSDTPTAEAYHEIANKVEAFCKKSGSLVNVAPRHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0R6</accession>
    <name>A0A1W1I0R6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46595">
        <property type="protein sequence ID" value="SLM46595"/>
        <property type="gene ID" value="NSJP_0423"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0423"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="494" mass="54863" checksum="80E98B5C8D492BB6" modified="2017-06-07" version="1">MTTSNLLYRCSAIRDALVDAGLFAASAGTSAAGDADTALNSWRIGTVPFLLSADQIGFFRRLGPHLLSFYRALNRLYAESARGLQPSWIAEALDRGKPEGLVSYSRMKRFRDLLPAVIRPDVIPTADGMVITELDSVPGGIGLTACLSRAYADNGFLNPEDPSSPATMRLVGGRDGMIDGFGAMLTHLRGSREGCTAVVVSDEAKDYRPEMTWMTARLSERGIETRCVQPRDVRFTEGTLRIVDGDREQPIALMYRFFELFDLPNIPKSELIQYAAKKDWVTVTPPYKPALEEKSAFALLHHPMLRSFWRRELREDTWLHLTTVMPRTWLLDPAPVPPQATIPGLSIGDRAITNWRDLLSATQKERHFVIKPSGFSELAWGSRGVSIGHDLPQSEWATAIDEALAAFPRTPYILQEFHKGRQYHLEYYDPASGEMRQMAGRARLSPYYFVAGEKVELAGILATVCPADKKIIHGMKDAILVPCAVAPEGQPRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0U4</accession>
    <name>A0A1W1I0U4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0439"/>
    <dbReference type="EnsemblBacteria" id="SLM46611">
        <property type="protein sequence ID" value="SLM46611"/>
        <property type="gene ID" value="NSJP_0439"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0439"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021796">
        <property type="entry name" value="DUF3365"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11845">
        <property type="entry name" value="DUF3365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013343131" evidence="1">
        <location>
            <begin position="29"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="197" mass="21720" checksum="FACFAEFC3E97B50C" modified="2017-06-07" version="1">MYRLRYPRHVAAVTFVALWGWSASTAFSAKEAAPSPGIAPEKVASYVHAVLQADRTIYTNQVVNRMQEKGVVSAAEHWEQDNALPLPAQFLQHSGRLVAESGQGIRYRLIGLSPIYQRNAPATDFERKALESLNRSSDAPVTGIVTSGRKQYFQAIYPDRAVSSACVSCHNRHPLSPKRDFKLNDVMGGIAITIPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I131</accession>
    <name>A0A1W1I131_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Rhomboid serine protease</fullName>
            <ecNumber evidence="7">3.4.21.105</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_0519</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0519"/>
    <dbReference type="EnsemblBacteria" id="SLM46691">
        <property type="protein sequence ID" value="SLM46691"/>
        <property type="gene ID" value="NSJP_0519"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0519"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="68"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="232" mass="24495" checksum="6F8EBD9FDCB260F3" modified="2017-06-07" version="1">MIPLHDDNPTDGTPVVTVALIVSCVLVFLYQSSLPGEPGERFVFEFGAIPAVVFGTAQIPAVVIPPYATLVTSMFLHGGWMHLIGNMLYLWIFGNNIEDVMGHGRFIVFYLTCGILAALSHALTDPSSTVPMVGASGAISGVLGAYVLLFPRAHVLVFIPGIGTTRVAAGVVLGMWFATQLLSGGMSAGSPGGGVAFFAHIGGFVAGMMLIGLFKRADVPFFAPARLRRWDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I148</accession>
    <name>A0A1W1I148_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46563">
        <property type="protein sequence ID" value="SLM46563"/>
        <property type="gene ID" value="NSJP_0391"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0391"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="172" mass="18523" checksum="6EA3BDFCF8B61390" modified="2017-06-07" version="1">MEHVKGISAFAMVVVVCGAVALGTAGVSFADGKGTGAHRHYKGEVVEKAGNLAIKDETGSTYSLSENEAHRQGREFKVGDKVEFTVNENNALIDVHLVGEKGKHKHVTGKLIHVGLMKKEIKLQTAEGEKTFPLLLQETKTKALAEGTEVTVELNEAGTVIDLHEGKHKESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1D0</accession>
    <name>A0A1W1I1D0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46810">
        <property type="protein sequence ID" value="SLM46810"/>
        <property type="gene ID" value="NSJP_0638"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0638"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="55" mass="6069" checksum="83A5803326876450" modified="2017-06-07" version="1">MKELRTKSISKFCLPKWKGGVSSVTLHRPADSTLTSDIAQAKIMNLTRVGPLNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1D1</accession>
    <name>A0A1W1I1D1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46797">
        <property type="protein sequence ID" value="SLM46797"/>
        <property type="gene ID" value="NSJP_0625"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0625"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="68" mass="7399" checksum="B39AB70BFE3B90F5" modified="2017-06-07" version="1">MKRLASEIYDAVKLGKLLEPFTAQDVKKACPGWAVATYGTFLPKHRVGNPGGNTALFRQVGSALYECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1E4</accession>
    <name>A0A1W1I1E4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0517"/>
    <dbReference type="EnsemblBacteria" id="SLM46689">
        <property type="protein sequence ID" value="SLM46689"/>
        <property type="gene ID" value="NSJP_0517"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0517"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="349" mass="39577" checksum="3D0B21528A115E23" modified="2017-06-07" version="1">MPVKATTSRSRTVLSNDEMMRQVRTILESPEDDLQAGLVKELLSGVLRLHDSHLEALDLKIVNRTIKELRHAFRVFHDYRDRRKISIFGSARTANDDPNYGLAVEFAKRIVREGFMVITGGADGIMRAAQEGAGRENSFGVNIMLPFEQGPNATIADDPKLVTFKYFFTRKLIFQKEANAIALFPGGFGTHDEGFEILTLAQTGKSDPQPIVCLQAPGCDYWDEWQGFITRQLLSRQLISPEDLCLYKIVTSAEAAVEEIKTFYRRFHSIRYVGRQLVIRMSSPLSQEQVEALHDQFGDLLSEGTFESHGHLPEELDEPELTGLPRLMFMSNRKSASRLRQLINHLNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1F1</accession>
    <name>A0A1W1I1F1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46811">
        <property type="protein sequence ID" value="SLM46811"/>
        <property type="gene ID" value="NSJP_0639"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0639"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="149" mass="17055" checksum="3E320181E6C379B8" modified="2017-06-07" version="1">MDIFSFKLGLLSFWGLWFASACSTNLCDGFRTWGIFHRTWPFASGNFKNLTDAIQVWSPPWWLSWLLFSAVVSWQLLAALLFGWAVLSSLMKGSMDLAIINSAFTVALGLWVAFMLVDEILKQYDTEHNHILFFMAQLLSFMPIYVLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1H4</accession>
    <name>A0A1W1I1H4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 3-hydroxybutyryl-CoA dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.157</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mmgB</name>
        <name evidence="6" type="ORF">NSJP_0547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.157" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0547"/>
    <dbReference type="EnsemblBacteria" id="SLM46719">
        <property type="protein sequence ID" value="SLM46719"/>
        <property type="gene ID" value="NSJP_0547"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0547"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008691">
        <property type="term" value="F:3-hydroxybutyryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="5">
        <location>
            <begin position="8"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="4">
        <location>
            <begin position="189"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="299" mass="32015" checksum="D64A00A4E227BA3D" modified="2017-06-07" version="1">MTLEDIKTIGIVGAGQMGRGIAQVCATAGYRVLLVDVTEASLTEALAKIRAGLERASERGSLTSYRAGEALALIRPTVELDRLHAVQLVIEAIPEDLALKERLFAELNRICRPRAILASNTSSISITKLGTAAGRPADVVGLHFMNPAPVMHLLEVVRGLETSETTLNLALGLAKRLGKTPVLAKDVPGFIVNRILIPMINEAIFALENGVASAEDIDLAMVTGANHPVGPLALADRIGLDTVLSICDVLHRGLGDAKFRPCPLLRRYVEAGWLGRKTGRGFFLYEASGERREALSGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1L7</accession>
    <name>A0A1W1I1L7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Type IV pilus assembly protein PilW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0728"/>
    <dbReference type="EnsemblBacteria" id="SLM46900">
        <property type="protein sequence ID" value="SLM46900"/>
        <property type="gene ID" value="NSJP_0728"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0728"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043683">
        <property type="term" value="P:type IV pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032092">
        <property type="entry name" value="PilW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16074">
        <property type="entry name" value="PilW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="374" mass="39117" checksum="2B22B975E4EBB380" modified="2017-06-07" version="1">MDTERRMYSQHGITLVELMIALAVTSIIVTAGFTVLTTTDKSTKANEQAAGTQQNARLAMELIARDIKLAGFRMPLSPNVPVGGTAGNCASGGTSLAIRPVDKISTPSALPNDDGPDTLSLIVPRTNPGWTLSQAVPVAPASSFTAITLNGTAVSEMQTEGMVNGTGAYVSVGGVLTAQVSTSSGSAVNFSSGFNLPVTFPAGTQVYLLQCITYSIGQTSTACGTSSPCLLRTVDTGTAAPSVTNIVDGVEDIQFALACDGCNGAIKTGVPDGVIDDWNANNTFDVGDWQTNRVWSPLTFDPATIRMVQVNVVARQSVRDQGLGEAQQAGVLTAGPLTISDHIHSADPGYVASTYQQFRRRQLTRTVDARNVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1W4</accession>
    <name>A0A1W1I1W4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_0810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0810"/>
    <dbReference type="EnsemblBacteria" id="SLM46982">
        <property type="protein sequence ID" value="SLM46982"/>
        <property type="gene ID" value="NSJP_0810"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0810"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010706013" description="Plastocyanin-like domain-containing protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="199"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1593"/>
            <end position="1612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1612" mass="179177" checksum="D4D560CF647C3679" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I271</accession>
    <name>A0A1W1I271_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Protease QmcA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">qmcA</name>
        <name evidence="3" type="ORF">NSJP_0920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0920"/>
    <dbReference type="EnsemblBacteria" id="SLM47092">
        <property type="protein sequence ID" value="SLM47092"/>
        <property type="gene ID" value="NSJP_0920"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0920"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="Band_7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="21"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="313" mass="34150" checksum="8B8C5B310FAECAC7" modified="2017-06-07" version="1">MASGTLVVLILALLVLYVIAKTAVVVPQQSAYVVERLGKYSATLNAGFHILLPFIDTIRYRHSLKEVAIDIPEQVCITRDNVQVSVDGVLYLKVLNPERASYGISDYHFALSQLAQTTLRSEIGKIELDRTFEERTNINIQVVNELDKASEPWGVKVLRYEIKNITPPKDVLNAMEKQMRAEREKRALILTSEGERDAAINQAEGEKQQVIKASEARKQQQINEAEGAASAILAIAQATAEGLHKVADTIRVPGGQEAVQLRVAEQYIAKFGELAKAGTTLVLPASVSDVGSMIALAMSAVRQTGQTSPSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I289</accession>
    <name>A0A1W1I289_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Glutathione transferase FosA</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46979">
        <property type="protein sequence ID" value="SLM46979"/>
        <property type="gene ID" value="NSJP_0807"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0807"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="145" mass="16076" checksum="78530A13C8E57FD0" modified="2017-06-07" version="1">MDVPAHRGLRHVALRVTNLKRSRAFYEQVLGMSVVWEPDADNVYFSSGADNLALHQISPGELQAYAAATRQLLDHLGVIVESPQAVDRMYAAVAPKIVSLGGAIAKEPKQHRDGSYSFYFSDPDGNVIQALYEPTISRLRWVSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2E0</accession>
    <name>A0A1W1I2E0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_0980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0980"/>
    <dbReference type="EnsemblBacteria" id="SLM47152">
        <property type="protein sequence ID" value="SLM47152"/>
        <property type="gene ID" value="NSJP_0980"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0980"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfate_transp" evidence="6">
        <location>
            <begin position="15"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="523" mass="56020" checksum="5113D54AC52B31BE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2F2</accession>
    <name>A0A1W1I2F2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">dnaA</name>
        <name evidence="13" type="ORF">NSJP_1003</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1003"/>
    <dbReference type="EnsemblBacteria" id="SLM47175">
        <property type="protein sequence ID" value="SLM47175"/>
        <property type="gene ID" value="NSJP_1003"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1003"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="150"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="12">
        <location>
            <begin position="360"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="158"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM47175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="453" mass="51174" checksum="223DD6D1EFCFA59B" modified="2017-06-07" version="1">MGDIAGIMTVASVWQEALAYIQGKVPKQVYDTWFTPVHLERIEDSTAQIAVPNKFFGDWLSQHYGPLLEEAVSTARGGGETAVSFVVFNRLAAKPIDPTVIEQARAVAGSKPKRGIQLNPKYTFKNFVVGAGNQFAHAACMAVAEQPAKAYNPLFIYGGVGLGKTHLLNAIANHVAERTDLRIAYLTTEQFTNEVINSIRYDKMMDLRKRYRHIDMLMIDDIQFLAGKERTQEEFFHTFNSLYEAHKQIVLSSDRFPKDMPDIEERLRSRFEWGLIADLQPPDVETRIAILRKKSEDEGVRLPEDVIQFLSTTMKSNIRELEGSLVRLGAYASLTGQVITLDMARNVLRDLIGDKKKIVSLEDIQEVVSTWFHVRIADLKSRRRSKTLVHPRQIAMYLCRELTDASYPEIGRHFGGKDHTTIIHACRQIGKARDTDSSLQATLDGLKDKILRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2L2</accession>
    <name>A0A1W1I2L2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47232">
        <property type="protein sequence ID" value="SLM47232"/>
        <property type="gene ID" value="NSJP_1060"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1060"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="93" mass="10028" checksum="AC2EF732AF54FF07" modified="2017-06-07" version="1">MARSVPPSGQSNGNPSPPAEESTVSEVELLRVQVSRKGSQVDAQWAIHPQLKQDLLPNEWQEVTDLMGKVAGIVGHRFSQILSQADSDPPSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2N2</accession>
    <name>A0A1W1I2N2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1059"/>
    <dbReference type="EnsemblBacteria" id="SLM47231">
        <property type="protein sequence ID" value="SLM47231"/>
        <property type="gene ID" value="NSJP_1059"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1059"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023984">
        <property type="entry name" value="rSAM_ocin_1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00324">
        <property type="entry name" value="bacteriocin_maturation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="71"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="617" mass="70358" checksum="18D800B531A93BA7" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Q1</accession>
    <name>A0A1W1I2Q1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47251">
        <property type="protein sequence ID" value="SLM47251"/>
        <property type="gene ID" value="NSJP_1079"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1079"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="98" mass="11115" checksum="D5E2210F040D895F" modified="2017-06-07" version="1">MSTKAMEAEEAILNMLQRYEVLAMEDLIVGRPDFTWGQLFLAVDRLSRTNVIALSRFGLSYHLRLMPCEDQLATPQGQKEPAARLTSKAEAYRAEIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2T0</accession>
    <name>A0A1W1I2T0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1132"/>
    <dbReference type="EnsemblBacteria" id="SLM47304">
        <property type="protein sequence ID" value="SLM47304"/>
        <property type="gene ID" value="NSJP_1132"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1132"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009599">
        <property type="entry name" value="DUF1207"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06727">
        <property type="entry name" value="DUF1207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="367" mass="40874" checksum="06449ED913D50914" modified="2017-06-07" version="1">MGRKGRSYWLVFGVGFFCLLWLAENRAFASDEYIAGYASAMLEHEYRVTDAVVDVVNGEIVVTARTLGNVDRGKVEASLRRISGVTRVTLRTGDPASVPPSPEGAHVTIPESQSKWLPRGLLFSPLHADPRWPHFSASYRHYTQGLDLSGVAATSFGETFAIYRNRSFFGGEWDIGIQAGVFSIFNVDSASIDLVNADYRVGVLSSYRNGRFSLMARIQHQSSHLGDEFLLGNPGVTRINLSYEAVDLKLSYEFFDWLRLYGGGGVLVHRDPDDLGLATTQWGVELVSPRTFLDGLVRPVAYGDFQCNQMTNWGVGQSIMAGLQFENARIGDRRIQVLGEYYAGPSPDGQFYREYVSWYGVGVHLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2U5</accession>
    <name>A0A1W1I2U5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Osmotically inducible, stress-inducible membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">osmC</name>
        <name evidence="1" type="ORF">NSJP_1027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1027"/>
    <dbReference type="EnsemblBacteria" id="SLM47199">
        <property type="protein sequence ID" value="SLM47199"/>
        <property type="gene ID" value="NSJP_1027"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1027"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019904">
        <property type="entry name" value="Peroxiredoxin_OsmC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03562">
        <property type="entry name" value="osmo_induc_OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="141" mass="14643" checksum="21B2D153FA0BB4BF" modified="2017-06-07" version="1">MKRSASAVWQGDLKAGKGTVSTESGVLSQAQYSFGTRFESGKGTNPEELIAAAHAGCFTMALSAQLGNAGFAPEKLETTATVHFEKLDAGWTVTKIHLDVKGTVPKADAAAWEKAATAAKTGCPISRLLNTTITMDAKLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2V0</accession>
    <name>A0A1W1I2V0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative terminal oxidase subunit II</fullName>
            <ecNumber evidence="8">1.10.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">qxtB</name>
        <name evidence="8" type="ORF">NSJP_1152</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.-" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1152"/>
    <dbReference type="EnsemblBacteria" id="SLM47324">
        <property type="protein sequence ID" value="SLM47324"/>
        <property type="gene ID" value="NSJP_1152"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1152"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="335" mass="36120" checksum="286B6986F2E7DAFC" modified="2017-06-07" version="1">MLELLLGAALVGSLTFYLLLGGADFGAGIWSLFTFHHRGKAQRALIDQAIGPIWEANHVWLIVAVTILFTAFPEAYTVIVVGLHIPLSLMLVGIVLRGTTFALRTHDVASRQSGSGPSELWWYLFAGSSLLTPVLLGMSLGAIASGRLRDRTGESFYETFVAPWLSSFPFSVGLLTALLVAYLAATYLIVESREAGLKHLFRRRAVAAWAVVGVAALVALYLSRTGAPEIYRGLTGTGMGLATLALTATGQAVALLSLLRGRDRMARLGAAAVSVLMLWGWALSQFPFLVEPDVTIYQSAEPATLRILLVSLAAGSVLLIPLLRYLYMIFKSRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I333</accession>
    <name>A0A1W1I333_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1245"/>
    <dbReference type="EnsemblBacteria" id="SLM47417">
        <property type="protein sequence ID" value="SLM47417"/>
        <property type="gene ID" value="NSJP_1245"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1245"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="298" mass="33394" checksum="F8709C7A50325F07" modified="2017-06-07" version="1">MIMTNLVSEQLAALSHLFSSGVVREMARKGRSSIFARLANESGLQQSLPSSHLVRDLFDIAFSLLKREGYRHEYIYKAALTHNILLGTHRLRTASMLTEFRIGECKADVAILNGTSTVYEIKSERDSLSRLERQVAAYSKVFATVYVIAAEGHVPSILKSVPPYVGVMRLNNRYQIQKVREALDQPERTNPDAIFDSIRTQEARAILLAQGAKLPVVPNTELNGALRELFVKLKPHEAHDGMVRVLKKTRTLLRLSDLVAQLPYSLQTAALSVPLRKLDHVRLVSAVNTRLKDAMVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I346</accession>
    <name>A0A1W1I346_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47428">
        <property type="protein sequence ID" value="SLM47428"/>
        <property type="gene ID" value="NSJP_1256"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1256"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1461"/>
            <end position="1480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1480" mass="163384" checksum="E4EE851871F7C878" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I386</accession>
    <name>A0A1W1I386_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Deoxyribodipyrimidine photo-lyase</fullName>
            <ecNumber evidence="7">4.1.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">phrA</name>
        <name evidence="7" type="ORF">NSJP_1282</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA photolyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.3" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47454">
        <property type="protein sequence ID" value="SLM47454"/>
        <property type="gene ID" value="NSJP_1282"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1282"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901363">
        <property type="term" value="F:heterocyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097159">
        <property type="term" value="F:organic cyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="PTHR11455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="481" mass="54703" checksum="162024D61BAD6C7E" modified="2017-06-07" version="1">MRGVVWFRRDLRLADQPALTAACEECDEIIPLFVFDEPLLQSRAFGDACVNFMLGCLDDLAERLASLGVPLRWRRGDPAVEVPSAVLEWKADAVYWNRDYEPAAIFRDRTVEVELMQRGVQVRSFKDHVIFEADEVQSATGGPLQRYGAYRARWWTKWQAAKPAILPVPKTLSSRGAQCPVSCPVIPSPDILGYDRVPVRIEPGERNAVKRLRRFVKGPLHRYAAGRNRPAIDGSSMLSPHFRFGTLSARTAVRAALDSLTGSGPVSRADVVTWIDELIWREFFQQVLAAFPHVAEGPFRETSAPPARQPGQERDRLYRAWCEGRTGYPIVDAGMRQLNETGWMHNRVRMITASFMIKDLRLDWRSGERYFMRQLIDADVAANNGNWQWCASTGTDAMRGYRIFNPALQSKKFDSDGVYIRTYVPELDRVSSAHIHEPHLMTLEAQRRAGCRIGYDYPAPIVDHGQARREYLDLAKRRVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I393</accession>
    <name>A0A1W1I393_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1259"/>
    <dbReference type="EnsemblBacteria" id="SLM47431">
        <property type="protein sequence ID" value="SLM47431"/>
        <property type="gene ID" value="NSJP_1259"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1259"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="791" mass="88960" checksum="44B20295F858EC4F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3B5</accession>
    <name>A0A1W1I3B5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47492">
        <property type="protein sequence ID" value="SLM47492"/>
        <property type="gene ID" value="NSJP_1320"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1320"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="134" mass="14380" checksum="468E656380908233" modified="2017-06-07" version="1">MPLKKGDLIDERKRHPDSCGLVVKVMDGGAGFEKIICCDHELTDEDVVPEIRHSAGRKRGVLPLAVVLDEKKLYPDSCGLRVMIMDGGAGFKEIRCCGHSLTMSSMRELKYGALRGAGPGEESDAQPNAPAGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3E5</accession>
    <name>A0A1W1I3E5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Gamma-glutamyl-gamma-aminobutyrate hydrolase</fullName>
            <ecNumber evidence="1">3.5.1.94</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.94" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1323"/>
    <dbReference type="EnsemblBacteria" id="SLM47495">
        <property type="protein sequence ID" value="SLM47495"/>
        <property type="gene ID" value="NSJP_1323"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1323"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033969">
        <property type="term" value="F:gamma-glutamyl-gamma-aminobutyrate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="248" mass="27798" checksum="19D8307E8C940156" modified="2017-06-07" version="1">MKPFIGVTPDFNAGDRKEWGGKEPTYFLRARYVRAIEELGGIPIVLPLASDREARRRLFTNIHGLLLTGSGPDLPPNLYGERQQYPFALVSQRRSTFELQMVQMAQAADLPVLGICGGMQAMNVALGGSLFQDIASQVQTTLKHRQTARATRLSHAVRITQHSLLRRILGAATVRVNSSHHQSVKDVAPSLVASAVAPDGIVEAIESRKHRFFLGVQWHPEFLFERHRPHRRLFEAFLRAAQRRPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3F1</accession>
    <name>A0A1W1I3F1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47505">
        <property type="protein sequence ID" value="SLM47505"/>
        <property type="gene ID" value="NSJP_1333"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1333"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="56" mass="6527" checksum="AF1719765D127E48" modified="2017-06-07" version="1">MHLSIQFLISLGEPLRDLFYWHFNLKGSFHRPQLGHFHFHGLHSILLSSVPSCVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3I3</accession>
    <name>A0A1W1I3I3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47556">
        <property type="protein sequence ID" value="SLM47556"/>
        <property type="gene ID" value="NSJP_1384"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1384"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="109" mass="12560" checksum="2E93CB394819746F" modified="2017-06-07" version="1">MTFRQEQSIPFAAQAIPFDEFLAAGKLPDGYLPSEYLAQQFVERLVHYVLSVPAGSYTMAQLSHLLEQLDPRAQVFFFKRLKETSPDSLKDFAPLYYGFMNEFHSLLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3J4</accession>
    <name>A0A1W1I3J4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47413">
        <property type="protein sequence ID" value="SLM47413"/>
        <property type="gene ID" value="NSJP_1241"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1241"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="71" mass="8238" checksum="F8588E875C0E4E6D" modified="2017-06-07" version="1">MPEFLNPLFIVLYDRLYLLLQFLAMGKLLVYKQVHFAPISNTTCFCFAFILISDFGILPRDAKPNLLEALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3K3</accession>
    <name>A0A1W1I3K3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kinesin light chain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_1251</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the kinesin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1251"/>
    <dbReference type="EnsemblBacteria" id="SLM47423">
        <property type="protein sequence ID" value="SLM47423"/>
        <property type="gene ID" value="NSJP_1251"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1251"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002151">
        <property type="entry name" value="Kinesin_light"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="288"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="372"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="456"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="498"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="540"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="582"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="10">
        <location>
            <begin position="878"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM47423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1208" mass="130952" checksum="9566A097C85A686A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3M2</accession>
    <name>A0A1W1I3M2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1379"/>
    <dbReference type="EnsemblBacteria" id="SLM47551">
        <property type="protein sequence ID" value="SLM47551"/>
        <property type="gene ID" value="NSJP_1379"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1379"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="171" mass="19555" checksum="36F2996ADF2BDDD3" modified="2017-06-07" version="1">MTSPLAFDQLLIRRALESDIPSIVSFSAALARETEGRELDPARLRHGTLALLDSPTHGFFMVAETLRPDRRLVGQLMITFEWSDWRNGVFWWIQSVYVDSAWRRQGVFRRLHDAVMREATADPVVCGIRLYVEKANTLAKRVYDRVGLASSGYEVYETDFTLPKHTDLPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Q2</accession>
    <name>A0A1W1I3Q2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1423</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1423"/>
    <dbReference type="EnsemblBacteria" id="SLM47595">
        <property type="protein sequence ID" value="SLM47595"/>
        <property type="gene ID" value="NSJP_1423"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1423"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="5">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="336" mass="37499" checksum="5DDBD8D25B9F4E76" modified="2017-06-07" version="1">MAVMITEFIITSGEQPKRLDVFLVNRERDVSRSVLQRLITLGRIRINGELVKPSQKIKPGDKITMDVPKPEPLEIKGEAIPLEILFEDEHLLVLNKPAGIVAHPAPGNWSGTLVNALLHHFQTSGGTISTIGGKERPGLVHRLDKETSGVMVVAKNDQAHRHLALQFKQHTIARVYEALVQGIPKTGRGVIDLSIGRDSKERKKFSARTSRPRTSVTEYVVHCRYVKIAAHVLLYPRTGRTHQLRVHLSSLGHPILGDPTYGGRKVCRILELDVPRVMLHARTLGFTHPSTGEFQEYTVSLPDDMEEVRRYLEQTLPGQNRGASAAPLSYTKRVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I481</accession>
    <name>A0A1W1I481_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47679">
        <property type="protein sequence ID" value="SLM47679"/>
        <property type="gene ID" value="NSJP_1507"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1507"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="10"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="141" mass="15371" checksum="59461A73561ECE9C" modified="2017-06-07" version="1">MSEDGSAPISLLFVDPDTESRAYWVTGLKIASPGYVITEALDGQSALDLCQARTFDCVVLEAVLPDLSGFEVLMHLCPPTSTAIVPVVMLTKLVLARLSNLAKWNGAQAYLLKGYTSVDELDLTIRRAIKWANPTSRESQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I485</accession>
    <name>A0A1W1I485_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative TonB protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NSJP_1640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1640"/>
    <dbReference type="EnsemblBacteria" id="SLM47812">
        <property type="protein sequence ID" value="SLM47812"/>
        <property type="gene ID" value="NSJP_1640"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1640"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="11">
        <location>
            <begin position="273"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="191"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM47812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="351" mass="37436" checksum="CA2C53B90E9D4491" modified="2017-06-07" version="1">MTSTHDNRFHISGWGASLVLHAVVVALTLVFLARIDPVLKKETFRWEVALVEAPAPTPVPATPQSVAPPVQPKTRPAHVQPAPAPTPETPVQRVAPQESVQMVHPVVETPRPVEQKIEPLPQQKPEPVERQVEAVQHKAEPVIQKVEESPAVEPTVHAVETKSAEPVYAETVVAQHRPAVPVEAPAPAPTVQEVAVASPSPAAAADNPPTSAAEATQQPSTPAAASEQVDVAPASAPVETPRVVAKAATGMPETKADHRWLAESLWRRVAELKRYPHSARMNGLQGKVVLKAVIRSDGHLAEVSVQKSSGHSVLDTAAMEAVKLACPLHMKHELGKPQIVVSLPIVYSLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4A4</accession>
    <name>A0A1W1I4A4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1685"/>
    <dbReference type="EnsemblBacteria" id="SLM47857">
        <property type="protein sequence ID" value="SLM47857"/>
        <property type="gene ID" value="NSJP_1685"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1685"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="98" mass="11334" checksum="394D2E386376A991" modified="2017-06-07" version="1">MAVTLINVFSVPKGQEEAFVKWWEDVKADITSQPGFISGKFHRSLKPDSKFNFINIAIWDNEEIYWKAYEKSVTPMKAKLAQLGVEMVPALYRVAFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4A5</accession>
    <name>A0A1W1I4A5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Cation efflux system protein CzcC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1662"/>
    <dbReference type="EnsemblBacteria" id="SLM47834">
        <property type="protein sequence ID" value="SLM47834"/>
        <property type="gene ID" value="NSJP_1662"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1662"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="417" mass="45750" checksum="5F485123A1EA4AA1" modified="2017-06-07" version="1">MPYSAVCLIAIVSFLEIMWSALPAVADSDVVQFKLEEVIEMALNRSPAMSAAKGGVRQIEGERMAAGAYPNPSFSAVFGPGKTRESLGDISFFERTLTLSQPIETPGIRQARQRGAEAALAGSQAAVGEARLSVLSDVKVAFYQLLLAQRDVELTMQARILVQDLFRGIKARVDAGQARPFEAIKANVELQTVSNELSRAQNSLVAVRARLDALTAGGLGSEFSVQGDFQAPRNTFNRHEMISSALEHHPTVQRLDKMIEKAEQQAVQERKSVVPLVTVSGTYKQEAAESAYLAQLSIPIPLWYRRQGEIAAALGAKERTEAERVRAQNEIATSITEQVQEARTAVQQIDVFEKGLLKQAEEAVWIARISYQQGATGLLDLIDAQRVHRQTLFQYTQARAAFSVALARLERWTGALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4B3</accession>
    <name>A0A1W1I4B3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1670"/>
    <dbReference type="EnsemblBacteria" id="SLM47842">
        <property type="protein sequence ID" value="SLM47842"/>
        <property type="gene ID" value="NSJP_1670"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1670"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024208">
        <property type="entry name" value="DUF3842"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12953">
        <property type="entry name" value="DUF3842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="141" mass="15118" checksum="C2DD5D895182EA85" modified="2017-06-07" version="1">MRVCVIDGHGGGLGSRLVRELRADLSPGHELIGLGMTQAAAAAMGEAGAARICIGPEAITETVRTADVILAPLNVLFPDRDQREVTATMVQTILEARCRKILLPLNRFRVEVAGTESHKLEHLITTSLSRVRTLLSAVPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4P0</accession>
    <name>A0A1W1I4P0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1677"/>
    <dbReference type="EnsemblBacteria" id="SLM47849">
        <property type="protein sequence ID" value="SLM47849"/>
        <property type="gene ID" value="NSJP_1677"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1677"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37309">
        <property type="entry name" value="PTHR37309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="132" mass="14069" checksum="4979182EBC54F3A8" modified="2017-06-07" version="1">MQSAVVRIVITGIAVFLAVATVPGIEVRDMTAGVAAVLVLTILNLLIRPILLILTLPLIVLSLGLFLLVVNAILLELTAYLVKGFTVSGFWPAVGGALVISIVTSILNLFTSDSHRVEVRHSEPRPPKIINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4P8</accession>
    <name>A0A1W1I4P8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">mutM</name>
        <name evidence="16" type="ORF">NSJP_1798</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1798"/>
    <dbReference type="EnsemblBacteria" id="SLM47970">
        <property type="protein sequence ID" value="SLM47970"/>
        <property type="gene ID" value="NSJP_1798"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1798"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="15">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="14">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SLM47970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="294" mass="33475" checksum="4D334B532D6364F7" modified="2017-06-07" version="1">MPELPEAEVVARQIRSRLTGARLIDAVLGRRDIVREGVGTLSWYRKTRLVSVERYGKSVALRFEKGTEARYVVAELGMTGLLLFDAVPIRHPRHVHAELIFEGSAERALRYWNPRRFGRLSLLDASGLDRYISRRFGYDPLTVSREEFAGLLSHRRGRLKSLLMHQQTVAGIGNIYANEILFRAGLHPNALPNRLRPDRIDRLFRITREVLTQAIDCGGSSVRDFFAPDGTEGMYKRHHLVYGKEGEPCPNRCGETIRRLQSERSSFICVSCQGRRGPARAFRTNEEAASIKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4T1</accession>
    <name>A0A1W1I4T1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Surface antigen D15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1842"/>
    <dbReference type="EnsemblBacteria" id="SLM48014">
        <property type="protein sequence ID" value="SLM48014"/>
        <property type="gene ID" value="NSJP_1842"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1842"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Omp85" evidence="2">
        <location>
            <begin position="92"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="400" mass="44483" checksum="C3D15BF9D725502C" modified="2017-06-07" version="1">MMTLRGIVLFFACLLAGIAIVRIGPARADTQLFPIPSVSTSKNDGSDAGLIVPILVTDPDGELKYLMAPMLIRNSIVGWRGTFNLFRYDTGGRQMQFIASISEKIERKLVFNYTDPAFSNGRYFLNVGAAYFKNATARFFGIGQTTTEGEETNYTAKESRANWRFGLYANEVTQVAISQRFRAVQLQPGATDLPFTGNVFPTVPGVEGETYILGNRATFYYDTRNSLVSPTDGMAVTAYAELNNNFKNGDHPIYSRYEFEVKKLFPSESKRAILVVRADLQATIGEQVPFFEQSSLGGQNNLRGYGVDRFIDKNLVAFSLEERIHLARMKVAGVIADFEVAPFLDTGQVFDSFKDVSFKDYRMTPGMGFRGIVRPNVVGRIDYGYSKEGGAIFAGLDFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4V2</accession>
    <name>A0A1W1I4V2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoglutarate:ferredoxin oxidoreductase epsilon subunit</fullName>
            <ecNumber evidence="2">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">forE</name>
        <name evidence="2" type="ORF">NSJP_1789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.3" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1789"/>
    <dbReference type="EnsemblBacteria" id="SLM47961">
        <property type="protein sequence ID" value="SLM47961"/>
        <property type="gene ID" value="NSJP_1789"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1789"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="107" mass="11605" checksum="1D96E06C71A89CD4" modified="2017-06-07" version="1">MYLVADIDVEICAAKSCKLCTQYCPEANTILYSDEMGKDKGFKYGSAYVAVDRCKGCAQCVWVCDNMAKNNAIKMIMIDQLPKAALTDNITYGEKSTTAVLASPVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4W6</accession>
    <name>A0A1W1I4W6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47929">
        <property type="protein sequence ID" value="SLM47929"/>
        <property type="gene ID" value="NSJP_1757"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1757"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018550">
        <property type="entry name" value="Lipid-A_deacylase-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09411">
        <property type="entry name" value="PagL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="195" mass="21734" checksum="2ED03EC6C52993C4" modified="2017-06-07" version="1">MRQARGRGKLRYACVVWLWIVGVGSLGWAGEFRLESLAVRGGFSGISPLEEEQKYYFRQADLVLTARLPWERDLGTDWVLGTKLLTSGGVLNAAQETNGIFTLVPLDVLIGRKDGLLSFDMGIGGALLTDHKYGVQNFGGAFQFVWTFGVTSRFLGPLGLGYHFQHYSDATLYGSHSRGGDFHLFELIYWFKTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I598</accession>
    <name>A0A1W1I598_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48059">
        <property type="protein sequence ID" value="SLM48059"/>
        <property type="gene ID" value="NSJP_1887"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1887"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="82" mass="9287" checksum="C6C682786BA88817" modified="2017-06-07" version="1">MASKKQQFKQPANTLRFGNIKATIWENGSENGPFFATTFSRPYKDQSGAWRNGASFGLNDLEALRTVARQAQEWIATHALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5C2</accession>
    <name>A0A1W1I5C2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Penicillin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mrdA</name>
        <name evidence="5" type="ORF">NSJP_2030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2030"/>
    <dbReference type="EnsemblBacteria" id="SLM48202">
        <property type="protein sequence ID" value="SLM48202"/>
        <property type="gene ID" value="NSJP_2030"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2030"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017790">
        <property type="entry name" value="Penicillin-binding_protein_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03423">
        <property type="entry name" value="pbp2_mrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="67"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="267"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="626" mass="67904" checksum="E68495EB2E37C10C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5E1</accession>
    <name>A0A1W1I5E1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Amidase enhancer protein LytB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2023"/>
    <dbReference type="EnsemblBacteria" id="SLM48195">
        <property type="protein sequence ID" value="SLM48195"/>
        <property type="gene ID" value="NSJP_2023"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2023"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013486">
        <property type="entry name" value="SpoIID/LytB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013693">
        <property type="entry name" value="SpoIID/LytB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30032:SF4">
        <property type="entry name" value="PTHR30032:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08486">
        <property type="entry name" value="SpoIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02669">
        <property type="entry name" value="SpoIID_LytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoIID" evidence="1">
        <location>
            <begin position="144"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="411" mass="44214" checksum="3E4315736C47A70D" modified="2017-06-07" version="1">MDVSTVISICRWGMAVVVGVLVTLGTAPLQAAQSLRVLLAADVVKLDVQSNSSVWVSDSSRHGKAVRPAVRIVPAGKGFMVNGVRMMHEQLTLQGEQGLTLTFVKADGTAGTNGRGAIKAATIQRVTVPVSGLVHVVRRGVGALVINQVDLEEYVKGVVPAEVNSSWHPEMLKAQAVAARTYALYQQMLSANRDYDVVASVQDQVYRGKQGVDGAVLKAVEETRGLVLTYQGAPIYAAFSSTAAGLTEDAVNVWSKDYPYLKGVECPFDLASPYYQWTASFRKELLEHNLRQQGFPIGMITALTPSSFSRGGRVATLRVAHTEGELILRGEELRKAVGYMVVPSTQFTVESVGSEIVLSGYGAGHAVGMCQWGAKELAELGYPFSTILSYYYPDTQLQDMALTKAPIPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Q9</accession>
    <name>A0A1W1I5Q9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxxC_CXXC_SSSS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48358">
        <property type="protein sequence ID" value="SLM48358"/>
        <property type="gene ID" value="NSJP_2186"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2186"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="107" mass="11870" checksum="A288AA958D4B052B" modified="2017-06-07" version="1">MPIYEYRCGQCEKVFEATQSVHARTEDTVCPFCQAQDATKLLSSFASKVVGTHKTGFAEMKAYNMLNERMDKFSKLPPVMGTRAMPPSDLFSSLETPPAPSKPSQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I602</accession>
    <name>A0A1W1I602_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protease HtpX homolog</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">htpX</name>
        <name evidence="9" type="ORF">NSJP_2264</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48436">
        <property type="protein sequence ID" value="SLM48436"/>
        <property type="gene ID" value="NSJP_2264"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2264"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="93"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="305" mass="33559" checksum="E46E11CBCFC31E34" modified="2017-06-07" version="1">MKWLKGITLFLIANVLIYLTLSVTASILINVVLPAFGIDVRGVFSQQLLVWSLVIGFGGAFISLLFSKQMARAMLHCQQITEPRSHAEQVIYGSVKEIADRLHVTMPEVWVYDAPDPNAFATGPSKNNSMVAVSTGLLQNLKEDEVKAVLAHEMGHVFNGDMFTTTILAGLMNTFVYYISNMLASMVGQPSGDREEGGSTGNPILAMVVYFFLQIVLSFLAMIVVSWHSRRREYEADAFSAKVYGKQSMIGALQGIDRWVNRTQFEYTNQDALATMKISGTSSGVMALLATHPPIEARIAALQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I615</accession>
    <name>A0A1W1I615_9BACT</name>
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        <submittedName>
            <fullName evidence="7">Putative Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_2280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="NSJP_2280"/>
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    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome_CBB3"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013366048" evidence="5">
        <location>
            <begin position="25"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="42"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="133" mass="14142" checksum="74F50A0A908EB5CE" modified="2017-06-07" version="1">MRLNRTAGFRWSWGLAGVLLVAMAACDPPQPTPAAGGAATPAELQAGEAKFNANCSVCHGQQGTGTAQGPPLVHKIYEPNHHGDAAFQRAAAGGVRAHHWEFGNMPKIDALTSADVDQIIQYVRWLQKQAGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I629</accession>
    <name>A0A1W1I629_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48466">
        <property type="protein sequence ID" value="SLM48466"/>
        <property type="gene ID" value="NSJP_2294"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2294"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="177" mass="20456" checksum="6AFE04E591040AA6" modified="2017-06-07" version="1">MGFSLHNLEMGISMYKSYLLLVLTLMLWSIPSESLALRSAMTGVNFDDVELTLLVPPAYYEQLYDRAIEAFAKAGLRPKREIDRTILQEGKGYILFIELWAKSIETCPGHYRYEQTAELQEWVYFDRIGERLLMSSPMGSDNSLVVTAKPDLTRLQRDLDDLLAVIIQHYRVVNMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I642</accession>
    <name>A0A1W1I642_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Alanine dehydrogenase</fullName>
            <ecNumber evidence="2 4">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ald</name>
        <name evidence="10" type="ORF">NSJP_2273</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="2 4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2273"/>
    <dbReference type="EnsemblBacteria" id="SLM48445">
        <property type="protein sequence ID" value="SLM48445"/>
        <property type="gene ID" value="NSJP_2273"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2273"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000183">
        <property type="entry name" value="Alanine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00518">
        <property type="entry name" value="alaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="9">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="8">
        <location>
            <begin position="149"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM48445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="367" mass="39027" checksum="5E276C33FB69A118" modified="2017-06-07" version="1">MIVGVPREIKDHEYRVGLTPDGARALHQAGHQVLVEISAGEGSGFTDEEYRQAGASIIQSAAEVFERAALIIKVKEPLLSECRLLHAGHILFTYLHLASSAELTKKLMESRVTAIAYETVEAKDGTLPMLRPMSDIAGRMSVQIGARYLEKTQGGRGLLLSGMPGVEPAHVVVLGAGVVGSAAVRIATGMGARVTVINLDLERLRILDEQYQGRIVTRAATQAAIEESVPTADLLIGAVLVAGARAPKLVSRRLVGRMRKGAVIVDVAVDQGGCIETTKPTTHSDPVYFVDGVLHYCVANMPGIVPRTSTGALTNVTLPYVLRVAADGVEPVMRSDAGFRKGVNLYNGDVTCPAVADAHGLRFTPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I649</accession>
    <name>A0A1W1I649_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable endolytic peptidoglycan transglycosylase RlpA</fullName>
            <ecNumber evidence="3">4.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rlpA</name>
        <name evidence="6" type="ORF">NSJP_2314</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the RlpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2314"/>
    <dbReference type="EnsemblBacteria" id="SLM48486">
        <property type="protein sequence ID" value="SLM48486"/>
        <property type="gene ID" value="NSJP_2314"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2314"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02071">
        <property type="entry name" value="RlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034718">
        <property type="entry name" value="RlpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012997">
        <property type="entry name" value="RplA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00413">
        <property type="entry name" value="rlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPBB_1" evidence="5">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="211" mass="22278" checksum="EFD8902A9FE1D03A" modified="2017-06-07" version="1">MTVHATPSPCTAALAVALGAWCLVGGCSWIPKGDSQFDAGIKDRGIASWYGEPFHGRQAADGTIYDMEGLTAAHRTMPLGSVVRVTNLTNGKYVYVRITDRGPYVNGRILDLSHAAAVRVGMVKGGLSLVQVEIVGERRPDALLSSDAVAALSLARIVRADSTAQPDGVALGAPHRPRPGDLWTRRRNLSVPATLAADHTAHVQLAALVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I694</accession>
    <name>A0A1W1I694_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 2-hydroxy-6-ketonona-2,4-dienedioate hydrolase</fullName>
            <ecNumber evidence="2">3.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.7.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2181"/>
    <dbReference type="EnsemblBacteria" id="SLM48353">
        <property type="protein sequence ID" value="SLM48353"/>
        <property type="gene ID" value="NSJP_2181"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2181"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="42"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="299" mass="32902" checksum="BB584D3722EA04D9" modified="2017-06-07" version="1">MTACSSPAPIPTQFEAFERIPIRTASVHGHKIAYLDVGQGDAMILLHGFGGSMWQWEHQQPVLGRHVRLITPDLIGSGLSDKPDIAYTTGQLLDYFTGFMDALHLSRATLVGNSMGAGLAIGMALTHPERVDKLILIDGLPSHVASKLTSPTIKRALESRAPAWMVSFGNWLFGGLMLESVLKEVVHDPALLTPAVLERSDRNRRRPGLIPPLMALRDSLPVWETDFAPRLGTLTHPTLILWGQEDRVFPLAVGEDLHRTIHGSKLVTIPHAGHIPQWEQPEQANQAIMEFLTSRTAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6G4</accession>
    <name>A0A1W1I6G4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">adk</name>
        <name evidence="10" type="ORF">NSJP_2359</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2359"/>
    <dbReference type="EnsemblBacteria" id="SLM48531">
        <property type="protein sequence ID" value="SLM48531"/>
        <property type="gene ID" value="NSJP_2359"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2359"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADK_lid" evidence="9">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="126"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <begin position="136"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
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        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>AMP</name>
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        </ligand>
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        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SLM48531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="218" mass="23919" checksum="EE2987A3E9B7EBCA" modified="2017-06-07" version="1">MRVVFLGAPGVGKGTQADRVAAASKSVKLSTGDLLREAVRNQTTLGREAKGYMDQGKLVPDSVVIGLVREKLADLSGANGFILDGFPRTVVQAEELNRVLASANTPLDRVVNFQVSREDVVRRLSGRRSCPKCQATFHVDFAPSKKGNVCDRCGEPLVQRSDDRPEAIETRLKVYEEQTAPLIRYYRERQLLSELDGSGSVDAVFEGLSRVLAPYRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6K9</accession>
    <name>A0A1W1I6K9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="32"/>
            <end position="60"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="123"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="123" mass="13682" checksum="332D085BACF41358" modified="2017-06-07" version="1">MWRPAGAMTATGRCKTQSVHARWNHGQHLEWVKESFNGKSEKTTGEEKDESKRQESGEDTCEEIVREVFRGKSEEAIRERACAQSGSRPQTGGALREEAGEARRGRRNQKAGVLQTDSQAAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6N9</accession>
    <name>A0A1W1I6N9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2531</name>
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    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
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        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="396" mass="46031" checksum="869552F36AA94280" modified="2017-06-07" version="1">MNDSLRDRLLTDLVRELDIPDNAYEAAESRYHDLGEWLRDESKAKIAQFQPLVSAQGSFRMGTVTKPWKTDHHDLDIGCSLQEGITPETCTQYDLKHLVGSDLYTYRSERRIQDEPEEKHRCWRLNYQDNLHFHADVVPCVPHSERIQAIIKSRMLQTGTSPLLAQDISKLAVAITDDRHPGYRRLDHDWYISNPEGYARWFESRMKQAHALLKSRTLQAKVGRIEDLPVFRWKTPLQAAIQILKRHRDVMYENLPERKPISIIITTLAAHAYRGEFDLSDALIQILDNMCVNPSEPRVPNPVNAQEDFADRWKSSEGRALRLEENFFVWLEQAKRDFYAILSPSDYGMLPEHIRKRFGVSINQDLMRQISGTLSPRISSPALHIKREMVPKPWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6P6</accession>
    <name>A0A1W1I6P6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Quinol-cytochrome c reductase, fused cytochrome b/c subunit</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">qcrB</name>
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    <organism evidence="15 16">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2514"/>
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        <property type="protein sequence ID" value="SLM48686"/>
        <property type="gene ID" value="NSJP_2514"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2514"/>
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        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome_b_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005798">
        <property type="entry name" value="Cyt_b/b6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036150">
        <property type="entry name" value="Cyt_b/b6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003468">
        <property type="entry name" value="Cyt_c_oxidase_monohaem-su/FixO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00032">
        <property type="entry name" value="Cytochrom_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00033">
        <property type="entry name" value="Cytochrome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02433">
        <property type="entry name" value="FixO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81648">
        <property type="entry name" value="SSF81648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51003">
        <property type="entry name" value="CYTB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="12">
        <location>
            <begin position="5"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_CTER" evidence="13">
        <location>
            <begin position="218"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="14">
        <location>
            <begin position="358"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SLM48686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="442" mass="48800" checksum="CC938621EBFE0F5B" modified="2017-06-07" version="1">MASRIYAWLDSRLNLKAVEHSLLDEPIPGGASWIYVFGSATLFLFVLQAVTGMFLAIYYAPTPDHAYDSVQFIENQVTFGWFVRGLHHWGASGMVIAVGLHMLQVFLYGAFKPPRELMWMVGVVLLLLVLGFAFTGYLLPWDQTAYWATQVGINMVGTVPLVGDFLVKVMRGGETLGALTLSRFFAVHVLFLPAVIVTGIMLHLFILRRVGPAGPWDEKKAAAGSETFHPRQVYMDAVVMVGVFALLVLLACLVPFPLADKANPADTSFVPVPEWYFLFYYELLKYVHGPLEPVATWILPGLFIAALLLWPFLDWQKTVRAPASRPVGMALGAIFLLVVFSLLGVSLKSLYGVKRADPGVAHGQALFASLGCTGCHRIHGTGGAIGPDLSYVGDERPDREWHMKHFRDPQSVSPGSIMPKFPLSEQELRDLTSYMVSLKKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6R3</accession>
    <name>A0A1W1I6R3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="5">FGAR amidotransferase II</shortName>
            <shortName evidence="5">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">purL</name>
        <name evidence="9" type="ORF">NSJP_2449</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2449"/>
    <dbReference type="EnsemblBacteria" id="SLM48621">
        <property type="protein sequence ID" value="SLM48621"/>
        <property type="gene ID" value="NSJP_2449"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2449"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001587">
        <property type="entry name" value="FGAM_synthase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01736">
        <property type="entry name" value="FGAM_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="8">
        <location>
            <begin position="14"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="86"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="201"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="440"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="570"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="93"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="311"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="748" mass="81269" checksum="91602C7F28330377" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6W4</accession>
    <name>A0A1W1I6W4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48553">
        <property type="protein sequence ID" value="SLM48553"/>
        <property type="gene ID" value="NSJP_2381"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2381"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="67" mass="7387" checksum="9B777335402CA24F" modified="2017-06-07" version="1">MEASISTLESIRLTGGGGSFYKYARLTASAADKGVRIWTAKDEDMRKGQWRPFGPSCGPEGRFFILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Z3</accession>
    <name>A0A1W1I6Z3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="8">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">proS</name>
        <name evidence="10" type="ORF">NSJP_2619</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2619"/>
    <dbReference type="EnsemblBacteria" id="SLM48786">
        <property type="protein sequence ID" value="SLM48786"/>
        <property type="gene ID" value="NSJP_2619"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2619"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001535">
        <property type="entry name" value="ProRS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="33"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM48786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="572" mass="63607" checksum="C1C6E5BB8D0FDCDB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I751</accession>
    <name>A0A1W1I751_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative flavin-containing monoamine oxidase AofH</fullName>
            <ecNumber evidence="4">1.4.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2584"/>
    <dbReference type="EnsemblBacteria" id="SLM48751">
        <property type="protein sequence ID" value="SLM48751"/>
        <property type="gene ID" value="NSJP_2584"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2584"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="443" mass="48992" checksum="EE22A3CECC6F4DF6" modified="2017-06-07" version="1">MTRSLRDKSVIVVGAGLAGLTAAVELQKQGMAVTLLEGQERVGGRVLTIRDGFVDGQYAEAGAEFIDEDHEEICRLIRSLRLRLTPVLREGFGFALSSGGRVRRLSGDGMWKRLAEQLAPMIRAYRLSEQRWDGRVAAELGARSVAEWMKSRRLSKELREMLVGLRGFFLADPADLSLLSLVDQVASGSPGKGGMYRIAGGNDRLPEGLAAMLSDRLLLRHEVLAISRSKQSVRVRVRAGSQESWLRADYVILAIPATKIRTLDITPALPPEQAAAFSTLRYGPVTKVLLQFDRRFWKRRNQPLAYGTNLPIGALWDANEQQKGRQGILCLMAGGQASRATRTLASRTGSAGLVQTLRWLGAPGKQAVAMRMVTWERNQWIRGGYAVFGPGFDPKLRSWLARPCGRLFFAGEHTSLRWQGYMNGAVESGFRAAAEIQADIRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I758</accession>
    <name>A0A1W1I758_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48846">
        <property type="protein sequence ID" value="SLM48846"/>
        <property type="gene ID" value="NSJP_2679"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2679"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="142" mass="15768" checksum="0B1C996955D8CD30" modified="2017-06-07" version="1">MMDMEIGSNVYRNTNGTVEIEGIPQVQIELKEPSKAVLVSFALFDANGKMIAKLVDSTLTFNERRAYELDKTPTRLTLMHSESKNVVLQIDVKSPNQVVFSKAGFHSIKGHLLEVSEKEWKIDRQKSSGAMEDVNGGSVKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I772</accession>
    <name>A0A1W1I772_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_2689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2689"/>
    <dbReference type="EnsemblBacteria" id="SLM48856">
        <property type="protein sequence ID" value="SLM48856"/>
        <property type="gene ID" value="NSJP_2689"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2689"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="285" mass="30917" checksum="3F943B7FB03040AD" modified="2017-06-07" version="1">MAYYTVFSIVPLLVVIIAMIGLVFGQEAAQSYILQQISVLIGEQSADAIKDMIQRATKPTTGILATMIALATLLFGASGLFGELQDSLNTIWGVELKEGRGMTGLIRDRFLSFLTILGTGFLLLVSLVMSAGLAATGKWFEGWLPLPEFLLHALNLLVSVIVITGLFAMMFKVLPDARVAWSDVWIGSLMTAVLFTIGKFAIGLYLGKSDIGSAYGSAASLVIVLLWVYYSAQIFLFGAEFTKVYANTYGGRIMPSENATSTQDPQVSVRLPESKDRSRHRQPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I784</accession>
    <name>A0A1W1I784_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48781">
        <property type="protein sequence ID" value="SLM48781"/>
        <property type="gene ID" value="NSJP_2614"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2614"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="97" mass="11124" checksum="D1639809B332D421" modified="2017-06-07" version="1">MQGTPTQDGGGLQFLRDRVVWSWTQGHLQDHLPGRQDAEVQLRLSQEFWTDVHGLQGELYLRIGGIPAWNPRTIEEQSPPDRLYHSQEDGYTPPAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7G2</accession>
    <name>A0A1W1I7G2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48743">
        <property type="protein sequence ID" value="SLM48743"/>
        <property type="gene ID" value="NSJP_2576"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2576"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="102" mass="11709" checksum="54AD4FA02B1B8CFE" modified="2017-06-07" version="1">MPHVLIIHEVDAYTAWKTVFDRAADIRTLAGEISYQLLRYDTDANTVVHFSKWTSLDDARRFFESPELVEIRRKAGVKAPTFLYLREIERGVLSPERGSGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7N8</accession>
    <name>A0A1W1I7N8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Molybdate/tungstate import ATP-binding protein WtpC</fullName>
            <ecNumber evidence="9">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">wtpC</name>
        <name evidence="9" type="ORF">NSJP_2838</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2838"/>
    <dbReference type="EnsemblBacteria" id="SLM49005">
        <property type="protein sequence ID" value="SLM49005"/>
        <property type="gene ID" value="NSJP_2838"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2838"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Mop" evidence="8">
        <location>
            <begin position="296"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="365" mass="38822" checksum="B32B37FEAF54E8F4" modified="2017-06-07" version="1">MAAEIAIDIHKTFPGRATIRARIRYPVEASTVLILFGPSGSGKTTVLRSVAGLECPEQGTIRFISRTWLDTAAGVNISPQDRRIGYMAQEYALFPTYTVAGNIAYGLGHLSVSDRKRRVSEVLELFQLGGLESVKPRELSGGQQQRVALARAVAPRPQLLLLDEPLSALDAPTRIRLRGELRSLLKQLALPSIIVTHDREEALALGDVMAAMSDGAVLQVGTPQDVFSRPANAEVAKIVGVETVVQGRVLQAADSLVTIEVGEQTLTALDGPELGSAVFVCIRAEDVMLEKIGTAPTSARNHVKGIVRDIASAGPLVKVSLDCGFPLGVLVTRSALEELGLEPGSPVRAAIKAGSVHVVPRQEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I838</accession>
    <name>A0A1W1I838_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2806"/>
    <dbReference type="EnsemblBacteria" id="SLM48973">
        <property type="protein sequence ID" value="SLM48973"/>
        <property type="gene ID" value="NSJP_2806"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2806"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="420" mass="47932" checksum="5EBDAB5C4774E6B4" modified="2017-06-07" version="1">MAHRQAAHSEYPDSIPFSLFEGDFLTRFFQRIGMGSYRTGDLVKRALFLMTLTWGVLAALAVWSGLHWTQPRGQNFFFDFAAYGQLIAGLPMFLVAERVIDRQTKEVARCFVTTGVVEPGDAIRLVRVNWQLKQSRHKAWPDLLCILLGYAITAAWMIPEMNNGRLTWHATDLDSHLQPMTWYGFREMLQTLTWPGAWEFIFVGPLTTYWWLRWSVKVLLWTWYLYQVSNLRLNLVPSHPDSTGGIGFLSDAQTKFGWIILAYGISYVAPTILYKLTFEGATILVLSVWGYAASFVIGAPVLFTLPLFMFTQQLSQAKSRALEVLQERSMERAQAFEEKWLKACTSGHYELMSGSDLTGLDALNRVYDHIHKMRVVPFDLRSFSELVGSALGPMVPLLPYIVDIPEPFLKAIEEGKKLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I887</accession>
    <name>A0A1W1I887_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49227">
        <property type="protein sequence ID" value="SLM49227"/>
        <property type="gene ID" value="NSJP_3060"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3060"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="94" mass="10617" checksum="1968C9DE3831C7E2" modified="2017-06-07" version="1">MSMPTATPSEFITRVDFGKYWDHFLGAGPLDAISRRALVQAKDELLTAGVPTFTVIAYFRHLYYRMGNDVLIGLVEEIISDLEDLAHLEESLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8A4</accession>
    <name>A0A1W1I8A4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Helicase (C-terminal)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3085"/>
    <dbReference type="EnsemblBacteria" id="SLM49252">
        <property type="protein sequence ID" value="SLM49252"/>
        <property type="gene ID" value="NSJP_3085"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3085"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="619" mass="68917" checksum="EEDD770DCF0DB5FB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8E4</accession>
    <name>A0A1W1I8E4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD_binding_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3107"/>
    <dbReference type="EnsemblBacteria" id="SLM49274">
        <property type="protein sequence ID" value="SLM49274"/>
        <property type="gene ID" value="NSJP_3107"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3107"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="7"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="88" mass="9443" checksum="B20411D763900FD1" modified="2017-06-07" version="1">MAELIEETDVAVVGAGGGGAVLALAIAQKGIRTVVLDQAPGPPQGLRGEILHRTGRRCWIGSVCCNPCRPSSEPTGRFRRYGERWLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8H9</accession>
    <name>A0A1W1I8H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49314">
        <property type="protein sequence ID" value="SLM49314"/>
        <property type="gene ID" value="NSJP_3147"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3147"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="49" mass="5897" checksum="B00910132220EC65" modified="2017-06-07" version="1">MRRRASHVREYFGSRVLALIQYNWNGREDYIGQGAATQTDDRRRRRELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8K7</accession>
    <name>A0A1W1I8K7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49325">
        <property type="protein sequence ID" value="SLM49325"/>
        <property type="gene ID" value="NSJP_3158"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3158"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="91" mass="9677" checksum="15EA8E9EC4E17E3E" modified="2017-06-07" version="1">MTAILNLIYCWLLDLLAKLTDIALNAWDSVLGPADSILTSIGTGSLTVPVIPAQYAWILGATGMAQAVAIIATAMLVRFTLQSVPFVRWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8N2</accession>
    <name>A0A1W1I8N2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3114"/>
    <dbReference type="EnsemblBacteria" id="SLM49281">
        <property type="protein sequence ID" value="SLM49281"/>
        <property type="gene ID" value="NSJP_3114"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3114"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021809">
        <property type="entry name" value="DUF3386"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11866">
        <property type="entry name" value="DUF3386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="224" mass="25068" checksum="F6E55CC79905D57F" modified="2017-06-07" version="1">MDAHTPQQPTVADDPRAREALRKAFENTARWQKDFKGFTADLTVNVDGAESAGPIMVKGPREVSVQLPDADIQKWAQEQLGMIAVHRGPRSFEESDGKYSLTMEEDGHPLGIKLNIHGSNSFYRLKNDRITQINRTMAHPGMAPFAFTINVEDSAVTQDGKNLTTRYTVYYYAPKDGKLNNVESFSDSHVRIGNSDLPGTRRIISYENGRVTVKSLTFSNHKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8U7</accession>
    <name>A0A1W1I8U7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="3">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_3253</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3253"/>
    <dbReference type="EnsemblBacteria" id="SLM49420">
        <property type="protein sequence ID" value="SLM49420"/>
        <property type="gene ID" value="NSJP_3253"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3253"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0680">Restriction system</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_Mtase" evidence="7">
        <location>
            <begin position="133"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Methylase_S" evidence="6">
        <location>
            <begin position="459"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Methylase_S" evidence="6">
        <location>
            <begin position="682"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="841" mass="94420" checksum="ACB6B822ADD8526E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8W4</accession>
    <name>A0A1W1I8W4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Efflux pump membrane transporter BepE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bepE</name>
        <name evidence="6" type="ORF">NSJP_3285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3285"/>
    <dbReference type="EnsemblBacteria" id="SLM49452">
        <property type="protein sequence ID" value="SLM49452"/>
        <property type="gene ID" value="NSJP_3285"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3285"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="874"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="899"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="974"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1006"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1039"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1039"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1062" mass="115114" checksum="1F0B4E7AB48BF454" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Y0</accession>
    <name>A0A1W1I8Y0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent RNA helicase RhlE</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rhlE</name>
        <name evidence="11" type="ORF">NSJP_3295</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3295"/>
    <dbReference type="EnsemblBacteria" id="SLM49462">
        <property type="protein sequence ID" value="SLM49462"/>
        <property type="gene ID" value="NSJP_3295"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3295"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="38"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="236"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="366"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM49462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="416" mass="44556" checksum="E65CCE86F5E566F5" modified="2017-06-07" version="1">MHTTVPTSFHALGLSKGLLHNLTKAGFQNPSAIQAEAIPHALAGRDVLGCAQTGTGKTAAFVVPLIERLAADPKGHPRALILAPTRELAIQIQSTIDRLAKNLGVFATTLVGGADMQAQVRGLQQRPDILVATPGRLLDHMWNGTINLGLMEILVLDEADRMLDMGFAPQINQILDALPEDRQTLLFSATLPADLTRLVQANVKDPVHVTVTPPATTADGVTQALHHTTHARKGELLVSLLGAEKETVLVFTGTKHRADRIGRLLGEAGHKVAVLHGDRTLPQRRAALEGFKRGTYRVLVATDIAARGIDVANIGHVVNYDLPQCPEDYVHRIGRTARMKTTGRATSFVTAEDRPQLLAIESLLGQPVPLAPGSPAPRPNGHGNEGGDRGHAGRSRRSNHHRRPMVQAPASGQSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Z9</accession>
    <name>A0A1W1I8Z9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49470">
        <property type="protein sequence ID" value="SLM49470"/>
        <property type="gene ID" value="NSJP_3303"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3303"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="118" mass="12747" checksum="0510AD83A2EFEB7D" modified="2017-06-07" version="1">MTDVKFIRSTVTAISLGIASAWFFVPEAQTQSRPSSPRTVTGQVSAVEGNFHMAKDGGGKDILQFVDKAYTITTPTGQEIELTLTRETRVPARANPGDRVEAQISEKGQALSVKLIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I945</accession>
    <name>A0A1W1I945_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized oxidoreductase YrpG</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yrpG</name>
        <name evidence="2" type="ORF">NSJP_3348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3348"/>
    <dbReference type="EnsemblBacteria" id="SLM49515">
        <property type="protein sequence ID" value="SLM49515"/>
        <property type="gene ID" value="NSJP_3348"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3348"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="322" mass="36337" checksum="0686BCE46BD8852C" modified="2017-06-07" version="1">MQYRHLGRSGVRVSRLCLGTMNFGPQTSEMDSFTVMDRALELGINFFDTANVYGWKTGEGWTEQIVGRWLAQGGRRDQIVLATKVYGRMGDRPNESRLSALHIKRACEASLRRLHTDCIDVYQMHHIDRDTPWDEIWQAMEQLVREGKVIYIGSSNFAGWHLAQAQELARNRHFLGLVSEQSLYNLTERTIELEVIPACQAYGIGLIPWSPLARGLLAGALESAAAGRRADPEVRKDVDTHRHKLETYEALCRRLGERPADVALAWLLHQESVTAPIIGPRTVEQLNESIRALALTLNRETLKRLDEIFPGPGAPAPEAYAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I962</accession>
    <name>A0A1W1I962_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal-protein-alanine N-acetyltransferase (Modular protein)</fullName>
            <ecNumber evidence="3">2.3.1.128</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.128" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3369"/>
    <dbReference type="EnsemblBacteria" id="SLM49536">
        <property type="protein sequence ID" value="SLM49536"/>
        <property type="gene ID" value="NSJP_3369"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3369"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="189" mass="20081" checksum="F5E78B4F86906C7E" modified="2017-06-07" version="1">MTVSPCEILPATDADLSDILAIEEACFSAPWTRKMMEAEMSGNPFAHFLVARRATAEGGTSASIVGYVCFWIVFEEVRLMNLAVIESMRCKGIATSLVTAALQAGALQSAVRAVLEVRASNGAAQTLYQNLGFRQTGLRPNYYSAPLEDAVLMELDSLAPEAGNRSLAGDHTEGHPSMGQPLKPGGATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9B2</accession>
    <name>A0A1W1I9B2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49521">
        <property type="protein sequence ID" value="SLM49521"/>
        <property type="gene ID" value="NSJP_3354"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3354"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="107" mass="12196" checksum="D22F2C0ACD965A4B" modified="2017-06-07" version="1">MTQPQAVQSHVKRLVITGCKVELIFRVEQGTHWSVQGIVECGTEGNRREQRFSTDRFDTMEAAEQEALRQAEHLLGHNEDRSTSRTKNWNETTQPGGRNADDRTVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9W1</accession>
    <name>A0A1W1I9W1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49786">
        <property type="protein sequence ID" value="SLM49786"/>
        <property type="gene ID" value="NSJP_3619"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3619"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="103" mass="11676" checksum="8508664B3196C64B" modified="2017-06-07" version="1">MLSRKDSPTPHEPFLHAVDVLSDRTEQRVRERKAAGPRSVSRRELEATMMDLMRHMRGTIGLHDLLLLTSIALSIPLRLAVPLAAQIVCSRINIRFPYCDQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9W5</accession>
    <name>A0A1W1I9W5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative tRNA (cytidine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.207</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (cytidine/uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yibK</name>
        <name evidence="4" type="ORF">NSJP_3502</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could methylate the ribose at the nucleotide 34 wobble position in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43088"/>
            <dbReference type="Rhea" id="RHEA-COMP:10333"/>
            <dbReference type="Rhea" id="RHEA-COMP:10334"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74508"/>
            <dbReference type="ChEBI" id="CHEBI:74511"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43084"/>
            <dbReference type="Rhea" id="RHEA-COMP:10331"/>
            <dbReference type="Rhea" id="RHEA-COMP:10332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.207" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3502"/>
    <dbReference type="EnsemblBacteria" id="SLM49669">
        <property type="protein sequence ID" value="SLM49669"/>
        <property type="gene ID" value="NSJP_3502"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3502"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18094">
        <property type="entry name" value="SpoU-like_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01885">
        <property type="entry name" value="tRNA_methyltr_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016914">
        <property type="entry name" value="tRNA_cyt/urid_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42971">
        <property type="entry name" value="PTHR42971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029256">
        <property type="entry name" value="SpoU_TrmH_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR029256-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="154" mass="17404" checksum="77C93CD716852FD3" modified="2017-06-07" version="1">MFDVILYEPEIPPNTGNIIRLCANTGARLHLVEPLGFSLEDRQLRRAGLDYHEWASISVHANWTECRARFEGRRLFAITTKGRQRYDAVKYVEGDAFLFGAETRGLPEPVLESVGESQRLRLPMMPDSRSLNLSNAVAVIVYEAWKQAGFHGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA00</accession>
    <name>A0A1W1IA00_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3648"/>
    <dbReference type="EnsemblBacteria" id="SLM49815">
        <property type="protein sequence ID" value="SLM49815"/>
        <property type="gene ID" value="NSJP_3648"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3648"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016584">
        <property type="entry name" value="MeTrfase_VrtF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011491">
        <property type="entry name" value="Mtase_YbcY_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_12" evidence="1">
        <location>
            <begin position="56"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="219" mass="24368" checksum="0531B0CD8682D42C" modified="2017-06-07" version="1">MSITAEQVEAGQAVYSKSTLAIYDWLVLRFSNRLIWTCPSARILALYDRHVTGNHLDVGVGTGYFLDRCRFPNDRKRLGLMDLNPTCLDAAATRVARYRPEVYRANVLDPIGLEIPRFDSVSMTYLLHCLPGTIKRKSAVFRHLKPLLNRGGVMFGATLLSKGVDKSWAARRLMAFYNSKGIFTNDGDDLQGLRSILSEHLNAVTVEVVGCAALFSGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA16</accession>
    <name>A0A1W1IA16_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="7">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NSJP_3697</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3697"/>
    <dbReference type="EnsemblBacteria" id="SLM49864">
        <property type="protein sequence ID" value="SLM49864"/>
        <property type="gene ID" value="NSJP_3697"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3697"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_1N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_binding_1" evidence="8">
        <location>
            <begin position="78"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="7">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM49864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="164" mass="18147" checksum="9DB2095A2C03A9CF" modified="2017-06-07" version="1">MLRYKHMETVVGRLKLVADEASLIAVLWPGDTPMRVRLEDMREDVRHPVLVEAGRQLSEYFQGRRTTFELPLLMRGTAFQKRVWQQLLRIPYGQTQSYGRLALAIGNGSASRAVGLANSKNPLSIVVPCHRVIGASGKLTGFAGGLDVKARLLELEGAQGRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA41</accession>
    <name>A0A1W1IA41_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49749">
        <property type="protein sequence ID" value="SLM49749"/>
        <property type="gene ID" value="NSJP_3582"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3582"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012484091" evidence="2">
        <location>
            <begin position="23"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="253" mass="26585" checksum="D2D275C7FA12038E" modified="2017-06-07" version="1">MRNVLALGAAVLLVGSVSVSMAQERLQSNQSGMGVGEGVGDVSGSSTRVTTFDRQQFLDRLSQPETVYGRILGIDIPGKKLHLESGGSSHDEGRAGAGSMVYRTVYLDDRTNMDQMRTIETGDDVMIMAVEETSANQPYGTGRKLVREVTVLRGNEKLAGFGGLGQRPNPMTERGINTNSGSVSGGPVGGVLPGTATGTVTTGVSEFTGAAPCWNCEPQPGWGYNTVAPETKMPNKSDYGTDVAKPNLVKGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA65</accession>
    <name>A0A1W1IA65_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase, ubiE family</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49882">
        <property type="protein sequence ID" value="SLM49882"/>
        <property type="gene ID" value="NSJP_3715"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3715"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="53"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="273" mass="29748" checksum="7D0C6CA130C302C8" modified="2017-06-07" version="1">MSNGILVAEGNQLKNRLKAMWMAGDYDRFSRYMESGAREFYERLSLAPGCRVLDVGCGSGQLALIAAKDGLDVTGVDIASNLIDRARARAQAEGLTARFEEGDAEALPFEDGSFDAVVSLIGAMFAPQPELVARELLRVCVPGGTIAMGNWTPQGFVGQMFKTISKFIAPSGMPSPVLWGEESVVRERLGAGLSDLSLTRRLYPFTYPFSPAEVVDVFRLYYGPTNRAFASLDAEGQERLRTELEALWASHNRAGAECTTVFAEYLEVVGIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA97</accession>
    <name>A0A1W1IA97_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49944">
        <property type="protein sequence ID" value="SLM49944"/>
        <property type="gene ID" value="NSJP_3777"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3777"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012167337" evidence="1">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="183" mass="20118" checksum="EC43FD2F8D2014DB" modified="2017-06-07" version="1">MRCPIVTTLVFGMMSLAGCAATIPVNYTAQNFARYEGRANVGSFQYVPANTGKVAPNQIQSTAIGSIYVAANVADLVQRATALELEKTGFRLGDNNPLVLSGDILEFQADDLGYSVDWSYSIRYKISRKADGSELLNKIYLADRKTTGKFGEASDYAPSINEMILSGYDKFIRDDQVRKIFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAD2</accession>
    <name>A0A1W1IAD2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3840"/>
    <dbReference type="EnsemblBacteria" id="SLM50007">
        <property type="protein sequence ID" value="SLM50007"/>
        <property type="gene ID" value="NSJP_3840"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3840"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008884">
        <property type="entry name" value="TylF_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40036">
        <property type="entry name" value="PTHR40036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05711">
        <property type="entry name" value="TylF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="284" mass="32413" checksum="38797E8EFEF9D44D" modified="2017-06-07" version="1">MQFPTTFSAATRLVDRTLIGLYHLLKGEHWLQYTPFQACGNYVKLRNTIQARDKLVMEEPLRSKYREALTYLADKYGPGSLGDYLEFGVYNGTSLTQMHRVLEDLGLEHVRLLGFDSFEGLPVEASYDDEGHWRPGSFKSEHAFTMQVLHWEKINFQRVVLTKGFFESTLTTDLRAKQHITKASVIMIDCDMYLSAKTALEFCAPLIVDETVIVFDDWFPLADRSLGEKRAFDEFLQAHPYFQAKEFGTYPPYGKIFVLARSSALEMHNSVAACASQPAFCSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAD3</accession>
    <name>A0A1W1IAD3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative VanZ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3785"/>
    <dbReference type="EnsemblBacteria" id="SLM49952">
        <property type="protein sequence ID" value="SLM49952"/>
        <property type="gene ID" value="NSJP_3785"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3785"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="501" mass="55267" checksum="DADE926C49CB9C52" modified="2017-06-07" version="1">MIVVGLLIAYVLYIVLFGLAPFTFSLGDADSFRSIYQDKFEGFSGISRVTLWDIWTNILYFIPCGFLIVLLPQTYSRGWRFKLLLISGVSVLLSGFVETAQVFLPRAPSVADILCNWLGGVVGGLAGVLFLAALPTLKASRWQRVWRRPVAGTMAGVYVVLLAVAIGMPLTVPRDFRNWNSSYRLFLGNEGTLDRPWQGAIYLAALYDRALTADAVWTNFSAGYGVDAHTKRIQEDLVFYYDFTEQHGTIVHDRSALRPPIDLQISEKAKYTWLSPNGLLFKGGSGASSLIAPQKLADMPLTYQKELSLETWVASGELNQGGPARIVSYSIDPYDRNFTLAQQNREIVFRLRTPVSGRNGAHPALTTVDSPLDRSVQHLVAVYRDGVTMLYVNGREHARMVVQQQLSVSDMLIRGLGETFKWLVYSVLIFPLGIASRFAFLELPHGPGRLLSLGLGLLGFFLAQGLRVLTFNAPLDPLLMLVGASTLAIAVVLLPSPSCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAK3</accession>
    <name>A0A1W1IAK3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50044">
        <property type="protein sequence ID" value="SLM50044"/>
        <property type="gene ID" value="NSJP_3877"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3877"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012845482" description="HMA domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="38"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="132" mass="13852" checksum="B64164E9C763DA29" modified="2017-06-07" version="1">MNRNGLQSRVKVQVLWLMLCCLSGWPLQNAQAGSPVHRISLQVGGPGCAIQQTVLSKTLLVLPGVMAVDWSLLPDHALIDLDARSITEQDLVAAAAQAAGPSCEVRPMASCISPMPAGSMTARPIESAGPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAL9</accession>
    <name>A0A1W1IAL9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_3646</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3646"/>
    <dbReference type="EnsemblBacteria" id="SLM49813">
        <property type="protein sequence ID" value="SLM49813"/>
        <property type="gene ID" value="NSJP_3646"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3646"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11567">
        <property type="entry name" value="YciH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005872">
        <property type="entry name" value="SUI1_arc_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="SSF55159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="63" mass="6572" checksum="F67E8E121A437EAC" modified="2017-06-07" version="1">MTVITGFVGISQSEKERLAKAMQKACGAGGTVKEGRIEIQGDHRDAVAHILSDAGFRPVFAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAR0</accession>
    <name>A0A1W1IAR0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3696"/>
    <dbReference type="EnsemblBacteria" id="SLM49863">
        <property type="protein sequence ID" value="SLM49863"/>
        <property type="gene ID" value="NSJP_3696"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3696"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="180" mass="20079" checksum="03DCC7814FB098A0" modified="2017-06-07" version="1">MMGGSGTGVTTLGLSVATRLKCACLDTEDFYWLPTTPPYREKRPVEDRIILIREKLESVQSSGCVLSGSLDGWGDPLIPLFDAVVFLAAPVHVRIERLRWREKERFGTEALAPGGAIHDQHEAFMEWAAAYDAGTMPGRSLPRHEQWLKRLPCPVRRLDGTKTIDELVQSVCRFLNGETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAS5</accession>
    <name>A0A1W1IAS5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3947"/>
    <dbReference type="EnsemblBacteria" id="SLM50114">
        <property type="protein sequence ID" value="SLM50114"/>
        <property type="gene ID" value="NSJP_3947"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3947"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="72"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="178" mass="20353" checksum="18EE5545A609987C" modified="2017-06-07" version="1">MQSKAIYVRISHFEEGQSHPMPSDYSKSQWWEGQVERRTQRRRSSECGRRQGVIEALPSVSYSPQVETSLATRIEAFVRVNLERGLTLKGLASFLGYSEKYSSEVFQLQMGTCFSHYVKGLRLLKAKRMLTGEETRVTRIAEALGFSDPFAFSHFFKRAVGCSPTAFRKQQLAQLDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAZ9</accession>
    <name>A0A1W1IAZ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4041"/>
    <dbReference type="EnsemblBacteria" id="SLM50208">
        <property type="protein sequence ID" value="SLM50208"/>
        <property type="gene ID" value="NSJP_4041"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4041"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="325" mass="37395" checksum="2F54808663380C30" modified="2017-06-07" version="1">MPRPLVSVIVPVHNCVDYLDQALRSVLDQDGPPIEVIVIDSSTKTSRGDVPAMADARVRRYSQEPRGVSAARNLGIQQARGEFIAFQDADDEWLPGKLRLQLQALEKYPEASLVFTDTMMFRDTTVIQPSMNQHMLKDWCQSHGPDLAGCYYGPLYPQLLVRDCMNTSAVVVRRSVLDLQGGFDENFKVGEDYDLWLRIARQYPMIFIDRVLTKYRVHAEGLSGGDDVRTLRWLEAHMAVRKKHQRMRWVPPQHAGLLTDILGERAWEAGWNYFGRNQLQDARRHFYIAMQSKPFVPKVWLYWCCSFLPCRVIETIRALRNAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB17</accession>
    <name>A0A1W1IB17_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative O-antigen polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_4025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4025"/>
    <dbReference type="EnsemblBacteria" id="SLM50192">
        <property type="protein sequence ID" value="SLM50192"/>
        <property type="gene ID" value="NSJP_4025"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4025"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="462" mass="50868" checksum="44485F2271A3B49E" modified="2017-06-07" version="1">MSGTLLAYGPDGFRESASATAWRPPAAFPRGSVAKAPDSKVGFYLVVLYMLFEFGRPQDILPGIKGIPFGTGISALILLKVLQSGKLNFSRLQTRLWIPLFVVMAIHVPLAVNNFWALMTFKDMFLLFCVYLGVITFVDTVGKMMTLMKFWMAIHVLLAAMGIAKGGIGIGAWMADENDFCMVMNMAAPFGYFLMFSANNMAQKLKYLGCLGAFLLAAMASLSRGGFIGLASVGSYCWYRSPKKMNALVVLLVAIVFMVLLAPETYWDEIASSTSDETIDKGTGAERLYTWGIGMEMFLHNPIIGIGQSNFPWTFDSYQEGRTFQGRSIAGRQAHSAWVTLIAELGIAGIVIIGMMLLQCYRDLKLVRTRFAPPNSRLKHGVTVHPGEDVRVYFARAMEGSLIGFIVSGVFISILWYPSLWIMMSFVVALRNIADNDQGAQVAPPDPVPVSRRLPFLTTARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB85</accession>
    <name>A0A1W1IB85_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NSJP_4099</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4099"/>
    <dbReference type="EnsemblBacteria" id="SLM50266">
        <property type="protein sequence ID" value="SLM50266"/>
        <property type="gene ID" value="NSJP_4099"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4099"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="82"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM50266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="476" mass="51354" checksum="6782EE294D068D8B" modified="2017-06-07" version="1">MTWLATVLPTGGDRLRRALVVVVLFSILSKLMLGALVFSLNPDGIFESSDAHEYHQLALNMARYGTFSRSVNPPLDPEIIRTPAYPLLLAGLYQVVGIRPHAVIPVQIALSVVTLLAGFRIACLLFGPRAGLLTAVFLALDPVSMYYSQVMLTETLFGTALTLCLLGMVQAIRIPSPRYPSWAGVCLAAATYIRPTGYYLGLLLPMVLFLAIQRSGGWRRALASAALMGIIFFVLVGGWQVRNYVATGSTAFSQAKNQYLLIAKAAAIVAMRDGVSLQEAQQRLADEHAASLPPKFFPASQALLLESQGQFAQSVIAAHPVLLVVTTSRGMAANLLGPSNMAHLLGSDNVALRDAFLQRDFARFPPSYWMAALSSWTVGVLFLGIVYGGVVLLFKRKGFRNGDIALLVLTAVYVILVSSGPEAYSRFRMPIMPILCVLAAGGYLCRGVIELGECDDIPRGALERAVDAGHAARRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBE5</accession>
    <name>A0A1W1IBE5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_4159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4159"/>
    <dbReference type="EnsemblBacteria" id="SLM50326">
        <property type="protein sequence ID" value="SLM50326"/>
        <property type="gene ID" value="NSJP_4159"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4159"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="60"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="592"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM50326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="628" mass="70690" checksum="E6AD328FFA3296B6" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBF9</accession>
    <name>A0A1W1IBF9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4148"/>
    <dbReference type="EnsemblBacteria" id="SLM50315">
        <property type="protein sequence ID" value="SLM50315"/>
        <property type="gene ID" value="NSJP_4148"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4148"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="22"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="386" mass="42427" checksum="2E91A3B8A9D383D3" modified="2017-06-07" version="1">MLPQAVERPVQWLFLTRSLTCGGSQRQLVELVRSLAQRNAPVAVATLYDGGPMRAELQGTAAPVFSLAKQTRWDLVRCLARLVKLVRRMRPMVVHGYLGTANILALLAKIAAPSVTVVWGIRASNMDLRRYGWLDRTLYRLESRLSRFSDLIIVNSERGWEYAVAQGFPAEKMLCIPNGIDTERFKPDAEAGRRFRRRQRVGEDIPLIGLVGRIDPMKGHRTFLEAAAALIAAGGNARFVCVGNGEARRKKELRAQSERLGVAGLVTWLDEHDPIEEVYNGLDLLTSCSSYGEGFSNVVAEAMACGCPCVVTDVGDAGRIVGETGCIVTPDRSDEVVAAWEKLLSFSCSERANVGHAARDRIVRHFGLDRLVEASFSALTLAGSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZI5</accession>
    <name>A0A1W1HZI5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipopolysaccharide core biosynthesis glycosyltransferase KdtX</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">kdtX</name>
        <name evidence="3" type="ORF">NSJP_0006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46178">
        <property type="protein sequence ID" value="SLM46178"/>
        <property type="gene ID" value="NSJP_0006"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0006"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="271" mass="31664" checksum="78F90CB7E26B040A" modified="2017-06-07" version="1">MAGYSVYVIAYNDEPNMRACLESVAWADELIVVDSHSTDRTAAIAREFTDKVYQVEFNGFGRLRNQAVAHCSHEWVFSLDSDERMTPELREEIQRLLDQRPEADAYFVPRKNYFLGRWIEHCGWYPDYRQPQLFRKNRFRYREELVHESFECDGPVAHLTQPALQYPFRDLDHYIQKQNRYSTLMAERMVEQGRRFSILQLFTHPFGAFAKMYVQRRGFLDGMPGLILSGLYAYYTVMKYAKFWELTDGPTSTRSSAPRAASSGNRPGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZL4</accession>
    <name>A0A1W1HZL4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipopolysaccharide heptosyltransferase II and D, D-heptose 1,7-bisphosphate phosphatase (Modular protein)</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
            <ecNumber evidence="3">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gmhB</name>
        <name evidence="3" type="ORF">NSJP_0009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EC" id="3.1.3.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0009"/>
    <dbReference type="EnsemblBacteria" id="SLM46181">
        <property type="protein sequence ID" value="SLM46181"/>
        <property type="gene ID" value="NSJP_0009"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0009"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011910">
        <property type="entry name" value="RfaF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02195">
        <property type="entry name" value="heptsyl_trn_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="575" mass="61859" checksum="DE2F2D19EA3EE55A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZM4</accession>
    <name>A0A1W1HZM4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46210">
        <property type="protein sequence ID" value="SLM46210"/>
        <property type="gene ID" value="NSJP_0038"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0038"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="68" mass="7302" checksum="E76BEA73D2AD68F0" modified="2017-06-07" version="1">MAFDPANPPIWLRKLHVTAAQISPDDYPSTPEEGILECCRLSDAHMALSKAFAAALFSESSGAEAEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZN8</accession>
    <name>A0A1W1HZN8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46211">
        <property type="protein sequence ID" value="SLM46211"/>
        <property type="gene ID" value="NSJP_0039"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0039"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018700">
        <property type="entry name" value="DUF2204"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09970">
        <property type="entry name" value="DUF2204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="208" mass="23086" checksum="B3AD44DDE39DDEC0" modified="2017-06-07" version="1">MDTDEPSLKPNWSLPSDLLSFLANAQTILSKASIPHCLIGGAALGAWGRPRATNDLDLLVLVDDESRTRLITQLSLSDIRVNQRWLDANPMAKARVTRFAAPSCPDYPLDIIYAADRHEHETLARAQRVLLQGLSLTVVSPEDLILLKLKASRPTDFDDVLAIVKNPRLQLDLAYLWDWVDRLGLQGELQYVFQAATGEEHGSGQQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZQ4</accession>
    <name>A0A1W1HZQ4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="2">TMP kinase</shortName>
            <shortName evidence="2">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="2">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">thiL</name>
        <name evidence="5" type="ORF">NSJP_0025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0025"/>
    <dbReference type="EnsemblBacteria" id="SLM46197">
        <property type="protein sequence ID" value="SLM46197"/>
        <property type="gene ID" value="NSJP_0025"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0025"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="3">
        <location>
            <begin position="39"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="164"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="353" mass="37859" checksum="EFB7DBB52430011C" modified="2017-06-07" version="1">MTPPALHKARVPLREFDLIRSLRRLCAGRDASLKRGIGDDTAVTAGPPGLDLLLTTDLLAERIHFDRRTADLSDIGFRSAAANLSDIAAMGGDPKYLLIALALPNGATARHVGELYRGIMAACRPHRVLVIGGDTSASAGGWFVGVTAVGTVERGRALLRSGAKVGDAIYVTGTLGDSLAGLALANERPGRRSRTAILSTRQRQFLLKRHLRPDARVTVGRWLVRERLATAAIDLSDGLSGDIRHLCEESKVGAEIDRASLPLSQAGLAYAKSTGSDPATMAATGGEDYELLFTTPIRLCGKLERAARRKGFRLTKIGTIKPARFGIQARWADGLKPLPVTSYRHFQSPRGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZR2</accession>
    <name>A0A1W1HZR2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0035"/>
    <dbReference type="EnsemblBacteria" id="SLM46207">
        <property type="protein sequence ID" value="SLM46207"/>
        <property type="gene ID" value="NSJP_0035"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0035"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012664277" evidence="1">
        <location>
            <begin position="22"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="249" mass="27424" checksum="B5C116CA40308A99" modified="2017-06-07" version="1">MFIAKRIPFLFLAAVSCVAVTAIGQAEQWDGPDNLTGTLSRSGHVTVGEQIQAEGPKALLEVTRPLGASDDRNDRLFSANNLYKGATGVRFEVDTRHAYAGAARGKIDILPADMDFAVHRKAAIGVSTINERLPGDYTLIVGGKILAEEVRIKLIKDWSDYVFNTDYALKPLPEVERFIHTHRHLPAIPSSAEVEQDGINLGHMQAKLLQKVEELTLYVIEQHKAIEVLQRKLTEVERVNALPDAAAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZW2</accession>
    <name>A0A1W1HZW2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable molybdenum cofactor guanylyltransferase</fullName>
            <shortName evidence="4">MoCo guanylyltransferase</shortName>
            <ecNumber evidence="4">2.7.7.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GTP:molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Mo-MPT guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin-guanine dinucleotide synthase</fullName>
            <shortName evidence="4">MGD synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">mobA</name>
        <name evidence="6" type="ORF">NSJP_0128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide</text>
            <dbReference type="Rhea" id="RHEA:34243"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:71310"/>
            <dbReference type="EC" id="2.7.7.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MobA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.77" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0128"/>
    <dbReference type="EnsemblBacteria" id="SLM46300">
        <property type="protein sequence ID" value="SLM46300"/>
        <property type="gene ID" value="NSJP_0128"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0128"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061603">
        <property type="term" value="F:molybdenum cofactor guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00316">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="5">
        <location>
            <begin position="7"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="202" mass="22400" checksum="4B953C57AEEFDA6A" modified="2017-06-07" version="1">MITEVTGILLAGGKSRRMGEDKRFVEIGARSLLERSLDILRCVFQDVVIVIAQDSPDLSSTVPVVRDLVADCGSLGGLYTGLSVARTNRVFVLACDMPFLSQETVRYFVHLKTEADIVMARLHNGWHPMHALYGRRCLPVMESMMAAKDLRIHRVTEHPALKLHTVTAEDLKTIDPAGRAFLNINTPADLELARSIFASDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0A8</accession>
    <name>A0A1W1I0A8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR_21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_0268</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0268"/>
    <dbReference type="EnsemblBacteria" id="SLM46440">
        <property type="protein sequence ID" value="SLM46440"/>
        <property type="gene ID" value="NSJP_0268"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0268"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018704">
        <property type="entry name" value="TPR_21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09976">
        <property type="entry name" value="TPR_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="TPR_21" evidence="4">
        <location>
            <begin position="39"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="268" mass="29754" checksum="5F4B6F964C7D8506" modified="2017-06-07" version="1">MSYRIKVPTRTLEVDEAHLVSGLEHALIRLQDYRKPLLVGLGVLILAVLVVGGVFWFDRQASQKAQELEREATRLYMTRPVADPAKSDAALKGAIEKYRQVVDEYPRTSSAPLALFHLGNAQMQANDQPGAIETYQRFIMQYSSQTTLVGLARQRLAYAYLLKGDREQAVKTFTSIVESGGALNKDQALFELARLEEAQSRPEGALAHYQELIKSYPASPYTNEAMVRTKMLDTKHQTEPSSAAPAASTKPPAPQSEPIKPDAVKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0R5</accession>
    <name>A0A1W1I0R5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH-quinone oxidoreductase subunit F 2</fullName>
            <ecNumber evidence="13">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nuoF</name>
        <name evidence="13" type="ORF">NSJP_0409</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="13"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0409"/>
    <dbReference type="EnsemblBacteria" id="SLM46581">
        <property type="protein sequence ID" value="SLM46581"/>
        <property type="gene ID" value="NSJP_0409"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0409"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="12">
        <location>
            <begin position="330"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM46581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="433" mass="47404" checksum="696EBC2851053A83" modified="2017-06-07" version="1">MVTLTEPRVLQKLDGPPWDIDAYLKVGGYEAWKKCVRELSPEQVVQELKASGLRGRGGAGFPTGVKWDKVLNHRVKEHYFVCNAGEHEPGTFKDRHLLKTAPHQLIEGCLIASHTAQAKASFIYVNHEYEEERENLKRALAQAKERGFVGKNILGSGIDIDLQVFEGHGSYVAGEETAMLESMQGRPAMPRQKPPFYPTDFGLYGKPTLVNNVETLCNIPRILYKGAQWFTQVGTEKCPGTMMFSLSGAVNRPGVYEMPMGITIRQLIETCGGGVPGGRKIKAVFPGGPAFSMITADQLDLAMDFDSLKKAGTGLGSAGVIVVDDATCMVRQTLKFSNFFKGESCGQCPPCRMGTINLANLMTKIEAGEGTQKDLDSLLQLCGFVKGTGYCTLVTGASVLVQSSVKLFRHEFEEHIRLHRCPYPAAPVDTTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0X0</accession>
    <name>A0A1W1I0X0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Divalent-cation tolerance protein CutA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0473"/>
    <dbReference type="EnsemblBacteria" id="SLM46645">
        <property type="protein sequence ID" value="SLM46645"/>
        <property type="gene ID" value="NSJP_0473"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0473"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="PTHR23419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="91" mass="10290" checksum="306EE82EB88669C8" modified="2017-06-07" version="1">MSKTLVSKRLVACATIIGKAQSFYEWKGKMVQDSEVLIIMKTTARRYPALERAIKALHPYEVPEIIGLSVKSGFAPYLAWIFTQVDQSKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0X9</accession>
    <name>A0A1W1I0X9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="11">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">rlmN</name>
        <name evidence="13" type="ORF">NSJP_0486</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="11"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0486"/>
    <dbReference type="EnsemblBacteria" id="SLM46658">
        <property type="protein sequence ID" value="SLM46658"/>
        <property type="gene ID" value="NSJP_0486"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0486"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="85"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="148"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="202"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="11">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM46658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="344" mass="37819" checksum="7F54B11E8479C34A" modified="2017-06-07" version="1">MVEVVGQLGWPAYRAGQILRWLYQRRSTSVDQMTDLSRADRSTLRSATVIRRATACTVFRAADDTRKLVLTLEDGLNVEAVLIPDDDRLTLCVSTQVGCTLDCGFCLTGTMGLKRNLKPDEILDQVLTAQDQLGKSERITNLVFMGMGEPLANFENLADALARLTNRTWGLGFSPRRITVSTAGLASRLKDLAPLGVNLAISLNASTEVQRQRLMPAANGIASLRSLLAACRRYPLHPGRLLTFEYVVLAGVNDQIDDARRLTKLLRGLRYKINLIPFNEFPGSTFRRPADATVLAFQSVLKQGGIDVFIRKSRGRDVLGACGQLGNIQPSRGEAALTQIESRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I101</accession>
    <name>A0A1W1I101_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="7">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_0514</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0514"/>
    <dbReference type="EnsemblBacteria" id="SLM46686">
        <property type="protein sequence ID" value="SLM46686"/>
        <property type="gene ID" value="NSJP_0514"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0514"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="6">
        <location>
            <begin position="14"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Dus" evidence="6">
        <location>
            <begin position="172"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="397" mass="43618" checksum="86606FD256F36E36" modified="2017-06-07" version="1">MSFWLSLPRPILGLSPMDGVTDAAFRHMVASHGKPDVLYTEFTHVHDVCRGPEFLLDSLMYGELERPIVAQLYGKDPELFYQAAHAICELGFDGLDINMGCPSRNVASSGSGAGLIKTPDLARQVMRAARRGIEDWAAGQSLESAGIKSARAEIIRRLSDRCRSASTIHRRTIPLSVKTRLGYDAVIVDRWIEHLLLERPAVISLHGRTLQQMYRGQADWHAIARAAEVVRGTDTLLFGNGDVHSLAEAACRVRETGVDGVLIGRGALGAPWLFRDKEAVRRASLVAGLDPQPAPQLWTPPFSVRFDLMLEHASWFERQWGADRFRNMRKHLGWYCKGFPGAAALRAAMFQVSSLADVKAALAAHLDRASAVRSAGVEVLTDDTEVEEAVSLASRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I134</accession>
    <name>A0A1W1I134_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster insertion protein ErpA 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">erpA</name>
        <name evidence="2" type="ORF">NSJP_0407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0407"/>
    <dbReference type="EnsemblBacteria" id="SLM46579">
        <property type="protein sequence ID" value="SLM46579"/>
        <property type="gene ID" value="NSJP_0407"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0407"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
        <location>
            <begin position="2"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="106" mass="11375" checksum="D37BC6572C1F815F" modified="2017-06-07" version="1">MVTITAVAEQKIQELMKEEKDIVGLRIYVRGGGCHGYQYGMAFESKMAEDDTVIEKGDVKVIMDSQSAPLLQGAEVDYVDSVQGSGFSIKNPQAKTTCGCGSSFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I161</accession>
    <name>A0A1W1I161_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46721">
        <property type="protein sequence ID" value="SLM46721"/>
        <property type="gene ID" value="NSJP_0549"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0549"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="47"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="282" mass="32016" checksum="B035D1587E9B0DA3" modified="2017-06-07" version="1">MKFGAFELYPVSDGRFRLDGGAMFGVVPKVLWDKCCHADELNRIPLSLTCLLIRAHGKNILLDTGLGSKEDDKFHRMFAIERTPTLLDSLKRWGVEPEDVDLVINTHLHFDHAGGNSRRRANGTLSPTFPKARYVIQRGEYDDASRANERTKASYRLANFAPIAEAHQWEFLDGDTEVVPGVTALVTAGHTRCHQGIKIESEGHAAFYLGDLIPTVSHLPLPYIMGYDLFPVQTLETKRWVLDRAFEEHWLLLFEHDPLIQAGHVKRDLEGKYFLQEVNAWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I162</accession>
    <name>A0A1W1I162_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Ferredoxin reductase</fullName>
            <ecNumber evidence="2">1.18.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.18.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0568"/>
    <dbReference type="EnsemblBacteria" id="SLM46740">
        <property type="protein sequence ID" value="SLM46740"/>
        <property type="gene ID" value="NSJP_0568"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0568"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="234" mass="25945" checksum="C9E9C634EAE41052" modified="2017-06-07" version="1">MAEFTQWATLLSVTNLTPHVRQLVLLPKERPLSFAPGQWVSLKLPVGPNPPLNRAYSMAAPGTASGELTLILDRVTDGLGSGYLYGLSPGNAIQLSGPYGNFTLPSQLDRELLFIGRFTGLVPIRCMLKQMYAHHRMDSVLLIAVAPDEDDLLFHHEFLTLAIHHPGFRYLPLVAAGGEQQAVDLVLSMLRPLMNGGPQMLPMLCGTKQFVRPLRAYFVESGYERKEVKTETYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I193</accession>
    <name>A0A1W1I193_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46751">
        <property type="protein sequence ID" value="SLM46751"/>
        <property type="gene ID" value="NSJP_0579"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0579"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="249" mass="28034" checksum="BE91C0206AC134C1" modified="2017-06-07" version="1">MRIKKKGPKPSSKRPPLYFVGYRGSVPGIEELKTWYDLEYHGPLSVKPEEDAPESWRLSHGPWTAHVVIPLPATHQAGLKDQLAWEHESMGVVAPSITSPREMPDSVLFAARVARGLTLLTQGTAHDPATRQYLNPSDWKDRTLVEFVIDDHVTIAQDDEARPDHTWWYTLGLAKFGMDELETFRPKGLSDQRSNELLAESAHEMIRIGVSPKVGTAFHLPMIGRTIRVTNHRTAAPTGRMQSFREITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I194</accession>
    <name>A0A1W1I194_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hybrid sensor histidine kinase</fullName>
            <ecNumber evidence="5">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_0582</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0582"/>
    <dbReference type="EnsemblBacteria" id="SLM46754">
        <property type="protein sequence ID" value="SLM46754"/>
        <property type="gene ID" value="NSJP_0582"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0582"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="137"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="380"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="501" mass="54872" checksum="DF614FEFC6509CFC" modified="2017-06-07" version="1">MSSSEHPRYDARALLNSQPVSVAVINPATYRVEFQNETGLKTFGDIAGKVCYEKIASCVSPCSFCRMSEALATDSVVSQEVALPGDKHLLIHWSKVAAADGPTHVIETIVDITEHKRTEHALRQSQKLEAVGRLAGGIAHDFNNLMMVVIGHAHRVLQQLGGHPARQELERISQAGMRAAALTKKLLTFSRQQVFEPKELPVNQVIREMEDILRQLIGEQIQTVVVLHPHTGHALVDPVQLGQVVMNLVLNARDAMPDGGLLNIETDNAELDEEFARLHPGARRGSYVKIVVRDAGCGMSAETMSRIFEPFFTTKGPDKGTGLGLATAYGIVKQSQGYIEVTSELGRGSRFCVYFPRVGQPVMEAPPQKKETHASAAQEMILVVEDEESIRKLVAAILQDQGYHVLSAVDGIEALQRLQTLKGRCDLIITDVIMPRMKSAAFVEGVKAMRPETRVLYMSGYAGDTLQVNGVAEGVPFLQKPFLPNTLIEKVHELLQAGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I198</accession>
    <name>A0A1W1I198_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0603"/>
    <dbReference type="EnsemblBacteria" id="SLM46775">
        <property type="protein sequence ID" value="SLM46775"/>
        <property type="gene ID" value="NSJP_0603"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0603"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="313" mass="35647" checksum="1F42CEB3F10A12C2" modified="2017-06-07" version="1">MASRYRKIDPRIWTDEKFRRLTAEEQRIALYILTAQSNRIGLFSFSPGKASEDLETLPPTFLERFGNVCRTLNWEWDADARVLFLPTWWRYNQPENANNVIGNLKDLDDLPETPLLKRFSANTAYLPEGLIGTFTQTLAKRYPQRYPKRSPSQEQEQEQEQKQEPPPAEHQAFGEFWNLYPTRNGKKLGRTDALKKFCRLTPTDQTLLLTAVKNYASSGDVVQGVGIADPHRWIQKGTGKTQVEPWRDWIEPAPSAIANGHSHLGVCTKRIHHPGSQVLRACGEPASPVSRPDEPRCQAHLSSVIDAHEVMHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1I6</accession>
    <name>A0A1W1I1I6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M78 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0698"/>
    <dbReference type="EnsemblBacteria" id="SLM46870">
        <property type="protein sequence ID" value="SLM46870"/>
        <property type="gene ID" value="NSJP_0698"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0698"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M78" evidence="1">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="81" mass="9769" checksum="A98CB70A7300531A" modified="2017-06-07" version="1">MRIPSRVVFPFGYRISVRQLSDSEMDRRDPNADGIWDDELKIIYLRKRLPVTRRRYILAHELGHAWLDWQHRHLDNGKAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1M0</accession>
    <name>A0A1W1I1M0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LAB_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0715"/>
    <dbReference type="EnsemblBacteria" id="SLM46887">
        <property type="protein sequence ID" value="SLM46887"/>
        <property type="gene ID" value="NSJP_0715"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0715"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008915">
        <property type="term" value="F:lipid-A-disaccharide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011499">
        <property type="entry name" value="Lipid_A_biosynth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014546">
        <property type="entry name" value="UCP028440_lipidA_biosyn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07578">
        <property type="entry name" value="LAB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028440">
        <property type="entry name" value="UCP_LAB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01259">
        <property type="entry name" value="LAB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="LAB_N" evidence="2">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="101" mass="11193" checksum="232647DE468BB706" modified="2017-06-07" version="1">MSNAEVIWIAIGFLGQGLFFGRWVVQWIASERTAKSQVPIAFWYMSLIGGMITLAYAIYRKDPVFIAGQGVGSVVYVRNLMLIHRSSQDQTAQHPSSVGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1N9</accession>
    <name>A0A1W1I1N9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative TrmH family tRNA/rRNA methyltransferase YacO</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yacO</name>
        <name evidence="2" type="ORF">NSJP_0740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0740"/>
    <dbReference type="EnsemblBacteria" id="SLM46912">
        <property type="protein sequence ID" value="SLM46912"/>
        <property type="gene ID" value="NSJP_0740"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0740"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="13"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="261" mass="28152" checksum="6173E75A65CB7ADE" modified="2017-06-07" version="1">MVPADGNDEPSELLYGLHAVREALRAGVRPIQRLLVLRQDRQFGDVVQRAKEKRIPVQLGPAAAFDRLVPGGKHQGVIAFVAAKAYVALDEILESARARNEPPFLLLLDGVEDPHNLGAVLRTAEAAGVHGICIPERRAVGLTSVVAKVSAGAIDHMPVSRASNLTRCIEDLKKAGIWVYGVEPSAEKIYTETDLTGPLAIVVGGEGEGIRPGVRKECDELLRIPMMGKVESLNVSAAVSVVLFEAVRQRNRKRMAVPTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Q8</accession>
    <name>A0A1W1I1Q8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46946">
        <property type="protein sequence ID" value="SLM46946"/>
        <property type="gene ID" value="NSJP_0774"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0774"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="63" mass="7050" checksum="39B2BE2EBF3B36E5" modified="2017-06-07" version="1">MIPQKSGAESATDGWNLKFILFRHLNFDSEGPVACIRATGPPCLALVWPIVSRDLIDFRPPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1V2</accession>
    <name>A0A1W1I1V2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Hydrolase, HAD-superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0803"/>
    <dbReference type="EnsemblBacteria" id="SLM46975">
        <property type="protein sequence ID" value="SLM46975"/>
        <property type="gene ID" value="NSJP_0803"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0803"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="234" mass="25114" checksum="E6A7D567CC3AF1CD" modified="2017-06-07" version="1">MTPDARQAIGAIIFDFNGVLADDETPHVLCFQQALAEFGLSLTVEDYYGTYLGMDERTCTATLLRASGDAGDRRLLDRIIARKAQLFALRTADDQLPLFPGAADFVKAARSGYRLAVASGGRRHQIDRAIHGTAIEEIFDVIVAADDCPIGKPDPAIYRMTLARLNDGARTPSLSASNCLVIEDSLAGIRSARQAGMKVLAVASTYPAERLREADGVLAGFVGLTPEEAVRMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Y7</accession>
    <name>A0A1W1I1Y7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Orotate phosphoribosyltransferase (Modular protein)</fullName>
            <ecNumber evidence="2">2.4.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.10" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0830"/>
    <dbReference type="EnsemblBacteria" id="SLM47002">
        <property type="protein sequence ID" value="SLM47002"/>
        <property type="gene ID" value="NSJP_0830"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0830"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021383">
        <property type="entry name" value="DUF3015"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11220">
        <property type="entry name" value="DUF3015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012461441" evidence="1">
        <location>
            <begin position="17"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="175" mass="18608" checksum="CEB3A19FF804F4D4" modified="2017-06-07" version="1">MSRKIWVLLIAFFVTAELSGMIDTAQAKGISDLGPGCGLGKDLWRDSPNTDKWGVQILISTTNNTIVPFQAFGITSQTMGCKNSGKFWAEHKANMFAGLNFENLTQEMAQGGGEHLASMAALMGVSEDKQPEFFAVTQERYLSLVNAGEASPVAMVKALNEAAASSPASTTVAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I202</accession>
    <name>A0A1W1I202_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rpsT</name>
        <name evidence="9" type="ORF">NSJP_0866</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0866"/>
    <dbReference type="EnsemblBacteria" id="SLM47038">
        <property type="protein sequence ID" value="SLM47038"/>
        <property type="gene ID" value="NSJP_0866"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0866"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="92" mass="9938" checksum="D84639F8339436B3" modified="2017-06-07" version="1">MPVIHKSTIRRARQAEKRRARNHAALSIVKGLVKKVQTAVAEKKAEDAKSSLRAAEAALSKAVTKGILKANTASRRISRLTIRVNALGATRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2M2</accession>
    <name>A0A1W1I2M2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Sulfite:cytochrome c oxidoreductase, subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_1094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1094"/>
    <dbReference type="EnsemblBacteria" id="SLM47266">
        <property type="protein sequence ID" value="SLM47266"/>
        <property type="gene ID" value="NSJP_1094"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1094"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008168">
        <property type="entry name" value="Cyt_C_IC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00605">
        <property type="entry name" value="CYTCHROMECIC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013229780" evidence="5">
        <location>
            <begin position="22"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="130"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="207" mass="22539" checksum="115FAAB4BBEFF2B1" modified="2017-06-07" version="1">MTRNKRRAAWFVMIAGFAAFTAVIRAQEDDGYSIAVALAPRAEGLIVARCTVCHSEELIAQQRLPRERWVAIVEKMNHWGAQISRDEADLLVRYLSARYHPGAPERLAPIELGAAEPLTQETRTDGPLVGVAQRGAGIFELNCQACHGAGAGGGMGPKLAGNPILKHEDLFWETVLHGRGPMPAWSSVLSQQDIADVHAWLSAREPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2M3</accession>
    <name>A0A1W1I2M3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_1088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47260">
        <property type="protein sequence ID" value="SLM47260"/>
        <property type="gene ID" value="NSJP_1088"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1088"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010724406" evidence="5">
        <location>
            <begin position="35"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="49"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="154" mass="16465" checksum="7DD61BB693510978" modified="2017-06-07" version="1">MKQARTANRLHRVQRVVRLLVLGAAVLCFASAQPASGGAGPGSTERAAGQAQAGKAVFNGKGVCFYCHGVDGRRDRLPRIEADTAALIAQLNPPPADLRVPSRLRLKTDRERTSAIRNGHPGTGMFPDTRITDQELADTLAYLAVLRQEGTPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2N8</accession>
    <name>A0A1W1I2N8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_1104</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1104"/>
    <dbReference type="EnsemblBacteria" id="SLM47276">
        <property type="protein sequence ID" value="SLM47276"/>
        <property type="gene ID" value="NSJP_1104"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1104"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="384" mass="43024" checksum="7227B7F59E0AE8DF" modified="2017-06-07" version="1">MNLRRVRAVAVKEWKETTRDRLFLGLAFLMPVLWLVVFGYGLVMDVENIPFAVIDHDHSQMSRDYIYRFMQSRYFSYRGHVADMQDLDRLLTETKIRAAIIVPERFQEQLSGGETVSVQTFLDGTFPLQTDIAKGYIVAINQAFGEDLVSEYVSKLRGVARAEARRAVRPIALEIRYLYNEEVRSSWSTVPALVMFTLMLASPLLTALGIVREKETGSIYNIYSSTVSRTEFLAGKLLPYIAISLFNVGMLWLMAVLLFQVPFKGSLLFFYSASVFFVLCTTGIGLLISLLVQTQMAALIITMVVAILPTILFSGLLVPVASLSRGARVQAHIFPGMFYTDIVRGSFLKGVGLDVLWPDVGALAIFAVVIGLITYHLFSKRPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Q3</accession>
    <name>A0A1W1I2Q3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trehalose 6-phosphate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">otsB</name>
        <name evidence="5" type="ORF">NSJP_1118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Removes the phosphate from trehalose 6-phosphate to produce free trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="EC" id="3.1.3.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the trehalose phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.12" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1118"/>
    <dbReference type="EnsemblBacteria" id="SLM47290">
        <property type="protein sequence ID" value="SLM47290"/>
        <property type="gene ID" value="NSJP_1118"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1118"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044651">
        <property type="entry name" value="OTSB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43768">
        <property type="entry name" value="PTHR43768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="276" mass="29916" checksum="FBFE3EFAFC89ACF3" modified="2017-06-07" version="1">MIHLLSEEGRRALGALAGRPLLYAFDFDGTLAPISADRDGVTLPRETGGWLTELAKRTTCAIISGRSVADLARRVNGSVPHLIGNHGIESPLSSPTTLRLAEEVCEHWRRELANEQSDSMAAAGGEIEDKRYTLTIHFRCAPDPAAACRRALQILNRLTPAPSLIMGKHSINVLPPGQSGKGSAASALMTHLRRDGLFYIGDDETDETVFSLNEGLVMGVRVGAENGSRARFYLDHQTEVQDVLKLLTHHLDLTPTFQDSHSPGRAGSIHELSRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2R0</accession>
    <name>A0A1W1I2R0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47284">
        <property type="protein sequence ID" value="SLM47284"/>
        <property type="gene ID" value="NSJP_1112"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1112"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="88" mass="9982" checksum="954B026D371F6A21" modified="2017-06-07" version="1">MYRLSGQDHIIQALDSQRLSSEQRQEDDRHIYCAMSGALVKARVIRTGLRMTLLRKKEAFTSSILFPVVGRRSLGGRCSDYMEPGVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2V1</accession>
    <name>A0A1W1I2V1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1150"/>
    <dbReference type="EnsemblBacteria" id="SLM47322">
        <property type="protein sequence ID" value="SLM47322"/>
        <property type="gene ID" value="NSJP_1150"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1150"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="355" mass="39279" checksum="1E7AFC891BD1D9FB" modified="2017-06-07" version="1">MTGNHRSEVVVVTGASAGVGRAIARRFGAQGASVVLLARGLDGLEGARADVEQAGGRALVIPTDVSDDRQVEAAAEQAERTFGPIDVWINNAMVSVLSPALDMTSGEYRRVTDVTYLGYVFGTLAALRRMVPRDRGVVIQIGSALAYRAIPLQSAYCAAKHAIQGFTESLRSELLHEGSRVRLTAVQLPAVNTPQFSWIRTRMPRHPRPVPPIYQPEVIAEAIYWVSHHHRREFAIGYPTVQAIVGDKFIPGLLDHYLAHVGYESQQTDVPVDPDRRDNLYEPLPGDYGARGRFSEQACDYSAQVWANRHRGWLAAGGVGLLAWWWSRRYGSRRRQAQGRSAARLRRPVKPVWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Z3</accession>
    <name>A0A1W1I2Z3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Histidine kinase</fullName>
            <ecNumber evidence="6">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47364">
        <property type="protein sequence ID" value="SLM47364"/>
        <property type="gene ID" value="NSJP_1192"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1192"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <end position="30"/>
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            <begin position="1137"/>
            <end position="1354"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SLM47364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1356" mass="152987" checksum="8CA6A5293B6AFA49" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I309</accession>
    <name>A0A1W1I309_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="SLM47382"/>
        <property type="gene ID" value="NSJP_1210"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1210"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020311">
        <property type="entry name" value="Uncharacterised_Rv0898c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10944">
        <property type="entry name" value="DUF2630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="77" mass="9033" checksum="E1BA49DC2F55F2A5" modified="2017-06-07" version="1">MSDSSVLSQIETLVLQQHLMQGKESLSEDEFLRLRRIQVEIDQCWDLLRQRRALRSVGQDPDRAQVRPAEIVAKYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I395</accession>
    <name>A0A1W1I395_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-quinone oxidoreductase, membrane subunit M</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoM</name>
        <name evidence="6" type="ORF">NSJP_1300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
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    <dbReference type="EC" id="1.6.5.11" evidence="6"/>
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        <property type="protein sequence ID" value="SLM47472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
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        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
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        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
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    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
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    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="422"/>
            <end position="443"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="5">
        <location>
            <begin position="134"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="519" mass="57149" checksum="FC39277C43E99ECF" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I397</accession>
    <name>A0A1W1I397_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit B</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">nuoB</name>
        <name evidence="4" type="ORF">NSJP_1308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1308"/>
    <dbReference type="EnsemblBacteria" id="SLM47480">
        <property type="protein sequence ID" value="SLM47480"/>
        <property type="gene ID" value="NSJP_1308"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1308"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1 2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="3">
        <location>
            <begin position="44"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="175" mass="19450" checksum="0AFADB9706BC9082" modified="2017-06-07" version="1">MGLIQLGRQEKDGAPDVITTTVEKAVNWARKGSLWPMTFGLACCAIEMIAAVSSRYDMDRYGAGVFRASPRQSDLMIVAGTVCRRMAPVIRKIYDQMPEPKYVIAMGSCATSGNIYDSYSVVQGVDRFVPVDIYVPGCPPTPEALFDGILKLQERIMQKRVFVKQPEQVRPRVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3F7</accession>
    <name>A0A1W1I3F7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47547">
        <property type="protein sequence ID" value="SLM47547"/>
        <property type="gene ID" value="NSJP_1376"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1376"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="341" mass="38365" checksum="C2A2CCFE88D87760" modified="2017-06-07" version="1">MVHRIPRQGWKRSRRRRARPGRSRRLRGKARGSSMMDVSRACDSVMAGNEIPGLLRRFGVVKELKVVFRDQSMVDEPWPVDESVPEVAPDQNDDEMAGLPGLEERQGFKEFVKRAESPRQGNQRPGPDEEMHLSHGKIAELETEFRRDVRIRALLVRQGDVQSDRFGADVRSAAIRRFHDARAAAGDDHIVATVADLTGRRDEASEFARDVVILGERKLPSRDFQPPLPGPVIREPCRLILSRPQQLSGGLRLLHPGAAEDDNGRLNTLFALDQFRFQQFQAYAYGTQVVSLKELQIAIGWNVGRIGRQAFHNAGDYSGTGIERQFGDEERGEGDVRTDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3R1</accession>
    <name>A0A1W1I3R1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47605">
        <property type="protein sequence ID" value="SLM47605"/>
        <property type="gene ID" value="NSJP_1433"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1433"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="69" mass="7900" checksum="59E8F04FF6ABE570" modified="2017-06-07" version="1">MLIVLQLNGTGVIARHETARSPIRHDTYVERVRELRIHICQAAGLHRQTRTILLNLSEVTEPLGYNSMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3W2</accession>
    <name>A0A1W1I3W2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetylornithine aminotransferase</fullName>
            <shortName evidence="2">ACOAT</shortName>
            <ecNumber evidence="2">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">argD</name>
        <name evidence="4" type="ORF">NSJP_1526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:18049"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.6.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="2">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1526"/>
    <dbReference type="EnsemblBacteria" id="SLM47698">
        <property type="protein sequence ID" value="SLM47698"/>
        <property type="gene ID" value="NSJP_1526"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1526"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="105"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="223"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="403" mass="44256" checksum="42E1C05608AAA0C8" modified="2017-06-07" version="1">MPTEELKNTSDQILMGTYTRQPISIVRGRGMKVYDLEGREYTDFVAGVAVNVLGHGHPDLVAAIQRQAAQLIHASNLYYTEPQVKLAQMLVDHSFAERVFFCNSGAEANEAAIKLARRYSHGKYGPGRHEIVTMKNSFHGRTMATLTATGQDKVQKGYEPLLPGFSYVEFNHFAKLEQAIGDKTAAVMIEPIQGEGGVHVADREYLKAVRELCTRRDMLLIFDEVQTGMGRTGTLFAYEQFGVEPDIMTLAKGLGGGLPIGACLAKDSVAQSMPPGSHGSTFGGNPLACAAALAVFRVLLEGRVLDHARQMGDYLAKGLLECKDRHHAVRAVRGLGLLQGMEVEIDAKSVVSECLRRGMLINATSERVLRFIPPLIVTERDIDRLIEVLSHVFNRHTMESPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Y8</accession>
    <name>A0A1W1I3Y8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1542"/>
    <dbReference type="EnsemblBacteria" id="SLM47714">
        <property type="protein sequence ID" value="SLM47714"/>
        <property type="gene ID" value="NSJP_1542"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1542"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023292">
        <property type="entry name" value="NTP_PyroPHydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="136" mass="15271" checksum="092D13665BEAB17C" modified="2017-06-07" version="1">MTNKDESMHDAQAMVEAFHRMFDIVTNSTPTAVGPDTRQLRIRLIQEEFDELREALESDDLPAVAKELADLLYVVYGTAVSYGIDMDPVFREVHRSNMSKVGGHKREDGKWVKPPTYSPALIGPILEGLRAEGKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I430</accession>
    <name>A0A1W1I430_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UPF0114 protein NSJP_1605</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_1605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the UPF0114 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47777">
        <property type="protein sequence ID" value="SLM47777"/>
        <property type="gene ID" value="NSJP_1605"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1605"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00143">
        <property type="entry name" value="UPF0114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005134">
        <property type="entry name" value="UPF0114"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020761">
        <property type="entry name" value="UPF0114_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38596">
        <property type="entry name" value="PTHR38596"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03350">
        <property type="entry name" value="UPF0114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00645">
        <property type="entry name" value="HI0507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="186" mass="20869" checksum="5DE248F0A3633D39" modified="2017-06-07" version="1">MSSGTPPASDNALESSQEVIHPIEHAFETVVFASRWIQAPLYGGLIIAELLYAYKFLVELWEMAIHIRQLQETEFMLGVLGLIDVTMVANLLTMVIIGGYATFVSKLNLETHPDRPDWLTHVDPGTIKIKLAASLIGISSIHLLKAFVDVANENPEHIKWKIFIHVTFLSSAILLAWTDRLMLKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I448</accession>
    <name>A0A1W1I448_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein DevR (DosR)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">devR</name>
        <name evidence="5" type="ORF">NSJP_1608</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47780">
        <property type="protein sequence ID" value="SLM47780"/>
        <property type="gene ID" value="NSJP_1608"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1608"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="225" mass="24796" checksum="9DBBBD585C35A9B1" modified="2017-06-07" version="1">MTKDLPLKIVIVDDHEVVRHGLRSLLSLEEDFKIVGEAGTVAEALAVVERVKPQVVLLDVKLPDATGMEACRKLLAVAPNLRVLILTSYAEDASIIGAVQSGAHGYVLKDIRTDELIQAIRAVASGKGHLDPRVAQQALHWIRTQYRTESPGRQGPKLSPQERLIVPLLAQGKTNKEIAAHLSLSDKTVKNYLANIFEKLNVRRRTEAVAWFIREGRSSYSGPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I470</accession>
    <name>A0A1W1I470_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1645"/>
    <dbReference type="EnsemblBacteria" id="SLM47817">
        <property type="protein sequence ID" value="SLM47817"/>
        <property type="gene ID" value="NSJP_1645"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1645"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="6"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="88" mass="9939" checksum="9C939022CCB1C262" modified="2017-06-07" version="1">MEKTLFRVGEAADFLSVSRWTIYRWLEQGKLRGTKIGKGSIRVFRDSLDGLIQQNRTDDWTRSSVPAAKWPSTVAATAMHPLGDTDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I484</accession>
    <name>A0A1W1I484_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenosine 5'-phosphosulfate reductase</fullName>
            <shortName evidence="3">APS reductase</shortName>
            <ecNumber evidence="3">1.8.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-adenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Thioredoxin-dependent 5'-adenylylsulfate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">cysH</name>
        <name evidence="6" type="ORF">NSJP_1461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate</text>
            <dbReference type="Rhea" id="RHEA:21976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.8.4.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="3">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.10" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1461"/>
    <dbReference type="EnsemblBacteria" id="SLM47633">
        <property type="protein sequence ID" value="SLM47633"/>
        <property type="gene ID" value="NSJP_1461"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1461"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043866">
        <property type="term" value="F:adenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="5">
        <location>
            <begin position="39"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; cysteine thiosulfonate intermediate" evidence="3">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="239" mass="27357" checksum="CC3E1D9B6B0B2144" modified="2017-06-07" version="1">MTQVSPNDMEALQVWSDSFASKQPQEVLAAAIERYAPKIVLACSFGAEDVVLVDMVHRINPSVPLFYLDTDFLFPETHATRDRIAERYNLKPAQMLQVKSLLTPADQTARHGEALWAKDPDQCCKIRKVEPLNRILKTYDAWITGIRREQSPTRANAKMIEWDNIFGLVKVNPLAAWTWADVWTYIKIYEVPYNELHDRNYPSIGCTHCTKPVMPGEDPRSGRWQGREKTECGLHKKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4B5</accession>
    <name>A0A1W1I4B5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47663">
        <property type="protein sequence ID" value="SLM47663"/>
        <property type="gene ID" value="NSJP_1491"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1491"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="47" mass="5101" checksum="EFDA9BAA1C22D5D8" modified="2017-06-07" version="1">MRGHMGRLILTKARGNLQGKAWIPEWLGLEGGVLLGRNLVGWTADTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4F2</accession>
    <name>A0A1W1I4F2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative nickel insertion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the LarC family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1577"/>
    <dbReference type="EnsemblBacteria" id="SLM47749">
        <property type="protein sequence ID" value="SLM47749"/>
        <property type="gene ID" value="NSJP_1577"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1577"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01074">
        <property type="entry name" value="LarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002822">
        <property type="entry name" value="Ni_insertion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36566">
        <property type="entry name" value="PTHR36566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01969">
        <property type="entry name" value="DUF111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00299">
        <property type="entry name" value="TIGR00299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 2" id="KW-0533">Nickel</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="400" mass="43392" checksum="926C0AE9959987D2" modified="2017-06-07" version="1">MGAHLHFDCFSGISGDMTLGALVDVGLPFGDLVRGLKRLGISGFQLRRRRVRRAALHATKIDVVLRAGLRAPLSLKQIHTVLSKSRLSEQVKLQSRTVFDRLAEAESRAHRVPKAHVHFHEVSVLDSFVDIVGSLIGCEILNVSRVTASPVNVGSGTLQSAHGILPAPGPAVAVLAEGIPIYSAGPPRELATPTGVALLRSLTTEFGPMPLLSPDAVGYGAGDANPEGWPNVLRVFLASPKTRQPREQDRVVHIETNLDDVNPQTYEHVVERLFRRHALDVTLTPVIMKRGRPGIVLTVLAAPDHAQAVLDVLFEETTALGVRVQEIARQVLPRRFVTVQLPGGSVRVKVAGLDGGRTKAAPEYLDCKRIAERTGRPVKSILEEAATAYRRSRANKKDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4J1</accession>
    <name>A0A1W1I4J1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Sensor protein PilS</fullName>
            <ecNumber evidence="6">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1750"/>
    <dbReference type="EnsemblBacteria" id="SLM47922">
        <property type="protein sequence ID" value="SLM47922"/>
        <property type="gene ID" value="NSJP_1750"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1750"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="197"/>
            <end position="240"/>
        </location>
    </feature>
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        <location>
            <begin position="266"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="330"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="563" mass="61738" checksum="B53FC491628F2D68" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4U8</accession>
    <name>A0A1W1I4U8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48005">
        <property type="protein sequence ID" value="SLM48005"/>
        <property type="gene ID" value="NSJP_1833"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1833"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
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        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="333" mass="36586" checksum="16A797F0F2CA2193" modified="2017-06-07" version="1">MGKAAREKRERRRALSLSQMAPNLPEGSGMGSTIQNWLALPTLGLAIALVVTVIGARLTTDSANILLAVAWILATISIFTIPPITQSDLIPRILYTLLLSSAVGLGLYQLRWVEPTPPTTLIKPSETTPTITLTVRFDPLVFFPFSIPAQTTSYAILARPKEDIPWGAYEIKNDGNSPIIWPEKQSLKWGGPKLPQKKSEDFPGMPDMAIALDITNHSNNELIDVKAEVEFAFAEAIQEEKSVRSGPVTVTRRHTAIIPILKQNRTVRLYIGNQSSKHFVVASFPTEATALVPSETERRKIKLVKIGTNVVEALPMFSLSPAKVRWSGFPTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4X9</accession>
    <name>A0A1W1I4X9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48064">
        <property type="protein sequence ID" value="SLM48064"/>
        <property type="gene ID" value="NSJP_1891"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1891"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="54" mass="6164" checksum="D48D60FBE279C9CC" modified="2017-06-07" version="1">MEEASKILFEFAETLYLIKESHNLAKLLVELVAEKSTPLIECFSYSSQQCPIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I571</accession>
    <name>A0A1W1I571_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
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            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1996"/>
    <dbReference type="EnsemblBacteria" id="SLM48168">
        <property type="protein sequence ID" value="SLM48168"/>
        <property type="gene ID" value="NSJP_1996"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1996"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="391" mass="44540" checksum="ACB617F0F7675B15" modified="2017-06-07" version="1">MAEASYTMMDGDTLTGAEEKVLQRAQRKAVEEAGVYLEATFLDFEREFQGQRIQNSTLEIRTIAAGIAETEILESRRSFENDRPVFFVRIRATVNIESLVAAIRRQQSEEKLSQHFRQLQQENQHLRKQLKEFQQDPIGVRMLVIEPNGKSESAHQARSLVSRAMQSQNLREKIQLSSEAIALDSRFVEPFLIRGQTFLRLVSLAFAQHSSPDAYADYLQKAQADFDRALQLDSQNAWSWVGKGDVQTWFKQMDEAAVSYEQALALDPFFDIARQRLIVVYTTQARRQAESKHPHQALATLKRLLDAQTPDSWIPYQKEAYLLRSDILLKLNRPGQALEDLSTVIRVDPTNTGALLTRAKLYQNQLQGTLAKDDLERACVLGSVEACEQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I581</accession>
    <name>A0A1W1I581_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Proteasome, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1984"/>
    <dbReference type="EnsemblBacteria" id="SLM48156">
        <property type="protein sequence ID" value="SLM48156"/>
        <property type="gene ID" value="NSJP_1984"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1984"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="265" mass="29587" checksum="36038645A75AEE99" modified="2017-06-07" version="1">MYDEPYRWVEAVGNRRQYLDEQFKQGSPVIAVTYDAGILLLTVSKGTPKLYEIYDRLALGGMGHPADLEKLRFSLLEMAHVEGFNRSPSDVTGGRMVKYGIAPVIKQAFEEVYKAPFIVKILLAELGQKPDKDRFLTINYDGTFEERTHCAVLAANRSVEQSMTAYLQARPSASGTLDQAVGHALHAWVLGEQAQRRAAEMRSEPEASAPESAQTEIDAKTVAEYVRDHLDGRTIECAVLDRNQRGSAKYRAPLKPAELGEWQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5E0</accession>
    <name>A0A1W1I5E0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48216">
        <property type="protein sequence ID" value="SLM48216"/>
        <property type="gene ID" value="NSJP_2044"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2044"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="63" mass="7239" checksum="3E3C3CA2BB1B0891" modified="2017-06-07" version="1">MLFWRRGVPRTLWTEGEESLVGKSLAVGQVTAVITGETQRIYPSALRSFELLSKRTFERVRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5G3</accession>
    <name>A0A1W1I5G3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2064"/>
    <dbReference type="EnsemblBacteria" id="SLM48236">
        <property type="protein sequence ID" value="SLM48236"/>
        <property type="gene ID" value="NSJP_2064"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2064"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="130" mass="15210" checksum="D0C1C112101476E6" modified="2017-06-07" version="1">MIQQRIEEVTKANERFYEAFGSLDIAKMDEVWAHLEYVTCIHPGWTLRTEWRAVRDSWVLIFNNTFSMQFDLTDVTVQVAGDIAWVICVENITSQQSDEPRHMRVLATNLFERIGDEWLMTHHHGSAVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5M8</accession>
    <name>A0A1W1I5M8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48322">
        <property type="protein sequence ID" value="SLM48322"/>
        <property type="gene ID" value="NSJP_2150"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2150"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="291" mass="32489" checksum="999F1E213D3F666C" modified="2017-06-07" version="1">MGALYSWLSGLHEEAANRLLQGTFKEGLVRMTRGTVVVLGAGYTGRRLIARLTQTSRPFFATSRDPDRHLAMLPPSQRLNFDLHRPETWATIPAQADIVWCFPAAPVDLVRACAEVLKTGTGRMVVLGSTSAYDTDDTRLYPPPWLDETAPIDLSQPRVQGEEYLRNELGAVILRVAGIYGEDRNPLNWIRSGRVGPSRRFVNLIHVEDLADICLLALEKGTRGEIYNVSDGTPRTWEQICLVARERWGVSSPAETTAREPGKRIDARKLRETLHAPLRHPDLYEALGVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Q8</accession>
    <name>A0A1W1I5Q8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplU</name>
        <name evidence="6" type="ORF">NSJP_2109</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2109"/>
    <dbReference type="EnsemblBacteria" id="SLM48281">
        <property type="protein sequence ID" value="SLM48281"/>
        <property type="gene ID" value="NSJP_2109"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2109"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="104" mass="11489" checksum="134C3027BA44692C" modified="2017-06-07" version="1">MYAIVETGGKQYRVEHGSLVQVESLPGDVGGTVELDHVRLVHGDKGVVIGQPLVAGAKVTAEIVNQGRTRSMIVFKKQRRKNYRRTKGHRQGFTKLRITGIHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5R6</accession>
    <name>A0A1W1I5R6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48368">
        <property type="protein sequence ID" value="SLM48368"/>
        <property type="gene ID" value="NSJP_2196"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2196"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="205" mass="22014" checksum="5BBAA7766EB2ED8F" modified="2017-06-07" version="1">MSDQPDPYEEGKRAGVHPLIVVFAVLLGLWLFVALIVPSSKNKQATGTEGPAMPMIEDPEAAPVIFKVEATVPDMNAVSLVVPAQATESQVVGLLKRLKKERLAGSLSDLIPATTPGHKLGDHAIADIYVTSDPKYAKSEVIRTLTRGAHAPGGLYPDAVPFEVAMEEIKGHYRIDLHNTGAPDTGSVGFADESGVHSRHYRKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I635</accession>
    <name>A0A1W1I635_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Histidine kinase</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2300"/>
    <dbReference type="EnsemblBacteria" id="SLM48472">
        <property type="protein sequence ID" value="SLM48472"/>
        <property type="gene ID" value="NSJP_2300"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2300"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="150"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="384" mass="40973" checksum="AFF33CBE4F6596AF" modified="2017-06-07" version="1">MNKQNRILLAVAGVVFLAIVILETAAPANIVAAYGLVFPILLVARLRNRVLMVLAVVCCVAATYLGLMQPTKPGRFQAAVINRSVVAGVLMVVAYVGMTWEERKAREEASKAALAQQTESLLRANTLLVDAKDQLNRSERLAAVGQLVASVAHEVGTPLHSIAWHVQALAEEPGVTPAMKKRITVIDEQLNRVVRIIQDLLSSTRQRKPEPVWMSTERVINPATALMEPAFHAKGVSLSTELAIGIPHVWADAEKVHQVLVNLLANALAATAQHGSVIVQASGRPATAEEVDVARRMAPDMTAMMVTIAVRDTGVGMPAADVQRAFHPFFTTKEVGKGTGLGLFLSRETVTAHGGSLSLQSEAGRGTVVTVILPGKMPNPSATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I640</accession>
    <name>A0A1W1I640_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48339">
        <property type="protein sequence ID" value="SLM48339"/>
        <property type="gene ID" value="NSJP_2167"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2167"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="48"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="220" mass="24780" checksum="2099781BA49F3D54" modified="2017-06-07" version="1">MMDRILEPELMEDDEQVVAYANADFAEENQGFVDRFKEYFPDFTAGHILDLGCGPGDIPIRLAKAFPGCRVTGIDASAPMIRFAERAVQSEGLQDRIAFQCERFERLAGANIVEAAVSNSLLHHLPNPLQFWNKLRQLVKPGSPVLVMDLLRPDSPEEARVIVDRYASGEPDVLRRDFYNSLLAAFTEDEITSQLARMNLTRLLIDVVDDRHWVVGGIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I674</accession>
    <name>A0A1W1I674_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48441">
        <property type="protein sequence ID" value="SLM48441"/>
        <property type="gene ID" value="NSJP_2269"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2269"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="1">
        <location>
            <begin position="99"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="137" mass="15592" checksum="B14A832B381BFD8C" modified="2017-06-07" version="1">MAVEEKWKANLEKVAFMKRFPGLLVEWAALERKSVEAVIPLTGKQGAAAIVFNDGTFTVAPPMSAQPYELGETLQRARPYLERSHPDAYAEYDRLVKKDQDALKAARLEKIVGAIRNNLEQIPELKDQLKRLVEEWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I684</accession>
    <name>A0A1W1I684_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rplC</name>
        <name evidence="8" type="ORF">NSJP_2338</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2338"/>
    <dbReference type="EnsemblBacteria" id="SLM48510">
        <property type="protein sequence ID" value="SLM48510"/>
        <property type="gene ID" value="NSJP_2338"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2338"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="206" mass="22290" checksum="385C94CBD9085A19" modified="2017-06-07" version="1">MTNGLLGKKLGMTQVFDESQLVPVTVISAGPCRVVTVKTKERDGYEAVQLSYGDTKERLLSKAELGHLKKHEASASRTLKEFKKTGDVAIGQTIKVDIFKKGDWVDVIGVSKGKGFQGVVRRHHYSGGPESHGSMFHRAPGSIGASSFPSRVWKGKTLPGHMGAERVTSQRLKVIESRPDENLLFVRGAVPGAANGLLVVRKSKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I695</accession>
    <name>A0A1W1I695_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">rpsE</name>
        <name evidence="11" type="ORF">NSJP_2355</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2355"/>
    <dbReference type="EnsemblBacteria" id="SLM48527">
        <property type="protein sequence ID" value="SLM48527"/>
        <property type="gene ID" value="NSJP_2355"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2355"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="10"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="169" mass="17705" checksum="F0A62710BFC2FFAB" modified="2017-06-07" version="1">MRVNPDELSLKDKVVFINRVAKVVKGGKRFNFCALVVVGDGQGWVGIGKGKAAEVPVAISKAVQQAKKNLVHVPLKSGTIPHEVHGLFGGEHVLLKPAAEGTGIIAGGAVRAVVELVGAHNVISKTLGRGNPFNTVRATLDGLTQLRNPEEVMQLRRGLTDVRAAGVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6M4</accession>
    <name>A0A1W1I6M4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2490"/>
    <dbReference type="EnsemblBacteria" id="SLM48662">
        <property type="protein sequence ID" value="SLM48662"/>
        <property type="gene ID" value="NSJP_2490"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2490"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013162030" evidence="2">
        <location>
            <begin position="27"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="251"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="336" mass="35857" checksum="D745DF71A227B548" modified="2017-06-07" version="1">MRLWRLQAAVCLVLAWMTLLPAPSSAGSSDQAAILEQAKRATVGVLEDTQDPRTPEKPGRISVRGTGFHLRDGYIVTARHAVEKNSPSGPTVAKIIHVLTSDLHELVAQLVGDSAYLDVVVYRLNEKDRPTVTTSASFAASEAGSGTEVFTIGYPLGWGPTMAFGRIGNANTFLQTVDTRLLQADLSVCSGNSGGALFNGAGEVVGVMHAIIQTEKDELQGHCSRLAFAIPTTLAERMVNAALSGKPLAFSKLGIHMTTVKDGTKWRIAVKDVGEPAKSAGIQKHDLLLAIEDTDILDAAQLKNYLIERTTPGQRVAVKVRRIDADLTFHVVLGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Q5</accession>
    <name>A0A1W1I6Q5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase_M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NSJP_2502</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48674">
        <property type="protein sequence ID" value="SLM48674"/>
        <property type="gene ID" value="NSJP_2502"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2502"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012529057" description="Peptidase_M48 domain-containing protein" evidence="8">
        <location>
            <begin position="31"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="9">
        <location>
            <begin position="44"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM48674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="582" mass="63895" checksum="8453136123C8208B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6T1</accession>
    <name>A0A1W1I6T1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48722">
        <property type="protein sequence ID" value="SLM48722"/>
        <property type="gene ID" value="NSJP_2555"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2555"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013071466" evidence="1">
        <location>
            <begin position="21"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="162" mass="17484" checksum="CCC54D7FE02F2826" modified="2017-06-07" version="1">MKPLLLMTAAGLIAIFTAMQGEPSHAAAAEKKPSEPNACSLLSIEELGRLLGSPIRRPRPDTAEKGTACRFSVGGTDTLNISLWPTTPKSFDEFKKTLSDGGARLENVAGVGDAGYYWDTRIYVRTGDNGVTVWFGVSVDGVNQKRRQQVFSVAQAAVNRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6T5</accession>
    <name>A0A1W1I6T5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48726">
        <property type="protein sequence ID" value="SLM48726"/>
        <property type="gene ID" value="NSJP_2559"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2559"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="266" mass="30354" checksum="E5F7A070C29931D9" modified="2017-06-07" version="1">MCHEASTRRRSFALLRWILSLVLLAWLHEPALGAVQLHVIETDPPSPSSLGHWEEFHVHLGYETDQAIHIYVEAFHGHSRVSSFTSASPLYPAGRGEADVWVAHDKPAQVDRIVARADARNTRQAQIDIPVQLTWTGIRQTPPRQPAAWIERLRAENASRLNAELEAHRNRPEPWWENVLFFLMMWAGPVYVIMQIRLLRRYRDGWRYAALVPVIPMVGVLIYTVYAFQAGSNIFPLVLILTSPFALVYLLGLMTVHRVALRTSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6U1</accession>
    <name>A0A1W1I6U1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gpx</name>
        <name evidence="6" type="ORF">NSJP_2565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2565"/>
    <dbReference type="EnsemblBacteria" id="SLM48732">
        <property type="protein sequence ID" value="SLM48732"/>
        <property type="gene ID" value="NSJP_2565"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2565"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="158" mass="17462" checksum="E1A0FBF9BD132CE5" modified="2017-06-07" version="1">MNLYDIDLVTIDGKPQKMAAYRGRTLLIVNVASECGFTPQYAGLQVLYEKFKDRGFVVLGFPCNQFGHQEPGGEAEIGQFCSRNYGVTFPMFAKIDVNGANAHPLYQYLKSEKPGILGTEAIKWNFTKFLVGSDGTILKRYAPSDKPEAIEADVAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Y9</accession>
    <name>A0A1W1I6Y9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RND efflux system, outer membrane factor lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ttgC</name>
        <name evidence="5" type="ORF">NSJP_2519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2519"/>
    <dbReference type="EnsemblBacteria" id="SLM48691">
        <property type="protein sequence ID" value="SLM48691"/>
        <property type="gene ID" value="NSJP_2519"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2519"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="392"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="497" mass="54183" checksum="2CA64B4C2BB71161" modified="2017-06-07" version="1">MYRWSLLLLLVTVLAGCKMGPDYMRPDVPSGESWRIAPAATESIANLSWWELLQDKELQNVMQIALTENQDVRTAVASVDQYRAQLVMTKWDLAPSLSYGASAFMYHTTGGDATTIPGGGGAIVLPGQAGKDSTTFSNTIGFGNLKWELDLWGRLRRAVEASEAQMFSQEENQRTVILSLVGSVGEAYFGLRSLDLQVDITKRTLKSWEESVRLSQLRYKQGYIPKLDLDRFEAERAGTAAKLADLERQVVQKENQLNALMGRKPAAITRGLPLTEQPMPPSVPAGLPSELLQRRPDLQQAEQTLAAATANIGVAQAARFPQLALTGAVGGANANLSGTSIGPLFIQNVAASLAGPLLNASALGYQVSVNEMKARQAALQYEKAVVNAFKEVEDALIAVQKTREQREAQEQQVAALQSALKFADQRYQGGRASYLDVLTSQRSLFEAELALARTLQTQLVSVVQLYTALGGGWSVTEHPEQNLPDPRVQKNISARVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I736</accession>
    <name>A0A1W1I736_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Cupin 2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2564"/>
    <dbReference type="EnsemblBacteria" id="SLM48731">
        <property type="protein sequence ID" value="SLM48731"/>
        <property type="gene ID" value="NSJP_2564"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2564"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="118" mass="12694" checksum="31E6B090B8E1A762" modified="2017-06-07" version="1">MVMDVTTLKNIAGQSELNKRGKVLARIGEANVCVSRFSQHPKWEIHPKGEEVLIGISGELSVVILDPSGPRTIVVKSGDVAVVPENTWHSPVPHGEVSVLSMGDYAGTIVSNNDDPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I761</accession>
    <name>A0A1W1I761_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Carboxymethylenebutenolidase</fullName>
            <ecNumber evidence="2">3.1.1.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.45" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2673"/>
    <dbReference type="EnsemblBacteria" id="SLM48840">
        <property type="protein sequence ID" value="SLM48840"/>
        <property type="gene ID" value="NSJP_2673"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2673"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008806">
        <property type="term" value="F:carboxymethylenebutenolidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="52"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="266" mass="29145" checksum="B8F126FD5DB72036" modified="2017-06-07" version="1">MTTSASAPFTLQQIGTGTARFPSGVAIPTSTDASVDPYIRTRTTKDVQVECILFWPQEKGTYPGIVLLHEWWGLNSQIKDLGAQLACEGYGVIIPNLYGRLGGTVTASAEVADALMGKLNDSLILQDVNSCCEYLNTRDYIKRNIHGVVGFGMGGTFAIRFAGQRKRLRAAVSYYGRIPATDSALKDLYCPLLYHRGDKDTWVSQQDVDRLTASAQEHGKRVQVRTYPGAGHAFSNETRPDGYRPDATAEAWSTTTSFLKTCFQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7A5</accession>
    <name>A0A1W1I7A5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2582"/>
    <dbReference type="EnsemblBacteria" id="SLM48749">
        <property type="protein sequence ID" value="SLM48749"/>
        <property type="gene ID" value="NSJP_2582"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2582"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009833">
        <property type="entry name" value="DUF1398"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036696">
        <property type="entry name" value="YdfO-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07166">
        <property type="entry name" value="DUF1398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160419">
        <property type="entry name" value="SSF160419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="138" mass="15153" checksum="CB5B56854554EF7A" modified="2017-06-07" version="1">MSKAIENLQAAQQRAMAVRPKVGGFPHLAEVLRQAGVTRNVWSLPACQSLYLTKDGPVVAQGAPLLSGMGDVPRFDQPALIKALRTDQAGESTFQEFLAAAWHAGVVRYEVDFAERTVIYSGCQGEEYVERYPMVEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7F9</accession>
    <name>A0A1W1I7F9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48947">
        <property type="protein sequence ID" value="SLM48947"/>
        <property type="gene ID" value="NSJP_2780"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2780"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="123" mass="13455" checksum="225352334374E5D7" modified="2017-06-07" version="1">MEQKILIIDDHLETWQILSAIVRSQGFRPVWAADGVNAMSEARKQRPQVVLLDLGLPGGDGFVVLERLKANKLLSDIPVIVVTALEAKTTESKALEHGAAAFLQKPVKPDELVATIHAVVKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7G6</accession>
    <name>A0A1W1I7G6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-(Acyl-carrier-protein) reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fabG</name>
        <name evidence="2" type="ORF">NSJP_2789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2789"/>
    <dbReference type="EnsemblBacteria" id="SLM48956">
        <property type="protein sequence ID" value="SLM48956"/>
        <property type="gene ID" value="NSJP_2789"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2789"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="239" mass="25078" checksum="EF4934FED84EE29D" modified="2017-06-07" version="1">MSRLDGKVAIVTGSSSGIGKAIALRFGREGARVVVAARRLAHCEETVASIVRSGGEACAIQTDVSEESQVEALLAETVKRWGRVDLLVNNAGIGGGGRLADTTTKAFDEIINVNLRGTFFCCRAGFNRMRQQGGGVIINVSSVAGLQAWSGTGVYSASKHGVMALTKALADEGRPYGIKVSAICPGGVADELVDASPEEILRSEKIDPFDVAETALYLASLGPYATVHQIVIDRLGADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Q7</accession>
    <name>A0A1W1I7Q7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48843">
        <property type="protein sequence ID" value="SLM48843"/>
        <property type="gene ID" value="NSJP_2676"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2676"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="207" mass="22478" checksum="EB123B447876B86D" modified="2017-06-07" version="1">MICRILGLSSTPSRSYGLLYNPPMLIRSLLLLLAVATSTMVLSAVSAGAEGRAPSQHVGSAMALLATLEDARILPPEGTPEANHVIRVVIQFQSVFAKSTNPAVHEFFHQALVTHVGEAQAAPEQAAFAKTGWTGTVLAALAERRRSADPGDLEKLAAGFSAFNLTLQDFEFLTGLFDQARREYRNRGREIEEVFAERRRDMPGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I815</accession>
    <name>A0A1W1I815_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2990"/>
    <dbReference type="EnsemblBacteria" id="SLM49157">
        <property type="protein sequence ID" value="SLM49157"/>
        <property type="gene ID" value="NSJP_2990"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2990"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="362" mass="39712" checksum="DE830A623752322E" modified="2017-06-07" version="1">MPVIWAAISGHGYGHAAQVVPVLNALGTLIPDLTVILRTLVPASFFADRLRLPWTLQPVQQDIGCIQQGPMQIDVAATWEAHARFHAEWSQRLEQEVAAIRSAGPRVIVADTPYLAVRAGVEAGVPTVCLANLTWHDILTPFVDGTRPDQHDILSEIGGHYAVANSALRIAPGLPLSPIRHVTNIGAIAELAVPVRDQLRKRLELLDDERLVLVGFGGVPLTSLPWEAMENMGGYHFIVDGPITRRSSRITSLGSLPYHFRSMIPSADVIMTKPGYGTVVEAVAARVPVVYVRRYIFADEQPLVTFLEQYSRSSELSKEDFQIGKWPPAFEAVERQRITQAVPSFTGAADAAGHLARYFESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I889</accession>
    <name>A0A1W1I889_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="8">ALP N-acyltransferase</shortName>
            <ecNumber evidence="8">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lnt</name>
        <name evidence="10" type="ORF">NSJP_3038</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49205">
        <property type="protein sequence ID" value="SLM49205"/>
        <property type="gene ID" value="NSJP_3038"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3038"/>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="235"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM49205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="540" mass="58024" checksum="D10D0CF0FFE253CB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8D0</accession>
    <name>A0A1W1I8D0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPM_phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3110"/>
    <dbReference type="EnsemblBacteria" id="SLM49277">
        <property type="protein sequence ID" value="SLM49277"/>
        <property type="gene ID" value="NSJP_3110"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3110"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="5">
        <location>
            <begin position="41"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="244" mass="26856" checksum="0F3EB57AC865DBE1" modified="2017-06-07" version="1">MMLKILLVFSGLLLLGAIDGSVSARPYDRPTVKLPDPMGYVSDHAQTLDADWRARIRSVCQDLERKTGVEMVVVTVPTIKPFGSANEFAGALYEKWGIGSTQQEHGVLILLAVEERQAAMTLGRQMFPVITPAVMNQVGGEYLHPAVERGHFGEGLYRTVVALASVSQEIRTGTLSKTHYRNFGIWITVLTSVGALLFLWWISRPDLRHPYRRIRKAEYWGTGQGGFGGNWGGFGGGTNGEGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8D5</accession>
    <name>A0A1W1I8D5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49308">
        <property type="protein sequence ID" value="SLM49308"/>
        <property type="gene ID" value="NSJP_3141"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3141"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013229783" evidence="2">
        <location>
            <begin position="20"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="428" mass="45717" checksum="BFD6ED8E98E0F908" modified="2017-06-07" version="1">MVLFVIFVTLFLTACSSSGDTSPQSTTVVEPQTPTQPGVPPPGNPNPNQPTTPPPTPPSIPPASGRTPLPPWLSYCDDAGCRNQSPAVISTCGGTCRATTIIPSVDGIRISGLAFPIIGASPVLVSGFADVFATVYPQGPGAFVTVPYAPSVVLSTESDVTMTWYELPPVWGGVTPVDFVTDQRTDPATGLRTVFYRQASFQAGNAGTEIFTNALAIQSAERRLTGVTSDPITALVMPTELATSEHGEGNFSYGNGVITANYAHPLYFNLFGGLVPTVTPRIAHEIAHELFNEISGSFGGNYSCFNEGQADALAYSSGFLPLDQFGPRGLRGIEYTKGCDQMSESHDVGNCYFWPLFQGGHLTPQFWEKLYHPKRSYNFDSCSPTNRRTGNSLFVMFTDATGGADLRSAFDAYHIPHAATYADALAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8J9</accession>
    <name>A0A1W1I8J9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49189">
        <property type="protein sequence ID" value="SLM49189"/>
        <property type="gene ID" value="NSJP_3022"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3022"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012212953" evidence="2">
        <location>
            <begin position="30"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="145" mass="15526" checksum="56C92924EC8758C3" modified="2017-06-07" version="1">MMSRCWIRCGGVAMLLMYMCLSHTIPAKAEPIKNPDKCKGGVPDGAFHCLNKPGQWVECNGSGDYMCCAPNAQGGKDCEQIESFQTPKNPKANMGAVHGGQLQVAPTNPPPRTTPVPKAGMNAPIMRRGVEGEESTAPPQEETNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8L1</accession>
    <name>A0A1W1I8L1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49199">
        <property type="protein sequence ID" value="SLM49199"/>
        <property type="gene ID" value="NSJP_3032"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3032"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="401" mass="43585" checksum="76E2BBB0F1D63CD7" modified="2017-06-07" version="1">MRFRSSSRRRFVAIGMAVFLAGMVGSPIRSFPLGKELQLTPDEPPIPTTCTPPRFTGQSQFFSSPKGTAKYSFDGICTSPQKPGAQLQYRLEASWSPSETDPQKPNASESIAMTGYEPFIPVRAPGGRIFMFWTGRCKQDPWLQPEAASCRIVGVSIPEDLRVVVPELQTLNFPKTENMIAPADRQRLHAQYLRVNSPVAGTKRIPGVLGPTDDMFTITNPVRNALVQQGQLFLKADAPKTGATQMTELEFRWLDAPANQSNVPNVFAVETSKLLQGYQVDQAVTRGNAGRWEIRARASGKAVPGPWSFPVQFKLFLTQPTQSKKQASPIPQTVPLPSSAVQAAPQGSAAPMVRPPAVTAPPSQGSSSSSGMIRMRGVEGPDETEDGQPADHSFRPEGKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Q0</accession>
    <name>A0A1W1I8Q0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">DNA ligase</fullName>
            <ecNumber evidence="9 10">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">ligA</name>
        <name evidence="12" type="ORF">NSJP_3198</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="9 10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3198"/>
    <dbReference type="EnsemblBacteria" id="SLM49365">
        <property type="protein sequence ID" value="SLM49365"/>
        <property type="gene ID" value="NSJP_3198"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3198"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="592"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="34"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM49365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="672" mass="73975" checksum="9D40FE24AF83D96D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8T3</accession>
    <name>A0A1W1I8T3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49427">
        <property type="protein sequence ID" value="SLM49427"/>
        <property type="gene ID" value="NSJP_3261"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3261"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007367">
        <property type="entry name" value="DUF433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04255">
        <property type="entry name" value="DUF433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="71" mass="7905" checksum="8133A684A5F177A4" modified="2017-06-07" version="1">MIRHSLITSSPDILGGTPVFRDTRVPVQTLIEYLEGGQTIDDFLEGFPTVTREQVIAFLEEAKTRMLPVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8U1</accession>
    <name>A0A1W1I8U1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49289">
        <property type="protein sequence ID" value="SLM49289"/>
        <property type="gene ID" value="NSJP_3122"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3122"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="106" mass="11613" checksum="F3F9828B79BC4210" modified="2017-06-07" version="1">MDSEEQTLQEAIAAIAQSDPLVKLLQQVKVGRMKPTDPGLAAVTESWLATYRKAVMVEGLTKQALRRINPEPRLALLIETGIITSSHPFVSALVSNFEQALDRAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8V7</accession>
    <name>A0A1W1I8V7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49436">
        <property type="protein sequence ID" value="SLM49436"/>
        <property type="gene ID" value="NSJP_3269"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3269"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="71" mass="8401" checksum="D8B2501DB2A2508C" modified="2017-06-07" version="1">MLTKRLSRTTHTKKRYVTNRAGKKTGVVLSLRRYSQLMEDLHDLAMVAERRQEGLVGADEIRKRLRRRVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I944</accession>
    <name>A0A1W1I944_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49520">
        <property type="protein sequence ID" value="SLM49520"/>
        <property type="gene ID" value="NSJP_3353"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3353"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013139596" evidence="2">
        <location>
            <begin position="23"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="118" mass="12690" checksum="DB858FB0CEDE29E7" modified="2017-06-07" version="1">MRNKTKPVIVPMMFFTAMTICAWSGPSYSADQLPPGGSESPPGNNPETRPKTPPPDLPPPSRDPGIVKQPETVPHPDSVVVPPVVDPGMAVNPEQPQGTKPNRPPARDNPQHDPAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I954</accession>
    <name>A0A1W1I954_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3359"/>
    <dbReference type="EnsemblBacteria" id="SLM49526">
        <property type="protein sequence ID" value="SLM49526"/>
        <property type="gene ID" value="NSJP_3359"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3359"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012574134" evidence="2">
        <location>
            <begin position="20"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="138" mass="15047" checksum="6544DE66296407B5" modified="2017-06-07" version="1">MSLMPWLMTLILLAGCASAMPQIPATVLSAPAGTNAEINAQLERGNALFASRDWAGAEKVYREVVSFEPSMAEAHYNLAVALDHQGKQADARKHYVEAANLAPGNKVIWDSPVFHERTGGYGHNIERPSFQDPSHKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9M7</accession>
    <name>A0A1W1I9M7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_3580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3580"/>
    <dbReference type="EnsemblBacteria" id="SLM49747">
        <property type="protein sequence ID" value="SLM49747"/>
        <property type="gene ID" value="NSJP_3580"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3580"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="267" mass="28595" checksum="0F4E079533B34594" modified="2017-06-07" version="1">MRAEGSQPKSSRISPAPATPKPGTLYVLGTPIGDPDDITIRALRVLKTVPIIAAEDPRATQALLAHHGVTDGIAGTVTSYGPGNLEEKIPLLLRRLECGEDVALVSDCGMPVIHDPGCNLIAAAQQAGMPVTCLPGPSALTAAAALSGFSADRLVFDGRPPRARRQLIPFLRQRCRDRSASIFFVEERDLAPMLEVLAAIWPVRMIVLAQNLTMEDESIRRGTARSLLELGIPILRGIHRKLNTTLVVEGTTTTLRPAGRRKAGRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9R2</accession>
    <name>A0A1W1I9R2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rpsI</name>
        <name evidence="9" type="ORF">NSJP_3587</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3587"/>
    <dbReference type="EnsemblBacteria" id="SLM49754">
        <property type="protein sequence ID" value="SLM49754"/>
        <property type="gene ID" value="NSJP_3587"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3587"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="130" mass="14223" checksum="E0C08B064126631B" modified="2017-06-07" version="1">MAAAMQYATGRRKCAIARAWVTGTAGDITVNDQPLEKAFPRLTLRQIIQLPLELAGVSGKFSIKATVHGGGPTGQAGALRHAIARALVELSQPLRAPLKKEGLLTRDSRVKERKKYGQKGARKRFQYSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9S0</accession>
    <name>A0A1W1I9S0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3504"/>
    <dbReference type="EnsemblBacteria" id="SLM49671">
        <property type="protein sequence ID" value="SLM49671"/>
        <property type="gene ID" value="NSJP_3504"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3504"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="303"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="610" mass="68535" checksum="ED718913EDC375F9" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9U7</accession>
    <name>A0A1W1I9U7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NSJP_3524</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3524"/>
    <dbReference type="EnsemblBacteria" id="SLM49691">
        <property type="protein sequence ID" value="SLM49691"/>
        <property type="gene ID" value="NSJP_3524"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3524"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPt" evidence="9">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="9">
        <location>
            <begin position="152"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="9">
        <location>
            <begin position="328"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="637"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="8">
        <location>
            <begin position="843"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="1011"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="471"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="982"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="989"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM49691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1136" mass="123607" checksum="B5EEC77229ABA82B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9V9</accession>
    <name>A0A1W1I9V9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fn3_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3396"/>
    <dbReference type="EnsemblBacteria" id="SLM49563">
        <property type="protein sequence ID" value="SLM49563"/>
        <property type="gene ID" value="NSJP_3396"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3396"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012800048" description="fn3_3 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="fn3_3" evidence="2">
        <location>
            <begin position="223"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="313" mass="34865" checksum="47850BB73C291BAA" modified="2017-06-07" version="1">MRITRRVSSGMMALVLGFATPVLASYEAMTVSDGGAITGTVKLDGTVPKPKGYNLTTLPDPFYCGRISDGQGWRILQPFNVGPAGEFRDVVVYVEGIDRGKPFDDAGAPQIEAKDCLFLPFTTVVRDDQSVTVVNMDPVMHDIQAYETSHLGARVLFNVPLPMNPQHPRNFKDRSEIGLYHKHMAGPPMKQLVNLSKGRRIFMMQCGFHVYMESWGLAVTNPYFAKTDEQGRFTITDVPPGTYKLSVWHPYIRTVIEQTVTVEPKGTAEAGLVVLAPTGRLYANEVLDHEYVRYSVTEDAKKEIEPMIQKQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA01</accession>
    <name>A0A1W1IA01_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49709">
        <property type="protein sequence ID" value="SLM49709"/>
        <property type="gene ID" value="NSJP_3542"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3542"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="156" mass="18101" checksum="E09B032AC5B18CD0" modified="2017-06-07" version="1">MMPIDESTYGAKPLDEDRFDYHVWKAEGLSLGGPGRDAAVEQAVQSARNKLGPGWELDHINHGTVVPPQLVFRKAMPETVLHRRYKNYDVWSSPSQFDSDGTYLRVVKIRNQQRTWTRRIVHEHESRYTTIEEAHAEGFVLAHRIIDEAERNPYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA73</accession>
    <name>A0A1W1IA73_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49924">
        <property type="protein sequence ID" value="SLM49924"/>
        <property type="gene ID" value="NSJP_3757"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3757"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="96" mass="10805" checksum="6BD2A961ECFAB773" modified="2017-06-07" version="1">MSRFSGHCVVMGVKARPSQDGKRIFRNAVLYFEEDTSTLEASISDDHEHLYKLMEANKMKPCQITVNLREFKGQRFLDVTGYQPGLAAPGTKGPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAC6</accession>
    <name>A0A1W1IAC6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_3807</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49974">
        <property type="protein sequence ID" value="SLM49974"/>
        <property type="gene ID" value="NSJP_3807"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3807"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="357"/>
            <end position="358"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="617" mass="70898" checksum="B871C6A31FA91802" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAQ6</accession>
    <name>A0A1W1IAQ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49853">
        <property type="protein sequence ID" value="SLM49853"/>
        <property type="gene ID" value="NSJP_3686"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3686"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="180" mass="20516" checksum="800C5CFA93C16452" modified="2017-06-07" version="1">MPFGQFNRDSFRTREKHQLSIVKVHHLVSQDHAPVDQPPDFSVQVRDREADMIEAGLCEILDVRFRQLLRLEIPQELDLEPGFLRRHQRDVFRLDLRHAHVAGKSIAGNHHGLVLDEPQKTKKSFGLGEVPYYYRHVVNVQNHGSPLSNTTCARVETPVGYCAQAHVSTHSQECGLLNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAU2</accession>
    <name>A0A1W1IAU2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative Ferric iron uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_3949</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3949"/>
    <dbReference type="EnsemblBacteria" id="SLM50116">
        <property type="protein sequence ID" value="SLM50116"/>
        <property type="gene ID" value="NSJP_3949"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3949"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030148">
        <property type="entry name" value="Fiu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF68">
        <property type="entry name" value="PTHR32552:SF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07660">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0798">TonB box</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="STN" evidence="10">
        <location>
            <begin position="71"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM50116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="852" mass="93886" checksum="95DDE0B3CF50141B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAU7</accession>
    <name>A0A1W1IAU7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50019">
        <property type="protein sequence ID" value="SLM50019"/>
        <property type="gene ID" value="NSJP_3852"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3852"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="188" mass="20814" checksum="F55C0429E930AEC3" modified="2017-06-07" version="1">MSQPRGILSQLAGGGVALILIVGLAACGGPPKWVKQGSGAMSEKDSKAFFGVGSVTGVRNEPLAWDTAENRGRAEIAKTFETYTGYLMRDYAASTTAGDFTRMSEEQNVERAIKTITTTTLSGVRPIDRYKDEKTGTYYVLTKLNLEDMKNNLEHAKELNAEVRDYVRKNADKAFERLEKEEDKRANH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAX3</accession>
    <name>A0A1W1IAX3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50164">
        <property type="protein sequence ID" value="SLM50164"/>
        <property type="gene ID" value="NSJP_3997"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3997"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="63" mass="6949" checksum="8F5357D3A9A5F36E" modified="2017-06-07" version="1">MGIQTCLARTGGHFTDVSYASERVTQSDAESGFNLVSGHQGMKPRPCQYVERTCVRMSLTRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAZ5</accession>
    <name>A0A1W1IAZ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Regulatory protein, SyrP-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3902"/>
    <dbReference type="EnsemblBacteria" id="SLM50069">
        <property type="protein sequence ID" value="SLM50069"/>
        <property type="gene ID" value="NSJP_3902"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3902"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="2">
        <location>
            <begin position="53"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="341" mass="38150" checksum="CC09475D9205AC84" modified="2017-06-07" version="1">MHVNHNDAGPVTMDDASGAATGLRACAVGRLDADTPLPVVVTPTERLPLAGYQDDIDRVIGAHLSTVGGILFRGFPVDSAADFEAMVKRISPDLASYEFGSTPRSQVHNQIYTSTEYPPHQHIPLHNEQAYTTEWPMKIWFYCAQASPEGGYTPIADSREMYRHIPARIRDRFVEKGVMYVRNYGNGLDVPWTKVFNTMDRGVVERFCRAAEIAYEWKPDGELRTRQVCQAVAVHPRTGETVWFNQAHLFHVSNLESAVREALLSVVSEADLPRQACYGDGTPIDTAVLDEIRDVYRCHAVQFPWQRGDVLMLDNMLAAHGRTPFKGPRKILVAMAESSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB21</accession>
    <name>A0A1W1IB21_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4061"/>
    <dbReference type="EnsemblBacteria" id="SLM50228">
        <property type="protein sequence ID" value="SLM50228"/>
        <property type="gene ID" value="NSJP_4061"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4061"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="4"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="398" mass="44230" checksum="292171ACEE14FC72" modified="2017-06-07" version="1">MHSDFLVIGGGVIGLNIARGLRKFYPDSSVHLLEKEAACGLHASGRNSGVLHAGFYYSPESLKARLTWRGNRQLTEYCERKNIPLNKCGKLVVARNVEDHAGLDELLRRGRANGIPLEEISEKEAKSIEPRVKTCGRALFSPATATVDPTEVMQAMKKDATEEGVQIWCGVRYLGRERGKVKTTQGTREAGYVVNAAGLYADRIARDYGFSSRYRILPFKGLYLYSSEPPGSIRTNIYPVPDLKNPFLGVHFTVGAGGKAKIGPTAIPGFWREQYGWTENFHLNEFLEVAVRGLGLLVNSNFDFKSLAVRELAKYSKSKMIALASLLAEGVKPDHYQQWGKPGIRAQLVDIEKRKLEMDFVLEGDRSSMHVLNAVSPAFTCSIPFSEHVCEHIRTVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB45</accession>
    <name>A0A1W1IB45_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="15">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="15">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15 19" type="primary">glmU</name>
        <name evidence="19" type="ORF">NSJP_4091</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="15"/>
    <dbReference type="EC" id="2.3.1.157" evidence="15"/>
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        <property type="protein sequence ID" value="SLM50258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1325564.NSJP_4091"/>
    <dbReference type="EnsemblBacteria" id="SLM50258">
        <property type="protein sequence ID" value="SLM50258"/>
        <property type="gene ID" value="NSJP_4091"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4091"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
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    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:magnesium ion binding"/>
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        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
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        <property type="term" value="P:cell morphogenesis"/>
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        <property type="term" value="P:lipid A biosynthetic process"/>
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    <dbReference type="CDD" id="cd03353">
        <property type="entry name" value="LbH_GlmU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bifunctional_GlmU"/>
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        <property type="entry name" value="GlmU_C_LbH"/>
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        <property type="entry name" value="Hexapep"/>
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        <property type="entry name" value="Hexapep_transf_CS"/>
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        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01173">
        <property type="entry name" value="glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14 15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 15 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="164"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
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        <location>
            <begin position="103"/>
            <end position="104"/>
        </location>
    </feature>
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        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="282"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="15">
        <location>
            <begin position="417"/>
            <end position="418"/>
        </location>
    </feature>
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        <location>
            <begin position="488"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="132"/>
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        <ligand>
            <name>Mg(2+)</name>
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        <location>
            <position position="169"/>
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        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
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        </ligand>
    </feature>
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        <location>
            <position position="185"/>
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        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
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        <location>
            <position position="200"/>
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        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
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        <location>
            <position position="364"/>
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        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
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        <location>
            <position position="382"/>
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        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
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            <position position="397"/>
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        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
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        <location>
            <position position="408"/>
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        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
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        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
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        </ligand>
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        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
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        </ligand>
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            <position position="454"/>
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        <ligand>
            <name>acetyl-CoA</name>
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            <position position="471"/>
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        <ligand>
            <name>acetyl-CoA</name>
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    </feature>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_01631"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="SLM50258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="516" mass="54798" checksum="57E96DA7FAE35DBF" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZQ3</accession>
    <name>A0A1W1HZQ3_9BACT</name>
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        <submittedName>
            <fullName evidence="10">ATP-dependent RNA helicase RhlE</fullName>
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        </submittedName>
    </protein>
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        <name evidence="10" type="primary">rhlE</name>
        <name evidence="10" type="ORF">NSJP_0066</name>
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        <name type="scientific">Nitrospira japonica</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
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            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
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        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016787">
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="Helicase_C"/>
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        <property type="entry name" value="SSF52540"/>
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        <property type="entry name" value="HELICASE_CTER"/>
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    </dbReference>
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        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
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        <location>
            <begin position="33"/>
            <end position="208"/>
        </location>
    </feature>
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        <location>
            <begin position="219"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="381"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
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        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM46238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="430" mass="47370" checksum="1AC5A209D14458D2" modified="2017-06-07" version="1">MSKFVQMNLPPFLAQRLQQAGITAPTPIQQAAVPPALEGRDVMAQAKTGSGKTLAFLLPMIERALRPAAGPAQGRCPQYLILAPTRELALQIEMELRKYAPPSVTSLAVYGGTPIERHYRALKRPPLVVVGTPGRLLDLAGSGHLHLGAVTWLVMDEADQMLDRGFLRDIQRILGLLPRERQTLLFSATFSPEIQELARSMQRDPARISVDPGVSSPTTITHAYYVVPAEQSRTQLVHTLLQSVKAGERSMVFCDQKYKVRRLAAKLGGDPASVGSITGNHSQAQRERTLGAFRSGRLRSLVATDVAARGLDIPDVAQVIHYELPSNPNSYVHRTGRTGRAEKEGATYLILSESEEREYLRMVRQLRIQTKKLPLPTFVSLPPAAALPNGEPQAPPRHRRRNEQFHRTNGNSDGLHRRAASPVRSSGYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZX2</accession>
    <name>A0A1W1HZX2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46272">
        <property type="protein sequence ID" value="SLM46272"/>
        <property type="gene ID" value="NSJP_0100"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0100"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="283" mass="33142" checksum="FA8A26B69586C406" modified="2017-06-07" version="1">MLVAGLWDGGRDAHALEKYGRPLPEFEKSDGDKSKQDFDESLIAGYFLAAAFVSNPTFAARPDNTGLVGMRYMAHLETDLYKKYLTAYTDQNFFSDREKGWIILTEWDQTYGMTGTVNHWSWRTQYERDAPLDKSGLIQAYADGLVNYRVRSHEDWSWWQKTFPKNTLTAYAGMGWLYYNQTYFARPDNTGRALFRYVGHVDLDLYKQKVVFYGDFNMFTDRTASNVVRPSELDWILGIAVRWRDYEVSVYREQDLPLDRGGLIQEYWAVQLRYAFDVQKQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZY9</accession>
    <name>A0A1W1HZY9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46318">
        <property type="protein sequence ID" value="SLM46318"/>
        <property type="gene ID" value="NSJP_0146"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0146"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012212946" evidence="1">
        <location>
            <begin position="30"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="210" mass="23946" checksum="B21EEA19757067B7" modified="2017-06-07" version="1">MRSACAKTSRYLGLVLAMTLCLTTSAGSAQPESSPVTPDFSGSLVRQVNGQRHQAQIFSKGNRLRLEYKYAVRTDHGYAAIEIIRLDLGEAWYVLAQQKELLIMPLDADDVLPFQSELSGERERVLVGDATAAGRPTRLYEVQTEKDGRVERFYEWVDVETGIVLKLVSRDRDWTFEYQRIRFSPQPSFYFDEPPGYRKRSIGTTKKRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I038</accession>
    <name>A0A1W1I038_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0198"/>
    <dbReference type="EnsemblBacteria" id="SLM46370">
        <property type="protein sequence ID" value="SLM46370"/>
        <property type="gene ID" value="NSJP_0198"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0198"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="2">
        <location>
            <begin position="71"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="223" mass="24541" checksum="312169FA202777F4" modified="2017-06-07" version="1">MRRKIFIGGFIVAITLVGCSSMQRERGGPAPATTQDCCRSADVAPSRSAIVRSAAKLVGARTVEVNGHRIHYDCAGVTRAVFLEHGIDLYESRTTDRHANGVRLIYNHIREYGRLHQGPAVRPGDLVFFDNTWDSNSDGKMNDPLTHVGIVERQDRDGTIVFISRVAGAVERYRMNLGLPHVHRAADGKILNDHLRRKDTGTADQTGYLTGELFAGFGTRTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I059</accession>
    <name>A0A1W1I059_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Octaprenyl-diphosphate synthase</fullName>
            <ecNumber evidence="3">2.5.1.90</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ispB</name>
        <name evidence="3" type="ORF">NSJP_0209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.90" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0209"/>
    <dbReference type="EnsemblBacteria" id="SLM46381">
        <property type="protein sequence ID" value="SLM46381"/>
        <property type="gene ID" value="NSJP_0209"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0209"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106350">
        <property type="term" value="F:octaprenyl pyrophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="334" mass="37120" checksum="B9479A31A2E13955" modified="2017-06-07" version="1">MPQGPVISSIQTMADVWDAYRRELEGVEDQVRKNLDSSVTLVNTVAAHILNSGGKRIRPLLLLLSAQLCGYAGRDHHQLGSLVEFIHTATLLHDDVVDDADLRRGRRTARKVWGNQISILVGDYLYSKAMCQVVEFRSQGINEVLAEACKKMAEGEVLQLYYNGNPAMPEADYLKVVEHKTAGLIAAACRMGAILADASEPQQDALFRFGQYLGIAFQVADDTLDYTANGDSLGKTLGQDLRQGKATLPLLHLLQHCSESDRQMIKDRMETRTLNDDDLTRLLHLMEDYGSITYALDRAQDYIAAAKRDLSSFEDSPAKRALSVAADYMVTRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0A6</accession>
    <name>A0A1W1I0A6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0249"/>
    <dbReference type="EnsemblBacteria" id="SLM46421">
        <property type="protein sequence ID" value="SLM46421"/>
        <property type="gene ID" value="NSJP_0249"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0249"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="566"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="673" mass="76231" checksum="56A8300D980C6E37" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0C1</accession>
    <name>A0A1W1I0C1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46448">
        <property type="protein sequence ID" value="SLM46448"/>
        <property type="gene ID" value="NSJP_0276"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0276"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013094113" evidence="1">
        <location>
            <begin position="19"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="90" mass="9510" checksum="45BC760FD68CA003" modified="2017-06-07" version="1">MKSFILLLVSITSASCISAPRTEFTGSDGKLIAAVSCNGWFQTMDDCRQYANDVCSAGYEPIQLASGTDTVSKRGGLGDVPAQKLTIACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0H7</accession>
    <name>A0A1W1I0H7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46491">
        <property type="protein sequence ID" value="SLM46491"/>
        <property type="gene ID" value="NSJP_0319"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0319"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004658">
        <property type="entry name" value="OMP_Slp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03843">
        <property type="entry name" value="Slp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="182" mass="20312" checksum="01651CE3794DEB74" modified="2017-06-07" version="1">MRQFQKTLIRRAVGCLSLLVVAGIAFGCSPVPRKYIRAAAPNVTLAKLSAAPDVYRDRLVVMGAVILEEETKDGNLWLHVKNRPLDQDYRPQLPPSVDDPEAGWYWVVVSNHQSFPTSYRHWADMTVVGRVNGLGPGKEPILMMVYARGWGLKSGGESVWENFTDANYIPFTPEEVVGEGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0L1</accession>
    <name>A0A1W1I0L1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46535">
        <property type="protein sequence ID" value="SLM46535"/>
        <property type="gene ID" value="NSJP_0363"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0363"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="56" mass="6157" checksum="1FB76D29BFCC9B97" modified="2017-06-07" version="1">MKLWLNRGEETVDSTEGTRDEMDSGSANAPAGAHGDDDPVRYRHRDVVLARVCSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0V9</accession>
    <name>A0A1W1I0V9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46640">
        <property type="protein sequence ID" value="SLM46640"/>
        <property type="gene ID" value="NSJP_0468"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0468"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="77" mass="8763" checksum="7F392A5933D62B90" modified="2017-06-07" version="1">MREAARRRTAIMCAEAVPWRCHRLLIADVLLSLGWSVRHIFSDIDLQPHKLTSFARLEAGRVTYPAPSDSTETPNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0W2</accession>
    <name>A0A1W1I0W2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABC_trans_aux domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0311"/>
    <dbReference type="EnsemblBacteria" id="SLM46483">
        <property type="protein sequence ID" value="SLM46483"/>
        <property type="gene ID" value="NSJP_0311"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0311"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005586">
        <property type="entry name" value="ABC_trans_aux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03886">
        <property type="entry name" value="ABC_trans_aux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC_trans_aux" evidence="1">
        <location>
            <begin position="41"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="214" mass="23791" checksum="AACBCCA52855FD35" modified="2017-06-07" version="1">MTARDVKTKVLCAVIVPLMLGGCVNLNKSYPEKRSFALDVGSDHQPTPTAGSAVLRVSRFRVSPLFAGRAMVYRVGELQYDNDFYNEWLVSPSVLLTQQVQGWLSKSNRFRFVLTGMNHVEPTHVLDATVTEFYGDYRSGGSPQAVLGVEIMLLIDDRKDETVLFRRSYRQEVPLAGRAPDALAAGLSQAARQVLIDFDRDLDGVSLEPSPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0W4</accession>
    <name>A0A1W1I0W4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Thiosulfate sulfurtransferase GlpE</fullName>
            <ecNumber evidence="2">2.8.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.8.1.1" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0474"/>
    <dbReference type="EnsemblBacteria" id="SLM46646">
        <property type="protein sequence ID" value="SLM46646"/>
        <property type="gene ID" value="NSJP_0474"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0474"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="16"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="106" mass="11840" checksum="6CAA389D98FFA8B4" modified="2017-06-07" version="1">MSFMITPQELKTRLDNKDPMVLLDVREQWEYDLAKINGSVLIPLSTLPHSLSRLDRNSEIIAICHHGMRSADATGFLAQQGFTKVKNLVGGIDAWSAQVDGTVPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I103</accession>
    <name>A0A1W1I103_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0506"/>
    <dbReference type="EnsemblBacteria" id="SLM46678">
        <property type="protein sequence ID" value="SLM46678"/>
        <property type="gene ID" value="NSJP_0506"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0506"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="240" mass="27348" checksum="392E699BF828E8D1" modified="2017-06-07" version="1">MNRLEWIIIGLVSWMLVDAGHAVAQRNDMPVGYPQTLERELQLLLEEVRKGKPSPSLLVKLSETYFDMADDMLTDETKRLAAYDAGAEAAKQAFEMDERLADAHFFHALNIGSAARLRGVTNAAFAVKEIKYCAQRAIELDPQHSQALQMMGGLLMEIPWILGGSDKKAQDYLERSVAADGNFANARIMLAKLYLKQGRREEAKRQLEAVMHFDRPHYRYTWERKYKAEAERMLKELGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I136</accession>
    <name>A0A1W1I136_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atoB</name>
        <name evidence="7" type="ORF">NSJP_0546</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0546"/>
    <dbReference type="EnsemblBacteria" id="SLM46718">
        <property type="protein sequence ID" value="SLM46718"/>
        <property type="gene ID" value="NSJP_0546"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0546"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="8"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="273"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="394" mass="41321" checksum="3A305C16CBE4BD2A" modified="2017-06-07" version="1">MSTSQRAVIVSAVRTPIGSFNGALSPVPATRLGSIAIAEALKRIDMPPDRVDDVYMGCVLGAGLGQAPARQASIGAGIPHSVGATTVNKVCGSSLQTVIMAARSVALGEARIVVAGGMESMTRAPYLLEKARQGYRLGHAELVDSLVKDGLWDVYNNFHMGQAGELCAAKYQLTRRELDDFALESYRRAKEAIATGSFRREIVPVETPQRKGAPAIVTDDEEPNRGDLGKLRDLKPVFQEDGVLTVGNSPSCNDGAAAVVVMAEAEAARLGLTPMARIVGYAGAALAPEWFTIAPVEAIARALKTTGLSIGDIDLFEINEAFSVVSLAVNRELGLDFKKVNVNGGAVALGHPIGATGARILTTLLYAMEVRGARRGIAGLCIGGGEALAMVVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I160</accession>
    <name>A0A1W1I160_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46732">
        <property type="protein sequence ID" value="SLM46732"/>
        <property type="gene ID" value="NSJP_0560"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0560"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="174" mass="19788" checksum="64CBCBCFFF803EFB" modified="2017-06-07" version="1">MSLTAILFAMARKTSVILQVIAFSIVVLPMTAKAQPPSYQETISWIRETMQSSASEHTSEHSFNVRNVKFDSCKMSWVSENTVYHLGLNNNESGLAQVEVFLDFSAIPTDSIQDTSYSIDFPPSLTKTNCRTAPDHHYLCRTKVSWIRIPDASVRTRMLEAFRHLSMMCFKQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I169</accession>
    <name>A0A1W1I169_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46737">
        <property type="protein sequence ID" value="SLM46737"/>
        <property type="gene ID" value="NSJP_0565"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0565"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="111" mass="12125" checksum="24CE5835F55122CF" modified="2017-06-07" version="1">MIECRQHPRVTVDMQVYFSTTGNKLIREGTMFDLSVGGCAVASTTSVQSGSAVRILIRATDLGSPITIESAAVRWSEHGEFGVEFIGVSDVDHHRLRRLLQATNVSHVQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I176</accession>
    <name>A0A1W1I176_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46756">
        <property type="protein sequence ID" value="SLM46756"/>
        <property type="gene ID" value="NSJP_0584"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0584"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="70" mass="7904" checksum="2462E4B09B816FCD" modified="2017-06-07" version="1">MRTVSAERRRNLSICLQDQLLSSRAGLALDVPTLEGLSVQTYRKSADNVTRRRTVRVRADDAMGWIMPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1A1</accession>
    <name>A0A1W1I1A1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46780">
        <property type="protein sequence ID" value="SLM46780"/>
        <property type="gene ID" value="NSJP_0608"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0608"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="61" mass="6890" checksum="854417D3B569C413" modified="2017-06-07" version="1">MNFRQFRSPSNDHGRMVKINGRMVGGRGFRLQSKIGRGAVELGRLERLLIEARRPKPTAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1B9</accession>
    <name>A0A1W1I1B9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46782">
        <property type="protein sequence ID" value="SLM46782"/>
        <property type="gene ID" value="NSJP_0610"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0610"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="46" mass="5181" checksum="45A272BD5B6F6F1C" modified="2017-06-07" version="1">MKMDRIVIQIPAKLKAKLDAERRQGTTASGLIRFLLENHFSGKRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1G9</accession>
    <name>A0A1W1I1G9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lipid A export ATP-binding/permease protein MsbA</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">msbA</name>
        <name evidence="10" type="ORF">NSJP_0501</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0501"/>
    <dbReference type="EnsemblBacteria" id="SLM46673">
        <property type="protein sequence ID" value="SLM46673"/>
        <property type="gene ID" value="NSJP_0501"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0501"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="335"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="368"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM46673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="576" mass="63663" checksum="7103798BA00694E6" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1K4</accession>
    <name>A0A1W1I1K4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Glycosyl transferase, family 39</fullName>
            <ecNumber evidence="9">2.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_0716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0716"/>
    <dbReference type="EnsemblBacteria" id="SLM46888">
        <property type="protein sequence ID" value="SLM46888"/>
        <property type="gene ID" value="NSJP_0716"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0716"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="PMT" evidence="8">
        <location>
            <begin position="37"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="581" mass="64063" checksum="E4EAF58472657918" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Q0</accession>
    <name>A0A1W1I1Q0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46753">
        <property type="protein sequence ID" value="SLM46753"/>
        <property type="gene ID" value="NSJP_0581"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0581"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="111" mass="12130" checksum="6E5D372524DB7F1C" modified="2017-06-07" version="1">MSGTVLDVSDENYKDFVNGPGSVVAYGLATCEPCKTYDPILEEIAARFPTVKVGKAKMHVPGRCREIKKTHVFETYPTTHLFANGKLLLTREGVIEPAELAALISDHLLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1R3</accession>
    <name>A0A1W1I1R3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Threonine synthase</fullName>
            <ecNumber evidence="6 10">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">thrC</name>
        <name evidence="14" type="ORF">NSJP_0749</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6 10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0749"/>
    <dbReference type="EnsemblBacteria" id="SLM46921">
        <property type="protein sequence ID" value="SLM46921"/>
        <property type="gene ID" value="NSJP_0749"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0749"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="25"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="11">
        <location>
            <begin position="189"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM46921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="352" mass="37142" checksum="343AA83E5374A157" modified="2017-06-07" version="1">MKPWRGLIEEYRKFLPVTEHTPVVSLGEGHTPLIRAAKLAKKIAPGIDLYLKVEGANPTGSFKDRGMTMAISKALEGGAQAVICASTGNTSASAAAYGARAGLAVYVLIPAGKIAMGKLSQAMMHQATVIQIDGNFDQALSIVKEVSALHHIELVNSLNPYRIEGQKTAAMEVCDQLGDAPTLHVLPVGNAGNITAYWKGYQEYRAANQTTRSPRMMGFQAAGAAPMVLGHIVENPQTVATAIRIGNPASWQAASDVIRDSSGFIDSVLDEEILQAYTMVAGTEGVFCEPASAASVAGVIKLSRQGALREGDTVVCTLTGHGLKDADTAISVSVQPKTVQATKEDVARFLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1X1</accession>
    <name>A0A1W1I1X1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative general secretion pathway protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_0838</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0838"/>
    <dbReference type="EnsemblBacteria" id="SLM47010">
        <property type="protein sequence ID" value="SLM47010"/>
        <property type="gene ID" value="NSJP_0838"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0838"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005644">
        <property type="entry name" value="NolW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038591">
        <property type="entry name" value="NolW-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03958">
        <property type="entry name" value="Secretin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012144917" evidence="5">
        <location>
            <begin position="20"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Secretin_N" evidence="6">
        <location>
            <begin position="130"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="505"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="533" mass="57751" checksum="C08366E5207EC39F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2A6</accession>
    <name>A0A1W1I2A6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_0939</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0939"/>
    <dbReference type="EnsemblBacteria" id="SLM47111">
        <property type="protein sequence ID" value="SLM47111"/>
        <property type="gene ID" value="NSJP_0939"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0939"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="196" mass="21890" checksum="A48781AFF5C78613" modified="2017-06-07" version="1">MSTMRGIAGWMIVLACLSGCGYNDLQGLDEDTKAAWSEVVNQYQRRADLIPNLVATVKGYAGHEKDTLEKVVQARAQATGVQITPETLNNPEAFERFQNAQAGLTSALGRLIAIAENYPNLKADQNFRDLQSQLEGTENRIAVARKRYIDRVAEYNKMVRYFPTNLTAKFLLHLEERPNFAVADEKSVATPPPVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2B7</accession>
    <name>A0A1W1I2B7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0976</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0976"/>
    <dbReference type="EnsemblBacteria" id="SLM47148">
        <property type="protein sequence ID" value="SLM47148"/>
        <property type="gene ID" value="NSJP_0976"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0976"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="27"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="235"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="482" mass="53342" checksum="2BEBB88D50800673" modified="2017-06-07" version="1">MEMTTNWMELAELALARIRAAGAEYGDVRVQHSLTQSLEGEDRRIASIQDVEDTGFGIRVLYHGGWGFAASSVFSLEEVPRVADLAVEIARGSSSLAREKVVLVDEPVHRASIATPFRIDPFGVPLERKTDLLCELMEYVHRQAEVVRSRAALWARRDRKLFMSTEGSRLEFDLLAVQGEFTAVARHDGRFASRSFNTPSLRTGYELIEDAALLAEAPRVAAQAAEKVRAPAVEPGRYDLVLDAEHLSLTMHESCGHPSELDRALGYEANYAGTSFLTPDKRGTFRFGSPSVTLVADNTEPETLAATGYDDDGVACQKWDIVRDGLFVGYCTNRETASKIGETRSRGSNRAEGWGSVPIVRIANIGLEPGSASLDDLIGDIKKGIYIEGHGSYSIDQRRYNFQFGGDAFWLIEHGKRTHMLRDVIYHGITPEFWGRCDGVADRTHRRRFGFITCGKGQPGQSGWMTHAASPARFRQVDVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2M4</accession>
    <name>A0A1W1I2M4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4412 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47225">
        <property type="protein sequence ID" value="SLM47225"/>
        <property type="gene ID" value="NSJP_1053"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1053"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025524">
        <property type="entry name" value="DUF4412"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14371">
        <property type="entry name" value="DUF4412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4412" evidence="2">
        <location>
            <begin position="26"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="274" mass="30363" checksum="EDDBA5A416EC9093" modified="2017-06-07" version="1">MRAIVALLVATVAVWPSTEPASAGEFEGILHMTTTHVDETPTKMDWMIKGDKARIERPRMDGRTQVMILDSKTKTMLILFPERKAYAEIGLGGEHGERISKAVEDYEVERTGKTDKVAGRSCEVWRVKEKEADAEKHEICVAKGFGRTASFWMEPMKTQPPWVTQLINEGGFGLRSIRYDSTGQASTTTEVTNIEAKSLDAALFAPPAGYQKMDRGAMAMAGAMGGEDVQKRIEEMKKRRAGRDGSSTGAKPDMSEIIKQFGERMKKQQQEAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2S3</accession>
    <name>A0A1W1I2S3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase, family 15</fullName>
            <ecNumber evidence="3">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1120"/>
    <dbReference type="EnsemblBacteria" id="SLM47292">
        <property type="protein sequence ID" value="SLM47292"/>
        <property type="gene ID" value="NSJP_1120"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1120"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="6"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="218"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="594" mass="66861" checksum="7D9E726AF013EC0D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Y8</accession>
    <name>A0A1W1I2Y8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Hemerythrin HHE cation binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47331">
        <property type="protein sequence ID" value="SLM47331"/>
        <property type="gene ID" value="NSJP_1159"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1159"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="2">
        <location>
            <begin position="126"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="204" mass="22794" checksum="C92B9E9EE06B2181" modified="2017-06-07" version="1">MAKRMPKQSPDEQRKPSQPVNAVQLLKADHRHVQKLFEQFKAAPAGDKASLAARLFVFLDVHGRIEEELVYPAVRASMESSASIQAHDASDQGDDGEDAEMAPLNGVELDLPEEDDEESDGAVAMAYESHQIIRDLIQQLRSIETDHDDYHELFDELEEVVIEHVAEEENEILPLLADTSDIRALGSELQRRKDELTSRASLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3B7</accession>
    <name>A0A1W1I3B7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like sulphurtransferase</fullName>
            <ecNumber evidence="2">2.8.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.8.1.1" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1293"/>
    <dbReference type="EnsemblBacteria" id="SLM47465">
        <property type="protein sequence ID" value="SLM47465"/>
        <property type="gene ID" value="NSJP_1293"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1293"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="47"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="141" mass="15368" checksum="8EB7BFAC724C9A55" modified="2017-06-07" version="1">MRTRLATCMAWTVAVFVLTIGTVSADHSYLLTVQQLRAGLNKAGSPDRKGFVLIDVRSPEEHAGGYIPGTDFNIDFREIKARHRELGADYGDHIVVYCQSGRRSGIAAEALADLGYTRVYNVSGSMNAWMEAGYPIASAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3B9</accession>
    <name>A0A1W1I3B9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">priA</name>
        <name evidence="13" type="ORF">NSJP_1312</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1312"/>
    <dbReference type="EnsemblBacteria" id="SLM47484">
        <property type="protein sequence ID" value="SLM47484"/>
        <property type="gene ID" value="NSJP_1312"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1312"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041236">
        <property type="entry name" value="PriA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18074">
        <property type="entry name" value="PriA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00595">
        <property type="entry name" value="priA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PriA_3primeBD" evidence="11">
        <location>
            <begin position="19"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PriA_C" evidence="12">
        <location>
            <begin position="659"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM47484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="766" mass="83907" checksum="3B59D73CE10E22EB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3E9</accession>
    <name>A0A1W1I3E9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-N-acetylglucosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nagZ</name>
        <name evidence="3" type="ORF">NSJP_1319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1319"/>
    <dbReference type="EnsemblBacteria" id="SLM47491">
        <property type="protein sequence ID" value="SLM47491"/>
        <property type="gene ID" value="NSJP_1319"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1319"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="2">
        <location>
            <begin position="7"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="375" mass="40306" checksum="D743DFF4F2EB3511" modified="2017-06-07" version="1">MARPHLTVREKIGQLFMIGFMGTSVTPDLAEFLRTYKPGGVILFSRNLESVGQIVELTNDLQQCNPKSPLLISIDQEGGRVSRLPAGFTIFPPCEVLGRCNSAELTYAAAATIAKELRAVGINMNMAPVLDVNSNPDNPIIGDRAFGTTPDLVSEAGILTAAGLQDNLVVACGKHFPGHGDTAADSHKELPVVEAGRERLDAVELAPFRRAAAAGVAAMMTAHVLYKALDAQRPATLSPLIITGLLRDQLRYDGVVLTDDLEMNAIVDHYGIADAAVRAVQAGCDVLLICKDQAREVEAFEAIEQSVAAGDITMDRLDQSVARIQRVKQRYVVPYRPVSISEARLVAGCRTHRALLQSVHQTGARMAKAAIPQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3H6</accession>
    <name>A0A1W1I3H6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rplI</name>
        <name evidence="9" type="ORF">NSJP_1221</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1221"/>
    <dbReference type="EnsemblBacteria" id="SLM47393">
        <property type="protein sequence ID" value="SLM47393"/>
        <property type="gene ID" value="NSJP_1221"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1221"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="8">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="158" mass="17472" checksum="807F58528E546C69" modified="2017-06-07" version="1">MKVILQETMDGVGHLGDLIDVKDGFARNFLLPRKKAVVANDRNIKSFEHAKRVAADRAKKEKLEIEAHAKKLSTVTLTVEAQVGKDDKMFGSVTVKDIAEGLAEQGYQVDRRKIQLPHPIKELGSFTVPVKMPREVTAAVTVRVVKRQEAEPASDSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3L8</accession>
    <name>A0A1W1I3L8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase, GCN5-related</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1426"/>
    <dbReference type="EnsemblBacteria" id="SLM47598">
        <property type="protein sequence ID" value="SLM47598"/>
        <property type="gene ID" value="NSJP_1426"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1426"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="143" mass="16744" checksum="826AE4FC1E2F9B16" modified="2017-06-07" version="1">MPSSLKTALVFSDKKDLQTAQLLGLFHQAPWAKDRTLEDAKDMLRHTDLILSAWDGEHLVGFGRVLTDFVYRATIWDVIVDKAYQKQGIGTEIVQRILHHPRLRRVELFWLCTRRPAFYEKMGFSAREQTGMVWSRSKQIRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3P8</accession>
    <name>A0A1W1I3P8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="9">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">thrS</name>
        <name evidence="12" type="ORF">NSJP_1456</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1456"/>
    <dbReference type="EnsemblBacteria" id="SLM47628">
        <property type="protein sequence ID" value="SLM47628"/>
        <property type="gene ID" value="NSJP_1456"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1456"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="11">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="240"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM47628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="642" mass="71909" checksum="4F6C957218A0DC38" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Y5</accession>
    <name>A0A1W1I3Y5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative D-alanyl-D-alanine carboxypeptidase</fullName>
            <ecNumber evidence="10">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NSJP_1489</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1489"/>
    <dbReference type="EnsemblBacteria" id="SLM47661">
        <property type="protein sequence ID" value="SLM47661"/>
        <property type="gene ID" value="NSJP_1489"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1489"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase_S11" evidence="9">
        <location>
            <begin position="62"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="305" mass="33085" checksum="8E902480BCB8D40F" modified="2017-06-07" version="1">MRVRNTGPIPRPRLGATVLLLGILITGLAGVMPSTVEGKRTSVSPRSNHVSGVDGTTLPWRRVPAHSILLKELNSGRVLYEHESAKRLSPASLTKIMSALVILERGHLDDLVTVSPTAARAHKIHLRLKPGQVFTLEDLLKGMLIMSANDACLAAVEHVGGDESQFVSLMNAKAAALGLSDTHFNNGCGFDHPNHYSTAEDLARLSVIALEQPTFRRLVREERAIIMPINGTHAHVLHTTNRLLGRIPGVEGVKTGFTSKAGRCLIAKVSQNGSDLLLVILNSNRRWNTAMSLINYGLRTSDPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Z7</accession>
    <name>A0A1W1I3Z7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47724">
        <property type="protein sequence ID" value="SLM47724"/>
        <property type="gene ID" value="NSJP_1552"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1552"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="205" mass="22511" checksum="BB464C8922A70961" modified="2017-06-07" version="1">MVLAGLFAGVLCLGLILGDWLYFIRLTPDAIRYGCGIARSLDQFPADRVVHVSRRFDANGVLSLPHGIARYYPELRQIAIRPQYHLFSMSFRTAWPLKGLVHLSADAPQATAVCVKRIPWSSAIITLVWFLLVSLGTAAFLVTYALQGGFNSFTGVLMGTGILGIGLLVLAFGAVTVVFSYRLENSRLMKVYGELLDDAENSLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I421</accession>
    <name>A0A1W1I421_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Argininosuccinate lyase</fullName>
            <shortName evidence="5">ASAL</shortName>
            <ecNumber evidence="3 5">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">argH</name>
        <name evidence="8" type="ORF">NSJP_1529</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1529"/>
    <dbReference type="EnsemblBacteria" id="SLM47701">
        <property type="protein sequence ID" value="SLM47701"/>
        <property type="gene ID" value="NSJP_1529"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1529"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="19"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="7">
        <location>
            <begin position="377"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="468" mass="52500" checksum="E60E39325EEF446D" modified="2017-06-07" version="1">MAGRGNRQRRAAAGKAWEGRFREKTNRLVEAFTGSVGVDGRMYAEDIQGSIAHCKTLRKAGVLSAADTTAIVRGLEAVQTELDRGRFRFLPEDEDIHMAIERRLTEMIGPVGGKLHTGRSRNDQVALDIRLYLRSHLGHLQEALQEFQRVLVAKAKANRTVVMPGYTHLQRAQPILFAHHLLAYVDMIARDRSRLEDAYARLNVMPLGSGALAGTNYPIDRRYTAGLLGFPAVTTNSLDAVSDRDFMIEVAAALSIVMMHLSRLSEELIVWSSQEFRFVDLPDGFCTGSSMMPQKKNPDVPELIRGKTGRVYGQLMNLLTTLKALPLSYNRDLQEDKPALFDALETVMSSVRVMAELMRRLKMNREVLEEAVRKGHLLATELADYLVARGVPFREAHAVTGRIVRSAVDSKRELSDFSLEEFRTFSDRIEKGVFTRLSVPAAIDRKAQVGGTARVRVEQRIRELERSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I456</accession>
    <name>A0A1W1I456_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47790">
        <property type="protein sequence ID" value="SLM47790"/>
        <property type="gene ID" value="NSJP_1618"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1618"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012484086" evidence="1">
        <location>
            <begin position="27"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="37"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="235" mass="25618" checksum="B483E84A68506555" modified="2017-06-07" version="1">MLTLAACVRAVLVPTLVLLAVGPAFAQVITSGPASCPGVALTFDLCPVRGGSGYDQRLVDYLIEHRIAATFFMSGTWMAKHDDRVKELLTVPFFEVGTHGQVHAHLPAHSSESQKQEILGPVALLRTKYNRQAPLFRPPYGEYNTETVDLVKALGLRFVLWSVVSGDPDPALSAAQIETRLSRLTKQGSIIVMHANGKGAHTYDVVTRLHEHLLPQRHLTPMTVSEVLSCQPPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4A3</accession>
    <name>A0A1W1I4A3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Copper-transporting P-type ATPase</fullName>
            <ecNumber evidence="8">3.6.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">actP</name>
        <name evidence="8" type="ORF">NSJP_1660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.4" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1660"/>
    <dbReference type="EnsemblBacteria" id="SLM47832">
        <property type="protein sequence ID" value="SLM47832"/>
        <property type="gene ID" value="NSJP_1660"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1660"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
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    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045800">
        <property type="entry name" value="HMBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19335">
        <property type="entry name" value="HMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="827"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="852"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="TRASH" evidence="7">
        <location>
            <begin position="38"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="TRASH" evidence="7">
        <location>
            <begin position="113"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="881" mass="92673" checksum="CED1763508E4B38D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4H2</accession>
    <name>A0A1W1I4H2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="7">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">mraY</name>
        <name evidence="8" type="ORF">NSJP_1730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1730"/>
    <dbReference type="EnsemblBacteria" id="SLM47902">
        <property type="protein sequence ID" value="SLM47902"/>
        <property type="gene ID" value="NSJP_1730"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1730"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="358" mass="39494" checksum="A81C179E53A6054A" modified="2017-06-07" version="1">MLYIWLYPFHTEYSFLNVFRYLSFRIIYAAVTAFLIAFVLAPWLIRKLQEIKLGQQIRDDGPKRHLAKSGTPTMGGLLIIFAVLLSTLLWADITRPYVWLVMIATLGFGAIGFADDYLKFIKARSRGLTAGQKFSAQVGIALLIAVALYFTPGYTTKLSVPFFKNIMPDLGWFYIVFVVLVIVGSSNAVNLTDGLDGLAIGPVMIASLAYTIVAYVAGHRIMSDYLLIPHIDGAGEIAIFTAAILGSSLGFLWFNAYPATVFMGDVGSLPLGAALGTVAVISKHELLLLMVGGVFVIEAISVIFQVLSFKSRGKRIFLMAPIHHHFEMKGWEEPKVVVRLWIIAILLALLSLSTLKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4M6</accession>
    <name>A0A1W1I4M6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1778"/>
    <dbReference type="EnsemblBacteria" id="SLM47950">
        <property type="protein sequence ID" value="SLM47950"/>
        <property type="gene ID" value="NSJP_1778"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1778"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="353" mass="37800" checksum="2B81FD914E560B7D" modified="2017-06-07" version="1">MIHYHGYHANPFVITISPPFSHIIGRRHLGTLLGVWLIGIVAVHQAAAQVTVVDLQSPYSFVSGPAGNEYFISSVNGEPEQADNNGFITKLDASGKLTSLKFIQGGKNGVTLHAPKGMALAGSTLYVADLDAVRGFDTATGHSTGTVTIPSGMGGGSSAASLTDVAFDGKRLLYCSDQRANRIYRVEIDSGKVSLLIADPHLAGPTGLALHPKSGQLIAVSWDKGKIFEISPDGHLTELVSNGFFSSRFANLRGVDFDRWANMYVSDFTTGKVWRMTWDKRFQVIAEYLPSPGDLGIDRTNNLILVPYESAHAAEMNGLETPSEGKSKQEKRTLADYGFVPPPPKPGAGGATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4N5</accession>
    <name>A0A1W1I4N5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47978">
        <property type="protein sequence ID" value="SLM47978"/>
        <property type="gene ID" value="NSJP_1806"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1806"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="197" mass="21848" checksum="B8238AAED76EA926" modified="2017-06-07" version="1">MYWTTGILALLILTLSGCMMVREGKVKPPAQWPPQQAQPQKKSIGLIVTGALDPKGLTQMPRMETVESVRRQAFKAYSESGLFSEVVTSGEPTDVRADVSVIEEEGSGPGVWAYLSALTFAMIPGYVSEQLIVSTSFSDRQKRSLDSVEQNEELGFWMQFFLLFAMPFTESTASVSQSVHYDMHRATIQEAHSKGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4T8</accession>
    <name>A0A1W1I4T8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_1856</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48028">
        <property type="protein sequence ID" value="SLM48028"/>
        <property type="gene ID" value="NSJP_1856"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1856"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="134"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="239" mass="26078" checksum="E9B8E1637D40AFD3" modified="2017-06-07" version="1">MGGALVKPIILLVAVYLVLKFIVPNIPGSAPLPASLIFLYLMLVSSGIVIFATLSGESKDAFWGPIQRFMTGENIGGLQALRYGVLILFPLLVGWQTYGSTAQSDQPPAENRTIHPAPPGEYTGLSNPVAKTPENIMQGKGFYAAFCSPCHGGQFDGKGPAARGFNPPPANFSDPTTIAMLQESYLFWRIKKGGVGLPIEGMPWKSAMPRWEVELPDEWIWKIIMGEYDGAHQSPRTWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I511</accession>
    <name>A0A1W1I511_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1910"/>
    <dbReference type="EnsemblBacteria" id="SLM48082">
        <property type="protein sequence ID" value="SLM48082"/>
        <property type="gene ID" value="NSJP_1910"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1910"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025269">
        <property type="entry name" value="SAM-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13102">
        <property type="entry name" value="Phage_int_SAM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="58"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="159"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="360" mass="41688" checksum="52E4C94056585C25" modified="2017-06-07" version="1">MGLVKRGNVWWMSFTYEGRQIRRSTETSDKRLAEAILGKVKVEIVEGKYFDKPREEAKTFLQLMERYLREHASRRMHYRRYVNMVDNLKAFFGNPKLHHVTPKTIVAFKNKRYVDGVMPATINRELAVLKKAFNLACREWEWTRDNPVCRVSMEREQNTRDRWLTEAEEGRLLKTALPWLRELILFAAHTGMRRGEILALNWNGVDFVRRTVTVFRSKNGERRTIPINQTVQDILTKRYETRGDASQTGESLVFGSEAQTCLDGSNLRRAFIAALKAAKIENLHFHDLRHTFATRLVQAGVDLYKVQRLLGHKSPSMTQRYAHHFPESLRDGVEILDRQRLISTISAQPAGGAMVDCVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5E4</accession>
    <name>A0A1W1I5E4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48237">
        <property type="protein sequence ID" value="SLM48237"/>
        <property type="gene ID" value="NSJP_2065"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2065"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="78" mass="8964" checksum="4558CAEB333AC6C6" modified="2017-06-07" version="1">MIQLHCIIEGCQGKVYAPAGTQNVCKEHFLHYLTWRRRKGPQMFLTYAGMTMEQRDAIVAEWRQTVRAVEPPAASQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5E6</accession>
    <name>A0A1W1I5E6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1881"/>
    <dbReference type="EnsemblBacteria" id="SLM48053">
        <property type="protein sequence ID" value="SLM48053"/>
        <property type="gene ID" value="NSJP_1881"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1881"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="186" mass="21203" checksum="A67D0F35E168674C" modified="2017-06-07" version="1">MATISPLTIQTKYDEPCIVRNPSKADAQAWIDHATMVMQESDFTKTDPEDVTTSHPELEEWITEMNIATATLALVAEVKGRLVGTLYCRAYKASRMSHVCVFAMSVRKEWWRQGVGTALVRTLNGWATQHPLIRKVTMRVLVHNERALALYKKLGFFVEGRFAQAVKAENGKFVDDYEMSLFVKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5G9</accession>
    <name>A0A1W1I5G9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mdmC</name>
        <name evidence="4" type="ORF">NSJP_2053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48225">
        <property type="protein sequence ID" value="SLM48225"/>
        <property type="gene ID" value="NSJP_2053"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2053"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="213" mass="23349" checksum="1B75AE10A321705A" modified="2017-06-07" version="1">MNQLVAAEIETYSEAHSIPESAVCRALREETQRTMEHPQMLVGPLEGAFLKMMIRLVGATRVLEIGMFTGYSALCLAEALPPDGTVLTCEIDEGPAKLARRYFSRSPDGGKISVRMGPAIDTMRDLTGPFDLIFIDADKTNYVRYYQRAFELIAPGGVILVDNVLWNGDVLTQPAPDEKTAAIQELNRIVAADPSVSGVLLPIRDGVFVIRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5K1</accession>
    <name>A0A1W1I5K1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydroorotate dehydrogenase</fullName>
            <shortName evidence="11">DHOD</shortName>
            <shortName evidence="11">DHODase</shortName>
            <shortName evidence="11">DHOdehase</shortName>
            <ecNumber evidence="11">1.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pyrDA</name>
        <name evidence="11" type="synonym">pyrD</name>
        <name evidence="13" type="ORF">NSJP_2098</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of dihydroorotate to orotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(S)-dihydroorotate + A = AH2 + orotate</text>
            <dbReference type="Rhea" id="RHEA:18073"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-dihydroorotate + fumarate = orotate + succinate</text>
            <dbReference type="Rhea" id="RHEA:30059"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="EC" id="1.3.98.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="11">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="11"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2098"/>
    <dbReference type="EnsemblBacteria" id="SLM48270">
        <property type="protein sequence ID" value="SLM48270"/>
        <property type="gene ID" value="NSJP_2098"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2098"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990663">
        <property type="term" value="F:dihydroorotate dehydrogenase (fumarate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04741">
        <property type="entry name" value="DHOD_1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.26.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00224">
        <property type="entry name" value="DHO_dh_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033886">
        <property type="entry name" value="DHOD_1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023359">
        <property type="entry name" value="Dihydro_DH_chainA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024920">
        <property type="entry name" value="Dihydroorotate_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0288">FMN</keyword>
    <keyword evidence="10 11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="12">
        <location>
            <begin position="4"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="68"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="246"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM48270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="308" mass="32686" checksum="E36C75839287DEBC" modified="2017-06-07" version="1">MDVSTTIAGVKFTGCFMNASGALCVTREELLALGRSRAGAIVTKSMTVEPRQGNPSPRYYGFSGGSINSMGLPNLGYRAYAELIPELKRFGKPIIASVAGLVEDDFPVIAEAVNAAGPDLIEVNLSCPNIPGKPQIGYDAEASERLMKRVRKIITVPMGVKLPPYFDPAHHALMGNVIGRCGVDFLNLINSVGNGLVVDPKTETVVIKPKGGFGGLGGTIIKPVALANVRAFWKHFDGRMPIIGTGGVMSGLDAFEHVLCGASAVQVGTLLVEEGVDVFGRLEAEFVACLREKGYHSIADCRGRLKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5R0</accession>
    <name>A0A1W1I5R0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate:ferredoxin oxidoreductase epsilon subunit</fullName>
            <ecNumber evidence="2">1.2.7.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">porE</name>
        <name evidence="2" type="ORF">NSJP_1991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.1" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1991"/>
    <dbReference type="EnsemblBacteria" id="SLM48163">
        <property type="protein sequence ID" value="SLM48163"/>
        <property type="gene ID" value="NSJP_1991"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1991"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="92" mass="9836" checksum="F576C5BD5BB9E7F7" modified="2017-06-07" version="1">MYNIAQVIDEKCTAKKGCRLCIMYCPEANCLDLNSAKMVAEVNIDRCKGCELCVVVCNAAKHEAIVMQAVSATGQLMSKKGESAGLGQAYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Z0</accession>
    <name>A0A1W1I5Z0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupredoxin_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2266"/>
    <dbReference type="EnsemblBacteria" id="SLM48438">
        <property type="protein sequence ID" value="SLM48438"/>
        <property type="gene ID" value="NSJP_2266"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2266"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012438731" description="Cupredoxin_1 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="2">
        <location>
            <begin position="24"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="144" mass="15352" checksum="7225FD7D0416C8AC" modified="2017-06-07" version="1">MVPSPMRYVILAAFSAAMSAWAPVLAADSPPLAAPVIVPVGADGVQRVTITLDSYSYAPAHLIVEAGKPVEFTLNSVTTLTPHNFIIKEPAAGLVVEQDVSAGKTAVVRFTPSKPGIFPIYCDKRLWPLPSHRDKGMEGTLEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Z5</accession>
    <name>A0A1W1I5Z5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48432">
        <property type="protein sequence ID" value="SLM48432"/>
        <property type="gene ID" value="NSJP_2260"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2260"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="136" mass="15037" checksum="8BA473CE8FBDA04B" modified="2017-06-07" version="1">MELRSIHGFTTSRRHLRLSPIVFIVSGGSLRVNPSADDRLTGYPKWRALGPYGKVCETLINETFLCAVPKTLPRLQAQRQPLGLQNMIACAAGGMACSTEPLRPSRRAVGNTSYPRLPCSCTPGRFSLESCRRFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I646</accession>
    <name>A0A1W1I646_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2298"/>
    <dbReference type="EnsemblBacteria" id="SLM48470">
        <property type="protein sequence ID" value="SLM48470"/>
        <property type="gene ID" value="NSJP_2298"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2298"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="297" mass="33549" checksum="0358837FA079EB69" modified="2017-06-07" version="1">MNSLSDLVRFGTSSWAYEGWQGLVYHRAYPKGRFSQDTLAEYAAHTFHDGESPLFRTVGIDHSFYHPADANQLAHYAGQVPDGFHFCQKVWEDITVPAYANLPRYGARAGKSNPHFLDVSLFHESVLTPSITGLGGKLGPFIFEFQRWGIEAPAFLNQLDQFLERLPSGQRYAVEIRNPALLGRRYADILRARNVAHVYNHWTSMPPLASQHQVLDRRFSASFAVLRLLTPLGLAYEKAVARYKPYNRVVQEQPRMRQDTVLIIKQAVHEGIPIYVLANNRAEGCSPLTVQALKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I659</accession>
    <name>A0A1W1I659_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48359">
        <property type="protein sequence ID" value="SLM48359"/>
        <property type="gene ID" value="NSJP_2187"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2187"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="58" mass="7144" checksum="C64C4AB64CDBF001" modified="2017-06-07" version="1">MAVLIRRYKGHNGMMQEERIDDDDRIERYFRLFEKDDVKKLETGVKVFIEKDEWQLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I666</accession>
    <name>A0A1W1I666_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2318"/>
    <dbReference type="EnsemblBacteria" id="SLM48490">
        <property type="protein sequence ID" value="SLM48490"/>
        <property type="gene ID" value="NSJP_2318"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2318"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012912929" evidence="1">
        <location>
            <begin position="28"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="457" mass="48569" checksum="A5076440C121F528" modified="2017-06-07" version="1">MVTRLSLLAISFTALLLAAILASGATATTPGTSLEQEASQAYREAEYDKVLKLWNSRPSDSTPSKDLLRVTLQSYLKLGQTGEALTLYDRLVPSDQPDEFPLLRSLALSTLTTHVRDPKEYVRIAAYSALAELGLAETRSILEDGLLDPSPLVRARAVEGLGRAGLASKSDALRRALRDDMPPVRIAAMNVLSEGGVNDIVPRLIEVARTEDGPEGVFAYAALYRLGKQDMLRDITGAATLPDPETRMAALGALGKLKRPSTLAVLSQGVYDPEPSVRAFAAGALGEFGQPGAVAPLTHAIGDEHARVRGTAAVSIGRLGIPETRPLLLQLTRDASMQVRANAVEGLLRLGDSSAVLIATDLARHPDPSVRAATAQALGMASDKQGITILQTLLQDQQPQPRLFSAKALGKTNPPPFALLKKGLHDSDSAVRITVAGSLLQQIDRHSKSTASKGRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I668</accession>
    <name>A0A1W1I668_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mazG</name>
        <name evidence="2" type="ORF">NSJP_2197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2197"/>
    <dbReference type="EnsemblBacteria" id="SLM48369">
        <property type="protein sequence ID" value="SLM48369"/>
        <property type="gene ID" value="NSJP_2197"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2197"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00444">
        <property type="entry name" value="mazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="172"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="284" mass="32119" checksum="B4F895A79E7359CF" modified="2017-06-07" version="1">MSTRFDKLAQLMAALRAPNGCPWDRKQTHESLKPYLLEESYEVLDAIDHQDRAKLSEELGDVLLQVLFHGQIASENGAFTLDDVLDRLADKLIRRHPHVFAPGTNETTPLNSDQVLTRWEDIKKAERRAAGRPDSVLDGIPAALPALLRAYQIQARASRVGFDWSHDQGGFEQVLAKVEEEIRELQEAFRLPETDEASSTRQRDIVAELGDVLFSLVNLSRFMKVNPEDALRLSVNRFVERFRFIEREASRTGRSVGELSFDEMNNLWEAAKRGGSAHAQDDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I696</accession>
    <name>A0A1W1I696_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">rplR</name>
        <name evidence="8" type="ORF">NSJP_2354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2354"/>
    <dbReference type="EnsemblBacteria" id="SLM48526">
        <property type="protein sequence ID" value="SLM48526"/>
        <property type="gene ID" value="NSJP_2354"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2354"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="121" mass="13424" checksum="A3FA895AAC174FF6" modified="2017-06-07" version="1">MNSLEKNRQLARRQQRVRQRIFGTDARPRLNVFRSSSHIYAQIIDDLKGLTLASASSLDKSLRTTLKSTSSIEAAKAVGKLLAERAKAAKVQTVVFDRGGRLYHGRIKALAEASREGGLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6B7</accession>
    <name>A0A1W1I6B7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48552">
        <property type="protein sequence ID" value="SLM48552"/>
        <property type="gene ID" value="NSJP_2380"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2380"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012912931" evidence="2">
        <location>
            <begin position="21"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="306" mass="33135" checksum="0F5D4D21B03E0124" modified="2017-06-07" version="1">MGLPSSFLRNAAVVSILSLAACATSSELDLMLQESDRGTVVLERITDRSFQAAHPIKLPAGTVARVLRGVLVRDDQGFLQDIGVRKADALQAFSEEDVAYLAPLITDGLSRAASDQQVGFTVNQQGPPVYSQRVGAAVGSSEPPLRLAPPETTAGSIYAYGRSLYVTLTQYRYRVERPDTINMPNRRVPDRTGLLNHTVMFIPESAKRDDKYRTALSTDTTLVIDYELLAGLPLDAGREIVRQPPPAAPAPASAQGAPAKVGDTNKKDPELEALRKELEDIKRQLADQDTRRQPAPPKPSGTPKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6C6</accession>
    <name>A0A1W1I6C6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Urease accessory protein UreD 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureD</name>
        <name evidence="3" type="ORF">NSJP_2390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2390"/>
    <dbReference type="EnsemblBacteria" id="SLM48562">
        <property type="protein sequence ID" value="SLM48562"/>
        <property type="gene ID" value="NSJP_2390"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2390"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="PTHR33643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="304" mass="34025" checksum="8DBB887F61C27CD3" modified="2017-06-07" version="1">MTAFRHLPELTSFQDEPSQMPSGAVGKNAFLRLGFERRGDRTVLAHLDRRAPLLVQQALYWDEALPDLPCVFMITTTGSILQGDRFNIEIDLAPDARAHITTQAATKIHSMDANYAAQTQRIVLGENAYLEYLPDPIIPHAQARFAAFTRMDVHPTATALYSEILMGGRKHHNEGELFQYDVLSSTVRGQRPDGTELFTEKFVIEPRVHDVRQVGVMGAYDVFANVLLLTPRHHADAVFSQVPAIVNREEQWAAGASRLPNDAGLVFKVLGQESEPVQARVREFWSIVRRTVTGASVQPKSAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6D0</accession>
    <name>A0A1W1I6D0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease subunit alpha</fullName>
            <ecNumber evidence="5">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urea amidohydrolase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 13" type="primary">ureC</name>
        <name evidence="13" type="ORF">NSJP_2394</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 10">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7 10">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="5 7 10">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Carboxylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2394"/>
    <dbReference type="EnsemblBacteria" id="SLM48566">
        <property type="protein sequence ID" value="SLM48566"/>
        <property type="gene ID" value="NSJP_2394"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2394"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 7" id="KW-0533">Nickel</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="12">
        <location>
            <begin position="134"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5 8 9">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="5 7">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="5 6">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM48566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="572" mass="60749" checksum="F9F4F915C15F28CB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6E0</accession>
    <name>A0A1W1I6E0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48560">
        <property type="protein sequence ID" value="SLM48560"/>
        <property type="gene ID" value="NSJP_2388"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2388"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="167" mass="19460" checksum="6CA2CCE62B895738" modified="2017-06-07" version="1">MHEEDNLHQPVELRSDSSRQCRRKLSFPMIRRRRTFQVRTILAKSGPGHVVICAMTLVLTVTGCATKHYTPLAEADDDQVEQLTENVFRVEYRVSAFTSQAALDRYFLRRCAELTLRESYDYFHVGRRFDILMLSRRTSMTLTMFKGERPADNPDLIDARSVLRESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6H2</accession>
    <name>A0A1W1I6H2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytochrome_C554 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2412"/>
    <dbReference type="EnsemblBacteria" id="SLM48584">
        <property type="protein sequence ID" value="SLM48584"/>
        <property type="gene ID" value="NSJP_2412"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2412"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023155">
        <property type="entry name" value="Cyt_c-552/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13435">
        <property type="entry name" value="Cytochrome_C554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C554" evidence="2">
        <location>
            <begin position="63"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="474" mass="53083" checksum="F907B7618FC9447E" modified="2017-06-07" version="1">MDEPVTVSGEDSGASEHASDGRRNFTRYMIGGLCLVLFLALTGVGYVQVEERRGGGIRPFVSADNKKCIDCHTAKDVGVGVINDWKVSRHAPKGIGCVECHRAEHGDADAYDHEGFLISTLVTPKDCMRCHDREAKEFGKSHHAKAAQFTGSLDNFLGNVVEGPEVVTTGCAGCHGSVVKVLDKGKLHPATWPNSGIGRVNPDGSKGTCSACHARHSFSVAQARQPESCGRCHMGPDHPQIEAYYESKHGVLYEANKEKMKLAEPAEKWRPGKNYLYPTCATCHMGATGSQEVTHDVGDRISWTLRPVVSTRLENFEDRRKAMRQVCASCHSEQIVERFFISMDQGINLYNDKFGKPAKEAMDKLTAMKKITPTPYDEKIEWVFYELWHHEGRRARHGLSKMAPDYVHWQGFYEVAKSFYTKFLPLVRDLSPQVAEELLRNEGHRWIERGMSKEDISQMLEFYDKEMQGKRGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I773</accession>
    <name>A0A1W1I773_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_2491</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FUN14 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48663">
        <property type="protein sequence ID" value="SLM48663"/>
        <property type="gene ID" value="NSJP_2491"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2491"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="151" mass="15736" checksum="BFAFA0368FC30681" modified="2017-06-07" version="1">MKEPLDDDAEGASPAPRGFFETLVADGPWTAKSFVAVSVATVAALVAWVTSFSSPDAARFGGSYLGGYFIGWAFRRFLRFAALVAGGILAAVTLLKNTGWIDLDWGSVETQVGQAAASIHQGAQGLRQTLSGYLPSAGAGAAGVFFGFRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7A2</accession>
    <name>A0A1W1I7A2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48880">
        <property type="protein sequence ID" value="SLM48880"/>
        <property type="gene ID" value="NSJP_2713"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2713"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="13"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="108"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="165" mass="19277" checksum="65A0A04404FF3FC6" modified="2017-06-07" version="1">MSHTELSEVFFEHEEGLFRFLLKRLKCTFTARDLTQELFLKISAQEDTQHIHNQKAYLFRMAANLATDHLRVEQNRAEILAEANDILWGGTEHRHAERVMIARQELARLEQALNELPSLSQNIFQLNRFGHKTQQEIAKEFGISISTVEAHMRKVLDHLSSVRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7B0</accession>
    <name>A0A1W1I7B0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphate transporter subunit ATP-binding component of ABC superfamily</fullName>
            <ecNumber evidence="6">3.6.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pstB</name>
        <name evidence="6" type="ORF">NSJP_2717</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.27" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2717"/>
    <dbReference type="EnsemblBacteria" id="SLM48884">
        <property type="protein sequence ID" value="SLM48884"/>
        <property type="gene ID" value="NSJP_2717"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2717"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015850">
        <property type="entry name" value="ABC_transpr_PstB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423:SF3">
        <property type="entry name" value="PTHR43423:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="13"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="261" mass="29181" checksum="9EA4E0DBA9232AB8" modified="2017-06-07" version="1">MSLSTPPNGALKAESKGLSFFYGNVQALNAISLGLPDRHATALIGPSGCGKTTYLRCLNRMHDLYPGNRYEGELLLYPDGINLVAAEIDPIEIRMRIGMVFQRPNPFPKSIYENVAYGLRIRGGMKRTDLDHAVERALRDAALWPEVQDRLHDQALNLSGGQQQRLCIARALATRPEILLFDEPTSALDPTATARIEELVTDLKQKVTIVIVTHNMQQAARVSDYTAFMYEGRLIECDRTDRIFTNPSNKLTEEYVTGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7C1</accession>
    <name>A0A1W1I7C1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type II secretion system core protein G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">gspG</name>
        <name evidence="13" type="ORF">NSJP_2733</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GSP G family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2733"/>
    <dbReference type="EnsemblBacteria" id="SLM48900">
        <property type="protein sequence ID" value="SLM48900"/>
        <property type="gene ID" value="NSJP_2733"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2733"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013545">
        <property type="entry name" value="T2SS_protein-GspG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010054">
        <property type="entry name" value="Type2_sec_GspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08334">
        <property type="entry name" value="T2SSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01710">
        <property type="entry name" value="typeII_sec_gspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSG" evidence="12">
        <location>
            <begin position="61"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM48900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="184" mass="20086" checksum="E64F967C75310D95" modified="2017-06-07" version="1">MSDRMEPNDGQTARQTALDFRTASRGSLPHPLLLGQRGFTFIEIMVVVAILAILAALVVPRIMGRTDDAKRTAAKVQIRNLEGALQLYKLDNGVYPTTEQGLKALVEKPSVGVVPKKWKLGGYIPNLPEDPWGNPYKYVSPAPVQQGQYGQIKGDYEITSFGTDGESGGEGVNADITNWNLDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7I3</accession>
    <name>A0A1W1I7I3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NADPH-dependent oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2787"/>
    <dbReference type="EnsemblBacteria" id="SLM48954">
        <property type="protein sequence ID" value="SLM48954"/>
        <property type="gene ID" value="NSJP_2787"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2787"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="70"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="351" mass="39118" checksum="5D9D1158BE789B70" modified="2017-06-07" version="1">MKFRSHSSKGLSAGLNRRQMLKVLGAAGSALALNGTSGMETLFASNSPTTATGDLPRRALGKTGLEVSAICFGGAHWGRLKDDTEAIRLMHEAIDAGINFCDNAWEYNNGRSEELMGRALVERRQRVILMTKVCSHGRGKKVAMQQLEESLRRLKTDYLDLWQIHEVIHEDDPDRHFMAGGEVEALVEAKRQGKVRFVGFTGHKEPRILLKMLSHDFPFDTCQIPLNVFDGTYRSFEREVLPVLNERGIAPLGMKSLTGNGEPIKQGIVNPEEAIRYVLSLPIASLVSGIDSPAVLKQNLDIVRRFTPMTAAEMNGLRVKVSRYAMDGRFEKFKRSIHHDGWVGREQHGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7J4</accession>
    <name>A0A1W1I7J4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore coat protein CotH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2797"/>
    <dbReference type="EnsemblBacteria" id="SLM48964">
        <property type="protein sequence ID" value="SLM48964"/>
        <property type="gene ID" value="NSJP_2797"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2797"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="457" mass="51030" checksum="F12331A895AC2670" modified="2017-06-07" version="1">MTPPHCRGSIRLLGMSLNYARFISPYIHIVFILAVLAGCSGGGDNQSGGTGNSGTQGQSTPAPASALPVLSVATDNGAEISSKEDYASAKYTMKSDAGQIINDSTLDIRGRGNSTWEMPKKPYRVRLTDSAPLMGMPANRHWVLLANYSDKTLIRNDVAFEMSRRLGLAYTPRSTFVELWVNGTDRGIYQLTEHIRIADERVNIPQLDEGDTAPDKITGGYLIEIDARRGEDFCYESPKTGVVFCLSDPEDLLEPGWENQRAYIEAYINQTEDALFSDHFTDPATGYAAYIDVDSAVNYYLVNEWVKNVDSPQFSSVYLYKKRDGKLTFGPVWDFDLAIGNVDYTNNFGDPGDPAGWYVRKAPWFARLFQDPAFEAKVKARWAQLEASGAVEGIFTYIDNRASRLSGVQTNNFQIWDILNTKVWPNRVVTGSYEGEVNAMKTWLRTRTNWIDSQLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7K0</accession>
    <name>A0A1W1I7K0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48783">
        <property type="protein sequence ID" value="SLM48783"/>
        <property type="gene ID" value="NSJP_2616"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2616"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="20"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="132" mass="14912" checksum="F86D7679F8013794" modified="2017-06-07" version="1">MNDQTREQEEPRLSDVNRFRRHPRVRIAAPFACALSSLKPRHWLRKPTVNLGVVYDLSLRGARVSTRAVMRPGDEVTITLRLPKQIRSADVSSATVRWTRDQFVGLAFTRLSAASYGRLKKYVAIATGAVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7K6</accession>
    <name>A0A1W1I7K6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49028">
        <property type="protein sequence ID" value="SLM49028"/>
        <property type="gene ID" value="NSJP_2861"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2861"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012280527" description="Ysc84 domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Ysc84" evidence="2">
        <location>
            <begin position="117"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="238" mass="24999" checksum="21A7B974A63358C7" modified="2017-06-07" version="1">MITDLRRLGMRFRAAAVGMAVCAVLGGYAASPALSADAPDQQQVVDKAKMTLDSFGEDEGMKAALKELGKESKALFIIPQFMRGAFIFGGAGGSGVLIVRDEKSGKWSDPVFYNIGSASFGLQIGADVSEMVLVVRTQKGLEEFYTNDFKLGANAGMAVGPVGAGIAAKGISADIVSYAKKKGAFAGIALDGSGVTVSNDSNKAYYGREVRPTDVIVKKEVGNPKSLKLRESAEKLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I848</accession>
    <name>A0A1W1I848_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2998"/>
    <dbReference type="EnsemblBacteria" id="SLM49165">
        <property type="protein sequence ID" value="SLM49165"/>
        <property type="gene ID" value="NSJP_2998"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2998"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="588" mass="65750" checksum="C19778D68A53AC6A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I890</accession>
    <name>A0A1W1I890_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_2856</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2856"/>
    <dbReference type="EnsemblBacteria" id="SLM49023">
        <property type="protein sequence ID" value="SLM49023"/>
        <property type="gene ID" value="NSJP_2856"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2856"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031640">
        <property type="entry name" value="Glu_dehyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16912">
        <property type="entry name" value="Glu_dehyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="3">
        <location>
            <begin position="27"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Glu_dehyd_C" evidence="4">
        <location>
            <begin position="146"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="349" mass="37405" checksum="75AEEA192CF975B0" modified="2017-06-07" version="1">MKAVTVEPSKPDSARLQDVPEPDAGTGSVLVEAIAVGICGTDQEIVQGHYGWAPSGERHLILGHESLGRVLDPGPIGSLKEGDLVVGIVRRPDPVPCPNCAAGEWDMCRNGRYTERGIKEMHGFMSERWRIEPDFAMKIDQSLGLLGVLLEPTTVVTKAWEQVMAVGSRAFWEPWCVLVTGAGPIGLLAALLGKQHGFEVHVLDRATSGPKPDLVQSLGAGYHTGSVLELDFEPDIIIECTGDGRIVSDSIRAVKAGGVLGLTGVGGGEQMDGSFGADLATEAVLGNKVIVGCVNANKRHWYKASRALARADRSWLARLVTRREAPENFSRALEKESTDVKVVVQFADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8B9</accession>
    <name>A0A1W1I8B9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49235">
        <property type="protein sequence ID" value="SLM49235"/>
        <property type="gene ID" value="NSJP_3068"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3068"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="90" mass="9683" checksum="690D8A59E6BA415F" modified="2017-06-07" version="1">MATPRAAPHRFHFSQKAQAGTCSCGRWAITRRRAMTNKAGPGPAFVELTEQQALKDWGNHIANLPEGQTVHSSASVRTHRAAIKHGGIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8F6</accession>
    <name>A0A1W1I8F6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49201">
        <property type="protein sequence ID" value="SLM49201"/>
        <property type="gene ID" value="NSJP_3034"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3034"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="492" mass="53709" checksum="817DEF6CC25A6A24" modified="2017-06-07" version="1">MKQTVLTPECSRWQKLNLRLILYVIGSVLLVGVPAPASVKAFGDLLFCHGCTYDTVRLSCPGPVMKKPATFSSNPPGFASYPFEEQCPVSLQAGQYHNGVIHLFFEGRWNPSETRQDRPNAVETLFVENYEQFFPNRQMKGPGERRIFVYWTARCTADPWLQGGTCQRLGEYVPADVKAAFPSEIDDKPFPLTKDSLSAKLKQQLIKQYQAANPQGSPRMSNQQRIQSMMTEPQQAPMVKPSQSSQVMMAQPPQSQVMTQSQTANVMEAQPQSALPKTQASTGALARSGLFSRGVDEKDGQILNQEGNEAPAEAAAETSDPAVIEERTPEMVEPVALKLDRSFHATDAKGEAVELKTGAYEVGPIMDLQLGLAKEGQSTVLLNAKQDRHSFPIHRTLALVIPGPSDDMHLLYLTADGRRFDAIGFPSAVKPRSVDHIAPLPDKTIEAAVLAASVSPRGVSSPPCQPNPASTGPHWIPVPCTVHTQPHQPSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Q1</accession>
    <name>A0A1W1I8Q1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49384">
        <property type="protein sequence ID" value="SLM49384"/>
        <property type="gene ID" value="NSJP_3217"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3217"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="147" mass="15575" checksum="3FF269B1A4D49F4F" modified="2017-06-07" version="1">MGLITTLGYMMLLCFGAMIAPGVGMSGRLITQMPPVLLEWAHAPGYGILAWLLTRSLRGRGWPIVYAVLAASSAAFVFGLWTEVLQGLVPGRSTSSDDLAVNAGGITLIACAMLAQNRTEGRAARPVMLSVKRIGSSSILSLRRLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Q7</accession>
    <name>A0A1W1I8Q7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3235"/>
    <dbReference type="EnsemblBacteria" id="SLM49402">
        <property type="protein sequence ID" value="SLM49402"/>
        <property type="gene ID" value="NSJP_3235"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3235"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021747">
        <property type="entry name" value="DUF3313"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11769">
        <property type="entry name" value="DUF3313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="242" mass="26638" checksum="91FFF8B7C704EE51" modified="2017-06-07" version="1">MVPLSRILLIGLIVTLCGCPATKQARTVDKLGFLKDLYPIMTKGNEDAGESLLIYKNPKVATIPPNSYTKILLDPVLIFRGPESKMGGISQSETQMLADTFYALIYQELSKDYDMVDKPGASTLRVQVAVTHLEESWPMLDVVSNVPAPMNALAAGSVIKTIATGKPAFTGEAVIEAKVTDAQTGEVLRAMVDRRVGTKKLEAQSFNSWADVYESLRYWAENGRYHLCKARQIRTDCPKPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Y3</accession>
    <name>A0A1W1I8Y3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative sulfite oxidase cytochrome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3283</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3283"/>
    <dbReference type="EnsemblBacteria" id="SLM49450">
        <property type="protein sequence ID" value="SLM49450"/>
        <property type="gene ID" value="NSJP_3283"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3283"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="67"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="188" mass="20473" checksum="E4A087F6C68A2C56" modified="2017-06-07" version="1">MDTCGTSLSKSSMVALGSLTIALGCVWTGWSAEERDYGVGRPATQEQIRAWDIDVNSVGEGLPPGQGTVKQGAQVFASKCAMCHGPTGIEGPKDKLVGGHNTLMTAKPLKTIGSYWPYATTLYDYVHRAMPFTAPQSLTPDETYSVVAWLLFQNKIIPEDMVIDAKTLPAIRMPNRDGFVRDPRPDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Y5</accession>
    <name>A0A1W1I8Y5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49455">
        <property type="protein sequence ID" value="SLM49455"/>
        <property type="gene ID" value="NSJP_3288"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3288"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="59" mass="6419" checksum="16B9BA5F9CE9309B" modified="2017-06-07" version="1">MKNVDMTVEGTILTIKVDLSKEFGPSASGKTIIIASTEGNVTIPNREEKVGLNVYRKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I940</accession>
    <name>A0A1W1I940_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49537">
        <property type="protein sequence ID" value="SLM49537"/>
        <property type="gene ID" value="NSJP_3370"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3370"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007420">
        <property type="entry name" value="DUF465"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038444">
        <property type="entry name" value="DUF465_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04325">
        <property type="entry name" value="DUF465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="80" mass="9592" checksum="81CBF958E8DE6587" modified="2017-06-07" version="1">MLTDNVIMERLRQSNTEFRELEESHHRLDLELNDLQRRHVLTPAEELSKKQLQKEKLAKKDKMAEMIRVYRDHGLQATAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I979</accession>
    <name>A0A1W1I979_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable endolytic peptidoglycan transglycosylase RlpA</fullName>
            <ecNumber evidence="3">4.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rlpA</name>
        <name evidence="6" type="ORF">NSJP_3196</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the RlpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3196"/>
    <dbReference type="EnsemblBacteria" id="SLM49363">
        <property type="protein sequence ID" value="SLM49363"/>
        <property type="gene ID" value="NSJP_3196"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3196"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02071">
        <property type="entry name" value="RlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034718">
        <property type="entry name" value="RlpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012997">
        <property type="entry name" value="RplA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00413">
        <property type="entry name" value="rlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPOR" evidence="5">
        <location>
            <begin position="145"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="226" mass="24495" checksum="0FD697894D91FB36" modified="2017-06-07" version="1">MPDGLLRVRVSFLFTALVLAFIGLTAGCSAPAPKPTYFPGYPIGYTERGVASWYGPGFHGNKTANGERYDMHQLTAAHRTLPLGSIAVVRSLNSGRQVTVRINDRGPFAKGRILDLSLAGAQALEMVGNGTASIELRVTGFQGRSADMGALRIQIGAFSDQQNALNLLNRARQVYPIGRIQTIDLPEGRRYRVQVGEFRSEAQAESAAAKLQSDLAVQPFVFRDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I987</accession>
    <name>A0A1W1I987_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Sensor histidine kinase</fullName>
            <ecNumber evidence="5">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_3399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3399"/>
    <dbReference type="EnsemblBacteria" id="SLM49566">
        <property type="protein sequence ID" value="SLM49566"/>
        <property type="gene ID" value="NSJP_3399"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3399"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="103"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="240"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="465" mass="51036" checksum="1F84884DA6B3818A" modified="2017-06-07" version="1">MFRPVPVTVRFRGVPLWLMAAVFLSLALLLSFLLLLSLQQDQRLLQDFSKDGSVPTKHFAALWQSRRDLVLVALLVFVAAAGAIGAVIAFLHYDSARRTLEAVKGLARNILESIPTGILTLNQSGIITAVNPAAEVVLTRSSGDLLGCAYESVFAPGDVIRHVLDTALRMQEHVRQQDLPYQGRDRESRTIRVTTAELTGDDGLSAGIILQAQDVTDWLALEQRLRVAEKLSALHTLSAGVAHELRNPLSAVDLNLHLLEDELARQAGLREDADHYIRILNAECRRMSAILDTFMKFAGPGSHGLHEVDVPSVIDYIMSLMRFEADERSIRLEHLVEDGLPPVLGDETQISQVLVNVMANSFHAMQSGGRCRVEARCRRGNGQEWVDITVSDTGSGIKNEDIAHLFEPFYTTKSEGSGLGLAIAYRIMHDHGGTIHVSSEYGQGTIVLLQFPAETGQLRSVTVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9D1</accession>
    <name>A0A1W1I9D1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49489">
        <property type="protein sequence ID" value="SLM49489"/>
        <property type="gene ID" value="NSJP_3322"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3322"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012732208" evidence="2">
        <location>
            <begin position="20"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="157" mass="17068" checksum="14AE8381563330C5" modified="2017-06-07" version="1">MKRVSFLLFFLCFGLPAWAENSAWTGTWVLRELQPGGQLTMKIEETNAGWKMTYKVVGPGAPGASDTTIVTMLDGKDVPVLIDGKASKQTMGISKVDGHHTVNIIKFGGKEIGVSKAELSADGKLIRVETDYPESNPGAPAGKQIQFWDRKERTSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9J2</accession>
    <name>A0A1W1I9J2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49718">
        <property type="protein sequence ID" value="SLM49718"/>
        <property type="gene ID" value="NSJP_3551"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3551"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="137" mass="15814" checksum="8CF50991D601DBC0" modified="2017-06-07" version="1">MTLPQRHCGRRSMGRRRETSIRESGDPTDGGSSTLRAKGRFSCRRVPFRSGFERSCLHWAFSFPSMPLPPKKRQYLARGQVLFPPSHRYLTKPGNPLLRLLKVCQSIDQRFSKLRKSSSVPRRRKCPSSKSPARWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9J3</accession>
    <name>A0A1W1I9J3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-3-O-acylglucosamine N-acyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.191</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">lpxD</name>
        <name evidence="9" type="ORF">NSJP_3517</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:53836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="EC" id="2.3.1.191"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transferase hexapeptide repeat family. LpxD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.191" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3517"/>
    <dbReference type="EnsemblBacteria" id="SLM49684">
        <property type="protein sequence ID" value="SLM49684"/>
        <property type="gene ID" value="NSJP_3517"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3517"/>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03352">
        <property type="entry name" value="LbH_LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00523">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007691">
        <property type="entry name" value="LpxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020573">
        <property type="entry name" value="UDP_GlcNAc_AcTrfase_non-rep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43378">
        <property type="entry name" value="PTHR43378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04613">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01853">
        <property type="entry name" value="lipid_A_lpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 6" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LpxD" evidence="8">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="370" mass="39109" checksum="19FDF506AC6F1A20" modified="2017-06-07" version="1">MAVPIVSNPCSLSEIHQVIGGTLHGDGAVALSVLTSLNEATPHALSFVLNDKALKGTPEIRAGALLAHRHIPELPIPHIVVPNPMLALAQVAQRFFVRPYKARGVATEVIRGTDVRIGADPSIWPFVTLGDGVTLGARVTLYPGVFIGAGSSVGDDSLIYPNVVIREGCTIGNRVIVHSGTVIGSDGFGYVQHEGRHHKIPQLGGVTIEDDVELGANVSIDRATLGQTIIRKGTKVDNLVQIAHNVTIGEHAVLVAQVGIAGSTTIGRHVMIGGQAGLADHIQVGDQVMIAARAGVNRNLEPNQIVSGAPVMPHETWMKAQAVIPRLPELRQLVRSLEARVALLETQVAKAGTARTKGASPRKPVRRTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9K2</accession>
    <name>A0A1W1I9K2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Membrane-fusion protein of multidrug efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_3509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3509"/>
    <dbReference type="EnsemblBacteria" id="SLM49676">
        <property type="protein sequence ID" value="SLM49676"/>
        <property type="gene ID" value="NSJP_3509"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3509"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012393412" evidence="3">
        <location>
            <begin position="20"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="80"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="404" mass="43878" checksum="C76E235E1A3E2BB1" modified="2017-06-07" version="1">MRFVSLSLCVFSLFLVVTACGREEAAHNPKPASGNSYEPDAPNADENKPVDVQVTKPSKQLLVYSITLPANIAPLYQTTLYAKVSGYLKWIGPDKGDTVKKNQVVAVIDAPEVEEQYLQAMADYKIKKITFDRLMKVWNEAPDVIAKQDVDVAEAAYEGARNLMQQRAVLRDYTKVRAPYDGIITARFADPGALIQVATSSATTAIPLFTIMDLDTVRVYASVPQDESPWVVAGKTKASVTVTELPDRSFSGTVTRSTLALDPSTRSLLIEVDLPNGDHALKPGTYAEMTVDLREIPDALVLPPLAVTSGPSGHSVFIVEQGKATSVPIRTGITSGKFIEIVQGLNADDEVVVVGKRRLLEGSPVHASPYHLPEAVPARQRFERKSAGLPPAESATVDQDKRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9N7</accession>
    <name>A0A1W1I9N7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpsB</name>
        <name evidence="7" type="ORF">NSJP_3590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3590"/>
    <dbReference type="EnsemblBacteria" id="SLM49757">
        <property type="protein sequence ID" value="SLM49757"/>
        <property type="gene ID" value="NSJP_3590"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3590"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="257" mass="28665" checksum="1841E8979770CABF" modified="2017-06-07" version="1">MGVIAIKELLEAGVHFGHQTNRWNPKMKKFLFGERNGIYIIDLQQTVTRMDDAYAFVRDTVASGQTILFVGTKRQAAEILQEEAVRANMFYVNQRWLGGMLTNFQTIRRSIDKMKKIEGMLADPAQHGLTKKEISQKQKELVKLQKFLTGIKNMRGLPGAVFILDTRIERIAVQEATRLDIPVIAIVDSNCDPDHITYPIPGNDDAIRSIKLITSKIAEACIEGNHLRTQREEAEFQSSPAGDDKVGTATLAAAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9S3</accession>
    <name>A0A1W1I9S3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49742">
        <property type="protein sequence ID" value="SLM49742"/>
        <property type="gene ID" value="NSJP_3575"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3575"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="75"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="130" mass="14365" checksum="FE5E8B7FEEF05CBF" modified="2017-06-07" version="1">MVPVKSFMVPKDKFVTVERDTDVQTAGRIMRDRGIGSLFVTNGKEIIGIITDTDMVRRVVAAGADTHKTTVEQIMSAPIMTIEESKTLLDANDLMAQSHLRHLGVTKEGKLVGMISVRDLVVFLTNLPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9T9</accession>
    <name>A0A1W1I9T9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3617"/>
    <dbReference type="EnsemblBacteria" id="SLM49784">
        <property type="protein sequence ID" value="SLM49784"/>
        <property type="gene ID" value="NSJP_3617"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3617"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="129" mass="14786" checksum="4FF78A4DF8A4BAB6" modified="2017-06-07" version="1">MGRRYDHVDVRVRSLNKVREFYRTILPALGFTHKVDLDGWLQFEAADHVEAREFFGVTESASHVPNECRIAFWAESTNEVDRLADIVIRAGARNVEGPGYDEGLGYYAVFFEDPDGNHLEICHREEGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAD7</accession>
    <name>A0A1W1IAD7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49966">
        <property type="protein sequence ID" value="SLM49966"/>
        <property type="gene ID" value="NSJP_3799"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3799"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="307" mass="34519" checksum="67B918AA29AA632B" modified="2017-06-07" version="1">MPPESTARCRRTTVTLPEYGSILSRQGARIVTGSHGTFWVQVENHTLGRMPTFCLDSPDPGEVRRVIKQGRAGVASYLMKTSAEHPPNAWLYICEDPGYSLEKLAPSMRRNVRRALKELRVAPLTAEDVIQHGLPAFSDTRRRVGLADGTEDAFRKRFSVRAQCRAHVFVGAWKDNLLAAFLSITEVDDWAEIEGCFSRDALLEFRPNDILMYTVLSQYLVHEGRRLVSYGASSIQPGTSAEGLHAFKTKVGFSAQPVHRAFELHPLLRPFTNRLTFWTVNRLLALRPMNRSLRKTAGLLATLTDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAI7</accession>
    <name>A0A1W1IAI7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Multi-domain non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3901</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3901"/>
    <dbReference type="EnsemblBacteria" id="SLM50068">
        <property type="protein sequence ID" value="SLM50068"/>
        <property type="gene ID" value="NSJP_3901"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3901"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1002"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2075"/>
            <end position="2149"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1037"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM50068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="2637" mass="288621" checksum="7685C6276CB69A54" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAJ5</accession>
    <name>A0A1W1IAJ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50015">
        <property type="protein sequence ID" value="SLM50015"/>
        <property type="gene ID" value="NSJP_3848"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3848"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="47" mass="4803" checksum="8F7F7201E6E043AF" modified="2017-06-07" version="1">MQQELSSDVAKAIAGHIYGESELPAEATRPAGCPREGAGQKPAAATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAN5</accession>
    <name>A0A1W1IAN5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Iron dicitrate transmembrane sensor FecR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3950"/>
    <dbReference type="EnsemblBacteria" id="SLM50117">
        <property type="protein sequence ID" value="SLM50117"/>
        <property type="gene ID" value="NSJP_3950"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3950"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032623">
        <property type="entry name" value="FecR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16220">
        <property type="entry name" value="DUF4880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="DUF4880" evidence="2">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="1">
        <location>
            <begin position="126"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="332" mass="36658" checksum="43D8085292B174C8" modified="2017-06-07" version="1">MALSDSDSDIDPLGGDTTIDEQATAWFVRLRSGSLSEEDRRAFESWRRQSDAHALAFEEACRLWDDEALKLAAASAAGMTSVSSVLQPRTPAKGRPIWQWWMVAATCAVLMVVVYQLDIVVRLSADHRTSTGEQLEIQLPDHSLATLNTRSAIAVNFDGTSRTVRLLDGEAYFEVEPDRERPFMVEGQQILSRAVGTKFLVRRKLGDIRVTVVEGTVELAPAAGGWEPIQLTAGRQAIADTHAVGTVREVDLSTEMAWLRGRLVFENAKLSDVIDEIRRYHPGVILIWSPTIGDIRVSGSYTLNDLDGILTTLAQTLPIRMARLGSRVIALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAQ5</accession>
    <name>A0A1W1IAQ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative Ferric iron uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_3913</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3913"/>
    <dbReference type="EnsemblBacteria" id="SLM50080">
        <property type="protein sequence ID" value="SLM50080"/>
        <property type="gene ID" value="NSJP_3913"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3913"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030148">
        <property type="entry name" value="Fiu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF68">
        <property type="entry name" value="PTHR32552:SF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07660">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0798">TonB box</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012890394" evidence="9">
        <location>
            <begin position="31"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="STN" evidence="10">
        <location>
            <begin position="66"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM50080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="830" mass="90584" checksum="B35F3576FE310553" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAS0</accession>
    <name>A0A1W1IAS0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative RNA polymerase sigma factor FecI (Sigma-19)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3925"/>
    <dbReference type="EnsemblBacteria" id="SLM50092">
        <property type="protein sequence ID" value="SLM50092"/>
        <property type="gene ID" value="NSJP_3925"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3925"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="115"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="172" mass="20100" checksum="D572600A5A07C2E6" modified="2017-06-07" version="1">MTLSYAQIEHLFHQYRDELTRRLLTMVQSRETAADLVQETYLRLLGLADRQVVEQPRALLHRIATNLAIDHARREKNRLHDSGDAEATLNVASPVPSQERQLQAKQRFHRFLQSTEVLPPRTREAFLLYRVYGYTYREIARRMGISESAVEKLLMRALDQFCRSVETQDSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB89</accession>
    <name>A0A1W1IB89_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_4150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4150"/>
    <dbReference type="EnsemblBacteria" id="SLM50317">
        <property type="protein sequence ID" value="SLM50317"/>
        <property type="gene ID" value="NSJP_4150"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4150"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="605" mass="67764" checksum="1ED0CC1F45694F12" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBD2</accession>
    <name>A0A1W1IBD2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4133"/>
    <dbReference type="EnsemblBacteria" id="SLM50300">
        <property type="protein sequence ID" value="SLM50300"/>
        <property type="gene ID" value="NSJP_4133"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4133"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="19"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="380" mass="41680" checksum="8C754F15F2432F1F" modified="2017-06-07" version="1">MRIAYLALEAPREGQASYVHVVEIIEGLRRRGHVVELFAPSYSDRWIRPSLAGRLWEHLLIQLRLASRVRQYQLIYVRAHPMAALAARAARIFQVPVVHEVNGIYEDIFVGYPTAARWRSLVTRLWRTQYRHAAGLITVTPQLAGWVKQESGGHQPLSVIPNGANTRLFSPERERYEGLPGRYVVFFGGLAHWHGISTLVAATGDASWPADVSLVIVGDGSGTSTLEQAARDNKKLVLLGRRPYAEVGSVVAGALAGLVPISNPGGRSMTGLAPLKLFETLACGIPAIVSDFPYQAELVRSNHCGLVFPADDGKALAQAVSDLARSPAAAAEMGRRGLDLIRREHSWDARAAQTDMFLHQVVASFDRRHPDRLSARASGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBF8</accession>
    <name>A0A1W1IBF8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative tonB-dependent receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NSJP_3936</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50103">
        <property type="protein sequence ID" value="SLM50103"/>
        <property type="gene ID" value="NSJP_3936"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3936"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030149">
        <property type="entry name" value="FcuA/FatA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF82">
        <property type="entry name" value="PTHR32552:SF82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0798">TonB box</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="STN" evidence="9">
        <location>
            <begin position="70"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM50103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="855" mass="92265" checksum="269F27074CC2AE85" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBM1</accession>
    <name>A0A1W1IBM1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Asparagine synthetase</fullName>
            <ecNumber evidence="7">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_4134</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50301">
        <property type="protein sequence ID" value="SLM50301"/>
        <property type="gene ID" value="NSJP_4134"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4134"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="6">
        <location>
            <begin position="2"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM50301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="665" mass="74504" checksum="82296A8D2F1E35B4" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBR8</accession>
    <name>A0A1W1IBR8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50213">
        <property type="protein sequence ID" value="SLM50213"/>
        <property type="gene ID" value="NSJP_4046"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4046"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013139605" evidence="1">
        <location>
            <begin position="22"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="502" mass="56267" checksum="630555FB4A8575A9" modified="2017-06-07" version="1">MKITSRLIPSVLCAAVSWVGAAGCTSVPADHGNPTIMGPLRLLKSNPRYFIDPAGHPVYLTGSHHWFSFQDGGKSDPPPLFDYSEYLSFMERHNHNFIRLWVKEQARWFPSADLHSDYYLSPMPYNRIGPGMARDGKPKFDLDQFNPAYFDRLRDRVVAAGARGIYVSIMLFNGWGVMPFEDLGLPGNPWLGHPFHRDNNVNGVDGDINGNDQGDEVHTLGSDPRQVTRLKRQEAYVSKVIDTVNDLDNVLYEVGNEIVEASTEWQYHIVRYVKAYEAVKPKQHPVGMTFQGMQGGAAPHNYSLWDSPADWISPGTREAPGDPLTMSYREDPPVASHAKVIITDTDHLWGVGGDRVWVWKSFMRGLNPIYMDPYGRQDQPKADESARRAMGDTLIFAGQINLALMEPRPEVSSTTYCLAQQNREYLIYVPPPSEASSTTQSSRTITVDLPAREFHMNWFNPETGERMSGNLVARVGGNLFTVPYPGDAVLHLVSIEDRAGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZR0</accession>
    <name>A0A1W1HZR0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46212">
        <property type="protein sequence ID" value="SLM46212"/>
        <property type="gene ID" value="NSJP_0040"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0040"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="66" mass="7473" checksum="08761602DD76E0D5" modified="2017-06-07" version="1">MKLSPGFPKFTNEVQHLLDKVLQWDDTMHSSPWKTGVRLPGLATPGKQSAKSQQLWIARHRPFCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZS3</accession>
    <name>A0A1W1HZS3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46260">
        <property type="protein sequence ID" value="SLM46260"/>
        <property type="gene ID" value="NSJP_0088"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0088"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="107" mass="12347" checksum="44BBEF74F54E67CE" modified="2017-06-07" version="1">MTDQELNRAVQYVIASTSYGRDTVESVLRTGFRELTELALQTTRRFERDSLLEYVAQWTIKQTGQPEPLVREILACAGRWMDEACEEVAARNNDENRSAHDEHGRMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZW5</accession>
    <name>A0A1W1HZW5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46274">
        <property type="protein sequence ID" value="SLM46274"/>
        <property type="gene ID" value="NSJP_0102"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0102"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="84" mass="9612" checksum="B3166035858FB3E2" modified="2017-06-07" version="1">MGFEPNYIVVDGQTFSKAKLALDNHVYKNCQIDDCDLYYSGGQYELIDTHITNSRLVLNHPAKGIYHSLQIFKMKSPGSRIIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I008</accession>
    <name>A0A1W1I008_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin-guanine dinucleotide biosynthesis protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mobB</name>
        <name evidence="2" type="ORF">NSJP_0163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0163"/>
    <dbReference type="EnsemblBacteria" id="SLM46335">
        <property type="protein sequence ID" value="SLM46335"/>
        <property type="gene ID" value="NSJP_0163"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0163"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004435">
        <property type="entry name" value="MobB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03205">
        <property type="entry name" value="MobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00176">
        <property type="entry name" value="mobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MobB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="174" mass="19013" checksum="C1701DF205F1D5F6" modified="2017-06-07" version="1">MVVPIVCFVGKSNSGKTTFIERIIPELVKAGYKIATVKHAGHGFDLDTEGKDSWRHKQAGASSVVILSKGSMAMFADVSDQLTVEDVRGRFLDESYDLILAEGWKHEGHPKVVIVREQIGEIPISQEGLLAVVSDKPVDLGVPTFDLNDVTGVAALIIKRFPLRRPRAAHELEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I053</accession>
    <name>A0A1W1I053_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0175"/>
    <dbReference type="EnsemblBacteria" id="SLM46347">
        <property type="protein sequence ID" value="SLM46347"/>
        <property type="gene ID" value="NSJP_0175"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0175"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025194">
        <property type="entry name" value="DUF4115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13464">
        <property type="entry name" value="DUF4115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4115" evidence="3">
        <location>
            <begin position="242"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="316" mass="33959" checksum="DF9F5433D5FD7EAE" modified="2017-06-07" version="1">MESIGDFFKQVRETKGLTIDEVASKTRIRSDFVRALEEGNFAKLPDQVFARGFVRSYARSLGLDEEDAIHRFIQSAGAFYEKQDEKERLKARQVQEERKRQANRKAVAVAIGIAIITLIFLLSREQSTVLVRRPATDLPPIASKRTSTPAPEARDAAPKPEPEPQTASTPPSKSKPADQPPPAPPKVETNAPRVSSPAPAPAVTASQPVPPAAPIPAPIGSDGPLGGISLETAPDATDQLVLDLEATELSWVVIQIDGGSPQEALLRPGEKAKWKGQDQFVLTLGNAGGVKAELNGKPQKPFGPSGKVARDIVLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I058</accession>
    <name>A0A1W1I058_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase, family 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 57 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0216"/>
    <dbReference type="EnsemblBacteria" id="SLM46388">
        <property type="protein sequence ID" value="SLM46388"/>
        <property type="gene ID" value="NSJP_0216"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0216"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="2">
        <location>
            <begin position="8"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="733" mass="83998" checksum="2C0C5EB1E9F5FF2E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0D1</accession>
    <name>A0A1W1I0D1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribokinase</fullName>
            <ecNumber evidence="4">2.7.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0177</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.15" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0177"/>
    <dbReference type="EnsemblBacteria" id="SLM46349">
        <property type="protein sequence ID" value="SLM46349"/>
        <property type="gene ID" value="NSJP_0177"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0177"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="20"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="304" mass="33767" checksum="DA95F8FE87D94837" modified="2017-06-07" version="1">MGTLLVVGSVALDTVKTPFGAVEEVLGGSATYFSTSASYFADVNLIAVVGEDFPSQHLMFLKSRNIDLAGLERRPGATFRWKGEYSHQLNEARTLDTKLNVFETFRPKIPEAYRAPDVLFLGNIDPELQLDVLNKLPRPPLVACDTMNFWINGKRDALWRVLEKVDILIINDGEARALGEDSNLVKVAQKVLARGPKHLIIKRGEYGVLMFNEKQVFGAPAFPLEDVRDPTGAGDTFAGGFLGHLAATGNRSAEAFKQAIVFGSVMASFTVEAFSLDRLRILDYKEIQERFKAFKRLTHFEDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0J3</accession>
    <name>A0A1W1I0J3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46497">
        <property type="protein sequence ID" value="SLM46497"/>
        <property type="gene ID" value="NSJP_0325"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0325"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="101" mass="11185" checksum="4312B023119E04C9" modified="2017-06-07" version="1">MGYSDDELKKLERALTEAFHVPINRPASQGEMARRVMRTLRRPADIPVSGLLDQFVWRVATIAAAVVLVVSMLTVHVSRTSTGESTLLLAEEFETTPLFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0K7</accession>
    <name>A0A1W1I0K7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0354"/>
    <dbReference type="EnsemblBacteria" id="SLM46526">
        <property type="protein sequence ID" value="SLM46526"/>
        <property type="gene ID" value="NSJP_0354"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0354"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="244" mass="27518" checksum="CC92A600E6B68DFD" modified="2017-06-07" version="1">MKGQDEKAVDAMKDGVVVRPVNSVYRRDSAFSYACHACSRCCHDKVIRLNPYEVDRLAMNRGITTTEFLSRYTESNGTSLRRVEEGACVFLSRQGCGVHEDRPLVCRLYPLGRRVTAEGEETFHELTPHPRTEGEYGRGGTVQDFLTTQGAQPFIEAVDRYVELVGSMAVKLHSVAANDHDLLAEVKQATEGVDQRHDAILRDWTDMDSVLTQYCLERGMTVPDDVTERMPLHIRAVTERLDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0T5</accession>
    <name>A0A1W1I0T5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na+/solute symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_0443</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0443"/>
    <dbReference type="EnsemblBacteria" id="SLM46615">
        <property type="protein sequence ID" value="SLM46615"/>
        <property type="gene ID" value="NSJP_0443"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0443"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="501" mass="53138" checksum="1B632EAC37EB20FF" modified="2017-06-07" version="1">MILTFVILYLAVSVGVGLHAARRVHDTKDFAVAGRSLPLPIVAATVFATWFGAEALMGMSATFVKEGLRGVVADPFGSTLCLVLAGLFFAPRFYRLNLLTVGDYYRLRYDRRVEVLCTLCIVASYVGWVAAQFKVLGLVLNVVTQGAVSQQAGMVIGAAIVLTYTTFGGMFSVAILDFVQLSVIIGGLLYIVSVVSDLAGGAGAVLSHAAQAGKLEFFPAASLDAWIPFIGAGVTMMLGSIPQQDVFQRITSAKDERTAVRGSLAGAALYFSFCFVPMFLAYAALLVDPDRFGTLLREDSQLVLPTLIVEYTPAVAQILFFGAVLSAVMSCSSATLLAPSVALSENVLKGLMPGLDERGLLRMMRIVLVGFAVIVLAIAISSDASIYQLVVNTYKVTLVAAFVPLAAGLYWRGATIVGALCAIGLGLATWIAGEVLSSEQPVWPPQLLGLLMAGVGMVIGSKAHLIYDRADMVREGSAETGETQEMVESRVTKSPRRPPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0U2</accession>
    <name>A0A1W1I0U2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">L-lysine 2,3-aminomutase</fullName>
            <ecNumber evidence="10">5.4.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">kamA</name>
        <name evidence="10" type="ORF">NSJP_0425</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="5.4.3.2" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0425"/>
    <dbReference type="EnsemblBacteria" id="SLM46597">
        <property type="protein sequence ID" value="SLM46597"/>
        <property type="gene ID" value="NSJP_0425"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0425"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050066">
        <property type="term" value="F:lysine 2,3-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025895">
        <property type="entry name" value="LAM_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="PTHR30538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12544">
        <property type="entry name" value="LAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004911">
        <property type="entry name" value="DUF160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00238">
        <property type="entry name" value="TIGR00238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="89"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004911-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR603739-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM46597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="396" mass="44319" checksum="6227902A53F10BF2" modified="2017-06-07" version="1">MEEWRQILADSIVKPKDLADRFGLDAKEIEEIVGPYPMRITPTVLNTIRAKGDAIWRQVVPDAAELADIDAEDDPLEEDLMSPVPHLVHRYPDRVLLMVTNQCPIYCRFCTRKRLVGKPGFLKKGELDRAIAYLRAHSEVRDVILSGGDPLLLPDHLLERILKALRTIPHLELVRIGSRVPGTLPERITPALCEIVKKYHPIYMNLHFNHPDELTPEVKAACGRLADAGVPLGAQTVLLKDVNDDPEIMRRLMHQLLLARVKPYYLYQADLTKGTNHFRTKVETGLNIIKALQGHTSGMAVPHFVIDAPGGGGKIPLLPDDYLVRMNDDEAVLRNYENKRFSYPQSKATGGRELPMVGARASYQDDADAFPSYGDSYPDRDGYAAWGNSCGGDMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0W1</accession>
    <name>A0A1W1I0W1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46617">
        <property type="protein sequence ID" value="SLM46617"/>
        <property type="gene ID" value="NSJP_0445"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0445"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="17"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="134" mass="15139" checksum="9CF6FF6479938139" modified="2017-06-07" version="1">MGNQKTKDISMADRLIAYEHETWSLIKRNDLNGFASYLSEDFYDIFPDGKERTKSELLDFLGDADLKDYRLGNFRVTLLTRDAAIVTYHVDARAIIQGKEIAMRNSVTSGWAKRGGRWLNVSAVASAQPPHNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0X6</accession>
    <name>A0A1W1I0X6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Cell division protein ZapB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46656">
        <property type="protein sequence ID" value="SLM46656"/>
        <property type="gene ID" value="NSJP_0484"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0484"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090529">
        <property type="term" value="P:cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009252">
        <property type="entry name" value="Cell_div_ZapB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06005">
        <property type="entry name" value="ZapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="84" mass="9969" checksum="30BCDFCD796421AA" modified="2017-06-07" version="1">MALDRLDALETRVKDLVRLVHELKKRNTLLEDDLKSLRERLAEQSDSNKRWERERLDIKARVEKVLGEIELLECMEDPKEVALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I107</accession>
    <name>A0A1W1I107_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">atpB</name>
        <name evidence="13" type="ORF">NSJP_0492</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0492"/>
    <dbReference type="EnsemblBacteria" id="SLM46664">
        <property type="protein sequence ID" value="SLM46664"/>
        <property type="gene ID" value="NSJP_0492"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0492"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="PTHR11410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM46664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="250" mass="27163" checksum="6FD312ADF7ACDD9A" modified="2017-06-07" version="1">MEESPLHPFELHNFIPVQFGGLDISINKAVIMMWVVVAMVSLLMIMAGSARQLVPGKLQSLGEILVDFIRGIILDTMGKEGMKFFPLIATLFLFILFCNLLGLIPGTYTVTSQIVVTAVFAITVYALSLLMGLLIHGVKFIPGILVPPGTPWWLIPLMVPIEFVSQVARPVSLAVRLFANMTAGHTILGVLFGLAISGGLLIGWLPFAFTIAMNGLEVGIAFIQAYIFTVLTCVYLGDAFHLHGSEDHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I133</accession>
    <name>A0A1W1I133_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0538"/>
    <dbReference type="EnsemblBacteria" id="SLM46710">
        <property type="protein sequence ID" value="SLM46710"/>
        <property type="gene ID" value="NSJP_0538"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0538"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039068">
        <property type="entry name" value="PqqC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40279">
        <property type="entry name" value="PTHR40279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="244" mass="27882" checksum="02E7C2EFBF7713DB" modified="2017-06-07" version="1">MTFYQEMRSLVLGHGAINNAYLDRFQSGELTDAELTEFAIEFYNFARFFPRILVTQLVNTEDEKVAEELTKVLYSELGDGEARYRHELLYRDFLRSIGIGVHEAMSRPMLPSTHRYIEGMEQLYGDGNHAKALGASFGLENMAITMWDHLIPGLNHLRSGRYPRMDVTYFTFHRELEATHEEAMEHAVEAIEGTNGTGLSDEEKDDFQSGVNAVLGYLEGFWMGLARRRAPDREPQDTMHPHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I154</accession>
    <name>A0A1W1I154_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2'-deoxycytidine 5'-triphosphate deaminase</fullName>
            <ecNumber evidence="1">3.5.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dcd</name>
        <name evidence="1" type="ORF">NSJP_0427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.4.13" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0427"/>
    <dbReference type="EnsemblBacteria" id="SLM46599">
        <property type="protein sequence ID" value="SLM46599"/>
        <property type="gene ID" value="NSJP_0427"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0427"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009394">
        <property type="term" value="P:2'-deoxyribonucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010550">
        <property type="entry name" value="dCTP_deam_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06559">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="384" mass="42998" checksum="5D67231D7A74B689" modified="2017-06-07" version="1">MAAAPAQGILPYQQITRLIAGGSITAPVAIEDRQIQPASLDLRLGKKAYRLISSFLPELSPISSRLDVMDFYHSDLVMYEMDLSGGAILEKGHVYLVPLLESLQLPKTLRARANPKSTTGRLDVFTRIVTDLNTGFDEIRAGYHGPLFLEVVPRSFAIKVKTGQSLNQIRFIRGEATAPDAALERLHRQEPLLYHNAPKRKAVSAKEFRTDHGLFLRIDLKGEERTGNAVIGYRAKKNSHVIDLSKVGYYAAADFWEPLYRHRQDSLLLEPEEFYILASKERICVPPDYAAEMVAYEAACGELRTHYAGFFDPGFGYGADGEIAGTQVVLEVRPHDVPFLIHDGQTFFKVIYDRMLDVPSRLYGVGLGSSYQRQALTLSKHFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I164</accession>
    <name>A0A1W1I164_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0437"/>
    <dbReference type="EnsemblBacteria" id="SLM46609">
        <property type="protein sequence ID" value="SLM46609"/>
        <property type="gene ID" value="NSJP_0437"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0437"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="142"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="355" mass="38214" checksum="7D7BFF050E62C218" modified="2017-06-07" version="1">MHNLTDSAVVSALAPTKVVILGAGRGGTALLDLLHQISAIEILGIADRDRRAPGLQRARDLRIPVTDRAEDLIAKHDVNLIMDVTGDPHMEHVIRLHRHPETDVLSGTASRVLWELVRHEARLQAELFHAEKMAGVGNFAAGIAHDINNPLQLILGLAENLAEERDLRTIHEQAKDIIEAVKRTSAICRDLTQYARKSSVNGDSQVNLNLRLDEALKIARYAASFHDITVVKRYGTGAVTTGNPDELLHVFVNLITNAVHAMDRGGGTLTLTTEAAGDAIRASIADTGCGMSSEVAGRIFEPFFTTKGPGKGTGLGLYNVKTIVNRMLGTITVDSHEGTGTTITLSFPPPRGVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1C5</accession>
    <name>A0A1W1I1C5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Lytic murein transglycosylase (Modular protein)</fullName>
            <ecNumber evidence="6">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_0497</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase Slt family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46669">
        <property type="protein sequence ID" value="SLM46669"/>
        <property type="gene ID" value="NSJP_0497"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0497"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025392">
        <property type="entry name" value="DUF4124"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13511">
        <property type="entry name" value="DUF4124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013343132" evidence="3">
        <location>
            <begin position="42"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4124" evidence="5">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="4">
        <location>
            <begin position="87"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="237" mass="26727" checksum="579E40E1D5747440" modified="2017-06-07" version="1">MNQFDLGHHEPCRYRTRLRVAATALAACSSLALFVPSHASAEIYQYVGPNGSISLTNVPSDSRYRRVDIDAAQFHTVLPEHELEPLIRRHSSQHQLHPALIRAVIKAESNFDPRAVSRAGAVGLMQLMPQTAVRMDVRDLYDPEENVAGGTKYLRQLLDRFHGNLPLALAAYNAGEHVVERYQALPPIDETRQYVRKVLRYYRTFLVRDGVITERPLNRYAPPSSAATPETFEPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1G6</accession>
    <name>A0A1W1I1G6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46850">
        <property type="protein sequence ID" value="SLM46850"/>
        <property type="gene ID" value="NSJP_0678"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0678"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="178" mass="20016" checksum="2F4B1DD97FDB1669" modified="2017-06-07" version="1">MISRVLLIGLFALPVVLVERDVAFGEAGGTVSVTMHPALGKASLFLAAGDYRRALEACQREIDEAPSAASYIHLTYVYQAIDAYLEHLSREERWMAVEQLYLNLAYRDTEDLVDPPGGLARIAKEMIQSSVRQQSDVSAAMAIRLDNAESDRLWQEQAQWRAANPKTWWQGVPKPWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1I8</accession>
    <name>A0A1W1I1I8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbohydrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0669"/>
    <dbReference type="EnsemblBacteria" id="SLM46841">
        <property type="protein sequence ID" value="SLM46841"/>
        <property type="gene ID" value="NSJP_0669"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0669"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="165" mass="19160" checksum="E6E228F36A31C206" modified="2017-06-07" version="1">MNNSAVGKMRNHFIEQPYSKMALPDPDWLPIRRLADVEVTSEDPARPIENVFLRDQSFGWRARGPGQQFIRLRFNRPLTIKRIRLRFAESVSQRTQEYSLRWSSNEPSSPRHIVRQQWNFSPPCATSQIEDHYVELAAAVMLELNIIPDIRGSSATASLLQWWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1S0</accession>
    <name>A0A1W1I1S0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46956">
        <property type="protein sequence ID" value="SLM46956"/>
        <property type="gene ID" value="NSJP_0784"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0784"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="46" mass="4889" checksum="AF343902F0CC2C2C" modified="2017-06-07" version="1">MALPVLREAMHVYRLTVIKASVGSFPSVTLMIVAAFVLATMLPATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2E6</accession>
    <name>A0A1W1I2E6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YceI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0821"/>
    <dbReference type="EnsemblBacteria" id="SLM46993">
        <property type="protein sequence ID" value="SLM46993"/>
        <property type="gene ID" value="NSJP_0821"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0821"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012009148" description="YceI domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="YceI" evidence="2">
        <location>
            <begin position="31"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="203" mass="22430" checksum="658816AC0A33CD7B" modified="2017-06-07" version="1">MVCGRLTRRSMALITVLFLGIPLSGHAETARWNVDPEHSTIEFRVSHMVISKTTGRFMDYTGFIEMDADAGTVKTIEATIKAASVNTNHEKRDAHLRNPDFFDVEKHPAITYRMKSAKKAGDGYTAVGDLTVRGVTKEITLTGNFNGATKDPWGNQRAGFTGEGKVNRKDYGMVWNKTLDSGGLVVGDEVFIKLDIECIKEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2L0</accession>
    <name>A0A1W1I2L0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Cytochrome c552</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_1074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1074"/>
    <dbReference type="EnsemblBacteria" id="SLM47246">
        <property type="protein sequence ID" value="SLM47246"/>
        <property type="gene ID" value="NSJP_1074"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1074"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012754590" evidence="5">
        <location>
            <begin position="24"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="28"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="119" mass="13377" checksum="74B50D5F040BF742" modified="2017-06-07" version="1">MPRWLWGSCAVLLILATPLALVAQDYPPDVTRGKEVYGRHCQRCHGPSGWGDGPEAASLRMKPADFHRFGSYLKSDEDLLRTVEHGIVFSPMHAWRGQLTDGEMQDVVAYIRVLSQQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2R7</accession>
    <name>A0A1W1I2R7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Multihaem cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1093</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1093"/>
    <dbReference type="EnsemblBacteria" id="SLM47265">
        <property type="protein sequence ID" value="SLM47265"/>
        <property type="gene ID" value="NSJP_1093"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1093"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="29"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="139"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="241"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="375"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="468" mass="50960" checksum="027CE29BA33AE87F" modified="2017-06-07" version="1">MRATRGMLISGVVFVLVGLISTPRLLFGSDHQRAKELIEQACVGCHRLQGTAESRFILRAPDLIWAGSKYQRPWLIRWLTGKEAPLYAKGYRWDLNEGAMKHPIVSETDANAMADYFEQHNKDPRVKVGAFDASKVSKFEMTFGGMAYKAHACLGCHTIEENGKLIGGPQSTALQNAGQRYNADWLYRFGQNPQDFIIHTGEFLADATDPQLRAVIGYLAVQGVKDFVYYEPWTSREFADASVDRGKQVYKEYCAQCHGVTGKGDGPAASGLEPKPAIHANIPFEKLPIDYLYNVINHGGAAMGKSPSMPYWNLTIGQQGVADVIAYLKATFKGAPDLAAATSGSQGDACVQPRKTVKAPDGILSKTNPIPASSDMINAGKTLFLKTAQPVACAMCHGELGDGNGFMGAALVPSPRNFTCGAMMKDLPDGQLFWIIKNGSPGTGMMSFTALPDDQVWQLIHYIRSLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I336</accession>
    <name>A0A1W1I336_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Relaxase/mobilization nuclease domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47412">
        <property type="protein sequence ID" value="SLM47412"/>
        <property type="gene ID" value="NSJP_1240"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1240"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="196" mass="23472" checksum="1A1E1A83319E83DC" modified="2017-06-07" version="1">MPQGLLDSNNRDPLNYSLREWQQAKRQGYDPKALQSMFQNCWAVSDNRPSFEHALQRYGLYLAKVDRRGYVAIDYRGEVYSLSRWLKVKTKALQERLGPAEVLPGTQEVKAKIAERMTDKLKTYIQETQVRLKQQVQPFIQKKRSLQHQHQNERSQLQQKQEKRWQQKSFERSQRLPKGFKEIWFRITGKYSKIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I339</accession>
    <name>A0A1W1I339_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47381">
        <property type="protein sequence ID" value="SLM47381"/>
        <property type="gene ID" value="NSJP_1209"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1209"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012529056" evidence="2">
        <location>
            <begin position="26"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="278" mass="29604" checksum="280CAE93D36F1C61" modified="2017-06-07" version="1">MKIVHSAFVFTIGFTVGLSAATTMAADLQPDSPTTGAGTVQSGSREQVISQQTETNLAGNRLVTGRVKEIRGNQMEVDIGNPKSLYIPLKPAADKGQTFKPGDIIIITLNDNNALVDYHRPGETSHHQVIEGKLQTPLTVGLDKAVIVTPEGTKTFVVAERAKSTLASIPIGVSAVFLADETGQLVDAQPGGLSAAADAAKSHRAPIKGAHEQLRAVFRGAGPEGRLKISEGGREREVQFRPPLEKLDRIKPGQEVVLLLDEQGYVLEIATPDVIPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3A4</accession>
    <name>A0A1W1I3A4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1187"/>
    <dbReference type="EnsemblBacteria" id="SLM47359">
        <property type="protein sequence ID" value="SLM47359"/>
        <property type="gene ID" value="NSJP_1187"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1187"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011495">
        <property type="entry name" value="Sig_transdc_His_kin_sub2_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07568">
        <property type="entry name" value="HisKA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="29"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="402" mass="44850" checksum="EF2D6B9033D15D77" modified="2017-06-07" version="1">MTRHTDEPQGDRPVRLSMDAKGGIKDRANILLVDDDARNLDVLESILESPDHRLVRARTADEALLSLIAEEFAVIVLDVRMPEVSGYELAQLIKQRKRTQHVPILFLTAYYREDADILQGYGAGAVDYLSKPVNPLILKSKVGVFVDLFRKTRALATMNRAMEAEIEERLKQLKASLHEKEILLKEIHHRVKNNLQVISSLIDLQADRLTDPVVRALFKDARDRVRSMALVHEKLYQSPDLAHAELGAYIRNVMDELFLAHGATSSKVRLRMELDPVLLPVDMAIPCGLILNELATNSLKHAFVGRESGAIVIQLICTESHAVRLVFHDDGRGLPEGLDWQAAGSLGLRLIRMLSRQLNADIALRNGSGTTFELQFNLPAGSRGPSSETKAVEDAKGQHSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3I6</accession>
    <name>A0A1W1I3I6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47449">
        <property type="protein sequence ID" value="SLM47449"/>
        <property type="gene ID" value="NSJP_1277"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1277"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011460">
        <property type="entry name" value="DUF1566"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07603">
        <property type="entry name" value="DUF1566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="145" mass="15798" checksum="452DD7E5675FAEDB" modified="2017-06-07" version="1">MNWDRNFPSATRFTILPEFNNEAVRDNNTGLVWQRTPDTTLRDWLGARTICANLVVGGATGWRLPSVFELKSLQDPSLPAPFVPTSVFTVPSNTFWSTTEVSPPPAGQAVWVVTFAGGMALTNGTAGGQTFLAWGVRGPMHPDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3P9</accession>
    <name>A0A1W1I3P9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">rpe</name>
        <name evidence="15" type="ORF">NSJP_1450</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1450"/>
    <dbReference type="EnsemblBacteria" id="SLM47622">
        <property type="protein sequence ID" value="SLM47622"/>
        <property type="gene ID" value="NSJP_1450"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1450"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="177"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="199"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SLM47622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="226" mass="23864" checksum="3C318736DA626A46" modified="2017-06-07" version="1">MTRPARIAPSILSADFARLADEVAAVERGGADFLHVDVMDGHFVPNLTVGPPIVESLKKVTKLPLDVHLMITNADAFIPEFAAAGASYLTVHVEACPHLHRTVQLIKEHGVKAGVTLNPATSLRTLDEILPDVDLVLIMSVNPGFGGQKFIDHCLQKVANARRMLDQIHSHALLEVDGGIKVDNAGRILAAGAEVLVAGSAVFSSPDYGATIAALRAAGQPASAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3U0</accession>
    <name>A0A1W1I3U0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47676">
        <property type="protein sequence ID" value="SLM47676"/>
        <property type="gene ID" value="NSJP_1504"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1504"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="134" mass="14823" checksum="9076D581F52029A3" modified="2017-06-07" version="1">MGHDTQGLIRVLIVDDIKEMRESLRSILIAYPGMEVVSEACDGEEAVLRVPQVKPSVVVMDINMPRLDGIRATVKIKQIFPHIVIIGISAYATDETCQVLRLAGTATVISKDMAVNQLRTEILTSVHRRSTAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I492</accession>
    <name>A0A1W1I492_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH:ubiquinone oxidoreductase, membrane subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nuoM</name>
        <name evidence="7" type="ORF">NSJP_1623</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1623"/>
    <dbReference type="EnsemblBacteria" id="SLM47795">
        <property type="protein sequence ID" value="SLM47795"/>
        <property type="gene ID" value="NSJP_1623"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1623"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000260">
        <property type="entry name" value="NADH4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01059">
        <property type="entry name" value="Oxidored_q5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_q5_N" evidence="6">
        <location>
            <begin position="63"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="5">
        <location>
            <begin position="128"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="518" mass="56485" checksum="992EA2CA07E40F15" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4F6</accession>
    <name>A0A1W1I4F6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47821">
        <property type="protein sequence ID" value="SLM47821"/>
        <property type="gene ID" value="NSJP_1649"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1649"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012415915" evidence="1">
        <location>
            <begin position="28"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="518" mass="53548" checksum="FF5153EBA5906766" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4J4</accession>
    <name>A0A1W1I4J4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="9" type="ORF">NSJP_1754</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1754"/>
    <dbReference type="EnsemblBacteria" id="SLM47926">
        <property type="protein sequence ID" value="SLM47926"/>
        <property type="gene ID" value="NSJP_1754"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1754"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="8">
        <location>
            <begin position="104"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="263" mass="27653" checksum="BE9C6E798F0CC018" modified="2017-06-07" version="1">MKFDLAVTVREKTGKGAARQLRREGKVPAVLYGQGECLLLTIEPEPLVKILKSQAGSTALISLSISGVKSNPKRTALLRDFQVDPVEGHVLHADLFEISMEKPIRVKVPVHVIGGTPAGVKEGGILHFNMRELSVECLPAAMPDHIEVDASPLAIGQGIHLKDIAKRDGVRYLDDPEQMVVSVAVPMSDAKLEALLTSQAAGPEGAKEPEVMAKGKIAAEGAEGAEASKTAAPAAAADAKAGEKKEAAAAAPKAEKKEAEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4P1</accession>
    <name>A0A1W1I4P1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribonuclease III</fullName>
            <shortName evidence="6">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">rnc</name>
        <name evidence="11" type="ORF">NSJP_1773</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1773"/>
    <dbReference type="EnsemblBacteria" id="SLM47945">
        <property type="protein sequence ID" value="SLM47945"/>
        <property type="gene ID" value="NSJP_1773"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1773"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="7"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="9">
        <location>
            <begin position="166"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM47945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="235" mass="26181" checksum="D1D653297E01AE84" modified="2017-06-07" version="1">MTPTNSIDVLQQSLAYQFADAALLQEALTHSSYVHERRPIGAAHNERLEFLGDAVLSLVISEYLASRLSHCSEGALSKLKAKLVSESSLVRVARRIKLGEHLRLGRGEERSKGREKQSLLSDAVEAVIAAVHLDGGYGASRAVTLRLFEDELRSSTDQGTYPGAEDFKTQFQEWCQKRHEMLPRYDIVRETGPDHNKVFEVVVVVKDEPVGQGTGRSKKEAEQSAARQALQRLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Q3</accession>
    <name>A0A1W1I4Q3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47998">
        <property type="protein sequence ID" value="SLM47998"/>
        <property type="gene ID" value="NSJP_1826"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1826"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="142" mass="15574" checksum="91B0E0FC881C8589" modified="2017-06-07" version="1">MTLTDAKRGIGSQLMASMEVEEMVVLDNGLGILFFFEEGLAALHNDVRIVVLLDRIPEKNRLVRSAEGLLRRLVSALVRARTTHEQAKHDDGQDEPSSIACHSAEIIAKPTHHNLGILRPGANLTQVSCSRRCGQLQRSPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4V4</accession>
    <name>A0A1W1I4V4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dihydroflavonol-4-reductase</fullName>
            <ecNumber evidence="2">1.1.1.219</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dfrA</name>
        <name evidence="2" type="ORF">NSJP_1681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.219" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1681"/>
    <dbReference type="EnsemblBacteria" id="SLM47853">
        <property type="protein sequence ID" value="SLM47853"/>
        <property type="gene ID" value="NSJP_1681"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1681"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045552">
        <property type="term" value="F:dihydrokaempferol 4-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017829">
        <property type="entry name" value="Hopanoid-assoc_sugar_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03466">
        <property type="entry name" value="HpnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="328" mass="35588" checksum="6A18327BC984BAE2" modified="2017-06-07" version="1">MKVLVTGASGFVGGAVARALVQAGTEVRLLVRADSDRQNFDGLPVEPVTGDLRDQASLRRALSGCRQLYHIAAHYALWAKDPSIFYDVNVTGTKNMLEAARSVGIERTVYCSTIGAIGLPPEGGVGTETTPVSLDQMAGHYKRSKFLAEQEVLKLAKDGLPVVIVNPSAPVGAGDVKPTPTGQVIVDFMKGRMPAYIETGMNLIDVDDVAAGHLLAMEKGRQGERYILGNKNLMLREVFEILSRLTGVKAPTLRLPRLAVLPLAYGNQWIAALTGRTPRIPLEGVKMAKYKMHYDCSKALRELGLPQTPPEVALEKAVRWFRTHGYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4X3</accession>
    <name>A0A1W1I4X3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47873">
        <property type="protein sequence ID" value="SLM47873"/>
        <property type="gene ID" value="NSJP_1701"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1701"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="181" mass="19609" checksum="9476EFB862F8FA5B" modified="2017-06-07" version="1">MVGKPFECLHYNMIRSDAGLGQKKNLFRPLLNRDDWLTSFSTLGHNAPHVVVVCNAAPVRFCSRSLRASRSPMHLVQDFDEETARGRRTIRSLHLPKVHLSTHHPVGAETPSIAKTLVHDAEASGPAHPSTHRTVGTVVSALCGRVSDARMPLECDSPPVSSTSPDRSGTTLSPESGPSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I527</accession>
    <name>A0A1W1I527_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized endonuclease (Modular protein)</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48100">
        <property type="protein sequence ID" value="SLM48100"/>
        <property type="gene ID" value="NSJP_1928"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1928"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012912930" evidence="1">
        <location>
            <begin position="23"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="2">
        <location>
            <begin position="21"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="216" mass="24509" checksum="2D3EFA1192BA9991" modified="2017-06-07" version="1">MSGLLRLLLSIALLFTPSVAWADTGKVIAVLDGDIIEVIHGHQVERIRLNGIDRPEKGQDYGQRAKRFTQELVEQKEVRVETRGLDKYGRTIGDVFLMDGTHVNRELVNAGLAWRFCRHSSDNQLKQLEEESREAKRGLWVDPVPIPPWVYRKLQRKQVPDVADFDCSGLPVPTALWNNCCQPRRRILDGGFSINSCSIENRGNLFSPRLLAPPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I574</accession>
    <name>A0A1W1I574_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate:ferredoxin oxidoreductase delta subunit</fullName>
            <ecNumber evidence="2">1.2.7.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">porD</name>
        <name evidence="2" type="ORF">NSJP_1995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.1" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1995"/>
    <dbReference type="EnsemblBacteria" id="SLM48167">
        <property type="protein sequence ID" value="SLM48167"/>
        <property type="gene ID" value="NSJP_1995"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1995"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019385">
        <property type="term" value="P:methanogenesis, from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003704">
        <property type="entry name" value="CO_DH_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02552">
        <property type="entry name" value="CO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LRRNT_2" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="210" mass="23279" checksum="365B34ABB5065057" modified="2017-06-07" version="1">MSQYRVLPGPEHFLPPAAASMGVYLPNPGEAHINGVIASEEKAYEEAARQFLMASVPTIFPGPLVLWAWNEKAAKKATAIRHLYNTLKECVQPGQKAMLIPMPDYRPKYPKINPEVEINPNHPNLTIWHNKIDCCMFVGVHCHQANLSLKIIRGGTSCYTIAMCAQAGHEDAMLSFRDASVEKIMTLADWIKKLKGTVKPRLTTKNGATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5H2</accession>
    <name>A0A1W1I5H2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48129">
        <property type="protein sequence ID" value="SLM48129"/>
        <property type="gene ID" value="NSJP_1957"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1957"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="81" mass="8773" checksum="06468CED4FA55121" modified="2017-06-07" version="1">MFISAPGIIPLFDLVAQPYNTVVADPAMPGRERVFHESEEGESNEPISMPGCLCLCAVQCRYVGIGTGCHLAPRRSPPESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5X3</accession>
    <name>A0A1W1I5X3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_2097</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2097"/>
    <dbReference type="EnsemblBacteria" id="SLM48269">
        <property type="protein sequence ID" value="SLM48269"/>
        <property type="gene ID" value="NSJP_2097"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2097"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="232" mass="25153" checksum="7D1C71A3AAC26294" modified="2017-06-07" version="1">MLRLEQVSKIYHRGSASIIGVDRVSLEVAAGEFCAFMGPSGCGKSTLLNLVAGLDSPTSGEIVLNGRPTARFSSDDWTRIRREEIGIVFQSFHLVPGLSAEENVAFPLLLRGERGGTMLRRVEEVLDLVGMNHRRRHRPGELSGGEQQRVAIARAVVHGPKLVVADEPTGNLDSQQGAAVVDLLRTLADQDRRTVLLATHSGEAAGSAHYVWTMRDGRLIERVASNLLSLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I681</accession>
    <name>A0A1W1I681_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rplP</name>
        <name evidence="9" type="ORF">NSJP_2345</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2345"/>
    <dbReference type="EnsemblBacteria" id="SLM48517">
        <property type="protein sequence ID" value="SLM48517"/>
        <property type="gene ID" value="NSJP_2345"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2345"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="8">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="137" mass="15332" checksum="CE02655B730D82B3" modified="2017-06-07" version="1">MLAPKKVKFRKMMKGRMRGKAYRGGNVTLGEFGLKALEPGWVTSRQIEAARIAITRYVKRGGQVWTRIFPDKPITKKPAETRMGKGKGNPEYWVAVVKPGRILYEMGGVTPEIANEAFRLASHKLPIATKCVARGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I682</accession>
    <name>A0A1W1I682_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48485">
        <property type="protein sequence ID" value="SLM48485"/>
        <property type="gene ID" value="NSJP_2313"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2313"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="118" mass="12881" checksum="95558918C4FB9EEE" modified="2017-06-07" version="1">MRDRIVTPTWRWVSTAVMAISIGLLCVPLVQAAQGRTYKVQGIVIGVTSNQSPQLIVVNTPITPKNFMTVGATVTAQTKILRGQKKVPLHSIRVGESVWLTYIKSPEGLLARMIQAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I687</accession>
    <name>A0A1W1I687_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">50S ribosomal subunit protein L30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpmD</name>
        <name evidence="6" type="ORF">NSJP_2356</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2356"/>
    <dbReference type="EnsemblBacteria" id="SLM48528">
        <property type="protein sequence ID" value="SLM48528"/>
        <property type="gene ID" value="NSJP_2356"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2356"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="PTHR15892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="5">
        <location>
            <begin position="12"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="67" mass="7452" checksum="B8EADBAF31F9A142" modified="2017-06-07" version="1">MMGAKKTGTASVRITLKRSPIGTPERHRLALRGLGLRKIRQAVVRPDTPQVRGLIHQVGYLLEVQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6A3</accession>
    <name>A0A1W1I6A3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fatty acid desaturase, type 1</fullName>
            <ecNumber evidence="9">1.14.19.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">desC</name>
        <name evidence="9" type="ORF">NSJP_2191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2191"/>
    <dbReference type="EnsemblBacteria" id="SLM48363">
        <property type="protein sequence ID" value="SLM48363"/>
        <property type="gene ID" value="NSJP_2191"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2191"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="8">
        <location>
            <begin position="64"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="324" mass="37427" checksum="11C1C57FC662CBA8" modified="2017-06-07" version="1">MSDVRTLRPTKVQHLWLTFVRWFDSWAGLEYMKTDGTPKMDWFRCIPLIAVHAMCLGVIWVGVSWVAVTVAVAFYVVRMFAITGWYHRYFSHRSFKTTRACQFAFAVLGGSCAQRGPLWWAGHHRHHHIASDTKDDVHSPRHGGFLWSHMGWFTSQTHFPPRLKGIADFAKYPELRFLDRFDILVPTIAGFGMFGLGKLLEIYAPELGTNGPQMLIWGFFISTVALIHGTCTINSLSHVYGSQRYDTGDDSRNNFILALITLGEGWHNNHHYYPASTRQGFYWWEIDITYYGLKVMEWLGLVWDIKDVPIYVREQKSKQEALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6B5</accession>
    <name>A0A1W1I6B5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Type IV pilus biogenesis protein PilN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2374"/>
    <dbReference type="EnsemblBacteria" id="SLM48546">
        <property type="protein sequence ID" value="SLM48546"/>
        <property type="gene ID" value="NSJP_2374"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2374"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007813">
        <property type="entry name" value="PilN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05137">
        <property type="entry name" value="PilN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="183" mass="20913" checksum="CCB7A58C6A7DC304" modified="2017-06-07" version="1">MIRINLLPGPKGRKAKPQYDVRAQAMLGVGLFIITIAGCWWYSASLDEELEVRQTEKSDKTKQVASLNEQVKQVADFEQRKRHLEDKNRIIDQLEKSRVGPVKVLDHVSQSLDPLKLWLVRIGVNGQNIDLEGRALSNDDVVEFVNNLRRTDYFTAIDLQESRSATESQLSVYQFKLAFKLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6B9</accession>
    <name>A0A1W1I6B9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycogen phosphorylase</fullName>
            <ecNumber evidence="4">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">glgP</name>
        <name evidence="12" type="ORF">NSJP_2319</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2319"/>
    <dbReference type="EnsemblBacteria" id="SLM48491">
        <property type="protein sequence ID" value="SLM48491"/>
        <property type="gene ID" value="NSJP_2319"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2319"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011834">
        <property type="entry name" value="Agluc_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024517">
        <property type="entry name" value="Glycogen_phosphorylase_DUF3417"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11897">
        <property type="entry name" value="DUF3417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02094">
        <property type="entry name" value="more_P_ylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3417" evidence="11">
        <location>
            <begin position="14"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM48491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="718" mass="81239" checksum="7E27B080799F13E4" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6C9</accession>
    <name>A0A1W1I6C9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyanate hydratase</fullName>
            <shortName evidence="3">Cyanase</shortName>
            <ecNumber evidence="3">4.2.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cyanate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Cyanate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">cynS</name>
        <name evidence="5" type="ORF">NSJP_2406</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cyanate + 3 H(+) + hydrogencarbonate = 2 CO2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:11120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29195"/>
            <dbReference type="EC" id="4.2.1.104"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyanase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.104" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2406"/>
    <dbReference type="EnsemblBacteria" id="SLM48578">
        <property type="protein sequence ID" value="SLM48578"/>
        <property type="gene ID" value="NSJP_2406"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2406"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009439">
        <property type="term" value="P:cyanate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00535">
        <property type="entry name" value="Cyanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="PTHR34186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001263">
        <property type="entry name" value="Cyanate_hydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="SSF55234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00673">
        <property type="entry name" value="cynS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanate_lyase" evidence="4">
        <location>
            <begin position="73"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="146" mass="16205" checksum="F16AAE2283E4FF36" modified="2017-06-07" version="1">MDKESVRKAIKARRLAKKLTIADIAKDIGRNPTFVAAVLQGNHKLPADEGKKVGELLGLDADLTASLSKFPVRTDFPNSSDPFKYRLMEIIGVYGDSMREQANEMFGDGIMSAIDFTLDMEKVTGSQGEARCKITLNGKWLEYKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6F9</accession>
    <name>A0A1W1I6F9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48580">
        <property type="protein sequence ID" value="SLM48580"/>
        <property type="gene ID" value="NSJP_2408"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2408"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="76" mass="8517" checksum="BAC795AC5AE6D7E6" modified="2017-06-07" version="1">MSIIREDRVEATICETRLKDILREKGPQTLDALCAMPDFGWAQALLAVDHLSRSHEIVLKLIAPREYQVSLAGEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6H0</accession>
    <name>A0A1W1I6H0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48606">
        <property type="protein sequence ID" value="SLM48606"/>
        <property type="gene ID" value="NSJP_2434"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2434"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="132" mass="14607" checksum="446CC85B95071A86" modified="2017-06-07" version="1">MADAFSIRDPMIVEVESNENCETSFFARFKETGPARPIVHVRLFERNPAGEWYDVTGWSEHPALPACQAFAQPIEDSGAGLAYLVYGGIYGLRFKAAGSAEPWSLASPHQWGEAYLSLASDRDLRYAVPPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6N6</accession>
    <name>A0A1W1I6N6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative chromosome segregation and condensation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">scpB</name>
        <name evidence="5" type="ORF">NSJP_2482</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2482"/>
    <dbReference type="EnsemblBacteria" id="SLM48654">
        <property type="protein sequence ID" value="SLM48654"/>
        <property type="gene ID" value="NSJP_2482"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2482"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01804">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="233"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="290" mass="31342" checksum="7D2D9C24809741C5" modified="2017-06-07" version="1">MSETELQESGNMERPEAAASEQTGPSTEEAVVAPDAVAAHASDQMELTAILEALLFVSGEPMPLARLATTIGTVSKAEVQQALNNLREQLAHDGRGIQLVQVAGGYRLATKADCAPWLKRLEKAKTAQRLSRSALESLAIIAYKQPLVRAEVEEIRGVETSGVIRTLLERKLVRIVGRKEVPGRPIMYGTTKYFLEHFGLQDLSQLPPLREFKELGEAEQAMLPIEDVTIVGEQQAEPADSESPSESLAESSSDSPSDSMEPAPFQSEEGEMAMVAGSDHTFAGESVDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6P4</accession>
    <name>A0A1W1I6P4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48670">
        <property type="protein sequence ID" value="SLM48670"/>
        <property type="gene ID" value="NSJP_2498"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2498"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="299" mass="32116" checksum="A606891E46CA3EF2" modified="2017-06-07" version="1">MAGLILCVALLFSGLHETATSAVQESAAQGIGYVEKIVGELKEIRIERDGQPLTPALLLPLQTGDRVTALAPGSELYAQVGNRRVVVTVRNSPYHIPAVDAPPGFITRLRSTLVSMGAKLTTQYVRSSSPVSTSSRGREGPLSLPLIEDGTSRISSNRTMLALAWDGGTPPFQVQILGPGGQPLAAADRDEWRVRLVLPAGGVPPGAIHITVQDRTGDTVRRSIEVVSPESVPAASPALSHQDLPPDLQQVMAADALIQTHRKRWAFEAYQNIAPLADSYEPARLLRDCLEMVPSCYHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6T3</accession>
    <name>A0A1W1I6T3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2537"/>
    <dbReference type="EnsemblBacteria" id="SLM48704">
        <property type="protein sequence ID" value="SLM48704"/>
        <property type="gene ID" value="NSJP_2537"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2537"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="65"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="140" mass="15751" checksum="BA16CB23E6FC5CB1" modified="2017-06-07" version="1">MASEMPCLRQSSWTPVPAWASLSTAMICSSVCRFRVMAPSCGAHLSTGALPCQWSNFREEGHIQPGKPDQNAFIERFNRTYRTEVLNAYVFESLEQVQEISAEWLQSYNDERPHDALAGLPPAMYRAQLERGSSPLIVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6X2</accession>
    <name>A0A1W1I6X2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional deaminase-reductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2583"/>
    <dbReference type="EnsemblBacteria" id="SLM48750">
        <property type="protein sequence ID" value="SLM48750"/>
        <property type="gene ID" value="NSJP_2583"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2583"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="13"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="192" mass="20973" checksum="FF621DAC93AF2F3D" modified="2017-06-07" version="1">MDEARLSVPECSVFVGVSLDGFIARTNGDLDWLMGEGGGDSAEFGYNEFIAGIDAVVMGRGTFEKVLTFDKWYYGNKRVVVLSHRTLDLSVAQARGAVVDLMAGAPVEIVSRLTASGFRRLYVDGGLTIQQFLRAGLIQRLIISRLPVLIGRGIPLFGSLEHDVRLRHLATHTYAGGMVQSEYRIDPGELTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Z6</accession>
    <name>A0A1W1I6Z6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48639">
        <property type="protein sequence ID" value="SLM48639"/>
        <property type="gene ID" value="NSJP_2467"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2467"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="301" mass="33086" checksum="960FD2E1A9B6EF70" modified="2017-06-07" version="1">MLFTWLWLAVRSLVESQFRVMDPVPVSYRRTGSRGARIFGLGSMMLAAVALLMAGLPFQAEAGERSLPNSSKLRKTVAAGFGVQNAQSSVITVRTYDAESGEILSDESYELDIKDDRSPAMPQPRERIVAGGVGIGADGLSEFMLRVYDAADGKFLWEGRLNLNVTASAGEAVPVAVAVRPQATVTRVVEKTDPAGQPFFLLRVLDRDTGRLMWFDQFSTEGARVRAERIGVFGPNPGPIDIQDVDFRIRMFDENGRQLLWEDRIAETEDGSPSSELAQDQAGVIPQWFVGPSDSTNREEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I702</accession>
    <name>A0A1W1I702_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48755">
        <property type="protein sequence ID" value="SLM48755"/>
        <property type="gene ID" value="NSJP_2588"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2588"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012777292" evidence="1">
        <location>
            <begin position="20"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="154" mass="17428" checksum="599160E6FE51ABFB" modified="2017-06-07" version="1">MRACLLFLVLTMTAGCAFFDRDDDPSPVQDSIPEAVLTASCTELWKHYSDELRLVDDDDANWQMHDDKAQQYFGHFGAACNAADMRDAAAKDLRCKALWGLYVKEVGRMTKEEQTWLDHDAQQTEAMNRIRSSCAKTACTFLPGIKCRMPNNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I719</accession>
    <name>A0A1W1I719_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PP2C-family Ser/Thr protein phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pph</name>
        <name evidence="2" type="ORF">NSJP_2640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2640"/>
    <dbReference type="EnsemblBacteria" id="SLM48807">
        <property type="protein sequence ID" value="SLM48807"/>
        <property type="gene ID" value="NSJP_2640"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2640"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="276" mass="29890" checksum="3E4F39AD9FA07241" modified="2017-06-07" version="1">MGKPMPMRTLHSVRSDVGLKRTHNEDRFLADPAIGVYAVCDGMGGGNAGEVASALAVETIHAHLRTGRQDDRVSMGSDANLSPNTHRLAGAIRAANESIHEASWTNPSYAGMGTTIVAVHLSNDLLSIAHVGDSRLYLIRNGKIDALTADHSWVAEQVRRGLMTEGEAERSSKRNIVTRALGVERVVDVELGEIPVRHGDRFLLCSDGLTRGVRTPDILRAVEAASDVEDSADRLLAMANDAGGDDNTTVLLLSLFDEASSPFWRRLTQRWFPMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I728</accession>
    <name>A0A1W1I728_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7,8-dihydroneopterin aldolase</fullName>
            <ecNumber evidence="1">4.1.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHNA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2643"/>
    <dbReference type="EnsemblBacteria" id="SLM48810">
        <property type="protein sequence ID" value="SLM48810"/>
        <property type="gene ID" value="NSJP_2643"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2643"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015985">
        <property type="entry name" value="TehB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="PTHR42844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03848">
        <property type="entry name" value="TehB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00525">
        <property type="entry name" value="folB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FolB" evidence="2">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="316" mass="35825" checksum="6CB8A11114462578" modified="2017-06-07" version="1">MVGKIVIERLEFQGRCGVTREERHRPQPLALDLELDCDMSSAAASEKLADTVDYAKVLERVEALGHTEDCALLERLAERILAVLFEEFPIERVRLWLRKLAPPVAQTTASVGLRIDRIRPAYLIGSQPLTPSRFLLQNIHRVPKGRVLDVACGKGRHALYLANLGFDVEAIDRDAEAVFDLASTAKQRNLPNLTVQTVDLERATDDRPEFPANRYDAIVVCFYLHRPLFSWLVDALKPNGVLLYETFTIDNYRRHRHPRRWEFCLAHNELLRLTSALQVLSYDEGEHATNSGVDTVFTAQLLARKAALPEPDREPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7C4</accession>
    <name>A0A1W1I7C4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2602"/>
    <dbReference type="EnsemblBacteria" id="SLM48769">
        <property type="protein sequence ID" value="SLM48769"/>
        <property type="gene ID" value="NSJP_2602"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2602"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011473">
        <property type="entry name" value="DUF1579"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07617">
        <property type="entry name" value="DUF1579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013117007" evidence="1">
        <location>
            <begin position="23"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="200" mass="22412" checksum="62692B97896F05F7" modified="2017-06-07" version="1">MRVRFIPVACLSLIVMAAPVLAKEKKHDKQMDPQQMMELWKQMAQPGEPHKLFAGLAGSWTTVTKEWMEPGKPPTESSGTAEMKMLLDGRFLYQEYTGQMMGQPFSGIGIDSYDNMTKKYVTAWMDSMGTGIFLMEGTASPDGKTITLKGQHPEPGGGQMKHRAVWKIVDSNTQTFEMYGTHHGKKESKVLEITYTRKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7V6</accession>
    <name>A0A1W1I7V6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2772"/>
    <dbReference type="EnsemblBacteria" id="SLM48939">
        <property type="protein sequence ID" value="SLM48939"/>
        <property type="gene ID" value="NSJP_2772"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2772"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="24"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="208" mass="23258" checksum="E7B75A0382B80E06" modified="2017-06-07" version="1">MQLGILIRSRLVKGGFMAVESIMLPLGTPAPDFRLQDVASGRWWTLESFEGKDALLIMFICRHCPYVQHVERELARIGHDYRDRSLGILAVSSNDSNRYPDDAPPRLREMADRLGFTFPFCFDETQDTAKAYKAVCTPDFCLFDRDRRLSYRGQLDDSRPGNGRQVDGGDLRAAIEAVLSGRPVAGSQKPSIGCSIKWKPGNEPTGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7X6</accession>
    <name>A0A1W1I7X6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48959">
        <property type="protein sequence ID" value="SLM48959"/>
        <property type="gene ID" value="NSJP_2792"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2792"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="162" mass="17876" checksum="EC28A33328928200" modified="2017-06-07" version="1">MTRRATAAKTSAGILLYRNRPGGIQVFLAHPGGPFWARKDDGAWSIPKGEYDPAEDPLAAARREFTEETGLALQGPFEALGQLKQPGGKVITAYAVEGDVDAVSVVSNTFELEWPPRSGKMCRFPEVDRAAWFEFETACRKVLPGQRPFLDRLMKSMMGESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Z7</accession>
    <name>A0A1W1I7Z7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">recX</name>
        <name evidence="5" type="ORF">NSJP_2957</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Modulates RecA activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RecX family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2957"/>
    <dbReference type="EnsemblBacteria" id="SLM49124">
        <property type="protein sequence ID" value="SLM49124"/>
        <property type="gene ID" value="NSJP_2957"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2957"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01114">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="175" mass="19965" checksum="8A05D99E9B78D785" modified="2017-06-07" version="1">MPRRIEQAGISKTARAKQAVPDDSWLKAAVRYLARFDRTAKQVEEFLRARGASPVQAARTLRRLEALRYLDDSAYAERWIASRLTRGPCGAARLRDELLRKGVSENVTDGALGRALAEVDQDTLARRAVGLKQRRGGTLSRWQTLRLLRQRGFEEDVISRIMGEWQETERVDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I800</accession>
    <name>A0A1W1I800_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein SyrD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2985"/>
    <dbReference type="EnsemblBacteria" id="SLM49152">
        <property type="protein sequence ID" value="SLM49152"/>
        <property type="gene ID" value="NSJP_2985"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2985"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005898">
        <property type="entry name" value="Cyc_pep_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43553:SF11">
        <property type="entry name" value="PTHR43553:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="142" mass="16266" checksum="25513CBD4D1F7056" modified="2017-06-07" version="1">MVFSDFYLFDKLLGLDESSIESQAHSYLARLQIDHKVTINGRAFSTTELSQGQRKRLALVTAYLENRTIYVFDEWAADQDPEYKEVFYRQLLPDLRARGKSVIVITHDDRYFHLGDRVVKLEEGRIVDADAAGLRARPAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I810</accession>
    <name>A0A1W1I810_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ALGX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_2980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; alginate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2980"/>
    <dbReference type="EnsemblBacteria" id="SLM49147">
        <property type="protein sequence ID" value="SLM49147"/>
        <property type="gene ID" value="NSJP_2980"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2980"/>
    <dbReference type="UniPathway" id="UPA00286"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031811">
        <property type="entry name" value="ALGX/ALGJ_SGNH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16822">
        <property type="entry name" value="ALGX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0016">Alginate biosynthesis</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="ALGX" evidence="5">
        <location>
            <begin position="132"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="402" mass="45821" checksum="BE11C0F40AA23F33" modified="2017-06-07" version="1">MPFAILKHARLLLLGAILVVFFLPLILLIVFAAFHKSSASDLGSDRLELSGVVKARPEPAVSFSNWLDHTLQGHFDDQFSKVYGGRALFVRLGNQIYYSLFDKSYMQDQSIIVGKHHQLYERWYIEDYCKIRRPMRRETVAARARQIRELQSELQNRGIPLIVLITPNKASIYPEDIPEGFCGFPKFSFRDYDSFMSEFAAQHIQYVDGRAVTLAARAAAAVPLFCQGGTHWNGLGAYYTARQLTERIGKLTQTSVGPLFLQRLTVDHSPREIDRDLAALLNLAVPPYDYPAPHVMVEQRPAAGQLGKAVFVGGSFNWTLLDLLNKAKVFREIDFYYYYKLALETFPVRTSKPVDRATIDWQKDVLNARVLILEINESNFHSEYITAFLADLLQFFRKSPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I878</accession>
    <name>A0A1W1I878_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49206">
        <property type="protein sequence ID" value="SLM49206"/>
        <property type="gene ID" value="NSJP_3039"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3039"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012144916" evidence="1">
        <location>
            <begin position="24"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="336" mass="36452" checksum="16746750FBC6758C" modified="2017-06-07" version="1">MRWKIVSIVGLALAAATVDAAYADDSRQCWLESIQATFAAETSTYRVEAGCMYYHPLEGPVPAQRLPAHWSSQGSYDSRTGLAREDVMIESGTVTTTLFCPSDPWLGSSLQPGMVRCTKPTFETRKAPVKWWLTYLHEGFYSRTNEKIGPLPNSTGFPYDRAALIAQRDAALKAEAAAAAAALQQQNQRLKQAKQPGPALIAPIILSPMTNALFISGTNVPIKLAPPREWVDTQVGLDGKPMNNNRLYMVRLERKDAAGNWVPHTTLPVGAVQAESPTGFTGFGSGAPPGGVSTPGAWRLSAQMSSPTATRWSDWVEFAVTSPNKAIQKTPKMFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8A5</accession>
    <name>A0A1W1I8A5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Multi-domain non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_2984</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2984"/>
    <dbReference type="EnsemblBacteria" id="SLM49151">
        <property type="protein sequence ID" value="SLM49151"/>
        <property type="gene ID" value="NSJP_2984"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2984"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="601"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1676"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2733"/>
            <end position="2808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3106"/>
            <end position="3159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3177"/>
            <end position="3199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3279"/>
            <end position="3311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3394"/>
            <end position="3415"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="638"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="1711"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="2768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="3428" mass="379174" checksum="25DF6BF1681FBAA3" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8N4</accession>
    <name>A0A1W1I8N4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 4'-phosphopantetheinyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2986"/>
    <dbReference type="EnsemblBacteria" id="SLM49153">
        <property type="protein sequence ID" value="SLM49153"/>
        <property type="gene ID" value="NSJP_2986"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2986"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ACPS" evidence="3">
        <location>
            <begin position="140"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="258" mass="28596" checksum="34D24654CD554428" modified="2017-06-07" version="1">MNGYQPVPFPAIPLTSPSRLLDMLGGSLELEDGAIHVWQCSLDEADPCHDRLSAYLDAEERSRASRFVHERDRRRFVLAHGCLRVLLARYAGPSPAALSFGRSREGKPVLAREAGPAAIAFNLSHSHGRMLLAVSRHREVGADLELMREDVEALKLAERFYTRNEYAALTAQPSAQHTLCFFQYWVAKEAVLKGQGKGIPSLGECEIDLGSQERQIEVRILPGSNMDKGWYVQWLSCGLGWSAAVAFYGTAVLRGMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8R4</accession>
    <name>A0A1W1I8R4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhgF</name>
        <name evidence="3" type="ORF">NSJP_3271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3271"/>
    <dbReference type="EnsemblBacteria" id="SLM49438">
        <property type="protein sequence ID" value="SLM49438"/>
        <property type="gene ID" value="NSJP_3271"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3271"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
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    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="697"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="820" mass="88576" checksum="CDD7A21E6907EB2A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8X4</accession>
    <name>A0A1W1I8X4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49467">
        <property type="protein sequence ID" value="SLM49467"/>
        <property type="gene ID" value="NSJP_3300"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3300"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13840">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031877">
        <property type="entry name" value="SmbP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16785">
        <property type="entry name" value="SMBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013252487" evidence="2">
        <location>
            <begin position="27"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="228" mass="24336" checksum="F2791F71A88B9406" modified="2017-06-07" version="1">MLRRGVLILCGSLVLFLGLAPCSSNAQTAATPPPPPIADQPQMVPSDRPETATTADRASYDRQLSEAVAHARKAEVAGNEGNIPEMLRHTNMSLEQAKAAQVAGANPDLDDGIANLKETIMVGKRDQIAPSSIKEARVKLVQASAVHPVSTAGTKSSRILTGELRRTTTISTFPEQEAYVVRDPQTGADTPVFMSPEMSRQVKEGDMVQTQIDSQGRVVAISPKSPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I907</accession>
    <name>A0A1W1I907_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49411">
        <property type="protein sequence ID" value="SLM49411"/>
        <property type="gene ID" value="NSJP_3244"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3244"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012122237" evidence="1">
        <location>
            <begin position="23"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="390" mass="42683" checksum="746C797644DCF201" modified="2017-06-07" version="1">MVPFRFLVSALALMLAGPSVVAAEQYALLNYESKPDQPVRREGIAIMNIEPDSSDFGKILMEIPLPSDLVAHHIFFNRDKSKAYITALGKSILHVVDLTKFPYQLRAIAVPDCQMGEDLVVSEDNKTWFLTCMGSSNVIMGDAVKDQPVKTISAAGSDAFILYPHGIAIHNGIDRILITSTVKPDLSEAGDTVTVIEASTGTVLSTHRVTSKPAPAKTAPVEVMFAPNANPPVVHITNMLEGTLWAGVWDPKTKTFSFNQIDDFGPREQGMPLEMMYNKKGDRLFVTTAKPGFVNLYDNSDPKHPKFLKAIATAGGAHHTVLSPDERYLFVQNSFLNLEGMSDGSITVIDLKNDQVVGSIDTLKSAGFNPNCIMPLPNHFQKPTMRAMMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I908</accession>
    <name>A0A1W1I908_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49480">
        <property type="protein sequence ID" value="SLM49480"/>
        <property type="gene ID" value="NSJP_3313"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3313"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011963833" evidence="1">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="115" mass="12686" checksum="2F0C75581B4097D3" modified="2017-06-07" version="1">MMVLPLGILVSLALAFAVGACSVPSAQGQMMIESSYLGSSSGEKATGTGHFGKNPADMTSFEVTTDYFTRRSEEEDRERADREKRMRAMSNYGNMTQGGESYFDRLYYQPMVGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I933</accession>
    <name>A0A1W1I933_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sialidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3146"/>
    <dbReference type="EnsemblBacteria" id="SLM49313">
        <property type="protein sequence ID" value="SLM49313"/>
        <property type="gene ID" value="NSJP_3146"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3146"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sialidase" evidence="1">
        <location>
            <begin position="228"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="430" mass="47097" checksum="A48DB317882F032F" modified="2017-06-07" version="1">MNRPHRSRQYYGRGPMRYHVIPLCLIVLCWSGLRSWDSLAGMPESEMASGAKRTLVEGTYQLSPPAIQFDKDGTLHAAWLEQRGDARSVKTMRVSQDLHQEAVQVNPKEAEPNALHQAPGLAVGQDGRIFVSWSTAKASDAPFASDLRLARSVDGGRTFEPPILVNDDKQPIGHGFESVLVDRQGGVNIAWLDNRHKSKSGAGAVFGGSHDGGKGVETNVAIDDMACPCCRPMLTQAPDGSIWVAWRKTFEGNVRDIVVARSIDQGRSFSAPIRVHEDKWVFPACPHRGPSIGFDGAGRLYVAWYTEGTDEHPQVFLSVSDDQGQTFATPVSLHASTTSLPDQLRMAVAPTGAVVAVWEELTGVRKRIVMRVSLDRGRTFGSLQTLSTGANAEFPTVAIHESGQVALSWNEHVWPNNRIVVLLERLSDHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I960</accession>
    <name>A0A1W1I960_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">lipA</name>
        <name evidence="8" type="ORF">NSJP_3401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3401"/>
    <dbReference type="EnsemblBacteria" id="SLM49568">
        <property type="protein sequence ID" value="SLM49568"/>
        <property type="gene ID" value="NSJP_3401"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3401"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="48"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="287" mass="32159" checksum="E672C1CAD2C2B63C" modified="2017-06-07" version="1">MSRPRLPAWFRVQAQTGPDYLYIKRVLEELKLHTICEEARCPNRWECWNARTATFLILGDICTRRCHYCSVQTGKPLPLDLKEPGRVAEAVRALGLRHVVVTSVNRDELSDGGAGMFAATIRETRRLNPDCTIEVLIPDFGGDAAALNEVCCARPDILNHNIETVARLFPAIRPQGKYGRSIEVLRQAKQQGMTTKSGLIVGMGETLDEARQVMRDLRSGECDILTIGQYLQPTKQHIPVERFYEPALFDALKTEALALGFHHVESGPLVRSSYHASDHAGLDRNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I981</accession>
    <name>A0A1W1I981_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RCK C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3389"/>
    <dbReference type="EnsemblBacteria" id="SLM49556">
        <property type="protein sequence ID" value="SLM49556"/>
        <property type="gene ID" value="NSJP_3389"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3389"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK C-terminal" evidence="1">
        <location>
            <begin position="120"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="216" mass="24149" checksum="9E4E24DC7A060FBD" modified="2017-06-07" version="1">MMSLEFIGRLQKELSLTGSAVYESVVAVAERVNRKVHILRLHSQAAQLLSQIERAHGELGHRIADVVSDKVSTGRGSLSIAPDELQRTLDQSLGRVRDLKQALHQVDGQIRELKMETIHEDLLTLQRDLSLHSAALERMPVVRRAPAIGKHPTDLMIPESVRFITVFRGPFLIPPSDSLVFQPDDVVVIMGTRSDLDQVAALFGTPRKVKPIYREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I983</accession>
    <name>A0A1W1I983_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3375"/>
    <dbReference type="EnsemblBacteria" id="SLM49542">
        <property type="protein sequence ID" value="SLM49542"/>
        <property type="gene ID" value="NSJP_3375"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3375"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="732" mass="79724" checksum="7746D1DC42623940" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9D8</accession>
    <name>A0A1W1I9D8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49541">
        <property type="protein sequence ID" value="SLM49541"/>
        <property type="gene ID" value="NSJP_3374"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3374"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="233" mass="26467" checksum="F4025F0584388551" modified="2017-06-07" version="1">MGICRFSLRRLLVAPLTCLCLSGCTIPQTPYRTVYEDPVNYVRLELDDTVLPEWSPGHHSHPRTFTSEEIVAILTGMKVQEHRIWLQKWIQGEAPLVPAFRDEEVTILAPQIAEAFAAAAYNERITFYLSEPQTSAKRLITTGGLYVRDSEIHVLLGNWQIVYGIPLYGMIYDRRYPMRPTVAKGFDLFFQPADAVIIQNSSFLDILFANNKDELVINIDRLPAAMVMAPPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9G4</accession>
    <name>A0A1W1I9G4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49630">
        <property type="protein sequence ID" value="SLM49630"/>
        <property type="gene ID" value="NSJP_3463"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3463"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="128" mass="13481" checksum="61EBE0E1F8A244F2" modified="2017-06-07" version="1">MSLGRSRKVGVRNVDTHLVPEVPNHLREACACDAGQKGEDVAAGSAAEAMKNLPGGTDSEGGSLFLMKGTQPFQILTASDQAHVLPDNLRDVDPVPDLIDDVFRNQASAHGSRGSSFPPQAGGSFERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9L2</accession>
    <name>A0A1W1I9L2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 2">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hpt</name>
        <name evidence="4" type="ORF">NSJP_3571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3571"/>
    <dbReference type="EnsemblBacteria" id="SLM49738">
        <property type="protein sequence ID" value="SLM49738"/>
        <property type="gene ID" value="NSJP_3571"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3571"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="12"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="179" mass="20245" checksum="EF4B19A41505FB1E" modified="2017-06-07" version="1">MERIFGRPIVTQEEMRARIKELGKQITADYAGKDFVLVGVLKGAYAFYADLARAIRIPMRVDFLVVTSYGSRAKTSGKVKIVTELTEDIKGKEVLLVEDIVDSGLTAQYLIKTLAKKKPQSIKVCTLLSKPERRTVDVALEYVGFKIPNRYVVGYGLDYQQKYRNLPYLAVLDMEGEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9P4</accession>
    <name>A0A1W1I9P4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">metE</name>
        <name evidence="13" type="ORF">NSJP_3543</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21196"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58140"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
            <dbReference type="EC" id="2.1.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3543"/>
    <dbReference type="EnsemblBacteria" id="SLM49710">
        <property type="protein sequence ID" value="SLM49710"/>
        <property type="gene ID" value="NSJP_3543"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3543"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Meth_synt_1" evidence="12">
        <location>
            <begin position="7"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Meth_synt_2" evidence="11">
        <location>
            <begin position="438"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-methyltetrahydropteroyltri-L-glutamate binding" evidence="10">
        <location>
            <begin position="18"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-homocysteine binding" evidence="10">
        <location>
            <begin position="443"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-methionine binding" evidence="10">
        <location>
            <begin position="443"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-methyltetrahydropteroyltri-L-glutamate binding" evidence="10">
        <location>
            <begin position="527"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="611"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="617"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="655"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="677"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="738"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM49710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="772" mass="85734" checksum="DB9D254DA79FB8EA" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9S1</accession>
    <name>A0A1W1I9S1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine_BP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3597"/>
    <dbReference type="EnsemblBacteria" id="SLM49764">
        <property type="protein sequence ID" value="SLM49764"/>
        <property type="gene ID" value="NSJP_3597"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3597"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00106">
        <property type="entry name" value="TIGR00106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="102" mass="11642" checksum="6565B0A7857A22DB" modified="2017-06-07" version="1">MVLLEFSMSPLGKSESVGKYVARSLDIVDKSGVDYRLNPMGTVLEGDWDEVMAVVKKCYERMKKDCNRISCSVKIDFRKGHSGRLSGKVKSVERRLKRRVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9W9</accession>
    <name>A0A1W1I9W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase, beta-lactamase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3680"/>
    <dbReference type="EnsemblBacteria" id="SLM49847">
        <property type="protein sequence ID" value="SLM49847"/>
        <property type="gene ID" value="NSJP_3680"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3680"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="356" mass="38928" checksum="D3C343A52EFAC8AD" modified="2017-06-07" version="1">MDARLAQVLQAYIEPPACRVRDVAVSFAYRNGTDKELHAGILRQAGQSASHSIHVDSRYSVQSITKSLTAAAVLRLVHSGLLTLDSPLARWLPDVPHAARITLRQCLQHTSGLPDYGAVPEYHQAVNAQAAPWSFAEFLERTHAERLLFEPGQGWRYSNIGYMVVRRLVETVCGESFAEIISKKVCQPLGLQHTFVIGDREGFQALVPAYSVSMSPDGLPVDVRSRYDPGWVATGVVASTASDLVRFFDKLLAGDLLPGVLLEEMRRVVHVGTPSSQRWVMPSYGLGLMADPQSPYGILYGHNGGGPGYTSTALHVLTPAGQSVTVAVLSNTENFYEVELMAFTLIDQLTRGRLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9X4</accession>
    <name>A0A1W1I9X4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mrp</name>
        <name evidence="4" type="ORF">NSJP_3406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3406"/>
    <dbReference type="EnsemblBacteria" id="SLM49573">
        <property type="protein sequence ID" value="SLM49573"/>
        <property type="gene ID" value="NSJP_3406"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3406"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="291" mass="30911" checksum="8495B9AC7D1D6261" modified="2017-06-07" version="1">MADEHTHQAQSTQAKDTLISGVKHVIAVSSGKGGVGKSTVASNLACALALSGAKVGLLDADLYGPNIPMMMGSTAGPEQKDGKILPVESYGVKLISMAFLVPEEAPLVWRGPMVHQYLQAFFRDVLWGDLDYLLIDLPPGTGDVQLSLSQMVPLAGAVTVTTPQEVALYDVRKGMAMFQKVNVPLLGIIENMSFFVCGHCGERTEIFSHGGGERAAEKLGVPFLGRIPIDPAIRDGGDSGHPIVVAHPESPQAAAFRDIAQKLMNRLGGSEKEGASIDSLLKKIKEPFGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Z1</accession>
    <name>A0A1W1I9Z1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3638"/>
    <dbReference type="EnsemblBacteria" id="SLM49805">
        <property type="protein sequence ID" value="SLM49805"/>
        <property type="gene ID" value="NSJP_3638"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3638"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="48"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="240" mass="27743" checksum="C837474A7DDFE5CE" modified="2017-06-07" version="1">MKVLNLGCGTKTSPKAINIDWSIYLTIKSNYFFRLCSPIVLGEDRRNKLRGLDRSILVHDIRKGLPFHDRSVDAVYHSHMFEHIDRSKAPVFLQEVKRVLVSGGIHRIVVPDLEYLARAYLQHVAQVKDDPSSACDHERYVSEMIEQMVRREAYGTRHQPFLRRALENLLLGDARARGETHQWMYDQCNLAHLLRENGFGNIRVRSFNNSAIPDWQSFGLEVKEDGSEYKPQSLYMEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA43</accession>
    <name>A0A1W1IA43_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA methylation and regulatory protein Ada</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3698"/>
    <dbReference type="EnsemblBacteria" id="SLM49865">
        <property type="protein sequence ID" value="SLM49865"/>
        <property type="gene ID" value="NSJP_3698"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3698"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010316">
        <property type="entry name" value="AlkA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037046">
        <property type="entry name" value="AlkA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06029">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01009">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="136"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="537" mass="60777" checksum="51268864BCCBE676" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA49</accession>
    <name>A0A1W1IA49_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">pyrH</name>
        <name evidence="8" type="ORF">NSJP_3592</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Allosterically activated by GTP. Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3592"/>
    <dbReference type="EnsemblBacteria" id="SLM49759">
        <property type="protein sequence ID" value="SLM49759"/>
        <property type="gene ID" value="NSJP_3592"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3592"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
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    <sequence length="241" mass="25878" checksum="A196937D345B3090" modified="2017-06-07" version="1">MTSTNYRRILLKVSGEMLAGEQGYGIQPSVLEGLASEIASVVALDIEVAVVIGGGNIFRGIAASASGMERASADYMGMLATVLNALALQNALERAGVMTRVQSAIEMRQLAEGYIRRRAIRHLEKKRVVIFAGGTGNPYFSTDTAAALRAMEIGAQVIMKGTKVDGIYDADPVKNPNAKKYQEISFLAILNQNLKVMDATAISLCMDNSLPLIVFSLKQQGNFKRVATGEPLGTLVTAERH</sequence>
</entry>
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                <person name="Dimitrov K.M."/>
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                <person name="Swayne D.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <proteinExistence type="predicted"/>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
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            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
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    </evidence>
    <sequence length="891" mass="100463" checksum="A462EEDBD6639279" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAJ9</accession>
    <name>A0A1W1IAJ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50020">
        <property type="protein sequence ID" value="SLM50020"/>
        <property type="gene ID" value="NSJP_3853"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3853"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="56" mass="6079" checksum="BF45106C03865BBC" modified="2017-06-07" version="1">MADVQIEDGIIRIVGLDVQDPKAAAVLAEYPQVRWAEITRRALKIGLGYLKGGGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAK7</accession>
    <name>A0A1W1IAK7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FecR, iron siderophore sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3920"/>
    <dbReference type="EnsemblBacteria" id="SLM50087">
        <property type="protein sequence ID" value="SLM50087"/>
        <property type="gene ID" value="NSJP_3920"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3920"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032623">
        <property type="entry name" value="FecR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16220">
        <property type="entry name" value="DUF4880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4880" evidence="3">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="132"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="342" mass="37256" checksum="60E602415DC50BC9" modified="2017-06-07" version="1">MSGPDPTGDEQERLETEAVTWIVRLTSGDATEADHDAVNAWRRLSPDHEEAFLKVERLWIGLEGLRSHVAEPSAEFLSTKSAPASSTVASAGRGRRATARPRVAWCAIAATLSAIAITVVLQSGFFARFSADYRTGTGDQETARLADGSLLQLNTQAAVAIRFTDSTRRVDVLEGEADFQVAKDISRPFVVTTDDGNVRAVGTEFMVRKMPDTTVVTVIEGIVEIRALPGRSGGDEPVRLEAGQRLQFGPALGVGPVQRVDTHLATAWQRNKLIFEGTPLATVVDEINRYRPGHIMLLSPSLSNHRVSGVFDLDRLDSAVAAIERTLPVTTVHMTNRYVFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAT4</accession>
    <name>A0A1W1IAT4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50124">
        <property type="protein sequence ID" value="SLM50124"/>
        <property type="gene ID" value="NSJP_3957"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3957"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="68" mass="7319" checksum="A459C8A607DEA043" modified="2017-06-07" version="1">MHGNRQSKLAVCGCGKLHVTYGSITMHFDKDEFQVFADSIGRLASILKQSSVGSMPAHKGSSSAHMCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAT6</accession>
    <name>A0A1W1IAT6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative FecR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3945"/>
    <dbReference type="EnsemblBacteria" id="SLM50112">
        <property type="protein sequence ID" value="SLM50112"/>
        <property type="gene ID" value="NSJP_3945"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3945"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032623">
        <property type="entry name" value="FecR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16220">
        <property type="entry name" value="DUF4880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4880" evidence="3">
        <location>
            <begin position="8"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="119"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="326" mass="36414" checksum="53C17DB0DFCCDA31" modified="2017-06-07" version="1">MTEEQASRQALEWLLLLHDRPHDPVLHEQFDAWLTTSDENGQAWDDAQRLWGLIGETPPVHADLWRPKASPAVRSRPAVRRPGRWTRYWKPAVAMVGLAACLVLIFPSIRIYWEADHWTWIGETVQVTLRDGSTVHLSAGSAIRVNDETGVRRVDLLAGEAFFDVHPDPSRPFQVKAEEWTTTVLGTAFDVHLGSQTASVAVERGSVLVDRTGDDPPLEQRLEAGDWVRVERAMGVTAQGHGQPSQVAAWRQGRLIVKSRPIGEVIAELERYHRGVIVVTDSQLKSRLVSGVYDLTQPLEALRAAVQPHQAVVRQLTPYLVIVSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAV0</accession>
    <name>A0A1W1IAV0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3959"/>
    <dbReference type="EnsemblBacteria" id="SLM50126">
        <property type="protein sequence ID" value="SLM50126"/>
        <property type="gene ID" value="NSJP_3959"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3959"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="597" mass="66408" checksum="2C3E68A13BC2F713" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAV8</accession>
    <name>A0A1W1IAV8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TonB_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NSJP_3963</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3963"/>
    <dbReference type="EnsemblBacteria" id="SLM50130">
        <property type="protein sequence ID" value="SLM50130"/>
        <property type="gene ID" value="NSJP_3963"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3963"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="11">
        <location>
            <begin position="244"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="159"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM50130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="321" mass="35017" checksum="2D65B287932F7DCB" modified="2017-06-07" version="1">MTRFLRQGFPSSQQFDEVHSPLLSKSPLVLAPVPGFRVRETPRSRVGRTAKIGWSISGAFHGVVLIAAILFNLQITFSRPAPQQAPFHWDVSIMAAPSPQATIADGSKPQETPPSHEIYAEGAVQQQVMSSLESVVPQYEEQDSQADLSLGRAVEARAKFEPHSQRNDDVAKSMAAASTSESSAPPPDMISESESSTVQVQAEPVQAAVLHRPSAIVKNLVNRSIRPDYGWLMNTLRTRLEDVKTYPSPAKANHWQGRVVIQVSVEPDGRITNAEIQQSSGYPVLDFAALEALQATSPLQLAHGLDGRSVVMLVPINYQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB14</accession>
    <name>A0A1W1IB14_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative iron-regulated membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50089">
        <property type="protein sequence ID" value="SLM50089"/>
        <property type="gene ID" value="NSJP_3922"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3922"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005625">
        <property type="entry name" value="PepSY-ass_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34219">
        <property type="entry name" value="PTHR34219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03929">
        <property type="entry name" value="PepSY_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="416" mass="46447" checksum="87D2627D403715A3" modified="2017-06-07" version="1">MGVGFKYVIHMRILGVVIHRWAGLLTALFLFMSGLTGTVISWDHEIDEWLNTHLFDADTTGPAIPYLELAARIETADPRVRVSNVPLQTEPGRSLLFGVQPRVDHQTGKLYRLDYNQVFLDPGTGRELGRREWGAVAVDREHLMAFLYRLHYTLHIPNFAGQNRWGHWFMGGVALIWLFDCCVALAISFPDRQRWRKSFAIRLGSRYQLNFDLHRAGGLWTWGMLLVLAMSAVYLNLNREIVRPVVSTMTTVTPSPFDVRVQRPLNNPLEPTLDYAAAIARGQEEARLKGWTEPVGSISYNARYGIYQVRFFQPGNDHGSGGFGVRRIYIDGTDGAYLGELIPGTGTAGDMFLQLQFPLHSGRIAGVPGRIFISLMGLAVAGLSVTGIVIWLKRRGTLSALTTAPNNSSRNSLASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB83</accession>
    <name>A0A1W1IB83_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">carA</name>
        <name evidence="4" type="ORF">NSJP_3992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3992"/>
    <dbReference type="EnsemblBacteria" id="SLM50159">
        <property type="protein sequence ID" value="SLM50159"/>
        <property type="gene ID" value="NSJP_3992"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3992"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="391" mass="42206" checksum="EB7D635F91C60CF7" modified="2017-06-07" version="1">MSRALLALADGAVFEGQALGYEGDTAGEVVFNTAMTGYQEVLTDPSYKGQIITMTSPHIGNYGLTPDDVESRRIWAEGFVIKEGSVLSSNWRSRQQLHEYLQAAKVVAIEGLDTRALTRHLRQHGSQPGVITHGAASEAGAVEKAKHAPGIVGVDLAAAVTCARAYQWAHGSGEWAPSLDDRRARSSRRWKVVAYDFGVKQNILRRLVDVGCDVTVVPASTTAEDVEALKPDGIFLSNGPGDPEGVPYAIEAVRSLIGRRPIFGICLGHQILGLAMGLKTYKLKFGHHGANHPVMDLRTRKVEISSQNHNFAVQVSARQTAVSEPPPVVETVFGRVAVTHVSLNDQSVEGLACVEQPVFSVQYHPEASPGPHDSAYLFEDFVGVMEKSYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBA5</accession>
    <name>A0A1W1IBA5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50304">
        <property type="protein sequence ID" value="SLM50304"/>
        <property type="gene ID" value="NSJP_4137"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4137"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="295" mass="31885" checksum="B057F22BA8E35691" modified="2017-06-07" version="1">MARILATGGSGLIGRSLLARMSAHAEVVAVGRHEPEVSGVQWIAHDLSDSILPVLPKDVSTVIYLAQSDHFRDFPEQARNIFEVNVANVQRMLDWARVSGVQRFILASSGGVYGHGENSFREDDKVGPGGPLGFYLASKQCSELVAASYSECFSVVILRFFFVFGPGQKKSMLIPRLIDSIKEGRPVTLQGEEGIRLNPIFVEDASLAVSRALELSGSHIINVAGPEVMHMRDIASLIGKAVGRDPVFHVDHAASPRHLSGDITKMCRLLAAPTVSFSDGLERTLKGSHGGSHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBG7</accession>
    <name>A0A1W1IBG7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50113">
        <property type="protein sequence ID" value="SLM50113"/>
        <property type="gene ID" value="NSJP_3946"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3946"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="10"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="109"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="171" mass="19692" checksum="A28EF06C03674F1E" modified="2017-06-07" version="1">MNDEQQKLELYLTHRGELINYAAGILGCRAMAEDVVQEAYLRFDRPWDRSEIATPVGYLFRIVRNLAVDWSRRVALERRHVDLVEEPPAIAESRATPEEEVSHRQELALVMEALTELPERSRQALEMHRFGGLTLEEIGRRLRVSPALVHGLIHKALIHCQAKLRSSHLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBR9</accession>
    <name>A0A1W1IBR9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pleiotropic regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">degT</name>
        <name evidence="4" type="ORF">NSJP_4162</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4162"/>
    <dbReference type="EnsemblBacteria" id="SLM50329">
        <property type="protein sequence ID" value="SLM50329"/>
        <property type="gene ID" value="NSJP_4162"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4162"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="379" mass="41687" checksum="FC4F88517CA0E8A2" modified="2017-06-07" version="1">MGVPLLDLAAHHAPLQKEIMAVLEQVVRSQAFILGPEVAKLEERVASYCQAKAAIGVSSGTDALLISLMALGVGPGDEVVTTPYSFFATAGAVVRLGAKPVFVDIEPRSFNIHPDKIERAVTAKTKALIPVHLYGQSADMAPIMDLAGRRKLAVIEDAAQAIGTEYKDGRRAGSIGTVGCLSFFPSKNLGCLGDAGMVVTNDADLAERLRVLRVHGSKPKYYHKLIGGNFRIDTIQAAVLNVKLNYLDGWTKRRQENAQRYETLFRQTGLPERGAVTLPEAVYRASGKSHYHIYNQFVLRVERRDDLIAHLKQKGIGAEIYYPVPFHLQECFRYLGYKEGDFPESERAAKDTIAIPIYPELTAEQQAEVVEGIGSFYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IC23</accession>
    <name>A0A1W1IC23_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_4156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4156"/>
    <dbReference type="EnsemblBacteria" id="SLM50323">
        <property type="protein sequence ID" value="SLM50323"/>
        <property type="gene ID" value="NSJP_4156"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4156"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="235" mass="26294" checksum="5D1ED00BA757412B" modified="2017-06-07" version="1">MGIDFAQAEFLDLCAALGGIQNPVLGLGSLTIREPAEQIGQFARLYGYDSLEKEGSVRAFFRDRYNIRDYRDCDLNGRASLSLDLNRPVPADLVGHFGTILNGGTLEHVFDVRQAMENLHRLTRTGGTLIHMAPLTWYEHGFFNFNPLLFHSMIEANGYELLAEGYYALKDVFPDGPPRPQVFITRRAGEPTSMAKPMHELLAGSELPANMMYVVALRKEKDAPFVSPYQVHDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZP3</accession>
    <name>A0A1W1HZP3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5615 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46204">
        <property type="protein sequence ID" value="SLM46204"/>
        <property type="gene ID" value="NSJP_0032"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0032"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041049">
        <property type="entry name" value="DUF5615"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18480">
        <property type="entry name" value="DUF5615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5615" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="122" mass="13172" checksum="3FDCF6C527C148BF" modified="2017-06-07" version="1">MKLLLDTCISGTAVAPLKAAGHDVVWIGDLSADPGDEEILALAYRESRILITLDKDFGELAVVRDQAHAGIIRLVVVSSSQQATLCEIVLKRYGTELESGAIVTVEPGRIRVRPRLPRTGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZU3</accession>
    <name>A0A1W1HZU3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Nitrate oxidoreductase, gamma subunit</fullName>
            <ecNumber evidence="7">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_0106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.7.99.4" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0106"/>
    <dbReference type="EnsemblBacteria" id="SLM46278">
        <property type="protein sequence ID" value="SLM46278"/>
        <property type="gene ID" value="NSJP_0106"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0106"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019020">
        <property type="entry name" value="Cyt-c552/DMSO_Rdtase_haem-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09459">
        <property type="entry name" value="EB_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EB_dh" evidence="6">
        <location>
            <begin position="57"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="275" mass="30478" checksum="BC993D50FD9006A0" modified="2017-06-07" version="1">MGRMTTKTASRSLLALFSFILVVAGVLGGLGIPLVSSEGMVIRAHYAQGDLPSTPEDAAWAKISPMTLPLSGQIITRPVWPEPTARALTVRAVHNGTDLAFLLEWQDNTKNDRLTPGTFRDGVAIGLPLGDAPAFFCMGQLDHYINIWHWKADWQSDIDRRAARNTDKQREGVRTFEVIPRRVSSVEDLIGGGFSTLTTKEKQGRVQGKALWKDGVWHVVMRRPLVSEEQENEAKLIPGRVQTVSFAVWNGENKERNGQKAVAPWFQLSIDPANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZV5</accession>
    <name>A0A1W1HZV5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0118"/>
    <dbReference type="EnsemblBacteria" id="SLM46290">
        <property type="protein sequence ID" value="SLM46290"/>
        <property type="gene ID" value="NSJP_0118"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0118"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="36"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="121"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="243"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="278"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="320"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="359" mass="39842" checksum="8BB09DEF9F048F35" modified="2017-06-07" version="1">MTEQSPASTVTAPTSQTPHVDFLEYWTAGAREVKTFRGHSHGIWSVAFAPDALTLASAGVDRLVRIWDIETGRLLRSLRGHTNDIRAVAFTPDGQTLATGSEDRTIRLWNPKTGEPLKLLFTRYDHNVCSLSLSPDGLMLARGSHNKDIKIWEVTTGTELMTLLGKDQYDHHWSVCVAFSPDGMHLASGTDIGKVKIWEVLPSGEEKVLHNGHWKEDADDSTETRGYFIEDDGGFQKPMDYWIGAMTFTPDAKHLITGSRDQTIKMFEMPQGLEHRTLRGHTGWVRTLVVTPDGKVLISGSDDNTIRFWDLATGRCFRTIKTHTGGVRCVALSPDGLSLASASWDRTVKLWSGGPEPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I081</accession>
    <name>A0A1W1I081_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase, FkbM family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0236"/>
    <dbReference type="EnsemblBacteria" id="SLM46408">
        <property type="protein sequence ID" value="SLM46408"/>
        <property type="gene ID" value="NSJP_0236"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0236"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="57"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="279" mass="31273" checksum="AD97D2B179385A11" modified="2017-06-07" version="1">MRAGVKKLIQRTARAFGIEIRRIQPVAAGEPGSERPSLEGSLTQAREAGLDPKTVIDVGAAVGSFTRTCRGVFPDARYLLVEPLEEYLPSLDKVVKDIPGATYELAAATDHRDGVMVNIHPDLVGSSLYRETEEGSEVNGIPRKVPSVTVDALVRERHAEPPYVLKIDVQGAELDVLAGAERVLQRTDLVLLEVSLFQFFERGPVFCDIVEFMKTRGFVPYDILNLQYRPLDHALSQVDISFVKENGAFRRHHYYATPDQRHDQNVRFRSHLIRLLSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I083</accession>
    <name>A0A1W1I083_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative PP-loop ATPase, YdaO type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0222"/>
    <dbReference type="EnsemblBacteria" id="SLM46394">
        <property type="protein sequence ID" value="SLM46394"/>
        <property type="gene ID" value="NSJP_0222"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0222"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="2">
        <location>
            <begin position="50"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="312" mass="34931" checksum="6CE13FC61F0DB87D" modified="2017-06-07" version="1">MNCTKCKTRAVIKLPRHHAAFCKDCFNGFVHDQVAKAVKSQKMFGKEARILVAVSGGKDSLALWDILLKLGYRADALYVNLGIGSYSERSHEKVRRFAEAIAAPLGAALHTHTVEQEEGAGIRELAMLVHRPTCSTCGTIKRYQFNRAAIEHEYDVMATGHNLDDEAARLLGNVLHWQEDYLDKQSPSLPASVEGFAKKVKPLYRLTERELAAYCVLNKIDYIVEECPMAQGAKTLLYKEVLNRLETESPGTKHTFYWGFLDRSRKETGSQATMEQKDRTALHPCQTCGQPTTAEICSYCKLMTRAKTPSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I084</accession>
    <name>A0A1W1I084_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46410">
        <property type="protein sequence ID" value="SLM46410"/>
        <property type="gene ID" value="NSJP_0238"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0238"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="226" mass="25986" checksum="9005C72CB5B89429" modified="2017-06-07" version="1">MPTLDWLRAEFHYGYDSGDVLSWIPGRRRWGEERKCGGSYRRVFTRVVRPRLFADSKVLELGPGRGSWSRAILRHIPNGELHTVDFQDVSPWLHPDLSAGRLVCHRVQDNTFAGLPDRYFDFFWSFGVLCHNEIESIGDILRSARAKMKTGGIAAHQYGDWSKLDHFGWERGGVPTEFRNKPDREIWWPRNDQATMCRIAGEAGWEVLQGDVGLLGRDPIIVLRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0C2</accession>
    <name>A0A1W1I0C2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative periplasmic serine endoprotease DegP-like</fullName>
            <ecNumber evidence="9">3.4.21.107</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">htrA</name>
        <name evidence="9" type="ORF">NSJP_0167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.107" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0167"/>
    <dbReference type="EnsemblBacteria" id="SLM46339">
        <property type="protein sequence ID" value="SLM46339"/>
        <property type="gene ID" value="NSJP_0167"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0167"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011782">
        <property type="entry name" value="Pept_S1C_Do"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02037">
        <property type="entry name" value="degP_htrA_DO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012686952" evidence="7">
        <location>
            <begin position="30"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="271"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="430"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR611782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="498" mass="51738" checksum="8FDFE6A363957213" modified="2017-06-07" version="1">MVKWSRVCMPLSVLSCVVILSSALPGAQAAGVPPSMAQGFSDIVKKVTPAVVNIAVTGGGEGGRGRRPLPPGPFGGPPGGPPGGDEPGGELPTPPPMPPGGPHRPDQSAGSGVILDANGYIVTNNHVVEGATQITVTLSDRREFSAKIVGTDPKTDLAVVKIEAQDLPSLKWAEYEKLQVGDLVLAIGSPFGLSSTVTLGIISALGRGNVGIADYEDFIQTDAAINPGNSGGALINMNGDLIGINTAIFSRTGGSEGIGFAIPSSIALDIVESLQKTGKVVRGWMGVAIQEITPALAKSFKLPEQRKGVLISDVNENGPSHAAGVKRGDVVIAFNGKEVQSVSQLRNLVARTVVGKDAQVKILRDGKEQTLSVKVAERPSDEMLAKKESAPQKEQGETVKPPDNVLASLRVQALDNATMSQLNIPSKTTGVVVSSVEPGGPGEAAGIQRGDVIQEVNHEAVKSLEDYHKAAQKIKKEELAVLLLSRQGNNLFVAVNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0C5</accession>
    <name>A0A1W1I0C5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fused ribosome-associated ATPase: ATP-binding protein ATP-binding protein putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rbbA</name>
        <name evidence="11" type="ORF">NSJP_0283</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0283"/>
    <dbReference type="EnsemblBacteria" id="SLM46455">
        <property type="protein sequence ID" value="SLM46455"/>
        <property type="gene ID" value="NSJP_0283"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0283"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="576"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="729"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="781"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="809"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="903"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="15"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="280"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="312"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM46455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="926" mass="101332" checksum="B22735696F870A38" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0F3</accession>
    <name>A0A1W1I0F3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46488">
        <property type="protein sequence ID" value="SLM46488"/>
        <property type="gene ID" value="NSJP_0316"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0316"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="347" mass="38063" checksum="0BD445D6EB64ADE8" modified="2017-06-07" version="1">MLADRTNRVAAGALIRLSFTLASLLSLHDPAYGIDWVPTDAEMARYRESWNPPTHGTTFTSSADLARQGQWYVRAYVQGQIGSGQYVNSPSSTSTATPFSPDAVSPAAILYYGLTRHVSVAMGVSWIYWRSDKPDSEGNTSGGGIGSTSLIFKYRPIVQNPDSWRPSISLYTKLSLPTNRWFGTPEIPGGFTPLSRVPSSRFEAAAVTEGLLFRKNVEPFRITGNVFYSYNLPGPSSTVGMTAYAGDLISSHLALEHVLDQRTGFGYLLEFATLNQLTTRLDGHPTNTTPASFWLLGVQPGLEYTFSRYESGAKLVGAIGVMFTIAGQNDIRAVYPNISFKYFFDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0H5</accession>
    <name>A0A1W1I0H5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46482">
        <property type="protein sequence ID" value="SLM46482"/>
        <property type="gene ID" value="NSJP_0310"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0310"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="130" mass="14723" checksum="79CAF1ADE8DBFCC2" modified="2017-06-07" version="1">MDDKKMLKRNTLVLGVMMAGCLTLLQTGCAADKAKRDVSGPYQTWDDVVNRWIGGDRQKLYLELGPPNLHPHELPDGRTEMVWDFAIDRMPGQADEYNLFPLYGSNLNCQLHFFADEKGTILDGYRVGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0I7</accession>
    <name>A0A1W1I0I7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46501">
        <property type="protein sequence ID" value="SLM46501"/>
        <property type="gene ID" value="NSJP_0329"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0329"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="67" mass="7310" checksum="0E2A0F107D75B688" modified="2017-06-07" version="1">MALAPPDCLTWHGGSRLAVLFPQRSVLVAGRRRWSMKALLGKCGDRGLAWVMIGLFALFVLGLNLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0M6</accession>
    <name>A0A1W1I0M6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46527">
        <property type="protein sequence ID" value="SLM46527"/>
        <property type="gene ID" value="NSJP_0355"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0355"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="436" mass="48122" checksum="329CF134CA453E4B" modified="2017-06-07" version="1">MMSSMVRLLNVRAITVAMIATVLFLFGCATTLVAAQEQLDLPRYSLQVPAGWSSQVDGERWMLYPSGGANELGIAPVGTGLQLGETLTRADAHRQLWASALSSRQVLQANPTQQDKDDLGRQWTVDSAIIQEAGTPYLLLLSVVELAGRAEGFLTVGTPSALERHQKSIDAVLNSVRPREPAKTQAARMREKAPVFGRPSPLGTSGPGRLTGVWTATTHELRYGTTGLANKPVVSELILFADGTALWGMPGEGLLGFDRTAYRARWPERWGAYTARDKQVIVTRGKEERLYAVLQDGVLEHRYIEGGKERTGERFIPRPSLDGVRLDSEVRRKDHWPAPGNASGLGTLKGLSFSRDGTFHDDKLMWIVSPDREGESKEAHEARVLPGQGHYRFEHWTLVLEYDDGRVNRVGFVATDREQPMKGAILNGYPIEPNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0M9</accession>
    <name>A0A1W1I0M9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbohydrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0383"/>
    <dbReference type="EnsemblBacteria" id="SLM46555">
        <property type="protein sequence ID" value="SLM46555"/>
        <property type="gene ID" value="NSJP_0383"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0383"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="157" mass="17849" checksum="0FB95031225DCBB0" modified="2017-06-07" version="1">MRKRFIGRSYSKTALSDPEWLGIEHLADVEVTSEDPARPIENALLPDRPSGWRAGMHGEQVIRLLFSRPTTIKRIRLEFVESVLQRTQEYTLRWSAGGSQPLQHIVRQQWNFSPRGSIREIEDHDVDLPGAVMLELTIIPDIAGTPATASLIQWRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0R1</accession>
    <name>A0A1W1I0R1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferredoxin:thioredoxin reductase</fullName>
            <ecNumber evidence="5">1.8.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Ferredoxin-thioredoxin reductase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NSJP_0414</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42336"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.7.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ferredoxin thioredoxin reductase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.8.7.2" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0414"/>
    <dbReference type="EnsemblBacteria" id="SLM46586">
        <property type="protein sequence ID" value="SLM46586"/>
        <property type="gene ID" value="NSJP_0414"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0414"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016730">
        <property type="term" value="F:oxidoreductase activity, acting on iron-sulfur proteins as donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004209">
        <property type="entry name" value="FTR_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036644">
        <property type="entry name" value="FTR_bsu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35113">
        <property type="entry name" value="PTHR35113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02943">
        <property type="entry name" value="FeThRed_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57662">
        <property type="entry name" value="SSF57662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SLM46586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="141" mass="15850" checksum="C56C8748B2B8B9D5" modified="2017-06-07" version="1">MADPKQDSLDKMWKYVKGCAEKSGTTMHPNPAVTEAVVKGLAMHVEELGKPLCPCNFYKDKQAEAKQRRWICACDEMQIYKYCHCLLFVREDGLPITEYLPEGHEGREVYGLVTDPTPDKGRGLRHKAVQVSAPVPENASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0W3</accession>
    <name>A0A1W1I0W3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46622">
        <property type="protein sequence ID" value="SLM46622"/>
        <property type="gene ID" value="NSJP_0450"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0450"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="130" mass="14581" checksum="F58B7CF9913C62FB" modified="2017-06-07" version="1">MDHHPVRWYGTARLSDDAEDAMTEEQGRLEAARKEDFLGECNAQAAGAVGRFGSRAGEGEGDGIGRCDRRNDGGNRRVRVTIVPLSCRRRTETPAKLERRQLCIVRSFSRGSWSVHSSRCPAVPVWIRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I109</accession>
    <name>A0A1W1I109_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Phosphate regulon transcriptional regulatory protein PhoB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0510"/>
    <dbReference type="EnsemblBacteria" id="SLM46682">
        <property type="protein sequence ID" value="SLM46682"/>
        <property type="gene ID" value="NSJP_0510"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0510"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="142"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="142"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="244" mass="27150" checksum="1525B19E9BE4A591" modified="2017-06-07" version="1">MMSSSQVPTMTTPKDTILLITNSEQARSAFETSLKDAGYGVLMTTNEQAALEAAQHATPSLIVADRQTCSFNRLRLQANLRSVPIIAVQDVKSVNGANDTEEETYLDDLDRGADLILCGRSARELIARVRAVLRRTELGRKPATYSFAGILQMDLDRHEVTVSGRSVNLTPKEFLILRCFLESPCRVFTRQEMLNCVWGDGYALEEHALDVHIHSLRQKIEENSGVPKLIVTVRGVGYKLRSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I114</accession>
    <name>A0A1W1I114_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0387"/>
    <dbReference type="EnsemblBacteria" id="SLM46559">
        <property type="protein sequence ID" value="SLM46559"/>
        <property type="gene ID" value="NSJP_0387"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0387"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="327" mass="37052" checksum="7BBBC5B57E8BB4B1" modified="2017-06-07" version="1">MDDKPHQATKVKLSVVIPCYNGARTIGAQLEALASQECSMPWEVVVVNNRSDDDTVGIVGQYVGRVRNLRIVDALDRQGRPYARNVGVEAAYGESIVFCDADDVVGEGWLAAMATALSRFDCVACRVDFTKLNEPALAQQHAFHDQHHGLQKTWYPPYLQHAGGGTLGVKRALHAQVGGFDEAFPVLEDTEYCFRIQETGCRIEWVPDAVLHIRCRNDEAGRFQQVRQSALYNVLLAKRYQQQAVGQFHSWGTYIKNWIRLIEALPSSRTGLAWNRWIWYFAWQVGALHGSLKFYRPPLSLPFPPPGRKENRFLARVKTRVSMMVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I173</accession>
    <name>A0A1W1I173_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">bipA</name>
        <name evidence="4" type="ORF">NSJP_0578</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0578"/>
    <dbReference type="EnsemblBacteria" id="SLM46750">
        <property type="protein sequence ID" value="SLM46750"/>
        <property type="gene ID" value="NSJP_0578"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0578"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="61"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="73"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="186"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="667" mass="74603" checksum="C0B48D7B3D30F9CC" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I181</accession>
    <name>A0A1W1I181_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rubrerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rbr</name>
        <name evidence="2" type="ORF">NSJP_0588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0588"/>
    <dbReference type="EnsemblBacteria" id="SLM46760">
        <property type="protein sequence ID" value="SLM46760"/>
        <property type="gene ID" value="NSJP_0588"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0588"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="1">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="141" mass="15525" checksum="EA33E7C26BBF8657" modified="2017-06-07" version="1">MGNSLKGTKSHDNLKHAFAGESQANRRYLYFARRADIEGYPDVGGLFRDTSEAETGHAFGHLDFLKEVGDPATGVAIGNTEANLKSAIEGETYEYTQMYPGMAKTARDEGFAELAEWFETLAKAERSHANRFQKGLDSLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I191</accession>
    <name>A0A1W1I191_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46762">
        <property type="protein sequence ID" value="SLM46762"/>
        <property type="gene ID" value="NSJP_0590"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0590"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="252" mass="27646" checksum="76296FBA3B4083A5" modified="2017-06-07" version="1">MGGAEAAAAESVVTDQPDGVAVVNQRVVAGDLFVDRHQDLLLPDQLQQVTQLYALPLNHLPHRDGRGEFDGHIPFSVHRLQLSQQLDRHHVSRMLLPGGGVDSVRRAADNADAMPSLDVQQPGMPDLQFVLFVSALCTSDVQTINVPDPVRRAIFDRCWTLINAGPPPQDPKLRVLDLREGTELTLDACLTTIRSLLLEAGITRLEWDNPVSEPSRDSTPAAKPLIERLGQLYPERPDIVDPPGDPPAADRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1E6</accession>
    <name>A0A1W1I1E6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PGL/p-HBAD biosynthesis glycosyltransferase MRA_2985 (Modular protein)</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0656"/>
    <dbReference type="EnsemblBacteria" id="SLM46828">
        <property type="protein sequence ID" value="SLM46828"/>
        <property type="gene ID" value="NSJP_0656"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0656"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="2">
        <location>
            <begin position="558"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="684" mass="76336" checksum="CDCC56BD7B7D07AE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1J0</accession>
    <name>A0A1W1I1J0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, family 2</fullName>
            <ecNumber evidence="2">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46886">
        <property type="protein sequence ID" value="SLM46886"/>
        <property type="gene ID" value="NSJP_0714"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0714"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="247" mass="28361" checksum="8F1DA5D4BA201233" modified="2017-06-07" version="1">MSAPLPWASVLVPVKDEVENLTPLTDGLLKVMHSHPLSQSRPFEIIYIDDGSTDGSSELLDRLAAEHREVRTFHFDRNHGKTAALDAAFKQSSGDIIVHIDADLQQDNEDILSMLPLTERYDVVCGWRKDRQDNLVRKLSSRIANFIRNIFTRDGIHDTGCPLKIFRRPVCEKLCLFEGLHRFFPALALMHGFTITEVPVRHYPRLHGVSKFGVGNRLFKSLYDLIAVRWMHSRVLRYRFRSSPVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1J2</accession>
    <name>A0A1W1I1J2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46857">
        <property type="protein sequence ID" value="SLM46857"/>
        <property type="gene ID" value="NSJP_0685"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0685"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="49" mass="5421" checksum="CBA8882815FAEBE6" modified="2017-06-07" version="1">MRPCTVHNAPQIEKRIMEAGAAAFLSKEVAVDSLYKTIHAVKPRTRAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Q1</accession>
    <name>A0A1W1I1Q1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rimP</name>
        <name evidence="6" type="ORF">NSJP_0768</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimP family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0768"/>
    <dbReference type="EnsemblBacteria" id="SLM46940">
        <property type="protein sequence ID" value="SLM46940"/>
        <property type="gene ID" value="NSJP_0768"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0768"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DUF150" evidence="4">
        <location>
            <begin position="15"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="DUF150_C" evidence="5">
        <location>
            <begin position="90"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="158" mass="17554" checksum="2146630DBD3395C1" modified="2017-06-07" version="1">MKESRPVVERITEAISPILWTLGLELVDVLCVGQGSRSVIRVFIDKPGGVTLDDCERAHVALGPALDVADPFPHAYTLEVSSPGLDRPFKRIQDYRRAIGKRISLKLKEPRAGQWRIVGRLNDVTEQAVTIAVADPSPERVMNLDFESIAEARLVVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Q6</accession>
    <name>A0A1W1I1Q6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 16">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="6 16">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">hom</name>
        <name evidence="19" type="ORF">NSJP_0750</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="6 16"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0750"/>
    <dbReference type="EnsemblBacteria" id="SLM46922">
        <property type="protein sequence ID" value="SLM46922"/>
        <property type="gene ID" value="NSJP_0750"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0750"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 16" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11 15 16" id="KW-0521">NADP</keyword>
    <keyword evidence="12 16 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="18">
        <location>
            <begin position="356"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="SLM46922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="437" mass="46498" checksum="D78DF601BFA71583" modified="2017-06-07" version="1">MRSRVGVGIIGFGTVGSGVARILQNNAAIIRRRVGVPLEVVRIADLDVTRSRGIDLAPGVLVNDVKQVVADPHVDIVVELIGGCDFAKRILLDAMESGKHVVTANKALLALHGEELFAAAARKGVDLGFEASVGGGIPVIRAVTEGLAANAIQSIYGIINGTSNYILSRMTNEGQGFAENLAEAQRAGYAEADPTFDVAGTDSAHKLAILANLAFGSPINFKELYTEGITHITPHDIAYAREFGFTIKLLGIAKLVDGEVEARVHPTMLPADSPLAKIEGVYNAIQLVGDAVGDVVLVGRGAGDMAAGSAVVSDIIASARHLLKGGAGRVPPASFQQDQRRPLRMRPMEEISSLYYLRFMVLDRPGVLAQIAGELGRFGISISSMLQKGRRAGQTVPIVIKTHTAQERSVQMALREINRMDFMSEPATLVRVEGKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1T6</accession>
    <name>A0A1W1I1T6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0780"/>
    <dbReference type="EnsemblBacteria" id="SLM46952">
        <property type="protein sequence ID" value="SLM46952"/>
        <property type="gene ID" value="NSJP_0780"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0780"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="235" mass="25780" checksum="72A7D67E99717668" modified="2017-06-07" version="1">MADEAPAKLIQIGPKGGAKKDGFNLVTERVVAVNPEAKQVEVELLAYDGKTVLLDVDEEALEELKQLKVGDGATIRVIEEGGRRVAKSFRIRPKDPTAARADAMLLDLKDTHWLNRKYAAEILGELKEGRAVKPLVEALTDEVGDVRQRAYDSLIKIGGAAVSSLVPLLVSEEDELRQSVTEIIRKIGKPAVEPLATALAEADDRLKTRILKVLDRMGYKPKAKDEEKAEVPRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I264</accession>
    <name>A0A1W1I264_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">mfd</name>
        <name evidence="11" type="ORF">NSJP_0926</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0926"/>
    <dbReference type="EnsemblBacteria" id="SLM47098">
        <property type="protein sequence ID" value="SLM47098"/>
        <property type="gene ID" value="NSJP_0926"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0926"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="619"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="801"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM47098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1152" mass="127987" checksum="5F4F7D1EA8973287" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2B4</accession>
    <name>A0A1W1I2B4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0984"/>
    <dbReference type="EnsemblBacteria" id="SLM47156">
        <property type="protein sequence ID" value="SLM47156"/>
        <property type="gene ID" value="NSJP_0984"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0984"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="14"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="224" mass="24240" checksum="AB6224B93E67C99F" modified="2017-06-07" version="1">MTAALSKRRVFMTGASGYLGSRLIPLLLDAGHSVHALLRASSRHRPPAGCTCLWGDPLDGATFQDGIRGCDTFLQLVGTPKPAPWKGAQFRNVDRVSGLASIAAATQSGRPHFIYISVAHPAPIMKDYIAVRAECETALVGSGMPATILRPWYVLGPGHWWPILLAPAYRIAEQWPSTSEAAGRLGLLTIQDMLNALVWSVEHPAETIREMNVPDIRRLTGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2J6</accession>
    <name>A0A1W1I2J6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47212">
        <property type="protein sequence ID" value="SLM47212"/>
        <property type="gene ID" value="NSJP_1040"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1040"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021327">
        <property type="entry name" value="DUF2934"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11154">
        <property type="entry name" value="DUF2934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="67" mass="7451" checksum="62BDE79FDC77B61A" modified="2017-06-07" version="1">MSKRTAKQPGSSGIKRVIFGTGGNGPNAQDLQQQIALRAYELYLERGAVDGRAEDDWFRAEREVRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2P8</accession>
    <name>A0A1W1I2P8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sensory sigma-54 dependent transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1114</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1114"/>
    <dbReference type="EnsemblBacteria" id="SLM47286">
        <property type="protein sequence ID" value="SLM47286"/>
        <property type="gene ID" value="NSJP_1114"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1114"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="5">
        <location>
            <begin position="153"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="453" mass="49890" checksum="240D3A4F8CB08F2F" modified="2017-06-07" version="1">MAGSQQDSVDNPSIADPVLNARLDAIRSLAGGLTDRVAVMDRHFNVMYANDAAWSTASADEQPDAKCYQAFAHRRQACETCPALKVIETPDASMVCFPEEDDTPCGMRRAFPLASSLGETTSMLVLFKHNESQSRISRQPSVSNTRHDTLCGLVGHSPAMRELFDMIRLVADSSATVLIQGESGTGKELVARTIHELSERKSRPFVVVDCGSLPETLLESELFGHVRGAFTGAISDKRGLFQTAEDGTIFLDEIGDTTPTFQAKLLRVLQESEIRPVGSTERIRIHARVVSATNKDLAELVGAKAFRQDLYYRLAVLPLFLPSLRDRREDIPLLVKRFLAASCERHHQPMRTVSSQVLQTLSEAAWPGNVRELQHYIERAVVTTAGPALICSDLAAKPSWPKTEDLRSAARQAERLRIGEALSAMSGNRVKAAKLLKISRSSLYNKLREHGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2S0</accession>
    <name>A0A1W1I2S0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47294">
        <property type="protein sequence ID" value="SLM47294"/>
        <property type="gene ID" value="NSJP_1122"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1122"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="84" mass="8710" checksum="D9C17EFBD0C0DFCB" modified="2017-06-07" version="1">MIHATNQIGDAPRAEHEVPAAVLAVPGAFMRPAASFNLFTTSIFKSLSIPPAAVQPPPAADAAAEPSSSLHPPVLALTLFPPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2T6</accession>
    <name>A0A1W1I2T6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47326">
        <property type="protein sequence ID" value="SLM47326"/>
        <property type="gene ID" value="NSJP_1154"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1154"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="88" mass="9099" checksum="4A067A0BA9F30B1F" modified="2017-06-07" version="1">MRRRTAEGAGMTLAILYWLLTGESVAAASSDPQLDPKAGETMADPRPAPGTGPTFPNPPAPEPPTPVPPAPPPPSPQPNPPPQPRPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I369</accession>
    <name>A0A1W1I369_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47415">
        <property type="protein sequence ID" value="SLM47415"/>
        <property type="gene ID" value="NSJP_1243"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1243"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="199" mass="23104" checksum="11EFE485A6EC2E4B" modified="2017-06-07" version="1">MESENEYKWPKKGDRLLRAENDWHRSVSFAEHEIARHAHIWNGYMQAGRMLVEACHPNERALRHELVYPILFCYRHGLELALKWIIDRYRGYTDIPAEDYANHNLWQLWKVCKKIMIALEADGDTECLVAVEHVVKDFHELDKSSFSFRYSTDKKGALVCLPDVPFDVPNIKDVMEAVNNFFSGADGLLDNNSSASGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3M7</accession>
    <name>A0A1W1I3M7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">7-carboxy-7-deazaguanine synthase</fullName>
            <shortName evidence="5">CDG synthase</shortName>
            <ecNumber evidence="5">4.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">queE</name>
        <name evidence="7" type="ORF">NSJP_1317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:27974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="EC" id="4.3.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </cofactor>
        <text evidence="5">Binds 1 S-adenosyl-L-methionine per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.3.99.3" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1317"/>
    <dbReference type="EnsemblBacteria" id="SLM47489">
        <property type="protein sequence ID" value="SLM47489"/>
        <property type="gene ID" value="NSJP_1317"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1317"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00917">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024924">
        <property type="entry name" value="7-CO-7-deazaguanine_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027621">
        <property type="entry name" value="rSAM_QueE_gams"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000370">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04349">
        <property type="entry name" value="rSAM_QueE_gams"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="16"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="35"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="211" mass="23690" checksum="A493C25B771D9A3F" modified="2017-06-07" version="1">MRITEIFHSIQGESTYAGEPCVFVRLTGCPLRCTWCDTAYAFHEGQEMSLADVMTAVKSYGCRLVEVTGGEPLAQSQTIELIESLCETGYKVLVETSGAIDISPVDRRAQIILDVKCPGSGMTERMWWPNLAQLTAKDEVKFVVAGRSDYDWAVGIIERYGLTGLCPVLMSPVFETLEPRQLAEWILRDRLPIRFQLQLHKFIWAPDARGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3M8</accession>
    <name>A0A1W1I3M8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">infC</name>
        <name evidence="8" type="ORF">NSJP_1455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1455"/>
    <dbReference type="EnsemblBacteria" id="SLM47627">
        <property type="protein sequence ID" value="SLM47627"/>
        <property type="gene ID" value="NSJP_1455"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1455"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="7">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="6">
        <location>
            <begin position="96"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="182" mass="21238" checksum="76F77CAE7ACA592C" modified="2017-06-07" version="1">MHNNFHRHHERWPIVPKLRVNREIRVREVRVIGPEGEQLGILPTPEAFRQAQEGGYDLVEVAPTSAPPVCRIMDYGKYKYELSKKDHQNRRHQKSTQVKEIKLRPRTDKHDLEIKVRQIKTFLEEGNKTKITLTYRGREMANQEMGRSLMSSVIEQLADTGTIEYAPRMEGRSLIMIVAPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3T6</accession>
    <name>A0A1W1I3T6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47611">
        <property type="protein sequence ID" value="SLM47611"/>
        <property type="gene ID" value="NSJP_1439"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1439"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012529058" description="OMP_b-brl domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl" evidence="2">
        <location>
            <begin position="29"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="244" mass="26927" checksum="D71121C8DD4AEF0C" modified="2017-06-07" version="1">MVHRRRVQPLILWSFVLLFLVPHETSAEMYADIYGGAVFTNKTDVTVSSTSGTTTTNQGLSVSDTWTVGGRTGYWLDRFDWLGFGLDVFFFRVNAPGQSVPSTVTSGGQTTTSPAPFQWSLPVFGIGFDVLRLRIPLLRSDAFPHGRLQPYMSAGPSLFITYAGTPMNVQPQNQHETDVSVGAKVDAGVTFMLTKNIGLFTQYRFTHFTSELSYQNAVTGFSTDSYRATFDSHHVLGGLSIQFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Y3</accession>
    <name>A0A1W1I3Y3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1538"/>
    <dbReference type="EnsemblBacteria" id="SLM47710">
        <property type="protein sequence ID" value="SLM47710"/>
        <property type="gene ID" value="NSJP_1538"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1538"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT" evidence="1">
        <location>
            <begin position="145"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="355" mass="41448" checksum="15B887813682EB52" modified="2017-06-07" version="1">MARWRRRFLYLLPLVMGVRLFLVSGAWAESDPVTPKEGMPRLGANGESERDLLPGEVIDGQMEPEERLVILPEIKREGERFFLSSFKLPDKLTFAGQPIPMDNWQVRERIEYEFYQFLEDQGESIILAKRMGRCFPPAEKQLAEAGLPDDLKYMLLVESKCIAAAYSRAKASGPWQFIPSTGRRYRLKSDSVRDDRRNLEMSTEAAVKYLKYLKDFQQNDWFLAMASYNAGEERVRKLLKDQKINDYWRMHGPRETMRYVPRIIAAKEIYSQPEKYLGLSKKDLYLPLETETVTVTVKESQRALTSIAEEFGTYYLELRMLNPEFKKDVLPHGVYQIRVPRQTCPSRCFKQEKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Z1</accession>
    <name>A0A1W1I3Z1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pmtA</name>
        <name evidence="3" type="ORF">NSJP_1550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47722">
        <property type="protein sequence ID" value="SLM47722"/>
        <property type="gene ID" value="NSJP_1550"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1550"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="45"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="237" mass="26571" checksum="4559DF9EF57F41F1" modified="2017-06-07" version="1">MDLHKIERVYTSYAGVYDKIFGKVFHEGRESAIRNLNVQPSERILEVGVGTGLALPMYPRHCRIVGIDFSEGMLDVAKKRAIEHQMDHVTLHRMDAGAMEFEDNSFDTVVAAYVVTAVPDHRKLVNEMIRVCRPGGRIIMLNHFSNGNKVIAAVEKVISPLTKHLGWRTDLALHTVLEGTNLHVTRKQNVNPLRFWALVECVNRKHESGRPRLNGTTVFSPSSDNRTAGHASEEALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I410</accession>
    <name>A0A1W1I410_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_1562</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47734">
        <property type="protein sequence ID" value="SLM47734"/>
        <property type="gene ID" value="NSJP_1562"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1562"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="7"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="259" mass="28556" checksum="8C02B50B26F1C758" modified="2017-06-07" version="1">MNEYWQEIHALTMRWVRRLSREKFSMLFTLVQPMLFWLIFFGNLFQRAADSQVMQAPNYISFLAAGVVVMTVLNNGLAGGVDLLFDKENGFLERLMSTPIRRSSVILSRFLFVMTITSLQVLVILGVAFLFGVRPATGLLGIAVILLIGILFGVGLTAISMAMAFSVKSHGDFFSVLGFLSLPMIFLSSALVPLAAMPGWMGFLAQFNPMTWAIDAVRPLILSSWADALPHVGMVVVVMIVFDALCLYGGAKAFRRAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I450</accession>
    <name>A0A1W1I450_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit K</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit K</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">nuoK</name>
        <name evidence="6" type="ORF">NSJP_1625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1625"/>
    <dbReference type="EnsemblBacteria" id="SLM47797">
        <property type="protein sequence ID" value="SLM47797"/>
        <property type="gene ID" value="NSJP_1625"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1625"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="PTHR11434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="5 6" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="101" mass="11135" checksum="C99A6883D62576A0" modified="2017-06-07" version="1">MTVPLSFYLILSGVVFLTGLVGVLIRRNIIIILLSVELMLNATNINFVAFSEYFHHAAGQVFVFFALTVAAAEVAVGLAIIIALHRSKSTINVDEFQLLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4E4</accession>
    <name>A0A1W1I4E4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47870">
        <property type="protein sequence ID" value="SLM47870"/>
        <property type="gene ID" value="NSJP_1698"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1698"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="353" mass="39816" checksum="638DC624C22BF64C" modified="2017-06-07" version="1">MRERRWETTTPLSFGQVLAVGDRLATLGLKPAVAAKDVICYVEDWKVEAPEDLDGLDAWATEDVTLVHVRSGWRGDFFLLAGAYHTVYQRHQNLGTYCSISHPWRNREPLVHHESRNMLWLGFRHAHSFVRVRLQTREVISPGETRGDDRREQWLEERRTAFLEAITSLEVPVETAIDKQQVVLHPVDPHVPFFCSWPDAFGPCQFEYNTTDAYEFLVPASRLAATFAPEPAGVRAYLTGFSEEALGEFAAIEPQAGLAYRCSVHCPLDDLPEIRSVIEPEGRLYATLCEFQTQDLIPEQDDASAIVGVMGTGAGFHLEVRLNRAPLPEEQMAGWLERLVGYPVVYAPLPAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4F1</accession>
    <name>A0A1W1I4F1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoenolpyruvate phosphomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1710"/>
    <dbReference type="EnsemblBacteria" id="SLM47882">
        <property type="protein sequence ID" value="SLM47882"/>
        <property type="gene ID" value="NSJP_1710"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1710"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="317"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="559" mass="61868" checksum="A25E766302067DAC" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4S1</accession>
    <name>A0A1W1I4S1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">ispH</name>
        <name evidence="6" type="ORF">NSJP_1832</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1832"/>
    <dbReference type="EnsemblBacteria" id="SLM48004">
        <property type="protein sequence ID" value="SLM48004"/>
        <property type="gene ID" value="NSJP_1832"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1832"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="222"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="320" mass="35200" checksum="00686DCBAC3DD4CF" modified="2017-06-07" version="1">MKIYLANPRGFCAGVDRAIDIVDLSLRKYGAPIYVRHEIVHSRHVVNSLRQKGAVFVEELGEVPEGSVVIFSAHGVAKSVWDEANRRRLHVIDATCPLVIKVHNEVNRDYTQGYDLILIGHAGHPEVIGTLGQIPDKFHLVSSVEDVEKLQVDNVHSLSYVTQTTLSVDECRDIVGALHRRFPNIKGPHQEDICYATQNRQNAVKELSKLVDVILVIGSPNSSNSNRLRELGEHCGIASYLIDSASDINPTWLNGVKAVGITAGASAPEVLVTEVVAYLKTYGTAEVEDLTVIEEDVEFLLPKELITIESSKQSVTAPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4S3</accession>
    <name>A0A1W1I4S3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bifunctional IPC transferase and DIPP synthase</fullName>
            <ecNumber evidence="5">2.7.7.74</ecNumber>
            <ecNumber evidence="6">2.7.8.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NSJP_1717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol = bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31327"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:62573"/>
            <dbReference type="ChEBI" id="CHEBI:62576"/>
            <dbReference type="EC" id="2.7.8.34"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1D-myo-inositol 3-phosphate + CTP + H(+) = CDP-1L-myo-inositol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30647"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:62573"/>
            <dbReference type="EC" id="2.7.7.74"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the MobA family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.74" evidence="5"/>
    <dbReference type="EC" id="2.7.8.34" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1717"/>
    <dbReference type="EnsemblBacteria" id="SLM47889">
        <property type="protein sequence ID" value="SLM47889"/>
        <property type="gene ID" value="NSJP_1717"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1717"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="461" mass="49204" checksum="BFDC9275D42027F1" modified="2017-06-07" version="1">MGESLLDQRADLQGLSTAILLPSVDLFGAPVRGAVGPLTPIVGISLFQRAVLTFQRAGIRQLIVVAGAEEEALKHALGKGPRVTIPVRWMPIREFPLDDPRTWEALAAEARGFCLVSGATGIFSRALVEQLRQDVQEGHAIVVAPGRPRPGTSQGDVGSTRRLVESGTGEAADLVVLPVNILNAAGSATRESGTIPVRRWIEQAAATGRLRVCSTGSNQAQWYRAVRNSRDVRAAENQLFASLKSDLEGFVDRYFNRILSRRFTRVFLSLGLSPNAVTMLATFVGLAAAAGFAMGTYAAGLTAAVLFQLAAVIDCSDGEIARLTFTESPFGAWLDIAMDNVVHMAIFGGIAWGSYTAGSGDPYAWVPLVLGAAAILGNALSFGLVGKAQKIKAANGWKTLAQAARSEFILQNLASRDFSVIVLLFALVGRLEWFLWLAAIGSLTFAAIMFWVVRFSSTGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4T6</accession>
    <name>A0A1W1I4T6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Toluene transporter subunit: membrane component of ABC superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yrbE</name>
        <name evidence="8" type="ORF">NSJP_1838</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MlaE permease family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1838"/>
    <dbReference type="EnsemblBacteria" id="SLM48010">
        <property type="protein sequence ID" value="SLM48010"/>
        <property type="gene ID" value="NSJP_1838"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1838"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003453">
        <property type="entry name" value="ABC_MlaE_Proteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00056">
        <property type="entry name" value="TIGR00056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="256" mass="27547" checksum="93418FF70105B1D8" modified="2017-06-07" version="1">MNRLLERMGARALAMVGEMGRMLLFVASSFAWLARPPFRPIQVVKQLHFVGYKSTFVVVLTAGFTGMVLALQGYYTLRKFGSEGLLGSAVALSMIRELGPVLAALMVTARAGSAMTAEIGIMRITEQIDAMDTMAINPLQYLVAPKLLAGLIGVPLLVAIFDVVGIYGGYLVGVELLGGNGGAYWNSIESAVEWKDIYGGILKSISFGLIVSWICCYKGFFTKHSAEGLGSATTEAVVLSSVLILVWDYFLTSILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4U0</accession>
    <name>A0A1W1I4U0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC transporter, periplasmic binding component, ATP-dependent toluene efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yrbD</name>
        <name evidence="3" type="ORF">NSJP_1840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1840"/>
    <dbReference type="EnsemblBacteria" id="SLM48012">
        <property type="protein sequence ID" value="SLM48012"/>
        <property type="gene ID" value="NSJP_1840"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1840"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="39"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="147" mass="15441" checksum="46D1F0BC480545D2" modified="2017-06-07" version="1">MEKTKLELIVGVFVLIGIVCLGYLSIKLGKLELVGGNVYEVVAQFNSASGLKPGSAVEIAGVEVGRVRGIVLKDDRASVTLAVHDNVKLYSDTIASIKTRGIIGEKFLALSPGGGGDALKSGDTIRDTESGLDLEELVSQYVHGKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4W8</accession>
    <name>A0A1W1I4W8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48025">
        <property type="protein sequence ID" value="SLM48025"/>
        <property type="gene ID" value="NSJP_1853"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1853"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="329" mass="35767" checksum="3297FEC409ABFB73" modified="2017-06-07" version="1">MAEERESLSPTKIGLGVLWPAFWTGLAFKLAFVLLFLAMGIMHFEGRLGLAFIMLLASPVTVFALPIITMGLDSHIGEGAGIALLFLLSIPIDIWALGIVGRTFFLERLRREPPDGLGMTLWWKSALVGAIFLPILWLVVGTVTSTSIAVAHSLLELEFLKWIPIAERISIELTLWGSVASAVLIILLLIGVSLIGRLIRNMAQSAPAVSENYQGLITRWDLMRVPTDQSLMLTSLTGAGAILSVLFWMALPVTTPHPHECCKKPEVKAEPPVKPLESLTKNEKVIAQLSAQVDALEKQKTDKPEAETDKGKAKGKAGKDKDGPPAKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4X0</accession>
    <name>A0A1W1I4X0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48046">
        <property type="protein sequence ID" value="SLM48046"/>
        <property type="gene ID" value="NSJP_1874"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1874"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="104" mass="11145" checksum="F91616ADB7E431E0" modified="2017-06-07" version="1">MPTVSMRSSIAIRGSWMLLILYVLLALSLQPLLLEHVFAAGSAHEHSDQDVCAWLDHAASAGLQSIKPPASLLQCLLASPLPVDIAFPTAESFFDPIRGPPLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I563</accession>
    <name>A0A1W1I563_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48125">
        <property type="protein sequence ID" value="SLM48125"/>
        <property type="gene ID" value="NSJP_1953"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1953"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021493">
        <property type="entry name" value="DUF3147"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11345">
        <property type="entry name" value="DUF3147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="113" mass="12108" checksum="FA3F01FD7EEC331C" modified="2017-06-07" version="1">MWEDLLFRFVIGGTVVSLFALLGDVFKPKTFAGIFSAAPSVALGTLGLAIIEHGTGYAAIEAKSMVIGALALFVYCSLVSWIMLRYTWHSLVVATSAIIVWLGVAFGLRALIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I594</accession>
    <name>A0A1W1I594_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylserine decarboxylase proenzyme</fullName>
            <ecNumber evidence="5">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="5">Phosphatidylserine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="5">Phosphatidylserine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">psd</name>
        <name evidence="7" type="ORF">NSJP_2015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="5">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2015"/>
    <dbReference type="EnsemblBacteria" id="SLM48187">
        <property type="protein sequence ID" value="SLM48187"/>
        <property type="gene ID" value="NSJP_2015"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2015"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00664">
        <property type="entry name" value="PS_decarb_PSD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033175">
        <property type="entry name" value="PSD-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35809">
        <property type="entry name" value="PTHR35809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00164">
        <property type="entry name" value="PS_decarb_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="4 5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 5" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023391037" description="Phosphatidylserine decarboxylase beta chain" evidence="5">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023391038" description="Phosphatidylserine decarboxylase alpha chain" evidence="5">
        <location>
            <begin position="185"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="5">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="5">
        <location>
            <begin position="184"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="5">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="216" mass="23246" checksum="74AC76520B7BF015" modified="2017-06-07" version="1">MADRAVGIPVAKEGIPFIAVAAGGTLATGWMGWPIAAGAAGLLTLFVSWFFRNPPRTIPQGARLVVAPGDGKVIAVEEEFEPRYLKDRSIRVTIFLNVFDVHINRIPCEGTVENVQYQPGQFLVASKPEATIKNEQNALMIKAGQGAKVLCVQVAGLIARRIICWVSPPERAVLGERFGLIRFGSRMDTFLPLGSVIKVAVGDRVKGGESILGELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5G8</accession>
    <name>A0A1W1I5G8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48240">
        <property type="protein sequence ID" value="SLM48240"/>
        <property type="gene ID" value="NSJP_2068"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2068"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="160" mass="17956" checksum="E7EB41C7DEC30FC8" modified="2017-06-07" version="1">MAGLMSADEVFEKAQAAAVGATNPDEKALQIDYPALKEKIHAALGDRKVALCHINRFLPEGYEDQGRFNLVLLTAGNVVFDIVIGDSYFRYDVLSVGQLDKVQVIDAMWDNREKRREEPFLSLRLMHAEETHLLLALDEDERKSLLAFAKAVSAARNPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Q5</accession>
    <name>A0A1W1I5Q5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48348">
        <property type="protein sequence ID" value="SLM48348"/>
        <property type="gene ID" value="NSJP_2176"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2176"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="160" mass="17631" checksum="26D85D10A00F00CD" modified="2017-06-07" version="1">MSETVSHSRFRRTTVILYWACIGLGLTIPWFAVILVDLLKHRQSIGQALHQWRIHLFAPGYNLFLVGLLNAVPFVLLALFLLLHLGRTSSHSFPLAGRRMLGVTTAALAAIGLSAWVQFSTLWFPDAQGALAYIFLPIGLTGLLPVGYAVGRVLGRLLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5S0</accession>
    <name>A0A1W1I5S0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Phosphate-binding protein PstS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2185"/>
    <dbReference type="EnsemblBacteria" id="SLM48357">
        <property type="protein sequence ID" value="SLM48357"/>
        <property type="gene ID" value="NSJP_2185"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2185"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_domain" evidence="1">
        <location>
            <begin position="38"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="290" mass="31381" checksum="32E12ED4711D4F15" modified="2017-06-07" version="1">MFGEAIRRLLHRLFGPRPAYLRGAFAVLGLGLWLTVTGSATAEVSGNLIIAGNGPEQPIIELLVRAFERANPRAYVDVVWDDHSKAVEMVKTGEAHLAVTGSEDGGLASTQIAWDGIGILVHLSNFTKEVTKQQVADIFSGKVKEWSELGGPETKILLIDRPRNQNVRDAFESELGITGKIPDTAKVIARDDKVVKTVVGTLPPLSAVSYISLSQGLSVVSGGVAVRLLPIDKVEPEVPTVKDGRYPLRRPVLLLSRKEPNPLVEAFIQFALSPPGQQIVTEAYVPVTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5V1</accession>
    <name>A0A1W1I5V1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2149"/>
    <dbReference type="EnsemblBacteria" id="SLM48321">
        <property type="protein sequence ID" value="SLM48321"/>
        <property type="gene ID" value="NSJP_2149"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2149"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="443"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="505" mass="56034" checksum="58425274154CC84A" modified="2017-06-07" version="1">MDAQSNTIIPDSVPPPQPDTSSWWRATDVPPPVGEYSHRFSPVISVLAAVFLVLALTSVVWLSLSIPKLDRMDAPEAALARMVSRTMDAQEGLRRAPEWKQLVLAWITGDSESERLQAITWYRELAQVSEDPVVPLQLAVLQAESAQVSQALLSAHEWDRLDEPFPQAARLIRAAYAEGTTPDRESLDRFQAEAAELLPAGWFYDRLAERLAMKAGNQELASSIQASSTARADRMFNLSWKLTFVELLAMLFGTVVLIRVWLTRKRDTDPIRLHSIGVPPPWPGGVGAAVLLRGGALGALFTAMFLFYMPPENASLRALAIPMSNVPLLLLAYYHLFRPSGLSFDEGFGLDVPWNRLGRLAAAVVAVVAAGLWGEWAMDRLAEHWQWTSHWTEWFDAELVWGSPPQTFVSLIEYVVFAPIFEELAFRGLLFAILRRKFRFLPAALISAGIFGIAHGYGVLGLVSVCWSGVLWAWIYERTGSLLPGILAHAINNLLVCLAVMALLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5W2</accession>
    <name>A0A1W1I5W2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48380">
        <property type="protein sequence ID" value="SLM48380"/>
        <property type="gene ID" value="NSJP_2208"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2208"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="94" mass="11083" checksum="A6FB73A8DFF27E7E" modified="2017-06-07" version="1">MPNSFKRFGKRQPQKLSGTLFDAIVLSNLLMFSPLPCNTTVTPRMHYVTVLTFTIRRPHAHRDYHLPRRVFRFKSSDSGVHRDYVGCRTHLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5X8</accession>
    <name>A0A1W1I5X8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48417">
        <property type="protein sequence ID" value="SLM48417"/>
        <property type="gene ID" value="NSJP_2245"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2245"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="68" mass="7367" checksum="6D141C5B0607A91C" modified="2017-06-07" version="1">MLILAECARSGFIVKEDGSWNLAPGARELGRFLAIERQALQTLGLDRRAKPTGRSLAELLTAPTKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Z9</accession>
    <name>A0A1W1I5Z9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48405">
        <property type="protein sequence ID" value="SLM48405"/>
        <property type="gene ID" value="NSJP_2233"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2233"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="80" mass="8977" checksum="7EE83200C3FF52F0" modified="2017-06-07" version="1">MLVSRKGLHNFNGILHVVFVSYVEASNLSLRELSLIDSTDMVTVVNKGSSYRKHLFVVIDNGKVDWRLFHRVSSISEASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I603</accession>
    <name>A0A1W1I603_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48437">
        <property type="protein sequence ID" value="SLM48437"/>
        <property type="gene ID" value="NSJP_2265"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2265"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="59" mass="6435" checksum="A2EE3A2447B199B7" modified="2017-06-07" version="1">MIPFNHFIEHPPYVRGVLRVPAATVLAAARSQLYKPSGAGFYNNSGTDKVKLTCSRPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I650</accession>
    <name>A0A1W1I650_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2177"/>
    <dbReference type="EnsemblBacteria" id="SLM48349">
        <property type="protein sequence ID" value="SLM48349"/>
        <property type="gene ID" value="NSJP_2177"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2177"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="344" mass="36466" checksum="440A3C0C0C9B9754" modified="2017-06-07" version="1">MNKDQAVSPTILTPRQIAGHVVALLVGASLLALTFWLHTGSRAVPGLIRDLQSQDLQTEMLAAQGLSELKADAYPAASLLVDHALHHPNWSMRFAAASALRSIDLQAARQVMHDSLPGLGDSDAEVRRHTCALLGGLGLLAKPVVPALVKMLADEDDLTRERAIEALGAIGVPQADVSTALTTALFDRAPGVRHRAVSLFAFAVPIPTTALVPLAGLQKDPDKAVASLARIALDRGGGVHRTDVQMLMARLQRRNDREEALQRLARLGPPAAEAVPAIVPLLDDRLPLHRYLAVETLEAIGPGAAHVLPALRRLLDDPDPIVREAVAVALRSIESATPATGATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I691</accession>
    <name>A0A1W1I691_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48461">
        <property type="protein sequence ID" value="SLM48461"/>
        <property type="gene ID" value="NSJP_2289"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2289"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012664269" evidence="2">
        <location>
            <begin position="25"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="101" mass="10451" checksum="E231FE410BAE9254" modified="2017-06-07" version="1">MATRGFLVPIGVAIAAILPAKIHAAIPATEAPKSSDTSTSAALSDKSAALDPVVQEMKYVLGSEAHALLLRQSSAGALYAGHGSHVSHQSHRSHQSHRSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6A2</accession>
    <name>A0A1W1I6A2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Type IV pilus assembly protein PilP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2376"/>
    <dbReference type="EnsemblBacteria" id="SLM48548">
        <property type="protein sequence ID" value="SLM48548"/>
        <property type="gene ID" value="NSJP_2376"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2376"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007446">
        <property type="entry name" value="PilP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04351">
        <property type="entry name" value="PilP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="204" mass="21859" checksum="2C253275E69DE1E6" modified="2017-06-07" version="1">MKVMLVFQVTKATALLAGCCVIVLSGEIALSQPGLAINAKQVAPMRQDSVKMPSPADMGIRSTSDVVPSVSEGLAPQVDPQQPSVSLSVNGYDPSGRRDPFAPVLQQLVPGQIDLTVPPLQRIGLTDMNLIAVIWGAYGYTAMVQMPDGNGYAVRKGTRIGPNNGVVSAITEKGIVVQERFTDVYGRKQEREYVKLLHPKEGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6C7</accession>
    <name>A0A1W1I6C7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2221"/>
    <dbReference type="EnsemblBacteria" id="SLM48393">
        <property type="protein sequence ID" value="SLM48393"/>
        <property type="gene ID" value="NSJP_2221"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2221"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011473">
        <property type="entry name" value="DUF1579"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07617">
        <property type="entry name" value="DUF1579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013071458" evidence="2">
        <location>
            <begin position="23"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="195" mass="21932" checksum="6C2E0D9AAEF583BD" modified="2017-06-07" version="1">MQLKQLMLVGAGLMLSASLAVAEEQKQDMKAMMEKMEKAGAPGEQHKQLAKMEGKWETKTKSWMEPNTPPMETMGSCEHKMVMDGRFLKQKCMGDMMGKKFEGVGVTGYDNTSKKYTSTWMDNMSTSLHVMEGMAGDAKTINQQGETTCPIRGHMKLRSVMKIVDDNTHVFEMYGTDDKGGQEVKMMEITYTRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6D8</accession>
    <name>A0A1W1I6D8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48588">
        <property type="protein sequence ID" value="SLM48588"/>
        <property type="gene ID" value="NSJP_2416"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2416"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012099593" evidence="2">
        <location>
            <begin position="24"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="124" mass="13387" checksum="F4DF503B9C1F06F0" modified="2017-06-07" version="1">MMLRRGLAAILCTVFLGVTAAYADMGHGHAAAPLKAGAGSKAETHITEGIMHYEKGHMDEAKKHFTAAVQDDPQSAEAHYNVALVLDKTGDHKGASEHFKKAKELGKDNPDIQNSEILNKHVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6G7</accession>
    <name>A0A1W1I6G7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease accessory protein UreE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">ureE</name>
        <name evidence="8" type="ORF">NSJP_2393</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UreE family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2393"/>
    <dbReference type="EnsemblBacteria" id="SLM48565">
        <property type="protein sequence ID" value="SLM48565"/>
        <property type="gene ID" value="NSJP_2393"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2393"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00571">
        <property type="entry name" value="UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00822">
        <property type="entry name" value="UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012406">
        <property type="entry name" value="UreE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007864">
        <property type="entry name" value="UreE_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004029">
        <property type="entry name" value="UreE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036118">
        <property type="entry name" value="UreE_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05194">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02814">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036402">
        <property type="entry name" value="Ureas_acces_UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00988">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69287">
        <property type="entry name" value="SSF69287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0533">Nickel</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UreE_N" evidence="7">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="206" mass="22942" checksum="BCC6046106208A26" modified="2017-06-07" version="1">MLVIEAIIGNIHESAWSARLQHATLDWLALDQWEAQKSRLRKLSQNGVDVAISLPRGILLRDGDVLMWEESRQAAIVARVSLKDVMVVELTALQTHASDILIRTCVELGHALGNQHWPAVVKGDRIYVPLTVDQKVMASVMKTHAFRGITYHFVPGSEVIPYLAPHESRRLFGGAEGPVHSHEDGHDHSHDHAHPHGHGHPHDHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6L4</accession>
    <name>A0A1W1I6L4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48652">
        <property type="protein sequence ID" value="SLM48652"/>
        <property type="gene ID" value="NSJP_2480"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2480"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="229" mass="26536" checksum="7DAC00AE794B2E31" modified="2017-06-07" version="1">MRRRLEQRREAHRLPSLQRLKNRVHPVANREVVGDDFHERLAGIPIEYSLQRVHQIEQAHVVQRLFSRGPFFFLRRRSPGIDFPPHALLRVQLAGGILVALVFEQPPHEFLARIRPVILVLHGFVDRQQHLRLDLEQRGGHDQKLPRNGEIQLGHRFEVVEVLAGDQRDGNVIDIDLALLDEMQQKIERPLEILDANLVWELGLTGSFELVIHKPPYTSFGRLEQASAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Z8</accession>
    <name>A0A1W1I6Z8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2534"/>
    <dbReference type="EnsemblBacteria" id="SLM48701">
        <property type="protein sequence ID" value="SLM48701"/>
        <property type="gene ID" value="NSJP_2534"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2534"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="483" mass="55111" checksum="F1C5AF16EF88AAD7" modified="2017-06-07" version="1">MIDKEEMDSKSEELGVHVSNVQRDYVFGWLLSGLFQPGNPLGELLILKGGNAFRKAYFENARFSNDLDFSTEVELNEDLLRDGVAQACAHAKAGSGVEFFVDENRIGARSLAGEEIILYEVRVYFKSFYGEEDLTLKVKLDVQEFDRIFLPVQTRKLIHSYSDYAACQGHLRSLKLEELLASKLKALLQRQHSPDLYDFVYSIFFQKVLDVSRREIITTFLKRTIYEPTPHVARNMLLELPFQVLRGLWNQYLICPKISIVSFDDAESSFRSSVAEIFNIIAPGPRPAFATGGIQGVGRLSFYDRGYRETIMEAGRLRRLLKLVYDGYERLVEPYALSFKRRQDGIAREYFYAWDRSGGRSMQTGIKSFISDNVQSVQLTEQTFEPRFPIELAGGGGYFSTSSFSTDSGTHSSFGNTAPRSRTSSTSHFGRSRTKTTKAFGIMYTIQCPYCNKRFKRDKLDAKLNEHKDQYGNRCFGRLGFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I703</accession>
    <name>A0A1W1I703_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative DegP2 peptidase. Serine peptidase. MEROPS family S01B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48593">
        <property type="protein sequence ID" value="SLM48593"/>
        <property type="gene ID" value="NSJP_2421"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2421"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="284"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="396" mass="42549" checksum="F0C5C29FFB398336" modified="2017-06-07" version="1">MNRCDAMTGRAGSDMRRSALITMLSSILSIVLFVLACGPSPASALNTQEEINTVRVYKKISVATVLITSAYASTHHVNQEMGKGIGSGVLIDDQGLIVTNAHVVQGAAKLTVMLHDGTRLPAQMIGSDMVYDVALLRVAIPKGKYPHAQLGNSDKLEVGQKVIAIGHPFGLGYAMSTGIISGFGKLLETKQEVFQDRIIQTTTPINPGNSGGPLVDSDDRVIGINTAILLGAQNIGFAIPINTVKSVMADLQTYGRVIRPWLGVKGKFVTEELRTLIALPMVDGLLVQDVEEGSPAARIGLEAGELDVAIEGEPWVLGGDILVSINGQDLRTISHYTKTLQGLKADQAVELRVFRDGDYRTINLTLGERPMPPLPQQRPKTDVPPLIPQMLPYSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I749</accession>
    <name>A0A1W1I749_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48836">
        <property type="protein sequence ID" value="SLM48836"/>
        <property type="gene ID" value="NSJP_2669"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2669"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012777300" evidence="2">
        <location>
            <begin position="32"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="276" mass="29580" checksum="48108EB0CCACA331" modified="2017-06-07" version="1">MAARRAWSAAVVSSVAMLWCLAAPPSGVSLAADVSSATLSAHDVLVSPNLPAVVEAGLTVERRGKQLPAPGTSLELVQDMRVLATAVTDERGMAALRFVPTRRGSQQLIVRTLSGSAVTATAAVTVAVWERRTPILTVEAAALRDPVSGEPSPDAAEELRRMTQFYYNVVYVVAEAGDSGRRLAAGSRMRQWLADHGFPVGYVLVSASPEAFGPKLDELRSAGWTTIKVGVGRTKEFAEVFVQRRLEAVVVPEPAKGEAPRKAKVAKNWKDVRRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7M0</accession>
    <name>A0A1W1I7M0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49007">
        <property type="protein sequence ID" value="SLM49007"/>
        <property type="gene ID" value="NSJP_2840"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2840"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="82" mass="9718" checksum="D7EEE52968F736A3" modified="2017-06-07" version="1">MMERTMRANDRLMDLERTVSVLNGRLLNLQWELQRAKAYSLPERIWRNIVNGRQGNRFMSTVCSRHIRPNMKVRDYAGTTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7N1</accession>
    <name>A0A1W1I7N1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2828"/>
    <dbReference type="EnsemblBacteria" id="SLM48995">
        <property type="protein sequence ID" value="SLM48995"/>
        <property type="gene ID" value="NSJP_2828"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2828"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012867957" evidence="1">
        <location>
            <begin position="25"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="552" mass="61996" checksum="282CBBD04F6CEAD4" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7P0</accession>
    <name>A0A1W1I7P0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetoacetate metabolism regulatory protein AtoC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atoC</name>
        <name evidence="9" type="ORF">NSJP_2656</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2656"/>
    <dbReference type="EnsemblBacteria" id="SLM48823">
        <property type="protein sequence ID" value="SLM48823"/>
        <property type="gene ID" value="NSJP_2656"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2656"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="142"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="472" mass="53056" checksum="DF454E48B4C39116" modified="2017-06-07" version="1">MKKRVLLIDDESRVRASLKVILEPTYEVIQAADAQEGLDLYHKEAPHLILLDVILPGTDGLSVLQSLRSEDCPAPIIMLTGTKSVKTAVDAMKLGAADYLSKPFDAEELRIVVDRALNSKELEREVKSLRAQVTQRYAFHNLIGKSRPMQEIYTKIEQVADSRTTVLITGESGTGKELVAKALHFNSGRRDRPFVALNCAALPETLIESELFGHEKGSFTDATARRVGQFDLANSGTLFLDEIGDLSAMTQAKLLRVLQEREFTRIGGVQAIKVDVRIVAATNKNLEELVRKGLFREDLYYRINVIALYLPPLRDRGEDIPLLARHFLSKRIEEENRPHQEFSKDAVDLLTRYPWPGNVREMENIIEQAFIWSKGSDSVTLEHLPTIVRNDSRSSSLRDDTLAGRLSLEKAVAEFEREIILDALKKNNYIQTHAANQLGISRRMLKYRMDTLGIGRPDSENGGSETDPPVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7W1</accession>
    <name>A0A1W1I7W1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin--[biotin carboxyl-carrier protein] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2971</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2971"/>
    <dbReference type="EnsemblBacteria" id="SLM49138">
        <property type="protein sequence ID" value="SLM49138"/>
        <property type="gene ID" value="NSJP_2971"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2971"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="11"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="284" mass="30620" checksum="4B16B90F53AB6776" modified="2017-06-07" version="1">MTSPSPPLTRDDIRSVLATRALGARIELHRQVDSTNREAFALAQAGAEHGTVVVAEEQTLGRGRLGRTWYSPPGINLYCSVIVTASMPTTQFSQWLSWLPLATALGVAEAVEGAASLKTDLKWPNDLLVRERKLGGILCESGSTASSTPFQVIGIGLNVNGTDEDFPQDLRAASTTIRQETGRLIDRNHLLSRLLLEIEHCLNELTIEGNGRIAMAYTRRCITLGRHVRVSLAGGKAFTGIAQAIEPDGSLQVASLPRQRGGRPEVCSIRAADIIHVRPGEITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8B2</accession>
    <name>A0A1W1I8B2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49099">
        <property type="protein sequence ID" value="SLM49099"/>
        <property type="gene ID" value="NSJP_2932"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2932"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012190342" evidence="1">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="130" mass="14503" checksum="1EA7B200EDC1A08A" modified="2017-06-07" version="1">MKWRWSSLVITSLVLSACSAPPVCPDPGGIATRETCYYYETVANKKEAGNQVIGVVAKAVIEEDSKSLFNFYDLKDYRFNHHIFEVDQATFTDLVPGSSYMFIASPGDPVLKLCRTQECKLAVDKLNEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8E8</accession>
    <name>A0A1W1I8E8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2906"/>
    <dbReference type="EnsemblBacteria" id="SLM49073">
        <property type="protein sequence ID" value="SLM49073"/>
        <property type="gene ID" value="NSJP_2906"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2906"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="178" mass="20557" checksum="794F3C58D9CA1848" modified="2017-06-07" version="1">MNSEQSSPIGWKHKIIEEVIEYWIIFGYIALVLVAFTWYRRLILAQYHIEYTEYWFPLIEAAVLAKVIMVGDWLGLGRGLQHKPLVLSTLYKTFVFTLWVALFTLIEKTVRGLIHGHGVMGGIDEMASKGPYELLSWCIVAFLTFIPFFGFRELGRVLGMKRIRALFWKQSISAQAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8K9</accession>
    <name>A0A1W1I8K9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Muropeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ampG</name>
        <name evidence="6" type="ORF">NSJP_3190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49357">
        <property type="protein sequence ID" value="SLM49357"/>
        <property type="gene ID" value="NSJP_3190"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3190"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="PTHR12778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="420" mass="44226" checksum="4D63AD34B6C06F04" modified="2017-06-07" version="1">MNAFPVTQVLANRRIAFMLPLGFASGLPLALTSGTLQAWLTVVGLDLKTIGIFTLVGLPYTLKFLWAPLLDRITPPWLGRRRGWMLLTQIGVTLGLVAMAMTGAGGRAEWLGLTAVLVAFLSASLDIVFDAYRTDLLLPAERGFGAAVWVNGYRFALLIASSGALVLADHIGWQSTYLVLAGIMATGIVAVLAAPEPTFTGTPPMSLVEAVGDPLRELFSRSDILKLLFLILLYKLGDAVAASLQTAFFIGGLGFSTSDVGYVKGIGLFATLGGALAGGVAMARLGLVPSLVLFGLFQALSNLCFTGLAWAGKSYAALTASVLIENVTGGMGTAAFVALIMSLCDHRYTATQFALLSSLEAVGRVFSGRPSADLVGAVGWAQFFFISFLLALPGVWLAWTLRAKLQERPGPESVGECAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Z5</accession>
    <name>A0A1W1I8Z5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOSC domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3305"/>
    <dbReference type="EnsemblBacteria" id="SLM49472">
        <property type="protein sequence ID" value="SLM49472"/>
        <property type="gene ID" value="NSJP_3305"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3305"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="28"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="182" mass="20742" checksum="C8E247361A099C0C" modified="2017-06-07" version="1">MKLVSVQVGRPRTVRWRGKSITTGIYKKPVTGRIMARHFNLEGDQQADLTVHGGRDKAVYVYPSEHYAFWQKELPGTQLPYGSFGENFTTEGLDEQSVHIGDRFRIGGAVMEVTQPRLPCYKLGLRFRRPDMPKRFHVSGRCGFYLAVIEEGEVGAGDGWERLAHDDREMSVSESYRSVFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I926</accession>
    <name>A0A1W1I926_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation-transporting ATPase</fullName>
            <ecNumber evidence="7">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3335"/>
    <dbReference type="EnsemblBacteria" id="SLM49502">
        <property type="protein sequence ID" value="SLM49502"/>
        <property type="gene ID" value="NSJP_3335"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3335"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="853" mass="91407" checksum="DF335CBBD0EA20E1" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I939</accession>
    <name>A0A1W1I939_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49516">
        <property type="protein sequence ID" value="SLM49516"/>
        <property type="gene ID" value="NSJP_3349"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3349"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025515">
        <property type="entry name" value="DUF4403"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14356">
        <property type="entry name" value="DUF4403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="519" mass="56289" checksum="C1B894C073F36B14" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I986</accession>
    <name>A0A1W1I986_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gltA</name>
        <name evidence="8" type="ORF">NSJP_3431</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 7">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3431"/>
    <dbReference type="EnsemblBacteria" id="SLM49598">
        <property type="protein sequence ID" value="SLM49598"/>
        <property type="gene ID" value="NSJP_3431"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3431"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011278">
        <property type="entry name" value="2-MeCitrate/Citrate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01800">
        <property type="entry name" value="cit_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="378" mass="42150" checksum="98722D3B9E2AB6DF" modified="2017-06-07" version="1">MPHDFMPGLAGVPAAKSAISDVDGARGVLEYRGIRVEELCASSSYLETAYLLLFGHLPSRGELSKWTEDVTRHRRVKFTIIDLMKCLPEHGHPMDALQAAVAALGMFYPGRNVKDVENNYWSAVRLVAKLPTIVAAWARLRRGDEAIPPRDDLEFSENFLYMMTESVPPAVWSEVFDDCLILHAEHTMNASTFTGMITASTLADPYTVVASSIGSLKGPLHGGANEEVVQMLKEIGTPGHAREFVVQRLADKRKLMGFGHRVYKVKDPRAVILQSLSVKLFKACGSSPLYDVAVEVERAASEHLDAKGIYPNVDFYSGIIYDKMGIDVDLFTPLFAMARVSGWLAHWLEQLHENKLFRPDQIYSGEHNRSYVPLNERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I994</accession>
    <name>A0A1W1I994_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3417"/>
    <dbReference type="EnsemblBacteria" id="SLM49584">
        <property type="protein sequence ID" value="SLM49584"/>
        <property type="gene ID" value="NSJP_3417"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3417"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="267" mass="28547" checksum="44F4B8F83321BC23" modified="2017-06-07" version="1">MPSNQKLSASAMEIDRMALQLAKDPQSKVFLPLAEEYCKAGMWQEAAGVLEDGLKFYPGFITAMVVLGRAYDQLGQSTKAKALLEEAVRVSPENLRAHRTLIKIYVAQGASDEALRSCEVILALNPRDEEARAIREKLGKSSELTTRTPGHIRPVAPIVPTAVSTSPVSEEADRTETVDPRTPFQDLSAAATTTHEVADPVPAAAVDQAGQDGAAATPEPSPNSVDPVSAPSPHAGTVAQLEAWLRSIERARRDRNGSDRSGSLSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9F7</accession>
    <name>A0A1W1I9F7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49509">
        <property type="protein sequence ID" value="SLM49509"/>
        <property type="gene ID" value="NSJP_3342"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3342"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="101" mass="11271" checksum="8CE701A3DA136BA5" modified="2017-06-07" version="1">MRRLIYKPIEFQLEYSIFVVSLGGERCRKAQLGRLTQIGPNQPLGPTRLPRAATACSGRWRTASTRLATPRGNFFITSPVTERLLAGQWVSALPWSLASLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9I3</accession>
    <name>A0A1W1I9I3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49708">
        <property type="protein sequence ID" value="SLM49708"/>
        <property type="gene ID" value="NSJP_3541"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3541"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="125" mass="13972" checksum="43F33F08D207CF5E" modified="2017-06-07" version="1">MSMSLGIRPSKKRMPKDSCWRIESLMKPKGILTYFERKRCERGTRFGTCGGAVGYGPAHIVNMVCPDAGPILGIRLIEPLATIVKWDRLSACPLNSKSPSNRCSQHRYWCSRSPNTTVSMLISRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9J8</accession>
    <name>A0A1W1I9J8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49473">
        <property type="protein sequence ID" value="SLM49473"/>
        <property type="gene ID" value="NSJP_3306"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3306"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="71" mass="7993" checksum="E96AE8841C4D887A" modified="2017-06-07" version="1">MSDDAYDCRFDCWIVRLTSAMRSLYNQSKTDARTSLEQPCGVIGERIVTWIGWKPASSGNEECPATERCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9S4</accession>
    <name>A0A1W1I9S4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3630"/>
    <dbReference type="EnsemblBacteria" id="SLM49797">
        <property type="protein sequence ID" value="SLM49797"/>
        <property type="gene ID" value="NSJP_3630"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3630"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="307" mass="31501" checksum="38A04A98DE09D6F4" modified="2017-06-07" version="1">MKTLANMNVVSRKTQQGLVKKFTRPAQLVFVLGVGLNLLGCGDGGDGAVSAQQGTGTAFVAPTVFQAAGPTVASIQNTVDQYRTALGATNNGNTPGPLPTNSGHREINWDGGGVDTTTAPVTPFTTFLNTRGAQFTTPGTGLSQAPPSGGPQGGLATLFNNPSYGTIYNTFSPLRLFTPVDSNITEALFFVPGSNGTVPAKVSGFGIVFTDVDLPDGSGPSNTNGGRKASTQIECFGINGELLFSNVAPASPGDGNLSFIGIVFADARIAKVRITSGDAAPGPNDDGTHDIVMMDDVLYGEPQPIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9U3</accession>
    <name>A0A1W1I9U3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="3">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3598</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3598"/>
    <dbReference type="EnsemblBacteria" id="SLM49765">
        <property type="protein sequence ID" value="SLM49765"/>
        <property type="gene ID" value="NSJP_3598"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3598"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042518">
        <property type="entry name" value="SirC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="PTHR35330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="217" mass="24258" checksum="E564EC6008DC9FA7" modified="2017-06-07" version="1">MPANPGFPLSLDVRGYHVVVLGGDEEAAEKTQRLLDAGAKVTVVAPTLHDHLKQLAASAKVVHRGRHFRVSDMENTILILNMVRGDRDFARSLFAKAREKKVLLWSVDFPEASSAIMPAVVATGHMRIAISTSGMAPALSGFMKEDLERILDSEFSAFLDWLGELREQAKRDQPDVEKRRTMLREALDGFRLLGKVQYPKVWIDHRSQQKTESPAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Z9</accession>
    <name>A0A1W1I9Z9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4 11">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">hemB</name>
        <name evidence="13" type="ORF">NSJP_3574</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4 11"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3574"/>
    <dbReference type="EnsemblBacteria" id="SLM49741">
        <property type="protein sequence ID" value="SLM49741"/>
        <property type="gene ID" value="NSJP_3574"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3574"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM49741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="323" mass="35605" checksum="4A0EA8C63B55AB07" modified="2017-06-07" version="1">MAFPIQRLRRLRQRDGLRRMVRETSLSPSNLIYPMFIVEGQGRREEIASMPGQFRCSIDLLIKEAGEIFGLGIPAVILFGIPDRKDERGSSGFDPDGIVQRAVRAVKDKVPDLIVVTDVCIDEYTSHGHCGIVKDGRIVNDETLDCLRAMARTHAQAGADIVAPSDMMDGRVAAIRTELDAAGFPDTPIMAYAAKFASCFYAPFRDAAASSPQFGDRQSYQMDPANRREALREIALDIEEGADIVMVKPALPYLDIIAAARAFTDLPIAAYQVSGEYSMIKAAAKADWLDERRAMMESLLAIKRAGADLILTYFAKDAVRLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA69</accession>
    <name>A0A1W1IA69_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49779">
        <property type="protein sequence ID" value="SLM49779"/>
        <property type="gene ID" value="NSJP_3612"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3612"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="86" mass="9903" checksum="B8376548E26D0EB6" modified="2017-06-07" version="1">MDEEAIYKEVAHALELLGLTLPTTKEELERARQLQLSTWNPSRYANLTNNPKQYMKNYKRAEEMTKKIEAAYSLLSAVLVPEDESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA71</accession>
    <name>A0A1W1IA71_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction response regulator, receiver domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3496"/>
    <dbReference type="EnsemblBacteria" id="SLM49663">
        <property type="protein sequence ID" value="SLM49663"/>
        <property type="gene ID" value="NSJP_3496"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3496"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="122" mass="13505" checksum="C2D258598667D0D7" modified="2017-06-07" version="1">MADILLIDDEAATRQFFRRTLEGAGYAVNEVSSAREGLAHLQRHAVDLVITDILMPDMDILELTWMLHQKFPRVKVVAVSSGAHDTDHCNVARFFGAHETLSKPVAVPRLLETVGRLTDPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA89</accession>
    <name>A0A1W1IA89_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Phage integrase (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3749</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3749"/>
    <dbReference type="EnsemblBacteria" id="SLM49916">
        <property type="protein sequence ID" value="SLM49916"/>
        <property type="gene ID" value="NSJP_3749"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3749"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="216"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="450" mass="51364" checksum="EDB74B24EDEA0C78" modified="2017-06-07" version="1">MVVSREKLQKQVGNSPRLTRSLLRSIIGIRCLFLPLRSNAMNIRRIQSANGTRSVLTYWYRGKRYRPVLGRNLTTDQERESARTIINAIHDNCVEHEVRGSASSRSRESSASTFAEFVPMYLQYLQAKRPDNDGRNQTALTHHLVPHFGNKRLLDIRLEDGLAYLEKRRSDLIGPERNKRHVASGTIERECAALMAVLNLAVDMDHLDKNRLKRLPVPEYVKRERIVEAWELLKIRESASINIWRLVMAALQIGLRENKLIEIHEEWLLKRGDGWWIAPSPGRSKIKGVPKLIPLNGLAYESLFGNSPRIGGRFFSQWKDGNSIKHTWMRTCERAGVHDLHFHDLRHTFTTWLTQCGVDYAVIQTLKGEPLPGSAKYYIHDWNVRLRDAVTRLESFTKAVLSGENGIQVPLGATCLPPSYVEASPNPHEMVPRDRIELSTPAFSGLCSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAA5</accession>
    <name>A0A1W1IAA5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmid replication initiation factor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3758"/>
    <dbReference type="EnsemblBacteria" id="SLM49925">
        <property type="protein sequence ID" value="SLM49925"/>
        <property type="gene ID" value="NSJP_3758"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3758"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003916">
        <property type="term" value="F:DNA topoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003491">
        <property type="entry name" value="Rep_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02486">
        <property type="entry name" value="Rep_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="451" mass="50458" checksum="03C4A043ED8B06C6" modified="2017-06-07" version="1">MRMKALLNVKELASVLGVSVKSVQRAYRRREIPVHWLCRMALFDLDEVRRAMALNGSRRFDTSVGSHDKDGAAGGASRRRQPAARRVPKPPDGKTGAQFPEEDTEETMSWTCSLGWLRFTVPNASVEETMRLVGGDWVPDEKGFLGYGRGWMCRGSAGGLGRIGSGAKRAPLEVHVDLSQELLSGWTYDQFQAVAQWVFMKQGHFGRIDVALDDRSGVIDVEAVYDAVVAGQCVSHFRKSQLIEGLDVGSGEETGTTLCMGSRQSDTYLRIYDKAAQQQSKGIVVEGPWVRWEMEWKDERAQAVGLALSVLDQDRFQPYIVGVFRTAVDFRDCTREDDPKDRYHAPLLAWWKVLTEGMQRAKLDVVKAVKKIEDVKQWAAKSLAPMLGLLCVHPEAGERWLVSTIIEGVERWRPKHYAFLASGQDVQQVLKKVRWWKPTDGFAAGCASTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAD4</accession>
    <name>A0A1W1IAD4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49733">
        <property type="protein sequence ID" value="SLM49733"/>
        <property type="gene ID" value="NSJP_3566"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3566"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="61" mass="6909" checksum="D70E5742131B09A9" modified="2017-06-07" version="1">MPKLVRIVIQLPVELKAQLDALKQQGYTTSGFIRAMLERELTKPEDDASNVLPMVKKVNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAG9</accession>
    <name>A0A1W1IAG9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50014">
        <property type="protein sequence ID" value="SLM50014"/>
        <property type="gene ID" value="NSJP_3847"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3847"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="87" mass="9780" checksum="F07DF0E27F3422F6" modified="2017-06-07" version="1">MSRLSVSGRAPRSRGRGLTATQQRVPSRLAKRRLGDRLKEDTVLFNKGNLADKLRREGYEEVPLDELQDRLSKLQGPLAAVILKGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAH6</accession>
    <name>A0A1W1IAH6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3833"/>
    <dbReference type="EnsemblBacteria" id="SLM50000">
        <property type="protein sequence ID" value="SLM50000"/>
        <property type="gene ID" value="NSJP_3833"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3833"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="169" mass="18824" checksum="9C23BF94E237FDA0" modified="2017-06-07" version="1">MAQRVRLREPVRFSMIRRMGVGAYIQAWRLSRGHSIEALATEAQITSYTLEKIETEEVDPGTSTLEALAGALKIPAAWLFTHPTSFQHLFADDEGVEIPSGPDPVTERILTGSRMDRSLFILLTALIQSAEPKLLRAAEMSLRSLVKQSKQATVPWQNRPSGHFEPPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAR6</accession>
    <name>A0A1W1IAR6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3908</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3908"/>
    <dbReference type="EnsemblBacteria" id="SLM50075">
        <property type="protein sequence ID" value="SLM50075"/>
        <property type="gene ID" value="NSJP_3908"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3908"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1425"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM50075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1532" mass="164895" checksum="6C491A263D152DA1" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAR7</accession>
    <name>A0A1W1IAR7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3844"/>
    <dbReference type="EnsemblBacteria" id="SLM50011">
        <property type="protein sequence ID" value="SLM50011"/>
        <property type="gene ID" value="NSJP_3844"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3844"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="359" mass="39922" checksum="127C1DFA63DA0FA7" modified="2017-06-07" version="1">MPTRILLGTLVVLALLPVPSWARRESFTEQQKLQVKKIDRVLLEVIALTDKGPADPAPFLDLISKRLRELGYTVVADPAQPHDVLVQVKCEQRKTWEGTTKMGSDADLPDSPSRLWKGPACQLVYFLDGKKMGWHKEVRTEFADAEPAAVAAKAGDAGTYAMNHLRERLDDYDFPTLITAEWGQEERLFKLYDDPATPSARKIRLVNLFGYLFSNDAVPRLLAGLKGPDLEIAKASALALGNIGQKDTVPALVETMKTGRPELRPSAAKALGILGALHGDFTIVDPLLETLKSTDDVALKTEVVWALGKLPDRRAHEPLLALQKSLYNVRENDADPKMVKLKEAVNWTIKQIDTWEYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAV7</accession>
    <name>A0A1W1IAV7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_4001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4001"/>
    <dbReference type="EnsemblBacteria" id="SLM50168">
        <property type="protein sequence ID" value="SLM50168"/>
        <property type="gene ID" value="NSJP_4001"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4001"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="208" mass="23035" checksum="A7D5AD3F5D545408" modified="2017-06-07" version="1">MGRLFGDERGITYLFLMFAIVLIGIATTTAAKQWKGMIQREQEADLLTKGIEIQNALALYSATMKAGRVTQGEVYPQSLVELTRLPKPFLRKAYRDPMTHGEWEYLKGPYGGIMGVRSRSVAEPIRKHEFPLPVRHFDGKKSYRDWIFQFPNPSMAGAFPSTVPVNVPPPNAMNQFPTGSNQSNQANSQPSDSSGPSGNIMVPPASSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB90</accession>
    <name>A0A1W1IB90_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_4014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50181">
        <property type="protein sequence ID" value="SLM50181"/>
        <property type="gene ID" value="NSJP_4014"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4014"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012461458" evidence="2">
        <location>
            <begin position="31"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="297" mass="32658" checksum="EBB988DD516BFD79" modified="2017-06-07" version="1">MRMGGRRLGFVFNVGFLAGWLLFCAGQAQAAVFFDDSFEGATPEASGWGYAQGWCYYNAPRANPCPEIDLSTDVAYAGSKSLKGTYKAEWSDPNPQTHDQAISRKFTPTTDLYVRYYYRTSKFTYTAASGTKHLYYKNSPNTSPTFVSINWFGSRELGFAAQVIAEICPTSGSGPYSSCNYYPNVASVPLNDNVWYCIEEHIKMNTPGVDDGALEIWVNGVRTLGYYSERFRGSQVSGPSGNSSNTYIDILQIYKQNGDGLMYYDQFAVGNTRIGCTAGSSPQDSTPPASPTGLILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB95</accession>
    <name>A0A1W1IB95_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4141"/>
    <dbReference type="EnsemblBacteria" id="SLM50308">
        <property type="protein sequence ID" value="SLM50308"/>
        <property type="gene ID" value="NSJP_4141"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4141"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="58"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="204" mass="23749" checksum="DCFDE1003D882625" modified="2017-06-07" version="1">MTDDKADLQPIARLYEESLEQHGLKPLGVGWRDEDSHRLRFDKLASVIDAEGRSSINDLGCGYGALHDYLISRGIEVSLFRGYDISDKMLAQAKVRVPHGDFRKSSVLDETADYSFASGIFNVRLQEDEANWLGHIERTLDNLFQHSSRGFAFNLLSTYVDYREPQLYYGDPLYFFDYCKRRYSRRVSLLHDYPLFEWTITVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZQ9</accession>
    <name>A0A1W1HZQ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carboxy-terminal-processing protease</fullName>
            <ecNumber evidence="6">3.4.21.102</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ctpA</name>
        <name evidence="6" type="ORF">NSJP_0052</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.102" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0052"/>
    <dbReference type="EnsemblBacteria" id="SLM46224">
        <property type="protein sequence ID" value="SLM46224"/>
        <property type="gene ID" value="NSJP_0052"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0052"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="90"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="370"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="453" mass="49184" checksum="F89FB6EAD022E0F5" modified="2017-06-07" version="1">MERYPRRRFWMLSPVIGLALVFGVVIGKGWERTGHATETYEELKTFSEVLTQVQKNYVDETKVKDLVQGAIRGMLSTLDPHSAYMTPEMYKEMQVETKGEFGGVGIQIGVKENRLAVIAPIEGTPAFRAGIKAGDYITKVNDETTKDLTLMDAVQKMRGPKGSKVNLTIQRDGTTDPLQFTLVRDTIKIESVKSKVMDNIGYVRLTQFQEATGRDLSRVLKQFKEQKLQSTILDLRNNPGGLLTAAVEVSEQFLPNGKLVVYTKGRESKKDEWFAKGRDQMDDAPMIILVNEGSASASEIVAGALQDYGRAVIVGTTSFGKGSVQTILPLGDGSGLRLTTAKYYTPKGRSIQSTGITPDIVVKPQSPVTVAKADAKPGEKDADAKAKPGAAAGKEQPSTGAKPEEAATKNGSAPAAAPSADPSGDLAMDQDVQLQKAVEMLKTWKIFKELRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZZ8</accession>
    <name>A0A1W1HZZ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NSJP_0132</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0132"/>
    <dbReference type="EnsemblBacteria" id="SLM46304">
        <property type="protein sequence ID" value="SLM46304"/>
        <property type="gene ID" value="NSJP_0132"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0132"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="581"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM46304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="638" mass="71460" checksum="CE980D629894F719" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I011</accession>
    <name>A0A1W1I011_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">3-deoxy-D-manno-octulosonic acid transferase</fullName>
            <shortName evidence="9">Kdo transferase</shortName>
            <ecNumber evidence="3 9">2.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 9">Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">waaA</name>
        <name evidence="11" type="ORF">NSJP_0011</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) = alpha-Kdo-(2-&gt;6)-lipid IVA + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28066"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58603"/>
            <dbReference type="ChEBI" id="CHEBI:60364"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:85987"/>
            <dbReference type="EC" id="2.4.99.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Bacterial outer membrane biogenesis; LPS core biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.12" evidence="3 9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0011"/>
    <dbReference type="EnsemblBacteria" id="SLM46183">
        <property type="protein sequence ID" value="SLM46183"/>
        <property type="gene ID" value="NSJP_0011"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0011"/>
    <dbReference type="UniPathway" id="UPA00958"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043842">
        <property type="term" value="F:Kdo transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009244">
        <property type="term" value="P:lipopolysaccharide core region biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007507">
        <property type="entry name" value="Glycos_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038107">
        <property type="entry name" value="Glycos_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039901">
        <property type="entry name" value="Kdotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42755">
        <property type="entry name" value="PTHR42755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04413">
        <property type="entry name" value="Glycos_transf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_N" evidence="10">
        <location>
            <begin position="30"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR639901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR639901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM46183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="446" mass="49489" checksum="31060454224CF8E0" modified="2017-06-07" version="1">MWYFLYNAVLLLATPVILCLLLAKKRCRRGLPQRFGFARPPIRPDERPLVWIHAVSLGEVVAVTPLVKELHRRHPDYRFAVSTVTETGREAVEQRLRGVAEHCYAPLDFPWVVSCMIRHLRPVLYLFVETELWPNLLRSLHRSGIPTVLVNGRLSSRSFARQQWEPVRSFYRSMLETLSLCLMQSDRDAERIIALGADAKVVKRTGNIKFDQPAPESVDSRSVRSSLGLRDGEQLIVAGSTHPGEEEALVDAYRSLAEHHPSLLLLLAPRHIERAEQVEAMVRARGVSVRRRTAMKADRNETWSGPRVILLDSRGELATLYREAVVAFVGGTLVPVGGHNLLEPALWGKPVLFGPYTDHCAEIAGFLLQAGGGVRVTGEELAKRIGELLDRPDEGARIGVAARSVVEQNRGALKATVDAVDDVLRAAVGTRRPAPAPDSLPLMAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0F5</accession>
    <name>A0A1W1I0F5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type transport system, ATP-binding component</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_0161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0161"/>
    <dbReference type="EnsemblBacteria" id="SLM46333">
        <property type="protein sequence ID" value="SLM46333"/>
        <property type="gene ID" value="NSJP_0161"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0161"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="244" mass="27487" checksum="7422F618BFF149EE" modified="2017-06-07" version="1">MMTPPVLSVTKLRKQFGEFTAVQDISFVMKPGEILGLLGPNGAGKTTTMQMLLGLITPTSGSIQMFGLELASHREEILQQVNFSSTYISMPLALTVEENLWVVARLYGLTDIERRVDDIVKKLEMEEIRRKVARKLSSGQMTRLTLAKAFLTEPKILFLDEPTASLDPDIAHKIRALLKEERRSSGLSILYTSHNMREMEDMSDRIIFLQRGTIVAEGTAREIVARFGEADLEEVFLKIARESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0K6</accession>
    <name>A0A1W1I0K6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46528">
        <property type="protein sequence ID" value="SLM46528"/>
        <property type="gene ID" value="NSJP_0356"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0356"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="263" mass="27513" checksum="D6D9B05C1395552D" modified="2017-06-07" version="1">MKPKSHRGWWVIAAMLVAGCTGNEPVIGPSSAGVESRGAPQMPRPIKPGMAAAPGAPTPQKFQLPSWPQKWDVNNREPHGVAFGVTQPGPVTVDVQSQGAPVVVALVGAGPQSVQQQLGSGSIRLTHQVTPADVQRSAIWKVGIALAQPGGPSAQAAGTIAVQSPPADMNTLRSQIQAQNTPHPPLDPQSAARAKAATDASFQAELAKFKQEQTARRAAIAAGLQSLPQMQAARARLQGQVKSRTIESGDAEERIFAPREVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0L4</accession>
    <name>A0A1W1I0L4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46538">
        <property type="protein sequence ID" value="SLM46538"/>
        <property type="gene ID" value="NSJP_0366"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0366"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011831940" evidence="2">
        <location>
            <begin position="26"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="536" mass="59544" checksum="616B5D0FD85E6786" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I141</accession>
    <name>A0A1W1I141_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46553">
        <property type="protein sequence ID" value="SLM46553"/>
        <property type="gene ID" value="NSJP_0381"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0381"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012370779" evidence="1">
        <location>
            <begin position="22"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="172" mass="18699" checksum="7769D2469CBB7950" modified="2017-06-07" version="1">MHYLVLLSAIVWSFTSGVAHGASSIQRESLRDLPGVTVVVEEVPSDAQAEGLSEELIRAAAERSLQSRGTRILTPVEQASSPSKPSLYVRVGTYRIQSNQYVYVVTVALKQSVVLAHRPQRKMFASTWEQGVIGTPGANSLGEATKVVEDLVSAFANDFQAVNNQDAVREEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I170</accession>
    <name>A0A1W1I170_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 2-succinylbenzoate--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.26" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0559"/>
    <dbReference type="EnsemblBacteria" id="SLM46731">
        <property type="protein sequence ID" value="SLM46731"/>
        <property type="gene ID" value="NSJP_0559"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0559"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008756">
        <property type="term" value="F:o-succinylbenzoate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="50"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="471"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="574" mass="65500" checksum="3A08EC9270BE43A1" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1K0</accession>
    <name>A0A1W1I1K0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46867">
        <property type="protein sequence ID" value="SLM46867"/>
        <property type="gene ID" value="NSJP_0695"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0695"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="94" mass="10309" checksum="7FFF587EDA08D260" modified="2017-06-07" version="1">MSDCTAPPHAGRSFNEVGGPVYPESHPIDKGFGKVLSPFLPIPQPSVFRYGIGNSRHVWETDPPEAKKSGEKRKIMYPQLSKASRGLPSGPFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1K7</accession>
    <name>A0A1W1I1K7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Penicillin-binding protein 1A</fullName>
            <ecNumber evidence="4">2.4.1.129</ecNumber>
            <ecNumber evidence="3">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">mrcA</name>
        <name evidence="17" type="ORF">NSJP_0577</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="4"/>
    <dbReference type="EC" id="3.4.16.4" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0577"/>
    <dbReference type="EnsemblBacteria" id="SLM46749">
        <property type="protein sequence ID" value="SLM46749"/>
        <property type="gene ID" value="NSJP_0577"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0577"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031376">
        <property type="entry name" value="PCB_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17092">
        <property type="entry name" value="PCB_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="S1" evidence="16">
        <location>
            <begin position="363"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="752"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SLM46749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="797" mass="87963" checksum="0260EC76E274FEA1" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1W7</accession>
    <name>A0A1W1I1W7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Peptidase</fullName>
            <ecNumber evidence="2">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0826"/>
    <dbReference type="EnsemblBacteria" id="SLM46998">
        <property type="protein sequence ID" value="SLM46998"/>
        <property type="gene ID" value="NSJP_0826"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0826"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="53"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="254" mass="28243" checksum="A19AAC45C676A3F4" modified="2017-06-07" version="1">MSGILDRFFVFHPDPWDDRDWQQRSGIPLEDVWFSSADGTKLFGWYVEGFADRPVILWCHGNAGNVINRLDNLARLFRSAFSVFVFDYRGYGRSQGRPSEEGLYLDAIGAYDYLTRTRMIRPERLILFGRSLGAAVAGDLAAQNPAAGLVLESSFPSIEAVAKVHYGGLPLHWLLGAEFRLIDRLPSLSLPKLIIHGDRDDIIPLALGRQVFDGSLPPKSFYVIPGAGHNNTYVVGGSAYFSRFAEFALSAVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1X7</accession>
    <name>A0A1W1I1X7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47008">
        <property type="protein sequence ID" value="SLM47008"/>
        <property type="gene ID" value="NSJP_0836"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0836"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="55" mass="6002" checksum="87D1F63F097A6777" modified="2017-06-07" version="1">MDTLRVGIGVSDNDPLMTGPDVPVRCGGIVFLVRRVDCQILWNTEQGVKPTCAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I240</accession>
    <name>A0A1W1I240_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="8">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 14" type="primary">leuS</name>
        <name evidence="14" type="ORF">NSJP_0869</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0869"/>
    <dbReference type="EnsemblBacteria" id="SLM47041">
        <property type="protein sequence ID" value="SLM47041"/>
        <property type="gene ID" value="NSJP_0869"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0869"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="12">
        <location>
            <begin position="41"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="13">
        <location>
            <begin position="221"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="422"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="666"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="585"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM47041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="811" mass="91699" checksum="833B0CB789D2ACDE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I292</accession>
    <name>A0A1W1I292_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase or fumarate reductase, flavoprotein subunit</fullName>
            <ecNumber evidence="6">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_0943</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0943"/>
    <dbReference type="EnsemblBacteria" id="SLM47115">
        <property type="protein sequence ID" value="SLM47115"/>
        <property type="gene ID" value="NSJP_0943"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0943"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01811">
        <property type="entry name" value="sdhA_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="37"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="5">
        <location>
            <begin position="503"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="637" mass="70749" checksum="7FB866DC4E9D0399" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2A7</accession>
    <name>A0A1W1I2A7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system protein E (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0966"/>
    <dbReference type="EnsemblBacteria" id="SLM47138">
        <property type="protein sequence ID" value="SLM47138"/>
        <property type="gene ID" value="NSJP_0966"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0966"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="587" mass="65898" checksum="177C3D0B07F1E9BA" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2B5</accession>
    <name>A0A1W1I2B5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxyacid dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0965"/>
    <dbReference type="EnsemblBacteria" id="SLM47137">
        <property type="protein sequence ID" value="SLM47137"/>
        <property type="gene ID" value="NSJP_0965"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0965"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="166"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="296" mass="31100" checksum="EACA195EC1D2ED9D" modified="2017-06-07" version="1">MTPPGTVALLGTGLLGGAIAERLHHSGLSVIAYNRTASKTRALRSQGLVIAEHPEDAVAQAEGILLVLTDAAAIGSILLNPPCAQRLSGKTVIQMGTIGPDESLTLQRDLRVCGADYCEAPVLGSLAEAKAGTLLVMVGATVGQFEAWRPVWNALSRHPRLIGPVGRAAALKLALNQLIAAQIAAFSLSLGAVQRSGIAPDTFMAILRESALFAPAFDKKLPRLLARQYDNPNFSVAHLLKDLRLFGRLAAGLHLQSESADGVGRLLEATIAKGLQDVDYSALFDVINPPDTTGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2D7</accession>
    <name>A0A1W1I2D7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="5">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NSJP_0811</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Fe(III)-[cytochrome c] + H2O + nitric oxide = Fe(II)-[cytochrome c] + 2 H(+) + nitrite</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0811"/>
    <dbReference type="EnsemblBacteria" id="SLM46983">
        <property type="protein sequence ID" value="SLM46983"/>
        <property type="gene ID" value="NSJP_0811"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0811"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="52"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM46983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="324" mass="35596" checksum="76012D75A8B76C30" modified="2017-06-07" version="1">MSDTRFRGPSFRQGQGLSSVTSLLAWSAVGLFCAQTSDAGEVAVQLRASVTKIEVAKDDQREAWTFNDTFPGPVIRIKEGDVVDFTLKNEADRVHSIDFHAAKTPWNLHFQGVPTGSESSFRWKADYPGEFYYHCGTDPMIQHIANGMFGAVIVEPRTPVVKADREYVIVQSEIYPTPHDVDTMMAGKPKLVVFNGRANKYLDEPLRAKPGELIRLHVVNAGPNHFSAFHVIGAVFDRVYASGNPKNIEHGIQTYTLPPGGGATFDLVLPEEGMYPMVTHSLQDALTGALGLIHVSNEETSKTSFEALPPPQDRDVAWTGAADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2H2</accession>
    <name>A0A1W1I2H2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0897"/>
    <dbReference type="EnsemblBacteria" id="SLM47069">
        <property type="protein sequence ID" value="SLM47069"/>
        <property type="gene ID" value="NSJP_0897"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0897"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="260" mass="28797" checksum="83CD71EE038F69B6" modified="2017-06-07" version="1">MKSSTASSVRCSVCAAVQKAFSPVCRTCGKVLAASRLSTASPRGGQRTSQGRPGEDLVARAYKWLLETDQDEGRLAFIWRTVVWLVLLRWSWLFMAAPWGSNAAGESFLHLVNLPFHEAGHLLFMPFGRFMMFLGGTLGQVLMPVICLGTFLMKTHDPFGAAVALWWTGENLLDIAPYIDDARSLDLVLLGGVTGRDTDGHDWENILGMLGWLEYDHRLAHLVNNAGILMMLAALLWSGALLLRHFRRCRMSRNEPAPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2K1</accession>
    <name>A0A1W1I2K1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Peptidylprolyl isomerase, PpiC-type</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0927"/>
    <dbReference type="EnsemblBacteria" id="SLM47099">
        <property type="protein sequence ID" value="SLM47099"/>
        <property type="gene ID" value="NSJP_0927"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0927"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="2">
        <location>
            <begin position="152"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="300" mass="33983" checksum="BDC8BCCDD3E4B6FB" modified="2017-06-07" version="1">MVSRPFRSASPSGSAADRRIRLACSALLLLLAGCTPPSSEERIVAFVNGRPISQVEFENEWNELPDATRTRYEKEGGKPRLLSEVITRELLLQEARRQGLDQNDQIRDRARRYKERLMLDELLKDRIKTKIELTKEELDAYYDKHARQLLTPLKVRVAVMLLPNYPAAKDLEKQVNQGGDFGKFAQRYSIDAKTKANGGDLGPYRKDLVAPEVDEAIHQLKPGMTSAPIKTDAGYYLVRITALDPEIIQADLATRERLRQELLNEKRQKRFDDVIADIRAKAVVKIADVSRFGAGDLANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2N4</accession>
    <name>A0A1W1I2N4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47254">
        <property type="protein sequence ID" value="SLM47254"/>
        <property type="gene ID" value="NSJP_1082"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1082"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="94" mass="9986" checksum="68280CB15686AC42" modified="2017-06-07" version="1">MFAVLLLSIPYLVDVAYYGDLTPTHSAQIVDSHGEEALSVDEAVSSDDSTKDSPVINGGSVDVIAPSYSGHDWKNDPRSQFLAVASHASRSPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2R1</accession>
    <name>A0A1W1I2R1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47261">
        <property type="protein sequence ID" value="SLM47261"/>
        <property type="gene ID" value="NSJP_1089"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1089"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="112" mass="12405" checksum="7E42C5BCB33D1AB6" modified="2017-06-07" version="1">MTDQKSILIACALASTGFLWGCETTTSSTGGGGPSQQEAARAVVDYRRLAAELREMAHRRELEADVLAKQQNPDQAMIAHWREMAQHLRAEADTAEQHAQEMQRSVPHGMMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Y2</accession>
    <name>A0A1W1I2Y2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Quercetin 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_1011</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.24" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1011"/>
    <dbReference type="EnsemblBacteria" id="SLM47183">
        <property type="protein sequence ID" value="SLM47183"/>
        <property type="gene ID" value="NSJP_1011"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1011"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008127">
        <property type="term" value="F:quercetin 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041602">
        <property type="entry name" value="Quercetinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="PTHR43212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17954">
        <property type="entry name" value="Pirin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C_2" evidence="4">
        <location>
            <begin position="157"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="249" mass="27523" checksum="CBC30176716E647C" modified="2017-06-07" version="1">MMEVRKTVTPSVDIRRAADRFHTRISWLDSWHSFSFSTHYDPANTHHGLLLVSNDDRVSAGTGFHTHPHQNMEIVTWVLDGELEHKDSEGHKGIIYPGLAQRMSAGTGIWHSEMNPQKQKDVHFIQMWVVPDTTGLAPGYEQLDINDQLAKGGLVPIASGRGHDAAIRIHQKGAVLWGGRLKPGETVEVPDGLYSHIYVARGAAQLEKAEPLHTGDAVRLTAAGARKLRADDTIGTEVLVWQMDAPADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I311</accession>
    <name>A0A1W1I311_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1097"/>
    <dbReference type="EnsemblBacteria" id="SLM47269">
        <property type="protein sequence ID" value="SLM47269"/>
        <property type="gene ID" value="NSJP_1097"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1097"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021309">
        <property type="entry name" value="DUF2892"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11127">
        <property type="entry name" value="DUF2892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="72" mass="7393" checksum="1ABCC3B8D6B34D37" modified="2017-06-07" version="1">MPCNVGTVERSIRILLGVLLLGIGAFAELSPVETGAALVVGTIALVTGAVRFCPLWAVLGFNTCATNPTAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3I7</accession>
    <name>A0A1W1I3I7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47554">
        <property type="protein sequence ID" value="SLM47554"/>
        <property type="gene ID" value="NSJP_1382"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1382"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="78" mass="8616" checksum="81EFD7EEE6FCD847" modified="2017-06-07" version="1">MLREWIIFALCLGVGGHVALGVMLHAPNLWPWSTAGFYGLLSGLLIYAVVQGGRLVWRMARRTSVSPSDKSKADPFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3N8</accession>
    <name>A0A1W1I3N8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47618">
        <property type="protein sequence ID" value="SLM47618"/>
        <property type="gene ID" value="NSJP_1446"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1446"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="100" mass="10710" checksum="0B631BA80AB20A01" modified="2017-06-07" version="1">MGGRTSKGGLLVEESSAAALTLVRSIPIARMPLRGAAKRNEEGFTPLAGRAHFRKEVGSSVILSPLIAPRAPPSFFFVVTLVKCANIRTSQQAFMKLQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3N9</accession>
    <name>A0A1W1I3N9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative chromosome-partitioning protein ParB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">parB</name>
        <name evidence="4" type="ORF">NSJP_1413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1413"/>
    <dbReference type="EnsemblBacteria" id="SLM47585">
        <property type="protein sequence ID" value="SLM47585"/>
        <property type="gene ID" value="NSJP_1413"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1413"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="3">
        <location>
            <begin position="29"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="282" mass="31410" checksum="FDFF2DA4E09429F2" modified="2017-06-07" version="1">MEKKALGRGLEALLPSNKPVSVPDAADLQHLRVDAIVPNRYQPRQTFSPEELDELAASLKQSGLLQPILVRRKGDGMYELISGERRWRASKAAGLETIQAVVRNCSDEESMVLALVENLQREDLNPLEMAKAYHRMVVEFGLTQEVIAQRVGCERSSIANIVRLLNLPQEVQQLIETDQLSLGHAKVILGLSSPAEQQRIAQLIAARGLSVRETEKLVESALGEKKRKIKEVRRSPLSDVEHRLEKRLGTKVTIANGKRGGKIVIHYFSPAELDGILENILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3V1</accession>
    <name>A0A1W1I3V1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DZANK-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1525"/>
    <dbReference type="EnsemblBacteria" id="SLM47697">
        <property type="protein sequence ID" value="SLM47697"/>
        <property type="gene ID" value="NSJP_1525"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1525"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024399">
        <property type="entry name" value="DUF2628"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10947">
        <property type="entry name" value="DUF2628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="DZANK-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="214" mass="24303" checksum="ECD76C158A2F31EB" modified="2017-06-07" version="1">MQPCPQCTQQNQDDSKYCYQCGANLSSAVETQPAFSSAEGTTLTDVELWKAFIGPHADRYVEQFKKFGSAQAPQFALTWNWPAFLFISFLWFLYRKMYLYAMVYAIGPMVSTYLTGDVTVGIVWSIMAGATGNYVYYWHCREQIGEIKRKSGEDPAKREQAIRETGGVQSYVVWVGVAFYVLFLLVMFKMAQEELSDKDRQPVKPAKPAALIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I422</accession>
    <name>A0A1W1I422_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1447"/>
    <dbReference type="EnsemblBacteria" id="SLM47619">
        <property type="protein sequence ID" value="SLM47619"/>
        <property type="gene ID" value="NSJP_1447"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1447"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011986333" description="Ysc84 domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Ysc84" evidence="2">
        <location>
            <begin position="103"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="189" mass="19922" checksum="CFDE7176E8337171" modified="2017-06-07" version="1">MREPVSRGLQLVAMVAGSALLLNAWLAGPASAASAKEIDAGADEAIVKFEQEVKGGKAFIESSKGMLVFPKVIKGGAGFGGEYGEGAFRVKSKTVDYYSMLQGSFGLQLGGEIKTIYLVFLDEAAMKKFHDGEGWKAGVDGSVSLVTLGAGGTIDTNNMKDPIVAFVLGQKGLMYNLSLEGTKFTKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I490</accession>
    <name>A0A1W1I490_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47761">
        <property type="protein sequence ID" value="SLM47761"/>
        <property type="gene ID" value="NSJP_1589"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1589"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="71" mass="7928" checksum="0791E5E728B3B820" modified="2017-06-07" version="1">MSRPVGGVEQPAYQGSANRILRPNPLIGWTFFRGFQNKDINEPIRLAILISIGSGTAIIKRDTSPLLLHWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4A1</accession>
    <name>A0A1W1I4A1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Disulfide oxidoreductase dsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1658"/>
    <dbReference type="EnsemblBacteria" id="SLM47830">
        <property type="protein sequence ID" value="SLM47830"/>
        <property type="gene ID" value="NSJP_1658"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1658"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012551623" evidence="1">
        <location>
            <begin position="31"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="2">
        <location>
            <begin position="53"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="218" mass="24055" checksum="CBD082DC1731FCAC" modified="2017-06-07" version="1">MVTRFRRSWGIALSVCVVAAGLAWGTVTTAAAPEQKGKFELLSGEASTHKPGKVKLIEFADFYCPHCHHFDEAGLPILQKEFGNKLEATMVGFPVFRNKLPTPFDMYEQAKIMGKGDEMKRVLFRTIHTDKITGVLDRSLREGLIKEVGLDPKAFEEGLASGKPAKAFEDGKQWGERIKVQSTPTLLLDGNIKIEGDNLKTDNIIAVIRGILDADAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4E6</accession>
    <name>A0A1W1I4E6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47811">
        <property type="protein sequence ID" value="SLM47811"/>
        <property type="gene ID" value="NSJP_1639"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1639"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="75" mass="8652" checksum="12C5280BA36928E6" modified="2017-06-07" version="1">MILSVLVNERDRRPLDQWGCYSRIQHMAGRAHPGAECRGVSRFLMVRVLGLVGNRLGRCKRAYSKNAEDQEPRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4F9</accession>
    <name>A0A1W1I4F9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="2">DAP decarboxylase</shortName>
            <shortName evidence="2">DAPDC</shortName>
            <ecNumber evidence="2 3">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">lysA</name>
        <name evidence="6" type="ORF">NSJP_1531</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="2 3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1531"/>
    <dbReference type="EnsemblBacteria" id="SLM47703">
        <property type="protein sequence ID" value="SLM47703"/>
        <property type="gene ID" value="NSJP_1531"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1531"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="29"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="36"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="273"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="420" mass="45499" checksum="C6A8F528D9B079C2" modified="2017-06-07" version="1">MHSFEYRHGELYCEQVPVSRIAKEVGTPCYVYSHATLTRHFRAYDGAFKDIPHVVAFAMKANSNLAILRLMAKEGSGVDIVSGGELFRALKAGVPPSKIVFAGVGKSADEIRDALKAGILMFNVESSAELRAIDGVAASVGKKARVALRINPDIDPKTHPYISTGLKKSKFGIAADRALEEYKLASSLDHIEIVGVHAHIGSQLTEVTPFVEALKKVVALVESLKAQGIGIQYLNVGGGLGITYSDEKPPLPKDLAEAIFPLVKDRNLTLVMEPGRVIVGNAGILVTRALYQKDGEAKRFVIVDAAMNDLIRPSLYSAYHDIRPVSESLLARPKHSVDVVGPVCESGDFLAKDRTLPEVKPGDLLAVMSAGAYGFVMASNYNSRPRVPEVLVKDADIHVIRARETYEDLVKGETIPSFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4I2</accession>
    <name>A0A1W1I4I2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47912">
        <property type="protein sequence ID" value="SLM47912"/>
        <property type="gene ID" value="NSJP_1740"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1740"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="67" mass="7058" checksum="F3FB90404D7C0E2F" modified="2017-06-07" version="1">MGRADVFEKTSGLIGKGLLGAHEPSGHHRAGVRLLAGRRPAFFRHAAACRQPGACDRCAGCGCRVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4S8</accession>
    <name>A0A1W1I4S8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0111 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1828"/>
    <dbReference type="EnsemblBacteria" id="SLM48000">
        <property type="protein sequence ID" value="SLM48000"/>
        <property type="gene ID" value="NSJP_1828"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1828"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="205" mass="23087" checksum="5573DAC98A7A288F" modified="2017-06-07" version="1">MFGLIPREEAFFELFKKAAHNMIEGSRLLAAMMKDLRSPVDQAKRIKEVEHVGDSITHEIALRLNQTFITPIDREDIHDLASALDDILDVAEAIADRFVLYKVTKPTDMAVKLADILYQASVAVGQGVDRLGMAHPEIKECSVQVNSLENEADRVSRDAISELFDKETDPIAVIKWKEIYEGFEAGTDRCEDVANILERISLKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4T4</accession>
    <name>A0A1W1I4T4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48037">
        <property type="protein sequence ID" value="SLM48037"/>
        <property type="gene ID" value="NSJP_1865"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1865"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012438732" evidence="2">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="66" mass="7033" checksum="8538EAA4A36FE6A7" modified="2017-06-07" version="1">MKIRIGVGMVILVLMALPAFAQVFPVDATSTTTITSVKADLIAWGVAFIGVALTVFAYKRVKALVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4U3</accession>
    <name>A0A1W1I4U3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1671"/>
    <dbReference type="EnsemblBacteria" id="SLM47843">
        <property type="protein sequence ID" value="SLM47843"/>
        <property type="gene ID" value="NSJP_1671"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1671"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012099601" evidence="1">
        <location>
            <begin position="29"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="52"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="686" mass="75926" checksum="C7FB31027490ED06" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4V1</accession>
    <name>A0A1W1I4V1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NSJP_1854</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1854"/>
    <dbReference type="EnsemblBacteria" id="SLM48026">
        <property type="protein sequence ID" value="SLM48026"/>
        <property type="gene ID" value="NSJP_1854"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1854"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="549"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="589"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM48026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="617" mass="68406" checksum="A653CE03ADB75C61" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Z5</accession>
    <name>A0A1W1I4Z5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoglutarate:ferredoxin oxidoredutase beta subunit</fullName>
            <ecNumber evidence="2">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">forB</name>
        <name evidence="2" type="ORF">NSJP_1787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.3" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1787"/>
    <dbReference type="EnsemblBacteria" id="SLM47959">
        <property type="protein sequence ID" value="SLM47959"/>
        <property type="gene ID" value="NSJP_1787"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1787"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="92"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="300" mass="32959" checksum="1ADB3A0611D31287" modified="2017-06-07" version="1">MSLDYVKFSNGFEKFMPKEYRDMVEHGPFGKKISVSQMGSFKEVLEEHPMCAGCAMTLFIRLAMIAFPNPEDTITVGTAGCGRLAISQAAIPFVYGNYGDQNGVASGLSRGLRLRFGDKPKDVVVMAGDGGTADIGFQQVLHSWFRKERFTTIMLDNEVYGNTGGQESGMTNRGAVLKMAPLGKKFEKMDMVQMAKVAGCAYVATVVPNNPRRVESVIKKAVLIAREVGSTYIQAYTSCNIEYAIPTDKVMEDAKTVENDRYAFSEYVSDEAKQYLTERYGYKEFLAKPAAPAGAIPSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I518</accession>
    <name>A0A1W1I518_9BACT</name>
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        <submittedName>
            <fullName evidence="8">Transcriptional regulatory protein ZraR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">zraR</name>
        <name evidence="8" type="ORF">NSJP_1751</name>
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    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Nitrospirales</taxon>
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            <taxon>Nitrospira</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1751"/>
    <dbReference type="EnsemblBacteria" id="SLM47923">
        <property type="protein sequence ID" value="SLM47923"/>
        <property type="gene ID" value="NSJP_1751"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1751"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="142"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="461" mass="51066" checksum="7C2FB1D5D8F59FA5" modified="2017-06-07" version="1">MEKILVVDDEKSLREVMSIMLKRAGYAVTEAADGEEAIGQVNKDIFDLVITDLRMPKAGGMDVLKAVKSSSPDTVVLVVTAFATADSAVEAMKQGAYDYLTKPFQVDEVQLIIRNALEKRRLSTENMLLKREMASQSSFAQIVGQSEAMQKVFDVVRKVADAKSNVLICGESGTGKELVARAIHYNSARSTMPFVAVNCSAVPETLLESELFGHMKGSFTGAVANKAGLFEVANGGTIFLDEIGDTTPAIQVKLLRVIQEREFRRVGGNQDMKVDVRIIAATNRDLEKAVADGSFREDLYYRLDVIPIRLPPLRLRTGDIPLLVKHFLEKFAQDSGKAAPVLTPEAMHVLLGHEWRGNVRELENLIERVVAFAAGGPVREHDIRGWLHHSVTSQAQQGIPADLPEDGLDLEGLINGIEKDLLMKALERTRWVKKKAARLLRLNTRSFRYRLEKYAIKGGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I593</accession>
    <name>A0A1W1I593_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator in two-component regulatory system with PhoR (Or CreC)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">phoB</name>
        <name evidence="6" type="ORF">NSJP_1831</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1831"/>
    <dbReference type="EnsemblBacteria" id="SLM48003">
        <property type="protein sequence ID" value="SLM48003"/>
        <property type="gene ID" value="NSJP_1831"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1831"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="135"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="135"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="233" mass="26357" checksum="45FEAFBE89EC965C" modified="2017-06-07" version="1">MAQTAPRKILIVEDEKDILQLVKLYLDKEGFRTVTAATGTDGLKSVKQDKPDLVVLDLMLPEIDGLEVCKQLRSAPETAMVPIIMLTAKAEESDTVIGLELGADDYVTKPFSPKALVARVKALFRRLDRSQNQHVTVYRYGDVVMDLARHEVTDDEKEVPLTAKEFGLLEHLLRNPGRVLTREVLLNTVWGYDYFGTTRTVDVHIRRLKQKIPLLDEAILSVKSLGYKLREED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I595</accession>
    <name>A0A1W1I595_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">rpmE</name>
        <name evidence="8" type="ORF">NSJP_2000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2000"/>
    <dbReference type="EnsemblBacteria" id="SLM48172">
        <property type="protein sequence ID" value="SLM48172"/>
        <property type="gene ID" value="NSJP_2000"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2000"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="68" mass="7734" checksum="6BAB8E2652D6CA76" modified="2017-06-07" version="1">MKKGIHPLYREATVHCACGNKYKTRSTVGDINVDICSNCHPFFTGTQKIVDTEGRVERFKKKYAKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I599</accession>
    <name>A0A1W1I599_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48101">
        <property type="protein sequence ID" value="SLM48101"/>
        <property type="gene ID" value="NSJP_1929"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1929"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="175" mass="19660" checksum="03560334D7292780" modified="2017-06-07" version="1">MGFLTQMQFSWNKVTKLQKLEKAIAPPHEPVSRIVADLMGANERDGSTEKKRALEEFLDLCDSNRGVRSVMEHEHLSRVDLRGIAVYLMARGLGQWVKGHCVALSTISHVEPLHYFVLAERHGVDRQHILAHLLQYWEGKISSSELQEHLPVTSSPDATASEPPHAVLHVCEEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5C5</accession>
    <name>A0A1W1I5C5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48089">
        <property type="protein sequence ID" value="SLM48089"/>
        <property type="gene ID" value="NSJP_1917"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1917"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="153"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="252"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="350" mass="37422" checksum="7DEC5C216F940A53" modified="2017-06-07" version="1">MHPMSKHGQYVGLPYLGKASTRAPGMGRFSPLFILVLTLLQGGCGTIVSRNVDPYQDRGSQEGDLVYPRTRIYGGVAADIHWIRYEYRSKTTSNIPLPLDIPLSFAADTVLLPLTVYEQFFIGALPVAAEKGDLTAVKLMLEKGENVESRDSWGHSALMSAAWAGHDEIVQVLLENGGAINGKTRQGLTPLFYAVLNGHTATARRLLDQGADPNSLWSGETTPLMVAAGKGNKELVDALIAKGADVNARGMFQFTPLIHAAMEGHTETVQVLLTNGAIVNAKDNAGGTALIHAACEGREETVVLLLQNGADVNAKRFTKPAHPSNSALGCAIHNKHAAIAERLKQEGATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5C8</accession>
    <name>A0A1W1I5C8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ilvH</name>
        <name evidence="10" type="ORF">NSJP_2013</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2013"/>
    <dbReference type="EnsemblBacteria" id="SLM48185">
        <property type="protein sequence ID" value="SLM48185"/>
        <property type="gene ID" value="NSJP_2013"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2013"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM48185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="172" mass="18962" checksum="519FFE3C99A06B4E" modified="2017-06-07" version="1">MEHIISVTVENKFGVLSRIAGLFSGRGFNIESLSVAPTLDPSMSQMTIVTSGDERIVEQIVKQLNKLIDVIKVVDLNESDFVSRETALIKVHTRQEDRAEALRIADIFRANVIDSTPSTYTIEVTGDPAKIEAIINLLQPLGIKELTRTGRVAVAREPLRSAAVQPKKIARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5D8</accession>
    <name>A0A1W1I5D8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmid replication initiation factor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1871"/>
    <dbReference type="EnsemblBacteria" id="SLM48043">
        <property type="protein sequence ID" value="SLM48043"/>
        <property type="gene ID" value="NSJP_1871"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1871"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003916">
        <property type="term" value="F:DNA topoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003491">
        <property type="entry name" value="Rep_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02486">
        <property type="entry name" value="Rep_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="344" mass="38478" checksum="F339590F55911EF1" modified="2017-06-07" version="1">MSWTCSLGWLRFTVPQATVEEAMTLVGGDWVADEKGFLGYGRSWICRGQTGGYGRIGTGAKRAPQEVHVDLSQELLSGWTYEQFQAVAQWVFAKDGHFGRLDVALDDRSGIIEVEAVYAAVVAGHCVSHFRKSQLIAGLDLGSGADTGKTLCMGSRHSDTYVRIYDKAAQQQSKGIVVEGPWVRWEMEWKDERAQAVGLALSVLDQDRFQSYIVGVFRTALDFRDCTREDDPKDRYHAPLLSWWKTLTEGMQRAKLEVVKAVKQIEDVKQWAAKSLSPMLGLLCVHPEAGERWLVSIIIEGVERWRAKHYALLAKGQDAQQVLKRVRWWKPTDGFAAGCASTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5K2</accession>
    <name>A0A1W1I5K2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2126"/>
    <dbReference type="EnsemblBacteria" id="SLM48298">
        <property type="protein sequence ID" value="SLM48298"/>
        <property type="gene ID" value="NSJP_2126"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2126"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045330">
        <property type="term" value="F:aspartyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pectinesterase" evidence="2">
        <location>
            <begin position="41"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="3">
        <location>
            <begin position="116"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="348" mass="37126" checksum="66BB41E9DAA79365" modified="2017-06-07" version="1">MGAPVRPYPMRIIAFMIVFLAVAGVSSAERSPDTGQGIRTIVVALDGSGDFTSIQEAVDSAKKGDTVFLKPGAYRQDVTVHSKERVKLVGAGRDQVVLLGREDIVGVLHVGKWPYGATDVEISDMTINEHGGHAVGLFNGRGVTLKRLTVNGMLFSQQVQDARIEDCTIGGSETTGVQFADTQAVLVANFIHDNDHGVNVAGKSDVRIERNVITRSLFEAVVVNDKAKAVVISNTLVKNGGGAAFLGQSQSEATGNVVGLNRIGFLIAPSSRVHASYNSLYNAEHDYMQAGNPNHPAPELKAQSDIMGDPYFVDPGRDDFRLRGDTPLLRVGTFPFLGALPPASKSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5S3</accession>
    <name>A0A1W1I5S3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48340">
        <property type="protein sequence ID" value="SLM48340"/>
        <property type="gene ID" value="NSJP_2168"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2168"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="225" mass="25428" checksum="8667B10A48D44C4B" modified="2017-06-07" version="1">MVAVTEGEFVMGADGTQALEDERPAHRPWLAAFSIDVHEVTTAHYAEFLKASGRPAPWQWETVELSRHGDRPVIGVDWADADAYCRWRGKRLPTEAEWEKAARGTDGRLYPWGNQGPVPDLANFALGARFSYSQVLMPVHSYERGKSPFGALQMAGNVYEWVQDWYGANYYELSSDRNPTGPDQGQFKVLRGGSWSDLPKYLLTYGRFKLPPETRNSYTGFRCAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5T4</accession>
    <name>A0A1W1I5T4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Coproporphyrinogen III oxidase</fullName>
            <ecNumber evidence="6">1.3.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemY</name>
        <name evidence="8" type="ORF">NSJP_2194</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:43436"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="1.3.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.15" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2194"/>
    <dbReference type="EnsemblBacteria" id="SLM48366">
        <property type="protein sequence ID" value="SLM48366"/>
        <property type="gene ID" value="NSJP_2194"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2194"/>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="7">
        <location>
            <begin position="14"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="485" mass="52341" checksum="0AE29C3C53A8975C" modified="2017-06-07" version="1">MTALKTVAIVGGGISGLATAFSILERSQQAGIPVVCTVLERSSSWGGKIVTHRVGELVTEAGPDSFLSQKPAGLQLIDKLGLTDQIIDTNKTTTKACVYSQGRLRELPEGLVVITPGQVGPFLRSGLLSPAGLLRMGMDMILPAGRSKEDESLASFFRRRFGRQAFERMMEPLMAGIYAGDAEQLSIKATFPRFPDLERTHGSVIRGMLATRAEATVSRANGRTRTMFVSLKNGLEDLVAALRRSLTDRGVMLRSGTSVESLRVRSHELGRWTYDVMLSGGSALSVDGLVLATPAFVSADLLRPLTPLAGGLLEQIPYASTVTVAMAYPASAVGPGVQGFGFVVPRVEQRDLIAATWTSLKWPHRAPSDQVLVRCYLGGVGRESVLELDDASLVTRVRAELQRICGLAAEPTYVEVNRWTKAMPQYVLGHLERLDEIERALSRFGGLVLTGSAYRGVGIPDCIRAGAIAADRVVRHLAGERVREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5V0</accession>
    <name>A0A1W1I5V0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">GAR transformylase</fullName>
            <shortName evidence="3">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purN</name>
        <name evidence="5" type="ORF">NSJP_2202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2202"/>
    <dbReference type="EnsemblBacteria" id="SLM48374">
        <property type="protein sequence ID" value="SLM48374"/>
        <property type="gene ID" value="NSJP_2202"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2202"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="4">
        <location>
            <begin position="10"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="3">
        <location>
            <begin position="19"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="10-formyltetrahydrofolate binding" evidence="3">
        <location>
            <begin position="101"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="3">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="224" mass="24323" checksum="F3B25C5A6413996B" modified="2017-06-07" version="1">MPTKRAAPLRVAVLASGRGSNLQAVIDAIEAGRVEATIVAVISNKKDALALERARKHGLPDVFVDPKPFAGRPDSRVAYDHALLDVLRRHDVELVLLAGYMKIITAVLIDAYANRMMNIHPSLLPSFPGLDVQKKAIDWGCKLAGCTVHFVTEGVDEGPIILQAAVPVLDGDTPDTLAARILEQEHRIYPRAVELFAEGRLRVEGRRVFIDGGKPVGDAILCPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Y6</accession>
    <name>A0A1W1I5Y6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Outer membrane protein and related peptidoglycan-associated (Lipo)protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_2071</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48243">
        <property type="protein sequence ID" value="SLM48243"/>
        <property type="gene ID" value="NSJP_2071"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2071"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012890388" evidence="3">
        <location>
            <begin position="22"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="210"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="325" mass="35269" checksum="A4B30AB4EDAC3370" modified="2017-06-07" version="1">MKRVACAIVLLAVGLGQPASARDVTGSQDHPMLTRYPQSVIKWYDTQSFMPYKIGVAKVGGYRKINDWVETAGKVTRIYYELSGERTHADVYSNYKKALNDAGFKLMADGFQAGQSVSPEIGSRNWLTIYYAANTLPPGAGVELLHGTATSGGSAFLAGQKTQAGTTVYVAIAITQQRADRVTYLIDVIEAGEAETGLVTIDADAMGKDIDQYGKVALYGLYFDHDQAVLKQESKPALAEIAKLLKVRPKLNVYVVGHTDSTGAFSHNLKLSQDRSRAIVDALVKEHGIASIRLEPHGVASLVPVAANRSDGERAKNRRVELVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I641</accession>
    <name>A0A1W1I641_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48293">
        <property type="protein sequence ID" value="SLM48293"/>
        <property type="gene ID" value="NSJP_2121"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2121"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017601">
        <property type="entry name" value="DGQHR-contain_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017642">
        <property type="entry name" value="DNA_S_mod_DndB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14072">
        <property type="entry name" value="DndB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03187">
        <property type="entry name" value="DGQHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="370" mass="43243" checksum="1E74B17866BF437E" modified="2017-06-07" version="1">MLATRIRQKEGMFYFIGYNAADLLAKVQFTSRYYFEGEELSEARLSEHDDVAQFIAGIERSEKGFQRLLNRQKIKQIVNFYETVVAQPMIPGTVLLFTDETLRFQRAGEHESIGHLSEPRGKYLIIDGQHRLAGLHFFQQRHPDQIDKVEVPCVLFDGRTAEFATEMFVIINSTHTRINRSHLVDLYEKVSWESPEKKFSAKVVNLLYGESDSPLQYKINRLGGRSKQEKWILQSEIFNELLKVVTAHKRWIESHLGMKPERCYALVRDYLKGVKDVMQDVWGQNERYMFTRDVTLKALIRVLDDIVVDRKLINDWESERSAKPFADLVRPWAALGKEFRAEGFYERFPAKGQLERVRKIHQRLLDAIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I643</accession>
    <name>A0A1W1I643_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2239"/>
    <dbReference type="EnsemblBacteria" id="SLM48411">
        <property type="protein sequence ID" value="SLM48411"/>
        <property type="gene ID" value="NSJP_2239"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2239"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="273" mass="30643" checksum="958E557131B5BA1C" modified="2017-06-07" version="1">MRRHSKRSTRQDKNRLLGWVYGGIGVVIICGIITAAVLLNLHRKETDPVTGCPKDGYESITSVLVDLTDPINPVQEAALQNALLKVRDEVPKYGRLEIYPLKPTITTAIEPLFFGCSPGSGRDEDNGFYGNPELANRRWKRMFADKVDAVINELQKLPPQQNSPLLEGLQSVAVTSLGSPLAANASTKRILLLSDMIHHTPELSMYKGAPDFVQFKSTQYYPRIKPTLRGAQVDVFLIVRDTQKHVQQPPLYKFWVEFMNASGGFLQNWEPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6J0</accession>
    <name>A0A1W1I6J0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48595">
        <property type="protein sequence ID" value="SLM48595"/>
        <property type="gene ID" value="NSJP_2423"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2423"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="168" mass="18696" checksum="922603543F9839D1" modified="2017-06-07" version="1">MTNIGIKRLRGLFMIRSGTERSSSAADRACSKLMMGVVILVTVMGCVSTETRERRALSEEFDRWLGQYKDTRIIEIGQPDRCVGQGGGSEICEWRVDGNALWYLYDADGIARRWKYTDRRFGEMKGAQDPSAAAGQTHESEADVAWKAVKDTFDDMQFMPGLGALGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6K1</accession>
    <name>A0A1W1I6K1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48637">
        <property type="protein sequence ID" value="SLM48637"/>
        <property type="gene ID" value="NSJP_2465"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2465"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="136" mass="14307" checksum="64CA1D115C2A30E8" modified="2017-06-07" version="1">MRAALTIILTGLLLIGFETRPMTTGANLLDRGLSSWDLFLVVIPLALIGLVWTKWTWPGMACVIYGTVGLALDLASLTGAAGESQPRLTPLNWLSGGFNLALTVAGWHAFVRSLWGDGPPTPLPPNPPAPSSSSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6N7</accession>
    <name>A0A1W1I6N7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2504"/>
    <dbReference type="EnsemblBacteria" id="SLM48676">
        <property type="protein sequence ID" value="SLM48676"/>
        <property type="gene ID" value="NSJP_2504"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2504"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013207074" evidence="2">
        <location>
            <begin position="28"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="485" mass="54683" checksum="2F5BDDC4F5EF0A7F" modified="2017-06-07" version="1">MRCGFARLTSSLLLLPLLLHCPVPADAQDPPSKRGAGPALKAPTSQVSIQGDYWALIIGINNYQGPPKLKTAVADATGLRDVLVDRYGFKADHVKLLLNEQATRTHIEGAFIRLAREAAPTDSVLVYYAGHGQYSDDNQLAWWVPVDGSMDEPGTWVLDAAIRNYIAAMRAQHVYIIADSCFSGNLFAQNRSVAPTVTDRYYAKLHAKRSRWGLTSGSTEPVADQGKDGHSVFAYHLIKFLKENEEPYLVPSRIADHVIPLVARNAEQMPRSQPLQGANDEGGQFVFQLASAARGFEDQARKAEELTKQQRDKAQEDFKKELDRLAEERRQVELDAKIKLEKERAHLQELERQLDLQRREEAEVKRRLEEEHRQRVEAERRATDALHSGETAEQAARQKAADDLRQAEATAKRKLAEEKQQREALERTLAEQRQREADTRRALEQEQTRRREAERIAKETPAKGAPPEPDVKQKQADRAPFVGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6S7</accession>
    <name>A0A1W1I6S7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2571"/>
    <dbReference type="EnsemblBacteria" id="SLM48738">
        <property type="protein sequence ID" value="SLM48738"/>
        <property type="gene ID" value="NSJP_2571"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2571"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="11"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="336" mass="36268" checksum="842BE334B9596C02" modified="2017-06-07" version="1">MNAPRHFGLDRHVGKTPLIRLRRLSELTGCEILGKAEFMNPGGSVKDRAALGIIEDAEARGVLQPGGTIVEGTAGNTGIGLTVIGHAKGYQSVIVIPETQSPEKIHLLRALGAEVLPVPEKPYSNPGNYNHVARRMAEEKGWFWANQFDNTANRLIHYRTTGPEIWEQTDGKVSAFVSAVGTGGTLGGTTLYLKERNPKVFVGCADPYGAAMWSWFTNGNTETNDGDSFAEGIGQGRVTKNLEGIAVDGAWRIPDQDALTILYQLLREEGLFLGLSSGINVAGALRLALERGPGQTIVTILCDSGAKYQSRIFNPEWLTANGLKTDMPLETLLSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7A4</accession>
    <name>A0A1W1I7A4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-secreting ATPase</fullName>
            <ecNumber evidence="3">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">xcpR</name>
        <name evidence="5" type="ORF">NSJP_2735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2735"/>
    <dbReference type="EnsemblBacteria" id="SLM48902">
        <property type="protein sequence ID" value="SLM48902"/>
        <property type="gene ID" value="NSJP_2735"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2735"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013369">
        <property type="entry name" value="T2SS_GspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02533">
        <property type="entry name" value="type_II_gspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T2SP_E" evidence="4">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="576" mass="63529" checksum="0F199F8257DF127F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7C5</accession>
    <name>A0A1W1I7C5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pstA</name>
        <name evidence="8" type="ORF">NSJP_2718</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2718"/>
    <dbReference type="EnsemblBacteria" id="SLM48885">
        <property type="protein sequence ID" value="SLM48885"/>
        <property type="gene ID" value="NSJP_2718"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2718"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="82"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="314" mass="34223" checksum="0855273D1304CF3C" modified="2017-06-07" version="1">MSLENAIAKPISSGFDRKQLVRRKRMDAVFARTGFLVTLAVLSVLLALIGQLAAEGVGRLSWQFLTSYPSRFAAQAGILSAWIGTILVMLLTALVAVPVGLGAAVYLEEYAPKNRLTTLIDINIANLAGVPSIVYGLMALALFVYEFRLGQSFLTAGLTLALLVLPMVIIAAREAIRAVPPQIREAAYALGATKWQTVQHHVLPCSMGGIMTGLILALSRAVGETAPLITVGALSFIAFLPHPPWQDEPPYVSFQWMFDPFTVMPIQMFNWVSRPQEDFHVNAAAAGLVLLVMTLAMNALAIAVRAHFRKRIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7D3</accession>
    <name>A0A1W1I7D3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_2737</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2737"/>
    <dbReference type="EnsemblBacteria" id="SLM48904">
        <property type="protein sequence ID" value="SLM48904"/>
        <property type="gene ID" value="NSJP_2737"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2737"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024961">
        <property type="entry name" value="T2SS_GspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11356">
        <property type="entry name" value="T2SSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="T2SSC" evidence="5">
        <location>
            <begin position="18"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="226"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="288" mass="30999" checksum="D18E92C534355D12" modified="2017-06-07" version="1">MSVRRTLIGLYLIGASFLIAHTINAVVAEALLVPAGVTAPRTADAVDPSTNQSAASLAYQVRTSGLFPLPPDPVATSPDGTPVAAVIQQPLNLATKLKLLGVVIGDQGGVSAIVEMIASKQQLFFRLHDHVPDVGEVAEIRRDGVLIRQGGQQEFLGLSMGDDQPPMMPRPQATPTAAVPGAPIKKTLDRREVDQAIGDLPKLLSQARAVPVMANGAMSGFRMDYIAPSSFYEKIGLHQGDVLKQVNGVEIRDPSTMLTLFQQLRNERTVKLDVLRNNQRATLLYDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7G7</accession>
    <name>A0A1W1I7G7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_2795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2795"/>
    <dbReference type="EnsemblBacteria" id="SLM48962">
        <property type="protein sequence ID" value="SLM48962"/>
        <property type="gene ID" value="NSJP_2795"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2795"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="128" mass="13973" checksum="1BE3BCA3B51D8B15" modified="2017-06-07" version="1">MPPFPQAYAQQTYALMRIVTGFLFLWHGTQKLFGVPMPPPQVPSFVIAVAGPIELIGGTLVMIGLFTRWAAFLCSGLMAFAYWMVHGFQAPLPIQNMGELAALYCFVFLYISAHGSGIWSVDAARSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7H1</accession>
    <name>A0A1W1I7H1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_2783</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48950">
        <property type="protein sequence ID" value="SLM48950"/>
        <property type="gene ID" value="NSJP_2783"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2783"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="28"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="478" mass="52052" checksum="764157C27737B9CA" modified="2017-06-07" version="1">MPAEPAPLSTNIPQRLDRLPWSRWHWLVVTALGVTWLLDGLEVSIVASLGPMLMSATTLYLTESQVGLTASAYLFGSVLGALLFAYLTDRQGRKKWFMITLTLYLGATVLTALSWNLPSFMVFRFLTGAAIGGEYAAINSAIDELIPAARRGHTDLAINGSWWLGSAGGALLTLVFLDPALFPEYLGWRLCFLFGGVIGVGVALVRRMIPESPRWLMTHGRVPEAESVVSGIEKQVAQERGPLADPQGTLTVHPRPHATPATVARELFGTYPKRTTLGIALMVTQSFMYNAVSFTYPLLLTKHYAVPANRVGWYVLPFALGNFLGPLLLGRFFDTIGRKPMITMTYAVAGVLLALTGYWFEQGAFTLSTHMLVWSLIFFFASAGASAAYLTVSEIFPMEIRAMAIAFFFMIAQGAGVLAPWMYGKMIESSVTSVYYGYLLGAGMMLAGAAAELWLGVAAEGRPLEELAAPLSSRTTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7L6</accession>
    <name>A0A1W1I7L6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Thiamine biosynthesis protein ThiS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2817"/>
    <dbReference type="EnsemblBacteria" id="SLM48984">
        <property type="protein sequence ID" value="SLM48984"/>
        <property type="gene ID" value="NSJP_2817"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2817"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="66" mass="7354" checksum="79639B9A0E784A1D" modified="2017-06-07" version="1">MIITVNGKSEVVQAFALLDLLNVKKIEPQMVAVELNDRMVERNSLATTPLKEGDRVEFLFYMGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7P3</accession>
    <name>A0A1W1I7P3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2859"/>
    <dbReference type="EnsemblBacteria" id="SLM49026">
        <property type="protein sequence ID" value="SLM49026"/>
        <property type="gene ID" value="NSJP_2859"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2859"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="399" mass="45002" checksum="6FCBC41593A71FE4" modified="2017-06-07" version="1">MPRVESSSPDSCPPYTLFDDGPAYRIEEKLGLLQDGRRRMGRRVLFALLVAWLPMLLLAAVQGLAMGPTRLESFLMDFIINVRFLITVPVLLVGESICEEQLRTVVRQFLDAHLVKVEIRARFDAIVRKAVDVSRSGLTDGLLVGVAYLHSLAAVIVYLYGLHHPTWRAPSIDGHITLSLAGYWYILVAFPLYAFLLWRWLFRIGMWWWFLRQVSKLNVQITPSHRDGVGGLGFLSDSVQAFVPFAFAEGALVAGTMADFVMYEGDSPFQYQWHVVGFVVIILILIVGPLWVFMRPLYKAKEEAAFRYGALASRQIQLVEERWIHAAPKREDLDASMPDFRSVTHLGHSVAAVRNMSIFPLQKDDVIKLIVMALLPLLPVAVTQIPMGEVFSLLLKVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Q1</accession>
    <name>A0A1W1I7Q1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">atpG</name>
        <name evidence="10" type="ORF">NSJP_2863</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2863"/>
    <dbReference type="EnsemblBacteria" id="SLM49030">
        <property type="protein sequence ID" value="SLM49030"/>
        <property type="gene ID" value="NSJP_2863"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2863"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM49030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="298" mass="33727" checksum="4A845975EAE99DF2" modified="2017-06-07" version="1">MPSLQSVRRKIDSVKKTQKITKAMKMVAAAKLKRTQERILAARPYALKMRDAIRTLSRRVNRDAHPLLKKREGHRIEVAVVTSDRGLCGAFNANILRTAAAALKEFESAGAKVQVIVIGRKGRDFFRRRGWTVRREIVDVFDKLSFEHGMLLGNELQALENYSANRIDAVYAIYNEFKSAIQQRVVVERLLPLDWVVEISDLKEADRGTEQVPGGYLYEPSEDELLEQLLHRNFHIQAYRMLLESSAAEQGARMAAMDGATRNAGELIKKLTVYYNKTRQAAITKELMDIVGGAEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Q2</accession>
    <name>A0A1W1I7Q2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two component transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49015">
        <property type="protein sequence ID" value="SLM49015"/>
        <property type="gene ID" value="NSJP_2848"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2848"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="16"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="148" mass="15987" checksum="F255F28D7E8261A7" modified="2017-06-07" version="1">MALLPQHANTENTSPRIVLAEDNPAMLDMVSRVLEPEFQIVGTVDNGRDLIQAAAELHPDVLIVDISMPTLNGLEAARQLAGERTAAKIVILTVHEEREFVEESLVAGAVGYVVKPRLATDLPVAVREALMGRTFVSPMRPSSHVGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7R7</accession>
    <name>A0A1W1I7R7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Haemagg_act domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2931"/>
    <dbReference type="EnsemblBacteria" id="SLM49098">
        <property type="protein sequence ID" value="SLM49098"/>
        <property type="gene ID" value="NSJP_2931"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2931"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008638">
        <property type="entry name" value="Filamn_hemagglutn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05860">
        <property type="entry name" value="Haemagg_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00912">
        <property type="entry name" value="Haemagg_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01901">
        <property type="entry name" value="adhes_NPXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Haemagg_act" evidence="1">
        <location>
            <begin position="45"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1301" mass="129327" checksum="2164A3EDAE782325" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7T1</accession>
    <name>A0A1W1I7T1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2900"/>
    <dbReference type="EnsemblBacteria" id="SLM49067">
        <property type="protein sequence ID" value="SLM49067"/>
        <property type="gene ID" value="NSJP_2900"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2900"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012461430" evidence="2">
        <location>
            <begin position="23"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="197" mass="22328" checksum="CFD7BFFA43F45791" modified="2017-06-07" version="1">MKFQFWTAIIGLILFMSCAGYAADKDITVVRVTPALDMDQIRYILSHEREQVFERGMVLNEKQWDKFWRVYDEYEKERQKLDAKRLRLLGTFINKHGTMSNEEATKLVDASRKNQQADLALRQKYFKILSKKLNPVAAARFVQLDDVVGMVVRLSILGNVPLITGTAEAVAEPESSPQTGERQPGPSEQSSPAAPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7T9</accession>
    <name>A0A1W1I7T9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2903"/>
    <dbReference type="EnsemblBacteria" id="SLM49070">
        <property type="protein sequence ID" value="SLM49070"/>
        <property type="gene ID" value="NSJP_2903"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2903"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022016">
        <property type="entry name" value="DUF3597"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12200">
        <property type="entry name" value="DUF3597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3597" evidence="2">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="131" mass="13946" checksum="EFB9246B31F6094D" modified="2017-06-07" version="1">MGLLSTILEKLGLGHSTAQAGQQTAPQTSSASSVPPKTVPPKSMTVVDIVAKLEGMAATHKEKLNWKTSIVDLLKLLGIDSSLTARKELATELGCPQEKMGDSAQMNMWLHKTVLKKLADNGGNIPKELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7X5</accession>
    <name>A0A1W1I7X5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pgi</name>
        <name evidence="9" type="ORF">NSJP_2854</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2854"/>
    <dbReference type="EnsemblBacteria" id="SLM49021">
        <property type="protein sequence ID" value="SLM49021"/>
        <property type="gene ID" value="NSJP_2854"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2854"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="546" mass="60314" checksum="5B8D4741EA72A8B0" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Y1</accession>
    <name>A0A1W1I7Y1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49104">
        <property type="protein sequence ID" value="SLM49104"/>
        <property type="gene ID" value="NSJP_2937"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2937"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="55" mass="6260" checksum="F79EF1D48A250862" modified="2017-06-07" version="1">MVFDHLPRCPEGQQALNPFGFSNASEAIQRMEMSDSAYKLFRISSGECAHQTIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I851</accession>
    <name>A0A1W1I851_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cysteine synthase A, O-acetylserine sulfhydrolase A subunit</fullName>
            <ecNumber evidence="6">2.5.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cysK</name>
        <name evidence="6" type="ORF">NSJP_2816</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2816"/>
    <dbReference type="EnsemblBacteria" id="SLM48983">
        <property type="protein sequence ID" value="SLM48983"/>
        <property type="gene ID" value="NSJP_2816"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2816"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="5">
        <location>
            <begin position="11"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="3">
        <location>
            <begin position="180"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="309" mass="32901" checksum="B83414AEDFD99853" modified="2017-06-07" version="1">MSAILHRDSTELIGKTPLVRLNRLSPEGGADIYAKVEFVNPGGSVKDRICLNMINEAERSGRLKPGDTIVEPTSGNTGIGLALIAAVRGYKLILVMPETMSLERASLLTSYGAELVQTAGWEGMRGSIREAERLVARQASSFMPDQFSNPANPAIHRTTTAPEIWEALNGTFDAFVAGVGTGGTITGCGEVFKERNPAIKIVAVEPASSAVLSGKICGPHKIQGIGAGFVPTVLNQTILNRIITVTDDQAYQTSKLLAKREGLLAGISSGANVFAAQQIARELGPGKRVVTMLCDTGERYISAEKYFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I865</accession>
    <name>A0A1W1I865_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2882"/>
    <dbReference type="EnsemblBacteria" id="SLM49049">
        <property type="protein sequence ID" value="SLM49049"/>
        <property type="gene ID" value="NSJP_2882"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2882"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012822704" evidence="1">
        <location>
            <begin position="22"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="158" mass="17920" checksum="AE33BB01EBA8CE1F" modified="2017-06-07" version="1">MYKVMSVVLAGAMLMAVPVFAADAQSDTNMEILKQKLKADKKLLVASNMELTDAEAKQFWPVYESYQKDLEGVNQQLGKTIMEYAEAFNKGTISNDTAKKLLNEALSVEEQETKLKRTYADKLEKVIPATKVARYIQMETKIRSLIKFEMAQQIPLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I876</accession>
    <name>A0A1W1I876_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49204">
        <property type="protein sequence ID" value="SLM49204"/>
        <property type="gene ID" value="NSJP_3037"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3037"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012054322" evidence="1">
        <location>
            <begin position="24"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="344" mass="36751" checksum="B1EE3389C9C8738E" modified="2017-06-07" version="1">MRGVSLRAAAACFTFILAWVHDASGSGVIVDIQSIPQDVCRDSTLTAYSFASTPFTYRFSGNCYLLNTRYALPITVPWTGVGTFDPASGKVTEEINIPEPTAAQPSRPYGRFTASMHCGGKDPWREATACGQIALSVNPPVTAYAPNIYGEYSRQVIQEVLNLYPRGGRPVTSNLSANDRQALVASLQAYTQAEAARQKQTQRLKQSVQPAPTLLANLAPYVVSPAAGSLFMSMTAVPIKLAPPPRRMTVTAYLARIERKDAQGNWTLVTNLPINIADASSASGYLGWGASGNGKGAPMIAGPGTYRISAQVSTPKPTGWSEAVEFVVTAPSKTIQKAPKMFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I898</accession>
    <name>A0A1W1I898_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Phage integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49226">
        <property type="protein sequence ID" value="SLM49226"/>
        <property type="gene ID" value="NSJP_3059"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3059"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="68"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="176"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="422" mass="46578" checksum="6A6743F36D4A7A70" modified="2017-06-07" version="1">MGVRIRERDGAWWIFIHHNKQRKAKRVGPGEAGKKAAKDAARLIQARLALGQAAFDEPPQPEPKADLATVGSYLKAWLKEHAQVNCKPSTYAEYSWCIEHILLPEFGTLPLDALTVAHVRQIIAKYTEAGKSRATIRNYLAPLRAAFTQAEDDGLVSKNPAAKLGKLLKHTKGSAKDIHPLTRQETATLLDTAKAKTPLISPLLFCAVRTGLRRGELIGLQWGDIDLAGRSLLVRRAVVRGVVGPPKSGKPRRVDLSAGLCAELTALRAEHEREAEADGEALKLDAPVFRSPRGFRWDEHNLDKLWRETLKASGIRKVRLHDLRHTFASQLIEQGAYPKYIQEQLGHASITMTMDTYGHLFPNRNRGLVDGLDSLDFEGRNATPAQLTDGACEGASLSARKVVRPTGLEPVTPRSVVWCSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8B6</accession>
    <name>A0A1W1I8B6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49043">
        <property type="protein sequence ID" value="SLM49043"/>
        <property type="gene ID" value="NSJP_2876"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2876"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="70"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="804" mass="88512" checksum="47BAEA17D960C59D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8C1</accession>
    <name>A0A1W1I8C1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3004</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49171">
        <property type="protein sequence ID" value="SLM49171"/>
        <property type="gene ID" value="NSJP_3004"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3004"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="47"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="186" mass="19818" checksum="93861E111E3E5D02" modified="2017-06-07" version="1">MEDIVTHSFHRIVRDCGSAVLFVSLLGSALSVSAAEAGQKRAVIKDGAQVSLEYTLRLDDQTVLESNVGKAPMVYHQGAHEIVPGLERSLAGHAKGDTARIVVQPAEGYGDVDPKAIQEVKKSLIPEAARKVGAQLEAKGPDGESLFPRVTAVTEDTVTLDFNHPLAGKVLLFDVTVLDVLSVPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8P0</accession>
    <name>A0A1W1I8P0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative tRNA modifying enzyme, MiaB-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NSJP_3188</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3188"/>
    <dbReference type="EnsemblBacteria" id="SLM49355">
        <property type="protein sequence ID" value="SLM49355"/>
        <property type="gene ID" value="NSJP_3188"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3188"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006467">
        <property type="entry name" value="MiaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01579">
        <property type="entry name" value="MiaB-like-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="8">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="141"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM49355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="449" mass="49335" checksum="152482FBF714A988" modified="2017-06-07" version="1">MKRASLHTLGCRLNQAETSVLESQLRKEGYELVAFGQPTDLLVVNTCSVTKEAERTCRYVVRKTLKHSPEAFVAVTGCYAQTGWQELRSMAGVDLIVGNQFKWDLPAMLPATEHLRKAPKPEVVHSKTIDRDDFILPDYGTPHSTRASVKIQDGCNVMCSFCLIPFARGHERSRVLEDAIREATLLAAAGYREIVLTGVNIGRYQQDGRDLLALIDALERIDGLERIRISSIEPTTIDDGLIERMAASSKLCPYLHVPLQSGDDTILSAMNRPYRVKDFAKLIERVVRAVPSLGLGTDVMVGFPGESEGAFLNTVRLAETLPFSYLHVFPFSPRPGTAALRMNGSVAPGLVRDRATRLAALDRAKRMWFAERHIGSTLPILFEAGETDGFASGTAPNFLRVAVAASDYLTSTTRSVRISAASERWAVGQVLPARHESKAPQTLSLVSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8P1</accession>
    <name>A0A1W1I8P1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49376">
        <property type="protein sequence ID" value="SLM49376"/>
        <property type="gene ID" value="NSJP_3209"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3209"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032811">
        <property type="entry name" value="Put_conjugal_transfer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13729">
        <property type="entry name" value="TraF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012122244" evidence="1">
        <location>
            <begin position="25"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="380" mass="39474" checksum="F93BCDC120ED77BA" modified="2017-06-07" version="1">MDRASVLRFCAAATALLFSTQAAATEFVIVGPRAMGMGGAGVAVTTDALATYWNPAGLAMTQTVDIRIQAGGQGIDRMGIANAIHDLENFNVNDTSAGNLANAQNIASRINQPGANVSMNGSAGLYVKGHFGEHAFGINVSDVATGGSFVSTPVQATQPGGPNTPISLTGQMALRGLEARQVALSYAYAFADKTFAIGMTGKIIQGAAYNGSTTLTGGTDVSLRDNFGKPVLSTALSLDLGAIYRPSSWLRFGVVAKDITQPTFKSQSGELKLGPQVRGGMAVNPYSTLTLSADVDILSNNTLVPGVKSQLLSLGAEQTILNEFLSLRLGAFKNMQDPGIPFTPTAGLGLRMYAFRLDLGGGYDFREKGALASGSLSLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8U9</accession>
    <name>A0A1W1I8U9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49447">
        <property type="protein sequence ID" value="SLM49447"/>
        <property type="gene ID" value="NSJP_3280"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3280"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="303"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="337"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="401" mass="44538" checksum="77152FC7F31B0DD3" modified="2017-06-07" version="1">MQTMTATGEYRMVAHDTPGDAERLALVAAKSQIHNVTADYLATVPVVQQLGLNQTEIRAYTVGLFEIDQYPARPAESESGTTLSVPVKIHLDPAVVARQLNGLMQNERAKTELMRIRDTLDAYFKELDDDRTRLAKTKEEADVKAILQHRRDVLTRIDTEEQFARTWTTLFSMREAAVPQGRAPQDKHGQSKEPARAPGNAEAHRKKGALLADQGRFDEALVEFHEALRLIPDLDRAHLGLGAALQGKGDLDGAIAEYQTVLKQHPNDAHAHNNLGSALQLKGDAPGAIAEYRKALESEPNDAVTHFNLGTALATNGKGQEAVEAYRTATRLDPDLFQAYFDLGGLLRDNNQPREAVSAFREYLRRAPDTPANRPFIEQARAYLDTVREQRRERLRQGTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9H9</accession>
    <name>A0A1W1I9H9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Biotin carboxyl carrier protein of acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">accB</name>
        <name evidence="6" type="ORF">NSJP_3414</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3414"/>
    <dbReference type="EnsemblBacteria" id="SLM49581">
        <property type="protein sequence ID" value="SLM49581"/>
        <property type="gene ID" value="NSJP_3414"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3414"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00531">
        <property type="entry name" value="BCCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="109"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="190" mass="20454" checksum="861CC633906BB183" modified="2017-06-07" version="1">MTRGKPRRPKKRETPIVLPQSLAGGAGDAGRPFLTGNQSKHIQELVDLLKRNNLTELELEREGVRIRIRHEVGVKTITTAVTDIAPTGAIAVSQPAVAPSGAAEDTAGLVTITSPIVGTFYRSPSPDADPYVEEGDFVKRGQVLCIVEAMKLMNEIESEVDGQVVKILAESTKPVEYGQALFRIDPKATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9L9</accession>
    <name>A0A1W1I9L9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CheW-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49690">
        <property type="protein sequence ID" value="SLM49690"/>
        <property type="gene ID" value="NSJP_3523"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3523"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="164" mass="18163" checksum="B376D42C71C855EB" modified="2017-06-07" version="1">MSLRGHYKAATTNVQVASLLVVRYGIRYCALPSDEVRGVLTKEQAGHGETVNWVGMTYRRVDLAARLSTKLDVASLDLRIVLFSNGHSHGAIHVDEVVGLIDVDRQHCMPLPPHFRCEERSWVTGMIFYRNDLAIVLNPEWVLGELGTEGTLPSRPVTGRSLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9T4</accession>
    <name>A0A1W1I9T4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Fe(2+)-trafficking protein YggX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3583"/>
    <dbReference type="EnsemblBacteria" id="SLM49750">
        <property type="protein sequence ID" value="SLM49750"/>
        <property type="gene ID" value="NSJP_3583"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3583"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3880.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007457">
        <property type="entry name" value="Fe_traffick_prot_YggX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036766">
        <property type="entry name" value="Fe_traffick_prot_YggX_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04362">
        <property type="entry name" value="Iron_traffic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111148">
        <property type="entry name" value="SSF111148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="93" mass="10560" checksum="561C5664E1452E42" modified="2017-06-07" version="1">MTEVQCVTCGQSGEAITDPLFMGKLETEIKSKVCKPCWKKWEAMRVMVINEYQVNLGDESGRELVKKQMKAFLKIGGEPTDTSKLDQNYRPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Z8</accession>
    <name>A0A1W1I9Z8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49820">
        <property type="protein sequence ID" value="SLM49820"/>
        <property type="gene ID" value="NSJP_3653"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3653"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="45" mass="5054" checksum="5A930A90A598B412" modified="2017-06-07" version="1">MFTFEARSSNAMAEAYFKGKDLILSVTFHRGDSLQNKDTLSALLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA47</accession>
    <name>A0A1W1IA47_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49876">
        <property type="protein sequence ID" value="SLM49876"/>
        <property type="gene ID" value="NSJP_3709"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3709"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005625">
        <property type="entry name" value="PepSY-ass_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34219">
        <property type="entry name" value="PTHR34219"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03929">
        <property type="entry name" value="PepSY_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="416" mass="44925" checksum="E7ABF8BC261039F3" modified="2017-06-07" version="1">MKDHVTQWLNQAHAWIGLFSAWILFSVFATGTLAVFDEEITYWMLQPEIQKITTASGPVGFSPEFRTAELFMESPLNGSGGDGLVQLIKWQDKRSFTGQSIDPATGNLLVFRETRGGDLFYHFHYGLLAGLAGVWMVGAAAIAIWAAAITGVLIRRRRFIADLFMAGFRTVSLRSWSDVHNAIGLLMLPFLATITITGLVVLWSIYLAGGTPESGEAGASLAGLLHFGRFGGVVSRWGYFLMGFASSLVVATGLAIRTAKRRRGRGDRSDPLAVQVADRLAVGVVAGLLVAVAAFFWINRVLPAVVPHRADWEVRAFFSVWAICVGFGALRGESALAWRDLLAAAGVLLMLLPGLNLLTTKSHLLATVTDGQWGLAAVDITSLFVGTCLAWVAVRVRRGLVGEFGDRLSTLSVSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAB7</accession>
    <name>A0A1W1IAB7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49940">
        <property type="protein sequence ID" value="SLM49940"/>
        <property type="gene ID" value="NSJP_3773"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3773"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="108" mass="11654" checksum="2FFB42BB25F8DDE6" modified="2017-06-07" version="1">MVTPVINVRLVDELVSDAVGNLVLYVLAIESLPQTGNSRRLPVALETIARPDLDPNDPNLILIGNVRPLGHGLPRIPRFTARQPKTGLCYDVQTIDGGLGRQSCCGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAC0</accession>
    <name>A0A1W1IAC0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49946">
        <property type="protein sequence ID" value="SLM49946"/>
        <property type="gene ID" value="NSJP_3779"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3779"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="55" mass="6315" checksum="B08351321116C4FA" modified="2017-06-07" version="1">MEYTYSARAGGVIEFLPAILRQLRKSKPYALFALLECTFHDVCILQKVEYLCTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAI3</accession>
    <name>A0A1W1IAI3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative Pyruvate decarboxylase</fullName>
            <ecNumber evidence="10">4.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NSJP_3835</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3835"/>
    <dbReference type="EnsemblBacteria" id="SLM50002">
        <property type="protein sequence ID" value="SLM50002"/>
        <property type="gene ID" value="NSJP_3835"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3835"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="TPP_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PTHR43452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="9">
        <location>
            <begin position="8"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="7">
        <location>
            <begin position="199"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="8">
        <location>
            <begin position="384"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM50002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="553" mass="60657" checksum="D8062B8DFC809C17" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAW4</accession>
    <name>A0A1W1IAW4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">greA</name>
        <name evidence="11" type="ORF">NSJP_3987</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3987"/>
    <dbReference type="EnsemblBacteria" id="SLM50154">
        <property type="protein sequence ID" value="SLM50154"/>
        <property type="gene ID" value="NSJP_3987"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3987"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="10">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="9">
        <location>
            <begin position="80"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM50154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="158" mass="17700" checksum="395F30E37A9A94F2" modified="2017-06-07" version="1">MPSPITKKGYDALKAELDRLRKVERPQVIEAIAEARSHGDLSENAEYDAAKERQGFIESRIAEIETKLADARVVEIAGRTSDTVVFGATVSVIEQETRSKRQYTLVGQDEADMKFNRISIQSPVGRALIGKRVGDFVEVTTPAKMVEYEVVEIRFEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAX1</accession>
    <name>A0A1W1IAX1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Polysaccharide deacetylase</fullName>
            <ecNumber evidence="2">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4030"/>
    <dbReference type="EnsemblBacteria" id="SLM50197">
        <property type="protein sequence ID" value="SLM50197"/>
        <property type="gene ID" value="NSJP_4030"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4030"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="94"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="349" mass="39295" checksum="D0922B5BA59D914E" modified="2017-06-07" version="1">MLAGVKTATWKLLADVYYYSGLAQVRNRGRVAILTYHRVVSSDMVRAEHIQPGMYVQSETFEAHAAYLHERFVVLPFAELLEQWRTGELDSSKRYCAITFDDGWYDNYRYAFPILKKYNLPATIFLATDYIGTSRWFWPDELAYIVGDARKRMAEKEFAEALSSALVETSPAAGTTMPVPSLSIESRGEIDSDWLIEQCKHLPSGTIAGFVHRLSQILGVRVPNLRVLLDWNEVKEMAGHNIAFGAHSCSHRILTNIPLAEVEDELIKSHEALLGHDLTPVPVFCYPNGNFDREIQRLTRATGYLGAVGCEIGLEDRRPQDVFALKRISVHEDTAASDPLFALTLSGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAX2</accession>
    <name>A0A1W1IAX2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49923">
        <property type="protein sequence ID" value="SLM49923"/>
        <property type="gene ID" value="NSJP_3756"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3756"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="438" mass="45304" checksum="1B5DCD10C5B956DA" modified="2017-06-07" version="1">MDRSGRTRAVSVRLHAHPPLHDRHRGRALVALTAYLLGIGVLAWMWAVTPALALISATGYVRVASDSSKLLYLGANRAALISTVAQAAAVTSPASVAIRLVTGPVGWAALGVSVGLALYQMHYTPEELTAVKQGAAPSNLQNGTGTVLPNGAVLEPAQSCVYPSCTAGQGQIVTVAIPNKTQATCGLNVQPVAFPLSWFSNLGEAWSGTRNTCVQTFRYVYDGSTANNLVRTGVGTANQQQIADYVSALPASDPKSIESNTSPLGQGVSPTSASTTTSTAVSPSEIPTTVKPVGQVAPTDAVVDPNAPKPAGTQTVPATQTTTTTTTTTTNPDGSTTEATQDTASVSCSAGDHDPRSFGSILQAHLTTWQGSGLLGTLSLLQSLTWPEALPTITFSSSTWGTHQVDFNQWAAVFTVLRTLTIAGAGFAAYRIIFVGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAZ7</accession>
    <name>A0A1W1IAZ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4'-phosphopantetheinyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3776"/>
    <dbReference type="EnsemblBacteria" id="SLM49943">
        <property type="protein sequence ID" value="SLM49943"/>
        <property type="gene ID" value="NSJP_3776"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3776"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="119"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="244" mass="27824" checksum="59CFC68E84DCC118" modified="2017-06-07" version="1">MDGLMRRRLLAGEVHVWCSEPSELERNGLVASAQALLSSDEHERMRRFRFEGDRLTFLATRVLVRQVLSRYEPIAPRDWTFVATSHGRPEIARPSSALRFNVSNTSGLVVLAVTHRLTVGVDVESLSRPAPIEVADRFFAPAEARVLQSLPPSERTRCFFEFWTLKESYSKARGLGLAIPLDRFWFTLEPCRRPRLEIDPLLSDEAEAWHFAQLRPTTEHVIAVCVRRSGETDGDITLGWHRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB60</accession>
    <name>A0A1W1IB60_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative P-loop guanosine triphosphatase, CobW-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4101"/>
    <dbReference type="EnsemblBacteria" id="SLM50268">
        <property type="protein sequence ID" value="SLM50268"/>
        <property type="gene ID" value="NSJP_4101"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4101"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="1">
        <location>
            <begin position="227"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="321" mass="35186" checksum="D3A4DB91FB1B0006" modified="2017-06-07" version="1">MTSSPVPFYLLCGSLGAGKTTLLMRLLEHWKSAGKRAGVLMNEAGEVSIDGPRAGTIAEQVMNLAGGCVCCDTKEDLSWGIAQLVHDHASDLIVLECSGLADPVEVVDAVTDLYTSRLATLERVIALLHPVAGEESHSSRFVTTQAIRCADELILNKRDLYVPGHWEQFKESIVRNNPFARLWETSHARIDPDALLAPRTSIKPSHTNVVFGTARPPGEQVRARYHPIATTVRLPGPVNRGRLLDWAKTLPKDLERAKGFFRFLGDHNLQELQYAPPASATVTPIMLLDEPNHAVVMIGRNYDVDRCVDGLLACIEQPATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB77</accession>
    <name>A0A1W1IB77_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50023">
        <property type="protein sequence ID" value="SLM50023"/>
        <property type="gene ID" value="NSJP_3856"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3856"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012529063" evidence="2">
        <location>
            <begin position="31"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="154" mass="15897" checksum="E56B50F57EC40255" modified="2017-06-07" version="1">MMKSVNLAPMAIFGAVLWFCPTLAPSPVFAADKDKQTKAPKAAPQAKASKPKQDKSKSADAAGTTNACFGMAPKIEKVAPDEGKAGDSVTIKGYQFGPANCLRGVSFGPGRPAKFAFKNDTTVTATVPSGGRKGLAILTVTTASGEDSKAFLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB88</accession>
    <name>A0A1W1IB88_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fructose-bisphosphate aldolase class I</fullName>
            <ecNumber evidence="1">4.1.2.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fbaB</name>
        <name evidence="1" type="ORF">NSJP_4117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.2.13" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4117"/>
    <dbReference type="EnsemblBacteria" id="SLM50284">
        <property type="protein sequence ID" value="SLM50284"/>
        <property type="gene ID" value="NSJP_4117"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4117"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="307" mass="32901" checksum="B013F3DD0E2F89F1" modified="2017-06-07" version="1">MADRVQEILSWYGSDNAGTKTNIARLLRSGKLGGTGKLVILPVDQGFEHGPARSFAPNPAGYDPLYHFQLAIDAGCNAYAAPLGFLEAGASHFAGQIPLILKLNNHDVLHDEKDPLPSVTGSVRDALRLGCAAVGFTIYPGSAHCNAMYEQLRAIAEEAKDNGLAVVVWSYPRGSVLSKEGETAIDVVAYAAQIAAQLGAHVIKVKLPSAHLEQAPAKKIYESTQIPIKTLAERVKHVVQSSFDGRRIVIFSGGAKAEDQNVFEEARAIREGGGFGSIIGRNSFQRPKADAVKFLHTIMGIYAGEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBA7</accession>
    <name>A0A1W1IBA7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50053">
        <property type="protein sequence ID" value="SLM50053"/>
        <property type="gene ID" value="NSJP_3886"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3886"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="260" mass="30221" checksum="64BAA889010982D8" modified="2017-06-07" version="1">MTNIAFITLVILVMAFPGYVLRASYYAGTFTRHVLPKSWTDDIARAILYSLPLHLVAVLGFEWLQHDGFIHTTLTFEVAYRILVGQYDDQLSAITRTLYQNKVHLGGYYTSVLLGAFAVGHGFRWFVWTYKLDVKVPWLLRFRNEWVYTLLGRDVKIPVQHEGGRVYVRLEALTRIPIEEKDKTRLYRGFVEAFTTEESGALRDIFLIDAERGKFRREPAKPVEFYWKPITPGNLLVLKYSEIQNMNVTYLLELPEAPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBB9</accession>
    <name>A0A1W1IBB9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50211">
        <property type="protein sequence ID" value="SLM50211"/>
        <property type="gene ID" value="NSJP_4044"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4044"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="287" mass="33035" checksum="22F5283FC34F006F" modified="2017-06-07" version="1">MMESYPKITVVTPCYNHGRFIEQTITSILDQNYPNLEYIVMDGGSTDNSVQVIEKYQKHLAYWISEKDRGQSHAINKGFHHSTGEVMTWLNSDDCVEPGSLHLIADHVRRYPKIGAFVGHGRIVDTTGREIYFRKAGELTFERFCQWLDGGDFLQPSCFFRRSAWELVGPLDEHTHIAFDVDYWLRMAKCGVQFQAVEALLSTSLSHGTAKTTAFRHHMVIDTAVVVIRAGGEKYVRKRLDEMATQFSYYEANYNMIINHPVVKAVLPLVRLFIKPAARWKDVTPWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBC1</accession>
    <name>A0A1W1IBC1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4108"/>
    <dbReference type="EnsemblBacteria" id="SLM50275">
        <property type="protein sequence ID" value="SLM50275"/>
        <property type="gene ID" value="NSJP_4108"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4108"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010298">
        <property type="entry name" value="DUF901"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34547">
        <property type="entry name" value="PTHR34547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05991">
        <property type="entry name" value="NYN_YacP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="172" mass="19263" checksum="B2618291EBE56CB0" modified="2017-06-07" version="1">MHLIVDGYNLLAAMGGQDRRNGTQLAAGRDGLLRDLSAYRHRKGHAVTVVFDGWQSGQPFEGREDRLGIQIVYSKRGERADQVIQRLAQEFGSDCAVVSSDREVTDYARGHGAFVMGALEFAGKLSSVPVRTIVHKELDRGDEPPRRGPEKRGNPRKLPKSARRRGRQLRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBD8</accession>
    <name>A0A1W1IBD8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ferrichrome iron receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fhuA</name>
        <name evidence="10" type="ORF">NSJP_3916</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3916"/>
    <dbReference type="EnsemblBacteria" id="SLM50083">
        <property type="protein sequence ID" value="SLM50083"/>
        <property type="gene ID" value="NSJP_3916"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3916"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030148">
        <property type="entry name" value="Fiu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF68">
        <property type="entry name" value="PTHR32552:SF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07660">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0798">TonB box</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="STN" evidence="9">
        <location>
            <begin position="72"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM50083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="854" mass="93923" checksum="49BB7DE01FFB6342" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZX4</accession>
    <name>A0A1W1HZX4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">recJ</name>
        <name evidence="10" type="ORF">NSJP_0095</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0095"/>
    <dbReference type="EnsemblBacteria" id="SLM46267">
        <property type="protein sequence ID" value="SLM46267"/>
        <property type="gene ID" value="NSJP_0095"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0095"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004610">
        <property type="entry name" value="RecJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00644">
        <property type="entry name" value="recJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="7">
        <location>
            <begin position="79"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="8">
        <location>
            <begin position="315"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="9">
        <location>
            <begin position="454"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM46267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="567" mass="62220" checksum="6687C130597378AB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZZ7</accession>
    <name>A0A1W1HZZ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46209">
        <property type="protein sequence ID" value="SLM46209"/>
        <property type="gene ID" value="NSJP_0037"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0037"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="114" mass="12835" checksum="A96E97E693CE5CB4" modified="2017-06-07" version="1">MGRSVPTVHRWRNGALAVSGIRQRLLACRDAQSHLAQKLVPSRPLVERNVGHLCYPPERVARLRYGKKRSGDACLQRRGRSSVLAHPVIAVTVGAEILRWISEELGMSFSRKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I001</accession>
    <name>A0A1W1I001_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46173">
        <property type="protein sequence ID" value="SLM46173"/>
        <property type="gene ID" value="NSJP_0001"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0001"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="25"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="199"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="381" mass="42194" checksum="82243778F2E0A06E" modified="2017-06-07" version="1">MKRWSNSGAGMRIGIDASPIVGDRGGVGWHTYYLLEAMLAGADDVEFIGYLRPGSVLPDDARSWRTGGRITWVEAAKWAMRWRGRTDRLDLYHGTNFKLHTVGRYGGIVTIHDLWLERFPQYSTKVLGQGLASMKARRTAGRARTVVTVSEFSARELSELYAVPRERLSVIPNGVADDFSVRRDDRAMAELRARIRLPDGPYLLFIGGADPRKNHRRFLEAAHLMRGPLQGRRLLLVGSPDHAFGSYQESAKTYGLTAQVCCPGRLGRADLQLLYTYADQFVFPSLYEGFGMPVLEAMACGTPVITSRTTGVAEAAGDAALLVDPEDARSVGEAMVSLLEDASLRASLTAKGFERVKRFSWRSAAAKTLDVYRRLCQERGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I016</accession>
    <name>A0A1W1I016_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="1">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="1">MTA phosphorylase</shortName>
            <shortName evidence="1">MTAP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">mtnP</name>
        <name evidence="3" type="ORF">NSJP_0178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0178"/>
    <dbReference type="EnsemblBacteria" id="SLM46350">
        <property type="protein sequence ID" value="SLM46350"/>
        <property type="gene ID" value="NSJP_0178"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0178"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="15"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="1">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="1">
        <location>
            <begin position="97"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="302" mass="32456" checksum="B9CA51F05BB2F201" modified="2017-06-07" version="1">MAMIKVRRGRAWQADVGIIGGSGLYDLDGLRQVKEVSVRTPFGAPSDAVVLGELDGVRIAFLSRHGRGHTRSPSEINYRANVYALKSLGIRRLISVSAVGSMKESIKPGHVVFPDQFIDLTKQRESTFFEGGAVAHVAFGEPICPSLASHLSSAAHSVGATAHGGGTYVCIEGPQFSTKAESRLYRQWGVSVIGMTNLPEAKLAREAELCYATIALVTDYDCWHETEEPVTVEAILATLRQNVALAKRLLRASIPSAAAGGECACQRALREAIVTDPARIPAALRRKLAVLTDRLSPAKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I057</accession>
    <name>A0A1W1I057_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Thiamine biosynthesis protein ThiS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0218"/>
    <dbReference type="EnsemblBacteria" id="SLM46390">
        <property type="protein sequence ID" value="SLM46390"/>
        <property type="gene ID" value="NSJP_0218"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0218"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="64" mass="7218" checksum="348BE19F0AD9432C" modified="2017-06-07" version="1">MQVQLSHPSRTVDVKGPKKVKDLLKELNLVVEAHLVIRGDELVTEDEMLYDKDHVEIRPVISGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0B2</accession>
    <name>A0A1W1I0B2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46438">
        <property type="protein sequence ID" value="SLM46438"/>
        <property type="gene ID" value="NSJP_0266"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0266"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="59" mass="6282" checksum="2EA5C1630C1305A2" modified="2017-06-07" version="1">MTLFRMQWYRPVSFVRHFLHSTPGGMVDDQAVFVGSGTHACAAGSTSGYGEADDSSPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0B4</accession>
    <name>A0A1W1I0B4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Macrocin-O-methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0252"/>
    <dbReference type="EnsemblBacteria" id="SLM46424">
        <property type="protein sequence ID" value="SLM46424"/>
        <property type="gene ID" value="NSJP_0252"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0252"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008884">
        <property type="entry name" value="TylF_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40036">
        <property type="entry name" value="PTHR40036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05711">
        <property type="entry name" value="TylF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="266" mass="29081" checksum="BA4C5723E0540764" modified="2017-06-07" version="1">MIGRVVTTFNRWIGGSPPSSAAGDVRVTRAAGSANDHPLENYDDEEAARGALEVVRPYTMLSYRRLITLWQQIRYLDTASVPGAMVECGTWKGGACGMMVLAHRCAGDVSRPLHLFDSFQGLPEPQSEKDGDMAVRYAADRASGSLNGIGKCVGPLEDNQRLLGEIVGYPSELTHYHVGWFQDTLRTVPETVGTIALLRIDGDWYESTKICLESLYAKVSSGGIVVIDDYGKWPGCRKAVDEFLSTLARPVFLNHIDAAGRYVIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0B9</accession>
    <name>A0A1W1I0B9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">secF</name>
        <name evidence="10" type="ORF">NSJP_0121</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0121"/>
    <dbReference type="EnsemblBacteria" id="SLM46293">
        <property type="protein sequence ID" value="SLM46293"/>
        <property type="gene ID" value="NSJP_0121"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0121"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM46293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="305" mass="33126" checksum="CF5B2B40DC255218" modified="2017-06-07" version="1">MLEILGKTNFDFMGKRNISFAFSGIMVVLGILAIIQIGRGAANLGIDFAGGTAVQLKFNQPIKIDEARKALETNGLGDAELQEFGQDNKLLIRVKASTTLEHKTAERVVAIFSKEFPGNTFIVDSSTEIGPTIGKKLQEDALIAVLVSFVGIILYIAARFELRFGVAAALATFHDVLAVLGAFYILDKEITLLVVTALLTLAGYSLTDTVVVFDRIRENLRVRRRDSEEMMINTAINQVLSRTIVTSLTVVLVLIPLAVGGGEVLHDFSLALLWGVVFGTYSSIFVASPLLLLWPGTTGRLLKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0G4</accession>
    <name>A0A1W1I0G4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46474">
        <property type="protein sequence ID" value="SLM46474"/>
        <property type="gene ID" value="NSJP_0302"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0302"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="62" mass="6947" checksum="677A9DEFCC7242C5" modified="2017-06-07" version="1">MGDVKPTMQWAEQTLRKLSEHGYTGTVTIRFTQGGVQGMSVNQELNPHQQAAFQQHVAIHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0K0</accession>
    <name>A0A1W1I0K0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogen peroxide-inducible genes activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">oxyR</name>
        <name evidence="3" type="ORF">NSJP_0349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0349"/>
    <dbReference type="EnsemblBacteria" id="SLM46521">
        <property type="protein sequence ID" value="SLM46521"/>
        <property type="gene ID" value="NSJP_0349"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0349"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="305" mass="34015" checksum="EDAD74EE226DBCD6" modified="2017-06-07" version="1">MTLTELKYLVAVAQERHFGRAAERCHISQPALSLAIRKLEEELGTSVLERRKNQITLTALGEKVVQQAQRVLEAAEQIPLIVAQGKDQLVGVFKLGVIATVGPYILPDLIPLLHRRAPSMPLEIEENLTVNLNQMLQHGQLDAIIVALPHEETGILTQPLYEEPFKVVIPVTHPWAKKKRIETDDLGTEKVILPHAGHCFRRQLLDHCPEISRSDREGIQGNSLETIRQMVASGLGITVLPCSALSPKHHHKRLLAIPFTDPVPERQIGLAWRKGFARPAALEAIQETVRLLKIPGLTMQKESHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0M1</accession>
    <name>A0A1W1I0M1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46546">
        <property type="protein sequence ID" value="SLM46546"/>
        <property type="gene ID" value="NSJP_0374"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0374"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="142" mass="15234" checksum="7F150CDA8CE9CEE3" modified="2017-06-07" version="1">MHNSSPLFVTKVGIRVVMTGGCLLLGLAAACVPGPPTQPGDPFGGPGRLTGEPRPATVEQIRLMDAQLAATVTPRPPERDLAGLRMQVAKARKQSERQTLVHEYLHAVAGLAPEEKNTAMRQLGDSLVQSRASLIQELKRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0M5</accession>
    <name>A0A1W1I0M5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4412 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46534">
        <property type="protein sequence ID" value="SLM46534"/>
        <property type="gene ID" value="NSJP_0362"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0362"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025524">
        <property type="entry name" value="DUF4412"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14371">
        <property type="entry name" value="DUF4412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4412" evidence="1">
        <location>
            <begin position="37"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="241" mass="27256" checksum="9EC73F658F50F03B" modified="2017-06-07" version="1">MKWTAGRRTLLPALMVMMIPSGIVIAMSFSPAFAASFEGVVHFKSNYWGEESEFDYYSKGNKARMETNRSRHGRAAVIMDLDARKVSMLLLSWRLAMVMNMEEASRLASVRPVGSLVKTGKTRTILGYHTDQFIHTGQEEETEIWGTTGLGVFIGLHTRASGFGRAGDSPEWVRALRDQKIFPLVVIRMNNGKAQARMDVTDIRNEVLSEELFVVPRRYLTYDKFDPNNKMPGMPGTVWIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0P4</accession>
    <name>A0A1W1I0P4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glucose-fructose oxidoreductase oxidoreductase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46552">
        <property type="protein sequence ID" value="SLM46552"/>
        <property type="gene ID" value="NSJP_0380"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0380"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008354">
        <property type="entry name" value="Glc-Fru_OxRdtase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01775">
        <property type="entry name" value="GLFROXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="32"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="172"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="393" mass="44207" checksum="178DE3BBCFE60042" modified="2017-06-07" version="1">MLSVKRTVAESVQPYGPRQGMRRPVQTIMKRIRYAVVGLGHIAQAAVLPAFAHTASNSQLTALVSGDPAKLRTLSRRHNISHTYRYAQYERCLREGHIDAVYIALPNSLHCDFAVRAARAGIHVLCEKPMAVTAEECRRMIRAADGRRTKFMVAYRLHLEQANVKAVQIARSGKLGTLRIFNSVFTMQVRPGNIRVRRQLGGGSLYDIGVYCINAARYLFQDNPVEVSGFSVKETDRRFREVDKMSGALMRFPGDRLASFVCSFGAADVSSYEIVDTKGRLLLDPAFEYVGSHTQRVTIDGDTKAERFQPGDQFAAEIIYFSDCIRYDREPEPSGLEGLIDVQIVQALYQSAKRRKSVTLNLPAKRRWPTVKQVIHRPPVSKPRLVRTRSPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Y1</accession>
    <name>A0A1W1I0Y1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Intradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_0331</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0331"/>
    <dbReference type="EnsemblBacteria" id="SLM46503">
        <property type="protein sequence ID" value="SLM46503"/>
        <property type="gene ID" value="NSJP_0331"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0331"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTRADIOL_DIOXYGENAS" evidence="4">
        <location>
            <begin position="58"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="246" mass="27033" checksum="8A121DB8356C5178" modified="2017-06-07" version="1">MTDHVLLSSVFRRQLSRRDTLALLGKSAVCLVTAGLWPRVAGAAGPDPLCVVRPTQTEGPYFVDEQLNRSDIRSDPSGGAIKTGTPLSLTVAASRLGGGACHPLEGAHVDIWHCDATGLYSDVKDPRFNTTGQQFLRGYQLTDAKGEARFLTIYPGWYEGRTVHIHVKVRANPKDRRGYEFTSQMYFDDALTDRVYAAAPYAARGPRTARNHDDFIFRRGGNRLMLDPTQTADGYAATFAVGLQMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I111</accession>
    <name>A0A1W1I111_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0516"/>
    <dbReference type="EnsemblBacteria" id="SLM46688">
        <property type="protein sequence ID" value="SLM46688"/>
        <property type="gene ID" value="NSJP_0516"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0516"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="88"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="257" mass="27358" checksum="EB5CA65A75677C79" modified="2017-06-07" version="1">MPGPEERPPTTTSTQSTVVAHMMTPGVVQVPGDVSVSEAALMLEREQAPCLLVKDTDDQFGVMTPHDIVKKVVAQGLEPHEIEVRTIMTRPVQFIEYDQALEEAATIMVATGASLLIVTKQNQPVGVLTAHNLMLTPPRRATQIPTVITVMGDDPSLQHAHNAVISQLSHLGSLVHSKTHIATKSRVVLAFSLPGQNTPLTIHGKVLSSGASSVPPIEPSGEGMSASEIQFIDPSDANLARLKAWALQALPASSQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I113</accession>
    <name>A0A1W1I113_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46677">
        <property type="protein sequence ID" value="SLM46677"/>
        <property type="gene ID" value="NSJP_0505"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0505"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="138" mass="14872" checksum="6531182B2C085BC4" modified="2017-06-07" version="1">MTISSARLSLHRSLPYIGIVCLFLAGGCATSPSERQGQRSDIEIGTTTKADVLKRYGAPDLVQMLPDGEIATYRPSASPQAKPTVSVPTVQAGPAGMMTTQNQTVEPGLGKNTRSSNRLQTELQIRYDQQGVVRELIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I125</accession>
    <name>A0A1W1I125_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46706">
        <property type="protein sequence ID" value="SLM46706"/>
        <property type="gene ID" value="NSJP_0534"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0534"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007437">
        <property type="entry name" value="DUF486"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38482">
        <property type="entry name" value="PTHR38482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04342">
        <property type="entry name" value="DMT_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021239">
        <property type="entry name" value="UCP021239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="117" mass="13709" checksum="E9BADF0443043730" modified="2017-06-07" version="1">MNFLLTITLLILSNIFMTVAWYGHLRFMDRPLWVVVIASWGIAFFEYCLQVPANRFGYHALTAYELKTLQEVITLTVFIVFAQLYLGEQLRPKHLAGFILLTVAAWMVFQDRYGLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I130</accession>
    <name>A0A1W1I130_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinate semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gapD</name>
        <name evidence="3" type="ORF">NSJP_0530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.1.16" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0530"/>
    <dbReference type="EnsemblBacteria" id="SLM46702">
        <property type="protein sequence ID" value="SLM46702"/>
        <property type="gene ID" value="NSJP_0530"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0530"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009013">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="15"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="476" mass="50335" checksum="140AA430FBF46A0A" modified="2017-06-07" version="1">MQGPRPFLIGGQWRQGKTVLPVHDPFTGKVLVEVAQAGPDDASDAAQSTSDAARQMAALPSHGRYHLLQKIAGALYDRRDEFAQVMTAEAGKPIADAKREVSRAVQTFTVAAEEARRIPGDVIPLDWTPGTDSHLGILRRVPIGPVLGITPFNFPLNLVAHKVAPALAAGNAILIKPAPQTPLTALLLGEVAMEAGVPPGGLNILPCDNAVAEQLVTDSRFKLLSFTGSAAVGWKLKALSGKKKVVLELGGNAGVIIEPDADLELATQRCAAGGFAYAGQTCISVQRIFVHHSIADLFTTKLLLQVARLKAGDPGDGGTVVGPLIDQGAAKRVEGWIAEAVSQGARVLLGGKRLGSVVEATVMGNVTPTMKVSCQEVFGPVVTVTPYQEFEEALEALNQSDYGLQAGVFTQNVDKIFRAFQRLEVGAVLANEIPSFRTEHMPYGGVKDSGLGREGVASTIEDMTEPRLLVLNLKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1C6</accession>
    <name>A0A1W1I1C6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46808">
        <property type="protein sequence ID" value="SLM46808"/>
        <property type="gene ID" value="NSJP_0636"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0636"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="73" mass="8026" checksum="3F619BEC5AD84472" modified="2017-06-07" version="1">MQPARRASIAMRASLSNLHDCIHYRAFPYVVIFTGSFVVGISNAPKHGLGTHLDSPSQCPTKYSPSHQPMRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1J7</accession>
    <name>A0A1W1I1J7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46851">
        <property type="protein sequence ID" value="SLM46851"/>
        <property type="gene ID" value="NSJP_0679"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0679"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="140" mass="15137" checksum="E68EA6479A7A54D2" modified="2017-06-07" version="1">MSAKSTGVDIKLMGGLFLIVGAVDLVIIVMFPSYALKLFGTIVTGPLSFPAKLHSPAVHLLIGYGFLWLRPWAWGLSLAYAGFGLASEALNQLAFGFHPVRSGFMVTTALFIIYLYSRRRLFTDQPGMPTTGPSVSEGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1K2</accession>
    <name>A0A1W1I1K2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0700"/>
    <dbReference type="EnsemblBacteria" id="SLM46872">
        <property type="protein sequence ID" value="SLM46872"/>
        <property type="gene ID" value="NSJP_0700"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0700"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="90"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="270" mass="29548" checksum="7CFCD3FD935E4CD7" modified="2017-06-07" version="1">MELTPFLFGLYKTAKYVLYPLSWVVILLTMTTWLLLLPSTPSRLRWARIGSCACLFTLLLISSPLLSSQFIGMLEAVYPATPEPAQRPFDAIVVLGGGILDRGTLRPSVDLTSLSRERTTCGADLYLRGYASKLVVTGGDASVFGSGPIEAVEMKRWANRLGVPDDVILIDNTARNTYENATATHRLLQDASIVLVSSASHLPRAAALFKKQGFRVTPVPCGYFSRNRPGDVAEDLTLFQLLPADSAISHTREAVVETMGAFFHRLMGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1V6</accession>
    <name>A0A1W1I1V6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized 37.6 kDa protein in cld 5'region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0805"/>
    <dbReference type="EnsemblBacteria" id="SLM46977">
        <property type="protein sequence ID" value="SLM46977"/>
        <property type="gene ID" value="NSJP_0805"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0805"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="340" mass="37930" checksum="12797A8B56ABA80A" modified="2017-06-07" version="1">MGDSNRAILVTGAAGFIGFHVVKRLIARGDSVIGLDNVNDYYDVRLKQARLAQLTPLEGFQFVKLDLANRLGMKELFAEHPIKRVVHLAAQAGVRYSLINPHAYTDSNIEGFLNVLEGCRHAKVEHLVYASSSSVYGGNTHMPFSIHDNVDHPVSLYAVSKKANELMAHSYAHLYGMPCTGLRFFTVYGPWGRPDMALFIFTKAILEGQPIDVFNQGKMRRDFTYVDDIVEGVVRTLDRPAESNPQWSGDTPDPGTSSAPARVYNIGNHQPVELLRFIEVLEEAVGKKAEKRLLPLQPGDVPATYADIDDLARDVGFKPATPIEVGVPRFVQWYREFYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I224</accession>
    <name>A0A1W1I224_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46873">
        <property type="protein sequence ID" value="SLM46873"/>
        <property type="gene ID" value="NSJP_0701"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0701"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="120" mass="13745" checksum="E983DEE6C672BB56" modified="2017-06-07" version="1">MAWSGHVIGLLKEYMHDLVEQARQESDAEASFGFAPVPYRSDQALSDLLAILDDRIESEGMQVGLPADFLHDMWTQCNEGRNWVSQRVWLELNSNDSTQSKARIRELTYRALVDFLEGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I250</accession>
    <name>A0A1W1I250_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_0879</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0879"/>
    <dbReference type="EnsemblBacteria" id="SLM47051">
        <property type="protein sequence ID" value="SLM47051"/>
        <property type="gene ID" value="NSJP_0879"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0879"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="25"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="125" mass="13750" checksum="F1BAFAD47705AA92" modified="2017-06-07" version="1">MPVSGIIWILIALISWSQAWSATPEELEQGRTIYERHCADCHGMDGRGDGTLAASLSPRPGNFVSAQTSAKSDQDLLKVIAKGRPRTAMQGWNDRLSEKEQLATLAYIRSLVRFSRSATPPPPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2A4</accession>
    <name>A0A1W1I2A4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="NSJP_0974"/>
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    <dbReference type="KEGG" id="nja:NSJP_0974"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
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    </dbReference>
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        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012370780" evidence="1">
        <location>
            <begin position="34"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="549" mass="61479" checksum="648C612F4C6EF69C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2G1</accession>
    <name>A0A1W1I2G1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="NSJP_0989"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0989"/>
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        <property type="component" value="Chromosome i"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <location>
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            <end position="684"/>
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    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="829"/>
            <end position="846"/>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="979"/>
            <end position="998"/>
        </location>
    </feature>
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        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1074" mass="118967" checksum="7E3121828DC8F9FE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2I8</accession>
    <name>A0A1W1I2I8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">NSJP_1030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 2" key="1">
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="NSJP_1030"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="323" mass="35485" checksum="148271BC541A4E41" modified="2017-06-07" version="1">MKGLSRESRKLTVKSRRGGASASRNLILLGSLVMSVFLAPYGFADEGHSQGAATHLKVSGVVAKVQATHVVIKTPWGQMKIASQVLPKGLEVGEEVDMWVNENNAVIDVHRKGDPSHSHKFVTGSLAYTSTDKTEIKLQTPEGEKTFDVQTGKSKLSSIAEGSPVTVEVNEEGKVIDVHRFDVEMTFNKQPRTKAGYHITAHGVVEKIQSGVVAVKTPSAMYRLNQKSMPSGIKVGDEITLWVNEENMVIDHHMKGHTQAHRLISGKLIYVGKSKKEIKLWTPEGEKVFPLDRLEVKAKPIKEGTPVTVELNEQGVVINLWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2N6</accession>
    <name>A0A1W1I2N6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="NSJP_1096"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="138" mass="15251" checksum="BC1F26D324319FA4" modified="2017-06-07" version="1">MKLRATYRGGLRYDITSGRHHVVTDQPVLDGGEDAGMSPVELFVGSIAACVAYFVGRFCARHEIPREGLTVETEWATEEGPHRVGRIRLAVHLPHPVPPELKERLLKTAQRCTVHQSIVTGPQIDIALHQASQDKAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2S6</accession>
    <name>A0A1W1I2S6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_1135</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47307">
        <property type="protein sequence ID" value="SLM47307"/>
        <property type="gene ID" value="NSJP_1135"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1135"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="157"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="232"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="309"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="361"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="453"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="690"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="638"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="826" mass="91438" checksum="E8D38B947F430735" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2S9</accession>
    <name>A0A1W1I2S9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_1136</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47308">
        <property type="protein sequence ID" value="SLM47308"/>
        <property type="gene ID" value="NSJP_1136"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1136"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="143"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="10">
        <location>
            <begin position="217"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="445"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="10">
        <location>
            <begin position="520"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="613"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="854"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="807"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM47308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="972" mass="108572" checksum="44B31F3E083B1134" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2W0</accession>
    <name>A0A1W1I2W0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1160"/>
    <dbReference type="EnsemblBacteria" id="SLM47332">
        <property type="protein sequence ID" value="SLM47332"/>
        <property type="gene ID" value="NSJP_1160"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1160"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="251" mass="27250" checksum="2BD460E5C5F87292" modified="2017-06-07" version="1">MTCVAPVPSVAPKSLSAASASDDERPHTLSVDVGSTWIRALVLDGRGHPVRPLHEVGFAKTPSHPTPEALMETVASLGTRAEPFGRASIGFPGVLHDGIVCRSAVFGPEWMEVPLAPLMELRLRCPVKAVRAIDLHGWGVIHGRGTELLLAVGSRMDVALFRDGVPVPNMTLGKYRPDPARFELDGPAAWTRRFWKMAADLRKRFHYDRLYIGGPYAGRMGMIPLPSDVTITASLNGLLGGVAPWDGRRYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Z7</accession>
    <name>A0A1W1I2Z7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Superoxide dismutase</fullName>
            <ecNumber evidence="2">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_1206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1206"/>
    <dbReference type="EnsemblBacteria" id="SLM47378">
        <property type="protein sequence ID" value="SLM47378"/>
        <property type="gene ID" value="NSJP_1206"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1206"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_C" evidence="6">
        <location>
            <begin position="102"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="211" mass="24293" checksum="816B40C3F0BD7B1C" modified="2017-06-07" version="1">MPHFPPYRVKSFNLHGLQGISDKTVDLHLSLYEGYVKATNALQGRIAEFLKDGSVDQEEMPAYSELTRRLGFEYNGMVLHEHYFENLSSQASLKPEGSSAFRRRAEASFDSFDRWQADFSSVGKMRGVGWAICFQDPESGRLTNHWVTLHEHGNVAGFAPVLVMDVWEHAYLLDYAPSQRAQYIDAFFSNINWRIVDRRVEDTERLRKRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I303</accession>
    <name>A0A1W1I303_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47396">
        <property type="protein sequence ID" value="SLM47396"/>
        <property type="gene ID" value="NSJP_1224"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1224"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="18"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="70" mass="8057" checksum="A2283416457D6189" modified="2017-06-07" version="1">METVTNNKKPSFEELGDWLSPEEVRVFLGLGRATVYELIRSRQLPSRRFGRRIRVPKAALSPRIESMVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I304</accession>
    <name>A0A1W1I304_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47374">
        <property type="protein sequence ID" value="SLM47374"/>
        <property type="gene ID" value="NSJP_1202"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1202"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="434" mass="45813" checksum="BF775AE7EA23FAB7" modified="2017-06-07" version="1">MPLNSTTPFSAFTSNPTAFRVSLRANRSRTRWAMVSSCFLDRVARRAGEGVNLLTTESTPSIFFTISAARVFSSSVGTLPLSTALRLSTSTSISNGKSSGSPISASLMVKLSEVTGFFPDSSVLACAGSSGLAFSSTLAFSSTLAFSSLFVLSSALTLSSAFPFSSVLAFSSVFGFSSIFAFSSDFPLSSLRPLSSALTFSSDLPLSSTLGFSSLAFSSAAGLAPASGLASESGFFFDSGAAPESLDRSSLLSDASRRATSQDRTRKHRNASQPTAPAFRMIPDNAPKCRLLPITFTAFTGREIIFAASFRNCLPGDSLGIPHLSDIHTTDRGGSTAPCHATDDTSGARDAVATGQGISQLGEWEALAMVRMASGATMRRNISEHKWNITHEIDARVRDDHGRRERLTIASLDGSAEQTGCPVRRDLSNRGFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I319</accession>
    <name>A0A1W1I319_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47400">
        <property type="protein sequence ID" value="SLM47400"/>
        <property type="gene ID" value="NSJP_1228"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1228"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="174" mass="19499" checksum="8842F5855507940D" modified="2017-06-07" version="1">MVKRQAQAQEDLERLNCEIRDAERSQASSTTLTKLRSARTTAKETSDDVQMCLEAFPRELELAEGAVIGAKRACTAERYTALVECQRKLVQMISEALERIFQSMKMKESLAIQQRQLLAGIGNYNFSLESVRLATCVELGKRFAIAAGSPERPTSIMELDWTCRYMNRGGGLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3G4</accession>
    <name>A0A1W1I3G4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47538">
        <property type="protein sequence ID" value="SLM47538"/>
        <property type="gene ID" value="NSJP_1366"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1366"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="213" mass="23525" checksum="4D6C9C5F15539C64" modified="2017-06-07" version="1">MIVSYLLILLVLVPWQADPVQAQPELRTLIRQSLDECHLGRIAQERALRLTHFEKGQRLGEQAVSLDDKSPDAHFALFCSLGELMRLDGEMSLGSVLGFRRMMKELDRTIELAPDHLDALSAKGTFLVRLPAMLGGNPDTGEQLLRRVIAGEPTAVNARLSLAKSYCARGRHNEAIVLASEALALAEAQHRDDFIPEAKRVMAQLHAAADTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3J2</accession>
    <name>A0A1W1I3J2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47535">
        <property type="protein sequence ID" value="SLM47535"/>
        <property type="gene ID" value="NSJP_1363"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1363"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="74" mass="8568" checksum="4C4443BECE05B150" modified="2017-06-07" version="1">MSQILNLSEHTSDDELQRLTTLLLFHLVELCGGQVQFKMEDALRVRSSLTTKMVQMQVGDEVRLRIIDRLPELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3L2</accession>
    <name>A0A1W1I3L2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47555">
        <property type="protein sequence ID" value="SLM47555"/>
        <property type="gene ID" value="NSJP_1383"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1383"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="123" mass="13893" checksum="39A6FAA27191DE40" modified="2017-06-07" version="1">MNPTLQRAVTSFYNLVYEAQTFATAMARIDTAEQEHYAGRIEGLNWVLDRCQELEDMDANLTPSSLQRVLTEVKSDLDHELSVQRREKGRRADGREEALNFVADYLSSLITATEIESAKTPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3S4</accession>
    <name>A0A1W1I3S4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cztS</name>
        <name evidence="9" type="ORF">NSJP_1357</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1357"/>
    <dbReference type="EnsemblBacteria" id="SLM47529">
        <property type="protein sequence ID" value="SLM47529"/>
        <property type="gene ID" value="NSJP_1357"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1357"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="187"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="248"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="463" mass="51499" checksum="983968A2677E092C" modified="2017-06-07" version="1">MPLRLRLTLWYGSALALVLIIFSTVLYLVTARNLRDSVDQSLEETAAAAVRSLEERGFLPLINEEELMSQFPELARIDKFFQIFSPSGTITIRSPNVKQHELPLSRQALEVAFTGRTIFESAKYPKEPPLRLISVPIIYRSNLLYIVQVGTSMESVEQTLNRLLLVLLVTTPVALTISLAGGWFLAGRALRPVDAITLAAQRIAGGDLTQRLNVPTSADEIGRLAGTFNNMIARLETSFRQIRQFSSDASHELRTPLTVMKGETELALRRPREAADYTVVLESTLEEIDRMTRIVDELLFLSRADMGEVKMEYLPVNLDVLLEDISRQASLLGQERDVQVILGPITPIVVRGDELRLRELFLNLVDNAVKYSRRGGAVEVTMTTVPGYAKIVVTDHGIGIGPDDLERIFGRFYRTDDARAHTKKGTGLGLSICAWIADSHHGRIEVKSDLGKGSTFTVLLPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3X9</accession>
    <name>A0A1W1I3X9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pantothenate synthetase</fullName>
            <shortName evidence="5">PS</shortName>
            <ecNumber evidence="5">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">panC</name>
        <name evidence="6" type="ORF">NSJP_1544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1544"/>
    <dbReference type="EnsemblBacteria" id="SLM47716">
        <property type="protein sequence ID" value="SLM47716"/>
        <property type="gene ID" value="NSJP_1544"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1544"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="184"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="294" mass="32715" checksum="FF196B72B593152E" modified="2017-06-07" version="1">MKIIRNLHAMTLWSDRLRREGVTIGFVPTMGALHDGHRALIRAARLRCDALVVSIFVNPAQFGPKEDLSRYPRPIARDRRLCRAEGVDVCFEPTPADMYSERFQTSVMVPELAGRWEGTARPHHFGGVATVLVKLFSLVRPHHAVFGQKDFQQAALVRRLIADLNLAVGLTVHPTVREPDGLAMSSRNVYLSPDHRRRAPVLYRALSAGRQAILDGLRDGRQVDRIMKRMMAEDRIVRPEYLAVCDAASLEPLKKVSGSVVLLGAIRIGRVRLIDNVTVAVPSAGSARRGRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Z5</accession>
    <name>A0A1W1I3Z5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-(S)-hydroxypropyl-CoM dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.269</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">xecE</name>
        <name evidence="1" type="ORF">NSJP_1499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.269" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1499"/>
    <dbReference type="EnsemblBacteria" id="SLM47671">
        <property type="protein sequence ID" value="SLM47671"/>
        <property type="gene ID" value="NSJP_1499"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1499"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050575">
        <property type="term" value="F:2-(S)-hydroxypropyl-CoM dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="251" mass="26102" checksum="A6A5B578F046849C" modified="2017-06-07" version="1">MSRMLGKVAIITGGNAGIGEAVAKRVAAEGGLVVITGRRQAELDRVVLDIESKGGHALAVAGSVADEAHARDTVATALKTFGRIDGLVNNAGVGDFGKRIHETDDATWANVIDVNVTGVLRMTRAVVPHMLKQGRGSIVNISSIASVVGIPALPAYAASKGAVDALTRAIAVDYAQDGIRCNVVNPGLIDTPMAAPLMANPEQLAPILTHYLLKRPGKPEEVASMVLYLLSDEAAWVTGGTYMIDGGMTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I442</accession>
    <name>A0A1W1I442_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_1600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1600"/>
    <dbReference type="EnsemblBacteria" id="SLM47772">
        <property type="protein sequence ID" value="SLM47772"/>
        <property type="gene ID" value="NSJP_1600"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1600"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="378" mass="40946" checksum="F9E2D52E9E4B3076" modified="2017-06-07" version="1">MQAVDSCLPPGDKPRPPNIQGDIPPSGGQTIRSVALTGLFILALLYTLHLGQVVFLPLTIAVMLSVLLAPIPRWLRRIHVPEPVSATLLLSIVVFGLGYGMTFLAEPAAGWLEKAPHVFREAEYKLRVIKKPMQELSKAGELIATATTLDEAKKVQKVEIHNGIWPARMFTITSELLMGGATMLILLFFLLSSGDLFLEKLVKILPTFEDKKRAVEIVREIEHRLARYLVTVSGINIALGIAVGVGMHLLGMPNAPLWGVMAAMLTFIPYLGHMIGVSVVTLVAAVTFDDLGQILTVGGLYWALAVIEGTLVNPMIVGHRLELNPVIIVVALMLWGWIWGIGGTFVAVPLMVGVKIFCDHIEPLAPIGEFLGAREGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I496</accession>
    <name>A0A1W1I496_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47847">
        <property type="protein sequence ID" value="SLM47847"/>
        <property type="gene ID" value="NSJP_1675"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1675"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012574128" evidence="2">
        <location>
            <begin position="24"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="122" mass="12679" checksum="9FC6684B0FBE1318" modified="2017-06-07" version="1">MKLVFGTLAAASGVLFALSMASANPALLPKHEGYPMKNSGSPVTGQPTANDPGQGDARGESTLTKAAGFDDKHAQQDLKKKDNERITANEGAGRLPKVQGPQIQIAPPVTSATKITGDRKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4P2</accession>
    <name>A0A1W1I4P2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="1">1.1.1.42</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Oxalosuccinate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">icd</name>
        <name evidence="6" type="ORF">NSJP_1802</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the monomeric-type IDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1802"/>
    <dbReference type="EnsemblBacteria" id="SLM47974">
        <property type="protein sequence ID" value="SLM47974"/>
        <property type="gene ID" value="NSJP_1802"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1802"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004436">
        <property type="entry name" value="Isocitrate_DH_NADP_mono"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36999">
        <property type="entry name" value="PTHR36999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03971">
        <property type="entry name" value="IDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009407">
        <property type="entry name" value="IDH_monmr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00178">
        <property type="entry name" value="monomer_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="134"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="84"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="549"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="586"/>
            <end position="587"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="591"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="602"/>
            <end position="604"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="651"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="2">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="2">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="743" mass="81375" checksum="6A5CAB19CA4C04CB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4R9</accession>
    <name>A0A1W1I4R9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1641"/>
    <dbReference type="EnsemblBacteria" id="SLM47813">
        <property type="protein sequence ID" value="SLM47813"/>
        <property type="gene ID" value="NSJP_1641"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1641"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="445" mass="48493" checksum="6979F3CBF03104B8" modified="2017-06-07" version="1">MTFRHGARMGDCKIGRMSGRASRRISAWLMAISLLGSIAWAGESGSPAGLGAKHVTVHQVKNVVGPTVQIDESGIVSAAWVEEDKEVRTIWFARSKEPGGPLGPPVRINDPSENPYYRQESPALVVRGNDVFVTWALTHPKMTPDKPFSSELRLSRSTDGGRTFAPSTLVNDDGQVINHTFDAMQVAPDGSVHVAWIDGREGKKEPGTFVAKSGDQGRTFAKNLKVDENTCVCCRTALATSNDGVVYLAWRKIFEGNVREIVVSRSVDGGTEFSAPAVVGQDRWVYPACPHRPASLGVDRRGRVYVTWYTEGADETPAIYLAYSDDQGRTFSSKKQLNRSKGTFPDHPQMAVDPEGHVVVAWEEQSPVRREVVVSRSFDRGESFSAPVKVNEKNGQTPTVAVNARGTAVIGWKEHAMPAHRLVVQTLQLAPAQTTVGKAESVHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4S7</accession>
    <name>A0A1W1I4S7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47823">
        <property type="protein sequence ID" value="SLM47823"/>
        <property type="gene ID" value="NSJP_1651"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1651"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="116" mass="12802" checksum="D9765F26D98474B3" modified="2017-06-07" version="1">MSHLIVYLIGMTWICLSLACSSTRHVPQPIVDLGDGSVPIESAIVSQDLQTCRTEVHQAAPVSMQPRWLPPLGTSANGVVLGTADTPHAVWLSHEDYRQAIEHCLTDRGYRVRGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4S9</accession>
    <name>A0A1W1I4S9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48018">
        <property type="protein sequence ID" value="SLM48018"/>
        <property type="gene ID" value="NSJP_1846"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1846"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="150" mass="16206" checksum="2BB314E6C53A147C" modified="2017-06-07" version="1">MVRFPGFVPGPPIAIDDLAVTDTKNHSDGTPSGSLEGRRFLPGSPAELAEAIELAFDYRGDVTIELASGERLDGYVFNRSTDGPAPALDLFPTDAPGVRNILYSDIRSIAFSGEDTATGKSWEAWVTKKESERRAEIERVTADAKARGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4T7</accession>
    <name>A0A1W1I4T7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiol-disulfide oxidoreductase ResA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">resA</name>
        <name evidence="4" type="ORF">NSJP_1823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1823"/>
    <dbReference type="EnsemblBacteria" id="SLM47995">
        <property type="protein sequence ID" value="SLM47995"/>
        <property type="gene ID" value="NSJP_1823"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1823"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="37"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="179" mass="20065" checksum="E5B71761EF894241" modified="2017-06-07" version="1">MKRIALQVGLVVLAFAGAGPLWSDAGPVVPVAKRSLVKPGDTAPNFQLRDLEGRMMSLSDLRGKVVLINFWATWCGPCRVEMPAMEQLYRDYSRNDFEILAVSTDPQGVAVTRPFQQENRLTFPILHDAEYRIGLVYGARSLPMTFMVDRQGVVRHQIFGARDWAAPEAHQLIDLLLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4X6</accession>
    <name>A0A1W1I4X6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1896"/>
    <dbReference type="EnsemblBacteria" id="SLM48068">
        <property type="protein sequence ID" value="SLM48068"/>
        <property type="gene ID" value="NSJP_1896"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1896"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="88" mass="10071" checksum="42520C058E7A651B" modified="2017-06-07" version="1">MEKHFTVPFTVLRLLTPLKMSYEVAKKRAEPYTRIVEELPEMRRDTVELVKKAVGEKRTAYVLVNNRSEGNAPLTIQALRNALQAAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5G5</accession>
    <name>A0A1W1I5G5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">rho</name>
        <name evidence="11" type="ORF">NSJP_1999</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1999"/>
    <dbReference type="EnsemblBacteria" id="SLM48171">
        <property type="protein sequence ID" value="SLM48171"/>
        <property type="gene ID" value="NSJP_1999"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1999"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="10">
        <location>
            <begin position="56"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="174"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="186"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="423" mass="47744" checksum="038B7B1713175E2C" modified="2017-06-07" version="1">MAQTKGEVMHLAELKQKTIADLNDVARDLKIEGAANLRKQELIFAILQAQTEKNGVVFGEGVLETLPDGFGFLRAPDSNYLPGPDDIYISPSQIRRFNLRTGDIVSGQIRPPKESERYFALLKVEKVNYEDPEVARDKILFDNLTPLYPEERINLEFDREEYCTRVMDLTTPIGKGQRGLIVAAPRTGKTMLLQAIARAILKNHKEVTLIVLLIDERPEEVTDWQRQVKAEVISSTFDEPAQRHAQVAEMVLEKAKRLVEHKKDVVILLDSITRLARAYNTIAPPSGKVLSGGLDSNALQRPKRFFGAARNIENGGSLTIMATALVDTGSRMDDVIFEEFKGTGNMEVHLDRRLADKRIFPAIDISQSGTRKEELLVDKDRLNKMWILRKVLSPLGTMEAMEFLMDKVQGTKTNQEFLQSMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5T6</accession>
    <name>A0A1W1I5T6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nitrogen assimilation regulatory protein NtrX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ntrX</name>
        <name evidence="9" type="ORF">NSJP_2200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2200"/>
    <dbReference type="EnsemblBacteria" id="SLM48372">
        <property type="protein sequence ID" value="SLM48372"/>
        <property type="gene ID" value="NSJP_2200"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2200"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="140"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="469" mass="52277" checksum="814067A4015A1637" modified="2017-06-07" version="1">MSASILVVDDEEAILSSLSSILLDEGYEVAVVKSGTDALKIFTTDPPDLMLLDIWMPQMDGLETLKRVRELVPTAQVMMMSGHGSIETAVKAIKLGAYDYIEKPLSLENVTLRVKHALDQHRLEQENRSLRTKVQRRFELVGQSPAMKQLRQLIETAGPTNSRVLIGGENGTGKELVARGIHEHSARADRPFVAVNCAAIPETLIESELFGHEKGAFSGATSMKRGQFEQADGGTLFLDEIGDMSLSTQAKVLRALQEQQFNRVGGTKLMKVDVRVLAASNKDLQKEIEKSAFREDLFYRLNVVPIIVPPLRERREDIALLIRHFLKLHGEEQGLRMKEITPDAMAVFEQYEWPGNIRELGNLVERLMIIVPGSTIDAAQATMALQVRPSGSSVQTMSAGGGSGSVSALLGQPFDSLRDARNAFEKEYIGRKLREHHWNISRTAEDLKIERSHLHRKIKLLDVEMRPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5W8</accession>
    <name>A0A1W1I5W8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48375">
        <property type="protein sequence ID" value="SLM48375"/>
        <property type="gene ID" value="NSJP_2203"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2203"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="83" mass="9496" checksum="0E25D4A0E04D8BE2" modified="2017-06-07" version="1">MRKLQTSRMGVKIGSSQVMCLDSRSHLLNSMVRWTTGMLLARSYLYEFRRLNDTGQVRINLSASPKRVKTGRGSRLPPACLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5X5</accession>
    <name>A0A1W1I5X5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2240"/>
    <dbReference type="EnsemblBacteria" id="SLM48412">
        <property type="protein sequence ID" value="SLM48412"/>
        <property type="gene ID" value="NSJP_2240"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2240"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="400" mass="44432" checksum="8EA50C4D073AA7FE" modified="2017-06-07" version="1">MDTPAGKRRYLNPLGDAQDQYLFFGLFIVGAVGIWILKWSGYSQLIVTLFPVSLMLIYCIIALATKQYRIREDRAGDNVYYLGFLFTLVSLAFALHDYRLDGSGVEYILKDFGIAIFTTIFGLAGRVFFSQMREDPVEYEREARYALSEASSAMRTQLGDISTDVSSFKRKLVQIVEEGVVDITNSANAAMTETVEKHSAASIEIVKSVRETFQTFVDHSTELNDAAAKNVKALQSLFKRIEKIEAPSDMVVAKFDSVLAKFEEVAAEALKSSRTEAGQVSRLRDSIDAVVGAAETIKKSSELYETAMSQRIDKLKTAIEVLVETVASIQVSSLGLTKGLEEHQTVMSQSRSLIEDDLRVVRKHRDSITQIEGESRQSLQQLEASLVSLCKTLVEQLGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Z8</accession>
    <name>A0A1W1I5Z8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NSJP_2199</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2199"/>
    <dbReference type="EnsemblBacteria" id="SLM48371">
        <property type="protein sequence ID" value="SLM48371"/>
        <property type="gene ID" value="NSJP_2199"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2199"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF19312">
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    </dbReference>
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        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037532">
        <property type="entry name" value="STHK_NtrY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50112">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="47"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="89"/>
        </location>
    </feature>
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            <end position="135"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="434"/>
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            <end position="396"/>
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        <location>
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    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="546"/>
            <end position="756"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="PROSITE" id="PS50109"/>
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            <dbReference type="PROSITE" id="PS50112"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SLM48371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="756" mass="83971" checksum="517594370A12B6C4" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I663</accession>
    <name>A0A1W1I663_9BACT</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_2259</name>
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    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Nitrospiraceae</taxon>
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        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <dbReference type="EMBL" id="LT828648">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="SLM48431">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="388"/>
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        <location>
            <begin position="206"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="436" mass="47911" checksum="4FCA9DF18FCBF2F6" modified="2017-06-07" version="1">MLDGASQAVTQGSGEHFLSAFALLLHAGPFQLGILSALPQLIGTTAQLASVKLLRCFPDRKSLVRLGTVGQALSWIPILLLPLAFPAWGPWLLIMGAAIYFACNHFTAPTWTSFIADHLDQHERGAYFARRASIVAAVSFGALCAAGGLLSLWPRHTAWIGFVLIFLAAGTARLFSAAALRPVPDLPHREPRSGHEGFRVFLRNSSRSFRRFLLFSSLMHLAVLIAGPYFVLYMLRDLHFSYLTYGAWLAAGVLGQLLTLQGWGRFADRFGNKALLSITGFIVPILPMFYMVTTNAIFIMGVNFFSGMIWAGLALGLQNYVFDAVPEEDRATAVAVYSTLNAVGWCCGALMGSWLIAALPSRFEWAGWSWGSSLPVVFFVSGVLRLLISVGLMRQFHEPRAVEQAPLSRLLLELPLLTPVRHIQQWIASPLLRLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I673</accession>
    <name>A0A1W1I673_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Transcriptional regulator, AsnC family (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2303"/>
    <dbReference type="EnsemblBacteria" id="SLM48475">
        <property type="protein sequence ID" value="SLM48475"/>
        <property type="gene ID" value="NSJP_2303"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2303"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="2">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="137" mass="14643" checksum="CA4D85F912C1C7A8" modified="2017-06-07" version="1">MKKAKSPVATLSPAAKSPAGTLTGTRGIRYVDGEPAIPAVPCTIHAPVDGGVVMADRAYVLIHVLPGQTSSVVRALRDIKQIKTVDPCWGKPDIITVVEVADQDALTQLVLSRIHAIEGVTQTDTHLVYRLKETKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6A9</accession>
    <name>A0A1W1I6A9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4340 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2309"/>
    <dbReference type="EnsemblBacteria" id="SLM48481">
        <property type="protein sequence ID" value="SLM48481"/>
        <property type="gene ID" value="NSJP_2309"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2309"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025641">
        <property type="entry name" value="DUF4340"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14238">
        <property type="entry name" value="DUF4340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4340" evidence="1">
        <location>
            <begin position="71"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="458" mass="50579" checksum="DAE19B82264434DF" modified="2017-06-07" version="1">MRYWPTLLMALVLGGLGLYLYLVEFPAKETEERQTVEKRKVLLLDQQALTGLAIKTDQSELVFGRTGEKGWTITSPLQTDADQREVQSLIRALVTGSVHRIVEENPTTLSPFGLDSPVTTITITTGAAKETLSIGDSGPLSSTLYVLRESDHALLLTDMAPKDFVNKNLMTFRRKDILRIAKGDVDRIRLTYPTTEIVLYNVNEKPKPKWKIRYPIEAEADLNEVRMLLFRLEDLKALGIIDPGPERDTLAKTLHAPKVKVTIHAADGDQTVKLYQPDPSSGEAIAETTSDAPLYRINPTAIRDLTKELFNLQDKRLLGVDAPDIAMLSVKTATEQYVLINQSGEWVLEDRPADKVNQQTADLFVSRVVNVPAEERVMKQSGPLAPYGLVSPAAEFVATGRDGKLAGKLSLGSQSNGLAYAMGHRLQGIYQIRADLLKQIPSKKELLGSAKEGESSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6M8</accession>
    <name>A0A1W1I6M8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal large subunit pseudouridine synthase E</fullName>
            <ecNumber evidence="3">5.4.99.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rluE</name>
        <name evidence="3" type="ORF">NSJP_2494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.99.20" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2494"/>
    <dbReference type="EnsemblBacteria" id="SLM48666">
        <property type="protein sequence ID" value="SLM48666"/>
        <property type="gene ID" value="NSJP_2494"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2494"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="2">
        <location>
            <begin position="43"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="203" mass="22579" checksum="03178DADD89E18FF" modified="2017-06-07" version="1">MPKQRLPTGKLLTLAFHKPYDVLPCFTDPEGRPTLADFIHVPGVYAAGRLDKDSEGLMLLTADGGLAHRITDPTEKLPKVYLAQVERIPDEAALESLRRGVWLGDKRTRPAQVRLLPQAPSLPERPVPIRYRKNVPTSWLELTLREGMNRQVRRMTAAAGYPTLRLIRVAIGPITLDGLQAGQWRMLSPEEVAAIRQPATSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Q6</accession>
    <name>A0A1W1I6Q6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48696">
        <property type="protein sequence ID" value="SLM48696"/>
        <property type="gene ID" value="NSJP_2529"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2529"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="76" mass="8563" checksum="3E6C8EA561362BA3" modified="2017-06-07" version="1">MGHWGLVQDSVATLKLTTPRGTSPEFSLLTATYVTSHLVQNSYAPSPRVTFFHFHLWHHESLFTFGISSLPTTFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6S5</accession>
    <name>A0A1W1I6S5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Thiol:disulfide interchange protein DsbE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2459"/>
    <dbReference type="EnsemblBacteria" id="SLM48631">
        <property type="protein sequence ID" value="SLM48631"/>
        <property type="gene ID" value="NSJP_2459"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2459"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="28"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="178" mass="18883" checksum="CA3ED72813DE8C5D" modified="2017-06-07" version="1">MKRSILIVAAALAVPMLVSYGVLAAGFFKVGEKAPDFTLNALTGDTVSLASQKGKVVVLGLFHICDPCMMQGTNLQKVYESTQGKNVAVIGVNSAGNAKKDVGEFLSAFPVKVTYPYLLDPGKVTDKLYGGGKFIPNVYVIDQEGVIRWQRVGNMDLAGADVIVAEVEKLLAASGNKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6U8</accession>
    <name>A0A1W1I6U8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48737">
        <property type="protein sequence ID" value="SLM48737"/>
        <property type="gene ID" value="NSJP_2570"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2570"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021329">
        <property type="entry name" value="DUF2938"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11158">
        <property type="entry name" value="DUF2938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="169" mass="17976" checksum="5C6B0B313F5A0172" modified="2017-06-07" version="1">MTIDTLHIVGAVFVGIGAALTMDLWNLFLQRAFHISSLNFCLVGRWLSAMPTGTFTHPNIASAAKRPAECAIGWAGHFLISIAFALMLIVPTSGRWLDHPSLAPALLLGVGTVLIPYCVVQPALGLGIASANTSNPTQARLKSLMTHTAFGIGLYLSAVLWNVFRHAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I776</accession>
    <name>A0A1W1I776_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48771">
        <property type="protein sequence ID" value="SLM48771"/>
        <property type="gene ID" value="NSJP_2604"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2604"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="141" mass="16016" checksum="7B9830080A07DCA5" modified="2017-06-07" version="1">MRFMILVKATKDSEAGIMPSEQLLTEMGRFNEALVKAGVMLAGEGLQPSSKGARVKFSGDTRTVTDGPFTETKELVAGFWLWRCKSREEAIEWVTRCPNPMPGESEIEIRQVFEAEDFGAEFTPELREREERLREDIARKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7F1</accession>
    <name>A0A1W1I7F1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2770"/>
    <dbReference type="EnsemblBacteria" id="SLM48937">
        <property type="protein sequence ID" value="SLM48937"/>
        <property type="gene ID" value="NSJP_2770"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2770"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36844">
        <property type="entry name" value="PTHR36844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="65"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="478" mass="52989" checksum="92EE469ACFA73458" modified="2017-06-07" version="1">MTRSVRQSLKQEGKVVYASSAPTGVLQRKQGWSMSQPTVSPSEVLFICISGPDLGKRVSLRDGEVVIGRSSLCDVLSDDPEVAERHVTLLLKEGRVACCSVEGALFLDGHRVTDTVVIPKQQLRIGRSLWQLMVQDSPGTSRWIGDLSDRISSVAGVEKLQGFDARDMFSEVLRSRTDDEIEEYFTVGTPSTTPALEAVNTAWPKPWVFFKTFTLSAVAYLGFVFAYHEFQNANLVPGLIMTGTFLIPVSLLIFFYEMNVLRNVSLYQVVKLFLFGGITSLILSLFLFRWAHLDSWLGAMDAGLIEETGKAAALFLVVNKLKYRYTLNGLLFGAAIGAGFSAFESAGYALRLGMQSGPDAMLDNITLRGVLSMVGGHILWTAMVGAALWRVRGDRSFSIEMLRDPRFLRIFGLAVGLHMLWNSPLALPFYFKQLVLGFVSWVVNLAMIQAGLQEVRERQQAQASRVSDPPRDPRLRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7N6</accession>
    <name>A0A1W1I7N6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Molybdenum transport system permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">modB</name>
        <name evidence="10" type="ORF">NSJP_2837</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2837"/>
    <dbReference type="EnsemblBacteria" id="SLM49004">
        <property type="protein sequence ID" value="SLM49004"/>
        <property type="gene ID" value="NSJP_2837"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2837"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011867">
        <property type="entry name" value="ModB_ABC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02141">
        <property type="entry name" value="modB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="6"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM49004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="224" mass="24738" checksum="561C4AA2E216840A" modified="2017-06-07" version="1">MNWTAIWVTFKLASLTSLALLVLGLPIAYWLAYSRRRWKFLVESVVALPLVLPPTVLGFYILVAIGPHSPVGRLYTDIVGEPLPFSFQGLLLASILYSLPFAVQPFASAFGQVDRKLIEASWTLGLSRFKTFFKLIVPLSLAGLVTGVVLSFAHTLGEFGVVLMVGGNIEGVTRTISIDIYDEVQALNYAQASKTAAFLLVISYLVLLLVYAVNRNMWTAWPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7N9</accession>
    <name>A0A1W1I7N9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48941">
        <property type="protein sequence ID" value="SLM48941"/>
        <property type="gene ID" value="NSJP_2774"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2774"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="63" mass="6810" checksum="ED7FF2A3EE42E253" modified="2017-06-07" version="1">MTWPETSAWSSASSISSKGMVKVGDGKGSWIWAIDGPEQHMMNAVVVRKVRMIAPYDGSKIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7P2</accession>
    <name>A0A1W1I7P2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pgm</name>
        <name evidence="14" type="ORF">NSJP_2853</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2853"/>
    <dbReference type="EnsemblBacteria" id="SLM49020">
        <property type="protein sequence ID" value="SLM49020"/>
        <property type="gene ID" value="NSJP_2853"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2853"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05801">
        <property type="entry name" value="PGM_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005852">
        <property type="entry name" value="PGM_a-D-Glc-sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PTHR22573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01132">
        <property type="entry name" value="pgm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="11">
        <location>
            <begin position="41"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="12">
        <location>
            <begin position="211"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="13">
        <location>
            <begin position="322"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="10">
        <location>
            <begin position="481"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM49020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="548" mass="59080" checksum="BDE76E381A960AFB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7R5</accession>
    <name>A0A1W1I7R5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha amylase, catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2858"/>
    <dbReference type="EnsemblBacteria" id="SLM49025">
        <property type="protein sequence ID" value="SLM49025"/>
        <property type="gene ID" value="NSJP_2858"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2858"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
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        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="15"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="490" mass="55919" checksum="1138A7A2FEEBDC52" modified="2017-06-07" version="1">MKGGWPKRPVIYEINTWVWLYELSRKYGKTVTLATVPDAEWDAIGAYGFDAVWFMGVWERSPAGIAISMKNNGLLEDFRRALPDFAPQDNVGSPYCVRRYVVDAQLGGPQGLASARKKLAARGLRLILDFVPNHVAPDHPWVNDHPEYFIQGTDDDAARQPDDFIRVGGRVLACGRDPYFPAWPDVLQLNAFAPGLRTAAIDTVDSIADQCDGMRCDMAMLLMNPIFERTWGARAGVKPATDYWPEVISAVRKRHAQVLFIAEAYWDLEWDLQQQGFDYCYDKRLYDRLEHNAAETVRLHLCADLPYQERLVRFIENHDEPRASAAFEAGRVAAAALTAAALPGAKLFHEGQFEGRRVRLPVFLRRRLDEPADERLRSFYRTLLRFLGTDDLRSGEWSLCERRGWPDNQTFMNLLAWCWRKGDKRHLIAANLSPADAQAEVMLPWNDLGGRSWRLADVISGEVFDRQGDQLTKSGLYVDLDPWKFHVLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7U0</accession>
    <name>A0A1W1I7U0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49118">
        <property type="protein sequence ID" value="SLM49118"/>
        <property type="gene ID" value="NSJP_2951"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2951"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="208" mass="22438" checksum="A3E497600EFA9FA5" modified="2017-06-07" version="1">MCRHSLIDRFRCEATRLVIATVLVVLGGFGTPAPAIDVAPTNEQIRAALDRGKDAAQQHEPPDSFYVRFGSTDALHPSGFLITKLGSLSVMATHMALRGLEPSDADILQVLETKTMLVSTVIFGNVPTFAADSYMVFDQGGHTIKPATVRFDGQGSRSAAWPESPRFKAKVIASFNYADFDPKAPTTLTVFPANGGEVSFALDFSQFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I849</accession>
    <name>A0A1W1I849_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49187">
        <property type="protein sequence ID" value="SLM49187"/>
        <property type="gene ID" value="NSJP_3020"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3020"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="SSF50405"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012641932" evidence="1">
        <location>
            <begin position="25"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="410" mass="43780" checksum="982759D31B07194D" modified="2017-06-07" version="1">MNTRSLVTRLLYGACLLAFGCATAEPVPKERGQASISQMDVPVIPDEQPAITEVPAETGEVQERGITRLNPAVLEGKTAVLGTLSTGLTSTYPGEFAFRTSKGYYLTAINGGGRIGDPTVITGATSAGAWEKFKFAIASPPSPYDKTFQTANGNYVTAVNGGGMTANAIHTDATQPRDWERFRLVYMSGHPPTYYGIGTIKGNFLTAVGAGGKYQDALHTDAKQIQAWEQFRIVKCGDPGSGYEYAIMAADGEFLASNNWEGKPGFGLSARPAEAEMKFKLFRQSDGTYALQTANGRTYLTALGGGGQVEKYDRKYYTPDCGGLFGGPCVGGSAPIFHTDATQVQAWEKFRIIDQGNCTYAIQTSSGFFSGIFKDSSGVTLLTTRRDGAPSANEKFQLVVFGLASPAIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I892</accession>
    <name>A0A1W1I892_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Response regulator, CheY like (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49141">
        <property type="protein sequence ID" value="SLM49141"/>
        <property type="gene ID" value="NSJP_2974"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2974"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="379" mass="41555" checksum="75358A63435164F4" modified="2017-06-07" version="1">MPSTIYIIDSSPAVRRMVEQISTPEGYEVIGFQDGPTALEAARKQGPTLIIADYHLDNMTFSGFCKEVHKLDTLSETLIISLVGAADRLDESHLRALGVKAFLKKPFQTEHLLDLIKDLDRSTPAQANGAKKKRRAWPPVSSATDSDDDEADTLGDYDQTGEIEAQVIPPPSQKEPVMASTVPTKPPAAEPEDAIKGLFGQLMQSMTEKAEKKITEVLPDMIAKDLAVQVSKAVEVETRQHVGATLTQERLAEFLEPVLKKELPNILVREFPAIEPILRSGIVEFATPLIKDQIDLLAKEQAEAIKAAVPAAVREHLKSIDDEIAREIRKAATEKAEALAEDLVRTAANNQVQQTVLELVPGIAEEQVKNELKRLTEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8A1</accession>
    <name>A0A1W1I8A1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Polysaccharide export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3080"/>
    <dbReference type="EnsemblBacteria" id="SLM49247">
        <property type="protein sequence ID" value="SLM49247"/>
        <property type="gene ID" value="NSJP_3080"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3080"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="132"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="226" mass="24550" checksum="200BC8D673ACECBA" modified="2017-06-07" version="1">MRIYSSHIILGFSILIFINPAPSTAEQNILEKQLAPMATGGPGANEKSLLVVTPEYIVGPEDILEITVWKNPELSKEVQVRPDGRISLPLLGDLSAVGKTPVQLTDEISAGLKKYMEHPTISMTVKDVQSYQIYVLGEVNRPGKYPLKSKTTLLQGITVAGGFTGVAAKNSIVIFRFTKDGQGQAKLKASYDDIVVRDGSGQNIELMPGDMIVIPSETMVVLPRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8E3</accession>
    <name>A0A1W1I8E3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49292">
        <property type="protein sequence ID" value="SLM49292"/>
        <property type="gene ID" value="NSJP_3125"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3125"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014917">
        <property type="entry name" value="DUF1800"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08811">
        <property type="entry name" value="DUF1800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="727" mass="79393" checksum="8D26CB14F9D4FB6A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8I6</accession>
    <name>A0A1W1I8I6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49358">
        <property type="protein sequence ID" value="SLM49358"/>
        <property type="gene ID" value="NSJP_3191"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3191"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025578">
        <property type="entry name" value="DUF4359"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14271">
        <property type="entry name" value="DUF4359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="124" mass="13884" checksum="8C5D210751EB476A" modified="2017-06-07" version="1">MKIWPLILLVTSLAASIALVLTNPSMDDYVTFVEAELGKALDRHEASAAPNREREVVRTIFRAHSRELVESVVRPHTVQRNWGLFGFFETTALEVHIEVLGLGGRFFPLKGIDDAVVRLGRLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8S8</accession>
    <name>A0A1W1I8S8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49400">
        <property type="protein sequence ID" value="SLM49400"/>
        <property type="gene ID" value="NSJP_3233"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3233"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012529060" evidence="1">
        <location>
            <begin position="24"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="389" mass="42710" checksum="ECB6CFAC4C6B0B54" modified="2017-06-07" version="1">MKPIRLLSLTLGLLLSCASLASAELLALLNYESKPDQPVRREGIAIMEIDPESQDFGKILMEIPLPSDLVAHHIFFNRDRTKAYVTALGKSLLHVVDLTKFPYRLRAIEVPDCKVGEDLVVSEDNKTWYLTCMGSSNVIMGDAVKDKPIKTLSSTDPAAFVLYPHGIAIHNGIDRVLVTSTVKPDMSEQGETVSVLEASTGKVLSTHKLSSKPSTKSAPVEIMFSPNTNPPVVHITNMLEATLWAGIWDPKTKTFSFHQVDDFGPRDQGMPLEMMYNAKGDRLYVTTAKPGFVNLYDNSDPAHPKFLKAIPAAAGAHHTVLSPDERYLFVQNSLLNLEGMSDGSITVIDLKNDKVLGSIDTLKAAGFNPNCIMPLPNHFRDAKTQVSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8X8</accession>
    <name>A0A1W1I8X8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49464">
        <property type="protein sequence ID" value="SLM49464"/>
        <property type="gene ID" value="NSJP_3297"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3297"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="57" mass="6177" checksum="2799AF8F2EDEB94D" modified="2017-06-07" version="1">MSLVYWGIVTGLVLMVVTLFVSFALIGSKARPSDASRQSLEELKEHIARASSGRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I906</accession>
    <name>A0A1W1I906_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49482">
        <property type="protein sequence ID" value="SLM49482"/>
        <property type="gene ID" value="NSJP_3315"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3315"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="129" mass="14650" checksum="7BCB7A9172709610" modified="2017-06-07" version="1">MPNTNASFAPRMRSEELQALIEKLETLDHRSPVRPDLERFDDEAEAVLVRLYGADHRYVETYKYATLAEAEALVNLPESAQEPMAKDLPKTAVQQRRQALQSMLTEMAEMEAKEVTMLTGEDKEDPPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I911</accession>
    <name>A0A1W1I911_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative fatty acid cis/trans isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49486">
        <property type="protein sequence ID" value="SLM49486"/>
        <property type="gene ID" value="NSJP_3319"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3319"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010706">
        <property type="entry name" value="Fatty_acid_cis-trans_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06934">
        <property type="entry name" value="CTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="787" mass="90087" checksum="D0CE5D109223FC67" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I938</accession>
    <name>A0A1W1I938_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">tatC</name>
        <name evidence="6" type="ORF">NSJP_3371</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a complex with TatA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3371"/>
    <dbReference type="EnsemblBacteria" id="SLM49538">
        <property type="protein sequence ID" value="SLM49538"/>
        <property type="gene ID" value="NSJP_3371"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3371"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="256" mass="27983" checksum="C28402F7F556ED51" modified="2017-06-07" version="1">MAPSIHPLAAHIQTVKRRLLIIGATILVALAVAFTFSAEMVAWLNRPFPDQLVFYGPTEALFASIKVSFLAAILASLPVVFYQFWKFVEPALLPKEQRWGIPIFLLAGALFALGLIFCNLVILPLVIDFFVSFGMDRDITPQLSVGTYIDFNVKFLLTFGCAFELPLILTILARVGVVSAQVLAAYRKHAILGSLIISAIVTPDATLFTMLLMAVPLMILYEVGIIGAKIFGRAPTDMDLPLDPDLPVGTAGHRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I964</accession>
    <name>A0A1W1I964_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3365"/>
    <dbReference type="EnsemblBacteria" id="SLM49532">
        <property type="protein sequence ID" value="SLM49532"/>
        <property type="gene ID" value="NSJP_3365"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3365"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="78"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="300" mass="34281" checksum="40D0DAA8AF7E40B1" modified="2017-06-07" version="1">MAQATTSWTIEDDGAARTLTIGTRRVTTSYSTKLIELLIARKGPERASQFLVHRTDRAWFLAPLFDVLNRTRTGLNVLEVGCSAGHLTEYLNEQPCIDSIHSFDVDKAFVDVVRLKQHELGLRKVKCVDHFSIRSTQALPYEDDYFDLVIVAAVVEHLPFENRHLYVDEYYRVLKEGGLVGFWDTPNRWYPMESHSIGLPFISLLPPPVAYAYARLFKREKMRDVGFPLFVRAGTGWRNSSYHELLPQSVMADVEDVSNGFGYQPGAGRWGRIFAQLLKVPPAFFAPSFNLVFKKVRQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9C7</accession>
    <name>A0A1W1I9C7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49531">
        <property type="protein sequence ID" value="SLM49531"/>
        <property type="gene ID" value="NSJP_3364"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3364"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="252" mass="26061" checksum="BC964D32E5B1983A" modified="2017-06-07" version="1">MQQLVYRPLISLFILVCLLTLYGCGEQDQPATTQTSSAEGFWTGNTNTNRTLTGVVLDDGTYYFFYSAASAPAQVAGVIQGTGTSSDGTFTSGNAKDFRIGASALDATITGTYGNRSFLNATITYTGGAVVTFTSSFNTVYNSNPTLAAVSGFYTGQAGSSNGVQTGNINVTASGPFAGAETNGCAFTGTATPRIRGNAFNQTTTFGGLPCFFAGSTFQGIALFDLGTLRLMSAAPNGTRTDAAIFSGLRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9H4</accession>
    <name>A0A1W1I9H4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Threonine-phosphate decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.81</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">L-threonine-O-3-phosphate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cobD</name>
        <name evidence="11" type="ORF">NSJP_3531</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + O-phospho-L-threonine = (R)-1-aminopropan-2-yl phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:11492"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58563"/>
            <dbReference type="ChEBI" id="CHEBI:58675"/>
            <dbReference type="EC" id="4.1.1.81"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.81" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3531"/>
    <dbReference type="EnsemblBacteria" id="SLM49698">
        <property type="protein sequence ID" value="SLM49698"/>
        <property type="gene ID" value="NSJP_3531"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3531"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005860">
        <property type="entry name" value="CobD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01140">
        <property type="entry name" value="L_thr_O3P_dcar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="10">
        <location>
            <begin position="28"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM49698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="372" mass="40998" checksum="D00D5584471A8520" modified="2017-06-07" version="1">MALKAADTHGGNIHAVAMELGRRASSLLDFSASINPLGPSSKVRRLLAREAEGLIRHYPDPECGNLRRALASRWRLSPRHFVIGNGSIELIHLLPRVLQCRSALIVGPTFSEYGAALSLAGAQAQLLSARKRDGYRPPLDKAGKWIQSAARRAQGASAVFLCNPNSPTGQACEPGDLEELVRQAGQSGVWMILDETFMEYCESLSLLPVLHRYPRLIVLRSFTKFYGLPGLRIGYGVCAPSLAEVLRRHQPPWSVNGYAQAAAETAMNDRPYVRRSLAFMEAERERVSMRLSGIPGLRVFPSRANFLLLELPDLHQASGVAAVLRQQGLLVRDCSRVPGLTTRSIRVAIRTEPENDRMVVALRRLLGTGRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9R7</accession>
    <name>A0A1W1I9R7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="6 8">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 13" type="primary">glmM</name>
        <name evidence="13" type="ORF">NSJP_3568</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="6 8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3568"/>
    <dbReference type="EnsemblBacteria" id="SLM49735">
        <property type="protein sequence ID" value="SLM49735"/>
        <property type="gene ID" value="NSJP_3568"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3568"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05802">
        <property type="entry name" value="GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_B">
        <property type="entry name" value="GlmM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006352">
        <property type="entry name" value="GlmM_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01455">
        <property type="entry name" value="glmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="159"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="260"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="376"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="6">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="6">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM49735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="449" mass="48597" checksum="12D3F877D680F074" modified="2017-06-07" version="1">MRKLFGTDGVRGVANLEPMTSETAMQLGRAAAHLFMRRAGRHQIVIGKDTRVSGYMLESALTSGICSMGVDVLLVGPMPTPAIAFLTRSLRADAGVMISASHNPYQDNGIKFFSNDGLKLPDDMEARIEQLILSNEIAHLRPTADAIGKAFRIDDAEGRYIEFVKRSLPKELDFQGIKLVVDCANGAAYKVAPTVLRELGAKVEVIGNKPDGMNINAGCGAVHPDSLRQAVLQYGADLGVALDGDADRAIFVCEQGKVIDGDHIMAALSLDLHRHGALAKKTVVGTVMSNFGLEKAMAQAGITLIRTAVGDRYLLERMLADGYNFGGEQSGHFIFLDHNTTGDGLISALQVLSLMKRTQRPLSELAKAMTAVPQVLLNVKVSKKPELDSIPELQRAIGESEQKLNGNGRILVRYSGTEPLLRIMIEGEQDGFIRQEADRLAQMVKTHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9T0</accession>
    <name>A0A1W1I9T0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Molybdenum cofactor biosynthesis protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">moaB</name>
        <name evidence="7" type="ORF">NSJP_3607</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May be involved in the biosynthesis of molybdopterin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3607"/>
    <dbReference type="EnsemblBacteria" id="SLM49774">
        <property type="protein sequence ID" value="SLM49774"/>
        <property type="gene ID" value="NSJP_3607"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3607"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012245">
        <property type="entry name" value="MoaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43232">
        <property type="entry name" value="PTHR43232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006443">
        <property type="entry name" value="MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="6">
        <location>
            <begin position="20"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR006443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="170" mass="18732" checksum="109551CF2A2115BA" modified="2017-06-07" version="1">MTSHAAHEHKSEAPSQIGCMVITCSDTRTRDTDTSGRRIMHLLKDAGHTIVDYYIVKDEPAKIKAKIKAGTANKRIHAIIINGGTGISRRDSTFEAVDGMLEKRLDGFGEVFRYLTYQEIGSPAIMSRATAGIIKGRVLFSTPGSENAVRLAMEKLILPELGHILQQLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9U5</accession>
    <name>A0A1W1I9U5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3651"/>
    <dbReference type="EnsemblBacteria" id="SLM49818">
        <property type="protein sequence ID" value="SLM49818"/>
        <property type="gene ID" value="NSJP_3651"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3651"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="772" mass="81110" checksum="79397EE6C5DBC78C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9W3</accession>
    <name>A0A1W1I9W3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Na(+)/H(+) antiporter NhaS5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49838">
        <property type="protein sequence ID" value="SLM49838"/>
        <property type="gene ID" value="NSJP_3671"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3671"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="6">
        <location>
            <begin position="88"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="481" mass="51420" checksum="28C5CBE7125F8278" modified="2017-06-07" version="1">MADETTDSGTTNKLPTHAAAGVPSSPNSHISPSTTIAGRLANAVVGLTLWDGLIILSIIIALGAFLVEWQRGLVMEYFRQGRPFDRFAVVLIALVFLPQQFERIKLPGMLGLILGGVLLGPYGLALILKVGEVGQFFSELGRVFLMFVCGLEINLSDFRRYARPSTLFGIATFLGPMIGGFALGLTFGYGINASVLIGSLLASHTLLGFPIIDKLGLLRQPFALTTIGATIFTDIAALLVLAVCLSVHMSGVLDWGALFGLFGSLAVYSVFVMGAIPRIGNYYFRIHHADEIGQFQFILAVIVICAVGAKLIGLEDIVGAFLCGIAVNQVLHHGAAREKIEFLGKGLFIPAFLMAVGATLDLPAFFRTFSTGLSFVIGIIIVLCLGKFAAAYLTGWVYRYGRAERLSMWALSLPQLAATLAATVTAYNSINAAGERLIGEQVVNAVIVLMVLTATLGPVLTEWFGRQVPRDSVSDSSPSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9W7</accession>
    <name>A0A1W1I9W7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49790">
        <property type="protein sequence ID" value="SLM49790"/>
        <property type="gene ID" value="NSJP_3623"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3623"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014910">
        <property type="entry name" value="YdhR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08803">
        <property type="entry name" value="ydhR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="99" mass="11268" checksum="82831865CE2F9CA4" modified="2017-06-07" version="1">MIAVMVRFQYDTEFNEAHLQQIAEGARSKFQGMPGLRSKAFTVDAARRQALNFYMWESEDAARKFFSPQMIDAVAKIYGVRPSIDYLKLATLVENPSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA02</accession>
    <name>A0A1W1IA02_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49878">
        <property type="protein sequence ID" value="SLM49878"/>
        <property type="gene ID" value="NSJP_3711"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3711"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="159" mass="17765" checksum="7B930D3203E9ACFC" modified="2017-06-07" version="1">MGQIRLRPDRTARTARLSASIIVWLACTMGCDGNRATGPAFEDVLHLGPETALLYFYRPPVPDGDQAPQWVYAFDQIIRLDDGGYSFHAVPPGRYLISLRSQSDPTADWYDLAAGRATFLKWNRAKAGGQPTLIPVDERRAIEELPQCRLMQHDPSGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA14</accession>
    <name>A0A1W1IA14_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">alr</name>
        <name evidence="7" type="ORF">NSJP_3594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3594"/>
    <dbReference type="EnsemblBacteria" id="SLM49761">
        <property type="protein sequence ID" value="SLM49761"/>
        <property type="gene ID" value="NSJP_3594"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3594"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="241"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="370" mass="39824" checksum="AA571454E82E279E" modified="2017-06-07" version="1">MLTTYAHIDLAALVHNLTQIRRYLSGNAAVLAVIKANAYGHGAEEMAKTLVRHGVSHLGVVSVTEGRALRESGITTDIIVLGPTFDEQLPDALHSRLTLVVGDRPRLTALARAAAEKGLSVPVHLKVETGMGRLGFSVDEMPVVLDSLRNHSSLRVEGLMTHLSDADGKTSDYTEQQLATFHQTLELLAARGLHPPLIHAANSAAIVRYPTSHFSLVRPGIMLYGYHTLPGSVPAPSLKPVMTLRTTIAHLRTVKPETSISYNRTFVAARPSTIAVLPIGYADGYSRRLSNRGAVLIHGQRAPIVGTICMDMTMVDVTDIPAAQVGDQVIIIGHQGRDTIGADEIAEWTATIPYEVLCGIGPRVPRIYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA44</accession>
    <name>A0A1W1IA44_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49862">
        <property type="protein sequence ID" value="SLM49862"/>
        <property type="gene ID" value="NSJP_3695"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3695"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="59" mass="6897" checksum="5CA710C687BE494D" modified="2017-06-07" version="1">MRAERDMIHFVHHPRTATVKNASADRLGEPRSLYTAFYFPFSERANIRFDTTAEPNLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA67</accession>
    <name>A0A1W1IA67_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">proA</name>
        <name evidence="9" type="ORF">NSJP_3729</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3729"/>
    <dbReference type="EnsemblBacteria" id="SLM49896">
        <property type="protein sequence ID" value="SLM49896"/>
        <property type="gene ID" value="NSJP_3729"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3729"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="85"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="454" mass="48762" checksum="BCC9E95F7C221A1C" modified="2017-06-07" version="1">MPEVPVKIYVDKLLKEIRKMAPPVALLPGPVKDKAIRAMADRIEADAEAILAANDRDVDALGKSFEGESNKDPLKAAVARVRIQADDIKEMAERLRTIADSADPVGAVTAKWERPDGLQVSRVRVPIGVIGVISERKPLVTVESIALCLKAGNPCIFRGAPEWALTHEVIGKGLKEAAQGEGVPAGAWVLVERQEKEVAVELIRAGKHLDAIIPRGGPGLRKAVLDGARMPVLCHDGGLNHLYVDADTDIPMAQNIAINSKAQLAGASNALDTLLVQQVVARQFLAALINRLLDEFKIEVRGCPKTIALMGQMAMSGHTSIKPAAEEDWTTQFERRLLAVKMVTGLDEALQHIAQHGPVLTAVIATTNYASAMRFTREVDAASVMVNASSRLNAGDGFGLGADIGLSTSRLHAKGPVGLEQLTCEKYVTFGSGQLRLPHPVPEAYFDAIMLKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAB8</accession>
    <name>A0A1W1IAB8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49713">
        <property type="protein sequence ID" value="SLM49713"/>
        <property type="gene ID" value="NSJP_3546"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3546"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="64" mass="7066" checksum="88522250E6888642" modified="2017-06-07" version="1">MMKLSEHPALILHGILEAHPDLREGEEIDLDIIGLVVQCCEPEPPRRNTFDCAENGAFAGPVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAE4</accession>
    <name>A0A1W1IAE4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Response regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_3827</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3827"/>
    <dbReference type="EnsemblBacteria" id="SLM49994">
        <property type="protein sequence ID" value="SLM49994"/>
        <property type="gene ID" value="NSJP_3827"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3827"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="11"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="159"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="234" mass="25338" checksum="B8302A609908AEBD" modified="2017-06-07" version="1">MTQISKGVLVKALILSDNHITRSGLRRILESHTGFQVLGEGSVGSTNIVESLVRQHPEVILLDLDPNGIDALGFLRNLERLTRSSSVIILCDLGNDELARKALALGAAGIVLKMQPPSALIAVIQSLSGSGKEDFESRRPVKQTDAVGSTGPTHHASHTVDRIGSLTTREREIIRLIAAGLKNKEVASRLRISDITVRHHLTSIFSKLDVSDRQKLLILAHEHGLVELALSQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAF6</accession>
    <name>A0A1W1IAF6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3819"/>
    <dbReference type="EnsemblBacteria" id="SLM49986">
        <property type="protein sequence ID" value="SLM49986"/>
        <property type="gene ID" value="NSJP_3819"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3819"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="331" mass="37082" checksum="19CD3BC3CDB1E989" modified="2017-06-07" version="1">MANKFVVGDWVEVKSAGEILGTLDNRGTLDGMPFMPEMLACIGKRFRICKRATKTCDTIDKAGFRRVKETVLLDGVRCSGMDHGGCQAGCMIFWKEQWIKPALAPGQSAAIAIETQGRGNGNGSLPRDPDFVRLEARVRKAACADDTPGMGGEPVYMCLITEMKRASLSMAWWDLRHFVADIRSGNRRIMEVVRALLLGLFSWVQDKRGGACYPSMEGGPLKKTPNDDLRLQPGDLVKVRPPQEIVNTLDANCRTRGLRFDVGMFRYCEGEYRVAIRALRLIDQRTGKMIHMADQSPCILLDGATCHGDFMKLCPRSEYVFWREAWLERVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAG3</accession>
    <name>A0A1W1IAG3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_3815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3815"/>
    <dbReference type="EnsemblBacteria" id="SLM49982">
        <property type="protein sequence ID" value="SLM49982"/>
        <property type="gene ID" value="NSJP_3815"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3815"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032610">
        <property type="entry name" value="DUF2172"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032589">
        <property type="entry name" value="DUF4910"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012353">
        <property type="entry name" value="UCP015244"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032622">
        <property type="entry name" value="UCP01524_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09940">
        <property type="entry name" value="DUF2172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16254">
        <property type="entry name" value="DUF4910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16221">
        <property type="entry name" value="HTH_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015244">
        <property type="entry name" value="UCP015244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DUF4910" evidence="4">
        <location>
            <begin position="37"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2172" evidence="2">
        <location>
            <begin position="86"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_47" evidence="3">
        <location>
            <begin position="375"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015244-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="454" mass="50995" checksum="F5B0A5CBA1112409" modified="2017-06-07" version="1">MNSQSMDGSFTLSSELPQVSQLRQALDQRELGRALMELITELYPLCRSLTGNGVRQTLSIIGRNVPLQIHEVPSGTQVFDWNVPKEWNITDAYIKNAKGERVVDFRKSNLHVWGYSIPVRATLSLADLKPHLYTLPEHPDWVPLRTSYYKPDWGFSLSHNQYLSLDDGEYEVCIDSTLADGHLTYGEYYLPGDQPDEVLISTHVCHPSMCNDNLSGIAISCFLARALTESSRRYSYRFLFIPVQIGSITWLARNEAIVPRIKHGLVLTALGDAGFSTYKKSRQGTAEIDRAAVHVLRHSGLPHEVLDFYPHGYDERQYCSPGFNLPVGNLRRAPSGRFPEYHTSADNLQCVKPESLSDSYVKCLDILSILEANKTYQNLNPKCEPQLGKRGLYRMTSDLNGVGKVKELPVLWVLNQSDGMHSLLDIAEMSGFSFDEIKQAADSLTACGLVKVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAH0</accession>
    <name>A0A1W1IAH0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3702"/>
    <dbReference type="EnsemblBacteria" id="SLM49869">
        <property type="protein sequence ID" value="SLM49869"/>
        <property type="gene ID" value="NSJP_3702"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3702"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="138" mass="15531" checksum="57E1AF708FA9EACD" modified="2017-06-07" version="1">MTHQCMSSKINAHTMARLVSCLWLGLGLLLTGCESERSRLMTEKYPTYPDDIKRAIDRGYPVRGMNHDQIYLAFGEPICKKAIEHKGRPVEVWLYPPGGRDPCLTAEFRVYFENGAVSDWAKMTEASRFADPPGGLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAT8</accession>
    <name>A0A1W1IAT8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50031">
        <property type="protein sequence ID" value="SLM50031"/>
        <property type="gene ID" value="NSJP_3864"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3864"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="106" mass="11638" checksum="5E9FDE275C3EC1C5" modified="2017-06-07" version="1">MRPRLTTTAPAMGFGLVVPRPFSARRSARDMYRSSSAGLTRMADEDTRVNQATLPFNHATDHRVFLRAVLRAVWERREDRAALFGFARDAAEGLAAFLASASANAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBC2</accession>
    <name>A0A1W1IBC2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rfbD</name>
        <name evidence="4" type="ORF">NSJP_4123</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4123"/>
    <dbReference type="EnsemblBacteria" id="SLM50290">
        <property type="protein sequence ID" value="SLM50290"/>
        <property type="gene ID" value="NSJP_4123"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4123"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="5"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="293" mass="31725" checksum="96B6675FB05B2C51" modified="2017-06-07" version="1">MPETRILITGAQGQLGCALRSVLPPETLILKDLPEFDLTAASCEEQIVQARPHVVVHAAAYTNVDGAEREPDRARAVNVEGTAAVARAAQRVGGRLIYISTDYVFDGAKDTPYTEEDPTNPLNMYGRSKRDGEAAAAEHCEDCLVVRTAWLYGHGGKNFVKTIMQLAGERPVLEVVADQRGCPTFADDLARALVDLIPSRLTGICHVTNSGSSTWYEFADTIVRLIGSATVVRPIPTTQSQRPATRPPYSVLAYGRLGLVRAPLPDWRDALDRFTRQIRSSASTIPSSGAAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBG8</accession>
    <name>A0A1W1IBG8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_4158</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4158"/>
    <dbReference type="EnsemblBacteria" id="SLM50325">
        <property type="protein sequence ID" value="SLM50325"/>
        <property type="gene ID" value="NSJP_4158"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4158"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="38"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM50325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="291" mass="32131" checksum="8974A99990572419" modified="2017-06-07" version="1">MTQTSMPLSIGPARSPTVRRELRGTGGLVETLFDRRRLVWQMAKREVRDRYAGQALGTLWAVAHPILLMGLYLFLFTFVFPSRVPFGGGQGSAVTYILAGLIPWLTVADAMSRGTGAIVNEAGLVKQVVFPVEILPIKSVLASGLPQGIATFVLLLYMAAVDRHVPLLAAMLPLLFLLQLMVMAGLVYVLSSVGAYVRDLREIVQVFVSAGVFVAPILYSEESIERTVPGFASLLSLNPFSHLVWCYQDALYYGRFVHPVSWLLLLLLSPAVLFLGYRVFRKLKLMFGEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBP7</accession>
    <name>A0A1W1IBP7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_4142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4142"/>
    <dbReference type="EnsemblBacteria" id="SLM50309">
        <property type="protein sequence ID" value="SLM50309"/>
        <property type="gene ID" value="NSJP_4142"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4142"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03360">
        <property type="entry name" value="LbH_AT_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020019">
        <property type="entry name" value="Sia_OAcTrfase_NeuD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="220" mass="24059" checksum="E2AEF0A5435404F7" modified="2017-06-07" version="1">MTKQAVIFGTGSLAEVIDFYLAHDSPYRVAAFTATGDFVGQPQFLGRPLVAFEEVETRFPPDTYEMFVAVGYRHLNRLREQYCSAARTKGYKLLTYLSSKATHWGDTMLGDNVFIFEDNTIQPFVKIGNGAILWSGNHIGHHSSIGPSCFISSHVVVSGHCTVGDRCFIGVNATITDSVVVGNDNIIGPGALIQKSTSDGEVHVAERAKKLPKDSSKFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBY8</accession>
    <name>A0A1W1IBY8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative periplasmic serine endoprotease DegP-like</fullName>
            <ecNumber evidence="8">3.4.21.107</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_4116</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.107" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4116"/>
    <dbReference type="EnsemblBacteria" id="SLM50283">
        <property type="protein sequence ID" value="SLM50283"/>
        <property type="gene ID" value="NSJP_4116"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4116"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011782">
        <property type="entry name" value="Pept_S1C_Do"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02037">
        <property type="entry name" value="degP_htrA_DO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="291"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="421"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR611782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM50283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="507" mass="53786" checksum="1F0DB1D04AD17470" modified="2017-06-07" version="1">MKLSRSWALSFALVAVGIVIGVGIASDLGWLPNGSAGPEQTPTPDPIVRPVATAPQPVMPGASAKNFVEIAKMVKPAVVNIAATRNGKPGDGPHGTPFDDPFFRRFFGDEFFKRETPPRDRKERGQGSGVIVDTNGIIITNNHVVSKADEIRVFLSDKREFKGKLIGTDAKTDIAVVKIEATGLPAVPFADSDQLEVGEFVLAVGSPFGLTQSVTMGIVSAVGRASMGIAEYEDFIQTDAAINPGNSGGALVNIRGELVGINTAIFSQSGGNMGIGFAVPSNLSRSIMDQLLKSGKVVRGWLGVAIQELTPELASQFGIGDTKGVLVSDVMEDSPAKKAGFERADVIVEYDGKPMDSPTHLRNAVAQTPIGRKVTVKLIRDKKPKTLDLTIVEQPKSMSLPGSDDGGESASPSGVLSDIDVRELNEDLAGRYGLKPSERGLVVTRVKPDTPAEQAGVREGDVILEVNRKAVNSIKSYERAAASLAKDQSVLVLLKRKGQTIYLTLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZN4</accession>
    <name>A0A1W1HZN4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46201">
        <property type="protein sequence ID" value="SLM46201"/>
        <property type="gene ID" value="NSJP_0029"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0029"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012777296" evidence="2">
        <location>
            <begin position="24"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="122" mass="12753" checksum="8C3A6CB252070723" modified="2017-06-07" version="1">MSHWAISIVLTVSLLLAAAPASAQTSGSHPPANAAGILNALPPDLYMKLERLAQLLDQNIKAGKLTDAQLQQELMSGRLEQTIRGLGSEANQLLEEIQSDMQNGKGPGESALMPLLGGLGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZT4</accession>
    <name>A0A1W1HZT4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">K(+)-insensitive pyrophosphate-energized proton pump</fullName>
            <ecNumber evidence="9">7.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Membrane-bound proton-translocating pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate-energized inorganic pyrophosphatase</fullName>
            <shortName evidence="9">H(+)-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">hppA</name>
        <name evidence="10" type="ORF">NSJP_0098</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphosphate + H(+)(in) + H2O = 2 H(+)(out) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="7.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0098"/>
    <dbReference type="EnsemblBacteria" id="SLM46270">
        <property type="protein sequence ID" value="SLM46270"/>
        <property type="gene ID" value="NSJP_0098"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0098"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="586"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="664"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="site" description="Determinant of potassium independence" evidence="9">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM46270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="685" mass="69709" checksum="5011F6E0FF496FD7" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZU0</accession>
    <name>A0A1W1HZU0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative N-carbamoyl-D-amino acid hydrolase</fullName>
            <ecNumber evidence="2">3.5.1.77</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.77" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0082"/>
    <dbReference type="EnsemblBacteria" id="SLM46254">
        <property type="protein sequence ID" value="SLM46254"/>
        <property type="gene ID" value="NSJP_0082"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0082"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047417">
        <property type="term" value="F:N-carbamoyl-D-amino acid hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="262" mass="29079" checksum="672A4DEE7D83CA56" modified="2017-06-07" version="1">MRIGYYQSNPEFGETSANLERISAQLDAIEADLIVLPELCVSGYQFVSQSEVRNLAESIPDGPTTARLIEIARKKHMVIVAGLAERAGSLLYNSAVAVGPTGFIGAYRKTHLFSEETLFFTPGDTGFRVWDIGPARIGVMICFDWYYPESARALALRGADIICHPSNLVLPNCPDSMPVRCLENRVFSVTCNRTGMESRGGKAPLVYIGNSEIVNPRGEILCRSPRDREDVCIIEIDPSEARDKAVTPYNDLLRDRRDSLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZW9</accession>
    <name>A0A1W1HZW9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Phosphatidylinositol alpha-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.57</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.57" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0007"/>
    <dbReference type="EnsemblBacteria" id="SLM46179">
        <property type="protein sequence ID" value="SLM46179"/>
        <property type="gene ID" value="NSJP_0007"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0007"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="12"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="178"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="382" mass="41860" checksum="FA3119AED7760603" modified="2017-06-07" version="1">MNLFISESSTAVGGQELAVLLHAEGLVKRGHRLRLILEPGSPIAAMAQEKGLPVTLLSMRRNRYPQAIVALRGLMYRERPAILQVNSSRDSWIGCIAVRLVKPRPKIIRIRHISTPLNRNMTTQLLYRRLLDMVVVTGGERTRRDLIERDGLEPGRVAAFPIGLDVAHFRPGPPARDLRRELGLPATHLLVGIISYLRTYKGHEYFIEAAGRIAAQRDDVTFVIVGEGPEEQSIRRRIEQSGAAWRIRLLGFRDDLLDVFRSLDVFAIPSVEGDTIPQVLMQALALGIPVVSTTIGSIPDVVIDGQTGYVVPPRDGLALADRIAHLLGDAGLRSRLGANGRALVEGSYSIDKMLDRMEAVYQSLAQSLTRSPAGGSTSGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZX5</accession>
    <name>A0A1W1HZX5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46310">
        <property type="protein sequence ID" value="SLM46310"/>
        <property type="gene ID" value="NSJP_0138"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0138"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021409">
        <property type="entry name" value="DUF3047"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11249">
        <property type="entry name" value="DUF3047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010739958" evidence="1">
        <location>
            <begin position="20"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="210" mass="22967" checksum="6F77BD46DA45A198" modified="2017-06-07" version="1">MRVLLALLFGGLVIAQGSAVGQGQALVLEDFQAKDADGFPSSWDHESQRSHSKGRDAYKIQTENGSSYLSAKDAGQRIKKKKIDWDPKAYPVLTWRWRLNKAVAGTEPLAAIYASLDTDLMFIPVFTKYVWSATKPEGTLTEGGMFSGSEIVVQSGTGEIGQWFEEKVNVYDDFKRIHQHEPAAKAWGISIIAGPGVEIDFGPMTASAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I013</accession>
    <name>A0A1W1I013_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46324">
        <property type="protein sequence ID" value="SLM46324"/>
        <property type="gene ID" value="NSJP_0152"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0152"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026337">
        <property type="entry name" value="Mod_HExxH"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04267">
        <property type="entry name" value="mod_HExxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="522" mass="60593" checksum="6B007CBAF256BD60" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0A0</accession>
    <name>A0A1W1I0A0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fn3_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0147"/>
    <dbReference type="EnsemblBacteria" id="SLM46319">
        <property type="protein sequence ID" value="SLM46319"/>
        <property type="gene ID" value="NSJP_0147"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0147"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012009137" description="fn3_3 domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="fn3_3" evidence="2">
        <location>
            <begin position="220"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="308" mass="33934" checksum="F80F17D22CD4450F" modified="2017-06-07" version="1">MTPKRSVLVVFACMGLFWSWSSAPAFSYNVVDVQRGGTIEGTVVLDGPVPEPKGFNLITFPDPAYCGRISNGQGWRLLHDFVVGENNGLKDAIVLLEGVEAGKPFEVSVPLIEARDCMFTPFVTIVRNGHAVEVINMDPVMHDIQGYETSIEAGARVLFNTPLVMNQQHRRGDLHAIHNHAPGKSLVGPVYLNKGRRTFYMQCGFHAYMESWAMAVNNPYYTLTDGNGKFTIGDVPPGTYQLVVWHPQTGPGSAKMITVQPNGTIVEQLSLPAPKGNRTPYKVMHNPRFGPESLGYSVEITPLVEHQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0C4</accession>
    <name>A0A1W1I0C4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46446">
        <property type="protein sequence ID" value="SLM46446"/>
        <property type="gene ID" value="NSJP_0274"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0274"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="58" mass="6748" checksum="5E891E3F722F2C11" modified="2017-06-07" version="1">MRFHTMDFTANLLGFLRLIFTTRGIHIAYARHDSLNGYPLRFLHGSRVRRHSGTDSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I188</accession>
    <name>A0A1W1I188_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_0596</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46768">
        <property type="protein sequence ID" value="SLM46768"/>
        <property type="gene ID" value="NSJP_0596"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0596"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="71"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="178"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="400" mass="44509" checksum="589668E312888FE9" modified="2017-06-07" version="1">MGLTKRKDSYYVEFPVLVDGKTLRLAPNLSVGKLKRWKVGCKNKEEARKQEAIIKTKLLQGMSTEVPTVPITVRDYCQRWLKSSKVNLAARTHSSYSQIVRLYIEPALGGQAVAALGWANVRAMLNVKQQAGCSADTTRIIRAVLSSMLTDAAEEGVIAVNPLLGQRRKRRAGQTIAPDVDPLTWQQKEAFETKLDELEESQSLSRSYTMLFRTYLKTGLRPSEGRALQPGDIDFVGRRVRVERSATLEGQIKSTKTGESRWVDLSDGILAELESYLTHLRAEDIARGKASDWLFPSLSGGLLDESHVVRAFHRVLDAAGLPRFRVYDLRHTFASLLLSSNVPLLYVSHQLGHTKPTITLKYYARWIPSGEVHRVNVLDAANTVITPATASREAATSLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1H3</accession>
    <name>A0A1W1I1H3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46845">
        <property type="protein sequence ID" value="SLM46845"/>
        <property type="gene ID" value="NSJP_0673"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0673"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012912925" evidence="1">
        <location>
            <begin position="25"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="122" mass="13166" checksum="9EB8476AE687FC1F" modified="2017-06-07" version="1">MKLSAAFLLCFAASGLSNVPPLLAEPIDPAEHSHAEQARDVHKAEHTVDHAWEVYHGAALGGTVASPTLQANIEQHLHDARTLVTKAHEAAERGDKSEVDRLVAQIRVHASQAIEGSKEQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1T2</accession>
    <name>A0A1W1I1T2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpsU</name>
        <name evidence="6" type="ORF">NSJP_0796</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0796"/>
    <dbReference type="EnsemblBacteria" id="SLM46968">
        <property type="protein sequence ID" value="SLM46968"/>
        <property type="gene ID" value="NSJP_0796"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0796"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00358">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="S21_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="64" mass="7856" checksum="5FF5972E3FA49C48" modified="2017-06-07" version="1">MEIKVFNNNVEKALKVAKKKLAGEGLFRELKRRRYYEKPSVRKKAKQREAQRRRQKWLSKRKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1T4</accession>
    <name>A0A1W1I1T4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Sulfurtransferase TusA</fullName>
            <ecNumber evidence="3">2.8.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0798"/>
    <dbReference type="EnsemblBacteria" id="SLM46970">
        <property type="protein sequence ID" value="SLM46970"/>
        <property type="gene ID" value="NSJP_0798"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0798"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="81" mass="9037" checksum="2B74EED42FFFF6E4" modified="2017-06-07" version="1">MITADVTLDTLGYFCPMPIIMTSKKIKELALGQVLEVVSDDEGIKKDMPAWCDTTGHQMLGLEEEQAQSGRIYKAFVKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1X4</accession>
    <name>A0A1W1I1X4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MlaA family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0825"/>
    <dbReference type="EnsemblBacteria" id="SLM46997">
        <property type="protein sequence ID" value="SLM46997"/>
        <property type="gene ID" value="NSJP_0825"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0825"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007428">
        <property type="entry name" value="MlaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30035">
        <property type="entry name" value="PTHR30035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04333">
        <property type="entry name" value="MlaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01805">
        <property type="entry name" value="VACJLIPOPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012529055" evidence="3">
        <location>
            <begin position="25"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="317" mass="34785" checksum="8C52D3830B5B7138" modified="2017-06-07" version="1">MNFVLIRRVSCVLGLVLIVTSGCAELEVAGTPRLTGDGGLLNAVGAMPPDHTLGSANGPAADGSRDIRAAAETSPPVSSREPAEEIFDPFAKSDEVTGEDYDPWEPVNTKIFEFNRQMDRYVLKPVAQGYDFIVPDLVQIGVGNIFYNFRFVPRFLNNVFQGKVKGASIEVGRFILNSTVGIGGFFDLAQDVNLVTPEEDLGQTLGFYGVKPGPYIVVPFLAPYTLRDLIGYVGDIFLNPINWLFAPIIEVKGVPSVISHPNRNTSTIVQLGARVGEIVNDRSRNLQKFQGVEEATFDLYTAVRNAYLQQRARQIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2B3</accession>
    <name>A0A1W1I2B3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0962"/>
    <dbReference type="EnsemblBacteria" id="SLM47134">
        <property type="protein sequence ID" value="SLM47134"/>
        <property type="gene ID" value="NSJP_0962"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0962"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="119" mass="13790" checksum="CB003A4425FB54BB" modified="2017-06-07" version="1">MRWFWRPGLLFTILFFFGAAYLLVALNYSYSDGNRAGYIQKLSTKGWICKTTEGELAMTTVPGVAPVLWEFSVWDENVAAQLTQLIGKRLVLHYKEYRYLPTTCFGDTPYFVDRVEVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2I7</accession>
    <name>A0A1W1I2I7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative pterin-4-alpha-carbinolamine dehydratase</fullName>
            <shortName evidence="4">PHS</shortName>
            <ecNumber evidence="4">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pterin carbinolamine dehydratase</fullName>
            <shortName evidence="4">PCD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_1058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1058"/>
    <dbReference type="EnsemblBacteria" id="SLM47230">
        <property type="protein sequence ID" value="SLM47230"/>
        <property type="gene ID" value="NSJP_1058"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1058"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTHR12599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="116" mass="12670" checksum="015538975C867B4B" modified="2017-06-07" version="1">MSLADNKCVPCRGGVPPVPNDRAQALLKELGRGWGINTQGHLERLYTFADFAQALTFVNKVGAVAEAEGHHPDLHLAWGKCTVEVWTHKINGLTESDFYLAAKADREFGLLKPSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2K3</accession>
    <name>A0A1W1I2K3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyphosphate:nucleotide phosphotransferase, PPK2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_1052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1052"/>
    <dbReference type="EnsemblBacteria" id="SLM47224">
        <property type="protein sequence ID" value="SLM47224"/>
        <property type="gene ID" value="NSJP_1052"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1052"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016898">
        <property type="entry name" value="Polyphosphate_phosphotransfera"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022300">
        <property type="entry name" value="PPK2-rel_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028756">
        <property type="entry name" value="PPK2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03709">
        <property type="entry name" value="PPK2_rel_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="4">
        <location>
            <begin position="31"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="272" mass="31511" checksum="94FB34E53AAF850F" modified="2017-06-07" version="1">MKLHRVKSGSRLDLGACDPDDTGPYKKNDEDKAAAKAETRQLIRKLSRLQERLYANKKCSLLIVLQGMDTSGKDGTIRSVMSGVNPQGCKVVSFKTPSSKELAHDFLWRVHQEVPAKGYIGIFNRSHYEDVLITRVHGEVSEREVKRRFTQIQEFENLLIDNGTTILKFFLHISKDEQKERLEARIRNPEKRWKWESGDIEERKFWNDYMKAFEDVMSATSTDHAPWYIVPANRKWYRNLAVADRVVRAMEDLKIGTPPSASDVDWDRLKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2P1</accession>
    <name>A0A1W1I2P1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47241">
        <property type="protein sequence ID" value="SLM47241"/>
        <property type="gene ID" value="NSJP_1069"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1069"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="48" mass="5094" checksum="59531B6529D0B30C" modified="2017-06-07" version="1">MVILSGAAVRRRGTLKQVGGEPLAWYQGIVLAGRKEVMRVGALSFPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2P7</accession>
    <name>A0A1W1I2P7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoheptose isomerase</fullName>
            <ecNumber evidence="9">5.3.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Sedoheptulose 7-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">gmhA</name>
        <name evidence="11" type="ORF">NSJP_0921</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27489"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:60203"/>
            <dbReference type="ChEBI" id="CHEBI:60204"/>
            <dbReference type="EC" id="5.3.1.28"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SIS family. GmhA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.28" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0921"/>
    <dbReference type="EnsemblBacteria" id="SLM47093">
        <property type="protein sequence ID" value="SLM47093"/>
        <property type="gene ID" value="NSJP_0921"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0921"/>
    <dbReference type="UniPathway" id="UPA00041">
        <property type="reaction ID" value="UER00436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008968">
        <property type="term" value="F:D-sedoheptulose 7-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001061">
        <property type="term" value="P:D-glycero-D-manno-heptose 7-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05006">
        <property type="entry name" value="SIS_GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00067">
        <property type="entry name" value="GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035461">
        <property type="entry name" value="GmhA/DiaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004515">
        <property type="entry name" value="Phosphoheptose_Isoase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="44"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="59"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="101"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM47093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="202" mass="21234" checksum="A56D88023A965A3F" modified="2017-06-07" version="1">MVARPLESRAMKDVVLNAFAESTAVKQQFVREQADRIVRVAELTAAALAKGHKVLLFGNGGSATDAAHIAAEFVGRYRRDRAPLPAIALATDIAAITCIANDYGYDELFARQVRAHGRAGDIAIAISTSGNSPNVLKGAEAAKACGLITVAWTGGSGGKLAGLVEFPFIVPSTVTARIQECHITMGHVICELIEDHLLGKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2S5</accession>
    <name>A0A1W1I2S5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47316">
        <property type="protein sequence ID" value="SLM47316"/>
        <property type="gene ID" value="NSJP_1144"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1144"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="170" mass="18011" checksum="7314D645A7542F0C" modified="2017-06-07" version="1">MAPRIEVAHSVISRRPMQSPRINWLEMAAGWALAVALQMVLLFLGFGLGAGAIDLRSAGEELRQQLASALMADRSAVSPTWSIPAGDQIGEAAFEQTGATDAALDRNMGPARVANVLPDLRAEKTSPIPSIGGQLLDHAGPVVFWLAIWGAITWLASIFTSAPRTPSSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2V5</accession>
    <name>A0A1W1I2V5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycogen operon protein GlgX homolog</fullName>
            <ecNumber evidence="4">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glgX</name>
        <name evidence="4" type="ORF">NSJP_1129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1129"/>
    <dbReference type="EnsemblBacteria" id="SLM47301">
        <property type="protein sequence ID" value="SLM47301"/>
        <property type="gene ID" value="NSJP_1129"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1129"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="142"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="723" mass="81976" checksum="80BC37BA3C95B79F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I324</accession>
    <name>A0A1W1I324_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="6">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">suhB</name>
        <name evidence="7" type="ORF">NSJP_1061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1061"/>
    <dbReference type="EnsemblBacteria" id="SLM47233">
        <property type="protein sequence ID" value="SLM47233"/>
        <property type="gene ID" value="NSJP_1061"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1061"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022337">
        <property type="entry name" value="Inositol_monophosphatase_SuhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01959">
        <property type="entry name" value="SBIMPHPHTASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="273" mass="29764" checksum="2CC9E60717D7E0BE" modified="2017-06-07" version="1">MLPTESEDISPDQLMTEAVEAAKQAGALLLSYAKTGFRIEHKNAIDLVTDADRAAERCILEHIRSRFPSHRILSEEQGPVVQIPSRYQWIVDPLDGTTNFAHGFPFYSVSIGVERDGTGLIGVVFDPTRNELFTAQAGAGARLNGTPLAVSRVDHLDRALLVTGFSYDIRETANNNLDHFARFALKAQGLRRTGSAALDLCYVAAGRFDGFWEVRLSPWDMAAGIVILSEAGGIVTNFAGGTHSIYGKELVASNRLIHPAMLGLLRQNTRPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I362</accession>
    <name>A0A1W1I362_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47446">
        <property type="protein sequence ID" value="SLM47446"/>
        <property type="gene ID" value="NSJP_1274"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1274"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="92" mass="10261" checksum="36CEBE8D0A9FA19C" modified="2017-06-07" version="1">MKISPVWNRNAPKKKKTRSTSKPKIRWELLGLSDPAVTEPTAIETIRRSVSSLASQGFGDETLLRSAEQEMKGRARTRRSGGKGVTRRPRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3B0</accession>
    <name>A0A1W1I3B0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit K</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit K</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">nuoK</name>
        <name evidence="6" type="ORF">NSJP_1302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1302"/>
    <dbReference type="EnsemblBacteria" id="SLM47474">
        <property type="protein sequence ID" value="SLM47474"/>
        <property type="gene ID" value="NSJP_1302"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1302"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="PTHR11434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="100" mass="10733" checksum="DC90C5551D6565AF" modified="2017-06-07" version="1">MIPLSAYVTVSAILFITGLLGVLIRRNFIIVLMAVEIMLNAANINLVAFSHYLESMAGQLVALFVIAIAAGEAAVGLAIIIVVFRGKISTNVDEMSLLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3C2</accession>
    <name>A0A1W1I3C2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Filamentous hemagglutinin family N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1289"/>
    <dbReference type="EnsemblBacteria" id="SLM47461">
        <property type="protein sequence ID" value="SLM47461"/>
        <property type="gene ID" value="NSJP_1289"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1289"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043709">
        <property type="entry name" value="DUF5649"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008638">
        <property type="entry name" value="Filamn_hemagglutn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18886">
        <property type="entry name" value="DUF5649"/>
        <property type="match status" value="41"/>
    </dbReference>
    <dbReference type="SMART" id="SM00912">
        <property type="entry name" value="Haemagg_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012438743" evidence="1">
        <location>
            <begin position="50"/>
            <end position="4151"/>
        </location>
    </feature>
    <feature type="domain" description="Haemagg_act" evidence="2">
        <location>
            <begin position="47"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="4151" mass="400191" checksum="5F607EE278425678" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3G8</accession>
    <name>A0A1W1I3G8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1339"/>
    <dbReference type="EnsemblBacteria" id="SLM47511">
        <property type="protein sequence ID" value="SLM47511"/>
        <property type="gene ID" value="NSJP_1339"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1339"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007433">
        <property type="entry name" value="DUF481"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04338">
        <property type="entry name" value="DUF481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012890387" evidence="1">
        <location>
            <begin position="27"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="372" mass="41602" checksum="BA3992101DDE3160" modified="2017-06-07" version="1">MRRPSILNACTVVLVIWLTFPFVAHAADTEAAAGPPAPVPIDIVTLKDGSVLYGEVIEMTEGTLHLKTVDSADKAFKVKWSEVSKLTVTHPLPFHLKEGTILVGTTQADKDGFLLLKVESLADPLTIPVGSVASINPLVQPPVIFVGAVTAGISTANGNTNFQNASFLLDLTGRSEKLRLLLNGRYVYNENDGQLAARNARGTIKLDFFFTKRFYAFTSAYFEQDTFQDLNLRTALATGPGYQFIDLGDFSGPYFKDMSLSGEFGVSYFNEDFKNLQDQSSVRGRGSLRFNWPMLDERVVLYHFDEFFPSFQNSKDYYLTMDQGIRLKLIEGFVANLQFTYRYNNTPPPGVQSTDTLYLITFGYNFDTTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3I5</accession>
    <name>A0A1W1I3I5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1231"/>
    <dbReference type="EnsemblBacteria" id="SLM47403">
        <property type="protein sequence ID" value="SLM47403"/>
        <property type="gene ID" value="NSJP_1231"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1231"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_11" evidence="2">
        <location>
            <begin position="1014"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_12" evidence="3">
        <location>
            <begin position="1153"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1497"/>
            <end position="1531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1531" mass="170823" checksum="3E6C754D7AD313D2" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3X4</accession>
    <name>A0A1W1I3X4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47675">
        <property type="protein sequence ID" value="SLM47675"/>
        <property type="gene ID" value="NSJP_1503"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1503"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="30" mass="3374" checksum="1B3055EE88ED0F41" modified="2017-06-07" version="1">MSVKVSVSISSPRSLLTQWTLTLPAIDMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I480</accession>
    <name>A0A1W1I480_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="14">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 20" type="primary">secA</name>
        <name evidence="20" type="ORF">NSJP_1638</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="14">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="14"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1638"/>
    <dbReference type="EnsemblBacteria" id="SLM47810">
        <property type="protein sequence ID" value="SLM47810"/>
        <property type="gene ID" value="NSJP_1638"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1638"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="12 14 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14 15" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="19">
        <location>
            <begin position="3"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="89"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="438"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="845"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="105"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SLM47810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="906" mass="102456" checksum="4352443D601C7475" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4D3</accession>
    <name>A0A1W1I4D3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-aminoethylphosphonate aminotransferase</fullName>
            <ecNumber evidence="5">2.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">phnW</name>
        <name evidence="5" type="ORF">NSJP_1715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1715"/>
    <dbReference type="EnsemblBacteria" id="SLM47887">
        <property type="protein sequence ID" value="SLM47887"/>
        <property type="gene ID" value="NSJP_1715"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1715"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047304">
        <property type="term" value="F:2-aminoethylphosphonate-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019700">
        <property type="term" value="P:organic phosphonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01376">
        <property type="entry name" value="PhnW_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012703">
        <property type="entry name" value="NH2EtPonate_pyrv_transaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="50"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="360" mass="39795" checksum="BE634A371CC8BCDA" modified="2017-06-07" version="1">MMLLNPGPVNVSDRVRQALLRQDICHRESEFSELLAGIQSKLLKAFVPGAEADYVAVLITGSGTSAVEAAVLSSLPHGKRMLVLNNGVYGERMSQMVGIHRLGASELKFEWTVTPDPERLRLALRQHPEVHAVAMVHHETTTGLINPVKAIAEVVDSQNRVFILDAVSALGGEPLDIAGNHIYMVGGTAGKCIQGFPGVSFVLLRRGFLERMRAYPKRSWYLHLTHYVNDQGQGIIPFTPAVQVYYAFDEALNELLEEGVAKRIQRYKKMATLIRERMAKLGMKAVLTPDRQSNTITAYYLPEGLSYQTLHDQLKAQGYVIYAGQGNLENKIFRVANMGALTEAQFTAFLDAVERVCASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4G0</accession>
    <name>A0A1W1I4G0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1720"/>
    <dbReference type="EnsemblBacteria" id="SLM47892">
        <property type="protein sequence ID" value="SLM47892"/>
        <property type="gene ID" value="NSJP_1720"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1720"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="57"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="359" mass="40109" checksum="579EA72930ADE56F" modified="2017-06-07" version="1">MRWLIRFIVGMLLLALTGAAYQAVDLALDAQLYPPPGRLVDVGGHELHLRCMGEGIPTVVLESANMGWSLYWTTIQFDLARLTRVCSYDRAGLGWSERGPSPRTGRHIANELHTLLARARVSGPFILVGHSLGGFVTRLYYETHREDVAAMVLVDAHHERQFDEEEFREFIAAVRTAFPIMGAATTLGITRLMLTLDVLPPLFARQEKGAPPDIRPMLRAGWAKTRYFATMADEEASLEATASQVKRAGLLGDLPLIIVTAAGPTWWPDMPQDVDLSRFRHMWLNLQADLLKLSTNSRQVFADKSTHFVNFDQPEIIVEQVRQLIEFSRPASGPSAMRQPTMLKPESVAIPFMKPAVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4H6</accession>
    <name>A0A1W1I4H6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative nickel-responsive regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NSJP_1669</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transcriptional regulator.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="7">Binds 1 nickel ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the transcriptional regulatory CopG/NikR family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1669"/>
    <dbReference type="EnsemblBacteria" id="SLM47841">
        <property type="protein sequence ID" value="SLM47841"/>
        <property type="gene ID" value="NSJP_1669"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1669"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010045">
        <property type="term" value="P:response to nickel cation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00476">
        <property type="entry name" value="NikR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022988">
        <property type="entry name" value="Ni_resp_reg_NikR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014864">
        <property type="entry name" value="TF_NikR_Ni-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08753">
        <property type="entry name" value="NikR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0533">Nickel</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RHH_1" evidence="8">
        <location>
            <begin position="6"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="NikR_C" evidence="9">
        <location>
            <begin position="57"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="140" mass="15774" checksum="7F3A7885BDF240B5" modified="2017-06-07" version="1">MKKLVRFGVSLDHHLLDGFDRHIERRKYTNRSEALRDLIRDQLVSQEWTGEADKESVATITFVYDHHVRDLSGKLTHIQHDFQGHILAGMHVHLDHNHCLEVLVVKGKGSQIRAVADALVSVKGVKHGKLTMTTTGKGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4L4</accession>
    <name>A0A1W1I4L4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="1">PPIase</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ppiA</name>
        <name evidence="3" type="ORF">NSJP_1774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47946">
        <property type="protein sequence ID" value="SLM47946"/>
        <property type="gene ID" value="NSJP_1774"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1774"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011826118" description="Peptidyl-prolyl cis-trans isomerase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="47"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="195" mass="21518" checksum="4C476F67CF7C7AE0" modified="2017-06-07" version="1">MQMWKRLMVGACLGAGLIAGAWNAEGADKMSGKAETSPRAIIKTKFGDMEIAFFPDKAPKHVENFLKLAKSGFYNGTIFHRVIPGFMIQGGDPNTKDVNKPETYGQGGPNERLKAEFNDIPHRRGIVSMARTNDPNSAGSQFFIVVKDSNFLDNQYTVFGEVVKGLEVADQIANLPRNPRDLPTERVEMTITLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4M3</accession>
    <name>A0A1W1I4M3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1657"/>
    <dbReference type="EnsemblBacteria" id="SLM47829">
        <property type="protein sequence ID" value="SLM47829"/>
        <property type="gene ID" value="NSJP_1657"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1657"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013071471" evidence="2">
        <location>
            <begin position="25"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="234"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="348" mass="39050" checksum="45D6FFF799F1C1C1" modified="2017-06-07" version="1">MVALLFELLLASFLLLSFPSIDLAAPTDSGKRALERAAGLLKAGDADGALAAVNKTLEANQSAEAYYLLGQIYFKGKKKPAEAVEALTHAIKLKPAYPEALNDLAEVYLAQGKSTEAEQTLKRAIEIDPKHEDSYLDLARLYEGRRDIPAAMAAYKQLLAVDPTQPDSLFGLAMLYERQGENKAARDTLARLTKAHPKHADAWYQAGRLAERSNDLLEAAYAYRQAIAAKPDLVDAHYNLGFIFRSQGKPAEAEREFLEVIRYRPEYAEAHMNLGVIYTSMNRLEEAEQEYQRAVELKPEYTEAHYNLGVFYELHRKDLPKALAQYHKYRNLGGRDDRVERIVGMSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4N6</accession>
    <name>A0A1W1I4N6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aubR</name>
        <name evidence="3" type="ORF">NSJP_1611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1611"/>
    <dbReference type="EnsemblBacteria" id="SLM47783">
        <property type="protein sequence ID" value="SLM47783"/>
        <property type="gene ID" value="NSJP_1611"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1611"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005143">
        <property type="entry name" value="TF_LuxR_autoind-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036693">
        <property type="entry name" value="TF_LuxR_autoind-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03472">
        <property type="entry name" value="Autoind_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75516">
        <property type="entry name" value="SSF75516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="195"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="271" mass="30498" checksum="6F5FE84F4B6B2150" modified="2017-06-07" version="1">MAEASKYPFPGQVFTALSRLECEHSLEVLHYAAQAETSEDIKGVLELIQTHFPFSRLLGGLARLGSGGRFEGFANVVNVSYPDEWLRLYWQNSFFEVDPVFQKALKAPGTQLWKDTYRSATSKKEKEFIRTAEEFGLQSGITTGSADQACSIATFCSFAGESDLEAERYLPLMEYLGYHLHLALMRTEPRHTYALDRCVKKLSVRELTILNWMKNGKTNWEIAQILGVTERTIRFHVESIFSKLDVTSRSQAVATAIEHGLPNLHGLPSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I507</accession>
    <name>A0A1W1I507_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TYR_PHOSPHATASE_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1797"/>
    <dbReference type="EnsemblBacteria" id="SLM47969">
        <property type="protein sequence ID" value="SLM47969"/>
        <property type="gene ID" value="NSJP_1797"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1797"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="1">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="148" mass="15808" checksum="A1B8631E0C6681FD" modified="2017-06-07" version="1">MAMYQITDKLAVGNVSDAENPPASIGALLMVAVELSIMPPAGVAYDKIPLKEYGEAGISSLDQAVAWIEAHLPENRVLVCCRAGMGRSVSVVLAYLCCAEDMAYPDALSLLLKRRPGAVPLPNLRCAIEALQQLRESRRVSNASGLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I523</accession>
    <name>A0A1W1I523_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48118">
        <property type="protein sequence ID" value="SLM48118"/>
        <property type="gene ID" value="NSJP_1946"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1946"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="56" mass="6213" checksum="59FF471DF3C93FC0" modified="2017-06-07" version="1">MVWGVPEAAHPPVERAAREERQEAVAVDNACLHTTVSGWRLSQWQSGSVMTILQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I532</accession>
    <name>A0A1W1I532_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1955</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48127">
        <property type="protein sequence ID" value="SLM48127"/>
        <property type="gene ID" value="NSJP_1955"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1955"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="67"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="140"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="437"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="40"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="557" mass="62408" checksum="56A834761031DB7B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I567</accession>
    <name>A0A1W1I567_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Nitrate oxidoreductase, gamma subunit</fullName>
            <ecNumber evidence="9">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_1857</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.7.99.4" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1857"/>
    <dbReference type="EnsemblBacteria" id="SLM48029">
        <property type="protein sequence ID" value="SLM48029"/>
        <property type="gene ID" value="NSJP_1857"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1857"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019020">
        <property type="entry name" value="Cyt-c552/DMSO_Rdtase_haem-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09459">
        <property type="entry name" value="EB_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00887">
        <property type="entry name" value="EB_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012596657" evidence="7">
        <location>
            <begin position="33"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="EB_dh" evidence="8">
        <location>
            <begin position="54"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="277" mass="30354" checksum="37980BEEAC39E24A" modified="2017-06-07" version="1">MKSAKRKTQWHKGRAMLLASAMVLCGATASLAQESVAVRAPLVKGTLPAEDPESAVWNSAPLSQFPMSPQVHWPNRILEATVKDVKVRALHDGTQVAFLLEYADPTQDPDDAAALEFMVGEKKAHFAHGQPMAQVEGGPVNIWYWKNKDNKAVDMSALGFGTLKSQTHQDVKAKGVYANGTWKVVFSRPLATEHPNEDTQVKPGEFINVAFAVWDGQKDGSGEVREKGSQKAVSSWWYFRAEPPADYSGYLYAVVAIAIAVGFQFVLIRKLKKGQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I579</accession>
    <name>A0A1W1I579_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zot domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48039">
        <property type="protein sequence ID" value="SLM48039"/>
        <property type="gene ID" value="NSJP_1867"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1867"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008900">
        <property type="entry name" value="Zot_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05707">
        <property type="entry name" value="Zot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zot" evidence="2">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="384" mass="41975" checksum="D85EB1F88C3C846E" modified="2017-06-07" version="1">MIELLEGVPGAGKSYHAVAEYLLPWVRKGRRIYVYVDGFYLDRLAKFEGRPLEELQQQITVWSSGAEVLDQLTKVDPGSAVFIDECQTVFRAQQKLHGEILRWLETHRHYGIDVLLICQDYRQVTSGVTRVVEMTTKFRRLDRFGFKNRYQAFVRGNPEELEIIRGFTGTYEPTVYAYYGSYATSTKEVRHVRSILRSPSIILGALGLCVALSWFLFGGGTFGGGTTLPPPPVRVPVAAITRTPQEPEPSGSRPVVHPIRIQGGMSDPRQGGADWLWVTDDGRLLTVDEIAAESGGTVQAVTSRGVKVLKGSGVLWGGTVSPQSGSAGSMPEPVLAPSRLPTRTDPLVAPTSARVDQSGVASPADLITSDRSPAILDQGTEPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5M3</accession>
    <name>A0A1W1I5M3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48312">
        <property type="protein sequence ID" value="SLM48312"/>
        <property type="gene ID" value="NSJP_2140"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2140"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010691494" evidence="2">
        <location>
            <begin position="22"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="180" mass="19396" checksum="DB9C6E00ABB6ECE8" modified="2017-06-07" version="1">MRGATWLFMGVSLLGSGPVAAQLLPPVSDDVKIQVTQQEIDEDAAGRNPANHAEAMARQFHVEKDVVEQLRQAKVGWGEIGIRLAFAQEVAKQDAKQFPSVEAALSKVNDRRSNRANWGAMANEFGIDLVQVVVGAQQGRQQMRADAKKEATAGVVKPGGQQPDLTDKRDGTPKRGAATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5M6</accession>
    <name>A0A1W1I5M6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sigma-54 dependent DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NSJP_2118</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2118"/>
    <dbReference type="EnsemblBacteria" id="SLM48290">
        <property type="protein sequence ID" value="SLM48290"/>
        <property type="gene ID" value="NSJP_2118"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2118"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="8">
        <location>
            <begin position="138"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM48290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="456" mass="49920" checksum="E0A48A8B7EC63E5E" modified="2017-06-07" version="1">MPPLLLVISSDPSTKTTLEKSVSDLPLILQFAPTPEEGLRVLGERTDFDCVIFDEHRQSRPLNSILPQFRSLAPSIPVVVVGVEDSARAAVDALRSGAADYLVNPLTTSDVRTTLLRMQIAAGADQASAAGSSGFDRIISVSSQMRLVKHLAAEVAATDATVLITGESGTGKELFAHAIHAASPRAKGPFVALNCAGIPEHLMESELFGYQRGAFTDAKQPKLGRFQAAEGGTVFLDEIGEVSPMAQAKLLRVLEDHVISPLGDTRDIPVDIRVVAATNEDLPAHIKAGKFRLDLYYRLNVYQLRIPPLRERPDDIEPLVRHFLDTIRRDRGRRVPDFSPAAIEWLRRHDWPGNVRELHNVVEGLTITCKSPTILPEHLPASFSNSGAPTPPAKADLPDGHARPSLLAFGLSLQDMEKKMLMEALHEAGGNISEASRLLKLTRNTLRYRMAKYRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5W4</accession>
    <name>A0A1W1I5W4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2224"/>
    <dbReference type="EnsemblBacteria" id="SLM48396">
        <property type="protein sequence ID" value="SLM48396"/>
        <property type="gene ID" value="NSJP_2224"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2224"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044036">
        <property type="entry name" value="DUF5752"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19027">
        <property type="entry name" value="DUF5752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="230" mass="26949" checksum="8351E674B980C73F" modified="2017-06-07" version="1">MAPTSRRPFLFMECSEIREILGEAAEDERRLVELLESVPLDSIYFHTHSYFLRHSYVERVYPNDFAQWVAMEVRDHVLAERLAVVDPFEFRGLEAFRGELISIIDDHLSKMPIVPRVIFGQPFYFNTSRILQVPTSREVRTLQEFRTALSDVEVSAIYFHVFEARHRLKEEESDFSTWVEQGLGFPELAERLRAINPYLGSLERLRSALLTACDDFLKSQDSSEERRELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5W6</accession>
    <name>A0A1W1I5W6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2246"/>
    <dbReference type="EnsemblBacteria" id="SLM48418">
        <property type="protein sequence ID" value="SLM48418"/>
        <property type="gene ID" value="NSJP_2246"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2246"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005021">
        <property type="entry name" value="Terminase_largesu_Lambdalike"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03354">
        <property type="entry name" value="Terminase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="482" mass="52683" checksum="4EC35834E520B043" modified="2017-06-07" version="1">MIGAPSRIAACAGQVSPMQFFSLLSWLDGRPLLDVMETYRQQILTEALFSVRPDGRPQFKRILTGRAKKNGKTADAVMAALYKLLVWVPAGNAGNQCFFVASDLGQANDDLDLAKKIIRCNPILESELNVMRNIVERRDGKGFLQILPAGDAPGLHGKTYLFLVVDELHTQSDYRLLEALELDRTRPDAVQWFASYAAISTQSGIPINDMLRQYHKGTDPRLFVSWFSGSIEEANPSLNGPLGPTLPDIEDAQRSLPSWIFRRLYLNLPGQPDGAAFDAGGIDAAVIPGRIVLPPQLGIKYMAFADLSGGGADDATLAIAHAQDGRAILDLLIDQGPRTNGTFSPENAVTLFSSVLKQYGCTVVIGDRYAAQWPIQAFAKCGIQYRPAQQTRSQLYANLEPLLNSGRIELLDQSKLIGQLIGLVRKGEKIDHSIGQHDDWANAATGVLVSAATLPKTVSKESIEGWIESCSRLSKSRWRPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I639</accession>
    <name>A0A1W1I639_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48477">
        <property type="protein sequence ID" value="SLM48477"/>
        <property type="gene ID" value="NSJP_2305"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2305"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="134" mass="15053" checksum="7659227785A36B5D" modified="2017-06-07" version="1">MRKPNVFVAILLVMSLSGCSVLMVASRDTKRGDLTVIQLGAQRSTVINELGQPDNFFTREDGGYDDRYKLDPDAHSGIAKFFTGFFYFAADFFTLCLTELIFTPVEIAFKDKLVIFHLTYGADQKLATIEKIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I648</accession>
    <name>A0A1W1I648_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2131"/>
    <dbReference type="EnsemblBacteria" id="SLM48303">
        <property type="protein sequence ID" value="SLM48303"/>
        <property type="gene ID" value="NSJP_2131"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2131"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="144" mass="15129" checksum="7569797607B36948" modified="2017-06-07" version="1">MDIERRSFTASGGFTLTELMTVLAIVSLLIAIGVTSYSRFIAKAKSVEAEIALSEIHRLEQIHYASTGTYTADVDELGFKPFQPLKYYSLSVQVAGESGNGAFRALAVPLSGSGGQTFSVVQYAPDKISSGGGAPPSGQSSNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6A5</accession>
    <name>A0A1W1I6A5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized endonuclease (Modular protein)</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48409">
        <property type="protein sequence ID" value="SLM48409"/>
        <property type="gene ID" value="NSJP_2237"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2237"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002071">
        <property type="entry name" value="Thermonucl_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01123">
        <property type="entry name" value="TNASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013275110" evidence="1">
        <location>
            <begin position="24"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="2">
        <location>
            <begin position="27"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="228" mass="25905" checksum="46550CCBBC6AC37E" modified="2017-06-07" version="1">MFLNFLKSLFLACPFLLPTLAISSVTANNSAKVVSIIDGDTIEVLQDRRIVRIRLIGIDCPERGQAYGKKAKQAAATLIYGKDVTLDRYGVDRYGRTLADVMLTDGTNINHKLVKEGWCWWYRKYSPANSELQRLEQEARDAKKGLWIDPSPTPPWIYRKTRHGQRLNQSDLVPLRHNSISHQILAASINSQPSHEPFKRPMCEAFRSACLSRQSNPWTYPLSFGMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6A8</accession>
    <name>A0A1W1I6A8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">secY</name>
        <name evidence="13" type="ORF">NSJP_2358</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2358"/>
    <dbReference type="EnsemblBacteria" id="SLM48530">
        <property type="protein sequence ID" value="SLM48530"/>
        <property type="gene ID" value="NSJP_2358"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2358"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM48530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="439" mass="47749" checksum="86A73E03A5B6C430" modified="2017-06-07" version="1">MFERLLTSFQNIFKIPELRTRILFTLGMLVVYRVGAHIPTPGINGEALQDFLQKQGGALLGFLDIFSGGSLSRLTIFALGIMPYISASIILQLLTVVIPHLTKLAKEGERGRKKIIQYTRFGTIGIALIQGFGIAVGLEQMNGGAFVLDKGWGFRLMTVITLTAGTAFLMWLGEQITERGIGNGISLIIFAGIVARLPAAVAQTFDLYKVGQLSFLLLAALAVLMVAVVAAIVFLESGRRKVPVQYAKRVVGRRVYGGQSTHIPLKINTAGVIPPIFASSIIAFPATIAGFFETPWVKAIGAQLAPGSLLYTLMYVGLILFFCFFYTAVVLNPVDMADNMKKYGGFIPGIRPGQRTSDYIYKVLTHITFAGAIYLAIVCVIPEFLIYKLNVPFYFGGTSLLIVIGVGLDTAQQIESHMLMRNYEGFLGKGMGPLRGRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6C3</accession>
    <name>A0A1W1I6C3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Urea ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_2384</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2384"/>
    <dbReference type="EnsemblBacteria" id="SLM48556">
        <property type="protein sequence ID" value="SLM48556"/>
        <property type="gene ID" value="NSJP_2384"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2384"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017779">
        <property type="entry name" value="ABC_UrtB_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03409">
        <property type="entry name" value="urea_trans_UrtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012438739" evidence="7">
        <location>
            <begin position="27"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="518" mass="55526" checksum="1038479936DB78BD" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6G3</accession>
    <name>A0A1W1I6G3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48618">
        <property type="protein sequence ID" value="SLM48618"/>
        <property type="gene ID" value="NSJP_2446"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2446"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="72" mass="8076" checksum="4B2C77C253C3B779" modified="2017-06-07" version="1">MLKGFLNYGLVAAVLVWAAVVGLMAYRLEDSPWRWAFIALVFAGILTIVAIFRIRRYIDGLSKAEQDRGSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6L7</accession>
    <name>A0A1W1I6L7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">rpsQ</name>
        <name evidence="4" type="ORF">NSJP_2347</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2347"/>
    <dbReference type="EnsemblBacteria" id="SLM48519">
        <property type="protein sequence ID" value="SLM48519"/>
        <property type="gene ID" value="NSJP_2347"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2347"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="88" mass="10245" checksum="74B141B92A26679B" modified="2017-06-07" version="1">MAETGVKRREWIGRVVSNKMNKTVVVAVERSVVHPIYRKVLRRITKLKAHDEQNACGIGDRVRMIETRPISKEKHWRVVEVLEKGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I720</accession>
    <name>A0A1W1I720_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FHA domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2639"/>
    <dbReference type="EnsemblBacteria" id="SLM48806">
        <property type="protein sequence ID" value="SLM48806"/>
        <property type="gene ID" value="NSJP_2639"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2639"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="30"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="234" mass="25039" checksum="6A8B32EAF7B4ADFF" modified="2017-06-07" version="1">MAHTTDAPAKLLVKLHGQGSRTIEIMHDVYTIGRKTGNDLSIDDHTVSGHHARIVKVQAVYFLEDLNSTNGSSVNGMRVDRHQLRDSDVITIGQHRIIFQEPAAPAAAPPSPSSFVDETMAISGGESGIPAASLSAKVVVTDGSTERPEYLLNKPVSSIGSQQGAAIRLTGWFAPKFAAQIIQRGGAYFVSLAQGGKTLLVNGRDVTGQQQLRNGDHIQVAGVSLTFYWLGSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I725</accession>
    <name>A0A1W1I725_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Ion transport 2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2497"/>
    <dbReference type="EnsemblBacteria" id="SLM48669">
        <property type="protein sequence ID" value="SLM48669"/>
        <property type="gene ID" value="NSJP_2497"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2497"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="274" mass="30490" checksum="74F38853F2D0C2F8" modified="2017-06-07" version="1">MSQVTFTDPAAQEFYRQGESELEAAQSADAVLRKAEAFGRKDARAEVMQSAFYFLAAAHFLENRDPAKAAQAYHQAGGQLHRLEQFSQAGRAYSNAGRLSERAAQATGGGPASHDLQHFAVRSYSRANHCFAEVGELEWSEAEYLNERNARVAWAKMQGKHPWAQLAWKATSNYGTSFSRWGLWVAGTLGLFGLLYEVFYQISWLQPMDNMITAPWIPFWSGFYYSVNVTAALGLVDYQPSNVISQGVVIVNVLIGYILLGIGIGIIGRMIKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I759</accession>
    <name>A0A1W1I759_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OsmC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48709">
        <property type="protein sequence ID" value="SLM48709"/>
        <property type="gene ID" value="NSJP_2542"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2542"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="199" mass="21585" checksum="4E6D1CD847DB4B86" modified="2017-06-07" version="1">MNKQVSKACNGLDLEEMGQTVRALKNDPTLAQFQFRARNRWIDGGENRSTIKDFYGVGAEDTSRSDAFIFTNGEPPVLLGRNEGANPVEFLLHALAGCVTTTTVLHAAARGIKLHKLSTELTGNIDLQGLLALDDSVPVGYESIRIKMDIEADCSDEDLAELIAFAQLHSPVCNTVCRPVPVTIERVVAHRATSEAHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I768</accession>
    <name>A0A1W1I768_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48888">
        <property type="protein sequence ID" value="SLM48888"/>
        <property type="gene ID" value="NSJP_2721"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2721"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012596666" evidence="2">
        <location>
            <begin position="29"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="521" mass="57410" checksum="6C17420DBF78F84C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I794</accession>
    <name>A0A1W1I794_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tldD</name>
        <name evidence="6" type="ORF">NSJP_2624</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2624"/>
    <dbReference type="EnsemblBacteria" id="SLM48791">
        <property type="protein sequence ID" value="SLM48791"/>
        <property type="gene ID" value="NSJP_2624"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2624"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025502">
        <property type="entry name" value="TldD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004919">
        <property type="entry name" value="TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="3">
        <location>
            <begin position="32"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="5">
        <location>
            <begin position="129"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="4">
        <location>
            <begin position="240"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="477" mass="50907" checksum="992006DCD8A34636" modified="2017-06-07" version="1">MAQLIPLDSFGLTEREVYAALARVKVRAVDYADLYFESSVTESVSMEESLVKRATKSISQGVGVRATAGEKTGFAYSDELRKQDLELAADTARYIAMSPAGTDAPPVPVHARPRHDLYPVPQTALEVATGDRVVLLNQIDAEARKYDPRIKNVMASFNTEFKIVMVATSEGTIIGDVQPLSRLQVTCIAEENGNRQVGSFGGGGRIGFEFYREGDRHLAYAREAARTAILNLSAVDAPAGVMPVVLGGGWPGILLHEAIGHGLEADFNRKKTSAFSSLLGKRVASDVCTIVDDGTLPGRRGSLNMDDEGTPTGRTVLIERGILRGYITDKLNARLMGIPVTGNGRRESYQSVVLPRMTNTFMLAGQSEPEDIIKSVKKGLYAVSFGGGQVDITNGKFVFSASEAYLIENGKVTKPVKGATLIGSGPDILTKVSMAGHDLKLDEGIGTCGKEGQSVPVGVGLPTIKIDEITVGGTQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I798</accession>
    <name>A0A1W1I798_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48918">
        <property type="protein sequence ID" value="SLM48918"/>
        <property type="gene ID" value="NSJP_2751"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2751"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="221" mass="25143" checksum="7E8BF16EA2FFC081" modified="2017-06-07" version="1">MAASIGLLMIAPCSLYAEIPLDHMAGSVDAMVPHQRHLGPHMRWTSLRPVESGDERRADQIVQVLRSAIEKYRDYRVAESDGFVLLHPERTAKHYHFANRDHRQRARSAFDAAEPTALLYKKNGEGYELEGAMYTAPKDMDEDQLNRRIPLSIAQWHAHINICLAPDGSRNRMSRRSFGFKGTIVLESECREAGGQFVSQAGGWMIHVYPFESTRGRIWTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7H2</accession>
    <name>A0A1W1I7H2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inorganic diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppa</name>
        <name evidence="6" type="ORF">NSJP_2777</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2777"/>
    <dbReference type="EnsemblBacteria" id="SLM48944">
        <property type="protein sequence ID" value="SLM48944"/>
        <property type="gene ID" value="NSJP_2777"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2777"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="227" mass="25252" checksum="9841D219B34D3D74" modified="2017-06-07" version="1">MKRVGGDPIQRLMSLMFKAHPWHGVSIGERAPEVVTAYIEIVPTDTVKYEVDKDSGFLKVDRPQRFSNFCPVYYGLVPQTYCSDKVAGLFSKRARRKGMVGDRDPLDICVLTEKTIPHSDILLTAIPIGGFSLADGGEADDKIIAVMKEDAAYGSFKDIGDVPVALIDRLQHYFLTYKQAPGSVQHKVEITSVYDRDEALKVIRASHADYRAKFPELESLWPTGMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7N2</accession>
    <name>A0A1W1I7N2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable phosphoketolase</fullName>
            <ecNumber evidence="5">4.1.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_2865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the XFP family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.-" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2865"/>
    <dbReference type="EnsemblBacteria" id="SLM49032">
        <property type="protein sequence ID" value="SLM49032"/>
        <property type="gene ID" value="NSJP_2865"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2865"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PTHR31273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="XFP_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="XFP_C" evidence="6">
        <location>
            <begin position="583"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="803" mass="91313" checksum="DDAE6540DD232DCF" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Q6</accession>
    <name>A0A1W1I7Q6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2857"/>
    <dbReference type="EnsemblBacteria" id="SLM49024">
        <property type="protein sequence ID" value="SLM49024"/>
        <property type="gene ID" value="NSJP_2857"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2857"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="PTHR10412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="944" mass="107944" checksum="CD3408C7654E92FD" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7U3</accession>
    <name>A0A1W1I7U3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate transport protein (ABC superfamily, peri_bind)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sbp</name>
        <name evidence="7" type="ORF">NSJP_2824</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic sulfate-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2824"/>
    <dbReference type="EnsemblBacteria" id="SLM48991">
        <property type="protein sequence ID" value="SLM48991"/>
        <property type="gene ID" value="NSJP_2824"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2824"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901681">
        <property type="term" value="F:sulfur compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902358">
        <property type="term" value="P:sulfate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01005">
        <property type="entry name" value="PBP2_CysP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034408">
        <property type="entry name" value="Sulphate/thiosulphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005669">
        <property type="entry name" value="Thiosulph/SO4-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30368">
        <property type="entry name" value="PTHR30368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00971">
        <property type="entry name" value="3a0106s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00757">
        <property type="entry name" value="PROK_SULFATE_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012415908" evidence="6">
        <location>
            <begin position="27"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="344" mass="37917" checksum="3B924819FC5ED263" modified="2017-06-07" version="1">MAFTSLFLLVLLSLSGAVGLSSIAHAGNQTVTLLNVSYDPTRELYQEFNAAFAKHWLAKTGQPVSIKQSHGGSSKQARAVIDGLEADVVTLALAYDIDAIAEKASLLPANWQGRLPQNSAPYVSTIAFLVRKGNPKNIKDWSDLVKPGVSIITPNPKTSGVARWNYLAAWGYALKQSGGDETKAKEFIAKLYKNVPVLDSGARGATTTFVERGIGDVLINWENEILLGGGELGKDRFDIVVPPQSILAEPTVSVVDKIVDKRGTRQIAQAYLEYLYSEEGQEIAARHYYRPRLQSVAAKQTKFPKVELFTLQEFFGDWKHANKTHFSDGGTFDQIYLQITKERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Y6</accession>
    <name>A0A1W1I7Y6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyrophosphate--fructose 6-phosphate 1-phosphotransferase</fullName>
            <ecNumber evidence="10">2.7.1.90</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">6-phosphofructokinase, pyrophosphate dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">PPi-dependent phosphofructokinase</fullName>
            <shortName evidence="10">PPi-PFK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pyrophosphate-dependent 6-phosphofructose-1-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pfkA</name>
        <name evidence="10" type="synonym">pfp</name>
        <name evidence="12" type="ORF">NSJP_2864</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Non-allosteric.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Short' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.90" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2864"/>
    <dbReference type="EnsemblBacteria" id="SLM49031">
        <property type="protein sequence ID" value="SLM49031"/>
        <property type="gene ID" value="NSJP_2864"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2864"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01979">
        <property type="entry name" value="Phosphofructokinase_II_Short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011403">
        <property type="entry name" value="PPi-PFK_TM0289"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036482">
        <property type="entry name" value="PPi_PFK_TM0289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="11">
        <location>
            <begin position="5"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="178"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP" evidence="10">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi" evidence="10">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM49031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="420" mass="45391" checksum="058AAF06E634E1A4" modified="2017-06-07" version="1">MSTTIAILVGGGPAPGINAVIAAATVRCLAEGNTVLGVEHGFKRIMYGDVSRIVPLTLSHVDRLHFQGGSILKTARANPTKNQAHLLQTLRSLESLGATGLITIGGDDTCFSALTLERAAEGRLRVVHVPKTIDNDLDLPPGVPTFGFQTARHEGTHAVKSILEDASTTSDWFFVVAMGRKAGHLALGIGKAAGATLTLIAEEFPNRPVRLGQIADLVTGSIIKRLAQGREDGVVVLAEGLAEIIAPQDLAAVSTVSRDEHGHMELAELDLGHVLKGEVVKRLALCSLAPRIRVKDIGFELRCADPIPFDMEYCRDLGCCAAEYLMSGGTGAMVSIVEGKFRPMPFHGILDPVTGRTRVRMVDIEADSYRIARRYMTRLEREDFEDTERLTSVARAACATPEVFLNRFASVAEHERETRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I812</accession>
    <name>A0A1W1I812_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="9">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">alaS</name>
        <name evidence="12" type="ORF">NSJP_2958</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2958"/>
    <dbReference type="EnsemblBacteria" id="SLM49125">
        <property type="protein sequence ID" value="SLM49125"/>
        <property type="gene ID" value="NSJP_2958"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2958"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="11">
        <location>
            <begin position="3"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="730"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="565"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="569"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="667"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="671"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM49125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="877" mass="96396" checksum="F1F1C1F9A967D8C0" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I837</accession>
    <name>A0A1W1I837_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49166">
        <property type="protein sequence ID" value="SLM49166"/>
        <property type="gene ID" value="NSJP_2999"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2999"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="284" mass="31411" checksum="5D39687D219814F9" modified="2017-06-07" version="1">MFKIKKKPAKSKPPELYNIIEDYSEFDAPGNVTVCAMTLAEDLAMHAKILSESYQIPLDRMTSLLTEGGLYVYPQVGGVLTQGLFCCVVDPQGGLPKQTWVLDLMQFAEAEQVSRARSCSLQDAALEVFRRTLPDELKAKLERKNLGLDYRTVSPQVAKGGDIKYIDFRKDWSPHFKRLCIMPDGRLVETGGLQEFAQLHGITEAQAKTLIGEGGILEVGEEVLACQIVNGQPAVARFSAKNYVKAKELVTAKGLHLMDALSEIGYNDPAMMRGLMRKELTAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8F4</accession>
    <name>A0A1W1I8F4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ca(2+)/H(+) antiporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3117</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Ca(+)/H(+) antiporter that extrudes calcium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49284">
        <property type="protein sequence ID" value="SLM49284"/>
        <property type="gene ID" value="NSJP_3117"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3117"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="PTHR31503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="30"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="210"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="357" mass="37315" checksum="47937BDEF7B7BE44" modified="2017-06-07" version="1">MKDLFRSWLDILLIFVPVSVGLELIHADPLAIFICSALAIIPLAGVLGRATEHLSAHVGEGIGGLLNASLGNAAELIIALAALRNGLHDVVKASLTGSILGNILLVLGAAMIAGGVKYERQKFNQTAAGMGASLLLLAAVGLIIPALFHLTAASQGAAVERELSLEIAIVLFAIYVLSLVFSLKTHRHVYTGEEHGPADLGETPWTQTKSTVVLGVVTVLIAVMSETLVGALEPAAHRLGMTQLFVGVILVALVGNAAEHSTAVMVAMKNKMDLALSIAVGSSLQIALLVAPLLVFASYLFGKPLDLIFTPFEVASVTISVLIVGFVAMDGESHWMEGVMLVGVYAMLAVAFFFLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8S2</accession>
    <name>A0A1W1I8S2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49321">
        <property type="protein sequence ID" value="SLM49321"/>
        <property type="gene ID" value="NSJP_3154"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3154"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="101" mass="11246" checksum="7331C28BC18402DA" modified="2017-06-07" version="1">MKALLNVKELASALGVSVKSVQRAYRRKEIPVQWLCRTALFDLDDVRRAMTLNGERRFEAPVGSTDESGAAGGASRRRAGSNSPRTVKRGRKFQPSTRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8T5</accession>
    <name>A0A1W1I8T5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49279">
        <property type="protein sequence ID" value="SLM49279"/>
        <property type="gene ID" value="NSJP_3112"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3112"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="161" mass="17320" checksum="D8453532EB148571" modified="2017-06-07" version="1">MKKYHWMFDGARTLTLLALGLLSAGCQTFDSKVLEKNASSNELRKETTLDPVLPSGCPTVTMSLPEGRNKMEVSYREPTLDQNGIALTTLAFTTVYVSSVQSKTTAFRIWTNDARGGALVTVRDIPVQDREAGICVTATNWGRKESAPAAAAPQTGAAASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8V1</accession>
    <name>A0A1W1I8V1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized 17.2 kDa protein in melC2-rnhH intergenic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49309">
        <property type="protein sequence ID" value="SLM49309"/>
        <property type="gene ID" value="NSJP_3142"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3142"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="10"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="151" mass="17509" checksum="944250B673524E87" modified="2017-06-07" version="1">MSRIEESIDVNVPVRTAYNQWTQFEEFPRFMEGVRQVSQLDERRLHWKAELGGKEKEWDAEITEQVPDRRIAWTSRNGVGTAGVVTFHRLSDAQSRIMLQMEYDPEGFVEHVGDAVGIVTQRIIGDLQRFKTYIETRGRETGGWRGSIQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I904</accession>
    <name>A0A1W1I904_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent Clp protease adapter protein ClpS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">clpS</name>
        <name evidence="3" type="ORF">NSJP_3116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3116"/>
    <dbReference type="EnsemblBacteria" id="SLM49283">
        <property type="protein sequence ID" value="SLM49283"/>
        <property type="gene ID" value="NSJP_3116"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3116"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpS" evidence="2">
        <location>
            <begin position="28"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="98" mass="10436" checksum="98724720E226095C" modified="2017-06-07" version="1">MAESPTPVATPLTTETPSTSAGDGLEARVIVYNCDCHTYQQVIGLFCECIPGMTASRAFELAWKIDHHGEAVVFTGAWKQAEEIAGKLGNGGLRVAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I928</accession>
    <name>A0A1W1I928_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49500">
        <property type="protein sequence ID" value="SLM49500"/>
        <property type="gene ID" value="NSJP_3333"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3333"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033456">
        <property type="entry name" value="DUF5132"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17195">
        <property type="entry name" value="DUF5132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="89" mass="8632" checksum="96BC8B52CE65EAD8" modified="2017-06-07" version="1">MEAIITGVVGVVAGAVIAQAAPKIVEGPASLLRGLAREVIKGGLVIQDSAASLFSGSGNVLSDLVAEARAELKSGSAAATAPAKVGAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I977</accession>
    <name>A0A1W1I977_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3421"/>
    <dbReference type="EnsemblBacteria" id="SLM49588">
        <property type="protein sequence ID" value="SLM49588"/>
        <property type="gene ID" value="NSJP_3421"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3421"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005229">
        <property type="entry name" value="CHP00255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013551">
        <property type="entry name" value="DUF1732"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013527">
        <property type="entry name" value="YicC-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30636">
        <property type="entry name" value="PTHR30636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08340">
        <property type="entry name" value="DUF1732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03755">
        <property type="entry name" value="YicC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YicC_N" evidence="1">
        <location>
            <begin position="20"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1732" evidence="2">
        <location>
            <begin position="226"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="310" mass="34705" checksum="376521691017096F" modified="2017-06-07" version="1">MRTLSDLRALYVETERARMIRSMTGFGRQQAPWQDGSVAVEVRSVNHRFLEIACRLPRPLNHLEDTIKKAAQQVCARGRIDLTITVQSGKGRSHTVAVDQGLAKQYHQALRALKKTLKLSGSIDIGLIAGQRDVVSIIDQPVEDRKLSKLAQQLAVKALDDLVAMRRREGDALAKDMLARLGAIRERKTIVGAMAPRVVQAEFDRMRSRVEKLMGGEPPDASRLLQELAVYADRGDIAEEIVRLDSHMVQFEQTLNRSESIGKTLDFLLQEMGREVNTIGSKANDAEIAAQVVHMKAELERIREQVQNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I996</accession>
    <name>A0A1W1I996_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3441"/>
    <dbReference type="EnsemblBacteria" id="SLM49608">
        <property type="protein sequence ID" value="SLM49608"/>
        <property type="gene ID" value="NSJP_3441"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3441"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="42"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="463" mass="51490" checksum="1B9F0542EED73439" modified="2017-06-07" version="1">MYESFYSLKTKPFALLPDSDFLYAGSTHRAAYSLLEYGLLSQAPFVVLTGDPGMGKTSLLQKLMSEHRGKFSIGLVTNARYDVEHLLPWILLSLGLAKKRLDPVEAYHIFSEFLSQESRQHRRVILIIDEAQSLGAELLEELRLLSNMNDGKQLKLQIILSGQPDLQLLLKRIDMSQFAQRIVADYHLEPLTDVDTANVISHRLQVAGGQTGLFTKRACALVHRLTRGNPRLINQVCDIALTYGFAEQKRVITSKIVAQAALDRGRGGILPLAGKEDLVTLANAPEDAAEIETALPAAQAAVSNADTSIMRRERLPGIDYDEALELKKTGRLDEAVEIFERVAKNPAYWLRAYAQIGLCHRAMGNTDGALHAFRTALNDQSASGKEVLDVQYFLARTLEATGQQEEAMLLYRRVAQANSHYRDAAFRARDLGGRPRLKKQGKASADEDVSWIGNLQRLISSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9A1</accession>
    <name>A0A1W1I9A1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-alpha-glucan branching enzyme</fullName>
            <ecNumber evidence="3">2.4.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3292</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3292"/>
    <dbReference type="EnsemblBacteria" id="SLM49459">
        <property type="protein sequence ID" value="SLM49459"/>
        <property type="gene ID" value="NSJP_3292"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3292"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="6">
        <location>
            <begin position="300"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="804" mass="88552" checksum="BDBCD4085B7ADD46" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9C4</accession>
    <name>A0A1W1I9C4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Outer membrane protein, ompA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3471"/>
    <dbReference type="EnsemblBacteria" id="SLM49638">
        <property type="protein sequence ID" value="SLM49638"/>
        <property type="gene ID" value="NSJP_3471"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3471"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="3">
        <location>
            <begin position="175"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="294" mass="31363" checksum="11C29A6004ABD572" modified="2017-06-07" version="1">MIRAAILGAGGIALLLLAVVCIPRHFPQNPAPPMIPASFHARIENGTLTLRGTLPTTSSLGRILQGAHARYDAAHVQIVDQLTVDSKVSSARWIDPLPSVLPVLQQMNGRGSMIIDGRSLVMSGKVASEQAKASVLRAIAPITATGLELEDHILAAAAPSAPPGPARPPRASLQSRLNAVLSHNRIEFESNQASLTATGRATLDVLVPILRDAPPQAEIEIAGHTDGYGAPDYNLTLSRRRAEAVRDYFVKHGLTQHFTPVGYGSTKPHSNERTQAALKKNRRIELQVKGNGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9D7</accession>
    <name>A0A1W1I9D7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3491"/>
    <dbReference type="EnsemblBacteria" id="SLM49658">
        <property type="protein sequence ID" value="SLM49658"/>
        <property type="gene ID" value="NSJP_3491"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3491"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="4"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Sacchrp_dh_C" evidence="2">
        <location>
            <begin position="127"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="362" mass="39980" checksum="C4A06E59928652F7" modified="2017-06-07" version="1">MHHVLVLGAGKIGSLITCLLAGRDDYTLSLGDVTLDSPKRLVEDLELPRVTPYLLDARHPDSIGAFLKTHPVDAVVSSLPYFCNPLIAGLARTHDVHYFDLTEDVEVTCQVKSLSAGATRAFVPQCGLAPGFISIVAHDLMTHFESLDTVKMRVGALPVHPSNALKYSLTWSTDGLINEYGNLCYGIEQGERIPLQPLEGYETIELDGLLYEAFNTSGGLGMLADSYAGRVRTMNYKTLRYPGHCEKIHLLMKDLKLNEDRDTLKRILERAIPQTLQDVVLIYASVTGTREGGFFEENYVKKVYPQCIVGRPWSAIQVTTASSVCCVVDLVLQHPDSYAGFVTQETFGLQDFLANDFGACFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9J0</accession>
    <name>A0A1W1I9J0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49666">
        <property type="protein sequence ID" value="SLM49666"/>
        <property type="gene ID" value="NSJP_3499"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3499"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="98" mass="10835" checksum="57C8CAED2677B864" modified="2017-06-07" version="1">MAGGTETQVRDRLAWQRTVLANERTLLAYIRTALGFFIAGIPAVWWPDQPAIHVLGGVSLAAGVMCLGIGIHRFFTFQRMMIREVESSTVSQSIERTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9N9</accession>
    <name>A0A1W1I9N9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49641">
        <property type="protein sequence ID" value="SLM49641"/>
        <property type="gene ID" value="NSJP_3474"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3474"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="29" mass="3029" checksum="B065B53BA09F5575" modified="2017-06-07" version="1">MPFESGEFVVIVKGSGAGLIVNVYCLDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9P5</accession>
    <name>A0A1W1I9P5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease III</fullName>
            <ecNumber evidence="10">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">nth</name>
        <name evidence="12" type="ORF">NSJP_3422</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3422"/>
    <dbReference type="EnsemblBacteria" id="SLM49589">
        <property type="protein sequence ID" value="SLM49589"/>
        <property type="gene ID" value="NSJP_3422"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3422"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10576">
        <property type="entry name" value="EndIII_4Fe-2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="11">
        <location>
            <begin position="47"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM49589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="220" mass="24773" checksum="F111D04159CB1E4B" modified="2017-06-07" version="1">MIPKQLQQKARQERLGKIAENLIRSMPAAEMELDHRTPWELLIATILSAQCTDERVNRVTPALFRRYPTPADLGQASQRDVEEVIRSTGFFKSKAKNIIACGRAVEEKFHGKVPETMEELVGLPGVGRKTANVLLGNAFGKPAIVVDTHVKRVANRLGFTTSDDPTRIEQDLQRLLPPARWTAVSQRLLLHGRYVCTARRPQCERCPIYAHCTWKQKGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Q4</accession>
    <name>A0A1W1I9Q4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <shortName evidence="6">PBG</shortName>
            <ecNumber evidence="6">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="6">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">hemC</name>
        <name evidence="9" type="ORF">NSJP_3577</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="6">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3577"/>
    <dbReference type="EnsemblBacteria" id="SLM49744">
        <property type="protein sequence ID" value="SLM49744"/>
        <property type="gene ID" value="NSJP_3577"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3577"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="11"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="8">
        <location>
            <begin position="232"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="6">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="315" mass="34595" checksum="6126B248FB969FCD" modified="2017-06-07" version="1">MTPLTQARSRLVLGTRGSKLAVCQSEWVQARLKELAPDVDVTLRRIQTSGDKILDVPLAKIGGKGLFVKEIEEALLHREIDLAVHSMKDVPAELQPGLALLCVPRREDPRDALISRDGRSFKDLPHGARIGTSSLRRQAQLLRVRPDFSIEMLRGNLDTRLRKLREGQYDAIVLAAAGLRRLGWAKEITELLDFETCLPAIGQGALGIEGREDDDFVRSLLSGMEDRETRTTVMAERALLRRLQGGCQVPIAAYATMHGARVSIDALVAGLDGKEIVRERAEGAAEEAESLGVRVGERVLARGGDRILQSIYGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA04</accession>
    <name>A0A1W1IA04_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Guanine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">guaD</name>
        <name evidence="4" type="ORF">NSJP_3655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.4.3" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3655"/>
    <dbReference type="EnsemblBacteria" id="SLM49822">
        <property type="protein sequence ID" value="SLM49822"/>
        <property type="gene ID" value="NSJP_3655"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3655"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="159" mass="18282" checksum="43792C04ACA351BD" modified="2017-06-07" version="1">MDFVQQTIALARRNVEAGGRPFSCLIVKEGTILAEGVNLVAQTHDPTAHAEICAIRTATARLQTEHLTGCEFYILAHPCPMCLAAMYYCSPDRVVFITKRDDYAAFYRDDRKYISFETFYEEFAKPWDERRLPMTHQAHPESLSVYQRWKELNQASLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA11</accession>
    <name>A0A1W1IA11_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49719">
        <property type="protein sequence ID" value="SLM49719"/>
        <property type="gene ID" value="NSJP_3552"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3552"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="155" mass="15954" checksum="E53024F0533A69DE" modified="2017-06-07" version="1">MTSTALVTCLTGTSVFVALTMTSGASRTVDRSTGILSGGAAAGSPAWSGTGDSAEIGPAPWPGIGASSAEAAWRGTKMPSANTSARNPNETEHGDMRTSLWLEGCYFLRQLGLLTHGSTFPCAFPWNDVHSGVAAGSLPVYSGGTVMDSHHLPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA23</accession>
    <name>A0A1W1IA23_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49897">
        <property type="protein sequence ID" value="SLM49897"/>
        <property type="gene ID" value="NSJP_3730"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3730"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="431" mass="46939" checksum="32295175DF735876" modified="2017-06-07" version="1">MTHLRSTIQAVTGAESEEIVPVAWSFFYFFCLLCGYYILRPVRDEMAIEGGVQHLPWMMTATFVTLLVVTPLFGYLSSHVPRNRLLLSVYTFFGANLIGFFLLMISHTTPSWVARMFFVWLSVFNLFVVSVFWSFMADLFTPSQGARLFAVIAAGGSTGAMCGPVLAATVTYLAPIPWLMLVSAGFLAGCGFCIYRLHEWASARPGVQGVQSGHPLGGGMWEGVRLAVSSPYLLGICLYLFCLTTTATFLYLEQTRLVSEQIPSPEGRTRLFATIDLAVNVITFLTQLFVTGQVIGRLGLAAALVALPLASAAGFALIGAAPVLVFYALFTVVRRVGEYAVSKPAREVLFTVVTREEKYKAKNFIDTAVSRGGDAVTGWVVNAVKALGVSAAQISWILVPIACCWAWLGWSLARQEDRRRRAGTAASEATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA29</accession>
    <name>A0A1W1IA29_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3456"/>
    <dbReference type="EnsemblBacteria" id="SLM49623">
        <property type="protein sequence ID" value="SLM49623"/>
        <property type="gene ID" value="NSJP_3456"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3456"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="445" mass="48146" checksum="323834A644E3BF8A" modified="2017-06-07" version="1">MVSRLGSWAETVRRIPHAVSGVGRGESVMVLADQVLVSASNFLTTLILAKYLNPEDFGGFVLAWGVLVFLAGIQMALIVSPMQVRGPRLGCEDSAPYYDRVLQVALLFGLACVGVIAIPGVLLSLSIPDWTLGSLAVPLGIAALFVLAQDYLRRYFLTVRRTGSALLNDLCTHGFRLCALFLLATTSTLSAAGALWMVSAASAAALFIGIFQHEGVMRLRITQLKTAGTVARQHWEFGKWLVANNVAYWFGSQSVLYVVAAVLSVSAVGALNATLAILGAANILFLSMETLIPVRAAAEYARFGRAGLDGYLRRALLVGSLAVLILAAIAGLWSEYWLSLLFGETYRGYGWIVWWWGGYYLLGMLQRPTTAALRVVGDTKSIYLASSMGALATMVLGYPVIKHYGLGGAMLVLCLTQCFVLCSLRIRYMHTASEEHKPRLAHANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA66</accession>
    <name>A0A1W1IA66_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49914">
        <property type="protein sequence ID" value="SLM49914"/>
        <property type="gene ID" value="NSJP_3747"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3747"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="66" mass="7474" checksum="2DC449BBADF6D360" modified="2017-06-07" version="1">MQKQVGKIGAIRRELRGKACPCCGSRTYQLVLRSDLPAQSGKLFARCTQCHRPRGIDEDLGRILWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA90</accession>
    <name>A0A1W1IA90_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
            <shortName evidence="7">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">serS</name>
        <name evidence="10" type="ORF">NSJP_3743</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3743"/>
    <dbReference type="EnsemblBacteria" id="SLM49910">
        <property type="protein sequence ID" value="SLM49910"/>
        <property type="gene ID" value="NSJP_3743"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3743"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="PTHR43697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="171"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Serine binding" evidence="7">
        <location>
            <begin position="230"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="261"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="348"/>
            <end position="351"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM49910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="428" mass="48003" checksum="C1EE5AD1242D8B6C" modified="2017-06-07" version="1">MHDLRLLRDQLDDIRAQLGARGNDVQWDSLRKLIDERRTLTAYVEQLRHELKKGSDAVAQLKRSKQPADEAIASMKAVGERIGQGETDLRQVEDALKDLALRIPNIPHSTVPSGKEAADNVEVRRIGSPPSFTARPYSHWELGESLGILDFERAAKIAGARFAVLTGAGARLERALINFMLDLHTAQHGYREVLPPFMVNRSAMTGTGQLPKFEEDLFRLSEEDYFLIPTAEVPLTNLHREEILNEAQLPIRYTAYTPCFRREAGSYGKDTKGLIRLHQFNKVELVAFTMPQESSTELERLTGHAESILQQLGLHYRVMLLCSGDMGFSSAKTYDIEVWLPSQNQFREISSCSNFEGFQARRAGIRFKGAAGKKDARTEFVHTLNGSGLAVGRTVVAIMENYQQPDGSVLIPPVLRPYMGGLERISRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA92</accession>
    <name>A0A1W1IA92_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">acpP</name>
        <name evidence="4" type="ORF">NSJP_3516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3516"/>
    <dbReference type="EnsemblBacteria" id="SLM49683">
        <property type="protein sequence ID" value="SLM49683"/>
        <property type="gene ID" value="NSJP_3516"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3516"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="99" mass="11009" checksum="6B2AB6C5A65BA135" modified="2017-06-07" version="1">MTDRVVMEKIIAALAEYLRRDPLTIQENYHLRDDLGLDSMAVIELLYKIEENFNIQIPDEDLVGLTTVGSVAEYVQHRLAPAKPVASGPGKAKTKKSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAF2</accession>
    <name>A0A1W1IAF2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49849">
        <property type="protein sequence ID" value="SLM49849"/>
        <property type="gene ID" value="NSJP_3682"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3682"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="37" mass="4019" checksum="C6F024854CD298DD" modified="2017-06-07" version="1">MFYSGPTAKSSFLLIAIYPILGINLVLALSATWVFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAG0</accession>
    <name>A0A1W1IAG0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3808"/>
    <dbReference type="EnsemblBacteria" id="SLM49975">
        <property type="protein sequence ID" value="SLM49975"/>
        <property type="gene ID" value="NSJP_3808"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3808"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018763">
        <property type="entry name" value="DUF2334"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10096">
        <property type="entry name" value="DUF2334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="275" mass="30885" checksum="F04EAF9BFC5CA015" modified="2017-06-07" version="1">MHFCIRDDDTSFFTAPEDLERAYGEVTKHGPVSLAIIPFCRAGSSKGVPEKYRRRWSIHPLDENQALVDYLRDGIAAGRYEAMLHGYHHDQPDSQLEFADGRDLSERVRHGRAYLEDLLSAPVRVFVPPKNAIGKQGLHAIARERLNLGGVAGLRSGWSPFSPATWITWFRLRRWRARGGLGVPWILDLGDHKEIAGNPVTPSASLRLNECIFDQAIRVDGVFCAATHYWELDTSCQESGIATVREHLLRLIARASNDQKVVWRSVGDVVSSMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAH4</accession>
    <name>A0A1W1IAH4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucosyl-3-phosphoglycerate/mannosyl-3-phosphoglycerate phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.70</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpgP</name>
        <name evidence="1" type="ORF">NSJP_3839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.70" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3839"/>
    <dbReference type="EnsemblBacteria" id="SLM50006">
        <property type="protein sequence ID" value="SLM50006"/>
        <property type="gene ID" value="NSJP_3839"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3839"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050531">
        <property type="term" value="F:mannosyl-3-phosphoglycerate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051479">
        <property type="term" value="P:mannosylglycerate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07507">
        <property type="entry name" value="HAD_Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006381">
        <property type="entry name" value="HAD-SF-IIB-MPGP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01142">
        <property type="entry name" value="C2.B.2:_Mannosyl-3-phosphoglyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01486">
        <property type="entry name" value="HAD-SF-IIB-MPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="294" mass="32945" checksum="3028A8FFCC7821EB" modified="2017-06-07" version="1">MISSLSHDGSDTLLERPVTQFVLFTDLDGSLLDGMTYSFHAAIQALREVRARGIPLVLVSSKTRAEMEPLRARLDHRDPFIVENGAAVFIPQGRFDFPIERARKRSAYDVIELGLPYHMLRDVLKQIEEAVETPLRGFGDLSVGEIMRVTGLSKTDAELAKQREYDEPYLVEGPPSLVAEVCRQIIMRGLHWTKGGRLFHLTGRNDKGQAAALLLRCYQRQFRLQEGPIRIETIGIGDSLNDAPLLTMVDHPVLVQRLDGTYDPDVRVPGMIRADGIGPVGWNRAVLDILDRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAH7</accession>
    <name>A0A1W1IAH7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Archease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the archease family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3891"/>
    <dbReference type="EnsemblBacteria" id="SLM50058">
        <property type="protein sequence ID" value="SLM50058"/>
        <property type="gene ID" value="NSJP_3891"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3891"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="SSF69819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="5">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM50058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="144" mass="16141" checksum="BF7EAF5E6C4FC98E" modified="2017-06-07" version="1">MTFSFRFLDDVALADVAFDAEGDSVQAIFGAATQALLTALANPATVGSSWEQRIERRATDLPQLLFDWLSDIVYWKDAAGVVFHDAPLTMVRKGEQWVLTARLIGSPVDRERQELHNDVKGVTKHLYALRQTDGLWQVRVVLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAK1</accession>
    <name>A0A1W1IAK1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4136 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50077">
        <property type="protein sequence ID" value="SLM50077"/>
        <property type="gene ID" value="NSJP_3910"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3910"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025411">
        <property type="entry name" value="DUF4136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13590">
        <property type="entry name" value="DUF4136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010712510" description="DUF4136 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4136" evidence="3">
        <location>
            <begin position="42"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="216" mass="22511" checksum="9B7DA855D0639EF8" modified="2017-06-07" version="1">MKDVLRVSLLLCGLLLTAGCAQTVVVDASGTTKSGAVPPHVTYVVLPTAEVEKDQAFPAYAALVAGKMDDLGYKKTSEKTAQLGVFLAYATHEGASAAPAKSGNAGANMGGMGPGSPGGSGYGMSSGPSQDTSGQRTYTNQLVVVVVDLQKSSNTGPVVELWRGETTNTSRSKNFEQVAPLMVDAAFQHFGESTPSAVRHQFTLEDGKKPQEMKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAN9</accession>
    <name>A0A1W1IAN9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative Lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_3782</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3782"/>
    <dbReference type="EnsemblBacteria" id="SLM49949">
        <property type="protein sequence ID" value="SLM49949"/>
        <property type="gene ID" value="NSJP_3782"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3782"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032807">
        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
        <property type="entry name" value="GNVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="8">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="10">
        <location>
            <begin position="383"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_31" evidence="9">
        <location>
            <begin position="578"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="189"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM49949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="769" mass="86732" checksum="92C372B122438C00" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAU6</accession>
    <name>A0A1W1IAU6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50122">
        <property type="protein sequence ID" value="SLM50122"/>
        <property type="gene ID" value="NSJP_3955"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3955"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="89" mass="9838" checksum="81FC19599E10C9CA" modified="2017-06-07" version="1">MPNLMRILVPVSLLLVSCAEGRWAHPTKDEVQAQRDWEVCKAEVLAGTEHQKDTMAGSINLSGCMQSKGYRYVEDETPRSTGSTTPSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAW2</accession>
    <name>A0A1W1IAW2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AhpC-TSA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50125">
        <property type="protein sequence ID" value="SLM50125"/>
        <property type="gene ID" value="NSJP_3958"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3958"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AhpC-TSA" evidence="1">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="171" mass="19315" checksum="B58C5676BFBA2519" modified="2017-06-07" version="1">MRLNATNMLDFRAPALIGGQLTYLSGRQFVGRVVVICFLPDQGIIAAAETLDEQADRFRRIDVDLLIVGSDACLHYQVWHEREKRHRATVLADPRRRLHRMFGVTASSAASRCATFLVDEDGIVRLRWRHDFSPGDLQAIRNLIVLNRLSVGKAGEAWASQADSRREFLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAX9</accession>
    <name>A0A1W1IAX9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MbtH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3904"/>
    <dbReference type="EnsemblBacteria" id="SLM50071">
        <property type="protein sequence ID" value="SLM50071"/>
        <property type="gene ID" value="NSJP_3904"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3904"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="80" mass="9371" checksum="90EA7EE7DDD9C18B" modified="2017-06-07" version="1">MQNEEREDTTVYKVVVNHEEQYSIWPAYRDNPLGWKDAGKTGLKAECLAYITEVWTDMRPLSLRQWMDQQAKSEKTATSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB30</accession>
    <name>A0A1W1IB30_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetyltransf_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_4035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FemABX family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4035"/>
    <dbReference type="EnsemblBacteria" id="SLM50202">
        <property type="protein sequence ID" value="SLM50202"/>
        <property type="gene ID" value="NSJP_4035"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4035"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017469">
        <property type="entry name" value="PEP-CTERM_FemAB-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03019">
        <property type="entry name" value="pepcterm_femAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="2">
        <location>
            <begin position="152"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="344" mass="39099" checksum="BCD0DBD3368FDD4C" modified="2017-06-07" version="1">MNVITLNTATDAALWDAFVLSRPEASGYHTLAWREVVTRVFGHPTFYLMAKDGQDMVRGVLPLVLTKSPLFGSFLTSLAFFNYGGILAEDRMATEKLLARAGDLARELGAGHIELRQTAPLETDWPVGQHKVSMRLALPSDPEALFKAYPSKLRSQIRRGQKEGMEVRIGAEELLNDYYSVFSRCMRDLGTPVYAKGFFRAIVDAFPKETRLFVVSLQQQPLAAGLVYGFRRVLEIPWAASDKRYGRLAPNMLLYHAVLEYACREGFTEFDFGRSSVDSGTYRFKQQWGAQPRPLYWYYWLSQGREMPRLSPDNPKFKVAISLWQRLPLFAANLLGPHIVKYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB81</accession>
    <name>A0A1W1IB81_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4004"/>
    <dbReference type="EnsemblBacteria" id="SLM50171">
        <property type="protein sequence ID" value="SLM50171"/>
        <property type="gene ID" value="NSJP_4004"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4004"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007813">
        <property type="entry name" value="PilN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05137">
        <property type="entry name" value="PilN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="210" mass="23389" checksum="C077BFC70A8CB110" modified="2017-06-07" version="1">MSMLKHSSVVALGRIFLPGSSSTQYFHLDLASRYRWYVKPVRAGLATLCILACLWIAWTLALTMNRLAELREMQTRLDQIRDQDRQLVAGARKEGIDLSAHSLNILPAEVSLANELLAKRNFSWTQFLSGLEEAIPQRVSIKSVRLDSVGRVVHLTGAAITVEDITALTMKLQDHPVFRDPVLGQHHVGGDGLVEFDLSLKYNREKASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBA4</accession>
    <name>A0A1W1IBA4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_4119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4119"/>
    <dbReference type="EnsemblBacteria" id="SLM50286">
        <property type="protein sequence ID" value="SLM50286"/>
        <property type="gene ID" value="NSJP_4119"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4119"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021457">
        <property type="entry name" value="DUF3108"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11306">
        <property type="entry name" value="DUF3108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="258" mass="28763" checksum="9A6A4E45729198EE" modified="2017-06-07" version="1">MCPRPWLLAALLLASFLGSTVLTWAETRPLLPAVQVGERLTYELTWLNILAGTAVLEVAEGNSNAQASLKLVMTAQSSPKITRFYPVDNRVESWVNPDTFLSEHMIFHRREGKRKNDFDYTFHHDQGSVTAVKDGVEETLPIPPGTFDAISCLYYVRSLPQFVPGTTESLSVHHDKKNYKLEVRVEGLETIKGTWGKAEAVRLLVIMPFQGIFLNQGNIRVWLTNDGRRIPLRMKARVIIGSIVADLVSGLPGGDSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBA6</accession>
    <name>A0A1W1IBA6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein CapL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">capL</name>
        <name evidence="5" type="ORF">NSJP_4012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4012"/>
    <dbReference type="EnsemblBacteria" id="SLM50179">
        <property type="protein sequence ID" value="SLM50179"/>
        <property type="gene ID" value="NSJP_4012"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4012"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="319"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM50179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="433" mass="47162" checksum="6392EBA5FC6BF0AC" modified="2017-06-07" version="1">MGSQTVHARKVAVVGLGYVGLPIAVAFGKRGDVVGFDINKVKINELRKGFDRTGEVSETDLKSARIQFTSEPADLKAADFIIVAVPTPINEALQPDLTALCKSSELIGANLSAGSIVVFESTVYPGATEEVCQPILEKTSGMKCGVDFKLGYSPERINPGDKEHTLEKIVKVVSAQDAESLEIVANTYGLVVKAGIHRASSIKVAEAAKVIENTQRDLNIALMNELALIFHRLGIDTKSVLEAAGTKWNFLKFSPGLVGGHCIGVDPYYLTSKAESVGYHPQVILSGRRINNGMGKFVAEQTMKRLSQLNRPVNDLKVAVLGLTFKENVPDLRNSKVPDIIHELKEYGVQVLVHDPIAESEEAVEEYGIHLSKWEQLKDVDGIVLAVAHRAYADMDTQKLLSPLGSQRDGVVIDVKCVLDRAKLPASIKYWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBB4</accession>
    <name>A0A1W1IBB4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4147"/>
    <dbReference type="EnsemblBacteria" id="SLM50314">
        <property type="protein sequence ID" value="SLM50314"/>
        <property type="gene ID" value="NSJP_4147"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4147"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="25"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="389" mass="43331" checksum="C52615D7F92FEF3C" modified="2017-06-07" version="1">MPLLRNRYRNFCMIRIVHIISNLEVGGAEMMLAQLVTGMDRGRFHNTVISLTDRGQLADRIESSGIAVHSLGMKRGRPDMASLPKLIRSLRDAQPTIVQSWLYHADLISLLAARFIKSTRLVWNIRCSDMQLKYYPFQTRCVRQMLCWCSRIPVAIVTNSEAGRRIHEMFGYRPRRWAYIPNGFDTNRFRPDPVAARKLREELGVPNDVRLVALIARCDPMKDHTTFLDAAKRIVLLRPKVHFLLAGKYTHMLEPAVSLAGLEKQVHLLGLRHDIDRLFAGADVACLSSAFGEGFSNVLGEAMACGVPCVTTDVGDARTIVDNTGLVVPPRDPEALACAVINLIDRDAASRIALGTAARARIQSRYSLTSVINAYQAFYADISNDSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBC7</accession>
    <name>A0A1W1IBC7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4032"/>
    <dbReference type="EnsemblBacteria" id="SLM50199">
        <property type="protein sequence ID" value="SLM50199"/>
        <property type="gene ID" value="NSJP_4032"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4032"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045781">
        <property type="entry name" value="SxtJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19588">
        <property type="entry name" value="SxtJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="132" mass="14804" checksum="E9DFE15689A08A1A" modified="2017-06-07" version="1">MEREEISKAVLRQFGLLVGGVFLLIGLFPFVWRQDPVRVWAVGLGTLLAATGLVAPGLLREPYRGWMLIGHVLGWINTRIILGVLFYGIITPMGVIMKLTGRDPMRRGFDPGATTYRVTRPPRPATHMKNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZS8</accession>
    <name>A0A1W1HZS8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46251">
        <property type="protein sequence ID" value="SLM46251"/>
        <property type="gene ID" value="NSJP_0079"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0079"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021830">
        <property type="entry name" value="DUF3422"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11902">
        <property type="entry name" value="DUF3422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="462" mass="51793" checksum="C0EFDFB344A352AF" modified="2017-06-07" version="1">MTERKFSQSGTEALLKKLHERPQTPLAEWLRAPAHVHYMAFRMSDPPVQRKASREEFESILSAFSVPDDHIFLHETFGYGVKETATGERLIIVWQAHTEYYNYQLWHLPLPTWAEAAFGSLTFPGYQFPVTPLGTEVCRLDILLTLDAVPSRERMKSLLPGPVVYGSRVLDEQTTVVTSFTPDEQGRERYWVSVGQPQGVASRLKDIVDAVVRIETYYHLLLMQKPLFSAAVDQVYKFEQVHLKQREVISGHIGHADSQTLQRWLNSLTQDLLKTNRIAGRLHFELSASLPYDKIVHATLNSLAERPIDSYRPVSDYVLGGITGVAEGYQQLLRRIDTLRGGFEGIISIIRARVDLILEAQNLALLQSVDKTTKSQVILQHTVEGLSVIVIAYYLAGLAGYILKGLYEAGLIKNANIASAVFVPIAIGLAFVITTVSRTYLHRKLAGGHAPQEEHKDDPQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZZ6</accession>
    <name>A0A1W1HZZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46330">
        <property type="protein sequence ID" value="SLM46330"/>
        <property type="gene ID" value="NSJP_0158"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0158"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="74" mass="8061" checksum="A333D315B424D41F" modified="2017-06-07" version="1">MKGVQEKETRHIDVALSGNFVGSQTQVATTFASSAAPSPGARVQDNVIIFIRRNPTWVRRFTSVGCPIRQLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I002</accession>
    <name>A0A1W1I002_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_0130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46302">
        <property type="protein sequence ID" value="SLM46302"/>
        <property type="gene ID" value="NSJP_0130"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0130"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="242"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="345" mass="39240" checksum="E2CA52BCCCE878AE" modified="2017-06-07" version="1">MKALMSVGALVGVVGLLLLVGMIFDIVPSNTVRLVEGYMPMQMLTELAIFVAGFTGLSYMLNAMGMGIPRFWQGITFWAFILLYLKFRVYPPIPFSVRAMYGTVSLVAVFMWMSANEEDWRKFKQPIMNVMDAQTGMNKMLRYAYLILLPILIGGFSYNAMVPKSEEPIELRTVHPAPPASTKVHGKTYVLQTSQNPFRVNPEGKYDQEYTNANIVEQGMGRLMKPNANPWDQNAAGYLKYVREGGEIFFQNCHFCHGDNLNGRGLHAFAFNPIPANFTDPGTIAQLQETFIFWRVSKGGIGLPNEGFPWASVMPPWEQHLTVDEIWKVILFEYWHTGYYPRTWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I035</accession>
    <name>A0A1W1I035_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46368">
        <property type="protein sequence ID" value="SLM46368"/>
        <property type="gene ID" value="NSJP_0196"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0196"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="243" mass="26660" checksum="8E2F6FFBDC4A58DF" modified="2017-06-07" version="1">MRDRPLVRRTLMMLLTVGLVTLSGCKPDDSPLRADNDQLKKQLARQESLVSSLQDGNKVMQQQIDLLNQELRDAKKAADSAKSEARAAADQLDTQLIQARKLTADIKRTAVEQAAQSIHVDTKGSQMDDTPHPLSTVAKTVEDALGRNGYQVKVSVRTEQKAVYVTERKVSNPVSLEVAGFRNQYVVSLQAQPTNLTRLTVKADFEKLAQGGRILSVSADETAEIERRLIGEISKALAAPSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I082</accession>
    <name>A0A1W1I082_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5069 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46377">
        <property type="protein sequence ID" value="SLM46377"/>
        <property type="gene ID" value="NSJP_0205"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0205"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031849">
        <property type="entry name" value="DUF5069"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16798">
        <property type="entry name" value="DUF5069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5069" evidence="1">
        <location>
            <begin position="5"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="146" mass="16341" checksum="17AC34FA7F18D986" modified="2017-06-07" version="1">MTQGRYPRSPKSLLGGIAHLGRFIDKIRLRNAGLIQDYNYITVGFDKYLIDFLGIDAKAFEQRTLAGGTDDELLAWVAAHGKKDLTQDEVVQWSRGLLTSAPKDDPARQRFQNRLKEVAAKRGVAVSALPPVSTWADVIELDEERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0E2</accession>
    <name>A0A1W1I0E2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46466">
        <property type="protein sequence ID" value="SLM46466"/>
        <property type="gene ID" value="NSJP_0294"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0294"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="27" mass="3046" checksum="EE24F3F2853C9FBC" modified="2017-06-07" version="1">MVTLAIGGNAYEKRGDSYGQQSRRYPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0M8</accession>
    <name>A0A1W1I0M8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46558">
        <property type="protein sequence ID" value="SLM46558"/>
        <property type="gene ID" value="NSJP_0386"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0386"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="88" mass="10000" checksum="8CC85176CBF003D2" modified="2017-06-07" version="1">MKTVIHQGYTIKSFPQHGRTFNEWTISLEIFWRHKGTTRTRSFTADLPYGSEEEADLHGISYAQRIIDGNVPGLSVNETHASPLTCHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0N2</accession>
    <name>A0A1W1I0N2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46560">
        <property type="protein sequence ID" value="SLM46560"/>
        <property type="gene ID" value="NSJP_0388"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0388"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="103" mass="11794" checksum="B5BD3A48AF304693" modified="2017-06-07" version="1">MRKQGGYESGTWGSHESLDEVRCAKWLPQMLANAITMLRSNDRVKIIKYIQWLEIQNSRDAERTSEDSGDPIAPEHHSRNERRRRGGHYTNLLITGLSAASSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0T8</accession>
    <name>A0A1W1I0T8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46463">
        <property type="protein sequence ID" value="SLM46463"/>
        <property type="gene ID" value="NSJP_0291"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0291"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="64" mass="7306" checksum="64B6E77B5AE4497D" modified="2017-06-07" version="1">MSFDGANRLLLDLGCLHKTSKYNTPGKTGGIAKALESRWGHQSLCTTHQELKQYLETHLWVQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Y9</accession>
    <name>A0A1W1I0Y9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 10">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nadB</name>
        <name evidence="13" type="ORF">NSJP_0498</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of L-aspartate to iminoaspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0498"/>
    <dbReference type="EnsemblBacteria" id="SLM46670">
        <property type="protein sequence ID" value="SLM46670"/>
        <property type="gene ID" value="NSJP_0498"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0498"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 10" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="11">
        <location>
            <begin position="13"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="12">
        <location>
            <begin position="432"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM46670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="547" mass="59389" checksum="E9B827548064FEFD" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Z5</accession>
    <name>A0A1W1I0Z5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-type ATPase subunit b</fullName>
            <shortName evidence="11">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">atpF</name>
        <name evidence="14" type="ORF">NSJP_0490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="10 11">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0490"/>
    <dbReference type="EnsemblBacteria" id="SLM46662">
        <property type="protein sequence ID" value="SLM46662"/>
        <property type="gene ID" value="NSJP_0490"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0490"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="36"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM46662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="168" mass="19404" checksum="20E5879FD250B307" modified="2017-06-07" version="1">MPQFESHFFSSLIFWEIVSFAILFFILYKYAFPGILAVLEEREKKIRDSLDQAERHRSEAERKLKDYEAKLSAASKEAEGVLAAAKERAQRLLEENEQRLTQEAERIKGDATREIEHERRKAIQEIRSQTTDIALMVAEKVVQRSLNDTDHRRLADEALDALAKASAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1D2</accession>
    <name>A0A1W1I1D2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46791">
        <property type="protein sequence ID" value="SLM46791"/>
        <property type="gene ID" value="NSJP_0619"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0619"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="105" mass="11923" checksum="04D16FD2E419ACD3" modified="2017-06-07" version="1">MIWDDGIEEPKQADGWYLYRPLPTSTPVPVKVRTIGRLKYVAQYVGHPEVGNRRLRECHGTFLRPLAVHEIPCAHMETLTLNALPEWKDSEEWLCPQCGAVLGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1P0</accession>
    <name>A0A1W1I1P0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46907">
        <property type="protein sequence ID" value="SLM46907"/>
        <property type="gene ID" value="NSJP_0735"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0735"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="246" mass="26978" checksum="B9F8A7BF8B8E2EA6" modified="2017-06-07" version="1">MLPARPPLRVLHSKKGECGTTLMELLMATAAGFIILSAAWQTLSFFQRQFALQQAALSRQQDLRLGLEVLEQEIHQAEADSVSVMGPDEIEFGANVNGLVTTVTAPVASGATSLRVDDGRGWAERKTIVVSWNDHNEVMTLSRDGQRTLLTLTQPIAISIPTGASVSIRNRVRYYSKQDDQGNKRLLRMVDGGASVLFADVQAAKFSYWDEDGRTVNQPGRLKRVVVDVILRGMGTRAVRGISLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Y6</accession>
    <name>A0A1W1I1Y6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47018">
        <property type="protein sequence ID" value="SLM47018"/>
        <property type="gene ID" value="NSJP_0846"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0846"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="66" mass="7270" checksum="39478D9CA7C8E144" modified="2017-06-07" version="1">MQGQSQWGSPIKVWILKIMVETLAMSQDKVSSRRQFAQSPTELTVEEGGSSGSASSAMFQQDISQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I227</accession>
    <name>A0A1W1I227_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">der</name>
        <name evidence="11" type="ORF">NSJP_0873</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0873"/>
    <dbReference type="EnsemblBacteria" id="SLM47045">
        <property type="protein sequence ID" value="SLM47045"/>
        <property type="gene ID" value="NSJP_0873"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0873"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="15"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="188"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="68"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="194"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="241"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="306"/>
            <end position="309"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM47045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="450" mass="49766" checksum="054B9849CD459494" modified="2017-06-07" version="1">MSSQPTLNSLMSPMPLVAIIGRPNVGKSTLFNRILGSRTAIVDDVPGVTRDRNYADTNYRNRPFRLIDTGGLEPAASDGMLALIRRQSELAIAEADVLILLMDGRAGLMPQDQEVIRLLRGTTKPLFVAINKIDTPKTEVLVADFYQLGIDSLFPISAEHGIGVADLLDALYPLLSDQQDPEEQNPVPRVAVVGRPNVGKSTLVNAVLGEERVVVSDVPGTTRDAVDSLATYEGRQYLFTDTAGIRRRGKVDRGIEGYSVARSLRAIGRSDVAVLLLDGEEGITEQDTKISGLVIRQGRACLMLVNKWDLHEGDAQARQRFERDLKRRFPFLTWAPVLFGAAVKPGSLRHLFPTIDDVYASFTRRIPTGELNQLLQTILATHPLPSRKGKPTKITKSAFMTQVATRPPVFALFVGHPENMTPAYLRFLEHRLREEYGFAGTPIRLLVRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I229</accession>
    <name>A0A1W1I229_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aspartokinase</fullName>
            <ecNumber evidence="13">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lysC</name>
        <name evidence="16" type="ORF">NSJP_0747</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="13"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0747"/>
    <dbReference type="EnsemblBacteria" id="SLM46919">
        <property type="protein sequence ID" value="SLM46919"/>
        <property type="gene ID" value="NSJP_0747"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0747"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="15">
        <location>
            <begin position="264"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="15">
        <location>
            <begin position="344"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="173"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SLM46919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="413" mass="44303" checksum="A648AA92CC91DB23" modified="2017-06-07" version="1">MSLIVQKYGGTSVGTVERIHRVADNVERACKDGHQVVVVLSAMSGETDRLLRLAHEMAPLPDERELDMLLSTGERVTIALLAMALRSRHLDARSFTGRQVGILTDSAHTKARITKVTAERIRESLTRGVIPVVAGFQGINQQSDVTTLGRGGSDLTAVALAASLKADRCVIFTDVDGVYTTDPNIVPSARRIDKISYEEMLEMASLGAKVLQSRSVEFAAKFNVPLEVNSSFKEGKGTLVTREDRDMEAVAVSGVTGDRNQAKVTIVGVPDKPGIAAGLFGPVAKANILVDVIIQNMSQAALTDISFTIPRVDVNKAVPLIQDVARTIGAKSVSVTEAIAKVSLVGVGMRSHSGVAAKMFEVLSQEGVNIIMISTSEIKISCVIDEKYLELAMRSLHSAFGLDQPRNDDRAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I232</accession>
    <name>A0A1W1I232_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">tatA</name>
        <name evidence="9" type="ORF">NSJP_0711</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a complex with TatC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0711"/>
    <dbReference type="EnsemblBacteria" id="SLM46883">
        <property type="protein sequence ID" value="SLM46883"/>
        <property type="gene ID" value="NSJP_0711"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0711"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="88" mass="9239" checksum="2309B67E31BF1123" modified="2017-06-07" version="1">MFGSFGWMELLLILIIVLIIFGAGKIPQLGEGLGKAIKGFKKSVNEADAIDVTPPPDAPPPAQQQVTQNQSTPSADAPAQQGQQVKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I233</accession>
    <name>A0A1W1I233_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Phosphoglycolate phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.18" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0904"/>
    <dbReference type="EnsemblBacteria" id="SLM47076">
        <property type="protein sequence ID" value="SLM47076"/>
        <property type="gene ID" value="NSJP_0904"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0904"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="215" mass="24016" checksum="48FA53332ACE76F5" modified="2017-06-07" version="1">MGKTPVDLLIFDLDGTLIESKWDIAASVNLTLAELGLPQRPLEEIFGFVGDGVKKLLRQAVGDDNPDRFDEALRVFRGHYLAHCLDRTRFYPGIERMLQHFGRTSKAVATNKSIEFTNVILQGLGAQHFQFVVGGDNGFGLKPEPGMLRHIMERLNASPERTVLVGDSTNDINGGHNAGIRVCAVGYGMGNRERMTACRPDWFIERPEELMEIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2D0</accession>
    <name>A0A1W1I2D0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MEKHLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47131">
        <property type="protein sequence ID" value="SLM47131"/>
        <property type="gene ID" value="NSJP_0959"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0959"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013978">
        <property type="entry name" value="MEKHLA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08670">
        <property type="entry name" value="MEKHLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEKHLA" evidence="1">
        <location>
            <begin position="17"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="159" mass="18277" checksum="8926E286EA5439AE" modified="2017-06-07" version="1">MDDTAGSSGWATPSTVQWCRWLLDSYRHWAGEELIERAGTPEVQAHRLFDAPFVVVSHGIEEDPILNYGNRRALDLWESTWEQLVTTPSRMTAEPVHQDERRRMLETARSCGFFSDYRGVRISLTGRRFRIEGACVWTVMDARAVRVGQAASFSQWTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2G3</accession>
    <name>A0A1W1I2G3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1026"/>
    <dbReference type="EnsemblBacteria" id="SLM47198">
        <property type="protein sequence ID" value="SLM47198"/>
        <property type="gene ID" value="NSJP_1026"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1026"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSDH" evidence="1">
        <location>
            <begin position="166"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="388" mass="43177" checksum="878A065D5975A676" modified="2017-06-07" version="1">MQKDRDRRRYRDMATVRVTAGSRRRSGWWMLWLFLLMTPAEAASLPLDHITLPPGFTISIYADDVPNARGMALGRNGVLFVGSKEKGNVYAVVDKDGDQRADQVFTIAGGLQMPVGVAYRNGALYVSSVDRILRFDGIEERLANPPPPVTVTDRFPHDKQHGWKFIAFGPDGKLYVPVGAPCNICEPDPDRYALIARIDADGGGHEVVARGVRNSVGFDWDPATRELWFTDNGRDWLGDDQPPDELNHAPKAGMHFGYPYCHGGTIADPEFGKRPCREFTPPAATLGPHVASLGMRFYTGAMFPSEYRRRIIIAEHGSWNRTEKNGYRLTVVSRDDNGTLSYSVFAQGWLRGQQAWGRPADVLVMPDGALLVSDDLAGVIYRISYHEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2H4</accession>
    <name>A0A1W1I2H4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative monovalent cation:proton antiporter (CPA2 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybaL</name>
        <name evidence="7" type="ORF">NSJP_1020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1020"/>
    <dbReference type="EnsemblBacteria" id="SLM47192">
        <property type="protein sequence ID" value="SLM47192"/>
        <property type="gene ID" value="NSJP_1020"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1020"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004771">
        <property type="entry name" value="K/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00932">
        <property type="entry name" value="2a37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="6">
        <location>
            <begin position="412"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="544" mass="57666" checksum="A6629096BA03A2E2" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2K6</accession>
    <name>A0A1W1I2K6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucyl/phenylalanyl-tRNA--protein transferase</fullName>
            <ecNumber evidence="4">2.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L/F-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Leucyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phenyalanyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">aat</name>
        <name evidence="5" type="ORF">NSJP_0881</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:50416"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12673"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64719"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:133044"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:12340"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12670"/>
            <dbReference type="Rhea" id="RHEA-COMP:12671"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:65249"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:133043"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) = an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:43632"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10637"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83561"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the L/F-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.6" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0881"/>
    <dbReference type="EnsemblBacteria" id="SLM47053">
        <property type="protein sequence ID" value="SLM47053"/>
        <property type="gene ID" value="NSJP_0881"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0881"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008914">
        <property type="term" value="F:leucyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00688">
        <property type="entry name" value="Leu_Phe_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004616">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042203">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042221">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30098">
        <property type="entry name" value="PTHR30098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03588">
        <property type="entry name" value="Leu_Phe_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00667">
        <property type="entry name" value="aat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="231" mass="26163" checksum="A4FDD67447AF4AB6" modified="2017-06-07" version="1">MFRLSSNPCDLRFPPVEAAESDGLLAVGGDLSPERLLAAYRRGIFPWYQDDQPILWWSPNPRAVLFPHKLHVSRSLTRRIRRGDFTVTLDTCFRAVMTHCAGPRPQYPEGGTWITREMQDAYATLHEMGYAHSIETWQQGRLVGGLYGVALGGAFFGESMFSHTADASKVALTVLVRQLQAWGFAVFDCQQASPHVMRFGAEEIPRREFVSRLESACAHPDRRGRWRIDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2R9</accession>
    <name>A0A1W1I2R9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1126</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1126"/>
    <dbReference type="EnsemblBacteria" id="SLM47298">
        <property type="protein sequence ID" value="SLM47298"/>
        <property type="gene ID" value="NSJP_1126"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1126"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="33"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="172"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="241" mass="26435" checksum="A79C5C40E40D1225" modified="2017-06-07" version="1">MKRPEELYDDGGVPERSPVASELGSAKPMKTARVLLVDDHPLVLESIRQLLDPHFTIVGTIQDAGDIIGKAVECRPDVILLDACMPGMSGFVATRQLKKLLPSVKIVLVTMLTEAVSISEAFRAGATGYVLKQSASDELRAAIDSVLANKRFLSSKIDPEVREAMEHEWFRPEGFSSDLTARQREILVLLADGRSTKLIAQELKISMKTVEFHKANITRKLGVHTTSDLIKFALAQGITSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2V2</accession>
    <name>A0A1W1I2V2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RND efflux system, membrane fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ttgA</name>
        <name evidence="4" type="ORF">NSJP_1037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1037"/>
    <dbReference type="EnsemblBacteria" id="SLM47209">
        <property type="protein sequence ID" value="SLM47209"/>
        <property type="gene ID" value="NSJP_1037"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1037"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010728876" evidence="2">
        <location>
            <begin position="23"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="3">
        <location>
            <begin position="67"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="395" mass="42657" checksum="6B661B3071A8A241" modified="2017-06-07" version="1">MTYMNNRPIGLITVLAAGLVMAAASGCKEQADSAPAQQLPQVEVIAVSTQTVPDEPEFIGQAEASRPVEIRSQVTGILKAVMYSEGREVKKGDRLYQIDPVPFQAAAASAKAKIAQAEAKVVQAKQDLARVKPLLLEQAVSQKDVDDAVAEDLSAKAALQGAKADLIKAQFDLDNTLITAPIDGMIERSRYYEGRLVSAQTDLLTVVHRVDPMYVVVSVPETFFLKRSHDIEAKKINHPGAYELRGALTFMDGTAYPYEGVLDLMEPGMRTETGSRIERMTFQNPQRTLLPGQFVKVKFKGDAKPNAVLIPQRSVLQGPQGPFVYVVGSEERIEIRPVEASVWQGDQWLIDSGLKAGERVVVNGLMKIGPGAPVKAVPMGTVAEPDAASAPAKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Z2</accession>
    <name>A0A1W1I2Z2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Response regulator, CheY-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1214"/>
    <dbReference type="EnsemblBacteria" id="SLM47386">
        <property type="protein sequence ID" value="SLM47386"/>
        <property type="gene ID" value="NSJP_1214"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1214"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="137" mass="15313" checksum="ADEEF6EEFB8726A5" modified="2017-06-07" version="1">MDGYGKRVLIVDDNDDTSEILAGLLGRAGYNVHFAADGLYALEEMNKRHLDAVISNDRLPRMDGREFLLLSQATWPDTPVIMLSNETDGVERQMIELGAFAWVRTPYDHHVILSVLLSAVRQPLDTHREPAAARMPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I331</accession>
    <name>A0A1W1I331_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47402">
        <property type="protein sequence ID" value="SLM47402"/>
        <property type="gene ID" value="NSJP_1230"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1230"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="81" mass="9296" checksum="CE5D7342A967B9D8" modified="2017-06-07" version="1">MLHVVLESPFQLTYNRSRYKVTMPFTVHPFLRMPLCSPWTIKSKTLRASPWSGMSGRWTDDSLRFAASSWVGLLAHGAWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I352</accession>
    <name>A0A1W1I352_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47436">
        <property type="protein sequence ID" value="SLM47436"/>
        <property type="gene ID" value="NSJP_1264"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1264"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="27" mass="3091" checksum="4AC0371E28E0E938" modified="2017-06-07" version="1">MQRTNDSVLSDLSGKDIIVFFPILPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I353</accession>
    <name>A0A1W1I353_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47437">
        <property type="protein sequence ID" value="SLM47437"/>
        <property type="gene ID" value="NSJP_1265"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1265"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="61" mass="6952" checksum="8FD6D569CDE5C60F" modified="2017-06-07" version="1">MGSLLKLHFVGNRCNRNTPKRIAMPHFRDANSELQVEVSVLTGVSEHTNRRTLTGECEDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I398</accession>
    <name>A0A1W1I398_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47487">
        <property type="protein sequence ID" value="SLM47487"/>
        <property type="gene ID" value="NSJP_1315"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1315"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="88" mass="9966" checksum="1A23DC0CB465B175" modified="2017-06-07" version="1">MIRKVCTESIRDVRARFYRTARSLTRILGSSYNAAPSGLHGYVSRFDDYGRLTWTRDETAVTRAPLSGALNMPVNEAVESLRTRRTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3A3</accession>
    <name>A0A1W1I3A3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47482">
        <property type="protein sequence ID" value="SLM47482"/>
        <property type="gene ID" value="NSJP_1310"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1310"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="113" mass="11880" checksum="D23657E6D15A2915" modified="2017-06-07" version="1">MTVLSSRQKAFEDGPGWCGLHSPIPVPEERGPKLFYVGGFASQSESAGVVLKVGGTVPTSVFPRGLPTSYRCDGTTGFDVASIMGQVGNILDNLGLFAKVLSIALVSNKKDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3B1</accession>
    <name>A0A1W1I3B1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome bd ubiquinol oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NSJP_1151</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1151"/>
    <dbReference type="EnsemblBacteria" id="SLM47323">
        <property type="protein sequence ID" value="SLM47323"/>
        <property type="gene ID" value="NSJP_1151"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1151"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM47323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="432" mass="46351" checksum="BBE8F22A6217F2C2" modified="2017-06-07" version="1">MTDLLAARSQMAVSLGFHIIFAALGIAMPLMISIAEWRWLRTGDEGYLSLAKRWSKGTAILFAVGAVSGTVLSFELGLLWPAFMKLSGPMIGPLFALEGFAFFTEAIFLGIYLYGWSLISPVKHFIAGLMVAASGAASAVFVIAVNAWMNEPIGFTKSGEHLTELEPLAVLAQPLARHETIHMLLAAFAATGLLVAGLHAMWLLRDNRSLFHRRALGIAVAMGGAAAVLQLASGHLISLTVADRQPTKLAAMEAHFATAAGADFLLGGLADNETASVRYAVTIPKGLSLLVHGDPSAEVTGLDRVPKADWPPVAVVHLAFQVMVLCGLVMAGLALWSAWRWRRSGGLERDTWLLRGLCVAAPAGFIAIEAGWVVTEVGRQPWIIDQVMRTSEAVTPMPGLWIPFATFSLLYLVLGAVVAWAMWRHVAATEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3D4</accession>
    <name>A0A1W1I3D4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Small-conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mscS</name>
        <name evidence="8" type="ORF">NSJP_1340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47512">
        <property type="protein sequence ID" value="SLM47512"/>
        <property type="gene ID" value="NSJP_1340"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1340"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="262" mass="28307" checksum="3EAE2123A9C235FC" modified="2017-06-07" version="1">MVVMESLTQYAVRYGLHAIVAVGIFAVGVMVARWAGNLAKRQLERHTLEPPVRLLLVRVVRIIVLLFTTVIALEALGVPIAPLIAGIGVAGVGIGLALQGVLSNVMAGLSIIFTKPYRVGEHISLLGVHGDVVMIDIFSTVLMHSDRSRVIIPNRKIIGEILHNFGTIRQMTLTVNIAYTADVDRALAITREILQRHPKILKDPAPEVGVSVLGQPAVTISIQPWTAVVDYGSTQGEVNKIVMERFRAAQIDFAPSAPAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3J5</accession>
    <name>A0A1W1I3J5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47564">
        <property type="protein sequence ID" value="SLM47564"/>
        <property type="gene ID" value="NSJP_1392"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1392"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012551619" evidence="2">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="62" mass="6467" checksum="7A9F7A04FBC0692C" modified="2017-06-07" version="1">MRKLMAQAGSTAFVLLAAAAPVLANAPAGDGPPDYSGITGMYYVLIGIVLAYGVYDTFLRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3K7</accession>
    <name>A0A1W1I3K7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47586">
        <property type="protein sequence ID" value="SLM47586"/>
        <property type="gene ID" value="NSJP_1414"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1414"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35024">
        <property type="entry name" value="PTHR35024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="161" mass="16782" checksum="5353B2A2E46E68EC" modified="2017-06-07" version="1">MWGQDKQDGKRQTDVNQDTEEVQGESATVKEGLEDISAFVGKGVDFKGTISYNGTVRIDGSLEGEIRTDGTLLIGEDAIIQAKITAGTIVCKGKITGDVVARERVKLRAPAIVNGSVKTPVLSMEDGVQFNGGLEMGQGTQGATVHTLTGSSASGTKRVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3U7</accession>
    <name>A0A1W1I3U7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional chorismate mutase/prephenate dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Chorismate mutase-prephenate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">p-protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">pheA</name>
        <name evidence="22" type="ORF">NSJP_1473</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1473"/>
    <dbReference type="EnsemblBacteria" id="SLM47645">
        <property type="protein sequence ID" value="SLM47645"/>
        <property type="gene ID" value="NSJP_1473"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1473"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010957">
        <property type="entry name" value="G/b/e-P-prot_chorismate_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01807">
        <property type="entry name" value="CM_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00857">
        <property type="entry name" value="PREPHENATE_DEHYDR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 22" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14 22" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="19">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Prephenate dehydratase" evidence="20">
        <location>
            <begin position="91"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="21">
        <location>
            <begin position="278"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="18">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="SLM47645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="358" mass="39994" checksum="9367B776E5EBB6C8" modified="2017-06-07" version="1">MSGDLSEHRKEIDRIDDEILRLLNVRSKSVIEIGRLKKQQDADANLHTPAREAAIIERLVAQNTGPFPSEGIRPVYREIMSASLSLEGPQKVAYLGPRATFTHMACMQKFGSSAQYIPVHSIKEVFSEVERGRANFGVVPIENTTEGVVNHTLDMFIDSNLLIYGEVLQEVSHHLLSKSGVPEEIKKISSHPHAIAQCRNWLETHMPHVPVSEVASTARAAELCLEDASVAAIASQLAAELYGLKVIKSRIEDNLNNFTRFLVLSQKAPERTGKDKTSLMLSIKDKVGALYDLLRPFASHGLSMTKIESRPSRRKAWEYIFFVDIEGHIEEDRVKKAVEDITGRCLFMKVLGSYPAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3V4</accession>
    <name>A0A1W1I3V4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47682">
        <property type="protein sequence ID" value="SLM47682"/>
        <property type="gene ID" value="NSJP_1510"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1510"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="62" mass="6446" checksum="6D08AC5376EBCA16" modified="2017-06-07" version="1">MQVGEARIFLPPRVFSSPPAYNGAHPKVFPVKIATIQGRIVLAIVLVGAIPLSPIAGTALSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I453</accession>
    <name>A0A1W1I453_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diaminopimelate epimerase</fullName>
            <shortName evidence="3">DAP epimerase</shortName>
            <ecNumber evidence="3">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">dapF</name>
        <name evidence="4" type="ORF">NSJP_1614</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1614"/>
    <dbReference type="EnsemblBacteria" id="SLM47786">
        <property type="protein sequence ID" value="SLM47786"/>
        <property type="gene ID" value="NSJP_1614"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1614"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="74"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="217"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="227"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="3">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="3">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="294" mass="31392" checksum="FA67DA9EB59B5924" modified="2017-06-07" version="1">MKNGFFRGHGLGNDYLVMDPKELTFSLTPASIKRICDRNWGLGSDGILAIVPTKRADFGLRIFNPDGSEAEKSGNGLRIFSRYLHATGRTKKTRFTVDTKGGLVSIALHLDRHGDAASATVEMGRATFDPAALPCTLRVDELLREPIDAAGRSLRFTGVSVGNPHCVVLKPSGESWSREDLLALGPALENHAIFPKRTNVQLAVPTGPAELFILIWERGAGETQASGSSSCAAASAAVRLGLVRSPVTVKMPGGALTIEVAQDFSLTMKGPVAEVARGTLSASFLRELRAKRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4B9</accession>
    <name>A0A1W1I4B9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GMP synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1547"/>
    <dbReference type="EnsemblBacteria" id="SLM47719">
        <property type="protein sequence ID" value="SLM47719"/>
        <property type="gene ID" value="NSJP_1547"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1547"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="PTHR42695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="226" mass="24651" checksum="1137107501406626" modified="2017-06-07" version="1">MRAVCLQHVPFEGPGVFETSLRRRRVLLERHLVPQDGLPDDSGDLLIVMGGPMSANDSDPWIAKETAFIRKALLAGNPVIGVCLGSQFMAKALGAVVRPGKALEIGMTPVRLTPEATSDPVFSGLPNSFDVFEWHGEIFELPENCMPLAASDIALQAFRYGDRAYGLLFHPEMERAGIDQLCRECAVDLARTGMTAQQITEAAWPHLPALQRFADSLVGALIPCER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4I4</accession>
    <name>A0A1W1I4I4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YggT family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1744"/>
    <dbReference type="EnsemblBacteria" id="SLM47916">
        <property type="protein sequence ID" value="SLM47916"/>
        <property type="gene ID" value="NSJP_1744"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1744"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33219">
        <property type="entry name" value="PTHR33219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="YGGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="98" mass="11120" checksum="09AD53DF3ADA0555" modified="2017-06-07" version="1">MFVGGNILQAVATVLDTVLWLYMWVIIARALISWVNPDPWNPIVQFLTRATEPVLAPIRRWVGWRMGIDLSPIIAILAITFLQLALVQTLRDIAVRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Q4</accession>
    <name>A0A1W1I4Q4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase subunit E</fullName>
            <ecNumber evidence="7">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nuoE</name>
        <name evidence="7" type="ORF">NSJP_1631</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1631"/>
    <dbReference type="EnsemblBacteria" id="SLM47803">
        <property type="protein sequence ID" value="SLM47803"/>
        <property type="gene ID" value="NSJP_1631"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1631"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="176" mass="19579" checksum="42396A40058F0FE4" modified="2017-06-07" version="1">MLREKYKEEIEQILSRYPVKRSALIPLLYLAQREAGYVTEAAMTEIAGILRLTPPQVYETATFYTMLNIKKVGKHHIQVCKSLMCALVGSDTVIGWIKAKLGIVPGETTADGMFTLSAVECLAACGTGPMMQINEDYYERLTEEKVDRILADLRTTGSSPLKSGPFMWPEATETIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4T5</accession>
    <name>A0A1W1I4T5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47833">
        <property type="protein sequence ID" value="SLM47833"/>
        <property type="gene ID" value="NSJP_1661"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1661"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="103" mass="11163" checksum="E1DC4F2D77FA5090" modified="2017-06-07" version="1">MFTRLKKVLLLGLIVMLGVQLTGFTCLDEWEIGSTPDLVRIADLSPSPDESFSDDGCPCHIVFQSASLSTPEIMAPLADDVIVSATLYVPTFIVVLFHPPLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Y9</accession>
    <name>A0A1W1I4Y9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase C14 caspase catalytic subunit p20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1902"/>
    <dbReference type="EnsemblBacteria" id="SLM48074">
        <property type="protein sequence ID" value="SLM48074"/>
        <property type="gene ID" value="NSJP_1902"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1902"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="330" mass="36513" checksum="A00B20AAF179E2AF" modified="2017-06-07" version="1">MTSRIAVIVGIDLYEHYKRLYGCVNDANSVKSVLERHDDGSLNFECKLLTGSSQTNPITKFQLRDSLSQLFMANVDYALFYFAGHGDITATDTYLLTSDSRRSDDGISLTEILQMANDAAKKIRSRNRAIVLDCCYSGSAGTPPVTGELALLSQGLTILTASTAEQYSTEQDGRGLFTSLFVDALTGSAASITGHITFGSIYAHVDQSLGKLGQRPVFKTNVHEFVPIRTVRAPIALADLKRIAEFFPSDEYPFPLNPSFEPEVKGRGPGMPPPDPRNTEKFRILQAYNRINLVVPVDAPHMWHAAMEYKSCKLTPLGMHYRRLVQNGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I533</accession>
    <name>A0A1W1I533_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1956"/>
    <dbReference type="EnsemblBacteria" id="SLM48128">
        <property type="protein sequence ID" value="SLM48128"/>
        <property type="gene ID" value="NSJP_1956"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1956"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="239" mass="26796" checksum="07C8D6AA0DF1A0DF" modified="2017-06-07" version="1">MMSSNSVLRLLVMMVLWLVSGTGCTNREFSRTPRTGTEQLLLSHALERSVSAFEALSPPPAKAAVEVMGYAGTRQVLEPTLLSNSPMINSNIAPTSGPESTELNPPMMRPLGSELLMMRGFVEGRLAELGYAVVDRRDDADLWVRVMVLALGTDQGQNFFGMPAIQSTVIPFSTPALTLYAAQRQIAYVRYRLQIYDSRTRQWFIPGRWYEGSAYYNQYTVFFFINFRGTDMVEVPALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5A0</accession>
    <name>A0A1W1I5A0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1998"/>
    <dbReference type="EnsemblBacteria" id="SLM48170">
        <property type="protein sequence ID" value="SLM48170"/>
        <property type="gene ID" value="NSJP_1998"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1998"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018699">
        <property type="entry name" value="DUF2203"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09969">
        <property type="entry name" value="DUF2203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016498">
        <property type="entry name" value="UCP016498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="137" mass="15546" checksum="43C7363FD1AA67E8" modified="2017-06-07" version="1">MSQDDEQEHHDRLFTLAEANRLIPQLNSRLSSVKQARETLVRTKEDIRKASAQAEYGGGSTVGALYITSLQQVSANIKAIHELGVVVKDLDMGLCDFPHLRDGRIVFLCWKMGEQEIRWWHETTSGYKDRCPLESSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5A8</accession>
    <name>A0A1W1I5A8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48111">
        <property type="protein sequence ID" value="SLM48111"/>
        <property type="gene ID" value="NSJP_1939"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1939"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="116" mass="13088" checksum="BC9A395CB4D06510" modified="2017-06-07" version="1">MIGCPLCAGALAFRLEGHGHVQLCCTVGHTFSPSDAYKAKEEELERTQWSVIVLLKHLQMLAAIMREHDDLERGMRPSLAEREIQIKQHIQSYERLIHDTKPAQSRPPHAEPPAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5D5</accession>
    <name>A0A1W1I5D5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metal-dependent carboxypeptidase</fullName>
            <ecNumber evidence="1">3.4.17.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of a C-terminal amino acid with broad specificity, except for -Pro.</text>
            <dbReference type="EC" id="3.4.17.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M32 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.19" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48224">
        <property type="protein sequence ID" value="SLM48224"/>
        <property type="gene ID" value="NSJP_2052"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2052"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001333">
        <property type="entry name" value="Peptidase_M32_Taq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34217">
        <property type="entry name" value="PTHR34217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02074">
        <property type="entry name" value="Peptidase_M32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006615">
        <property type="entry name" value="Zn_crbxpep_Taq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00998">
        <property type="entry name" value="CRBOXYPTASET"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="510" mass="58528" checksum="A5FAB9BFBF422254" modified="2017-06-07" version="1">MKTLATLENLIDRLREIQRINSAASVLSWDQETNMPAGGGTARAEQIATLQGIAHKEFVEDETEKLLGAAVDLTTGYPLDQDGELWDESAQSLLREVWRDFNRARKLPSDFVVKLSRECSLAQQVWAEAREGNAFVDFLPNLETVLNLKREEAQYLGYAGSPYDALLDYYEPGTTIAGLRPLFAQLKARLVPLLRKIQNSPVQIDDSILFHAYDTARQLEFGRLVLIAMGYDFEKGRLDLSAHPFTTSFHPTDVRVTTRVHEHDVTSCLFSCIHEGGHGLYDQGLDPTHYGTPLGDSVSLGIHESQSRMWENCVGRSKAFWRFFYPVLQQTFHHQLRSIDLDHFYAAVNRVKPSYIRVEADELTYNLHIMVRFEIEQELIEGRVKAQELPELWNQKMKEYLGIVPPTDSQGVLQDVHWSLGAFGYFPTYTLGNLYAVQFYDQARMEIPHLEDEIAAGQLLILRQWLGQKIHRWGRMFTPERLAQRVTGVSLTPEPYLQYIERKYGELYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5E3</accession>
    <name>A0A1W1I5E3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48222">
        <property type="protein sequence ID" value="SLM48222"/>
        <property type="gene ID" value="NSJP_2050"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2050"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="117" mass="13653" checksum="CE5D0DFEC6D0DE55" modified="2017-06-07" version="1">MKSLKPLPEHLQFTQEAELLKLHIAEEAMGLRALQYEQQQSTVYCNLMGLTHDIYSLSAAKPATTIDSGRRVVNCNPLDQAHDFVFNTRSVEVCPLWHQERARKKWMRSRNTWRDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5F3</accession>
    <name>A0A1W1I5F3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DprA_WH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smf</name>
        <name evidence="3" type="ORF">NSJP_2033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2033"/>
    <dbReference type="EnsemblBacteria" id="SLM48205">
        <property type="protein sequence ID" value="SLM48205"/>
        <property type="gene ID" value="NSJP_2033"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2033"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041614">
        <property type="entry name" value="DprA_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17782">
        <property type="entry name" value="DprA_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DprA_WH" evidence="2">
        <location>
            <begin position="320"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="378" mass="40444" checksum="DB8A99FB5FAB0837" modified="2017-06-07" version="1">MQSANATNWSLLEPWLRLRAINGLGDATILSLLQVFPTPEVVLKAGFDELIERGCSRRLADAIKKGPSKSACRLIDTELSELRKTLYTVWTVLDPSYPARLRMIPDPPPLLYVSGALLEEDAVAVAVVGARRATAGGCLFTEELARDLAAAGVSVVSGLARGIDAAAHRGALSGGGRTIAVLGCGIDRTYPSEHARLRCQIEEQGAVVTEVPIGTAPEPHNFPRRNRIISGLSLGVVVTEAALDSGSLITAQLACEQGREVFAVPGSIKADTGRGTNALIKQGAALVECADDVVRVLTPQIDKPMRKNLQRSRFDPAGHGPLDGQERLVYEALSHEPRTVDEVAELIHEPVAIVTATLLSLELNRQARQLGGQRFVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5F6</accession>
    <name>A0A1W1I5F6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2058"/>
    <dbReference type="EnsemblBacteria" id="SLM48230">
        <property type="protein sequence ID" value="SLM48230"/>
        <property type="gene ID" value="NSJP_2058"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2058"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="23"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="143" mass="15754" checksum="B68B777E0CDAD71D" modified="2017-06-07" version="1">MVVNIDALSLQACRVTPTSLSRRILVIDGDDDVRGILHDRLSALGFQVTVESDGNAGLSRLTVDQHTNPFHGLLVELFLPGLNGSAVLREVRARFPTIPVIVMADSLHVADLRQAMNAGAKEYIVKPFDSELFRRKCLSVFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5G2</accession>
    <name>A0A1W1I5G2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mu-like prophage FluMu protein com (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48215">
        <property type="protein sequence ID" value="SLM48215"/>
        <property type="gene ID" value="NSJP_2043"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2043"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="60" mass="6550" checksum="62F3618F679E3545" modified="2017-06-07" version="1">MNNVSSSACSVQEARCECGQLIAKVLEKGLELKCKRCKRIVIIPFTAIVGWSDLSPKPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5H3</accession>
    <name>A0A1W1I5H3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">purM</name>
        <name evidence="14" type="ORF">NSJP_2074</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2074"/>
    <dbReference type="EnsemblBacteria" id="SLM48246">
        <property type="protein sequence ID" value="SLM48246"/>
        <property type="gene ID" value="NSJP_2074"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2074"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="12">
        <location>
            <begin position="52"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="13">
        <location>
            <begin position="168"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM48246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="340" mass="36421" checksum="C50373D413C686BC" modified="2017-06-07" version="1">MKYRVNIDVANKTKAGFGKLLDNRDPRLLNKVGAFSSLFLFDVKRFTEPVLVLKTEEPGSKQVLAFAHDRIESVCQDMINHLINDCIVMGAEPLAVQDLIVCGQLEKTIATRIVAACAAACEAQNCVLTGGETTEQPDIVPAGTYILGSSIVGVVERSRIIDGSLIAPGDVVIALSSSGPHTNGYTLIRDLLNRDPALAKQDVAGTSFLDAVLEPHRCYYGSLKDLFPLKLISGLAHITGGGIRENLDRILPHTVDASINLALYRPAPIFGAIRAASQVSDHEMLRAFNLGVGMALVCGRAHEAEVLRHLRAQGQEAYAIGEIVPGTGKVECRGLVAYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5R7</accession>
    <name>A0A1W1I5R7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">prfA</name>
        <name evidence="8" type="ORF">NSJP_2001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2001"/>
    <dbReference type="EnsemblBacteria" id="SLM48173">
        <property type="protein sequence ID" value="SLM48173"/>
        <property type="gene ID" value="NSJP_2001"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2001"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCRF" evidence="7">
        <location>
            <begin position="68"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="360" mass="40079" checksum="F3437250EBD82897" modified="2017-06-07" version="1">MEAALLKRWESLASRYDELTTQLTDPSVIGQPPLLIKLNRERTELEPVAQLFQRHRDLFKQSEDISHMLADSTIGAEFRTLAVEESARLDEAMVALQAQVMEHLTPRDPRDDKSLFLEIRAGTGGDEAALFAGDLFRMYVKFAERHKLKVEIVEASETGKGGYKTVVALIEGKGGYGLFKYESGVHRVQRVPVTEAAGRIHTSTVTVAVMPEVDDVDVQIDPKDLRIDTFCSSGAGGQSVNTTYSAVRITHLPTGVVVSCQDERSQLKNRTKAMRTLRARIVEAEREKQEAEIAQNRKAQVGTGDRSEKIRTYNFPQNRVTDHRVGVTLHKLEHVLAGDMSELVEALRSQRDQAAVAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I625</accession>
    <name>A0A1W1I625_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2285"/>
    <dbReference type="EnsemblBacteria" id="SLM48457">
        <property type="protein sequence ID" value="SLM48457"/>
        <property type="gene ID" value="NSJP_2285"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2285"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="200" mass="22114" checksum="90A8A099315AD06C" modified="2017-06-07" version="1">MGMSGLRSRSLRLRTSVLDQPPSPFLKKCLGSIVLAKPSLWLDVPCGAGRNALLLRELGCKIVCIDNADSALQAITEAESLLGRRSGQPSQGELIPLRHDLKRDPWPFPPKTFAGIINAHFVCPFLFERFLVSLKPGGYLLCETYGGHGMNYVGLPQKGSWKALLQDRMDWITYREHSVGPPDQQAVTVKFLGKKRTSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I634</accession>
    <name>A0A1W1I634_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48454">
        <property type="protein sequence ID" value="SLM48454"/>
        <property type="gene ID" value="NSJP_2282"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2282"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="39"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="174" mass="19344" checksum="2542965D53B4E353" modified="2017-06-07" version="1">MHSIVRPGSGTGSDAGVIGSSTSQGDVEPPPVSTGRRLRVLLVDDNERDRYLLKVLLEEQEEIEVVGEASNAEEAQILAEREQPDIILMDIRLPRATGIEATRQINKRLPEVTIIGVSSLYTPHDYNAMITAGAVAFVRKEDAVEALYKTIHHSTRRYRRDRPINTGRTTQRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6B3</accession>
    <name>A0A1W1I6B3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Type IV pilus biogenesis protein PilO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2375"/>
    <dbReference type="EnsemblBacteria" id="SLM48547">
        <property type="protein sequence ID" value="SLM48547"/>
        <property type="gene ID" value="NSJP_2375"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2375"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043683">
        <property type="term" value="P:type IV pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043107">
        <property type="term" value="P:type IV pilus-dependent motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007445">
        <property type="entry name" value="PilO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04350">
        <property type="entry name" value="PilO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="207" mass="22604" checksum="2BFE621ED99793DF" modified="2017-06-07" version="1">MTLPAINLEVLRTVPLAQKIGLLVLTLAGIVVGFYYYIVEPKTTEIAGLQSEISKLDGDIQTLSIKVKHLDELIAASKQLEIELAKKKERLPPEEEAVMLLKQVSDLAIRLGLDVKLWRPSVKSEDPSKLFVRMPVNVEVAGGYHTAALFFDRINSLPRIVTVSGVKMGSPKSDKGRVVTQTVFDLIAYAAPQESKTVAAVPATQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6E7</accession>
    <name>A0A1W1I6E7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rplX</name>
        <name evidence="6" type="ORF">NSJP_2349</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="3">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2349"/>
    <dbReference type="EnsemblBacteria" id="SLM48521">
        <property type="protein sequence ID" value="SLM48521"/>
        <property type="gene ID" value="NSJP_2349"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2349"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="109" mass="12133" checksum="F87D938D1D30649A" modified="2017-06-07" version="1">MEALQKVRIRKGDTVVVIAGRDRGKSGKVLSVDRTAGRVVVEKLNMIKRHTKPNQKVKQGGILEREAPLAISNVMFLCPVTQKPTRLGVRVQADGKRVRFSKKSKDTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6F8</accession>
    <name>A0A1W1I6F8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_2287</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2287"/>
    <dbReference type="EnsemblBacteria" id="SLM48459">
        <property type="protein sequence ID" value="SLM48459"/>
        <property type="gene ID" value="NSJP_2287"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2287"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024023">
        <property type="entry name" value="rSAM_paired_HxsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01384">
        <property type="entry name" value="thioether_bond_formation_requi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03978">
        <property type="entry name" value="rSAM_paired_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="97"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="485" mass="55482" checksum="8FD4D109C5BF1ABC" modified="2017-06-07" version="1">MSHFQGIEHYQPSTSSYRLLPFRFSHLQNEQYVLTNLAGEYWTTERSTLLNLLAHRLQQTDPAYCELRARHFLMDASTAIAPQLLSIKLRTRNHRLAEFTGLHLFVVTLRCEHSCPYCQVSRRSQDTLRYDMGPDAGRAALALALRSPSTHIKIEFQGGEPLLNFPLIQTLVLEAKERNRVLKKELAFVIATNLALITEEMLTFCRDHSILISTSLDGPRDLHNQNRPRPGGDSYERTIRGITLARESLGHDQVSALMTTTEASLSHAIAIIDEYVAQGFKGIFLRPLSPYGFAIKTRSYQAYNTDRWLTFFKEGLEHIIELNRRGHDFSEYYASTILKKMLTSDDPGYVDLMSPAGIGIGAVVYNYDGHVYASDESRMLAEMGKEEFKLGHVLTDTYKDIFTSSKLLDSLEDSFAYSNPMCHDCAFEPYCGADPVYHYAVHGDYVGRKPESEFCKRNMEIFRYLILKMEKDSFVNQLFTKWANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6G2</accession>
    <name>A0A1W1I6G2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Iron dicitrate transmembrane sensor FecR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2425"/>
    <dbReference type="EnsemblBacteria" id="SLM48597">
        <property type="protein sequence ID" value="SLM48597"/>
        <property type="gene ID" value="NSJP_2425"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2425"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032623">
        <property type="entry name" value="FecR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16220">
        <property type="entry name" value="DUF4880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="DUF4880" evidence="2">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="1">
        <location>
            <begin position="122"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="328" mass="36202" checksum="66EC3DBA2CDAFA02" modified="2017-06-07" version="1">MSNEQASSSPRPEEARIVEEAIDWFGRLRAGNVSAADRAAFDQWCQQDPLHARAFRRINAGWDHPILKEAAALAASTEFPAVPLKSQPPTWWRPALAAAAVVAALVVLAQASWDLWTRMQADYYTTVGERRTIQLPDQSTVTLNTQTAIVVAYEGAVRTIHLLKGQAFFKVAADRQRPFIVEYAGMATKAVGTEFVVHAQPRGLDVTVVEGLVQVADEKHSWPDIALAAGNEVHVEQGRADPPHAIDPRMATAWLRGHLMVTDARLGDVLDEVRRYYPGTIIILNPTLNQIHVTGTYHLDQPAALLTTLSRTLPFHMVTVADRLAVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6H9</accession>
    <name>A0A1W1I6H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chlorite dismutase</fullName>
            <ecNumber evidence="4">1.13.11.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.13.11.49" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2444"/>
    <dbReference type="EnsemblBacteria" id="SLM48616">
        <property type="protein sequence ID" value="SLM48616"/>
        <property type="gene ID" value="NSJP_2444"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2444"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050587">
        <property type="term" value="F:chlorite O2-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010644">
        <property type="entry name" value="ChdC/CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36843">
        <property type="entry name" value="PTHR36843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06778">
        <property type="entry name" value="Chlor_dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="266" mass="29734" checksum="02257FF4A7DE8FF2" modified="2017-06-07" version="1">MSRSRCAGLYAIVLCVLLGGWVSASYAAADRDKLLSEPGIYGTFAAFGLTEEWGRLDAPAKIAHLTALKGVVEQHREKVAIDLYLLRGLSDHADVLFRIHAADLRDSQKFLVDLHASPMGRYLKGAGVLNGMSKKANYVPGFPDQMKADLKTASEPGPVPYAIVIPIRKSAEWWALDQEKRAVMMKEHTEAALPYHKTVKRKLYHSSGLDDLDFITYFETSNLEDFHNLILSLEKVKEFQYTRRFGHPTLLGTSKSLDQLIETLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6L2</accession>
    <name>A0A1W1I6L2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48615">
        <property type="protein sequence ID" value="SLM48615"/>
        <property type="gene ID" value="NSJP_2443"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2443"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="73" mass="7682" checksum="79529E1AD666C7FC" modified="2017-06-07" version="1">MPPVSTRGIICGTSTKYFVGCSEARDGEGAPKESEEADESITLCRAVCHCAVCPIGRVGVGVLRRRRSGQAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6R7</accession>
    <name>A0A1W1I6R7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase superfamily enzyme, subfamily IA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2561"/>
    <dbReference type="EnsemblBacteria" id="SLM48728">
        <property type="protein sequence ID" value="SLM48728"/>
        <property type="gene ID" value="NSJP_2561"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2561"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="247" mass="28230" checksum="EA500A0A8B5BD4B7" modified="2017-06-07" version="1">MLIKGIIFDVNGTLVDIRTDEGYEEIYRILSNLLSYQGISLDPNGLKDVYFQIMKEQRTVSRERHPEFDAVGIFREIMTRYATDFTRGLSAVKLEQLPTLLAETYRAASRFRLQVYPGVDDTMAQLQAKYRLAVVSDAQTAYAIPELNAVGLFRYFDPIIISGALGCRKPHERLFTQALAAMDMQPSEVLYVGNDMYRDVYGAQRVGIKTVFFRSNQGTQEKEGVNPDYIIYAFPELLNAVRFFEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6R9</accession>
    <name>A0A1W1I6R9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48675">
        <property type="protein sequence ID" value="SLM48675"/>
        <property type="gene ID" value="NSJP_2503"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2503"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012438749" evidence="2">
        <location>
            <begin position="29"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="295" mass="31394" checksum="540E7AAB81F671AD" modified="2017-06-07" version="1">MRCVGVRLWVVLCVVVGLSLPTSATLWAADPPKPAEATTPPPEPEKRGILGDRFSLDAGLKIWVAKWQPAGFVNGINSTRTSDTTPMLGPSVTGTFRLRNEETFNALSVNFTWLQAGGFNFTPFGYNNGGSGPPIDNTTALRRDYSIVAALSIWRGFGFFAGYYNMQQRFNSTYPGAITGPAHETVYISGPLIGFFGSGTVAGPLKAYGNLAIGFYDEKSNNNPSNTVQTTAKGVQGYSSEFGLSLDGPSLKTGAGSIGSALQVGFRAQVINVNANGLANNDVTWGPTFQVIARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Y7</accession>
    <name>A0A1W1I6Y7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2610"/>
    <dbReference type="EnsemblBacteria" id="SLM48777">
        <property type="protein sequence ID" value="SLM48777"/>
        <property type="gene ID" value="NSJP_2610"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2610"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="98" mass="10666" checksum="D84E2E6A53A58D97" modified="2017-06-07" version="1">MIRVVLPAHLRNLARVEGEVTLAIEGPVTQRAVLDALEARYPMLCGTIREHGTHTRRAFVRFFACEQDWSHESPDTALPQAVATGAEPFLIVGAMAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7E6</accession>
    <name>A0A1W1I7E6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent RNA helicase HrpB</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hrpB</name>
        <name evidence="4" type="ORF">NSJP_2775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2775"/>
    <dbReference type="EnsemblBacteria" id="SLM48942">
        <property type="protein sequence ID" value="SLM48942"/>
        <property type="gene ID" value="NSJP_2775"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2775"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010225">
        <property type="entry name" value="HrpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013689">
        <property type="entry name" value="RNA_helicase_ATP-dep_HrpB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08482">
        <property type="entry name" value="HrpB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005496">
        <property type="entry name" value="ATP_hel_hrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01970">
        <property type="entry name" value="DEAH_box_HrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="196"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="841" mass="92631" checksum="A01A2893B73FDFD9" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7I9</accession>
    <name>A0A1W1I7I9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2662"/>
    <dbReference type="EnsemblBacteria" id="SLM48829">
        <property type="protein sequence ID" value="SLM48829"/>
        <property type="gene ID" value="NSJP_2662"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2662"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="268" mass="29191" checksum="BC5CE3FF717CCAEB" modified="2017-06-07" version="1">MTPPDRWFGAGRTETGYVRTTNQDAFAVLNDRMVWVVADGMGGHPAGDVAARMAVASILQAAESSLLSEHRTTDDSCRMLSEWLIAANREIHEQAQAQPGLTGMGTTIVTMTITGVPTPVVSIAHLGDSRAYLYRAGTLRQLTRDHTLIEKYLRSGLIDEAQSKIHPERHVLTQAVGIERHVTPTTTTIPLQPEDRLLLCTDGLTKMLDDREIAARLSDAEADPSRLRDALIDQALDRGGEDNVTVIVCMRVEATGGHRAIDNTVSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7L5</accession>
    <name>A0A1W1I7L5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49038">
        <property type="protein sequence ID" value="SLM49038"/>
        <property type="gene ID" value="NSJP_2871"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2871"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="283" mass="31182" checksum="D22378D45A376FC4" modified="2017-06-07" version="1">MDRYFRTMVYILALIILLSGYGSPVLAEETSPDAPFSDKLMIRGGWAYVFGATANASVAGPVLGLGAAVDFTNTLGGNSSTDAFRIDGLYRFNDRHAVGVSWYRVGLSGNKALTQDIQIGDNAVSAGATTQTGLSFNTYRLLYNYSFYRTDKAELAFSPGLYMMKTNFNFAAQGTINGVTRNTALVNEQITLPLPSVGLVANYDITKKLQFQSRFDFFYLSINSYSGSMFEFYGGLEYRLFKHFAMGAAYDRLIAGLRGDGDKGFTVNFSYNLAYVYATLYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7T8</accession>
    <name>A0A1W1I7T8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2909"/>
    <dbReference type="EnsemblBacteria" id="SLM49076">
        <property type="protein sequence ID" value="SLM49076"/>
        <property type="gene ID" value="NSJP_2909"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2909"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014004">
        <property type="entry name" value="Transpt-assoc_nodulatn_dom_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00749">
        <property type="entry name" value="BON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="56"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="137"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="216" mass="23046" checksum="D4DD3BF60BB8E4D4" modified="2017-06-07" version="1">MLGDARFLRCASCVMQWSCSAGLVVALVGTAGCVGAKYKAMLEAAQSELSPAAIAQDDLHKVHIHEAMVAEQGLSSLTLSINVFMERAYLVGHVDNREQGEAVLKTARHVQGIRSVEGYLPVTAPSADGNTMSDKTSDVSLKAQVISALAIEPKVVKSRVHVEVLDGHVVLLGVVSGEPERHHAETAAAGVEGVKAVTNWLLLPEKGYMTIRKKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7V9</accession>
    <name>A0A1W1I7V9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49096">
        <property type="protein sequence ID" value="SLM49096"/>
        <property type="gene ID" value="NSJP_2929"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2929"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="106" mass="11522" checksum="EA923A6ED0661BE0" modified="2017-06-07" version="1">MTSGEHNRITGQTQEGFNISLDAQADQVKQAWVRFGTIDPAGNHKWEASIALKGSSVSKGQKKIIASVYDDQLPAKPQDCFYQILCEVEGPHGDPVTLITEPTPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7W5</accession>
    <name>A0A1W1I7W5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49075">
        <property type="protein sequence ID" value="SLM49075"/>
        <property type="gene ID" value="NSJP_2908"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2908"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="221" mass="24308" checksum="94AC7839E1621ABF" modified="2017-06-07" version="1">MLAGCTPFHLSDMYSVSTPKPASLDASVLTAQPLMTFPAAAPAALQGYRPVVSHALSEALAASTPSFHEIPPIETLNRISSNGLVADYEEMAAGFSRSGIFDRQRLEKIGAALGVRYVLQPGLADFSEAIGDRLMLAGWRVVKMRAATLRLWMRLWDMRTGEILWEATGEATVTSELIEDTPTIPVHEIARRLWARILAEHLLGDKIKVGFQLRDEKPVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7W7</accession>
    <name>A0A1W1I7W7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tmk</name>
        <name evidence="5" type="ORF">NSJP_2940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2940"/>
    <dbReference type="EnsemblBacteria" id="SLM49107">
        <property type="protein sequence ID" value="SLM49107"/>
        <property type="gene ID" value="NSJP_2940"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2940"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="4">
        <location>
            <begin position="26"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="249" mass="28275" checksum="E60DEF3C3B2783AE" modified="2017-06-07" version="1">MGDAHYFGDGLTYLNPSDLKGKLIAIEGTDGVGRSTHIEMLQEWLEVQGYGVITTGWTRSNLMSKTIEVAKEGNIIDRWSLSLLYATDFADRLEHQIIPALRSGFIVLADRYIFTAFARDFVRSSDRKWIRDVFGFALVPDLVCYLRIDVETLVLRVIETKAMNYWESGMDLRLGADLYDSFKKYQSLLIEEFDKMAEEFKFEVVDARKSPEEIQDELRSKIQQLLTQGGLARTMTAPPVVEGAANPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Y9</accession>
    <name>A0A1W1I7Y9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48923">
        <property type="protein sequence ID" value="SLM48923"/>
        <property type="gene ID" value="NSJP_2756"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2756"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010722561" evidence="1">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="90" mass="9808" checksum="1F4A0EDE29ED72C0" modified="2017-06-07" version="1">MKRLALPAVLLLVSVSTGHAESLCRQCFDAAKQELKKCMEAAISAEDKATCHQKHDAKSTTCEEGECKLEQAAKPSLKDKPASEPLPERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I825</accession>
    <name>A0A1W1I825_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2904"/>
    <dbReference type="EnsemblBacteria" id="SLM49071">
        <property type="protein sequence ID" value="SLM49071"/>
        <property type="gene ID" value="NSJP_2904"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2904"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010621">
        <property type="entry name" value="DUF1214"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037049">
        <property type="entry name" value="DUF1214_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010679">
        <property type="entry name" value="DUF1254"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037050">
        <property type="entry name" value="DUF1254_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06742">
        <property type="entry name" value="DUF1214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06863">
        <property type="entry name" value="DUF1254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012890392" evidence="1">
        <location>
            <begin position="22"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1254" evidence="3">
        <location>
            <begin position="91"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1214" evidence="2">
        <location>
            <begin position="356"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="479" mass="53834" checksum="36FF230257C78E0C" modified="2017-06-07" version="1">MIEKLAGLSLAAILVSTSAWAEEYAFTNGFPTPKAAQRVQDEQDYQRAIQTYRFFYPTVSMEATFQGTRDAGAVDNKSAMILSGGPRHVLFTGNADTPYMGGVFNLKETGSLVIELPPGGYLGIVNDHHFGWIHDIGLPGDDAGRGGKHLILPPDYQGEVPAGYYAGRSKTHFILVGARALPPGGDMNAGLEAQRQVKIYPLSQADNPPAYEFVDRTRDKIDVTLLRWESNLKFWERLHKVLQEEPAIEEFRPMYGMLAMLGIEKDKPFQPDERMKKILLRAAKDGRAHMLAAGFASNRPDRFVWKDRQWEYSTLRWENGDFELPTGIDLEARDRWFSQAVGMSPKMVLRVEGAGSLYWLGLRDKKGNYLDGGKTYKLSIPQPVPQKLFWSVTVYDNQTRSMIQTTQDKAALRSLVELKDVPQTGVTDLYFGPKAPAGQEGRWIKTIPGKGWFVYLRLYGPVGPAFDGSWKPEDFEEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I869</accession>
    <name>A0A1W1I869_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49196">
        <property type="protein sequence ID" value="SLM49196"/>
        <property type="gene ID" value="NSJP_3029"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3029"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="155" mass="16995" checksum="AADFA31B9E04E11F" modified="2017-06-07" version="1">MIRVVHYLSIFVVSVFMMGIWVSSLVLAAPPAIEPCKIVTIAEVEQIIGKLKEAPKSGQEGEAAWCNYEFANGKDAFEIWVFPASGIDRARKLAKKPVQLKGLGDDAFMNRGMHGLDYVDIFIKKGSATVKLSLHETAGDEDKLKALAQKAVGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8B0</accession>
    <name>A0A1W1I8B0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Heavy metal efflux pump, CzcA family, Acriflavine resistance protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3090"/>
    <dbReference type="EnsemblBacteria" id="SLM49257">
        <property type="protein sequence ID" value="SLM49257"/>
        <property type="gene ID" value="NSJP_3090"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3090"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004763">
        <property type="entry name" value="CzcA/CusA/SilA/NccA/HelA/CnrA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00914">
        <property type="entry name" value="2A0601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="859"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="885"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="911"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="960"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="988"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1023" mass="112469" checksum="E74D963FAEC672E9" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8G2</accession>
    <name>A0A1W1I8G2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FecR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3044"/>
    <dbReference type="EnsemblBacteria" id="SLM49211">
        <property type="protein sequence ID" value="SLM49211"/>
        <property type="gene ID" value="NSJP_3044"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3044"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010712511" description="FecR domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="66"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="211" mass="22727" checksum="488D2B43AC1D7461" modified="2017-06-07" version="1">MMILRHVLLAVPLLALLNLTPIPQAAADNIPIGTATNAVGTLVIVRTDGVQQRLQGKGNIPLYEGDVLKTDASSQALITFSEGIEVALNEDTSFKLLSRWEKDKPTVRILRLKQGEVWAKTAGGPKRFEVETPVATASVKETEFNLKVQEDGQSILTVIEGIVQFGTPFGTCPIRTDTISYGVRGKKCTKPATSDAKAAKSWTEAVRGGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8G6</accession>
    <name>A0A1W1I8G6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49296">
        <property type="protein sequence ID" value="SLM49296"/>
        <property type="gene ID" value="NSJP_3129"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3129"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="94" mass="10481" checksum="0F14AA3609CD80B6" modified="2017-06-07" version="1">MKPVTVQNPEEILTMLADVALRGTGFVTECLLDYVLDEGFTEPIYFNASGEDPEAYFKGQSPAWAVYQVREWKRVLTVSGGPGKARRVQITETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8H4</accession>
    <name>A0A1W1I8H4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_3139</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3139"/>
    <dbReference type="EnsemblBacteria" id="SLM49306">
        <property type="protein sequence ID" value="SLM49306"/>
        <property type="gene ID" value="NSJP_3139"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3139"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="157"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="210" mass="22207" checksum="7D08BA9A266647D7" modified="2017-06-07" version="1">MAGVITELVLATRNLHKGEELTALLSSLGIRVRTLAEFPDAPEVIEDGDTCEANAVKKARTIADVTGLPAVADDTGLEVDALDGRPGVFAARYAGEHVTYEDNWRKLLKELAGVSREGRQARFLTVAALALPGGVVEVAQGTLEGIIAEEPAGTGGFGYDPVFHVPELGKTLAELSAEQKNCISHRAKAFAEIREILLSKSESSGTVRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8J6</accession>
    <name>A0A1W1I8J6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminodeoxychorismate synthase, subunit II</fullName>
            <ecNumber evidence="2">2.6.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pabA</name>
        <name evidence="2" type="ORF">NSJP_3201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.85" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3201"/>
    <dbReference type="EnsemblBacteria" id="SLM49368">
        <property type="protein sequence ID" value="SLM49368"/>
        <property type="gene ID" value="NSJP_3201"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3201"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="187" mass="20695" checksum="E3AE8ED621AC16D6" modified="2017-06-07" version="1">MLLMIDNYDSFTYNLVQYFGELGEDVRVYRNDQLTIAQIEALKPSRIVISPGPCTPKEAGISVDTIKHFAGRVPLLGVCLGHQSLAAAFGGEVVRADRLMHGKTSMVRHDGKTLFRDLPNPFEATRYHSLVVKRATLPACFDVSAETAEGEIMGLRHKSLRAEGVQFHPESILTAAGKDLLRNFLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8K1</accession>
    <name>A0A1W1I8K1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49347">
        <property type="protein sequence ID" value="SLM49347"/>
        <property type="gene ID" value="NSJP_3180"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3180"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="159" mass="17809" checksum="3F7EB85F94C3BEC3" modified="2017-06-07" version="1">MDAGTVAHPISDAVRRLGLLGCFLGPILTAAPSSAAADASVPWECSNYSEQAQARCMNAFIEQQREQIQKLEAQLRVERDAVAGLKSQVERQAATTSDLQQQLSQKPTTTLVPTPYAYTYAFPPVGVGIYLGRPWIYGPPYYYHPYWGPRFYGHWGRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8K8</accession>
    <name>A0A1W1I8K8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA repair protein RadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49330">
        <property type="protein sequence ID" value="SLM49330"/>
        <property type="gene ID" value="NSJP_3163"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3163"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="44"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="168" mass="18266" checksum="C32206EB1CE56790" modified="2017-06-07" version="1">MDGAQTPRKPKRPRTSAPTFTPYRVPRYRLTLVCESSDSVMSGPIQASLAAVAILRPCFAGLDREQFLVAGLDAKHGIIGINIVSIGSLTLSIVHPREVFKPLILMNAAAFICAHNHPSNDPTPSQEDRLLTQRLRQGADLLGITLLDHLVLGDPSYFSFADHGWPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8R7</accession>
    <name>A0A1W1I8R7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49412">
        <property type="protein sequence ID" value="SLM49412"/>
        <property type="gene ID" value="NSJP_3245"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3245"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="129" mass="15014" checksum="60F1B24302DCCD28" modified="2017-06-07" version="1">MDQESLIQIQRIIGAATESLRTDIAEAQRNTGALREELQLVADSLRTDIMESRRQTGILTEGLRHELQLVAESFQLHVSQFHAEERSHMDEQFRETRALVQLSYGQIQERVERLEHRFRTIEQHIGPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Z7</accession>
    <name>A0A1W1I8Z7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49401">
        <property type="protein sequence ID" value="SLM49401"/>
        <property type="gene ID" value="NSJP_3234"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3234"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007844">
        <property type="entry name" value="AsmA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032712">
        <property type="entry name" value="AsmA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05170">
        <property type="entry name" value="AsmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13502">
        <property type="entry name" value="AsmA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsmA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="AsmA_2" evidence="2">
        <location>
            <begin position="280"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="549" mass="58694" checksum="3C02E81C00660662" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I978</accession>
    <name>A0A1W1I978_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3324"/>
    <dbReference type="EnsemblBacteria" id="SLM49491">
        <property type="protein sequence ID" value="SLM49491"/>
        <property type="gene ID" value="NSJP_3324"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3324"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021383">
        <property type="entry name" value="DUF3015"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11220">
        <property type="entry name" value="DUF3015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013139608" evidence="1">
        <location>
            <begin position="25"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="179" mass="18915" checksum="5DAABADAD7769E00" modified="2017-06-07" version="1">MRSRTIGGLVFCLCALLHQHGAQGAAVSDNGPGCGLGKLAWMDYDGPKQIAPQVMMATTNATFGSQTFGISSGTSGCTNDGVVMKNKHINIASHAFDRLTEEMAQGNGEHLASLATLLGVPEESKPAFFALVQDRYQRVVGTDEVTPAVLLKVLQDAMAERPALARLPFVGDVSEDPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9A0</accession>
    <name>A0A1W1I9A0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49576">
        <property type="protein sequence ID" value="SLM49576"/>
        <property type="gene ID" value="NSJP_3409"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3409"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012009155" evidence="2">
        <location>
            <begin position="30"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="296" mass="32222" checksum="7F2D51616F4E7D01" modified="2017-06-07" version="1">MLRATGRINLLVILLCSLYIGLSPSASFAAEDHGTIARSQDYFPDTIGSHWEYRGQITEGPVQTIEHKSFQNVSSVTGTKSLKGVTVTTFHDTNPGNHGVSDSFYRRDTVGIVYYGSEPGTPLEKQLVPYQIVRFPMKVAASFSQFDKKELDFGTDMDQDGVNEKADVQGSSTVVGQEAVTVPAGTFPDAVKIEARMQMTIQLSAAKKTVTGTDVMAAWFVKGVGLVKYVERQELSPLQDRGLITEIVEELESFEIKPSRASLGRGESPAQGLFADDSHGNELQQVVLTTGLRADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9C9</accession>
    <name>A0A1W1I9C9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1080 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49648">
        <property type="protein sequence ID" value="SLM49648"/>
        <property type="gene ID" value="NSJP_3481"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3481"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1080" evidence="1">
        <location>
            <begin position="146"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="317" mass="34444" checksum="904A925D9D1DF69B" modified="2017-06-07" version="1">MIRLLGIGVLGVACVIAELLSPIRVPAAPTQTSSSVDFTGRWDLTTRGANGLSSAWLEIDATTADKIQGRLVWLYGGADPIYDIIIDDRTVTFHHSGTGEHLIFTARLVDDRLEGVASGARSQVQWTGIRAPDLHASGQSDWEYPRSLMNGRDLSGWVPRSGRDPRCWRVEKEILFNESPCTDLVSELRFSDFQLHVEFQLRDGGGSGVYLRGRYEVQIGNDAGMPATSRTTGAIFGQLSPSSSEAKPLGEWQALDVTIVGRNVTVAVNGRRVISESDIPGITGAALDSHEELPGPIMLQGDHGRVAFRNILLTPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9G9</accession>
    <name>A0A1W1I9G9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase III subunit alpha</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dnaE</name>
        <name evidence="10" type="ORF">NSJP_3479</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3479"/>
    <dbReference type="EnsemblBacteria" id="SLM49646">
        <property type="protein sequence ID" value="SLM49646"/>
        <property type="gene ID" value="NSJP_3479"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3479"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="9">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM49646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1151" mass="127560" checksum="40F964EFEF6D345D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9H7</accession>
    <name>A0A1W1I9H7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3475"/>
    <dbReference type="EnsemblBacteria" id="SLM49642">
        <property type="protein sequence ID" value="SLM49642"/>
        <property type="gene ID" value="NSJP_3475"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3475"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="726" mass="74279" checksum="2ED57D8A9333EDFE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9L1</accession>
    <name>A0A1W1I9L1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HD-GYP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3519"/>
    <dbReference type="EnsemblBacteria" id="SLM49686">
        <property type="protein sequence ID" value="SLM49686"/>
        <property type="gene ID" value="NSJP_3519"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3519"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="2">
        <location>
            <begin position="46"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="704" mass="76685" checksum="4CE859871100A1B8" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA57</accession>
    <name>A0A1W1IA57_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Linear gramicidin dehydrogenase LgrE</fullName>
            <ecNumber evidence="3">1.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3771"/>
    <dbReference type="EnsemblBacteria" id="SLM49938">
        <property type="protein sequence ID" value="SLM49938"/>
        <property type="gene ID" value="NSJP_3771"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3771"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="30"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="264" mass="29459" checksum="069686D873D7DAD8" modified="2017-06-07" version="1">MTIATTGRSQSEVAREWIGLSRPAHKSRMHLIAFPYAGGGASVYRRWQNDLAHAKWLDFTVLQLPGRETRIRERPHNDLAQLLKELEWAVGAAVDRPYALFGYSMGALLAYELAVRLAESHAAPERLLVAARCPPWRNRHRPAAIPSRDALLAWVRRLGATATELLDTDLFIERFLPTLEADIRIVDGFARDVPQILPCPIDAFSSDDDAEVSIDDMRCWETAAGSGFRLHRLGGGHFFLHRSHNELIALINQILGSHASSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA83</accession>
    <name>A0A1W1IA83_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">zwf</name>
        <name evidence="10" type="ORF">NSJP_3735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3735"/>
    <dbReference type="EnsemblBacteria" id="SLM49902">
        <property type="protein sequence ID" value="SLM49902"/>
        <property type="gene ID" value="NSJP_3735"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3735"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="8">
        <location>
            <begin position="26"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="9">
        <location>
            <begin position="213"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM49902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="514" mass="58034" checksum="1D431D8BC884F7A6" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAF0</accession>
    <name>A0A1W1IAF0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Multidrug resistance protein MdtG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50027">
        <property type="protein sequence ID" value="SLM50027"/>
        <property type="gene ID" value="NSJP_3860"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3860"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="6"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM50027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="389" mass="40506" checksum="FF788FB72B016303" modified="2017-06-07" version="1">MTSARSFVLICTVGVLCFISYNMVRMPVLALFAESLGAGPERIGLIVSVSTLTGVLLKLPSGALSDIYGRTILLRIGVVAFGLPPFLYPFITDLNALTALRFAHGLATAIFAPSALATVAELYRERRGAALGTYTACTQSGALLGPFIGGYLVYTSGFPAAFVTAGVFGCAAIVLFYSLRLNVAPPRMQGRGLSAVTAEMWKGFTVVSRNKKVLITSSTDAAKMIANGALMAFLPLYGLSVGLNAGDVGLLFSVQAFTSFFSKPIMGRVSDRIGRQPLIVLGLMICAATFVCIPHVSFFPLLLVLSAGFGFGEAVVSSSSSALVADSSEFKTLGAGMGMQGTIMDIGHASGPLLAGILIAVMSYAGAFAVIAGLQLVAASAFWITMRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAK5</accession>
    <name>A0A1W1IAK5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ribE</name>
        <name evidence="4" type="ORF">NSJP_3858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3858"/>
    <dbReference type="EnsemblBacteria" id="SLM50025">
        <property type="protein sequence ID" value="SLM50025"/>
        <property type="gene ID" value="NSJP_3858"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3858"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="23"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="23"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="119"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="119"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="239" mass="25829" checksum="7A8A70F9032AE6F2" modified="2017-06-07" version="1">MARRVLARRGARVRRGHFQYPVMFTGIVEEMGAIRSVDKTLAGTRMTILATAVMSDLKVGDSVSVNGACLTVAERHEAWFAVEVSPETLSVTTLGRLAAGAPVNLERAMKLNERIGGHLVAGHVDGIGRVRSRRSDANAIVVTIDLPPEVLRYCVMKGSITVDGVSLTINEVADHAVSVAIIPHTAKVTTLGLKQVDDPVNLESDLIGKYVERLLQDRSQLSKPTPAIDTDYLKKKGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAL7</accession>
    <name>A0A1W1IAL7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Iron dicitrate transmembrane sensor FecR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3930"/>
    <dbReference type="EnsemblBacteria" id="SLM50097">
        <property type="protein sequence ID" value="SLM50097"/>
        <property type="gene ID" value="NSJP_3930"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3930"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032623">
        <property type="entry name" value="FecR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16220">
        <property type="entry name" value="DUF4880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="DUF4880" evidence="2">
        <location>
            <begin position="19"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="1">
        <location>
            <begin position="117"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="323" mass="35581" checksum="724B150A16ACECA2" modified="2017-06-07" version="1">MDQPSTPLPSDQNQDRIADEAIAWFSRLRMSSATAQDLEAFERWCDAHPAHREVYERVSAMWDNPGLSVAASRTATFDGSRKTATAQWRPLAAIAASVVILILVILQWDLVTRAQADYYTGVGEQTTVRLPDQSVMTLNTSTAIAVQYDPAARKIHLLRGEASFKVTPDPSRPFVVEHQGIHTRAVGTEFIVRQLSRGALVTVSEGKVAVSNPTASWPVIPLEAGREARVDRGTGGEPYDVDLAIATAWLHGRLVVTSARLGDVLDEVRRYHSGTVMVWNRDIENMRITGTYNLNDPSKLLGTLSKTLSFRTITVAGRVTVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAM3</accession>
    <name>A0A1W1IAM3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ECF subfamily RNA polymerase sigma-24 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50098">
        <property type="protein sequence ID" value="SLM50098"/>
        <property type="gene ID" value="NSJP_3931"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3931"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="174" mass="19774" checksum="95D0B17142BEA2DD" modified="2017-06-07" version="1">MSLTYLQLEQLFASQREALSRRLMRLVRSKELAADLIQETFVRLMGMSETQTVSNPRALLFRTASNLAIDHLRKQKVESRHISESVPLEAAEQVASQAPTPERELWGKQQLERVQAAIDALPASVRETFLLHRFHGYAYHEIAAIQGVSESTVDKRMNRALKDCWAALQSQNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAQ4</accession>
    <name>A0A1W1IAQ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Penicillin amidase</fullName>
            <ecNumber evidence="6">3.5.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.11" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3905"/>
    <dbReference type="EnsemblBacteria" id="SLM50072">
        <property type="protein sequence ID" value="SLM50072"/>
        <property type="gene ID" value="NSJP_3905"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3905"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008953">
        <property type="term" value="F:penicillin amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014395">
        <property type="entry name" value="Pen/GL7ACA/AHL_acylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001227">
        <property type="entry name" value="Pen_acylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM50072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="807" mass="87555" checksum="251F2ABE754B3F74" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAV3</accession>
    <name>A0A1W1IAV3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-arabinose 5-phosphate isomerase</fullName>
            <ecNumber evidence="8">5.3.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">kdsD</name>
        <name evidence="8" type="ORF">NSJP_3977</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SIS family. GutQ/KpsF subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.13" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3977"/>
    <dbReference type="EnsemblBacteria" id="SLM50144">
        <property type="protein sequence ID" value="SLM50144"/>
        <property type="gene ID" value="NSJP_3977"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3977"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019146">
        <property type="term" value="F:arabinose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004800">
        <property type="entry name" value="KdsD/KpsF-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004692">
        <property type="entry name" value="KdsD_KpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00393">
        <property type="entry name" value="kpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="38"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="207"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="274"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004692-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR004692-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM50144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="326" mass="34292" checksum="480E2999CE0600BC" modified="2017-06-07" version="1">MSAKGTGGSLLEGKRVLGIEARAVQALIDRLDDRFVQAVDLLYGCKGKVVVSGMGKSGLVGQKIAATMASTGTPAFFVHPAEGLHGDLGMVGRQDVVVAISNSGEAQELIQLLPYLERMGIPVVAMTGRPDSTLAKHSDVVLDVSVSEEACPLGLAPTASTTATLALGDALALALLQKRGFKEEDYAQFHPGGALGRRLLVRVKDLMHAGSDVPTVEESVTGTTAMLEMTAKKLGMTTVVDRTGALSGVITDGDLRRFIQRGGDFLKATAGELASRNPKSIRPDDLAAKAVEIMERHSITTLIVTEGPRKIVGVIHLHDLLKNGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAX8</accession>
    <name>A0A1W1IAX8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50152">
        <property type="protein sequence ID" value="SLM50152"/>
        <property type="gene ID" value="NSJP_3985"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3985"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="406" mass="44645" checksum="982E3A2DD62C341C" modified="2017-06-07" version="1">MLIFLQIILFNIILLTVPGHAKAEQPDQISERWAALFSGQESSDRATHSAASLSQTNLTPTFFAMPVVSTRLRDLSPETDQPRTRGLQAATTWLKGKMTTEAELANNQGGPAWLQGRIPGNTYDQMSDRMVRVGMTGTAGIMRYGMTYRSAGQAFLNGPDTAIREVWGEWKYGGTTLRSTFGQQWNNVAGDAARSRLEQTYGRVGVGWSKPAWPSLTLTYARNSLSSTLNPIGIAPQRNHNHTLEAALAYNSARWNATLASSYIIGSDLLRNGAESNVKMQLFAASFHPLNTLTITPTLIYREEQQEWSRVRTDSPSASLALQYKQSQRLLITAMGNYAGIRSSDRLIDLENLGGKGVLAWDLQQSAQWMTLISLEAGYTRQTNHATPAADMEDISGVVKVVLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAZ0</accession>
    <name>A0A1W1IAZ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50166">
        <property type="protein sequence ID" value="SLM50166"/>
        <property type="gene ID" value="NSJP_3999"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3999"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="159" mass="17521" checksum="23E219BC4EA0F2D5" modified="2017-06-07" version="1">MADPGDSDFVYGHILVSIEPADFLYRHLHGLCGHAPQIIGGETLPPRSRRKVQHRLIHQSGRLDADPCAPIQPDPGSQEDRLSLDILAPFAFVEGMPGGVRRKNAPAVRTIKHEVTGELADYPPACLFNTFKERQITGEPNMTGSLNRNKGRISHLTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBG1</accession>
    <name>A0A1W1IBG1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="10">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="10">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">gatB</name>
        <name evidence="12" type="ORF">NSJP_4084</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4084"/>
    <dbReference type="EnsemblBacteria" id="SLM50251">
        <property type="protein sequence ID" value="SLM50251"/>
        <property type="gene ID" value="NSJP_4084"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4084"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="11">
        <location>
            <begin position="327"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM50251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="478" mass="52739" checksum="BC70A1408D3F2E43" modified="2017-06-07" version="1">MTYEVVIGVEVHAQLRTKSKMFCGCGTTFGLSPNSQTCPVCLGLPGSLPVINKAAVEMAVRAGLALNCTVARANRFARKNYFYPDLPKGYQISQYEAPICEQGWIDIATGDGRKRIRIRRAHLEEDAGKSVHESASAGSRVDLNRAGTPLLEIVTEPDMRSSEEVVAYLKGLRDILMYLEICDGNMEEGSFRCEPNLSIRPLGQQEFGTKVELKNINSFKYVKDAIEYEVKRQAKVLQDGGAIRQETRLWNLDRGETAVMRSKEEAHDYRYFPDPDLVPLKLDPQWIEDFRDSVPELPAARAGRFVNQYGLPEYDAGLLTASKAMADYFEACVGLFPHPKTVSNWVMGELTRELNTAGVDVDSSAVSPERLVGLLAMVDRGTVSLKVAREIFPELYQSGKSAEDIVRDKGLTQVSDEGVLESLVTEVLAKNPGQVAQFKEGKHQVLGFLVGQVMKASGGKANPGKVNELLKSKIGDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBW6</accession>
    <name>A0A1W1IBW6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50263">
        <property type="protein sequence ID" value="SLM50263"/>
        <property type="gene ID" value="NSJP_4096"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4096"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010740868" evidence="1">
        <location>
            <begin position="24"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="285" mass="30819" checksum="457FAEA673CFEDDF" modified="2017-06-07" version="1">MTKPAGILTLLLMALLIPSQGWSIPAEEEPPPDPHLNEPKATTIVVRVVAHGAMVIGREVGGARVTIADAATKQILATGIQQGEAGDQNQIMRTPRTMEEPIYSSRPSAAFTTTLELNRPTFVEISAEGPLAHPASMQRTTETVLLVPGQDHTNDGIVLHLYGYLVQVERPKPGDSLIAKEDAKLRASVRTLSGTLVRPHGDWDSRKITIYGEVLIGNRIVERLQMFYSGESSSFEAPFFVPAVKDAPDGIMLRVVATDLSTGNSGMGTATYPVITERLNPALRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZY3</accession>
    <name>A0A1W1HZY3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46277">
        <property type="protein sequence ID" value="SLM46277"/>
        <property type="gene ID" value="NSJP_0105"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0105"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="153" mass="16934" checksum="0AB5A1CB90A8C6F6" modified="2017-06-07" version="1">MKARTKALHPWRAFFLCAGLWGGLMGFLVVSQVEAVDQSPMTEDEAAKLGEEFGVVVGEVDEEIQKELKLQRPQGVAVFEVIGNSRADYAGIKVRSVIKEIDKTEIKNMPEFGRAIKKAMKECNFTVGTYEPADPGDPVGWGVNFHFVGCKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I017</accession>
    <name>A0A1W1I017_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Type IV pilus biogenesis/stability protein PilW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0176"/>
    <dbReference type="EnsemblBacteria" id="SLM46348">
        <property type="protein sequence ID" value="SLM46348"/>
        <property type="gene ID" value="NSJP_0176"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0176"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="229" mass="25227" checksum="B8FB0E6DCA65A5C3" modified="2017-06-07" version="1">MTTSLSRTAAGRRSSYCAAVAVIGLGLVTGCATSEESKQKSKGYYQEGLASLDRDRQKAYVSFQKAVQLNPDNKEARYGLGHILAVQGKFAQAEQEFRAAIKIDEEYSEAHTYLGQVLISQDRWAEAIPEFRKALTNPLYSTPDLARFHLGRALAHEGDLQGAMEALEDALTVNPPNVPPAQSNLELGRIYYKMGFDRRAVETLTKVTLIDKNGEYGTAAKEILARLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I025</accession>
    <name>A0A1W1I025_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidoglycan-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">pal</name>
        <name evidence="10" type="ORF">NSJP_0183</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the Pal lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0183"/>
    <dbReference type="EnsemblBacteria" id="SLM46355">
        <property type="protein sequence ID" value="SLM46355"/>
        <property type="gene ID" value="NSJP_0183"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0183"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02204">
        <property type="entry name" value="Pal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039001">
        <property type="entry name" value="Pal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012076990" description="Peptidoglycan-associated protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="9">
        <location>
            <begin position="135"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM46355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="252" mass="25804" checksum="9E545ABB2128049C" modified="2017-06-07" version="1">MRTMSKRFPIALLAIAMLVGPAGCAKKGVQSAGDQTAQQSAAKSGAAGTGSGSSSSMKSGVGSFPDTSMQSGSGGLKGLDKNPSEERLGGGPGGSSGNGPGGQGSQGGPGSGTLLAKADPSESAGHQLDEIRAEQAASAAAGLRDVFFGYDSWTISEEGRQSLGRDADWLKSNPGAMLKVEGHCDERGTAAYNLVLGEKRAKAVRNYLVELGIGANRLSVVSYGKERPFCNDHAEACYQQNRRGHLVVRTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I063</accession>
    <name>A0A1W1I063_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative peptidase M50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NSJP_0190</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0190"/>
    <dbReference type="EnsemblBacteria" id="SLM46362">
        <property type="protein sequence ID" value="SLM46362"/>
        <property type="gene ID" value="NSJP_0190"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0190"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="S2P-M50-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="15">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SLM46362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="248" mass="26101" checksum="D086B762C139AB93" modified="2017-06-07" version="1">MNGIGHILYQISYMGLPLLFAMVLHEYAHGWMADKCGDPTAKLQGRLTLNPLAHIDPFGTILMPLLCLMLPGGFLLGWAKPVPIDPRNMSRPRRDMALVAAAGPGMNLALAVVSALALTAILTLDPGLSIRGESRGADAPDAGAGSMFLLPIAVMAFYSVLINVFLGLFNLIPIPPLDGGRILVSLLPPQPAMALARLEPYGMLILVGLLVFDKELRVIHTISSVFATGLSGTLLSTALGLSTGGSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0E3</accession>
    <name>A0A1W1I0E3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein TolQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tolQ</name>
        <name evidence="9" type="ORF">NSJP_0187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0187"/>
    <dbReference type="EnsemblBacteria" id="SLM46359">
        <property type="protein sequence ID" value="SLM46359"/>
        <property type="gene ID" value="NSJP_0187"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0187"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="104"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="232" mass="24499" checksum="3A980BE402C2E3A6" modified="2017-06-07" version="1">MFQAGLTGAVGTLGTVSKVVLLLLFVFSVISWAIIFAKWRAFRSADRGDKQFMNLLAKSHDLNELYRQVRHLPASPSAAVFEGVMDRLAGARAEGQDGSAPIDRHLVERSAAHLSQSQLSKLESALPFLATTGNITPFVGLLGTVMGIIDAFREIGSQGTASIAAVAPGVSEALVATAAGLFTAIPAVIAYNYFLTRIRRTAFRLDTVAIELLGAVPSPAPKSAPVPVGAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0S0</accession>
    <name>A0A1W1I0S0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46600">
        <property type="protein sequence ID" value="SLM46600"/>
        <property type="gene ID" value="NSJP_0428"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0428"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="137" mass="15256" checksum="1234C561340ED69F" modified="2017-06-07" version="1">MAPTDLPTPQSDDQPSRHDNARRREQDSGSDTQLHVVGVMIGTALIFIGFLNVFLSISGGFEINVVPLLIYFGGIAVWANAAIEAPMFRYGVIACALALAFAFFHYGEVLFWHKQVVFWATVVIVMYFMFNEPKKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0S1</accession>
    <name>A0A1W1I0S1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0424"/>
    <dbReference type="EnsemblBacteria" id="SLM46596">
        <property type="protein sequence ID" value="SLM46596"/>
        <property type="gene ID" value="NSJP_0424"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0424"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="84" mass="9646" checksum="2C601E5E49777478" modified="2017-06-07" version="1">MALTLYHVDWCPECDVVRRKLAEAGLAYEGVIVPDVRPFRKQVYEVSGQYYVPVLKDGDTVLTETDEILAYIERKAEADRLAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0X3</accession>
    <name>A0A1W1I0X3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug efflux system, subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mdtC</name>
        <name evidence="2" type="ORF">NSJP_0321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0321"/>
    <dbReference type="EnsemblBacteria" id="SLM46493">
        <property type="protein sequence ID" value="SLM46493"/>
        <property type="gene ID" value="NSJP_0321"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0321"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="858"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="908"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="953"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1034" mass="112301" checksum="85A350AC1C105003" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Y0</accession>
    <name>A0A1W1I0Y0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Zn-dependent peptidase, M16 family</fullName>
            <ecNumber evidence="4">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0488</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.24.-" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0488"/>
    <dbReference type="EnsemblBacteria" id="SLM46660">
        <property type="protein sequence ID" value="SLM46660"/>
        <property type="gene ID" value="NSJP_0488"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0488"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012867952" evidence="1">
        <location>
            <begin position="26"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="42"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="193"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="445" mass="48878" checksum="B0EEBD38B2F0CC2C" modified="2017-06-07" version="1">MGIKHWIGLGLWSCLLVLSASPLPAAEIVPTRFIAANGMTVVVLEQHFLPIVEIHSLIKTGSAQDPPEKAGLANLTASLLDEGTTTRTSKQIAEQIDFVGGSLEVKASEDFTTASVRVLKKDAELGFTLLADMLQHPAFNKQEFERIRTQILGEMASDNDDPGHVAMKAFNQLVFHGHPYRWPLNGTEETLGKITVADVAAFYAKEYIPGQVILTVVGDVTVDQVMALAQTHFGGWKKSPAPARNVRKPGALEKKTVQLIEKDLTQSSIVLGHGGINRTNPDFYAVTVMNYILGAGGFSSRLMDSIRDKQGLAYGIMSHFDARLMPGSFWISLQTRSETTNQAITGVLAELKGIRDAPVSDQELAEAKSFLVGSFPLRLDSTAKLAQVLAQVEFYGLGFEYFSQYPKWIERVTKEDVQRVAKHYLDPQRYALVVVGNLAKSRVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Y3</accession>
    <name>A0A1W1I0Y3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase_M23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0472</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0472"/>
    <dbReference type="EnsemblBacteria" id="SLM46644">
        <property type="protein sequence ID" value="SLM46644"/>
        <property type="gene ID" value="NSJP_0472"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0472"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="245"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="344" mass="37214" checksum="3DD58743F80DFA22" modified="2017-06-07" version="1">MTLMGQTTGAENSDSYTVVIFRGSTAKPLRFSFPRKFVRKLLIVCGIFIIADLFVLSHYVIRTGEVWELSAFRSEAMSARQQTAAFSNAIDDLKKRLSSMKEVNQRLRVMLGIETPKTGDTVNGRGGEDGPLPDGNAVSPSASLKGDAALQLSESDKNGASTQPRNIADQSELDEHELLAVVKQGIDWLSREASAQERALQELSLAAEQKSSRWAATPSIWPVRGWVTSGFGPRVSPFTEKPAWHDGLDIGAAANAPVQAPAQGRVTTVGFDSKLGNLVRLDHGFGIETLYGHLAKALVKEGQRVKRGDVVGLVGSTGLATGPHLHYMVKVNGQTFDPTKYILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Z3</accession>
    <name>A0A1W1I0Z3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46654">
        <property type="protein sequence ID" value="SLM46654"/>
        <property type="gene ID" value="NSJP_0482"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0482"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="132" mass="14302" checksum="8BAF70FEB51C84A1" modified="2017-06-07" version="1">MALTVGRHQGLGVLTEANFEPVEHSGIRIDAAGMDVRIAMLAELKKSRAVRSLVPFLANVLAILARIIEFIVSVGTVSNGVRLIPLPLRVRTSRPVRKASRYGGTARGFPLEERSVRINPAGRSSSRGSYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I129</accession>
    <name>A0A1W1I129_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46684">
        <property type="protein sequence ID" value="SLM46684"/>
        <property type="gene ID" value="NSJP_0512"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0512"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="217" mass="23997" checksum="425411AAE47C09C5" modified="2017-06-07" version="1">MAVRGWGDALKLTACAYMVLAGAIPAWSIDVKLSMEDAQKALEAGRAPMDKANSPEEVKKVLQQASMATRVGADPEKDSCGASAVLRTKRYRLEAFGRQEASESKKRKTEIRMPEEFIKKVVDMPNMEVEVQLCGDDEYFAEGALIEMQQGTKRIKPIDIGKAERGRKNEGSGPAYRSRFTAVFSYESFDPNAVSVFVVNFQDGKEAKINADFSKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I177</accession>
    <name>A0A1W1I177_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46593">
        <property type="protein sequence ID" value="SLM46593"/>
        <property type="gene ID" value="NSJP_0421"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0421"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="43" mass="4692" checksum="B6D4912883F912D3" modified="2017-06-07" version="1">MLLGTTCGTERTDSAEEPVCAVDAAIEELLDFSFILALFPWTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1A0</accession>
    <name>A0A1W1I1A0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46767">
        <property type="protein sequence ID" value="SLM46767"/>
        <property type="gene ID" value="NSJP_0594"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0594"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="87" mass="9614" checksum="D07D67FED1ACFBB9" modified="2017-06-07" version="1">MIDEGRLFQRGGSLLEHGCLFGGVPLNLFAVMRFEPRESFMERLDVEHCDGERTNTTMGTAGPTWDRSEQGGFSPLKPAVGLALESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1F3</accession>
    <name>A0A1W1I1F3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46814">
        <property type="protein sequence ID" value="SLM46814"/>
        <property type="gene ID" value="NSJP_0642"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0642"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021738">
        <property type="entry name" value="DUF3309"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11752">
        <property type="entry name" value="DUF3309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="53" mass="5777" checksum="875E99122DA853EF" modified="2017-06-07" version="1">MNNILLVILILLLLGALPTWPYSANWGYYPSGLLGVVLLIVVVMLLTGRLPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1I3</accession>
    <name>A0A1W1I1I3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methylisocitrate lyase</fullName>
            <ecNumber evidence="3">4.1.3.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prpB</name>
        <name evidence="4" type="ORF">NSJP_0557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.30" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0557"/>
    <dbReference type="EnsemblBacteria" id="SLM46729">
        <property type="protein sequence ID" value="SLM46729"/>
        <property type="gene ID" value="NSJP_0557"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0557"/>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012695">
        <property type="entry name" value="PrpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02317">
        <property type="entry name" value="prpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="307" mass="33945" checksum="768A0CEFD3102283" modified="2017-06-07" version="1">MKAMRDERGTRRARRFRELLDKQTLILPGAFNALTAMQIERAGFHALYVSGAGMSAARGLPDIGLLSLTEAAYDSATITKAVAIPAIVDADTGFGPPLAVMRTVKEFEAAGLAGMQIEDQEMPKKCGHLPGKRVVPTDDMAGKIRAAADARQDPDFFIIARTDARAIEGLESAVRRARIYIDAGADAIFPEALESADEFRTFARHLAKEGGKAPLVANMTEFGKTPYLSVAEFEELGYRLVLFPVTALRMATQAVDEMLSELKTRGSQRGLLERMYTRTKLYDLLRYADYEQWDRRVHSTEDGHANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1M2</accession>
    <name>A0A1W1I1M2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0736"/>
    <dbReference type="EnsemblBacteria" id="SLM46908">
        <property type="protein sequence ID" value="SLM46908"/>
        <property type="gene ID" value="NSJP_0736"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0736"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="141" mass="15318" checksum="A68D88888B727D3E" modified="2017-06-07" version="1">MAILPLVLMGAIGAFHVADKIITLGTMSSRALAMAQARIEAKRSVRWERILMDDLNHDGMFESVMHDDGQNGDLVGGDGVYSATAEKEGVSLMWTVTPSRTGRLSGAGYVVIESRAIYETNQGHREIKLIAIRANPVYVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1P8</accession>
    <name>A0A1W1I1P8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">rbfA</name>
        <name evidence="2" type="ORF">NSJP_0764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0764"/>
    <dbReference type="EnsemblBacteria" id="SLM46936">
        <property type="protein sequence ID" value="SLM46936"/>
        <property type="gene ID" value="NSJP_0764"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0764"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="132" mass="14800" checksum="3D18B518CD6DBE00" modified="2017-06-07" version="1">MTRSKTEYSRANRVADQIRMEVADILMRKIKDPRVKSVTVTDAELTSDLRIARVFVTVLGSEEETTEVFTGLARVAGFVRGELGRRLTLRYLPEIIFVKDVSGPRGDRVLRLLDELHGGTQLEHDSPTTGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1S3</accession>
    <name>A0A1W1I1S3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46958">
        <property type="protein sequence ID" value="SLM46958"/>
        <property type="gene ID" value="NSJP_0786"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0786"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012348142" evidence="1">
        <location>
            <begin position="37"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="151" mass="16584" checksum="99136CEBF0CE1D33" modified="2017-06-07" version="1">MTMMCPKSIGAKCGFNLLLLCLLLGSVLLCYASAEAGPPAAYTTEHPITIDATVLDPPSWWQVPGVTPSIYNSDPESMDAYKTTDKQTLALRPGKYKFVSFTFDFPFSVNLEGKVEFASSLDQCVGGRGTQTLLVRCKRTYPYGGEPDYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1V3</accession>
    <name>A0A1W1I1V3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0818"/>
    <dbReference type="EnsemblBacteria" id="SLM46990">
        <property type="protein sequence ID" value="SLM46990"/>
        <property type="gene ID" value="NSJP_0818"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0818"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012596662" description="FGE-sulfatase domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="3">
        <location>
            <begin position="51"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="312" mass="34913" checksum="BC54C93C8582BBF3" modified="2017-06-07" version="1">MRVGAVSCAVLMMAGGLAGSVLALDVADVTRTWTPEGKALAAERIKLPAHDEMMRVPAGPFLMGSNKRVDKNAYQPEFPQRQVHLDAYDIDKFEVTTVQFLKFVLAENRDPLIDWQYDGGNFQETMVNHPVMHVTWFDAEAYCKWAGKRLPTEAEWEKAARGEDGRIYPWGNEMAGLSRANFGRTGLSGPVRDRPERLILYPPIISVDKYDNAVSPYGAFQMGGNVAEWVADWYDKDYYKTAPDRNPKGPDTGTQRGFRGGGWIDSTPSVRVSQRNGTEPKTAMNWLGFRCARDVKDANQMSEGKPQQTGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1V5</accession>
    <name>A0A1W1I1V5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46961">
        <property type="protein sequence ID" value="SLM46961"/>
        <property type="gene ID" value="NSJP_0789"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0789"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="423" mass="45997" checksum="B44E514D71A07A8F" modified="2017-06-07" version="1">MPVENNFQHDELSRKSPGDRLGTAELTTGPMPDSPAWAEAMAEHGTRLARAGVRTVLFLHGSMHGTDLFGMQRLDQVGGLKRGYSRGVSGLDALLAAMRQDSNGIPPLPGGLTPPFYDDVPTRQALDHQLKDAGNFTEADVTLYAKAVNRSIADPISCRRLVWASEHHHLGRAVATIRLLDSLRAFALQEHWTSGQRVLIQAHGQAGLVLALASNFLCPSPVTGRAALLGILSSYAAQAQLEDLASTLARLAPHIESGSLLNGAALDVVTFGTPVRYGWDPSGLGALLHIVNHRNLRTDGKSWLSKMELPQITMEMPIAWGGDYVQELAVAGSDALPSSELATAANKAIWEMVEPYDGFERWLECARRAVRFPTEGRCLSVDYKDSTGSTNPRDHYYGHAVYTRREAMLFNTAQIVKLLYGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1W6</accession>
    <name>A0A1W1I1W6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0799"/>
    <dbReference type="EnsemblBacteria" id="SLM46971">
        <property type="protein sequence ID" value="SLM46971"/>
        <property type="gene ID" value="NSJP_0799"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0799"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032836">
        <property type="entry name" value="DsrE2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13686">
        <property type="entry name" value="DrsE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="176" mass="18936" checksum="F4ABB82E0F67D3DB" modified="2017-06-07" version="1">MTTTQLDPAVNLSDLQASKPDRVTIVLLSGDLDRAMAAFIIATGAAAMGMQVTIFFTFWGLNAIRRKGATSSAKDWLRRMFGLLNKGGAETLPLSRFHFGGIGTGMMHRVMKQSRMPGVPELMATAMDLGVRFIACTTTMGLMGITKDTLIDGVDQFAGVTTYLAEAKHGSVNLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1X5</accession>
    <name>A0A1W1I1X5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Uroporphyrinogen III synthase HemD (Modular protein)</fullName>
            <ecNumber evidence="3">4.2.1.75</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.75" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0809"/>
    <dbReference type="EnsemblBacteria" id="SLM46981">
        <property type="protein sequence ID" value="SLM46981"/>
        <property type="gene ID" value="NSJP_0809"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0809"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40082">
        <property type="entry name" value="PTHR40082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEM4" evidence="2">
        <location>
            <begin position="161"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="422" mass="46238" checksum="8677FFE3179E1067" modified="2017-06-07" version="1">MTRSDQAERLRTKSRQLAVGVLKLLGALPRTPDILALEPSIVKAVTSLAAGCRALVRSASQTEEAVGRLDATNEADDCLFWLDLLVATAPEHEAAIRPWLEELADLTALLSTDVKLEETFSVEPSPDRQSASDPVEHGTQEGEATGRPLRMLSFESRMAKDMARLIEHAGGTPLVAPALREISIPLQENGAVFRFGVKLMLHQIDIVILLTGVGTRALLETLQIRYPLAQLIEALKHTMIVTRGPKPLAALKHVGLEANLTVPEPNTWQDVVATLDYYRPVQGLRVAVQEYGVSNPDLINDLKTRGAEVFVVPLYRWAMPIDTTPMTGAIEDVLRGAIDVLLVTNAAQIDHVMQLVERDGKTEAFRIACRRLVIASIGPTASERLRHYDLPVDMEPSHPKMGILVKEAAALAPTLLQRKRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I263</accession>
    <name>A0A1W1I263_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Peptidylprolyl isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0928"/>
    <dbReference type="EnsemblBacteria" id="SLM47100">
        <property type="protein sequence ID" value="SLM47100"/>
        <property type="gene ID" value="NSJP_0928"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0928"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13145">
        <property type="entry name" value="Rotamase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="3">
        <location>
            <begin position="173"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="339" mass="38388" checksum="697ACC59762CC262" modified="2017-06-07" version="1">MIHPTSLTIWLVAGAACGALVWLPDRPPAQAAHVEDRIIAIVNTDLIMLSEMNRELKPEKDRIQRQYRGTELTRQLSIAQSMTLTAMIERRLQLQEAKARSVEVTDQEVKQAVHQLKQQGEKLDEKDPANMKAVREQLTLLKVVDREVRSGVMVADPEMKRYYNEHRDRFSLPEEYTLSQILIRPRSPDDLSDATEKARTVVKLLKQGESFEDLALRYSDGANASRGGRIGLVRQGELLPAIERGVATLVPGGISDVIQSPEGLHIVRLDDKKPKQFRPYDEVRLEIQSLVYQQKSEDMFQDWLADLKNKSYIEIKFESAPSAPSTGDPSPRPLSTNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2H8</accession>
    <name>A0A1W1I2H8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47023">
        <property type="protein sequence ID" value="SLM47023"/>
        <property type="gene ID" value="NSJP_0851"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0851"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="185" mass="19961" checksum="74B7816D83B041BB" modified="2017-06-07" version="1">MQSGPALRNSWSSAGCLATLCHGQTASREPMTLWLERSDSFSRVADRLTGIVAWLSAGWMFLSACGDYLSIGGADSRLGGWPFTLPAEAFRESLRELLEWYSVTQDSNAVSRLHSLRPGYAREPKSTSSLSPVRSSAPCMLLRLVYGPKALAGHESLYGKVAMGVPSNPDVCVTQSQCGINAEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2L5</accession>
    <name>A0A1W1I2L5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium-transporting ATPase KdpC subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP phosphohydrolase [potassium-transporting] C chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-binding and translocating subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-translocating ATPase C chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">kdpC</name>
        <name evidence="12" type="ORF">NSJP_0891</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the KdpC family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0891"/>
    <dbReference type="EnsemblBacteria" id="SLM47063">
        <property type="protein sequence ID" value="SLM47063"/>
        <property type="gene ID" value="NSJP_0891"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0891"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00276">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="PTHR30042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001296">
        <property type="entry name" value="K_ATPase_KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00681">
        <property type="entry name" value="kdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM47063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="190" mass="20515" checksum="C614856CAF007DD1" modified="2017-06-07" version="1">MRVHIRPALTLLFIMTVLTGLVYPAAVTGLAQLAFPGQANGSLIVRHGRVIGSELIGQPFHKPEYFWSRPSATLPFPYNAAASSGSNLGPTNPVLIETVKTRVDALRAADPGNDAPIPVDLVTASGSGLDPHISPAAARYQVRRVARVRGLGEETVNALVSRYTEERQFGLLGERRVNVLKLNMAIDQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2P9</accession>
    <name>A0A1W1I2P9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Secretion protein HlyD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1106"/>
    <dbReference type="EnsemblBacteria" id="SLM47278">
        <property type="protein sequence ID" value="SLM47278"/>
        <property type="gene ID" value="NSJP_1106"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1106"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="2">
        <location>
            <begin position="39"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="367" mass="39942" checksum="2611AB35351232DC" modified="2017-06-07" version="1">MKISRTYLVLVLGAALVGVSGYVLARFIGQGSLPDGLIQANGRIEGDHVTVASKFPGRIVELHAREGAKVTKGAVLIRLDDVQMRAKVDQAARLVDTESAQVEAAHTQLAVLNLEVPLSIEAASAKVASANAAVAKARAVEYEARQDVGRMRALIREQAVSQQQLDQAEARWKVAVTEISVAKASLDHATKELGQAELGWQRIRAKEAEVAALERQRDQADAALAEARSILQDLTIVAPADGTVTTRMVDVGEVVAGGAPLLELVDLDKLYLQVYVPEVQIGKIGLDLPARIYTDAFPDQPFEATVRYIASKAEFTPKEVQTPDERVKLIYAVRLYVKDNPEHRLTPGLPADAIIRWMDNAAWVRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2T4</accession>
    <name>A0A1W1I2T4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1017"/>
    <dbReference type="EnsemblBacteria" id="SLM47189">
        <property type="protein sequence ID" value="SLM47189"/>
        <property type="gene ID" value="NSJP_1017"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1017"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="140" mass="15651" checksum="35F50074C9CF29DD" modified="2017-06-07" version="1">MSYERRANSPLAEMSRVLLRLHKALLDDERLAYERVHGRIASNGAFLQLVLGDPWFAWLRPLSQLMVRVDELDESREPAAPDDIATLVASARTLLTPSEEGEGFGRHYYDALQRSPDVGLAHAEVRALLARPASGKECIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Z1</accession>
    <name>A0A1W1I2Z1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47249">
        <property type="protein sequence ID" value="SLM47249"/>
        <property type="gene ID" value="NSJP_1077"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1077"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="170" mass="18610" checksum="9F2D688DEF62DE4E" modified="2017-06-07" version="1">MATRGLLVLWGLLLGASLVLAEGTPVAKIVPSGDFLEFEHDGRSEPERLPLYRTGGIRYFSAGIGLEERSASYPGFSLKLIFTAGGKPFLSGVAVTITPARGGKPIVIPREHVEGPWLFVDLSPGLYEVTASYGNDLQRFKKVKVEPGKQRVIHLRWPHDHGISIHTPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I334</accession>
    <name>A0A1W1I334_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1071"/>
    <dbReference type="EnsemblBacteria" id="SLM47243">
        <property type="protein sequence ID" value="SLM47243"/>
        <property type="gene ID" value="NSJP_1071"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1071"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="121"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="363" mass="42133" checksum="3967EB938C0C9638" modified="2017-06-07" version="1">MMMPRLKTHNLVSYLRNCFGPKTILLSYGPIGQESVQGKDKRYGYGSPVRIRFRTGETVRSAVISTLTPGPFGHEHMADRAQAILWDYESYGRLPRHVKALDVGAFTAGQELFSVSRAREFFVLNEWVEGTGYQTDLERLAKGYGLRPLDRQRMLALARYLARIHTQKRRDPDLYRRRLRELIGHGECIMGLTDSYPKRLGFITEELLREIEDSCNRWRWRLRGKTHRLSQVHGDFHPYNVLFRTRTDFSVLDRSRGEWGEPADDVTAMTMNYLLSSLIRYGRLQGPFEILFRGFWDAYLKTSGDQDVMSVAAPFFAFRGLVVASPVWYPNLTIAVRRSIFHFITNVLGATRFEPDRVNEYCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3F0</accession>
    <name>A0A1W1I3F0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47409">
        <property type="protein sequence ID" value="SLM47409"/>
        <property type="gene ID" value="NSJP_1237"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1237"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="130" mass="15203" checksum="6F35F56B88BB85AE" modified="2017-06-07" version="1">MGAYYMGKRASGDNRPSRTWHEGIGDQTQEHFEVRHGKAFQPVLVLIARIWATKSGPHTVEIFRDHLLEGFVRDLTLQSLKGELDLYLKKDERNICQYLKHHCTTASNVYSYFHWAFIKRACVRSKPIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I402</accession>
    <name>A0A1W1I402_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Ribonuclease Z</fullName>
            <ecNumber evidence="2">3.1.26.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.26.11" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1564"/>
    <dbReference type="EnsemblBacteria" id="SLM47736">
        <property type="protein sequence ID" value="SLM47736"/>
        <property type="gene ID" value="NSJP_1564"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1564"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="47"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="251" mass="27763" checksum="B8E0A7AEF5C32849" modified="2017-06-07" version="1">MQLTILGSGTNLHPTRAAAGYLVRTDQTLLLDFGPRTLTNLLKTGLNRHRITHILFSHFHADHFSDFITFFFDAVIYMKYGGGWRPDLTLIGPRGSKRLLGTIMATFPSFSAPPFRVFFKEVSDRSFMIGETRIAPRVMTHVPDLHCVGYRVEYRGKTVAYSGDTQYCGNLLRLCDGADVAVLDCSFPANKPGAAHLHAGQCGLAAKEAGIGRLVLSHFYPIAERYDVRAQAGEEFTGPITIGKDLLTIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I440</accession>
    <name>A0A1W1I440_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47787">
        <property type="protein sequence ID" value="SLM47787"/>
        <property type="gene ID" value="NSJP_1615"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1615"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="58" mass="5811" checksum="5FC83FBD42B6BDE4" modified="2017-06-07" version="1">MKSPPASFPRRSGTHGGLALAQPVPVPVSDGNGTVADRRGDSLLAAALAGRPETAPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I445</accession>
    <name>A0A1W1I445_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47721">
        <property type="protein sequence ID" value="SLM47721"/>
        <property type="gene ID" value="NSJP_1549"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1549"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="315" mass="35157" checksum="24DC1112B650DC28" modified="2017-06-07" version="1">MIADSLRRGRCDRSLSSVPGVVRLLRWSFACGCDTIFVVKQSIKQVDDLRWLLGHTGGFRGGYVTDVQMSKRRLFDEGSAREVLADTSVTVVVRYRLRQMERVAKLTMTGVTDFSIFEQEGADCSSLSTIQAECTAGKLRFWFDPQGELYVVCDEAQFEEVAVPFRDETFRDQPAQWTFQSPVAEWPTVEWLLKGLEESGLPCTWKQSKASTRRQGTVQWEGDLLPAVEPERPDDGGVHAMLYGPVDGPGFGIVLHVAGTQSPAACRILSSTADLLVRHFCGRCLVGNTIIPGGDWLNWKSLEHRRLTGPEPLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I459</accession>
    <name>A0A1W1I459_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit J</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nuoJ</name>
        <name evidence="2" type="ORF">NSJP_1626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1626"/>
    <dbReference type="EnsemblBacteria" id="SLM47798">
        <property type="protein sequence ID" value="SLM47798"/>
        <property type="gene ID" value="NSJP_1626"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1626"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="172" mass="18547" checksum="B8B802CAB91755A2" modified="2017-06-07" version="1">MESLFFFYFALVIALTSILVVALHNPIYSALSLLIMFFHVAGLYVTLHAEFLAAVQIIVYAGAILVLYLFVVMLLNLKHDERYHHQWPIAAAVGGILVIEGTVLALLKGQAGPRAGSAETAAVEGLGNTEALGDVLYTSYLFPFEVASLILLVAMIGAIILAKRDLPESAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4B6</accession>
    <name>A0A1W1I4B6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47867">
        <property type="protein sequence ID" value="SLM47867"/>
        <property type="gene ID" value="NSJP_1695"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1695"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="124" mass="13671" checksum="9AAA27FD5895AB55" modified="2017-06-07" version="1">MAEVFHSGAFLQQCWSVHPLCIAVKRMGADRTLILSCSSCRSVHHLALGSVTVRASVVSADPQDPERPGDPDEGEVRLTECLRAHAAALSLRDMDVFKDLVLIRCAECRRHYAVAVTAFETHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4C5</accession>
    <name>A0A1W1I4C5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1680"/>
    <dbReference type="EnsemblBacteria" id="SLM47852">
        <property type="protein sequence ID" value="SLM47852"/>
        <property type="gene ID" value="NSJP_1680"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1680"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007354">
        <property type="entry name" value="CruF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39419">
        <property type="entry name" value="PTHR39419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04240">
        <property type="entry name" value="Caroten_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="276" mass="30919" checksum="F7B228A19D37458F" modified="2017-06-07" version="1">MDIAVLFFNTILLRPYVFVFLAGFLISAIQLLGWPRAWRLWLISWLTAFVCEFSSTRTGIPFGWYFYTGSTAGQELYFSNIPFMDSISFSFLLYAAYCTALCVVLPCDRTDSASRLQPLRFDLAVRSGWQALLLTSLLFAAIDMVIDPVALRGDRWFLGKLYYYAEDGAHFGVPLSNYAGWMVVGLISLAIYFPLDRRLPPLAVRPGVATTHRVLLGVGLYYGVLLFNLSVTFWIGETTLGFSGALMFLPLTIVLVLRLAAPRKQPVAGNEPTEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4C6</accession>
    <name>A0A1W1I4C6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Farnesyl diphosphate synthase</fullName>
            <ecNumber evidence="3">2.5.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.10" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1682"/>
    <dbReference type="EnsemblBacteria" id="SLM47854">
        <property type="protein sequence ID" value="SLM47854"/>
        <property type="gene ID" value="NSJP_1682"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1682"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:geranyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="296" mass="32356" checksum="1A516DDD2BFCB595" modified="2017-06-07" version="1">MNIKDYLEHKQVEVDRFLDQVTPAATLPPTTLHESMRYSLMAGGKRIRPILAIAAAEAVETNPPGLMAVACSLEFIHTYSLIHDDLPSMDNDDFRRGKPTNHKVYGDAMAILAGDALLTMAFDLCSRPDLMKGCDPTRQVRLIQELAYGSGHAGMVGGQVFDIQAENRDIDLAALQNIHKHKTGMLIRAAVRMGAIAAGATDRQLNDMTGYAEDIGLAFQVADDVLNVTGTREELGKNPNTDAERGKKTYPTFYGVDGAKKFADECVARAIGRLSSFGQSADPLREIARYITSRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4U7</accession>
    <name>A0A1W1I4U7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_1848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48020">
        <property type="protein sequence ID" value="SLM48020"/>
        <property type="gene ID" value="NSJP_1848"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1848"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012190345" evidence="5">
        <location>
            <begin position="21"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="56"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="171" mass="18583" checksum="6A60C18EE3B74AD8" modified="2017-06-07" version="1">MNQMKIGQAGILFALGLVMAACGGEGGGEGPVVPPPPAPAEYADKHMPAGWWTDAGKLEEGRKLFIGETNPDVNCASCHGKDGKPVKAGARDFRNGERMKLYSDSVWFWRISEGVPNTKMKAWKSKLSDEDRWKLVLFERSFGLAGKSWDADKKQWADSGEIKVAAADAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4W5</accession>
    <name>A0A1W1I4W5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1886"/>
    <dbReference type="EnsemblBacteria" id="SLM48058">
        <property type="protein sequence ID" value="SLM48058"/>
        <property type="gene ID" value="NSJP_1886"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1886"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="237" mass="26556" checksum="761469F32C277BA3" modified="2017-06-07" version="1">MPVCWETHSSPEMGDRPQAIVNRQVLSDSDLLIAVFWTRLGSPTGEAQSGTVEEIEEHRRAGKPAMIYFSSAPVLPDSVDSGQYQALKTFKDSCRKRGLIEEYENLSQFREKLVRQLAQTIIRNFTADEVNLADLPVIRPDPIPSISSAARELLLEATQDTNGVIMRLQTHGGTSVVTHGRNFVSSSDARETARWRSAVDELYRQDMIEDRTGKGEVFFVTDQGYIIADRLRDQSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Z1</accession>
    <name>A0A1W1I4Z1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48066">
        <property type="protein sequence ID" value="SLM48066"/>
        <property type="gene ID" value="NSJP_1894"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1894"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="183" mass="20456" checksum="CCCD20B9BA59BEE8" modified="2017-06-07" version="1">MGKTAKRTTTVTVELGELKAPWQAWCDEHKVTPSHALRNALRQAMDRRATRAPAPRLRVTPKPERATARMEVNLTPSELAALKRMAGHEGCVPTKCVVAMIRTKSTGQPHLGQPELEGLARSNQQLLALGRNLNQIAKVFNTSPRHQVAFRVEVITELSRVIQAHTKKVSDLLRGTVERWHIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I510</accession>
    <name>A0A1W1I510_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48086">
        <property type="protein sequence ID" value="SLM48086"/>
        <property type="gene ID" value="NSJP_1914"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1914"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="448" mass="50437" checksum="50FB4378E7D83F1D" modified="2017-06-07" version="1">MIERILELLNSLSEDAQNAIIKKCKELGFDPNKGDISLEESFINLNSARAILKESIAQSKLIQLPLSVQKNLLPLLENIQRLQAEIINGTDQVVNLVNVIEALHFAVWTFGLHKLSGEVLGLETKMNQLKQLELDATKLKAELQDGLRVKESLDKIQTQASDQAASLHRLLGESHETLRKINDNLSTSSEANQKVGALLQTIQQSDVASSQFSANAKASQSAVAAIENKIQEFLSQIDTYRDKLVKMSTDAENTVAEHSAETGRLISQLKELEDLIKLQIQKATGFSLFHSFQTRKESLVKSKQFWIYAIVGLICISLGFTGWIISTVPETLDTAFYLKLTISIPIIFLITFCTLQYSRERRLEEEYAFKSNISISLIPYQELVDKLTDKSKQAERDRYATFIIESIGKVFSSPTDKVFEDRSASKLSMKSLKEFTDIFEQMQKLLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I543</accession>
    <name>A0A1W1I543_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48041">
        <property type="protein sequence ID" value="SLM48041"/>
        <property type="gene ID" value="NSJP_1869"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1869"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="448" mass="46280" checksum="471B876421E2496F" modified="2017-06-07" version="1">MISMKGDRHDMDRSGDRRAIPVRLPADPPVHDRHRGGAILALSLYLLMIGVMAWVWAVTPAFALVSATGYVRVATDSSKLLYLGANRAALLSTVAQAAAVTSPASVAVRLVTGPIGWAALGVSVGLALYQMHYSDTELQAVKQAAAPSNLQSGTGVVLPNGAALEAAQSCLYPSCTAGQAQIVTVAIPGKTQATCGLNVQPVAFPLPWFSNLGEAWNSGRNSCVQTFRYVYDGSSATNLVRSGVGVATAQQIQDYVAALPASDPKSIESNTTPLGQGASATPAATTTSTAVSPTEIPTTVKPIGQVTSTDAVVDPNAPKPAGTQTVPATQTSTSTTTTTTNPDGSTTEATQESASVSCSGADHDARSFGSVLQAHITTWQGSGMLSAVSLLQTLAWPEALPTITFTSTMWGTHQVDFNQWAAVFTVLRTLTIAGAGFAAYRIIFVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I550</accession>
    <name>A0A1W1I550_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48148">
        <property type="protein sequence ID" value="SLM48148"/>
        <property type="gene ID" value="NSJP_1976"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1976"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="217" mass="24181" checksum="8008B285C51C65D7" modified="2017-06-07" version="1">MPRSLRRLTLIAGCWAAFITPIIASSLAVASPIDQLSDLTGRVSVVVTLKGRDNFNSEYRYDVSAKNLSSETFAGDSLYIVLDKVTNIGGEERENLNSDPILSRMDVLGQEGETSDGKPYFRIPPGANPDLVPYSQSLPVSIRLRNKDYMIVFTPSFKVYGARRPPPEPKQQSQAQPPSPSTNPRHQAQERQTDKLIQLLLKKGVITEEEWRKANQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I552</accession>
    <name>A0A1W1I552_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48126">
        <property type="protein sequence ID" value="SLM48126"/>
        <property type="gene ID" value="NSJP_1954"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1954"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021493">
        <property type="entry name" value="DUF3147"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11345">
        <property type="entry name" value="DUF3147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="139" mass="15091" checksum="E4CBE745D3A2718B" modified="2017-06-07" version="1">MMVGISVSGLKATRLHELVVRFVLGGAITAMTGLTTMRWGPVIGGLFLAFPAIFPASVTLVEAHAVRQKKELGLHGEQRGRDESGADAAGAAIGSLGLMIFGLIMYEYVDTVNYWIVLSLATVGWLTVSIVVWWIWKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I560</accession>
    <name>A0A1W1I560_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1889"/>
    <dbReference type="EnsemblBacteria" id="SLM48061">
        <property type="protein sequence ID" value="SLM48061"/>
        <property type="gene ID" value="NSJP_1889"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1889"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="281" mass="31039" checksum="1CAD5CE5111B6521" modified="2017-06-07" version="1">MRRPQGFMALIPPFFLDCIVAIGLLANDGSKHWVATGFMYGEFYEKVSDETQRYHTFLVTNRHVLAGKTLMFVRANVEGKEPAKEFKLPLQDDKGRPIWFSHPDPAVDIAVVPTGFDAIRQEHKLRLNFFRSDAHVLDLSSASKLGVSEGDGVYVLGFPMELVGGEQNYVIARQGIIARIRDALSGSAKEFLIDTTIFPGNSGGPVIIRPEAVAIQGTQPLGSANLIGVVKGYLPYSEMAISTQTNQPRIIFQENSGLAQIIPIDLVNETIAAYWKSKEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I566</accession>
    <name>A0A1W1I566_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1968"/>
    <dbReference type="EnsemblBacteria" id="SLM48140">
        <property type="protein sequence ID" value="SLM48140"/>
        <property type="gene ID" value="NSJP_1968"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1968"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022440">
        <property type="entry name" value="CHP03788"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03788">
        <property type="entry name" value="marine_srt_targ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="683"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="63"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="353"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="708" mass="77481" checksum="A5EA56EA8389AFBF" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5L2</accession>
    <name>A0A1W1I5L2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferric uptake regulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fur</name>
        <name evidence="3" type="ORF">NSJP_2049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48221">
        <property type="protein sequence ID" value="SLM48221"/>
        <property type="gene ID" value="NSJP_2049"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2049"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="145" mass="16620" checksum="4CAC9998461427C9" modified="2017-06-07" version="1">MASGKSPKEMDALKEHLARHQLKFTRQRELILSAFLRQEHITAEAMYHQLAKTDPHLGLATIYRTLNLFCDAGLAQARHFGSQTQYDNISHKGHHDHLICTGCGKIIEFENCEIERLQEEVAAKNGFTIQTHRLELYGLCSHCRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5L3</accession>
    <name>A0A1W1I5L3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein YciI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yciI</name>
        <name evidence="3" type="ORF">NSJP_1997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1997"/>
    <dbReference type="EnsemblBacteria" id="SLM48169">
        <property type="protein sequence ID" value="SLM48169"/>
        <property type="gene ID" value="NSJP_1997"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1997"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="92" mass="10305" checksum="36803C53612107FC" modified="2017-06-07" version="1">MIFVILGFDGPDGEARRKVYRPAHLANLEPLDRAGRVLLAGPLTDKTGSLIVIEADSLEEARKFALEDPYMVNGVFERVEVHPFTQVFPKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5M2</accession>
    <name>A0A1W1I5M2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rubredoxin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_2103</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2103"/>
    <dbReference type="EnsemblBacteria" id="SLM48275">
        <property type="protein sequence ID" value="SLM48275"/>
        <property type="gene ID" value="NSJP_2103"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2103"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="299"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_2" evidence="4">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="465" mass="53221" checksum="55B804D0F813D143" modified="2017-06-07" version="1">MLRLLTSIFLISAGIFVYSYFRELNPGTLTVHTGPSTQFELSPVTLVVFSMAVGAVLVALAVGMRQTAHAIGTWRSTRLQRRKEKLDALHREGTHAFMSKRISEAIGLFEKALAIDPNRVDSLLWLGNIYRSENNFSEAIRLHQYANRIDDRNIEILLELSKDLEAAKRYEDSLQTLQKILRIEPDNLTALIRKRDLSIRLEKWSEALEIQHRLLKASLPESERRAENLLLTGCMYEVGRQLLERGHPDKARRYFRGAIKKDRTFLPAYIGIGEILIQEGKTKQAVEILKKVYAKTHNVIILHRLEELFLDQGEPSEIIRTYQEALQQNPNDPVLQFYLGKLYYRLEMVDEAFDILSTVEGPQDQLVDYHKIMANLFLRKQHMEQAVVELKKALQFKKRVVVPYVCTACQQETAEWAGRCRRCGNWNSLVALPWLEGGVPSAGKESPLPVRVVPYPGIASPFETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5N1</accession>
    <name>A0A1W1I5N1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thiamine thiazole synthase</fullName>
            <ecNumber evidence="4">2.4.2.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">thi4</name>
        <name evidence="5" type="ORF">NSJP_2079</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycine + hydrogen sulfide + NAD(+) = ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:55704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:139151"/>
            <dbReference type="EC" id="2.4.2.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooctamer; tetramer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the THI4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.59" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2079"/>
    <dbReference type="EnsemblBacteria" id="SLM48251">
        <property type="protein sequence ID" value="SLM48251"/>
        <property type="gene ID" value="NSJP_2079"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2079"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00304">
        <property type="entry name" value="Thi4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002922">
        <property type="entry name" value="Thi4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022828">
        <property type="entry name" value="Thi4_prok"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00292">
        <property type="entry name" value="TIGR00292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="61"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>glycine</name>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="266" mass="28780" checksum="8B15F0EFBCF1AA06" modified="2017-06-07" version="1">MGKPKPAPLRERDITRQIAREYYKEFDQLIESDVIIVGAGPSGLICAHDLADMGFKTVIVEQNLALGGGFWHGGYLMNKATICAPAHKILDEIDVPCKRIKDCEGMYIVDPPHATGALIAAAYRAGAKVLNLTRVVDLILRRDGSLDGVVVNNTTAEMAGHDLIHVDPIALESKIVVDATGHDAVVVSLLHKRSLYTEVPGNGAMWVSRSEEDVMDHTGEVYPNCFVIGLAVSAVHGTPRMGPAFGSMLLSGRYGAELIKKKLKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5W1</accession>
    <name>A0A1W1I5W1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2212"/>
    <dbReference type="EnsemblBacteria" id="SLM48384">
        <property type="protein sequence ID" value="SLM48384"/>
        <property type="gene ID" value="NSJP_2212"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2212"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="182" mass="20173" checksum="C7F699D7470045A7" modified="2017-06-07" version="1">MAAADLGHVNGELIRYRTTVLRAIEAETKADFVRIAASLPNVHSRIDKAIQRFVDATNDASPGKNMDARELEELKNVQQRLTAYIDSSHYTIELLKNRWEAKSANEASRLRKAAEEHAAKDAGRKLIGVTLELDRLLEVVAEIAGEVRKEADVSLRIATMEFMVTSVLLAALVLILPVRRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5X6</accession>
    <name>A0A1W1I5X6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_2061</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2061"/>
    <dbReference type="EnsemblBacteria" id="SLM48233">
        <property type="protein sequence ID" value="SLM48233"/>
        <property type="gene ID" value="NSJP_2061"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2061"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="214" mass="23486" checksum="84F73A770C44E2DA" modified="2017-06-07" version="1">MKKPRILLADDHTLVLEGFKKLLEDHCDLAGTVEDGRALVEAAEQIRPDLILLDIAMPRLNGIDAAKKLKRLLPEVKLIFVTMHADTAYISEAFKAGASGYLLKRSAGKELVQAIQCVMGGNYYVTPLVTKDVISSFLTPGQPRIAVADDLTMRQREILQLVAEGFSAKEIAAQLKVSHRTVEFHKAKIMELLDLHTTADLVKYAVAHGLVASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Z2</accession>
    <name>A0A1W1I5Z2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2238</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2238"/>
    <dbReference type="EnsemblBacteria" id="SLM48410">
        <property type="protein sequence ID" value="SLM48410"/>
        <property type="gene ID" value="NSJP_2238"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2238"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="475" mass="53148" checksum="F88CB5D6BABF3E14" modified="2017-06-07" version="1">MGIRQWLVDHLNKPRTNVVASILEFPAIDIDGMTKRLNLKRLAKEKGEQGIPRPDNETFDATEHSIISEIETEGKIQFNKYLEHQKTYAERAGDASASGLLIKISSAAGDAITNFERKTHVGTGDLYASKRDVMQSDAELTTFKNLHALTRPPHDLGSRTYKIGILILILAIESVLNGFFLAKGHEFGLIGGVSQALIIAGINVFGGAAVGRLVLPWLNHRNLNARAVATVATLGYLFIDVGFNLAVAHYRNAVATDPFEASAVAYRSLLADPLGLNDLQSWLLFLVGFLFSNVALYDGFRMDDPYPGYGRRMRQNLQALDDYNDLKEQLLGELDEIKTSAEEEIDETVRDIGTKQGEFDYIVRKSQALRTNMLQHFMHLGLAGNTLLRFYREENMRHRPAHSPSPARFNQQWKYEPPPLAGEDVSPADPEVSRSVSVQALEEAKKQREALHNNYRKACDEYKRIDDLVEPSTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I616</accession>
    <name>A0A1W1I616_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2268"/>
    <dbReference type="EnsemblBacteria" id="SLM48440">
        <property type="protein sequence ID" value="SLM48440"/>
        <property type="gene ID" value="NSJP_2268"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2268"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12837">
        <property type="entry name" value="Fer4_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="98" mass="11195" checksum="168E4863B1DE87BB" modified="2017-06-07" version="1">MSSLPKKNMFEIFSQGLFEGVKPMMVIRDHLVRHPDRCLHQAICVPICPTSAWLSTPPYKFDPSRCLESCRLCLDACPSQAIYAVFRKGDKLLEPQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I657</accession>
    <name>A0A1W1I657_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tufB</name>
        <name evidence="7" type="synonym">tuf</name>
        <name evidence="9" type="ORF">NSJP_2324</name>
        <name evidence="10" type="ORF">NSJP_2336</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2324"/>
    <dbReference type="EnsemblBacteria" id="SLM48496">
        <property type="protein sequence ID" value="SLM48496"/>
        <property type="gene ID" value="NSJP_2324"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48508">
        <property type="protein sequence ID" value="SLM48508"/>
        <property type="gene ID" value="NSJP_2336"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2324"/>
    <dbReference type="KEGG" id="nja:NSJP_2336"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="10"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM48508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="401" mass="43645" checksum="C0C232CE02E440CE" modified="2017-06-07" version="1">MAKAKYERKKPHVNIGTIGHVDHGKTTLTAALTKVCADKGMAKFISYDEVAKASESQGRRDATKIMTIAISHVEYETDKRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPYIVVFLNKADKVDDKELLDLVELEVRELLSKYDFPGDKTPIVQGSALKAMEGDGGPLGVPAIMKLLDAVDTYIPTPQRPIDKPFLMPVEDVFTISGRGTVVTGRCERGIVKVGDEIEIVGLRPTQNTVVTGVEMFRKVLDEGQAGDNIGVLLRGTKKEDVERGMVLAKLKTVTPHTKFKAEIYVLTKEEGGRHTPFFNGYRPQFYFRTTDVTGIVSLNPGVEMVMPGDNVSVTAELISPIAMDQGLRFAVREGGKTVGSGVVTEILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I697</accession>
    <name>A0A1W1I697_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48399">
        <property type="protein sequence ID" value="SLM48399"/>
        <property type="gene ID" value="NSJP_2227"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2227"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="425" mass="47335" checksum="8F3E0EFEA8BA39B5" modified="2017-06-07" version="1">MTEIWWEQVREQCPHLQKVDLLVGLLTFNQAANVEAVTRVVLTGLQKSFPNSSLLLVNVDVGSQDGTPEIIKRTVGSLVPLAMLQQPADDGRMNPFAVNRMSYSGMPGREAAFRCLFAMTERLQATACVVIDANVRSVAPEWIPLLGQVVLEKSADYVAPMFRRPRYEGSLTNSLIAPLTRALYGQRVACQTGGGYGFSRRMASLYLQERVWEGDGARFAIDSWLTTVAVAEGCQIWQAFLGAKIEDVKATGADVAGVLAQAVGATFHCMERYEDRWESLSGSTVVPEVGQPMQGGTESHTIKVERMVNGFRQGLRDLLPIWEIILAPDTLAGILPLGLSQEDDFEFPLPLWVQTVYDFAIAYHEKLIHREHLLRSLTPLYLGRTASLVLETKDAGHAEVERTIEQGCQIFESMKAYLVERWRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6E3</accession>
    <name>A0A1W1I6E3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2382"/>
    <dbReference type="EnsemblBacteria" id="SLM48554">
        <property type="protein sequence ID" value="SLM48554"/>
        <property type="gene ID" value="NSJP_2382"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2382"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012484081" evidence="2">
        <location>
            <begin position="31"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="496" mass="53785" checksum="68EEFB2997088623" modified="2017-06-07" version="1">MKGGRKRHHVLGSIGVAVVTLALFSAVASAAEAQSAGESTGAGRKSREMQSPPASSEPSMGNEEGQSAGESTGGGRLSRETQTPPAVICGGCVTHTHDAQAKGSIVPYGRIELDGIYSTRNTNPLDPGQFNGYATAAGKSSNSSSTFNPRYSVFGLRADRTDGANVITGVVETDFYSQTDNAGNISPRLRLAFARYSPNNSRTSVTAGMDWTPVMGLHPNLVDFSIMGYNGNLWQRLPQVTVRHQFSEHIDALVTVFRFERGLSAIQPQTQRRPFTGNGVGGVPPVSCNNPTGNFACSENAFNDPVQMPYTGTRFGYNGTGKLQGMMVAVSGAYRWYRSAPTALVGGIPSGQDINSYVIGGELVVPITRQLKFSGEIAYGQALGVEFFRFGQDRNLGTGKPIRTTVGWGEIDYAHDKDTTFIAGYGFDNPLNSDLKGDVAGPDTQYLLNHRTYVTAVRHIWSDFYMSFEWNHLMTEWSTNERFAGDNFMLSTWYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6H8</accession>
    <name>A0A1W1I6H8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48600">
        <property type="protein sequence ID" value="SLM48600"/>
        <property type="gene ID" value="NSJP_2428"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2428"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="47" mass="4956" checksum="4CB91A2B3194AEFD" modified="2017-06-07" version="1">MPIVLAALSAIGLLSALLADGIWDVLSWVTLSSPLAVMVWSMARRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6I7</accession>
    <name>A0A1W1I6I7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48489">
        <property type="protein sequence ID" value="SLM48489"/>
        <property type="gene ID" value="NSJP_2317"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2317"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="151" mass="16616" checksum="8B7DAA7CE4A23EA6" modified="2017-06-07" version="1">MWKFIGVLVLITGSFAAGFYFGQRPTGTLEQTVAGLPKSIREVSRNVMDTTMGIEQDLRRRQALLETKSKIVQARSEVLDKNFGEAAKQLADGVAGLEAAIKGARQDGSTQAVRSIIGTLQELRLELSMGKPVPMKKLNDVQKEIDRQLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6M0</accession>
    <name>A0A1W1I6M0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">guaA</name>
        <name evidence="12" type="ORF">NSJP_2485</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2485"/>
    <dbReference type="EnsemblBacteria" id="SLM48657">
        <property type="protein sequence ID" value="SLM48657"/>
        <property type="gene ID" value="NSJP_2485"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2485"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="202"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="229"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM48657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="518" mass="57858" checksum="672A2FA0E703999F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6S9</accession>
    <name>A0A1W1I6S9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2550"/>
    <dbReference type="EnsemblBacteria" id="SLM48717">
        <property type="protein sequence ID" value="SLM48717"/>
        <property type="gene ID" value="NSJP_2550"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2550"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012732213" evidence="1">
        <location>
            <begin position="33"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="158" mass="17445" checksum="6966BF29CE6CC00D" modified="2017-06-07" version="1">MLTMPSRTLTPFAVFALAVTLALPLIQNRAAAAEGQEQGKVKVLYHVDGKDPEVAKYALALINKHIDAEGGPDKIDVELVVHGPALELFEKDRMDPEMTKRFDQIIEKGTKAEMCQVSMKAFGRTLDNLAKGFVATQHPVAVKRIADLQKEGYLYIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I765</accession>
    <name>A0A1W1I765_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48862">
        <property type="protein sequence ID" value="SLM48862"/>
        <property type="gene ID" value="NSJP_2695"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2695"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="52" mass="6153" checksum="F9112CCCC403D57E" modified="2017-06-07" version="1">MEVHEEWSWREELNLQPVVYKTTALPLSYASFRLFGEYFSHGREGARMRCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I781</accession>
    <name>A0A1W1I781_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2699"/>
    <dbReference type="EnsemblBacteria" id="SLM48866">
        <property type="protein sequence ID" value="SLM48866"/>
        <property type="gene ID" value="NSJP_2699"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2699"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021383">
        <property type="entry name" value="DUF3015"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11220">
        <property type="entry name" value="DUF3015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010692395" evidence="1">
        <location>
            <begin position="25"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="123" mass="13787" checksum="EA7000BD178EFE25" modified="2017-06-07" version="1">MRRMYTHSLCMSLLLVSMTGCSFAPSFFDVTPDTASDSTHAWWTEDGLVKPDYKLVAFAAYGWLDLEQDFARGEGEHLASLASVLGVEEDSRLTFEAAAQQRFEAVVPPDRTIHMQQLRALVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I797</accession>
    <name>A0A1W1I797_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2688"/>
    <dbReference type="EnsemblBacteria" id="SLM48855">
        <property type="protein sequence ID" value="SLM48855"/>
        <property type="gene ID" value="NSJP_2688"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2688"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008023">
        <property type="entry name" value="DUF748"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05359">
        <property type="entry name" value="DUF748"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="519" mass="58078" checksum="0F6DCD1C11F16C07" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7F6</accession>
    <name>A0A1W1I7F6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2785"/>
    <dbReference type="EnsemblBacteria" id="SLM48952">
        <property type="protein sequence ID" value="SLM48952"/>
        <property type="gene ID" value="NSJP_2785"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2785"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="137"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="202"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="255" mass="28078" checksum="A918A430288C2F88" modified="2017-06-07" version="1">MAVRTMSRKPRISIDRGIERMRKQLADLAQHVKKRTPSRPLEEFDLETVHLIADSLGETSPLVDAYEYAQLGEAAGLVNMTEEAPESVGLDSERQSLMQRGRVLESCISEMEARRAAVPKKQSGRQILTGPQVAEHMSAELRSIPQSATLREAGQLMQKWKTGSLLVTNSRTYVGFITDSALARDVVANGLDPTKTSVQTCARTPIVAIRGDRPLIEAVRLMKEQATRHLAVAQDGEIIGVISVSNILRYYSGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7S1</accession>
    <name>A0A1W1I7S1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48853">
        <property type="protein sequence ID" value="SLM48853"/>
        <property type="gene ID" value="NSJP_2686"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2686"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012800037" evidence="1">
        <location>
            <begin position="19"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="484" mass="49755" checksum="D8909876E5D6B664" modified="2017-06-07" version="1">MWAIIVALLVMLVGCSSGGGGGTSDATPISSAPASPAGLIWGRTAGSQESLFRSQSDGSGQVTLVDEQGIRATFAKLAGSLVIYQTQAVPFSGGDQRDIWKVSTSGVGRQALANATDDEIVRDVVGSRVIYDQIISLPSGVRLNDLTSVVTDGSGRAVIAAAVRTPGSESIANYEGSVAGKVVYSRNSGLYSLLPDGSDLRPLVNAPGSPSGQYTFTGMQGSVGSSVIFSARPSSPPLPDLYDVPVNSGAIVPLASDPDNDFLGGVNGNRVVYHRCSGPCDLYSVASDGSGTVPLSTDPGNEFLEEMVGGRIVYTRSVNGQTDIYSVNADGTNPVPLATSPANEGVEGKVGSRVIFRRTDSNGNDNLYSIQADGTGGEIPLATFSEDDSFGGVVGSRVIFERIMGSNVMSSPRALYSVLSDGTGLEQLTPGTSLDEFAGAAGGFACFERTQSGQRDLLCVPADGSSPAVPIAATSADEYFITGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7W9</accession>
    <name>A0A1W1I7W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48903">
        <property type="protein sequence ID" value="SLM48903"/>
        <property type="gene ID" value="NSJP_2736"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2736"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="71" mass="7922" checksum="6FDF5EFD9775DEF5" modified="2017-06-07" version="1">MNQNRSQFLSAARRFGRLAHAYVSSQSVGHSPSANILNEMPIRKGRPADRMDRTDGPSPSCQRMSYSNVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Z2</accession>
    <name>A0A1W1I7Z2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49105">
        <property type="protein sequence ID" value="SLM49105"/>
        <property type="gene ID" value="NSJP_2938"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2938"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="192" mass="22198" checksum="D6BF807AAD36364B" modified="2017-06-07" version="1">MVTLPSSCEPALLERFLKAEAMALWSVRAAQVRDVPPGVLAFLRRHEEEEAEHLREFEARLGVISHTREKLPRVPSQWWALVIHLYGYETLGLEFAKLLVQVQPELQSILDDETVHVGFFEDEVRKVLAQEGRGATEARKSAQAWWRRLPPTVDRYLEGEQLAPYRIDLKRLILDSIEERFTNIGLFNAVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I834</accession>
    <name>A0A1W1I834_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49208">
        <property type="protein sequence ID" value="SLM49208"/>
        <property type="gene ID" value="NSJP_3041"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3041"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012574135" evidence="1">
        <location>
            <begin position="22"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="140" mass="15966" checksum="5F7657F91365AA58" modified="2017-06-07" version="1">MLSSVCALGISWAISCPNAFSAEAPPCNDEDVLYKVRRAYEFALSVDKSSHKFRGEAVKETHYGGPNPWVNKHAPSKDYYHKSRYCEATMRLDNGQTEQAYFRIDALKAGEADKYNFDPCFIKHQDASRDDCLYQRSPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I868</accession>
    <name>A0A1W1I868_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49248">
        <property type="protein sequence ID" value="SLM49248"/>
        <property type="gene ID" value="NSJP_3081"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3081"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="57" mass="6611" checksum="6C8829643CE20A47" modified="2017-06-07" version="1">MLERQAPDTRINKVSFVVLSRPYGPAQCIVYFFELNVYYGQWWKGVPLCESILPISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I881</accession>
    <name>A0A1W1I881_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49232">
        <property type="protein sequence ID" value="SLM49232"/>
        <property type="gene ID" value="NSJP_3065"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3065"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="99" mass="10405" checksum="569BD1A3BCA08A1F" modified="2017-06-07" version="1">MSVVSCRSGRPGYGYLPEVRHRRSRLQRKAVCDAAPGLLATAEKPRPTEPRGPGGLTGDGHPGTQGRLGRKEAGGNKGHGTEQARTNAPVRLAQRAGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8J3</accession>
    <name>A0A1W1I8J3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal RNA large subunit methyltransferase L</fullName>
            <ecNumber evidence="4">2.1.1.173</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rlmL</name>
        <name evidence="4" type="ORF">NSJP_3175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.173" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3175"/>
    <dbReference type="EnsemblBacteria" id="SLM49342">
        <property type="protein sequence ID" value="SLM49342"/>
        <property type="gene ID" value="NSJP_3175"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3175"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052915">
        <property type="term" value="F:23S rRNA (guanine(2445)-N(2))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="47"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="394" mass="44301" checksum="AB2090C36CD8F9E9" modified="2017-06-07" version="1">MDNIKQRFFAPCPRGLETILQRELDALGIASAEVTQGGVSFTGHWNALYHVNLESRVANRVLLELGHARYRTEADVYRAAYALDWPAWFDPGRTIRVKVSARHCPLASLNFVTLRIKDALCDKFMAACRRRPSVDTQQPDVRIDAFLDAESVTFYLDTSGEPLFKRGYRFAQIEAPIRENLAAGMVLLSGWTPDQPFVDPMCGGGTIPLEAALIARRIAPGLRRVFAFERLRLHTPDRWNAIRAAAEARQLAASPQPIYASDRDEQAIQIAKRLFHAARMIQDIDVKVKQEDFLKLDPPAPRGVMVANPPYGVRLGHSEQSAILYAGIGNRLKQQWAGWQVHIFTGDPKLKESIGLLPSRRIPLYNGPLECRLYEFKIVEGSMRKHARSANLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8N1</accession>
    <name>A0A1W1I8N1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49345">
        <property type="protein sequence ID" value="SLM49345"/>
        <property type="gene ID" value="NSJP_3178"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3178"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="67" mass="7355" checksum="6009F23EFAF08644" modified="2017-06-07" version="1">MDIGSLSPTQLKELVRGIVDDRLRELLGDPDLGLQLGEALRTRLKASLGNAERLSGEEVADKLGLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8N9</accession>
    <name>A0A1W1I8N9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="7">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">trpA</name>
        <name evidence="9" type="ORF">NSJP_3207</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3207"/>
    <dbReference type="EnsemblBacteria" id="SLM49374">
        <property type="protein sequence ID" value="SLM49374"/>
        <property type="gene ID" value="NSJP_3207"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3207"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="272" mass="29262" checksum="C6F056A49E0B44B2" modified="2017-06-07" version="1">MTSRLDRTFSRLRDGRQAALITYVMAGDPSLHETEQLVPKLEEAGADVIELGVPFSDPIADGPVIQQAAERALRSGTSLRAILQMVSRLRQHTQIPIVLMAYYNSIHAFGLERFCREAGAAGVDGLIVPDMPPDESKPLKEPAAASGLQLIFLLAPTSTNQRRTYVARQSKGFVYYVSLTGITGAKLNNVDEVRRNVEKIRKISPTPVAVGFGVATPEDAGNVAAVADGVIVGSAIVKQIAAHRQDAGLVEHVAGFVHALKSAMTARQTSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Q9</accession>
    <name>A0A1W1I8Q9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin/lipoate A/B protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3229"/>
    <dbReference type="EnsemblBacteria" id="SLM49396">
        <property type="protein sequence ID" value="SLM49396"/>
        <property type="gene ID" value="NSJP_3229"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3229"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="44"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="250" mass="28240" checksum="E2F33AD192FE4A3C" modified="2017-06-07" version="1">MDIPPISTPSANGRHRFRLLDLTLPSPVENIALDEVLLDQMEEHGGEPLLRFWESDRCFVVLGRSSRAGDDVHVAACERDGVEILRRISGGGTVLQGPGCLSYALVARQDLHPDLESIRTTNRFVLDRIASVIRRWEPDTVFCGISDLAVGERKISGNAQRRTRRSLLFHGTLLHGMDGALIARYLKQPARQPNYRQDRPHEDFVRTIDAKPDDLKQAMALVWHAVLPSVEWTESRLQAGIRNVLERSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8U3</accession>
    <name>A0A1W1I8U3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Addiction module antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49437">
        <property type="protein sequence ID" value="SLM49437"/>
        <property type="gene ID" value="NSJP_3270"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3270"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="80" mass="9304" checksum="93C6CBEA5CA4C1BE" modified="2017-06-07" version="1">MKYESGCDGVSTYSLCYKPSVERDLHSIPHTIASRLLDRIDRLTSDPFPPQSIKLHGAERLYRLRVGDYRIVYEVDREFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Z1</accession>
    <name>A0A1W1I8Z1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">mutY</name>
        <name evidence="12" type="ORF">NSJP_3182</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3182"/>
    <dbReference type="EnsemblBacteria" id="SLM49349">
        <property type="protein sequence ID" value="SLM49349"/>
        <property type="gene ID" value="NSJP_3182"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3182"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="11">
        <location>
            <begin position="86"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM49349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="266" mass="30246" checksum="6DB72179CCC3D3E1" modified="2017-06-07" version="1">MIGGAPDPRLILQERAPYNAGTGLRFMIRRTTPARSRKAVNRRPKLTRSLKRRFQLRLLKWYAANGRDLPWRNTADPYHILVSEVMLQQTQVDRVIPKYHEFLDRYPSFQHLAEAPVGEVKTTWYPLGYNIRPERLHSIACETVARYGGKLPSTEEDLLSFKGIGRYTAGAIRSFAFNEDAPILDTNVMRVLHRVFIAKGDPKASKSILWALSETLIPKGRGYDFNQALMDFGATCCTSRNPSCRPCPMKSICKTYPFGAGRTKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I909</accession>
    <name>A0A1W1I909_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type 2 DNA topoisomerase 6 subunit B</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Type II DNA topoisomerase VI subunit B</fullName>
            <shortName evidence="3">TopoVI-B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">top6B</name>
        <name evidence="6" type="ORF">NSJP_3351</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Relaxes both positive and negative superturns and exhibits a strong decatenase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer. Heterotetramer of two Top6A and two Top6B chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TOP6B family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3351"/>
    <dbReference type="EnsemblBacteria" id="SLM49518">
        <property type="protein sequence ID" value="SLM49518"/>
        <property type="gene ID" value="NSJP_3351"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3351"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00823">
        <property type="entry name" value="TopoIIB_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00322">
        <property type="entry name" value="Top6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005734">
        <property type="entry name" value="TopoVI_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015320">
        <property type="entry name" value="TopoVI_B_transducer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF4">
        <property type="entry name" value="PTHR10871:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09239">
        <property type="entry name" value="Topo-VIb_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01052">
        <property type="entry name" value="top6b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="HATPase_c" evidence="5">
        <location>
            <begin position="66"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="572"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="622"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="144"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="154"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="690" mass="75323" checksum="A979C8E12DB0A935" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I923</accession>
    <name>A0A1W1I923_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">lgt</name>
        <name evidence="3" type="ORF">NSJP_3361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3361"/>
    <dbReference type="EnsemblBacteria" id="SLM49528">
        <property type="protein sequence ID" value="SLM49528"/>
        <property type="gene ID" value="NSJP_3361"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3361"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="276" mass="30565" checksum="9D8CC07CC517F2DC" modified="2017-06-07" version="1">MNRLAAIPYPNIDPVFLELGPLQFRWYGLMYLIGLTIAYFVIRQKAEAQGLGLTKDQVYDMVVWAAFGVFIGGRFGYVLFYNLPYYLEYPSKILAVWEGGMSFHGGLIGTIVALIWFGKRHGVPIYTIADMAASVTPIGLGLGRLGNFINGELFGRPADVEWCMVFPAGGPACRHPSQLYELGLEGVLLFSALWVIGRRPTPPGTVFWSFITGYGLCRLLAELFREPDAHIGFIFGAISMGQLLSLPMVVIGSFMLALGYQRQALARRIDPSLKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I942</accession>
    <name>A0A1W1I942_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49323">
        <property type="protein sequence ID" value="SLM49323"/>
        <property type="gene ID" value="NSJP_3156"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3156"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="96" mass="10831" checksum="83C14D84813011DB" modified="2017-06-07" version="1">MSRFVGHCVVMGVKSRPSQDGKRIFRNAVLYFEEDTSTLEASVSEDHEHLYKLMEANKMKPCQITVNLREFKGQRFLDVTGYQPGLVAPGAKGPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9D4</accession>
    <name>A0A1W1I9D4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49413">
        <property type="protein sequence ID" value="SLM49413"/>
        <property type="gene ID" value="NSJP_3246"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3246"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="229" mass="24472" checksum="826BE004805FFFED" modified="2017-06-07" version="1">MPSIALVTGANRGIGYEVARQLATRGWIVFLTGRTLAAVKRAASSIDSSVTPIPLDVTSRVSIEAAFGIVSQTVDHLDVLINNAGILDQDEGSIFDLPPERLRRMFETNTIGSLLMTQTFLPLLRKSGSARIINVSSGAGQLTDMDTWAPAYSISKTALNGVTGKFAAALKDSNIAVNSVCPGWVRTDMGGNEAPRSLEEGADTIVWLATEAPISLTGQFIKDRKVIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9H1</accession>
    <name>A0A1W1I9H1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 2,5-diketo-D-gluconic acid reductase</fullName>
            <ecNumber evidence="2">1.1.1.274</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.274" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3497"/>
    <dbReference type="EnsemblBacteria" id="SLM49664">
        <property type="protein sequence ID" value="SLM49664"/>
        <property type="gene ID" value="NSJP_3497"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3497"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050580">
        <property type="term" value="F:2,5-didehydrogluconate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="24"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="286" mass="32013" checksum="94827C3A4DB24C11" modified="2017-06-07" version="1">MMENSEDTVIAHNGIRLPSFMYGTAWKKEATTQLVVTAVQAGFRAIDTANQLIHYEEARVGEALGLLAEQGVSREGLFVQTKFTPLNGQDHRTPYDPRAAVSVQVEQSFESSLQHLRTDYVDSYVLHGPYGRRGLGPEDWEVWAAFERLYEAGKVKMIGISNVTSEQLALLCERAKVKPMVVQNRCYAAFGWDKGVREICQAQDIVYQGFSLLTANREVSIDPDIRAMAGRYGMGLAQLIFRFAMQIGMLPLTGTTNLQHMAEDLACRNFTLTDPDLREIESIGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA53</accession>
    <name>A0A1W1IA53_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3708"/>
    <dbReference type="EnsemblBacteria" id="SLM49875">
        <property type="protein sequence ID" value="SLM49875"/>
        <property type="gene ID" value="NSJP_3708"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3708"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021796">
        <property type="entry name" value="DUF3365"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11845">
        <property type="entry name" value="DUF3365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="202" mass="22158" checksum="511A5D6E42ECFBC3" modified="2017-06-07" version="1">MRAQGFGLGLIIGMLLMWASGQGLPSATGKNLPEPPCIPATAATDYVHSVIQADRTFYTTEIVERMQVRGTAVASEHWKERGMLPLPAQFLKEAGLLMRGDDRGIRVRLLSQWPINKDNRANTDFERTGLSEIMVDGGRPYTGVVTQDGASYFQALYPDKAVSQTCIGCHNAHPNSPKKDFKLRDVMGGILVTMPLSQSSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA74</accession>
    <name>A0A1W1IA74_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-directed DNA polymerase (Modular protein)</fullName>
            <ecNumber evidence="2">2.7.7.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3780"/>
    <dbReference type="EnsemblBacteria" id="SLM49947">
        <property type="protein sequence ID" value="SLM49947"/>
        <property type="gene ID" value="NSJP_3780"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3780"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03487">
        <property type="entry name" value="RT_Bac_retron_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000123">
        <property type="entry name" value="Reverse_transcriptase_msDNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00866">
        <property type="entry name" value="RNADNAPOLMS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="551" mass="61610" checksum="D2BBE849B1153AE3" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAA0</accession>
    <name>A0A1W1IAA0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49920">
        <property type="protein sequence ID" value="SLM49920"/>
        <property type="gene ID" value="NSJP_3753"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3753"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008020">
        <property type="entry name" value="G8P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05356">
        <property type="entry name" value="Phage_Coat_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012506565" evidence="2">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="66" mass="7107" checksum="6CAA7AA1A6612CB2" modified="2017-06-07" version="1">MKIRVGIGMLILLLMALPAFAQVFPVDATSTTTITNVKADLIAWGVAFIGVALTVFAYKRVKALVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAB1</accession>
    <name>A0A1W1IAB1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thiopurine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tpm</name>
        <name evidence="9" type="ORF">NSJP_3684</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.</text>
            <dbReference type="EC" id="2.1.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.67" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3684"/>
    <dbReference type="EnsemblBacteria" id="SLM49851">
        <property type="protein sequence ID" value="SLM49851"/>
        <property type="gene ID" value="NSJP_3684"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3684"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008119">
        <property type="term" value="F:thiopurine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00812">
        <property type="entry name" value="Thiopur_methtran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022474">
        <property type="entry name" value="Thiopur_S-MeTfrase_Se/Te_detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025835">
        <property type="entry name" value="Thiopurine_S-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023956">
        <property type="entry name" value="Thiopurine_S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03840">
        <property type="entry name" value="TMPT_Se_Te"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="212" mass="24252" checksum="1A11AD5FAD88DBB6" modified="2017-06-07" version="1">MEHSFWHQRWEENRIGFHESKVNPLLVSHVGELSLAKGRRIFLPLCGKTLDISWLLSKGYRVVGAELSQLAIEQLFTELGAQPEISKVGELEQWSANNIDIFVGDIFRLSKKILGPVDAVYDRAALVALPEEMRNRYAAHLMEITGKSQQLVICYYYDQRLMEGPPFSVSDEEVQRHYADHYDLRLLASAHATGKLAEQCAAKENVWLLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAB4</accession>
    <name>A0A1W1IAB4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49932">
        <property type="protein sequence ID" value="SLM49932"/>
        <property type="gene ID" value="NSJP_3765"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3765"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011473">
        <property type="entry name" value="DUF1579"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07617">
        <property type="entry name" value="DUF1579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="205" mass="22029" checksum="B9DCE7A2085E441E" modified="2017-06-07" version="1">MTTQAEMLMALHEFVGEWDVTQKIWSGPNATPSINRGKTKCTTLLGGAATLMITEMETSNFKGVALMTYNPKLGRYDMAFIDCISDEGIALMQGEHKPAAAADHLRAEFGKMATQAREWRMVGVGEGGEADGVDALAANVTSNAVPACLSGSVVKETALAENVSADDLAPTFRMVENKISDDHWVLDFFLGGTLVQQNSFVRAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAC1</accession>
    <name>A0A1W1IAC1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 23S rRNA methyltransferase RlmB</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3831"/>
    <dbReference type="EnsemblBacteria" id="SLM49998">
        <property type="protein sequence ID" value="SLM49998"/>
        <property type="gene ID" value="NSJP_3831"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3831"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="33"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="267" mass="28951" checksum="34BA2D3605F84001" modified="2017-06-07" version="1">MSSVIPPLTRAQTAHIRELIRDKRARETDGTFVIEGAKAVRDLLAHHPSLVRFVVTTPAYRDGEEPRDLRVRLAAACPSYTCSESLFAGISNLDTAQGILAVARQPEWNEAEVMDRPTLFGIYGEGIQDPLNVGTIIRTAAALGVSALWLTPDSADRFHPKVVRATSGGLLCLPVFMTDSVIPLTRRGCCLFSAEVGGPGVVELEKIEHVPPRLLLAVGSEGQGLSEHTKRLAIRRVTIPLSRDMESLNVASTVAIAAHVLQRLPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAD0</accession>
    <name>A0A1W1IAD0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Vitamin B12 import system, periplasmic binding protein BtuF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3556"/>
    <dbReference type="EnsemblBacteria" id="SLM49723">
        <property type="protein sequence ID" value="SLM49723"/>
        <property type="gene ID" value="NSJP_3556"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3556"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="111"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="371" mass="40512" checksum="8EF306531F69C4FB" modified="2017-06-07" version="1">MTLPRRTFRTCRPSRSSSGVLDAERTVCSPAKAVAQRLFGQAGVFRSCLLFGLCLVLFVFGVVDVQEAESAMMPRRQQGILTGMPFMANITPRTFVDDAGRKLYIAKAPSRVVSLAPSITEMLFALGLDEQIVGVTELCDFPAAALSKPKVGYARHNLEALIALRPDMIVAPQEFLRSDVVAKLEELKIPVFLMDAKTVDDILMQIQSLGKIFNKTKVSDEVTGRMRERIAAVAKQIAASNKKRVLYVLNSHPLITVGPGSYIHQMIGLAGGINVAHGAASPYPTLSIETVLQEDPEVIIFPVGPVESVPKSEQNEWNRWSSLSAVRHRQLREVSSDALNRPGPRVVEGLELLARAIHPEVSLSDNAAPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAE9</accession>
    <name>A0A1W1IAE9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49970">
        <property type="protein sequence ID" value="SLM49970"/>
        <property type="gene ID" value="NSJP_3803"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3803"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="410" mass="44466" checksum="4F82BA85196B1A12" modified="2017-06-07" version="1">MTHSSTPFDEEGASAWNQPTPVPSILTEVGYYTYLFYTLLGAAFGLFVSNLGTGFLLLLLILCVFQLRFRFLTVIHLAAFPLSCAATYVLIQLVVHDEPLLGTVRSFILWGITLLVVQSLALKTNFLRRFAWAAFFIGIAFIPFIQIFALAGGYQRLGLDRAVGYANPNSMAEWYGFCAVYFSVLAFLTKRNLARLFSWLAASVCLYMVTLAVSRATLVAVVVAILIAGRHLLKHGLLPILMLACLTGIVVELGLFGEAVRSYGARGTEETGRLAVWPLVLESFVGSPLVGVGESHTGAMVDTGRYLTPHNCLLFLAQASGIIPLVLFSCYLLQAARVTFLEDLGSTPEGPFSQPLVIYTLLFVQSGDFDFMMPVATVALATPLAASLGQTDRAVLQAPRGRSLELQGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAG2</accession>
    <name>A0A1W1IAG2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rplM</name>
        <name evidence="5" type="ORF">NSJP_3586</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3586"/>
    <dbReference type="EnsemblBacteria" id="SLM49753">
        <property type="protein sequence ID" value="SLM49753"/>
        <property type="gene ID" value="NSJP_3586"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3586"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="142" mass="15865" checksum="3A073D1848594444" modified="2017-06-07" version="1">MSTYLQNPMDVQEKWYLVDAEGKTLGRLAARVAAILRGKHRPTFTPNVDMGDHVVIVNAEKIHLTGDKLETKLYRTHSGYPGGLKTSTAKHVYRKDPTRLLTSAIEGMLPKTPLGKHMAKKLRVYVGTTHPHLAQQPETITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAJ1</accession>
    <name>A0A1W1IAJ1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3616"/>
    <dbReference type="EnsemblBacteria" id="SLM49783">
        <property type="protein sequence ID" value="SLM49783"/>
        <property type="gene ID" value="NSJP_3616"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3616"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="32"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="258" mass="28805" checksum="36DF604F8F54CC5F" modified="2017-06-07" version="1">MGAWSLPKHDYWSTPFAESLLKHLDLFTGATILDVASGHGIPAFYLAEHVGPSGQVLGIDVNARQVASARMIQGDQLRWLSFQCLDVRSLPANLPSFDRITGNLSVMFFRPDRFATLEGLSAHLKPGGQIVVTFPSLGTFDSLWRRVDQEMAVRQLRTERRRLEAYIAERPSAEEGRGWLHKLGFERIVVSEYPLEVVAGHGQAFLHDPLLRGGFLDDVYECFEDPRLADTVMTAVSEDVPSFVPLVAQRCVLSGWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAT1</accession>
    <name>A0A1W1IAT1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3716</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3716"/>
    <dbReference type="EnsemblBacteria" id="SLM49883">
        <property type="protein sequence ID" value="SLM49883"/>
        <property type="gene ID" value="NSJP_3716"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3716"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="219"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="310"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="341" mass="37511" checksum="773F470C19D6246B" modified="2017-06-07" version="1">MDVLSEVLKTVKLDGAIFYTAECSAPWGFRSPPGRIMASYLSPEPKHVIVYHLLTEGRGYAQVEGDGTLLHLDAGDIVVFPQGDPHLLGNGPAVEPIDSSKELQRILSEDLKIARCGGGGEVTRIICGYMTCEPQLSRIFLGGLPPVLKVNIRKDASGQWLENSIRYSVETADTSRPGGETVLAKLSEVLFIETLRRYIAQLPQAESGWLAGVRDQEVGKALALLHRQPAHPWTIATLASEVGTSRSVLAERFRQYLSETPIAYLTRWRLQLGRQMLASTNHSVAQISGDVGYESEPAFNRAFKRAFGLPPARFRSQSRSSRGPADRHAATPDRPASVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB46</accession>
    <name>A0A1W1IB46_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">truA</name>
        <name evidence="9" type="ORF">NSJP_4110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4110"/>
    <dbReference type="EnsemblBacteria" id="SLM50277">
        <property type="protein sequence ID" value="SLM50277"/>
        <property type="gene ID" value="NSJP_4110"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4110"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="7"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="143"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM50277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="246" mass="27528" checksum="3EF4CBFAAFD3D380" modified="2017-06-07" version="1">MATVKLIVEYDGTAYAGWQRQPDQPTIQEALETAVRGLTQIDVSIVGAGRTDAGVHALGQVASFRIDKNWTPREWIKGMNARLPEDIAVRSAGLMPDDFHARYAASGKLYEYRILNRPARSAVDRRYVWHLHKPLDADAMQQAAALLPGSRDFSSFEGSLTDNEDPMCNLQRLSIDRDGEYLLIQAYADRFLKHMVRAMVGTLVEVGLRQRSAEEIPVMLAAKDRTKAGRTAPAHGLFLLHVDYHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB80</accession>
    <name>A0A1W1IB80_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_4140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4140"/>
    <dbReference type="EnsemblBacteria" id="SLM50307">
        <property type="protein sequence ID" value="SLM50307"/>
        <property type="gene ID" value="NSJP_4140"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4140"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="335" mass="37805" checksum="131DBFC9EC8D618D" modified="2017-06-07" version="1">MPCVYPSMHSGAAMRFSRPRWEKKGLIYRPDARVAWMKSHCQLPVADQLDGSRYRVYFASRDELQRSHIGCIEIDLHEPVKVLGSTVQPILSPGPTGHFDEHGVYPSSIVTVGNKKYLYFIGWNRGCRQPLFYASIGLAVSEDGGRSFERLFRSPIMARSEHDPCLVTSPNVFIDNDLWRMTYVSGIRWEESADGGLKSVYHIKYAESRDGISWTRDGTVAIDFASKDETNIARSSVLKFGGAYRMWYSTARLPVRPYRIGYAESDDGTRWTRIDEGVGFDVSDEGFDSEMICYPHVIHHENKLYMFYNGNGFGREGIGLAVADDSEASVAMTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBB5</accession>
    <name>A0A1W1IBB5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50296">
        <property type="protein sequence ID" value="SLM50296"/>
        <property type="gene ID" value="NSJP_4129"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4129"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="328" mass="35592" checksum="F9B03E0203E66D1A" modified="2017-06-07" version="1">MTRVLVTGAGGFLGHALTEDLVRSGHRVRALIRQPALPQDVPGVDTIVGDIRDPRCAGEAARGCDAVVHLAGLVHAADDKSLREADYRSINVDGTRHLLDAAVAGGVSRFLFASSVKVFGETTAGCADERTPPDPQTPYARSKWEAEQAVAASAVPGRFATVSLRLPLVYGRTAKGNLYRMIDAIDRGRFPPLPRVRALRSLLSVKNFVLAVRALLQPKAVARPCYVVTDEVPYSVTDIYDLLRSGLGLPPPSWRVPLPILTVTGLCGDLLQLCVRRPLPLTSATLVKLIGQAWYSSEALMREAGYRPFDRFDAAVPDLIAHYRQSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBC3</accession>
    <name>A0A1W1IBC3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type polysaccharide/polyol phosphate transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_4157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50324">
        <property type="protein sequence ID" value="SLM50324"/>
        <property type="gene ID" value="NSJP_4157"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4157"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10147">
        <property type="entry name" value="Wzt_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029439">
        <property type="entry name" value="Wzt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14524">
        <property type="entry name" value="Wzt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="62"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM50324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="427" mass="46645" checksum="24DAAFAAE78A7F03" modified="2017-06-07" version="1">MTVEAGAPAIRVRQLSKRFEIYRRPADLIRELITRRPRHEVRWALRDVSFELRHGEVVGVMGRNGAGKSTLLKILTGTLERTGGDVEVQGKVTSILELGTGFHPEYTGRENVYMGGLCLGLTNDEIDARIESIIAFSELGEVIDQPFKTYSTGMQARLTFSTVVSADPDILIVDEALSVGDARFQKKCCDKFRSFREAGKTILLVSHSADAITSMCDRAILLENGTVAADGDPSYVTKYYHRMLFGGDEPDAAVPPCDAAPQSGVEPDQVRASGHRCMRYGNGRAAITNLAIHDRDGRPASTVESGSGCTVRFTIIAREDLDDLVAGMLIRDRRGVDLYGTDTLLRGVPVEAVKAGDAVQVVFHLSMWLAGGTYFLTASAARSDGKQYDLLYDGLQFEVTGDRFAYTNSLVNLDVSVEMAPASYSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBC5</accession>
    <name>A0A1W1IBC5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_4139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4139"/>
    <dbReference type="EnsemblBacteria" id="SLM50306">
        <property type="protein sequence ID" value="SLM50306"/>
        <property type="gene ID" value="NSJP_4139"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4139"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="442" mass="50223" checksum="A9CADE259B1F914B" modified="2017-06-07" version="1">MTDVSPVLRGLARGVALLFDLACLPWLVLASLTLRGGQRLLIWGPIPIINNKYWSEAMRRAGWDSRTLMSTYYSSINQRSDYDIYYEDLFKIRWLGSLAEALGAYVAHLYIVRHAKVVHIPFSGGPLGRTVFLWKWEARLYRLAGVRTVVLPYGADIYRYSKVIDPMVRHALLLSYPDAARREARVERSVRYWTEHADAIVMGFTMDGVGRWDVPSGNMVCIDTNNWSQTRRTSEATSDRPVRILHAPNHRGVKGTEYILTAVDRLKTEGLPVELVLAERISNDQVRQLMQEVDILADQLILPGYGLNAIEGMASGLPVVANLDDRAATEIFRRYSFLDECPVVSATPATIAEVLRVLVTNRSLRSELGTAGRAYVEKYHSYATAQYLFGAIYKKFAGEAVDLMNLYHPLKSAYCRERAMVKHPLVDNRIPRRYFENAYEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZT5</accession>
    <name>A0A1W1HZT5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46268">
        <property type="protein sequence ID" value="SLM46268"/>
        <property type="gene ID" value="NSJP_0096"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0096"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="65" mass="7279" checksum="1926ECA0C506625C" modified="2017-06-07" version="1">MTLYYPLKIRPVTLLLARTPTRGWYEVQALGLPRHRSHAPRIPGTGLVDFGCNGFLARREGSDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZV3</accession>
    <name>A0A1W1HZV3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytochrome_C554 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0103"/>
    <dbReference type="EnsemblBacteria" id="SLM46275">
        <property type="protein sequence ID" value="SLM46275"/>
        <property type="gene ID" value="NSJP_0103"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0103"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023155">
        <property type="entry name" value="Cyt_c-552/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13435">
        <property type="entry name" value="Cytochrome_C554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome_C554" evidence="1">
        <location>
            <begin position="59"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="422" mass="46971" checksum="D70CE11B58E04103" modified="2017-06-07" version="1">MAGQSMHRIFRAVAVKKTTLAVVFVALAWTWLGTVEDRTLAQDAKSQASIEKAFPNSNKCKRCHERVFEEWETSPLSRSIHSPAFRATLDAFLASPEGKDKALCFRCHAPHIREFQDHTQLFIDQVKSGDPQLDGVACAQCHLIKQVDRAKHPPEPKYEAPGSKTLYGPYKDFSQNLAHQSMELGLFKKSDLCLNCHQAVPSAANLGKANDLLGNWDQSKAVKSGKECQSCHMPEQTGESANGEKKRTVANHTFPGRIGKLRQEAAKLDVETKIEGDKTTVIVKVQSLVPHNLPTTHPAWASVVLDLVIKGKNLKTVFSDKRIYGRVYHNAKGEKTQFDFEAVKVVEDTVLKPEELRVETFTFPTPKETRTFDVEATLSYAPITGPAPFLQRIEAESSKGTSDPVFQPIEIVTRTENVPIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZZ5</accession>
    <name>A0A1W1HZZ5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0149"/>
    <dbReference type="EnsemblBacteria" id="SLM46321">
        <property type="protein sequence ID" value="SLM46321"/>
        <property type="gene ID" value="NSJP_0149"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0149"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011986331" description="Plastocyanin-like domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="196"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1614" mass="177886" checksum="3AEDB408111E4EFD" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I014</accession>
    <name>A0A1W1I014_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0135"/>
    <dbReference type="EnsemblBacteria" id="SLM46307">
        <property type="protein sequence ID" value="SLM46307"/>
        <property type="gene ID" value="NSJP_0135"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0135"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="59"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="300" mass="33187" checksum="64D6E73AB3746D0B" modified="2017-06-07" version="1">MLETKFKVAFLLTVIAFAALPIMGILRGTSLTPLEDSSSRTESVAEPLEADAKEEPVGEDMVAIPSGPFLRGTTDGGFDEQPQRTIALSAFKIDRHEVTNYQYRQFVTATGHRKAGPPSRYAKSVGKMRGINQPVVYVSWDDAVEYCRWKGKRLPTEAEWEKAMRGGDGRLWPWGNLEQPNGANWGRVNDGHEVSARVGSFPADKSPYGVMDGAGNVMEWVDDWYAETYYRDSPEQDPPSPEYGTYRVMRGGAYTTTGHDVRITSRSKIVPDFRDETIGFRCAISDPKSTGKSDGSGGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I093</accession>
    <name>A0A1W1I093_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46309">
        <property type="protein sequence ID" value="SLM46309"/>
        <property type="gene ID" value="NSJP_0137"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0137"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="117" mass="11840" checksum="222D24F6A856042C" modified="2017-06-07" version="1">MPIQKLVDIVFGMTVMGTVGTLIGFIMGASLMPVAIGLGLLLGGVIGFLGGRRFLVSILIGTVLGGALVWLVAGTDRIWVGAGAGAAMGGFLGVQISMLLDIRAARKHVPEPADPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0C7</accession>
    <name>A0A1W1I0C7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46460">
        <property type="protein sequence ID" value="SLM46460"/>
        <property type="gene ID" value="NSJP_0288"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0288"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="72" mass="7961" checksum="2DA2C329BDD205D2" modified="2017-06-07" version="1">MPRSGYLEGGGLTGSLFGQFLGLLSENVREMRLKITTHPRGKTPCLFGISTDGRPRYAWIRQSMDCGTAEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0J7</accession>
    <name>A0A1W1I0J7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="7">HIU hydrolase</shortName>
            <shortName evidence="7">HIUHase</shortName>
            <ecNumber evidence="7">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hiuH</name>
        <name evidence="9" type="ORF">NSJP_0332</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46504">
        <property type="protein sequence ID" value="SLM46504"/>
        <property type="gene ID" value="NSJP_0332"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0332"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000895">
        <property type="entry name" value="Transthyretin/HIU_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="PTHR10395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00189">
        <property type="entry name" value="TRNSTHYRETIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="SSF49472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TR_THY" evidence="8">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600895-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="114" mass="12423" checksum="935EFDC3B4BB9DF1" modified="2017-06-07" version="1">MSAISTHVLNLVTGLPARNVSVVLESQGSLRTWRKIGDGRTDADGRIEDLVPPGVRIQTGSYRLTFDVASYFRSQNGASFYPEIAIAFGIQDPAQSHHIPLLIGPFGYTTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Q3</accession>
    <name>A0A1W1I0Q3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0385"/>
    <dbReference type="EnsemblBacteria" id="SLM46557">
        <property type="protein sequence ID" value="SLM46557"/>
        <property type="gene ID" value="NSJP_0385"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0385"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="320" mass="34005" checksum="AED33A59D31B47D7" modified="2017-06-07" version="1">MYDVIIIGGSYAGLAAALQLVRARRHVLIVDAGQRRNRFAHGSHGFLGQDGQPPAAIAAKGRSEVLAYPTVTWREALATEARSVSDGFVVRTGSDEHRAKRLILATGVVDELPAISGLADRWGKQVFSCPYCDGYELGMGRLGVLATGVASTRFALLISEWAGVGKTTFFINGAVEPEAEQLAALASRHIEVERGEVVEVAGNEPVLELRLGNGRSSILDGLFLLPHTRLNGPFAEQLGCEVEMGPHGPLYRTDETKETTVAGVFACGDAALTMPSVAFAVADGVRAGKSTHQSLVFGSVKKEETKTQRDSDGALPEPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0T7</accession>
    <name>A0A1W1I0T7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0429"/>
    <dbReference type="EnsemblBacteria" id="SLM46601">
        <property type="protein sequence ID" value="SLM46601"/>
        <property type="gene ID" value="NSJP_0429"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0429"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018641">
        <property type="entry name" value="Trfase_1_rSAM/selenodom_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36529">
        <property type="entry name" value="PTHR36529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09837">
        <property type="entry name" value="DUF2064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04282">
        <property type="entry name" value="glyco_like_cofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="269" mass="30032" checksum="B7498131860F82B4" modified="2017-06-07" version="1">MRVAGRGSPAGVSKPETRSRLLGRPMTNRPSADLALIILTEAPIVGQVKTSLCPPLTQDEAATLHGSFVLDTLERTKVAMDKWKLPFDRYLACAPSSQHVFFKIMEERHRVRLIDQLGADPDARMRETCRAVFDKGHRRVVMLGTDIPTLPLEYYRQAAMLLDEHDLVLGPEQTGGCYLFGLAKRADGLFSDIPWCTDQVFRVTRERAESLGLRVASLPEWRDVDSIDDLTAFIEAGARDASLPKAERQFSSRTAGTLQLLAKRIRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0X4</accession>
    <name>A0A1W1I0X4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46637">
        <property type="protein sequence ID" value="SLM46637"/>
        <property type="gene ID" value="NSJP_0465"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0465"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="73" mass="7328" checksum="8625CA10D9E01610" modified="2017-06-07" version="1">MKDDIFQGVPEGSLVGRRGGLMDPVPACRYGVGGQRSGSFGTLAGGLRSGITGAALSAQEALGHPGTGDRLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I102</accession>
    <name>A0A1W1I102_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46672">
        <property type="protein sequence ID" value="SLM46672"/>
        <property type="gene ID" value="NSJP_0500"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0500"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="72" mass="8312" checksum="81A12976EFD8D620" modified="2017-06-07" version="1">MPEGKKVRIRVRTVTCVYVGDFLIPPMRHRVSDAINEEQRLFINLTDVVINDKDRSEFVAVNKNLIESIAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I124</accession>
    <name>A0A1W1I124_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46569">
        <property type="protein sequence ID" value="SLM46569"/>
        <property type="gene ID" value="NSJP_0397"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0397"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012664270" evidence="1">
        <location>
            <begin position="20"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="99" mass="11012" checksum="F83150AF6E6716E3" modified="2017-06-07" version="1">MQLVIIVLSLLFAACSTLGNPVLDKKPTDWPPPTMTKAQLIQELGPPKSTSTRTIGGKQIEVLLWAYTKSVMFTSRSKILSVEFEGETMVDKVWSQTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I155</accession>
    <name>A0A1W1I155_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Orotate phosphoribosyltransferase (Modular protein)</fullName>
            <ecNumber evidence="1">2.4.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.10" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0542"/>
    <dbReference type="EnsemblBacteria" id="SLM46714">
        <property type="protein sequence ID" value="SLM46714"/>
        <property type="gene ID" value="NSJP_0542"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0542"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="250" mass="27655" checksum="7B6F17A0F5B111FE" modified="2017-06-07" version="1">MSVLTDERALAELVERHRRLYGGPAIDPKLKAIIREGSHTRLTTWDVLHVLQTSQSVFFDTHVEVVSGHHTATYLRFDSIARSPQLIGLLSGDMADWIQQEFERDPIAGIVATSSAAEQLAKGIAEVLRSTMPLRVALTPYSHETGRIGTDIKAGAIKRGERFLALNDVTTRGNCVSKLGTVVTGNGGLLAGMMVFARRDSGQFPLMHELTAQHPFYCATDLDMPQWEPGQCPLCRQHMPLLSWKDIPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1D3</accession>
    <name>A0A1W1I1D3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46794">
        <property type="protein sequence ID" value="SLM46794"/>
        <property type="gene ID" value="NSJP_0622"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0622"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="6"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="110" mass="12477" checksum="C55C65CD070BDBAC" modified="2017-06-07" version="1">MHFTIRPFRRIPLCCPVAYQVEQFEGFGMVWNVTPMGWRFSGDLPLRVGEVCSLTVTLPTHQEIYVAAAIVRWVRAEEYGVETLVIDAESREDLDQFLSEWTAEAPGADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1E0</accession>
    <name>A0A1W1I1E0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46802">
        <property type="protein sequence ID" value="SLM46802"/>
        <property type="gene ID" value="NSJP_0630"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0630"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="63" mass="7061" checksum="9EFDBE7802C6AC12" modified="2017-06-07" version="1">MLPANRAIPRQDECVTLGKTAVRLGGRRDSQEILQCFPSFTPWPTEKLSECQTVCPERLAFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1E1</accession>
    <name>A0A1W1I1E1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0648"/>
    <dbReference type="EnsemblBacteria" id="SLM46820">
        <property type="protein sequence ID" value="SLM46820"/>
        <property type="gene ID" value="NSJP_0648"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0648"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008476">
        <property type="term" value="F:protein-tyrosine sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006478">
        <property type="term" value="P:peptidyl-tyrosine sulfation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026634">
        <property type="entry name" value="TPST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788">
        <property type="entry name" value="PTHR12788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="299" mass="35134" checksum="9C74948399D17EC8" modified="2017-06-07" version="1">MSPTQEDTPLITQPIFVIGCNRSGTTLLFETLSRHPSLWSLYVEAQDVWYKHYPIHAEHGDRVTECPSAAVRNQVQSALYSLAHNKEYLKDRAVWQFVPRKLMQRPIVDAYKTPPIRLVEKTPANCLRIPFLARLFPDAKFIFVIRRGEDAVSSLMEGWKVWSRTDHAAWSFNRWHYLVPPGWQRWIGKELVDICAFQWMEANATAWTDLNEHCQGRYIAVRHEDLLVRPHVEYDTIWKFCELPPSKYFTAQLDSIQRRVYTTGGSAPRPDKWKDLHYTEIQSIRPLLEPLNKQFYPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1L4</accession>
    <name>A0A1W1I1L4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0734"/>
    <dbReference type="EnsemblBacteria" id="SLM46906">
        <property type="protein sequence ID" value="SLM46906"/>
        <property type="gene ID" value="NSJP_0734"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0734"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="490" mass="52891" checksum="B7D1E2616FFD40FF" modified="2017-06-07" version="1">MRYRVSVQSLESRGHVLLATLMLMLILSVLGMTSLYLAGQDRPGIAAMREETVAEQLADSATDLIMTWFHDSSTTPAALREVLIRRQGDPMTGPSFFDAALHSQFAGTADHPDVLLDAGNAGDNNILNGPPSGFVGALRDIGRLTRFKLYGPLRPGLLATMEVTASTIGGRPLARTVQVQLGALSIPPIRSAIQVSGGLGTAQADGESPVRVHWGDQRIAGSLVVKRMEDVAMKTSDAPVTEQPYDSLKQAIDRWTEYWIGGDLTVMLPPPGQSVHPVPSQNVHLQQSPSPGVRLDHWDYEAMKKTALRHGVYYRLDRQGLLHHQDASEGEQGFSPSDLLTSQTVGNHRGLVFVDTMDGEPPRDANMGTLVLDSEYLESVLIVQGHVVLKPQGGGRSFPVLSPGQNGTRVLGTRIPVNLSGIHFRGLLWVGGTVTVEQPTKLFGAVKAGGTVMSVNRGATLEIWYDADLAQGLFRGVPVVYKAPGTWRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1L9</accession>
    <name>A0A1W1I1L9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Propionyl-CoA carboxylase</fullName>
            <ecNumber evidence="4">6.4.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pccB</name>
        <name evidence="4" type="ORF">NSJP_0551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.4.1.3" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0551"/>
    <dbReference type="EnsemblBacteria" id="SLM46723">
        <property type="protein sequence ID" value="SLM46723"/>
        <property type="gene ID" value="NSJP_0551"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0551"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="21"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="277"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="534" mass="58115" checksum="D86B1C040667CB48" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1M3</accession>
    <name>A0A1W1I1M3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Response regulator, CheY-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0720"/>
    <dbReference type="EnsemblBacteria" id="SLM46892">
        <property type="protein sequence ID" value="SLM46892"/>
        <property type="gene ID" value="NSJP_0720"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0720"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="142"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="261" mass="28720" checksum="5E37485037A5DD99" modified="2017-06-07" version="1">MVKLLIIDDDRMNCDLLQAVFARHGYEVHTATNGIEGLALFREHGPRVTILDLRMPGMDGLMTLKEIRAMDPQAPVIILGGGATEIQENQARSLRVTDFLRKGLSLDVLVEGVNRVVQQPMKSVSDSSLVPSAGTATDIGETVLVVDDEQLVRELLVQFLSLRGYRALGVKSATAALSMVDQAPPDLILLDLFLPGMSGVEMMRRLRQKEFGGAVIIITGSHDEEVLEEAWSLHPQEVLTKPVDLERMLSVIQLVLVCREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1X6</accession>
    <name>A0A1W1I1X6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative alcohol dehydrogenase AdhA</fullName>
            <ecNumber evidence="2">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">adhA</name>
        <name evidence="2" type="ORF">NSJP_0820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0820"/>
    <dbReference type="EnsemblBacteria" id="SLM46992">
        <property type="protein sequence ID" value="SLM46992"/>
        <property type="gene ID" value="NSJP_0820"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0820"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd08298">
        <property type="entry name" value="CAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014187">
        <property type="entry name" value="ADH_Zn_typ-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02822">
        <property type="entry name" value="adh_fam_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="333" mass="35327" checksum="5B4C8A9C6EAEE0B3" modified="2017-06-07" version="1">MKAMILNRTAAVESSPLVCADVPLPTIGSQDVLVRIRCCGICRTDLHVIEGELRNPVLPLIPGHQAVGIIEQAGSAVSSRRIGERVGIAWLQGTCGSCEFCRSGRENLCLGARFTGYQVPGGYAGYAAVPASFAYPIPETFSDVEAAPLLCAGIIGYRALRLSAVQPGQRLGLYGFGASAHITIQIARHWGCEVYVCSLKPEHQRLARELGARWVGGAAEPPPVSLHGAIIFAPAGELVPPALRALQRGGTLALAGIHMSAFPPLDYDRDLFGERVIRSVTANTRQDAAELLQEAARIPIRPRSREFPLEEANQALQALKAGTIAGAGVLTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Z2</accession>
    <name>A0A1W1I1Z2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two component, sigma54 specific, transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47015">
        <property type="protein sequence ID" value="SLM47015"/>
        <property type="gene ID" value="NSJP_0843"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0843"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="125" mass="13636" checksum="78A5033B0592D870" modified="2017-06-07" version="1">MTKILVIDDDSRDRELLATVLEERGYEVILADSGGTGLMLCHRRDPDAVVLDLHMPGIDGHHLLRQLQTLHPSLPVVVFSGCGPGEVEQDVLNHGATAFIQKAFSLDQFGLALQEVLPAPSKRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2U8</accession>
    <name>A0A1W1I2U8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidoglycan-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pal</name>
        <name evidence="10" type="ORF">NSJP_1123</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the Pal lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47295">
        <property type="protein sequence ID" value="SLM47295"/>
        <property type="gene ID" value="NSJP_1123"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1123"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02204">
        <property type="entry name" value="Pal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039001">
        <property type="entry name" value="Pal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012393407" description="Peptidoglycan-associated protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="9">
        <location>
            <begin position="104"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="217" mass="23258" checksum="3BC310F6C5C5BFF8" modified="2017-06-07" version="1">MIDRFQTVKLVCLCLCLGMLGTTAGCAKRAVSSAGEQQSPASAKAAPVENIVPDKIVTFPDHQPAPPSAAGGSSVAASRLEQPADSAPHQSSPRPESSTGAAAVGDADPVLTDIFFDLDRYTIRADAHSVLDTNAQLINNLSDKSVVIEGHCDERGTQAYNLVLGEKRAKSAKHYLEDLGVPAGKLKIVSYGEVRPSCHQHEERCWQKNRRAHFTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2U9</accession>
    <name>A0A1W1I2U9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1156"/>
    <dbReference type="EnsemblBacteria" id="SLM47328">
        <property type="protein sequence ID" value="SLM47328"/>
        <property type="gene ID" value="NSJP_1156"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1156"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="246" mass="27832" checksum="D944F33E159998DD" modified="2017-06-07" version="1">MRLTLATYNIHGCIGRDGRYAPERIRDVILELDADVVAIQEIDAPERHGLELAYWLGKESKLRVIAGPTLLERKGHHGNAVLTRCQYDDIRLVDLSRPHREPRGAIDLDLRCSGATIQVIATHLGLQTKERRVQVQWLLERVGQNCVLMGDFNEWWLWGFPLRRIKAAFASSPALPTFPSARPVFALDRIWIKPPASFVSLGVHRTRLSAIASDHLPLKAVVEWPLRETEPVPEEQRSTHAPASEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Y1</accession>
    <name>A0A1W1I2Y1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Blue copper protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47239">
        <property type="protein sequence ID" value="SLM47239"/>
        <property type="gene ID" value="NSJP_1067"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1067"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013320497" evidence="1">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="2">
        <location>
            <begin position="16"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="139" mass="15524" checksum="1BB76EE0BD1CE61C" modified="2017-06-07" version="1">MITARSWMIVAALSGFCWLATGVPVGSQAEQTVEVTIRDFTFLVSKEAPLRLGLPTVIYVRNEDSERHDFGSSMFEGLPTRVEKDGIIVYGRGVEGVMLDPKRDATIRFNMERPGRYTFRCSIHPNMKGELLLLSAEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I344</accession>
    <name>A0A1W1I344_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Histidine kinase</fullName>
            <ecNumber evidence="6">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1081"/>
    <dbReference type="EnsemblBacteria" id="SLM47253">
        <property type="protein sequence ID" value="SLM47253"/>
        <property type="gene ID" value="NSJP_1081"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1081"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="172"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="218"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="294"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="480"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="573" mass="63588" checksum="E58F46EB14B8977C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I351</accession>
    <name>A0A1W1I351_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47309">
        <property type="protein sequence ID" value="SLM47309"/>
        <property type="gene ID" value="NSJP_1137"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1137"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="145" mass="15505" checksum="8FA50FDEF3B74627" modified="2017-06-07" version="1">MRMPDAYGDLDMIIAAGSRNRLRTVFGAVGCLILVAGVWIIAPGESAYAAGGTHAALDTPPGIHTISGTLSMLDVKEGKGTLTTDLDKPVFFRLTRPDLFERLSIGDRVTIQLDEEGRAVKVIEALPAEVHEPPPPPNNLPPPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3B4</accession>
    <name>A0A1W1I3B4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47496">
        <property type="protein sequence ID" value="SLM47496"/>
        <property type="gene ID" value="NSJP_1324"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1324"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="154" mass="15886" checksum="BF1FD31ED7D85571" modified="2017-06-07" version="1">MNCYSSSLTAFPVSFRSKLMTLTMVLAFWVVAVVAPAWSQEATPPPPSSEGGNASSAGIGVLSGLSTLLYLPVKTAFAIGGGVVGGLAYVFSGGNEHAAKSIWTTSMYGTYVITPEHLRGDKPIRFLGVADTGDASTQATTPAMDSAPAVEPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3C9</accession>
    <name>A0A1W1I3C9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized amino acid permease YfnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yfnA</name>
        <name evidence="6" type="ORF">NSJP_1322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1322"/>
    <dbReference type="EnsemblBacteria" id="SLM47494">
        <property type="protein sequence ID" value="SLM47494"/>
        <property type="gene ID" value="NSJP_1322"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1322"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="483" mass="51115" checksum="5B04FD5BCD645C43" modified="2017-06-07" version="1">MIRRLFRTKPIEQILADADHPTHRLKKTLTAWDLTCLGIGAIIGTGIFVLIGTAIVGDAHRPGAGPGIILSFVLSGLTCALAALCYAEMSAMIPVAGSAYTFSYATLGELLAWLTGWNLILEYGVACVAVAIGWSGYFNNLLRLAGIELPHWATHPPGGTEGGVANIPAAIIVLLVTVILVIGIKESARMTGIVVVIKLAVILFFIGIGSTSLDSSNWSPFMPQGFAGVGAAAAIVFFAYIGFDAVSTAAEEATNPKRDVPIGIIGSLTVCTILYIAVATVLTGLVPAGQIDIHAPVAEALQVVGFKWGAAVVAIGAVAGITSVLVVMMLGQIRVFFAMSRDRLLGPWLSVVHPRFGTPHRATILTGVAVAVLSAFIPIGEAADMTNIGTFFAFVLVCIGVIILRHTNPDHPRPFRLPFMPLVPILATIACLWLMWQLPALTWIRFGVWTVIGILIYLGYGLKQSKLAALEPTPSLVCPEKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3D7</accession>
    <name>A0A1W1I3D7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Malto-oligosyltrehalose trehalohydrolase</fullName>
            <shortName evidence="8">MTHase</shortName>
            <ecNumber evidence="3 8">3.2.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-alpha-D-((1-&gt;4)-alpha-D-glucano)trehalose trehalohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 8">Maltooligosyl trehalose trehalohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">treZ</name>
        <name evidence="13" type="ORF">NSJP_1181</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.141" evidence="3 8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1181"/>
    <dbReference type="EnsemblBacteria" id="SLM47353">
        <property type="protein sequence ID" value="SLM47353"/>
        <property type="gene ID" value="NSJP_1181"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1181"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033942">
        <property type="term" value="F:4-alpha-D-(1-&gt;4)-alpha-D-glucanotrehalose trehalohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012768">
        <property type="entry name" value="Trehalose_TreZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044901">
        <property type="entry name" value="Trehalose_TreZ_E-set_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006337">
        <property type="entry name" value="Trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02402">
        <property type="entry name" value="trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="12">
        <location>
            <begin position="110"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="255"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="317"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="386"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM47353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="617" mass="69069" checksum="360B05A2F2A03F47" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3N3</accession>
    <name>A0A1W1I3N3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47616">
        <property type="protein sequence ID" value="SLM47616"/>
        <property type="gene ID" value="NSJP_1444"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1444"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="70" mass="8240" checksum="E730FADB37FCB296" modified="2017-06-07" version="1">MHIHGVPRFLVTSLLIPFVLYLWSRINQTMHSPDAFATPVQRLSFAPQPRLDFTEFSPPLHRIINYSWFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3W9</accession>
    <name>A0A1W1I3W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1534"/>
    <dbReference type="EnsemblBacteria" id="SLM47706">
        <property type="protein sequence ID" value="SLM47706"/>
        <property type="gene ID" value="NSJP_1534"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1534"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="83" mass="9379" checksum="93BF3E9FCA3E8E9B" modified="2017-06-07" version="1">MYRIIFILILLIILYFLIRSAVRELKGRGAPDRLPADKNQMVQDPVCHVFVPRGTAVTEVIGGQTYCFCGRSCADKFQKQMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Y7</accession>
    <name>A0A1W1I3Y7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fbp</name>
        <name evidence="6" type="ORF">NSJP_1371</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1371"/>
    <dbReference type="EnsemblBacteria" id="SLM47543">
        <property type="protein sequence ID" value="SLM47543"/>
        <property type="gene ID" value="NSJP_1371"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1371"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="33"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="121" mass="12592" checksum="BB9B017F79A877B3" modified="2017-06-07" version="1">MEQSTSGGNEVTTSSGLQYLDQVVGTGAVAKAGQTATVHYTGWLQNGTKFDSSVDRGQPFSFPLGAGRVIKGWDEGVQGMKIGGKRRLTIPSNLGYGARGAGGVIPPHATLIFEVELLGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Z9</accession>
    <name>A0A1W1I3Z9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1566"/>
    <dbReference type="EnsemblBacteria" id="SLM47738">
        <property type="protein sequence ID" value="SLM47738"/>
        <property type="gene ID" value="NSJP_1566"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1566"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="212" mass="24332" checksum="44FF1FF952B9A801" modified="2017-06-07" version="1">MKRSESGQVNLTSIFILLGAVIACVWIWKRLDLETQEYVIDQAIPLAFAGILIGVAVWVLVRAVRRRKTKRRRRERLMALFQRETARDKQLEVAFALIEVNEYRTEGLEPVIPALKELFSTTLQRSLGDKQHRIRGMAASHLGVLQDKSIVPLLIKALEDDHAYVRSCAALGLGRLRAAETRDRLVRLMEEDWDQTVRSRAREAVERMRMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I406</accession>
    <name>A0A1W1I406_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Manganese transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mntC</name>
        <name evidence="8" type="ORF">NSJP_1427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1427"/>
    <dbReference type="EnsemblBacteria" id="SLM47599">
        <property type="protein sequence ID" value="SLM47599"/>
        <property type="gene ID" value="NSJP_1427"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1427"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="271" mass="29125" checksum="DB07F1E06509BD55" modified="2017-06-07" version="1">MLELFAYDFMQRSVLAAALVGGLCSVVGVFVVLRGLAFVGAGTAHAAFAGVALGYLIGWSPLALAVLFGLTTVWITGWVEEHGRMKLDVSIGILYTATMALAILFIGLMKTYNAEVYGYLFGNVLSVTQDELRTIIALAIFIIGVMVLFSKELYFIAFDQEMAEASGVPARRMFFLLLSLIALTVVVSLKTVGAILVFAMILIPASTAYQLTHSLSTLTWYSLIIGMSTAVCGVLISALWDIPSGPAIVLLATSVFFLSILFSPKRRRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I425</accession>
    <name>A0A1W1I425_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47725">
        <property type="protein sequence ID" value="SLM47725"/>
        <property type="gene ID" value="NSJP_1553"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1553"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="134" mass="14952" checksum="1B9DAC449D995B8F" modified="2017-06-07" version="1">MGPHRTVVTVRHHTVSSASPMSDSSPAPSPWIQQLREEFRSHLETFYGRLKLAPPYESVEKAIRTLTATLHALPKDEQARVAADPALKWSQFRLAFEASGLSKKHRGIIAGLARDRASVDLSQEYDQLLSLFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I435</accession>
    <name>A0A1W1I435_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transglut_core2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0162 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1563"/>
    <dbReference type="EnsemblBacteria" id="SLM47735">
        <property type="protein sequence ID" value="SLM47735"/>
        <property type="gene ID" value="NSJP_1563"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1563"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglut_core2" evidence="2">
        <location>
            <begin position="107"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="287" mass="32611" checksum="8C09A76F2A5A00D1" modified="2017-06-07" version="1">MVVIPESQIRALIRLLADEDERIVQTISDKLIDIGPSAVPLLQEAEIEQPEMAERIASVLEEIRGGKLEDELLRLVAGPDDQVDLEQGGFLIARYAYPSLDVPIYTRLLDEMAQEVQDRIGPRASGEETVKTLNRYLFTEQGFKGNTKNYYEVENSYLNRVIDRRTGIPISLSVIYLLIGKRLRLPVHGIGMPGHFLVKYESDRYKIFVDCFNGGALLTEKNCQRFLTEAGYGFDEKYLQQSPVRAILSRMTKNLLAIYAKLDDPIRKSRLNRFIEILGCDNREGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I446</accession>
    <name>A0A1W1I446_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47776">
        <property type="protein sequence ID" value="SLM47776"/>
        <property type="gene ID" value="NSJP_1604"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1604"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="364" mass="38819" checksum="BECC2EDE729509DB" modified="2017-06-07" version="1">MRLFPQGLPQSVDRPTAPVRAEACGKSVRLLLCTVATAVCVGCVSTGPDGPKPFDLHLQSYRERLAAEPVLSRQFRACLAQVRDSDPEADDEPITPVRALIRKVRERDPVAGDSLSNLQDLVAGLIQDKGRSLDIVSLKGVVAAARLWQERIDVEEEDLAKGASRFARLLVAYNKAYFGNLRLVEAEPPPGETAGGVRPATSVGFVDRSGRSFLFPGLPFQASLESDAFTAEPGSTATSQRIGADLTRIFIEAFFDAAFEVPAVEGATALQVDWAAERPFPELRPDQSGIPLSGMARVTRDALRVEAVVMTKVGEAVRGGSVAGTGNETLAASLETAAGVTAKKLVEHGGYCYLQVKPPATQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I458</accession>
    <name>A0A1W1I458_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative long-chain fatty acid outer membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_1612</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OmpP1/FadL family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47784">
        <property type="protein sequence ID" value="SLM47784"/>
        <property type="gene ID" value="NSJP_1612"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1612"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005017">
        <property type="entry name" value="OMPP1/FadL/TodX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35093">
        <property type="entry name" value="PTHR35093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03349">
        <property type="entry name" value="Toluene_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="449" mass="47161" checksum="4584D56394A13418" modified="2017-06-07" version="1">MIWTIGIFLSVLLQYSNVAAQALRFQPQGASATGQGNAFVAQADDPSAIHYNPAGLTQVSGLQAYMGTALVGGSIHFTGPTGATTRGDLGGSVAFPPPSHFYMSANLGALGLTGLSAVTAGIAVTSPFGLNTRYPTDGPFNTAVTSATLPLIDIKPAVAYKVTDSLSIGLNADIYTFASFLGEGQAQQQQVSAGTGGIPAGASLEFFGNGTGAGFAASLLYAPMKSAEGLPVLSIGFTYHSQAVLPLNGALLVNGTKAADASTSLVLPQIFSGGLALWPIRTVEREWKLEVDVEYVGWKSARNLDIRLSNGVTVPQPQQWKNVPVVAVGTEYKWLSPEWLHHWEVAARGGYTRTQDPVPDQTFNPATISLTANTISVGGGMLCREGGRFLSVIPCGGESWLLPKAIGVDVAYQAWIYESRTVTGNINPTVNGDYRVSVQVGIVSLRFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I493</accession>
    <name>A0A1W1I493_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47824">
        <property type="protein sequence ID" value="SLM47824"/>
        <property type="gene ID" value="NSJP_1652"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1652"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012393409" evidence="1">
        <location>
            <begin position="23"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="121" mass="13100" checksum="171E615B3855DF11" modified="2017-06-07" version="1">MQTYPWVGIFLFALSVSTPVMAADDAQPSNHPEPAAEGLTQTIVQIGGRFCEYHRKDVEQALRGHEAVQSIEFLNDHGTVLIRYEADGVPSDRLAETAAQAAFGTGCRAWVDQGGPAMPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4B7</accession>
    <name>A0A1W1I4B7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative 3-methyladenine DNA glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1674</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1674"/>
    <dbReference type="EnsemblBacteria" id="SLM47846">
        <property type="protein sequence ID" value="SLM47846"/>
        <property type="gene ID" value="NSJP_1674"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1674"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="PTHR10429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="196" mass="21851" checksum="6C516668F25FFD71" modified="2017-06-07" version="1">MVKNSSFMCNILPRAYFNRPTLTVARSLVGKYLVRENGTGQLAGRIIEVEAYVGPSDKACHASKGRTARTDVLFGSPGVSYVYLIYGMYHCLNVVTDREEFPAAVLIRAIQLDGLLIDGPGRVCRALGIDRTLNRLDMTIGKQLWFEEREKRTGRTPIGAFPRIGVDYAGSWAKKPWRFRLLSGEPALSGRRALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4E5</accession>
    <name>A0A1W1I4E5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acriflavin resistance protein acrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acrB</name>
        <name evidence="3" type="ORF">NSJP_1704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1704"/>
    <dbReference type="EnsemblBacteria" id="SLM47876">
        <property type="protein sequence ID" value="SLM47876"/>
        <property type="gene ID" value="NSJP_1704"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1704"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="875"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="905"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="937"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="979"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1063" mass="116760" checksum="9368040489734A41" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4H5</accession>
    <name>A0A1W1I4H5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">pth</name>
        <name evidence="4" type="ORF">NSJP_1755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1755"/>
    <dbReference type="EnsemblBacteria" id="SLM47927">
        <property type="protein sequence ID" value="SLM47927"/>
        <property type="gene ID" value="NSJP_1755"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1755"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="194" mass="21285" checksum="E76564A7D291A5C3" modified="2017-06-07" version="1">MRLIVGLGNPGASYAHTRHNAGIWVLERAAARWGIRLSRRGTAQRGSGRLGSELIELAGTLDFMNVTGPPLKGLLRHFQLTADDLFLIHDDLDLEPGRLRIKRAGGHGGHNGIKSVVEALGTSEFVRIKIGIGRPAPRQDSADYVLEPVTQEELDVFEPCLERAVDALECVIHRGAEAAMNRFNVRDHQSAIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4V6</accession>
    <name>A0A1W1I4V6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47919">
        <property type="protein sequence ID" value="SLM47919"/>
        <property type="gene ID" value="NSJP_1747"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1747"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="105" mass="11923" checksum="66F9C39C8BA90BD7" modified="2017-06-07" version="1">MNSLTSLFKKDGLVEKHQLEGVDPSDRYFNRAILVNRTTSGYAAKVMYEALTVEGQSHPTIAAAVKELIEKLSRLGFRRLRTRANFKGTKYLAEKETWTDYPDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I544</accession>
    <name>A0A1W1I544_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48105">
        <property type="protein sequence ID" value="SLM48105"/>
        <property type="gene ID" value="NSJP_1933"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1933"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="55" mass="5920" checksum="29114A169F4EE1CF" modified="2017-06-07" version="1">MAMLNEPSEFGQGPKVCILAVILLVALIASYVWLQAFGSAQRNPPRGPVVPISLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I573</accession>
    <name>A0A1W1I573_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48135">
        <property type="protein sequence ID" value="SLM48135"/>
        <property type="gene ID" value="NSJP_1963"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1963"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="13"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="144" mass="15699" checksum="C2ABF07BAFDC006A" modified="2017-06-07" version="1">MSEGIDSFPPSTTILLIDGNKTDRTYWATRIRQDAPDYVVLEAEDGETGLSLCNSRRVDCVVLELDLPDMSGFQVLVQLVPRVRYPRIAVIVLSRLIHTSLAQLARTNGAQAYLTKSRISGDDLIGAIRKALAVVSPGSKDASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5B3</accession>
    <name>A0A1W1I5B3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bacterioferritin</fullName>
            <ecNumber evidence="2">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bfr</name>
        <name evidence="5" type="ORF">NSJP_2036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterioferritin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48208">
        <property type="protein sequence ID" value="SLM48208"/>
        <property type="gene ID" value="NSJP_2036"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2036"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00907">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002024">
        <property type="entry name" value="Bacterioferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002560">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00601">
        <property type="entry name" value="BACFERRITIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00754">
        <property type="entry name" value="bfr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0409">Iron storage</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="4">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR002560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR002560-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="156" mass="17642" checksum="25134A3754DEFDBD" modified="2017-06-07" version="1">MKAKEGVVQYLNDVLRAELTAVHQYLLHAALCKHWGYHRLHGHFEHLAHEEVGHSSLLIDHILYLQGTPDVAKLDAVAAGDDAKSLFESDLAFEREDVGLLCKAVAHCAHVGDYTSRHLLEHMVIDSEEHIDWFEIQLKTIGQVGLERYLSEQVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5B5</accession>
    <name>A0A1W1I5B5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribonuclease G</fullName>
            <ecNumber evidence="8">3.1.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rng</name>
        <name evidence="8" type="ORF">NSJP_2032</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2032"/>
    <dbReference type="EnsemblBacteria" id="SLM48204">
        <property type="protein sequence ID" value="SLM48204"/>
        <property type="gene ID" value="NSJP_2032"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2032"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="39"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="502" mass="57166" checksum="F67B7B142E066E76" modified="2017-06-07" version="1">MGLEIAISVAREETRVAVLDNGVVTDLFGDRAKHKDFVGNIYKGKVAKVLPGMQAAFVDIGLEKAAFMHVSDLSMDAEPGDTLVDTDEDEKDGDDLRPRRESSKPIEQLLSEGQDLTVQISKGPIGTKGPRVTSYVSLPGRYLVFMPNVEHIGVSRRIPRDEERARLKEIMKRLRHPGCGYIVRTVSEGVKEEELRSDVDFLHVLWQDIREKHDQQPAPALLHTDLSLSFRVVRDLFGKKVDRLWIDSREEYEAVRDFVQRFSPEQTSRIHFYDKDESLFDHLGVEQEMARALSRKVWLKSGGYLVIDHTEAMTVIDVNTGRFVGKRDQEETILRNNLEAAKEVAYQIKLRGIGGIIIVDFIDMEREKNRDKVYHALVDAMASDKARTRISRISDLGLIEISRERVREDLLRSLSEPCRYCDGRGYTKSPTTIAYEIFREIRRIGTGAEQQRIVVGAHPSVAGLLQDEERQGLEALERECMAKILVMPDEQLHLEQYDLAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5C4</accession>
    <name>A0A1W1I5C4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48217">
        <property type="protein sequence ID" value="SLM48217"/>
        <property type="gene ID" value="NSJP_2045"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2045"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="96" mass="11017" checksum="BBD675204862202B" modified="2017-06-07" version="1">MANGSVMFSINEHELTYLGTWRFGVDSPRYGRMVLLSIVLNESDKNQLAETAKQQSAAMEVHSMVTTFPSLAESKARLYEVMSYPRVPPYFQNHQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5J1</accession>
    <name>A0A1W1I5J1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48288">
        <property type="protein sequence ID" value="SLM48288"/>
        <property type="gene ID" value="NSJP_2116"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2116"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="60" mass="7386" checksum="E7ED5D40CBC9FE8E" modified="2017-06-07" version="1">MPLWYNLTKSGRHRYYRAHQAGTFHRPIFLEGPPRYGYQSRYQWIRQNRKKRPAGLARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5N7</accession>
    <name>A0A1W1I5N7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48332">
        <property type="protein sequence ID" value="SLM48332"/>
        <property type="gene ID" value="NSJP_2160"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2160"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="432" mass="46086" checksum="40E4E8900CCC6B8E" modified="2017-06-07" version="1">MNADLEKLLGAFATDTLTEEERTRLFTAALADQQLFNVLADEQALKELLADPEVRRRVLQSLRQPKPSASGATLSWFDWAVRPATLGIAGGLSAAVLALVLGIRISQDSVMTASRQPVTEDAPSMATPPSPMIQPTPAAPPKQAESSDAPATPSPPRRHSQAPAMPSGEQHQAERQKKNAVPSSREKRDVEPPAPAQVPAVPATAPGAMSSVPSASARALFYAGRSRRSDQLSTTSNQERDARTSGAFTPQAARPERNIDPLTTRDKTAGASALPKPLGLRYSFVLQETNGSQREVDAATASHSSGLVSLTVETNQDAYVQIWRIEPSSDPELLFPETLTGQMSFTIMEGHRHFIPLSAEARTAGLTALVSRAPLGPLRAQEASLLEAAAPNQTQESITSEGTSDSREHATYVVNQNSAESARVSVSVLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6A4</accession>
    <name>A0A1W1I6A4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="11">RNAP subunit alpha</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">rpoA</name>
        <name evidence="13" type="ORF">NSJP_2365</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2365"/>
    <dbReference type="EnsemblBacteria" id="SLM48537">
        <property type="protein sequence ID" value="SLM48537"/>
        <property type="gene ID" value="NSJP_2365"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2365"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="12">
        <location>
            <begin position="25"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="11">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="11">
        <location>
            <begin position="251"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM48537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="333" mass="36505" checksum="1CBC2177AEE06A09" modified="2017-06-07" version="1">MIKAMKDFQIPLRVEVDKETMSPTFGRFSTEAFERGFGTTVGNALRRVLLSSLTGAAVTTVKIEGVLHEFSTIPGVTEDVTSIILNVKGLRLALHTDKPKTIRLKKKGPGEAKGSDIVHDADITILTPNLHIATLDKDATLDMEMTVKHGRGYVPAERNKEEGLPIGVIAIDSIFSPIKRVNFQVENARVGRMTDYDKLTLEVWTDGTISPRDALSTAAGILRDHVDIFINPEARVEGRGELAGEDAQREINKNLFRSVNELELSVRAANCLKNANIKTIADLVQKTEAEMLKTKNFGKKSLNEIKEILTEMGLGLGVKLDALPSNGNPKPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6C0</accession>
    <name>A0A1W1I6C0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48383">
        <property type="protein sequence ID" value="SLM48383"/>
        <property type="gene ID" value="NSJP_2211"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2211"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="185" mass="20477" checksum="8BFEE64D9FEDBF9A" modified="2017-06-07" version="1">MGQRIGSQDNPASHSLLHMRLAWVHAGISIRCLRMMTFYGALLGYLCSQTHLLSAACAEETEHEPANSRTPAQEGIRKYRELESVVDGPILLSAVDIDPAGQFHGQYFVFGKVGHQAFGETLTTYPADSSVYLRATPSPLQGIQLRQLCHVMGESRMTLRETFGHGFSRYDEPVGSKPTRRGVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6I6</accession>
    <name>A0A1W1I6I6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">purF</name>
        <name evidence="11" type="ORF">NSJP_2450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2450"/>
    <dbReference type="EnsemblBacteria" id="SLM48622">
        <property type="protein sequence ID" value="SLM48622"/>
        <property type="gene ID" value="NSJP_2450"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2450"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="17"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="476" mass="52076" checksum="29DE5EAB05969AD4" modified="2017-06-07" version="1">MIKELPLISPDKFHDECAVFGVYGHEEAANLTYLGLYALQHRGQEASGIVSGDGDQFFVQKGMGLVADIYNKSVLESLPGYMAIGHNRYSTAGGQDLKNVQPLIVNFAFGNLALAHNGNLINAQVLRHELEAYGAIFQSTSDSEVIIHLIAHSRASTFLARVIDALSQVRGAFSVALMTDNGLIAARDPHGLRPLCIGRLRSSWIVASETCAFDLLDAEYVREIEPGELIVINDQGLESHHPFPQADPAMCVFEYVYFARPDSRIYGANAVYGIRKALGRQLAQESWVPADIVIPVPDSGVPAALGYAEGGGIRFETGLIRNHYVGRTFIEPEQSIRHFGVKVKLNAVPEVLADKRVVVVDDSLVRGTTSRKIVKMIRQAGAKEVHVRISSPPIISPCFYGIDTPTKKELIASSHSIEEIRKYITADSLAYLSLEGMLKSAPGSPTQYCNACFTEKYPISFTRAEELQLGLFEPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6I8</accession>
    <name>A0A1W1I6I8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PHB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2281</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48453">
        <property type="protein sequence ID" value="SLM48453"/>
        <property type="gene ID" value="NSJP_2281"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2281"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013026317" description="PHB domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="27"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="278" mass="31005" checksum="159364A94A03D50C" modified="2017-06-07" version="1">MRGPVTRVLGAVAVCGAMAVLAGCAAVEAGHEGVFVEQPWFFGHGGVDPVPSKTGRVWIAPTTKVIDVDVRPIQYSEHFDIISAENAPVSFDAFMIANVVEGRSPELISRYGPTWYLNNVKEAFRTFVREEVQKYPLFQLTTDPTTRTKLQEAIAREVQIKLIEKQNIPIRLNRVVVGSILPPKGVVEQTTQTIVQEQRKITMVEFQKAEEAREKAEKQRGIADRAYRESLGLTAPEFVDLRRIEVQKEIVQHAPSSLTVIMGLERFGINMPPLAAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6L6</accession>
    <name>A0A1W1I6L6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative TPR repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_2468</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2468"/>
    <dbReference type="EnsemblBacteria" id="SLM48640">
        <property type="protein sequence ID" value="SLM48640"/>
        <property type="gene ID" value="NSJP_2468"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2468"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039568">
        <property type="entry name" value="Peptidase_MA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13485">
        <property type="entry name" value="Peptidase_MA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_MA_2" evidence="4">
        <location>
            <begin position="333"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="476" mass="53003" checksum="0384526F0AE53EE8" modified="2017-06-07" version="1">MYRRNISHLLYKVALVVALIIIYGAWFKPTYLQRPPGQTRDAQEAETKAPPETLRPAEAVEPPPKQTRLIDHSVVPRSKHQDFLAAIRDDLEKGDLAAATSKLDNLSTSTTNDPAVRPYLAVLWNNVGIEQEKSSGTKESVQTFKRAASLDPKNPVIQLNLAHAYWELRDPAMTVEFLDRLIALAPDEPFPHLAMAELLQERDRLKEAAQHLDQATERAAKDPAVQSYLRTVTAKVRKTDQAEEQLTSRESAHFIVKFDGQADHTTWTTAQDILEEAYREIGQRLGHFPSKPIVVVLQAETAFQSATGSPVWADGLFDPVLGRIQVPSQGALTDRAWLTKVLRHEFAHAVLHDMQGHSGSAIPTWLNEGLAMQLAGEHWSEIQPVKHQEVALIPLTALEGGWSNLTPEAASVAYLEANSAVHYMIDRYGLHGVNQLLGHLKARQSLSAAMQSQLSLSYEQFQSRWADQFKGELAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6V2</accession>
    <name>A0A1W1I6V2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2579"/>
    <dbReference type="EnsemblBacteria" id="SLM48746">
        <property type="protein sequence ID" value="SLM48746"/>
        <property type="gene ID" value="NSJP_2579"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2579"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="258" mass="29253" checksum="C6C815EB76BEC1F4" modified="2017-06-07" version="1">MTDQERVRIFDSQGEAYKQAFQVFLDHTDQKRNAKGWLQQVVDRLPARKVFIDAGAGNGELARTFAPAFERTIAIEPNAYLLKQLQQAVPLAEAIGQSIMTARPPAPGDLVLCSHTFYYIPAEDWFAHLERLVSWMSPTGVTIVVLQHRESGCMNMLHHFLGHRFELRRTAETFRTKHGDRYDVVTTLDHAHVTTPDLARTYAVAEFMLNLLDMKHAPARRDVEAYLQAHFASAEGGYRIPVHQDFLEIRAKTPAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I788</accession>
    <name>A0A1W1I788_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48908">
        <property type="protein sequence ID" value="SLM48908"/>
        <property type="gene ID" value="NSJP_2741"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2741"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="92" mass="10004" checksum="683C8ECF257A887B" modified="2017-06-07" version="1">MVKVLVFGLTLRDALGEHEIEVDCPGPTTVKKLVEANLDRLGPVAEFIASREVLIAVNKKVSTEDSAVKDGDIVKLSHQSRTSYDGTRDIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7B8</accession>
    <name>A0A1W1I7B8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Insertion element ISR1 uncharacterized 10 kDa protein A3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2536"/>
    <dbReference type="EnsemblBacteria" id="SLM48703">
        <property type="protein sequence ID" value="SLM48703"/>
        <property type="gene ID" value="NSJP_2536"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2536"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="88" mass="10068" checksum="D2D1C08776BCA227" modified="2017-06-07" version="1">MTRKRHTEEQIIAVLKDAQAGTGVQELCRKHGISDATFYQWRAKYAGLEVSAVKTLRQLEDENRRLKQMVADQALDIQALKAINAKNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7D8</accession>
    <name>A0A1W1I7D8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2728"/>
    <dbReference type="EnsemblBacteria" id="SLM48895">
        <property type="protein sequence ID" value="SLM48895"/>
        <property type="gene ID" value="NSJP_2728"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2728"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005883">
        <property type="entry name" value="PilM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007813">
        <property type="entry name" value="PilN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11104">
        <property type="entry name" value="PilM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05137">
        <property type="entry name" value="PilN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="524" mass="56876" checksum="AE513F3C2B3B9B87" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7H3</accession>
    <name>A0A1W1I7H3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative iron acquisition-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2704"/>
    <dbReference type="EnsemblBacteria" id="SLM48871">
        <property type="protein sequence ID" value="SLM48871"/>
        <property type="gene ID" value="NSJP_2704"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2704"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032623">
        <property type="entry name" value="FecR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16220">
        <property type="entry name" value="DUF4880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4880" evidence="3">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="124"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="333" mass="36605" checksum="281920EBA822F75F" modified="2017-06-07" version="1">MADQIDQDNTGDTHASGVSDIAQEWIVRLVSGRITAEELRLLKAWLAEQPSHQRAFDRERTVWQQLDQLQHVSAALLEEDRRTPEPPARLRRHGRRYALVGGLAAACLAFIVLYQDIRAFLLADHHTGVGHVQVVTLPDGGLAHLNSDTAIAVSYTDHERRVDLLRGEALFEVVSNPQRPFRVAAQDGVTQAVGTAFVVRADPQQTRITVVEGTVGVFAGTDVQTGQQVIVRKDQHTVYRPGETPQDARPADGGSAKAWSQGIIAIEGQPFAQAMAELDRYRPGRIVVLADRSRTKPVSGRFKIQKVDDAISALAKLQGLQVVHVAGYFVFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7M1</accession>
    <name>A0A1W1I7M1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">LexA repressor</fullName>
            <ecNumber evidence="14">3.4.21.88</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">lexA</name>
        <name evidence="14" type="ORF">NSJP_2839</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the peptidase S24 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="14"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2839"/>
    <dbReference type="EnsemblBacteria" id="SLM49006">
        <property type="protein sequence ID" value="SLM49006"/>
        <property type="gene ID" value="NSJP_2839"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2839"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="11" id="KW-0742">SOS response</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="13">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM49006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="181" mass="19783" checksum="C7FEC37F4A4795A4" modified="2017-06-07" version="1">MKPSELKHMREQLGLTQQQLADALQTTRVSVARYEAGMRRIPGMVKVAIERLNRSSEIPMAGMVAAGAPIEPVPQAELIEVPLSMLRGGDTFALRVKGESMKDDGILPGDIVVVHKQETAKNGQTVVALVNHEATIKTYYKKDTHIELHPANSAMEPIFVQPSDAFHIEGIVIGVIRHCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7X0</accession>
    <name>A0A1W1I7X0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49100">
        <property type="protein sequence ID" value="SLM49100"/>
        <property type="gene ID" value="NSJP_2933"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2933"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="28" mass="3159" checksum="D80B880FC33B6637" modified="2017-06-07" version="1">MDISMIFFLANALMAGLIYIVVGIIWQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Z9</accession>
    <name>A0A1W1I7Z9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">coaX</name>
        <name evidence="7" type="ORF">NSJP_2970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2970"/>
    <dbReference type="EnsemblBacteria" id="SLM49137">
        <property type="protein sequence ID" value="SLM49137"/>
        <property type="gene ID" value="NSJP_2970"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2970"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="265" mass="28387" checksum="2733F5529C9BA75B" modified="2017-06-07" version="1">MAMLLVVDIGNTNIVWGVYDGPRLIAHWRLATDSKKTSDEYGILFTSLLRSVGTPPERMTGAIISSVVPALTGTFEELIGVYFRQRALVVGTEMDLGLTLRYANPREIGSDRLVNAAAAYHQYRQDLIVVDFGTATTFCAITAGAEYLGGVIAPGLSISAEALFTRAAKLSKVELTKPKSVIGTDTTASIQAGLLFGYAGLVDALVRRIEQEIGRQTLVIATGGLSAIIAPETVSIHKVEPLLTLQGLRLLYDRARGGPLPSIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I858</accession>
    <name>A0A1W1I858_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49212">
        <property type="protein sequence ID" value="SLM49212"/>
        <property type="gene ID" value="NSJP_3045"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3045"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012935628" evidence="1">
        <location>
            <begin position="25"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="347" mass="36667" checksum="A7B971D8BDE499DF" modified="2017-06-07" version="1">MRYLRYITATAWSAILALGGCSGAFEPVKIGSYDMPASQASSSAPSASVPARIYVANESSNDVSVIDANTFQSVGTIPALNHSTHDLAVSRDGRRLYATNLASGRVSVIDTAKRETIASIYTGERCHVVALSNDDGQLWVANIGENTISIVDTVTFRILGTIPVGKGPTGLTFSHDGRFAFVSSQGEKTVGVIDTASHQIVKTIPVGANPHFLVVSRDGHIWGVNTGQNDVYVLDPESHEKVGTFTVGDKPQQIAFAYKGTAGPLAYITVGSQNKVVGLGGDPKELKVVDEIAVGEGPNGIWSNPEGTRLFVAHDKGNEIRVIDTGTGQTLATVPVGRKPIRVVVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I871</accession>
    <name>A0A1W1I871_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Response regulator with HD domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2954"/>
    <dbReference type="EnsemblBacteria" id="SLM49121">
        <property type="protein sequence ID" value="SLM49121"/>
        <property type="gene ID" value="NSJP_2954"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2954"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="15"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="180"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="364" mass="39189" checksum="3105739C86121C3C" modified="2017-06-07" version="1">MSSSTATLSAETKPTVLIVDDEAAPRAALTQTLRQNFNILTADNARTAMAVLNDHGVDLVTLDLRLPDGSGADLLTEIKRAHAEVEVIMVTAFGSLQSAMDCIRHGAAGFLLKPFNTSELLTISLQTAQKKQRLDRLRTLLAEDSALWGPEPGCSAAWRKLATAYAAPHNTDGAVLQPAQIGETASLIQLLSDLLEARDRYLVNHGNRVSFYASLTANRLQLSLPEQNILSLGALAHDLDLIQAADGQALQHESPGNGHRTDLGARIGRALGLPIDAVQIIALHHERWDGTGHPFGLQGERIPLLARIVSLAQTFDELTAERPGASPLTVKAAIDEIERQGGTAFDPDLTELFCKIIREQPPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8A6</accession>
    <name>A0A1W1I8A6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SF3 helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3063"/>
    <dbReference type="EnsemblBacteria" id="SLM49230">
        <property type="protein sequence ID" value="SLM49230"/>
        <property type="gene ID" value="NSJP_3063"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3063"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006500">
        <property type="entry name" value="DNA_primase_phage/plasmid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045455">
        <property type="entry name" value="DUF5906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014015">
        <property type="entry name" value="Helicase_SF3_DNA-vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19263">
        <property type="entry name" value="DUF5906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01613">
        <property type="entry name" value="primase_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51206">
        <property type="entry name" value="SF3_HELICASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3 helicase" evidence="2">
        <location>
            <begin position="185"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="485" mass="54151" checksum="E3857BDA7F37BBBA" modified="2017-06-07" version="1">MTSIRNDTENRAGVETGAPLQSRPLTAADWADEYLTARGLVTVAGLWLRKHRGEWLRYNGAYYESLTPEALEADVTTYFNGTLYRDRVNKAFVSGIIHQLTARCLMPDIDLPAEYHGGAWNPVRDAGIVVLKNGIVRLASVGHLPDLQAHSCQLVTRCALPFNYDPAATCPAWLKFLEHILPDDATRTLLQQIFGYCLTFDMKHQKFFLFEGTGGNGKSVVTRILRRVVGAQNTSSLPLNRFGDKHGLVGTYGKLVNVTGELREKDTVAEDLLKQATGGDAMYFEPKYKTSFTAPFTAKIILCTNERPTFTDRSNGLWRRLVVLPFPVSIPPEEQDPELETRLSLELPGVLNWAIQGAVSLNNAGRFIEPPQSKAAGEEFRDQANHERAFLKERCCLEKHARIGAQDLYDAYRLDAQRGGYKPLSRTKFRKEVLSLSGVKEDRLRKADGTRPHIFHGITTNHRGPIASRSSWLSEVGPDRGQSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8B8</accession>
    <name>A0A1W1I8B8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49246">
        <property type="protein sequence ID" value="SLM49246"/>
        <property type="gene ID" value="NSJP_3079"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3079"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="118" mass="12794" checksum="34A49F71B5B8B212" modified="2017-06-07" version="1">MGPDPASLTPSPRVPRLLIVENNFSRAEPLMSTIGDRRLDVDYDVCTTAFGAVRKLEATPCQLIISAAAMAESDDALLLKRAQAWRHACPLWSPRPAMSENLRDGPYSGAPSISSPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8G1</accession>
    <name>A0A1W1I8G1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49312">
        <property type="protein sequence ID" value="SLM49312"/>
        <property type="gene ID" value="NSJP_3145"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3145"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="SSF117281"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012076991" evidence="2">
        <location>
            <begin position="22"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="349" mass="37905" checksum="BEE0E9E938CD81B9" modified="2017-06-07" version="1">MQALLLMFLMSFLSILSPAQAQTTGKWVKGAPFPQPSEELVGVSSGGKFYVLGGLGPGWIPQGLVYEYEPTIDKWTKRKAMALPSHHIAITELDGKLYVFGGFVPPHSGPPAWVPINNAWEYDPTTDRWKALAPMPSKRGSAVAASVNGKIYVIGGAAPHPGSQETSLQPGRPHRSVSTVEEYDPKNDSWSVRSSMPTARNHAAVGAVNSKIYVIGGRLGSAFIFTASNTNVVEEYDPATDQWGLVKARMPTARSGGAWMVYRDRIYVAGGEHQDEHLMAAFRALEAYDPATNSWEDLPKMPMPRHGLAGAVVGDRLYLASGDIQSAGITGMHVVTDAHDIFEFSNRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8I4</accession>
    <name>A0A1W1I8I4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PepSY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3149"/>
    <dbReference type="EnsemblBacteria" id="SLM49316">
        <property type="protein sequence ID" value="SLM49316"/>
        <property type="gene ID" value="NSJP_3149"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3149"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005625">
        <property type="entry name" value="PepSY-ass_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34219">
        <property type="entry name" value="PTHR34219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03929">
        <property type="entry name" value="PepSY_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="2">
        <location>
            <begin position="282"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="409" mass="45121" checksum="A60B0C2F9B01C488" modified="2017-06-07" version="1">MKSEAGVSPVNPPKGGMIETASRTRNQANAWRTRWLRVHLWLGLSVGALLVIVGLTGSVLVFMNEFDAWLNPALLTAVPSDSRSIQRPLNEIIAAAERMVEPESRILAVMGQHGREGVFSISYMQPSLAQRRVFVDPYTATVTGTREFGTHEVVPAYLIEAVFQLHFTLLSGETGQTIVAIGALLLLVSIATGFILWWPLTGKWRQAFTIRRPATAVRVTFDLHKVFSLYPSLVLGVVLLSGVSMNLHDAFVQVIQWLSPGTRGASARLLSSPSRGRLPIGVVKAWDIATSRYSGGNLYGIFPPESLTGVYLVAFRQVPELSAFWSERWIVIDQYSGAILEARAPDMRRTAGESFLDWQWPLHSGQAFGWPGRLAVFAAGLACPVIFATGVLMWSRKRRSRRGRIANDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8J8</accession>
    <name>A0A1W1I8J8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Helicase (N-terminal)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3084"/>
    <dbReference type="EnsemblBacteria" id="SLM49251">
        <property type="protein sequence ID" value="SLM49251"/>
        <property type="gene ID" value="NSJP_3084"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3084"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="131"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="356" mass="39887" checksum="4E572FF16FF84D94" modified="2017-06-07" version="1">MTTDELEKLLAQQPMALLHRLARGRIHRHFRVGKRRLIDLLIRHSAENRAGFESDVMALIGERPERPATPPQAAPAPRASSHAKTQHAPRQKSHHHEPESHEPSVSLPEWLSGIGVPPPQPFVPDAWQVEAVERLQQTDVIVSVPTGSGKTYVAVEAARRAIEENRTVIYTSPLKALSNTKFTEFSRIFGADRVGILTGDRRDNGQAPLLIMTTEILRNLLYDAAGGEIDLRLDTLGLVIMDESQYIADPERGVVWEETIIFCPSQARLLLLSASIGNPQDIADWLTSIRPVPCHLIRHSKRTVPLRAGYLHPDGKLTPLFRTIGIPHGHAGHWHPEAKRLFARYEEETMPSGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8L7</accession>
    <name>A0A1W1I8L7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 14" type="primary">lon</name>
        <name evidence="14" type="ORF">NSJP_3173</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3173"/>
    <dbReference type="EnsemblBacteria" id="SLM49340">
        <property type="protein sequence ID" value="SLM49340"/>
        <property type="gene ID" value="NSJP_3173"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3173"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="13">
        <location>
            <begin position="10"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="12">
        <location>
            <begin position="597"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="774"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="684"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="727"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <begin position="357"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM49340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="800" mass="88624" checksum="9776FB4AE030C8DF" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8R3</accession>
    <name>A0A1W1I8R3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
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            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="SLM49183"/>
        <property type="gene ID" value="NSJP_3016"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3016"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012212949" evidence="1">
        <location>
            <begin position="34"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="397" mass="41860" checksum="3D1B51F4225CBA39" modified="2017-06-07" version="1">MRFHQTPSRLRQLCMAVAWATVASGLTVAVNFADDPPPVINEPSPTVEATPPIALPNEPPAGDVQERGLAPRVLQPGLEFKQMTPSVPPNPPAFGTLPGEFAIRSYLQSTPFTARDGGHHSIDAVITVPSVLGPNQRFRLASVQPDFTTIQTSGGYYVSAVGGLGGPPNATQPVQTELQTPQSDIALFRVDGPSAAGTYTMKTYDGHFLTALGGGGKANDAFHTDATKASTWEYYYFLKCGDLGSGYQYAIRPTGTGMVPGKGDFVSYLTALGGGGRTSQAMTAFSGLQVGSRFKLIKQNDGTYALQTSSGNYVTAVNGGGLASGDNLHTDAHQVQAWEKFKIVEQPPNCSYTIQTVSGFYLAVGPGSSTISTRISDPNAAPSIGYNAKFELIMIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8T0</accession>
    <name>A0A1W1I8T0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
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            <taxon>Nitrospira</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49331">
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        <property type="gene ID" value="NSJP_3164"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3164"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="4"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="60" mass="7227" checksum="9EB2B0A5D3F7DD09" modified="2017-06-07" version="1">MRRLLTISEASEYLGISKLTLYDWVCCRKISFVKVGRLLKFRQEHLDKWIDEHTINQRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8T8</accession>
    <name>A0A1W1I8T8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49410">
        <property type="protein sequence ID" value="SLM49410"/>
        <property type="gene ID" value="NSJP_3243"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3243"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012686951" evidence="1">
        <location>
            <begin position="20"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="144" mass="15835" checksum="CF99A883488D216C" modified="2017-06-07" version="1">MMRVVLLLLLAVLTGCAHHDLDALRASKPDLMQEVVGPYDGLSKCAKERFDQDRSDNLTLSENPNKGINRLAMLRNRSGFLSKRGQDALFEFTFVRQSAKSTLVEFRSVSSTNQTDPAWRAIAECSASLRIEPPPSPSAALGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8V5</accession>
    <name>A0A1W1I8V5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49415">
        <property type="protein sequence ID" value="SLM49415"/>
        <property type="gene ID" value="NSJP_3248"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3248"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018841">
        <property type="entry name" value="DUF2442"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10387">
        <property type="entry name" value="DUF2442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="80" mass="8843" checksum="D1BD7F6D485AB655" modified="2017-06-07" version="1">MSALAVKLEPLAVEVTFTDSMLRVVLADGRKVSSPLAWFPQLLNATPEQRRKWRLIGGGVGIHWETVDEDISVESLLAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I919</accession>
    <name>A0A1W1I919_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3325"/>
    <dbReference type="EnsemblBacteria" id="SLM49492">
        <property type="protein sequence ID" value="SLM49492"/>
        <property type="gene ID" value="NSJP_3325"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3325"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="59"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="338" mass="37307" checksum="834B457DFFEEAF20" modified="2017-06-07" version="1">MDSIPFSGQPMPARFLIGQAVRVFRPVQTAWVALTLFFASPIIMPAALAQDDPPPLRVVTYNLLHDGAASGFIEGDTHLEDRLEMVIRELKALDPDIVGLQEASDSRTHGNIAERLAQALGFHVVFAPATEHIFRLPPLDWAVVGAMGFKEGSAILSRFPIVDSEVTDLPRCRRWIEPRILLRAEIATERGPLQVYSTHVARGDECQMRRVGELVRERGWLGLSLLMGDFNTPETSQILTALRLEAGFVDTFRVANPDAPGPTVWQRIDVEAPTASTRVDFILYLPGSASSAVVRSSRVILDRPGRLPDGRALWPSDHYGVLAEIDIQPLIRQGAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I922</accession>
    <name>A0A1W1I922_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49514">
        <property type="protein sequence ID" value="SLM49514"/>
        <property type="gene ID" value="NSJP_3347"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3347"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="177" mass="18904" checksum="AC82D5121ABFF8B2" modified="2017-06-07" version="1">MKDAGWRGSCTLFELHVILYSGSIEAVSRTIDDKNMMKSLLIFASTCCSALLLWSAVAASDLDRSMVIGGHIVPLGPETFGKRSGLIGNTVQPVPDQGAASSSTQVFRDIPSISGSYSIGGQMFLPYVGAGFGNGYATDLDRSLHRLPTISSDQGLHNQFGQSVAPNEFQMGIRIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I930</accession>
    <name>A0A1W1I930_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3360"/>
    <dbReference type="EnsemblBacteria" id="SLM49527">
        <property type="protein sequence ID" value="SLM49527"/>
        <property type="gene ID" value="NSJP_3360"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3360"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010428">
        <property type="entry name" value="Zincin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038555">
        <property type="entry name" value="Zincin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06262">
        <property type="entry name" value="Zincin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="127" mass="14195" checksum="C56D72AEA34B479C" modified="2017-06-07" version="1">MGPRGSGQISPEAFDRLVKEALRDLPARYAELVEEVSVVVEEEPPVEVLADLDLDSEDDLLGLYQGLPLSEESFFQPGGQQPPRISIYRGPILRLCTTPEEVKQEIRDTVVHELGHHVGLDDDEMPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I956</accession>
    <name>A0A1W1I956_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Formate hydrogenlyase, small subunit</fullName>
            <ecNumber evidence="3">1.12.7.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.12.7.2" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3390"/>
    <dbReference type="EnsemblBacteria" id="SLM49557">
        <property type="protein sequence ID" value="SLM49557"/>
        <property type="gene ID" value="NSJP_3390"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3390"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="53"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="169" mass="18692" checksum="C3274217412132DF" modified="2017-06-07" version="1">MFRILKKSLKTGVVTGRHPDGREPVEEPTADAREKALPFRRSLTIREVDTGSCNACEMEMNALTNPVYDIERFGIHIAASPRHADALVVTGPVTVNMERPLKNAYKQTADPKLVIALGDCAINCGLFKGSYAVTGPVERHVPVDVRIPGCPPRPEAIIQVLQDLRRRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I959</accession>
    <name>A0A1W1I959_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49471">
        <property type="protein sequence ID" value="SLM49471"/>
        <property type="gene ID" value="NSJP_3304"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3304"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="105" mass="12244" checksum="EC98949B8B7E39C0" modified="2017-06-07" version="1">MAHPVASFCAILMILTLSTGCPLTLEQRWEWFDSERRQEIGVKTKDYYLDEWGPPAKRTTTADGDIVWTWEQRAYGGAQGWRKTLIFTPDGVLKAFSRDYWPKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9C0</accession>
    <name>A0A1W1I9C0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">hflX</name>
        <name evidence="8" type="ORF">NSJP_3423</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3423"/>
    <dbReference type="EnsemblBacteria" id="SLM49590">
        <property type="protein sequence ID" value="SLM49590"/>
        <property type="gene ID" value="NSJP_3423"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3423"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="7">
        <location>
            <begin position="367"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="551" mass="60909" checksum="5A6489565411E4E6" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9J6</accession>
    <name>A0A1W1I9J6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49655">
        <property type="protein sequence ID" value="SLM49655"/>
        <property type="gene ID" value="NSJP_3488"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3488"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="73" mass="8179" checksum="30F823BEA9652E73" modified="2017-06-07" version="1">MGNESFTYRDFIAPELDSIPADAAVAPIQSREGVSHERTSTQSDAAGRHISDRFGSGDRRNRSRRYGNRRDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9K9</accession>
    <name>A0A1W1I9K9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipopolysaccharide export system permease protein LptF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_3513</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3513"/>
    <dbReference type="EnsemblBacteria" id="SLM49680">
        <property type="protein sequence ID" value="SLM49680"/>
        <property type="gene ID" value="NSJP_3513"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3513"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030922">
        <property type="entry name" value="LptF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04407">
        <property type="entry name" value="LptF_YjgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM49680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="363" mass="40343" checksum="E1A2E6B34870FDC2" modified="2017-06-07" version="1">MLLSKLLDRYIFTELLSPFLVSLGALCFVMLTRELLRLVELLVSKGVGLLAVLKVFANLLPSFLVLTLPIAGIIASITAFGRLSFDKELVAMRAAGLSLLRLARPVFLFAFLVFVLTLWLAQWGQPWSSTNLKKVALNLLRDQLVLALERGTFNEPIPKMMIYVSDLGDDASTTGIFVSDERNPDDPRVIVARGYRVFVDMKTSQVALQLQDGVIHSQPDTIDEYQQVGFSSYDLKLSLNQSGYASTEERPSYETIMAQLRESQGRDPSARRRLMEYYKDLAFPTASLVFCILGVPVGIVSKRSGRIGGFAVGVLVVIIYYVLNVGCEFLVTTATLSPFAGAWLPNGIFGLVTVLWFYKMSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9M5</accession>
    <name>A0A1W1I9M5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3525"/>
    <dbReference type="EnsemblBacteria" id="SLM49692">
        <property type="protein sequence ID" value="SLM49692"/>
        <property type="gene ID" value="NSJP_3525"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3525"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="237"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="295"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="351"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="624" mass="66571" checksum="9A4D65CD82AD548F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9R8</accession>
    <name>A0A1W1I9R8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49619">
        <property type="protein sequence ID" value="SLM49619"/>
        <property type="gene ID" value="NSJP_3452"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3452"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="459" mass="49943" checksum="D3AD765C3F653AC5" modified="2017-06-07" version="1">MLINIAIFAISFVMVGSLAVFHPVNEWVCSVKRLPVVSLLLIGLFTSVLLTAQSQATLSVDAIDESRVIRICLLIVLCLVSWVIFSVRGFPFSRCCAALTMMFFFSLFAMSSYIYSVNPLLSLWKGFEVFAAASVFLAIAVSLNTFDDIDGALQVLWLILLFLVLTALVGGVLQPKLAFVRQTFGRGSQAYEYWGQFPRINPNSLTQFGAMVGVGGLVAFLYGRGIGVLSSLCLLGLGALTIYLGHSRTSLLGFLLAAVAIFWFGKKRVLGLMMISAAGLVALAAYTYVEAYVLRGQSKAVFVSMSGRTEFWPEIWRAFTTSPLVGHGYYAGHRSLSIDALANVSSVDNTYLEVLVDLGVIGLGLLMAALICSCFSLYACRPSILGHQDSQWWRPTWLLLMSALLLLGIRSLTGPTFQVLHPNLLIFLAITVCAATAKRIASQMVQVSADTLYPIGEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9S6</accession>
    <name>A0A1W1I9S6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FecR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49798">
        <property type="protein sequence ID" value="SLM49798"/>
        <property type="gene ID" value="NSJP_3631"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3631"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FecR" evidence="1">
        <location>
            <begin position="82"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="374" mass="39334" checksum="579EE4CB83727064" modified="2017-06-07" version="1">MAVAASRWAGSGFLRCPFHVSWRTLAAIIVCTWSLAISGQVFGGESAPAILGVLAGEVTIIPPEGGDAKPVSNGMTVAVGTRVQTGKKSTALVTFLDGSTLTVQPESDVAIKQADIGKTRARVTVGVNVGTVWARIVKLVDPESSFSLQSNTATATVHDGLIGSRQEPDNTFTCWTRAGDLWVLEPTGRVRAILKPGQMETVKAGAPANPQAFFSNHSALRIETPVSVLPVILMPDRARMAGFTDPDTDVNQVFGSYTGLDGEGHRVVEVPAGVPGPFTLILQGEQDGPFLIRIGALYKGVPVDQHQVSGTLQRGARLAAQLTPQLEGMTNDAKTAKVSGVMIGPLESTNMQLPGKVRVSENPSTHPAPAAHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9T7</accession>
    <name>A0A1W1I9T7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3472</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3472"/>
    <dbReference type="EnsemblBacteria" id="SLM49639">
        <property type="protein sequence ID" value="SLM49639"/>
        <property type="gene ID" value="NSJP_3472"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3472"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="441" mass="49302" checksum="4C8D91A50541D3F0" modified="2017-06-07" version="1">MMTLIGQIAGCLIIAAGIGGLVGWFLRQHSVRSLDQQIYDLMTALRVKEQAVTAAQLELKSRTSTMQGYEGKLAATEVLLQTAQEEAAAHSERIKQVQAESSAAIQRVASLESDLASSLQRSVDSEKMVLAFEQEARQANAARTAAQQALSVKDEELSELQNRVAELQGLSAEADQLRSHVAEIEPAQGRLHWLEVQLSEKESHLRTASHDAEEQRAAAAQRGSELDVLKKQLEEQSQLLRDWESRHDKTLRQRATDAKLIETHRETIEELQSTLAERERSAETQAEKIAALQRQFDELSLLYTTLTESQTKGKQDDADRSGTRKRQAEMRAPRKVKGPSESIGRQPLPAENDQLTLEVSSGVQATESRKDDLTRIRGIDPALEQALNKLGTHSFIQIARWTSTDMSRVAKQLATPLDQSKRRNWIADAKKQHREKYGEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9V0</accession>
    <name>A0A1W1I9V0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49794">
        <property type="protein sequence ID" value="SLM49794"/>
        <property type="gene ID" value="NSJP_3627"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3627"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012370783" evidence="1">
        <location>
            <begin position="31"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="172" mass="18334" checksum="7A06DE78F89155ED" modified="2017-06-07" version="1">MSLGMASSRVIRWCACLCACSLLGSACKSADPRNADTNPPAIQWGIADSRVTRSGQTVQVQEGQNIQLTLIAEDHDSGISYTSVGGSGHYTCIAGRITTNIALDKVAEEQNLLPDQRGRLKTKAVQLTDVTLGAQKCPAGAIFSGGTITYTGKSENGQRMQNASTIIFRRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9V7</accession>
    <name>A0A1W1I9V7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Outer membrane lipoprotein Blc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">blc</name>
        <name evidence="5" type="ORF">NSJP_3637</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3637"/>
    <dbReference type="EnsemblBacteria" id="SLM49804">
        <property type="protein sequence ID" value="SLM49804"/>
        <property type="gene ID" value="NSJP_3637"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3637"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002446">
        <property type="entry name" value="Lipocalin_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022272">
        <property type="entry name" value="Lipocalin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01171">
        <property type="entry name" value="BCTLIPOCALIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00213">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocln_cytosolic_FA-bd_dom" evidence="4">
        <location>
            <begin position="34"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="3">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="3">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036893-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="186" mass="20698" checksum="FF1066520D422E14" modified="2017-06-07" version="1">MRTLQSLGIGCIFLAVAACGGIEHREPLTTVATVDLSRYAGTWHEIARLPMWFQRHCVDSKAIYTSRPDGTVGVHNECTTDSGGLDQADGVATVVDHNTNARLAVVFDNFFSRLFGSSRQGNYWILDLDPDYRVAMVGTPDRRYLWILSRTPDLDEPAYEHLVAKAQGLGFPVGDLIRTRRPLHNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAC3</accession>
    <name>A0A1W1IAC3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3775"/>
    <dbReference type="EnsemblBacteria" id="SLM49942">
        <property type="protein sequence ID" value="SLM49942"/>
        <property type="gene ID" value="NSJP_3775"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3775"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015996">
        <property type="entry name" value="UCP028451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="PTHR36452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028451">
        <property type="entry name" value="UCP028451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="227" mass="26027" checksum="AF2627F2D23578B9" modified="2017-06-07" version="1">MASVRFPDDTLAFLHELKDNNTREWFSAHVQDYQQCCVEPAKAFVIAAGRELRELIPGIHAEPSIMGSIFRMNRDARYAKETPYKTHLDFWFWEGERNQAVSGMFARVAPDFLGIGAGCHGFGKERLPMFRRAVADPRQGARLAEVARTAAEKGYVLKGKAYKRYPRDFRTDGLAAEFLLYGALYVHVDEPVRLVTRNGAMLEACVRHWRELAALHEWITEFVQYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAE2</accession>
    <name>A0A1W1IAE2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3850"/>
    <dbReference type="EnsemblBacteria" id="SLM50017">
        <property type="protein sequence ID" value="SLM50017"/>
        <property type="gene ID" value="NSJP_3850"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3850"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="491" mass="54317" checksum="239661828D9A6B4C" modified="2017-06-07" version="1">MSCFVSRPTVQDPARWGVCLSTILTVSILLTASGCGSFGKHYVQADKSLLVHDYQRADAAIKEAEDEYGDKSRVLYGMDRGMTLHLAGDYKQSNLLLEQSDDEVERLYTRKVRTETAAFLTNDNALPYEGDPYEQVMLNVVKALNYAMLGLWQESLVEARRIDHRLNVLSDRVKDKSAYREDGFARYLTGILYESTGDVNNAFIAYRKAYETYDSMKGWSRVGEPRQLQSDLLRTTDGLHLTSEFTAYERAFPGVPWQSVQAQQNLAQVVVISYNGRAPRKEDQFLDLPISMDALQLVLINRALTNPNTPENRAKDSVLYGLNGRVVRVALPKLIPQPTQVPVDIVTLNAASGDPVLVKTEPVHQVTALAEKSLSERLPGIAVKAVARAATKYAMAEAATRGSQSAAGQKNADWVGLLVSLIAHGYAVASEESDKRSWRTLPDQIHLARRWVSPGHYDVRGAGFTGEGPPGSRSLSLSPGQTVFLIQRVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAJ0</accession>
    <name>A0A1W1IAJ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multidrug resistance efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3722"/>
    <dbReference type="EnsemblBacteria" id="SLM49889">
        <property type="protein sequence ID" value="SLM49889"/>
        <property type="gene ID" value="NSJP_3722"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3722"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="2">
        <location>
            <begin position="44"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="329" mass="36152" checksum="6F69691978B87425" modified="2017-06-07" version="1">MTDSRSIARIVLRTVVAITLWTGIQGCTRPDPTLVQGYVEGEFVYVASPYAGALESLAVQRGQQVKEGDGLFRLNGEPEQAAREEAERRLSQAKATLEDAKKGKRPSEIDVIKAQLKQARIAVRLSEREFTRQEALSRVPGATSELELDRTRATRDQDRHRVSELQAELDTAQAGSRSDQIAAAEAEVRAREAALAKAAWELSQKQQQAPKAGLVFETLYREGEWVAAGRPVVVLLPPQNIKVRAFVSQEMVGTLQPGQSVRVSVDGVAEPFVGTVNYISPKAEFTPPVIYSRESRSKLVFMIEARFNPSVAAKLHPGQPVDVRIGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAL3</accession>
    <name>A0A1W1IAL3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3879"/>
    <dbReference type="EnsemblBacteria" id="SLM50046">
        <property type="protein sequence ID" value="SLM50046"/>
        <property type="gene ID" value="NSJP_3879"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3879"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="171" mass="17973" checksum="97DC7FA4596A7BC9" modified="2017-06-07" version="1">MLFLSFRDRSKLVLFRWPAVGAGLSVALGLHIVVSALGLGMAYVGSGSLPEGSTAYWVLAWSGVAWLAAAFIGGYVAAWVSDSSSYVESIFHGLTLWGLLTVILMVLPPTAMSLGAMLAETVPPSDIVSFVAWFVAIGGILSLGTTIWGSIIGSRVVESVETKMTEGYRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAL4</accession>
    <name>A0A1W1IAL4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4 7">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ppdK</name>
        <name evidence="15" type="ORF">NSJP_3865</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4 7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3865"/>
    <dbReference type="EnsemblBacteria" id="SLM50032">
        <property type="protein sequence ID" value="SLM50032"/>
        <property type="gene ID" value="NSJP_3865"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3865"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="13">
        <location>
            <begin position="36"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="13">
        <location>
            <begin position="86"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="13">
        <location>
            <begin position="320"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="12">
        <location>
            <begin position="441"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="14">
        <location>
            <begin position="550"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="915"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="870"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="593"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="649"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="784"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="805"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="806"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="807"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SLM50032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="951" mass="104767" checksum="48BEE2354D70F172" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAR5</accession>
    <name>A0A1W1IAR5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative tonB-dependent receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_3923</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50090">
        <property type="protein sequence ID" value="SLM50090"/>
        <property type="gene ID" value="NSJP_3923"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3923"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030149">
        <property type="entry name" value="FcuA/FatA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF82">
        <property type="entry name" value="PTHR32552:SF82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0798">TonB box</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="STN" evidence="10">
        <location>
            <begin position="83"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM50090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="864" mass="93324" checksum="D11BE342645E242F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB01</accession>
    <name>A0A1W1IB01_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50227">
        <property type="protein sequence ID" value="SLM50227"/>
        <property type="gene ID" value="NSJP_4060"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4060"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="352" mass="38675" checksum="C2BF2921EE88E66C" modified="2017-06-07" version="1">MRILVTGNMGYVGPLVVRRLREAHPGAELIGYDAGYFAQCLTGAKRFPESLVDLQYFGDIRNISDDVVRGVNAVVHLCAISNDPMGALFEGVTLDINHRASVKLAEKAKRAGVKSFVFASSCSVYGFAEGGPRQEEDALNPLTAYAKSKVFTERDLSGLASDGFSVTCLRFATACGMSDRLRLDLVLNDFVAGALVSKRINILSDGTPWRPLIHVKDMARAIDWAVQRDYRDGGTFLTVNVGSDGWNYQVKELAAAVANVVENVEVLINKDAQPDKRSYRVSFAKFSKLAQGYLPSVDLPGAVVDIRNGLAAMKFQDQDFRTGEFVRLVTLRKLREGGQVTEDLLWKERGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB61</accession>
    <name>A0A1W1IB61_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50215">
        <property type="protein sequence ID" value="SLM50215"/>
        <property type="gene ID" value="NSJP_4048"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4048"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="55" mass="6541" checksum="748BE87AD6EC23F0" modified="2017-06-07" version="1">MTIGQAVCREYRIASGFVWPPVPSYRFDNNLLRNPEARVQPHRQQAFDERPRELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBA0</accession>
    <name>A0A1W1IBA0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate 1-decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartate alpha-decarboxylase</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="9 14" type="primary">panD</name>
        <name evidence="14" type="ORF">NSJP_4088</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="9 10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9 12">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PanD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4088"/>
    <dbReference type="EnsemblBacteria" id="SLM50255">
        <property type="protein sequence ID" value="SLM50255"/>
        <property type="gene ID" value="NSJP_4088"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4088"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006246">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00223">
        <property type="entry name" value="panD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5013995343" description="Aspartate 1-decarboxylase beta chain" evidence="9 13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013995341" description="Aspartate 1-decarboxylase alpha chain" evidence="9 13">
        <location>
            <begin position="25"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="9 10">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="9 12">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM50255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="118" mass="13251" checksum="A2DC74A17BDA07CA" modified="2017-06-07" version="1">MFRQMLRSKIHRVTVTGTHLEYEGSLTIDQDLMEAAAILPYEAIICSNMNNGERFMTYAIAGKRGSGDIVLNGPTARKAAVGDQIIIFCYEYYAEEEIKKHAPIIVRVNDKNRIVSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBI2</accession>
    <name>A0A1W1IBI2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein FtsB homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ftsB</name>
        <name evidence="3" type="ORF">NSJP_4082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4082"/>
    <dbReference type="EnsemblBacteria" id="SLM50249">
        <property type="protein sequence ID" value="SLM50249"/>
        <property type="gene ID" value="NSJP_4082"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4082"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023081">
        <property type="entry name" value="Cell_div_FtsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37485">
        <property type="entry name" value="PTHR37485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="116" mass="13415" checksum="25506AEDECF1D999" modified="2017-06-07" version="1">MLIKQNRGKQWLDWQRRLITGAQYAGLGACLLLLLALCFGEMGLPRYFSMKNHAQQLETEILDLQRGVAGLRSDIDRLEHDPLKIEQLAREQLGYVRKGETVYQLYPEATQDRSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBS7</accession>
    <name>A0A1W1IBS7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_4056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4056"/>
    <dbReference type="EnsemblBacteria" id="SLM50223">
        <property type="protein sequence ID" value="SLM50223"/>
        <property type="gene ID" value="NSJP_4056"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4056"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029465">
        <property type="entry name" value="ATPgrasp_TupA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14305">
        <property type="entry name" value="ATPgrasp_TupA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="342" mass="40270" checksum="D6389C0D1C83AAE5" modified="2017-06-07" version="1">MSEDGQLRLLVRAIFPSSWRMALFRKRQLLAECRSEFKQRLSDLFPDRYIQASQFREKFGRDPNFETPATFNEKIHWLMLHYRIPEMTQLADKYGVRQHVAARVGEWPLNDLYGVWEDPDDVNFEELPDSFVLKVTSGSGQNILCKDKALLNIAEARSQLKKWMQENEYWIGREWAYKNIKPRVICEKFLTDDQGHIPSDYKLFCFKGEPRFVQVDTDRFTDHRRDLFDLEWKLLPFQYSYPTSAIQIAKPYHLETMVGLARALSEGFPFVRVDFYSMRERVVFGEMTWYPEGGMGLFNPEKYDLEIGKTLVLPRPVNASLASRIWSKWHGARKLLGSPRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZL1</accession>
    <name>A0A1W1HZL1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46200">
        <property type="protein sequence ID" value="SLM46200"/>
        <property type="gene ID" value="NSJP_0028"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0028"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="255" mass="28152" checksum="3B3B41A658709BA1" modified="2017-06-07" version="1">MGDGYVSLEITMYVLAIVALLGLWLFHQAQVRAGRILAVDLFDRSLVRMYVYAAPQGTTLCTICGQAQGRVFLSTKVDKKGFSPTDGPCEAQGHCQGYLIGLYGGWAEARDVVARLQRSSKKTVVRLSSDELRSLVTGEWGKSVSANTDRLNVHMLEGLCLEAADADRAAAGYRHVIERASDSRHLGFVVPAYLRLIDLLARTGCEEEASKAIEQFERRFPAHLSGSHAPNADQRKILEEEKSLLWTRRSLKVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZS1</accession>
    <name>A0A1W1HZS1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteasome subunit beta 1</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">prcB</name>
        <name evidence="3" type="ORF">NSJP_0045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0045"/>
    <dbReference type="EnsemblBacteria" id="SLM46217">
        <property type="protein sequence ID" value="SLM46217"/>
        <property type="gene ID" value="NSJP_0045"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0045"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022483">
        <property type="entry name" value="PSB_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03690">
        <property type="entry name" value="20S_bact_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="274" mass="29798" checksum="562BA5B60013A121" modified="2017-06-07" version="1">MKLPFLPNHDDSSFFDFLTAQHPDLTPGVRAAALAPAGADVARQAGSVTVPQATTVLGLRYQGGVVIAGDRRATEGFQIAERRIEKVFKIDDYSAMAIAGAAGPCIEMAKLFQTELEHYEKLEGVQLSCEGKANKLGQMVKANLPMVFQGLVVMPLYVGYDLKRGEGRIFKYDLAGGRYEESDYHSIGSGGKDARNAMREHFRKGMSEQDALKLALMALYNAADDDVGTGGPDLVRGIYPTAKIVNATGITDVPEQQIRGIYDEMIAARRAKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZS5</accession>
    <name>A0A1W1HZS5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0086"/>
    <dbReference type="EnsemblBacteria" id="SLM46258">
        <property type="protein sequence ID" value="SLM46258"/>
        <property type="gene ID" value="NSJP_0086"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0086"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="105" mass="11426" checksum="B739C00E8832A3BC" modified="2017-06-07" version="1">MPNPRIEPLKKVLAMDPNDDVAWFGLGKAYMDDGNFEEAVTALRQCITVKPTYSAAYYALAQSLHKLGRHAECREIAATGIDISAKNGDAMVTKNLESLKSSLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZS6</accession>
    <name>A0A1W1HZS6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0084"/>
    <dbReference type="EnsemblBacteria" id="SLM46256">
        <property type="protein sequence ID" value="SLM46256"/>
        <property type="gene ID" value="NSJP_0084"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0084"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="17"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="161"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="292" mass="32738" checksum="756822C4BCA8147C" modified="2017-06-07" version="1">MTHPLLIDTETLQGKLGRPGLVIIDVRGKAAYEFGGHIPGAVNSTWHEYSDPNAVAKGLLDPDPSRMQQRIRALGINDDSEVVIYSNPFDNWGDEGRMFWMLEYFGHKNLRILDGGWVKWIDERRPFEHGRVNVKPGTFVIRINKDAAILKDELRAVVKQSHPQVVIVDARSLEEFLGKEVSGIPRAGHIPSAINIAWNGFLNQNATVKDLQAIQSGLEDKGLHPDQEIVCYCTGGVRSAWLYVVLKLAGFQKVRNYAGSWWEWSRDFACPVEKDFQGLQKVLGVDAPARPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I009</accession>
    <name>A0A1W1I009_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">moeA</name>
        <name evidence="9" type="ORF">NSJP_0164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0164"/>
    <dbReference type="EnsemblBacteria" id="SLM46336">
        <property type="protein sequence ID" value="SLM46336"/>
        <property type="gene ID" value="NSJP_0164"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0164"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="189"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="432" mass="46739" checksum="24C1048F8292A65C" modified="2017-06-07" version="1">MKAKDAMQGLTPLEEAQKIVLDSTPVLGLEKIPLLDTLGRVLGEDIIVERDNPPWDNSAMDGFAVRWDDIKREHPIDKPVTLTVIEDVPAGKMPMKTVGPGQAIRIMTGAPVPKGADTVLKVEDTEHTPDSVRVFKPELKGSNIRPQGEDVKKGERIIAKGTPVRPGEAGMLAILAKSFVFVHQRPRVAILSTGDELADLDERYSEEKIINSNSYGIAAAVQDAGGIPFLLGIAKDNPAALKEKISYGLTADILVLSGGVSMGDYDFTKAVFQDLGAAMNFWKLAIKPGQPLAFGKIQGKLAFGLPGNPVSSMVTFEQLVRPAMLKMGGHRSYGRPVVQALFQEKFSKRADRRHFLRGVLTNEGGVFRVWTTGDQGSGILTSMVKANCLIDVPMEVERLNPGDPISVQLLSEQGWDGHAVHVSGGPHRQSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I023</accession>
    <name>A0A1W1I023_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Cytochrome c-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0162</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0162"/>
    <dbReference type="EnsemblBacteria" id="SLM46334">
        <property type="protein sequence ID" value="SLM46334"/>
        <property type="gene ID" value="NSJP_0162"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0162"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3820.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005126">
        <property type="entry name" value="NapC/NirT_cyt_c_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038266">
        <property type="entry name" value="NapC/NirT_cytc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03264">
        <property type="entry name" value="Cytochrom_NNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrom_NNT" evidence="3">
        <location>
            <begin position="8"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="235" mass="25984" checksum="F316947B87F113A3" modified="2017-06-07" version="1">MSWRPKAITISVLIAGALALGGVAVPLTNHPKFCASCHNITPSYDSWAASSHKEVTCVACHVRPGVEGWLHDKVWAGTRDVFIYTFGTPTDAHNLKASVDSDVCLGCHRNILRVSEVAPRDLPPPVRDVGLVMSHRKHMEAFRLQGRGDGCTSCHSGVVHERPIKGYPIVLPRGHVSADSKPWLPDHPDGSYLRERALKDCFRCHDGKTEHQGKLLDRKCETCHLPDKLKSFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0F4</accession>
    <name>A0A1W1I0F4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46471">
        <property type="protein sequence ID" value="SLM46471"/>
        <property type="gene ID" value="NSJP_0299"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0299"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="167" mass="19385" checksum="AC29613AF18EFD9D" modified="2017-06-07" version="1">MSTVFRHSSRPTFYRRVHIPRKLRQHFKGRVEVWRSLRTADQDEASARSAQFEAQTKRLFVTLKKYGDRMTNEERDILVSHWLESELDYAEDCRVLAGPISDQQRDDYVACPDIMSDEAHEALLGNDYRKIEKEADALLMAGLVDVRKWPMEKLVSQLVVTVIATTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0G7</accession>
    <name>A0A1W1I0G7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0324"/>
    <dbReference type="EnsemblBacteria" id="SLM46496">
        <property type="protein sequence ID" value="SLM46496"/>
        <property type="gene ID" value="NSJP_0324"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0324"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="139" mass="15833" checksum="9EB63B44F71093BB" modified="2017-06-07" version="1">MSRPKLWAGLAVLFAAGALTGVVGMWLYGNTDRMNRSDQGPAAKQERIMKRLTQELSLTTQQQTDIEPVVRRAHLAVLELRFSHQAEVERILTQGMAELKPKLSPEQQAGLDRLYAELQQRWHASRNYVQAQRQAMPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0I5</accession>
    <name>A0A1W1I0I5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46492">
        <property type="protein sequence ID" value="SLM46492"/>
        <property type="gene ID" value="NSJP_0320"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0320"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="182" mass="20085" checksum="178ED7DA09551E3E" modified="2017-06-07" version="1">MVRMQPWKMALVLAAAIMTAGCPRILYLDYQPTTSLKGHGQVQVDPFAYSGHPTGLVRMKEVESSSKDVEALYLSQDIGVFFTNALRGELTFAGYDVQPASPRIVSGKIDQFYLDYVGEQDQLFLIAATFYVAAKDGTSFTSSCRSSQQQPKYWMKTGLLIKSGITECVEQFMKAAQAAKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0P1</accession>
    <name>A0A1W1I0P1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdenum ABC transporter, periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">modA</name>
        <name evidence="5" type="ORF">NSJP_0372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0372"/>
    <dbReference type="EnsemblBacteria" id="SLM46544">
        <property type="protein sequence ID" value="SLM46544"/>
        <property type="gene ID" value="NSJP_0372"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0372"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012054321" evidence="4">
        <location>
            <begin position="25"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="275" mass="29052" checksum="41E405F792C9BAED" modified="2017-06-07" version="1">MMAGMRASGLAAVLTVGLAGICTAGGPNASGMATAVDQPAVASLTVAAAHSLKPLFQEILPIFEIEHGVTVQVLYGPSQTLRQQIEKGAPIDVFLPEGVEEVRKLQKKGLTLNGGAQTYAQTSLVLVMSTTSQAASVSFRDALPDHAIRVALVDPKTSAMGEVTARALTKVDPASRSRSRILHAQHSDDVMNLVSTGGADVGLVYRVDAINSGQVRIIDEAPAGSDLPVQFGHAVVWTCRDSSRDVAEQFFDFIMSPRVQKLLLKYGFDSIPSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Q1</accession>
    <name>A0A1W1I0Q1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two component transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0382</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46554">
        <property type="protein sequence ID" value="SLM46554"/>
        <property type="gene ID" value="NSJP_0382"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0382"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="10"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="149" mass="16351" checksum="0D259AE9B87ED323" modified="2017-06-07" version="1">MVDGRCRPIRLVVAEDNAMMRMVIRRMLADQTDLRVVGEAVDGSEATALTEDLLPDVVVMDINMPRMNGIEAARYIKLHFPHIAILGLSANADEYRDTMLELGAKAVIQKETMYELNGAIRAAVQEIKHSHGTTLTNEPRPGGEPPGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0U6</accession>
    <name>A0A1W1I0U6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0453"/>
    <dbReference type="EnsemblBacteria" id="SLM46625">
        <property type="protein sequence ID" value="SLM46625"/>
        <property type="gene ID" value="NSJP_0453"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0453"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="503" mass="55738" checksum="4A76FA73DF173E1D" modified="2017-06-07" version="1">MTGEGWSRRQFLSAGLGLAGLAFSRPSVFGACSESPQTAACPSISWMDGGRSLIEGYAGRRSYEAGERVSFFMSSQSRIRAMLTVNRLGARREMVWSGPVWVEPQAIPADASESGCRWDGEGGSGLTFDVPAEWKPGFYHVTMHAADGDGEGFFIVRSPRSAPKPGILLILSTNTYFAYNNYGAAQGDALRSTRGSFYDQARVASFLRPLPMGFLSPYDCRKTGIPSRHHRYAGWDKWEWPFVQWAEQAGIDLDYAANEDLERQPERLESYRLILSVGHDEYWSAGMRNAVERHVRQGGNAVFLSGNVSYRKVLLDMSDSRMILDGAMDGAALWSHLQGANRPEHRLTGVSFCYGALNPLPVPYRIYQPDHWLFDGLWSAGGRPERFPDVGCIGYECDGCDIEWDKGIPTASHRDGCPEDFQILALAPGRMPDYEATVHSRALFGRDDGFTPWGADLRQGAAVMGIWTNGGTVLTVGCTEWVRRLDDPLISRITKNALTRLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I110</accession>
    <name>A0A1W1I110_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTTP/UTP pyrophosphatase</fullName>
            <shortName evidence="2">dTTPase/UTPase</shortName>
            <ecNumber evidence="2">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="2">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + UTP = diphosphate + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTTP + H2O = diphosphate + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28534"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Maf family. YhdE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0513"/>
    <dbReference type="EnsemblBacteria" id="SLM46685">
        <property type="protein sequence ID" value="SLM46685"/>
        <property type="gene ID" value="NSJP_0513"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0513"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036221">
        <property type="term" value="F:UTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="211" mass="23087" checksum="B8212638DDF8D8BD" modified="2017-06-07" version="1">MRVVLASTSPRRRTLLSLLGLTFDVRSPVCDEQIIAGRTAPELASFFAKRKAHSIAAIDPEAVVIGSDTLIELEGAVLGKPYDLEDARRTLRALAGRRHEVHTAVTVVSLTRGFDKTKLETTQVRMRAYEADAHERYLATGDSLGKAGSYSIQGPGVELIESFDGDFTTVVGLPLRVVHGLLSQAGVPMPADIVQIYRQKPYENWARMSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I145</accession>
    <name>A0A1W1I145_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_0532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46704">
        <property type="protein sequence ID" value="SLM46704"/>
        <property type="gene ID" value="NSJP_0532"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0532"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010712509" description="Thioredoxin domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="18"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="215" mass="23592" checksum="9935348E8EE23EEA" modified="2017-06-07" version="1">MIFASIRNSMITLLAGLALVSTGAVQAGTIADDGRIRGRADAPITLVEYSDFTCGYCLKFFRDTLPRLQAKYIDTGKVKFVYRDYPRTDRGVGVDAAVAARCAGAQGRYWAMHDRLFTEGGRLETGAFKGFAKAIGLDQAAFGQCFDERRHLESIFQDRQEANRWGFHGTPGFILMYTAAGPTEKDPAVAIPGAFPFEAFAEEIDRMLSKKAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1E2</accession>
    <name>A0A1W1I1E2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46807">
        <property type="protein sequence ID" value="SLM46807"/>
        <property type="gene ID" value="NSJP_0635"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0635"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012009132" evidence="1">
        <location>
            <begin position="20"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="76" mass="8517" checksum="60C18081D28518F5" modified="2017-06-07" version="1">MQSCKLLRLALMAMLALLAGCMTDSVMLVHPQTQQAAQCGPYYYTGTSSGLFSKAAAMERERDCISDYQRQGYERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1J5</accession>
    <name>A0A1W1I1J5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0690"/>
    <dbReference type="EnsemblBacteria" id="SLM46862">
        <property type="protein sequence ID" value="SLM46862"/>
        <property type="gene ID" value="NSJP_0690"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0690"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="236" mass="24820" checksum="553E5705FB5BE4A4" modified="2017-06-07" version="1">MRYVQRLVNISVIGTGIVLFGLPVGYAPAQPAAPPAGAVSAVPDPSRSTVSGTIAQYLMNHHGDIDGLLLEDGLQVHVPPHMAKELAATVKPHDAVTIQGYRSPDGPVIASPVITNTKTGRSLTEHEPGPFDRPILPPHVKDMFLAEKHTHGIVQTLLYGPRGEINGVVLDNHAIVHIPPHATQQTASLLQPGHSIDAVGYGTENHYGLAIEATAVGATGSPLTPIPQPGSAELRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1L3</accession>
    <name>A0A1W1I1L3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">tatA</name>
        <name evidence="9" type="ORF">NSJP_0710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a complex with TatC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0710"/>
    <dbReference type="EnsemblBacteria" id="SLM46882">
        <property type="protein sequence ID" value="SLM46882"/>
        <property type="gene ID" value="NSJP_0710"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0710"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="99" mass="10802" checksum="BF76D9883363A41A" modified="2017-06-07" version="1">MFGLGAGEILIILVIAFLLFGPKQLPEVGRQVGKAVKGFKETAEDLRKSVEPELNMIQQEVKMVEQDFQASMKEAEEEINAATTPVEKPSGSTETGNHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1L6</accession>
    <name>A0A1W1I1L6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EVE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0699"/>
    <dbReference type="EnsemblBacteria" id="SLM46871">
        <property type="protein sequence ID" value="SLM46871"/>
        <property type="gene ID" value="NSJP_0699"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0699"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="1">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="165" mass="18908" checksum="FB2D3C9B88F2DFC8" modified="2017-06-07" version="1">MSASRRYWLVKSEPSVFSIRDLAKSPKQRTSWDGVRNYQARNYMRQMVLGDQVLFYHSNADPPCIVGIAEVVRTAYADDTQFDKSSHHYDPGSSKSAPRWDMVDLGYRREFPVSLSLDRLRGEPDLKRMELLRKGSRLSVQPVTPSEWNCILELAGVGKKNRKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1W0</accession>
    <name>A0A1W1I1W0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0677</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0677"/>
    <dbReference type="EnsemblBacteria" id="SLM46849">
        <property type="protein sequence ID" value="SLM46849"/>
        <property type="gene ID" value="NSJP_0677"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0677"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012529059" description="PDZ domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="44"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="150" mass="15345" checksum="10BF88F333EC473A" modified="2017-06-07" version="1">MRINPISGATGVTMSLLLTAAVWAADQPMSQAPYAHGDEAKLPGGVIGVSLQVGAERIGDPAVLYVGMVHPEGPAQQAGLRHGDEIVSVDGTAVSGKTYEQVVRMIRGDAGTIVKLGVKGEDGAREITISRVAGDKLPKGPSGSHGDPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1X0</accession>
    <name>A0A1W1I1X0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0687</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46859">
        <property type="protein sequence ID" value="SLM46859"/>
        <property type="gene ID" value="NSJP_0687"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0687"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="249"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="458" mass="49836" checksum="A8E1230660E577B1" modified="2017-06-07" version="1">MSSAWGTRIQAALAMALFLGSLGTLLYNSYAATTLPQHELQARTSLQAVSRLLADAAESVLPKSPARSPQQLDDLHAALLPVTNRVLATFSGVEGGFYLRDADRFAGYGFPTADGHHPVDVRRTDPPPLETPLIRVQALQSLSEQTPLFSVRDVGPSRVMVVTQAVGTARPAPAVTWAMLRLTGPEQLGGQLRRYQVSVGLALAGFLCSLALAFTLTRSLAGQRTAQEQLREELRRSEQLASLGKLLAGLAHEIRNPLAGIRSTVQLWQRMRDPAKMTGSLEAVVEATARLDEILTRLLHFARTEHAERRPLQVNDLVVETFRLLDAHAQDQHVVLESDLAPTLPPVTGSPSSLRQVLLNLATNALQAMPSGGTLRCRTRHDKPAGMVEVTIADTGSGVSQSDRQHLFEPFFTTRPEGTGLGLALCREILTQHGGLIELMTRQEPGATFRILLPVRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Z3</accession>
    <name>A0A1W1I1Z3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46843">
        <property type="protein sequence ID" value="SLM46843"/>
        <property type="gene ID" value="NSJP_0671"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0671"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="91" mass="10024" checksum="E9ECF77C877AA373" modified="2017-06-07" version="1">MGIESDTDSGRTSSRALHYSSPCARCGGLMVNHFLTDLLNHAGELEIEMLRCVQCGEVVDSVILRNRLRQVAMMVKNSEPSGRSIARRMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I222</accession>
    <name>A0A1W1I222_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47044">
        <property type="protein sequence ID" value="SLM47044"/>
        <property type="gene ID" value="NSJP_0872"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0872"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="144" mass="16469" checksum="955D788227DF3503" modified="2017-06-07" version="1">MAVRLPRIRLKSVDLPTFGRPMMATSGIGDIRELSVGCDDMEIRRMQATRTLTQEFSQRQQPPLSDATVAGRFPARPRLYSGRWTRFHRPRRHRGLIGPRSTTSWSTWTEPCWIVTSTISFSRKNYPAGTRCASDCPSENRGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I249</accession>
    <name>A0A1W1I249_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">nusA</name>
        <name evidence="10" type="ORF">NSJP_0767</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0767"/>
    <dbReference type="EnsemblBacteria" id="SLM46939">
        <property type="protein sequence ID" value="SLM46939"/>
        <property type="gene ID" value="NSJP_0767"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0767"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="135"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM46939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="383" mass="42625" checksum="4ED682604F228988" modified="2017-06-07" version="1">MNRELISVIDEIGRQKGIDKTKVIGAIEAALQTAAKKRFGQAENIQVEIDAKTGEISVVSKKIIVDAVTNPKAEISLKEARQYDSEAEVGDEIGSLIEMDELGRIAAQTAKQVIFQKVREAEWEAVQKEYSTRQGDLVNGIILGMERRNYLVDLGKTEAVLPIQEQIPRETYRRGDRVKAMLLEVRRTPKDVQVILTRSHPQFVSKLFELEVPEVMEKIVEIKAVVREPGDRTKIAVTSREKAVDPVGACVGIKGSRVQAVVRELRGEKIDIITWTTDPRVFIAEALNPATIEKVGVDEEKKSALVVVADSQLSLAIGKNGQNVRLAARLTGWKIDIISATEYEKEKAERDREIKAALAEEAEAQRQQEEARQQEKAQAEAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2A3</accession>
    <name>A0A1W1I2A3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease III</fullName>
            <ecNumber evidence="3">3.1.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xthA</name>
        <name evidence="3" type="ORF">NSJP_0952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0952"/>
    <dbReference type="EnsemblBacteria" id="SLM47124">
        <property type="protein sequence ID" value="SLM47124"/>
        <property type="gene ID" value="NSJP_0952"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0952"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09086">
        <property type="entry name" value="ExoIII-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037493">
        <property type="entry name" value="ExoIII-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250">
        <property type="entry name" value="PTHR43250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="258" mass="29782" checksum="E2A3BCF6557FB1FD" modified="2017-06-07" version="1">MKIATFNVNSLRKRLQIVLDWLEHNKPDVLCLQETKVQDSEFPLLGLAPCGYEITFRGMKSYNGVAILSRKKPDVVRAGLDDGGEPDEPRLLHVVIDGIPIINTYIPQGFEIDSPKYAYKLEWYKRLRCYFDKHLSPDAPAIWCGDMNVAPRPMDVHSPEKHLKHVCYHEDAKNAYQGTLGWGFHDVFVRLYPNRQQYTFWDYRAPSSLESNKGWRIDHILATAPLAERCIKADVDVEPRRAKDPSDHTFLWAEFSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2E5</accession>
    <name>A0A1W1I2E5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1018"/>
    <dbReference type="EnsemblBacteria" id="SLM47190">
        <property type="protein sequence ID" value="SLM47190"/>
        <property type="gene ID" value="NSJP_1018"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1018"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="148" mass="16335" checksum="FCC7D13E3200229C" modified="2017-06-07" version="1">MKAHYLGHVVFYVKDLQRSLTFYRDLLGFKEVGQIFDGAAAALTSGRTHHELLLIQVGDAPGPPSGRRRGLYHIGIKVGDNLAELRAAKQELERAGIAIEGMSDHTVSQSLYLRDPDGNEVELYVDADESLWKNDPAAVVSPIKPLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2E9</accession>
    <name>A0A1W1I2E9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA gyrase subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">gyrA</name>
        <name evidence="10" type="ORF">NSJP_1006</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1006"/>
    <dbReference type="EnsemblBacteria" id="SLM47178">
        <property type="protein sequence ID" value="SLM47178"/>
        <property type="gene ID" value="NSJP_1006"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1006"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="9">
        <location>
            <begin position="10"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="8">
        <location>
            <begin position="526"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="825" mass="92033" checksum="91D3BBDA8C230A5D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I341</accession>
    <name>A0A1W1I341_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47385">
        <property type="protein sequence ID" value="SLM47385"/>
        <property type="gene ID" value="NSJP_1213"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1213"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="61" mass="6713" checksum="303C9AB975F3881B" modified="2017-06-07" version="1">MTARCRKADGPRWLGIQNPISLDGGTGVDCRDAVPKTGRRELGISRVRLWLDRGAPSRHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I348</accession>
    <name>A0A1W1I348_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47414">
        <property type="protein sequence ID" value="SLM47414"/>
        <property type="gene ID" value="NSJP_1242"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1242"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="394" mass="45277" checksum="5B40D96FB04D8698" modified="2017-06-07" version="1">MSLENSNDPFFALTEEGTKWNACIGKQAHPESYMDGYMEAALELVNAVIEQKQYIKRDTLAMPILYNARHALELSLKYIYDAFLKEKLIKTTLNKNHDIRSYWALLLSTKVGDLELTQHIKSLERFVVSLGNIDDDGQELRYATTRDGQKSLKDKALCNLVVIRKSLLELQKIIYDSKYRLEGFVDERQTKTYTKDLSRNDLGTISKMLPPIDRWTDDAFVKTKEEIKEAYGIGSNKFSDAINLIKNHRTMAARLGKEFDLLYLTDHKLKLVVQEWKGLHPPPDLNDLGTDFTNADFEAMIGHAKKVEEVQKNILRFLSGDEIADLETVFYIGREAGFCEFYERQLTLVRNKHKLNTNPAQEVRHLIEKVNFLEEIAKGLTILGKPTLAKNLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I356</accession>
    <name>A0A1W1I356_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47405">
        <property type="protein sequence ID" value="SLM47405"/>
        <property type="gene ID" value="NSJP_1233"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1233"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="75" mass="8381" checksum="02718A73B90E8E4C" modified="2017-06-07" version="1">MGLRRRFVIFALPEQHGGRNFYISKSGGITDIPPAVAKFSSFAEAQAFAASHNIELTAARYIGQADFMEWDCREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I384</accession>
    <name>A0A1W1I384_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47339">
        <property type="protein sequence ID" value="SLM47339"/>
        <property type="gene ID" value="NSJP_1167"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1167"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="200" mass="21916" checksum="41109E7132DAD9D0" modified="2017-06-07" version="1">MTLFSTLMARSGRSRRRADGFGSSESVPWDADSFPYHTVRRSIDLASMVPDGDRERVQPATVGKRTRARLSLSRRAIVFLCAAGGLGLVLLSLAHAARTQSSLSPERGRRNSTVRPARIGAAHPARFDDHPDRRIAATRRRSAPGAPPGSRITNPRYGDVASTDRPNRWDRFACSNPNDSSEDSHAAHIDSRSIKSQGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3B2</accession>
    <name>A0A1W1I3B2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47451">
        <property type="protein sequence ID" value="SLM47451"/>
        <property type="gene ID" value="NSJP_1279"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1279"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="77"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="274" mass="31421" checksum="F03F106954A99A0D" modified="2017-06-07" version="1">MPTTYTERFARNTELIHAYAGDNSPRMAEIKHLYAILKRLNAKHVLNVPFEGNLVKTIARTEAITFADFIVPDTLDEWNIIQTDYELTGIPRDHFDAVLSIAGIHHLTDQEQLQFIVATRQVLRRGGRLLMVEVTSESSTSRFLDTFVGRYTPTGHTGNYLKDDFVGVLSQAGYRRITRKTIVHEWIFAHEEHLYIWMTKFFGIRVSKPVLLRHVRDLLGMRRSGNGLKIDWRLDFVSAETEKMPRKISSLRSPGKTSPSRLPADASTRRRVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3E1</accession>
    <name>A0A1W1I3E1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="7">S12 MTTase</shortName>
            <shortName evidence="7">S12 methylthiotransferase</shortName>
            <ecNumber evidence="7">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">rimO</name>
        <name evidence="12" type="ORF">NSJP_1355</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1355"/>
    <dbReference type="EnsemblBacteria" id="SLM47527">
        <property type="protein sequence ID" value="SLM47527"/>
        <property type="gene ID" value="NSJP_1355"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1355"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103039">
        <property type="term" value="F:protein methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00274">
        <property type="entry name" value="ribosomal_protein_S12_methylth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01125">
        <property type="entry name" value="TIGR01125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="10">
        <location>
            <begin position="24"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="166"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="9">
        <location>
            <begin position="399"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM47527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="468" mass="52411" checksum="B925AAD4743222D2" modified="2017-06-07" version="1">MTVRLIKPDSPSRKRSSPVSDRKTTIGFVNLGCSKNQVDSEIMLGTLVQDGFELTADPKKAEVVIVNTCGFIEEAKQESIDTILEQSKLKTSGRCRVLIAAGCLAQRYQGDLLKELPELDGVVGTGEFGRIAEICRDLLAPRKRHRRLWLSKPPYLYDELAPRLRLGTAHSAYVKIAEGCNRNCAFCAIPLMRGKQRSRPVESIVAEAHRLASEGVKEINLISQDTVNYGVDLGIRHGLAALLRELVKVKDLVWIRPFYLYPQQVTDELLDLYAGEERIANYIDMPLQHITDRMLNRMHRLGDRAAIERLVERIRRRIPGVTFRTAFIVGFPGETEADFEALKHYVERAEFDRVAAFLYSDEEDTPAVSLDDKIERAIMEERRNELLAIQESIAAAKGREQIGTVMEVLVDGPSEETEHLLQGRHQGLAPEIDGVVYINDGIAAPGDRVKVEISDSGVYDLVGHVVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3F9</accession>
    <name>A0A1W1I3F9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RES domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1247"/>
    <dbReference type="EnsemblBacteria" id="SLM47419">
        <property type="protein sequence ID" value="SLM47419"/>
        <property type="gene ID" value="NSJP_1247"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1247"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014914">
        <property type="entry name" value="RES_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08808">
        <property type="entry name" value="RES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00953">
        <property type="entry name" value="RES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RES" evidence="1">
        <location>
            <begin position="172"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="345" mass="38883" checksum="BA545636C715676A" modified="2017-06-07" version="1">MKCCPECFGDRGLRHNIFPLLATEKGACSFCTMENQALLNPKQLQDYFELLVSAYRPDANGKLLVHWFRNDWGLFMNPIMNDAKAKELLGEVLDDGDIVRKPFLPSEIVDKDRLSEWEKLREELMYRNRFFPDVELDEERLKNLLSHLSVTAGEVPDVWYRARIKTEDVPFPIEKMGAPDKRIAGHGRANPAGIPYLYLGSNPKTAVSEIRPHTGEKACVADFRTPAPPELKLVDLRQPRRTVSPFLLAEALDIQKMRNDLPFLERLGLELTTPVLPQAAAVDYTPSQFLCEFIKQCGYDGVIYRSSVSDGMNLALFYPEKAQPGSVVDYTVTSVTVAVAETGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3G3</accession>
    <name>A0A1W1I3G3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RF_PROK_I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yaeJ</name>
        <name evidence="4" type="ORF">NSJP_1364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1364"/>
    <dbReference type="EnsemblBacteria" id="SLM47536">
        <property type="protein sequence ID" value="SLM47536"/>
        <property type="gene ID" value="NSJP_1364"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1364"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="3">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="136" mass="15588" checksum="A1EE9C37E69E7F25" modified="2017-06-07" version="1">MLQISSHVIIPDSEIEIHAVRSQGAGGQHVNKVSSAIHLRFDIAASSLPPFYKEALLKLHDHRISSDGMITIKAQEHRSQEQNREGALTRLRVLIQSVAIPRKKRRATKPTRTSKERRMDSKTKRGRLKELRRRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3K1</accession>
    <name>A0A1W1I3K1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycine cleavage system P-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">gcvP</name>
        <name evidence="9" type="ORF">NSJP_1359</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1359"/>
    <dbReference type="EnsemblBacteria" id="SLM47531">
        <property type="protein sequence ID" value="SLM47531"/>
        <property type="gene ID" value="NSJP_1359"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1359"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="960" mass="105744" checksum="CFF1A3E4F542C56D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3L6</accession>
    <name>A0A1W1I3L6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation initiation inhibitor protein Soj</fullName>
            <ecNumber evidence="2">3.6.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">soj</name>
        <name evidence="2" type="ORF">NSJP_1412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1412"/>
    <dbReference type="EnsemblBacteria" id="SLM47584">
        <property type="protein sequence ID" value="SLM47584"/>
        <property type="gene ID" value="NSJP_1412"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1412"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="258" mass="28390" checksum="EBDF829C8A61856B" modified="2017-06-07" version="1">MAKTIAVANQKGGVGKTTTSVNLAAGIALQGKQVLLVDMDPQGNATSGLGLDPRSLQNNIYNCLINKDNIDEVLKKTEIGDLYVLPSNPDLAGAEIELVNMDERERRLWHVLRTIEDRFDYVFLDCPPALGILTVNALCAARSVLIPVQCEYYAMEGLTRLIDSIERVRHSLNPELTIEGIVLTMYDVRNTLARQVSDQVRAHFTDKVYQTTIPRNVTLAEAPSYGRPVLLYNMASTGAQSYLSLAKEFLGHGEKSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Q5</accession>
    <name>A0A1W1I3Q5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="6">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">mnmE</name>
        <name evidence="6" type="synonym">trmE</name>
        <name evidence="9" type="ORF">NSJP_1409</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1409"/>
    <dbReference type="EnsemblBacteria" id="SLM47581">
        <property type="protein sequence ID" value="SLM47581"/>
        <property type="gene ID" value="NSJP_1409"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1409"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TrmE-type G" evidence="8">
        <location>
            <begin position="237"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="247"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="266"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="291"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="472" mass="50442" checksum="8AF3DF4164ED9E46" modified="2017-06-07" version="1">MRGSLDDTICAVATPVGEGGVGIVRLSGPDVLRIAGVVVRLRSGRLLGAAATHSLLLADVVPPASMTIHEMDSQASPMRFLDEALVVYMKGPRSFTGEDVVEIQSHGGGLILSLICQACVEAGARLAEPGEFTKRAFLNGRVDLSQAEAVLDTVRARSAASLHVAQRQLRGALAREVESIRTALLGLLAHVEAGIDFVEEDISFVTGEELRRTIQDAILMIRRLSRSFRMGKVLREGARVVILGRPNVGKSSLLNQLLREDRAIVTATPGTTRDVIEESIDLEGVRIHLVDTAGLRETEDPVELEGIRRTKLAQQEADLALVVLDGSQALTDEDRQVMDAVRERPRIIVVNKGDLSPVVRVEELASHSLICPVSAATGAGLDRLRTELRGQLMSGGGDAAEAVIVTNVRHQAALQRAAQAANQALESLGQGAAVELIADDLRATAEALGEITGTITTDEILERVFAEFCIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Z0</accession>
    <name>A0A1W1I3Z0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47728">
        <property type="protein sequence ID" value="SLM47728"/>
        <property type="gene ID" value="NSJP_1556"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1556"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="71" mass="7306" checksum="8338575ED7904A57" modified="2017-06-07" version="1">MTDEGDLKRISGIGVDGEGVRKIASHFFLSSVTPLGSTSLSDSSLTAALAYVEGLTPAAQVAARDVRNARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Z4</accession>
    <name>A0A1W1I3Z4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="4">BPG-dependent PGAM</shortName>
            <shortName evidence="4">PGAM</shortName>
            <shortName evidence="4">Phosphoglyceromutase</shortName>
            <shortName evidence="4">dPGM</shortName>
            <ecNumber evidence="4 5">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">gpmA</name>
        <name evidence="6" type="ORF">NSJP_1523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="4 5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1523"/>
    <dbReference type="EnsemblBacteria" id="SLM47695">
        <property type="protein sequence ID" value="SLM47695"/>
        <property type="gene ID" value="NSJP_1523"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1523"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="156"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="201" mass="22828" checksum="33ED7B0596EE5A26" modified="2017-06-07" version="1">MARVVLLRHGESQWNLENRFTGWVDVPLSERGIQEARNAGEKLRGFTFDRAFTSVLMRANETLRLALETIGQTALPIQKDKALNERMYGDLQGLNKAETAKKYGDEQVKIWRRSYDVRPPGGESLKDTAERVLPYYEKTIKPHLLKGETILIAAHGNSLRALVMELEQLSREQVLELNIPTGAPLLYELDGGGKVRSHRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I416</accession>
    <name>A0A1W1I416_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47715">
        <property type="protein sequence ID" value="SLM47715"/>
        <property type="gene ID" value="NSJP_1543"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1543"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="59"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="168" mass="18934" checksum="15DB38A4E4E691B5" modified="2017-06-07" version="1">MKSLRCPNCGTPFVRVTPHEGTVERLLSRFNMFPFRCQLCTNRFRAFYPGARQNTQTFDRREFKRLFASIEAQVLDERQSPFLNRITDISMAGCTLVGTGFAKGAFVELVLKPTSGSEEIRIETAMVCSIHPASVGLRFLEVEQADKERLSQVVLGLLVSQTNPIMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I420</accession>
    <name>A0A1W1I420_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Excinuclease ABC, subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">uvrA</name>
        <name evidence="8" type="ORF">NSJP_1595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1595"/>
    <dbReference type="EnsemblBacteria" id="SLM47767">
        <property type="protein sequence ID" value="SLM47767"/>
        <property type="gene ID" value="NSJP_1595"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1595"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="170"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="495"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="535"/>
            <end position="542"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="835" mass="91350" checksum="ED7F32D6F84787AB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I449</accession>
    <name>A0A1W1I449_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lactoylglutathione lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1616"/>
    <dbReference type="EnsemblBacteria" id="SLM47788">
        <property type="protein sequence ID" value="SLM47788"/>
        <property type="gene ID" value="NSJP_1616"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1616"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="132" mass="14641" checksum="79808E80D7B23B74" modified="2017-06-07" version="1">MRVAKFLHTRMRVTDLDRTIRFYTEVLGLDVLERKTSPRGSQLAFLKVPNSDELIELTSFPPSGPVRVQEDLVHLAFQVENLDDTIVALGAKGVPITDGPTTTSSGSRFIFIDAPDGYEIELIERPNGVTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I455</accession>
    <name>A0A1W1I455_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2726 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47603">
        <property type="protein sequence ID" value="SLM47603"/>
        <property type="gene ID" value="NSJP_1431"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1431"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024402">
        <property type="entry name" value="DUF2726"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10881">
        <property type="entry name" value="DUF2726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2726" evidence="1">
        <location>
            <begin position="45"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="169" mass="19510" checksum="D44B7427695F9850" modified="2017-06-07" version="1">MDQVLFWSALVIGICAMWWFKASRKQTPTQTEERTLPTGVILEPQPLLSDRDVRLYNLLRMAAQDRYIILARVPLLGILRVQVEGSGRMQMLRRMALQHVDFVLIHPGCRLVEHVVQVEGDQELNARETEKRQDIRRIVHASGIHLVVLEADRFYSVRQLEEMLGLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I469</accession>
    <name>A0A1W1I469_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47808">
        <property type="protein sequence ID" value="SLM47808"/>
        <property type="gene ID" value="NSJP_1636"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1636"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="60" mass="6992" checksum="9683A8B50EA2DFB5" modified="2017-06-07" version="1">MVRMFIEKAHIALPVTAISGCRAWGNLASFLCDRYSLMGEKGDRHDERLYRTARRRHAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I494</accession>
    <name>A0A1W1I494_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1650"/>
    <dbReference type="EnsemblBacteria" id="SLM47822">
        <property type="protein sequence ID" value="SLM47822"/>
        <property type="gene ID" value="NSJP_1650"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1650"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="77" mass="8516" checksum="84EE76D9CEC74E4D" modified="2017-06-07" version="1">MGKTLLRVGEAAEFLSVSRWTIYRWVEQGRLEGTRIGKGSVRVFQSSLDRLIQQNKTGEIGPSGMASAAAYCQPRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4A2</accession>
    <name>A0A1W1I4A2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit B</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">nuoB</name>
        <name evidence="4" type="ORF">NSJP_1633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1633"/>
    <dbReference type="EnsemblBacteria" id="SLM47805">
        <property type="protein sequence ID" value="SLM47805"/>
        <property type="gene ID" value="NSJP_1633"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1633"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1 2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="3">
        <location>
            <begin position="39"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="159" mass="17728" checksum="4D4AC478BEB8E1FC" modified="2017-06-07" version="1">MSFLERQLEANIITTNLDAVVNWARKSALWPMTFGLACCAIEMIASVSSRYDIDRFGAGVFRASPRQSDLMIVAGTVTRKMAPVIRRIYDQMPEPRYVISMGSCATSGNHYNSYAVVQGVDQIVPVDVYVPGCPPRPEALLDGLLKLQEKIQREKVFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4D7</accession>
    <name>A0A1W1I4D7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Metallophosphoesterase</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1567"/>
    <dbReference type="EnsemblBacteria" id="SLM47739">
        <property type="protein sequence ID" value="SLM47739"/>
        <property type="gene ID" value="NSJP_1567"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1567"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="57"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="285" mass="31955" checksum="582D705718880F2A" modified="2017-06-07" version="1">MTVRQISWPDRIRSWVGSCLSEPLYRLFSLVPDLEVGLGQHEVTTITQVHGPLAGRRAVHLTDLHLDRYQPRHDRIVEAVQELSPDWIFITGDLLNVPEGLPHLFRFLANLRSVAPVFVTLGNHDHYSGVPPSDFSRLADRHGITLLVNQTAYIPTGVGELAIAGVDDPSLHRADLSCVPPPAHRRFTLLLAHAPNILDQLREHHAVDLVLCGHSHGGQWRFPGIPTFWLPPGCNGRIAGKHETSRHRLYINRGIGWSFMPFRYRCKPEIGVIDWVNEQAGARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4H7</accession>
    <name>A0A1W1I4H7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_1742</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1742"/>
    <dbReference type="EnsemblBacteria" id="SLM47914">
        <property type="protein sequence ID" value="SLM47914"/>
        <property type="gene ID" value="NSJP_1742"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1742"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="41"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="236" mass="26152" checksum="3EDFF1F484634B1E" modified="2017-06-07" version="1">MDVRTADSIADRLRIVMDRIRQTALAVGRDPNGIRLVGATKKVSAERVREAVAAGLRVAGENRLQEAIPKIQALRDEPLRWHFIGHLQRRKVRDVVARFEVIHSVDTLELASEIDRRAQAAAIRQDVLLEVNVAGESTKAGFSPHQLEEQFAQFSGLTHLRIRGLMTIPPPVDDPEQARIHFRTLRELAGRLSALAVPEVAMTELSMGMSSDYEVAVEEGATLVRVGTAIFGRRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4I1</accession>
    <name>A0A1W1I4I1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">ftsA</name>
        <name evidence="8" type="ORF">NSJP_1738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Self-interacts. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="5">Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1738"/>
    <dbReference type="EnsemblBacteria" id="SLM47910">
        <property type="protein sequence ID" value="SLM47910"/>
        <property type="gene ID" value="NSJP_1738"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1738"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02033">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020823">
        <property type="entry name" value="Cell_div_FtsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02491">
        <property type="entry name" value="SHS2_FTSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003101">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01174">
        <property type="entry name" value="ftsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="7">
        <location>
            <begin position="8"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR003101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="411" mass="44023" checksum="877294170662BE90" modified="2017-06-07" version="1">MAKRDQILVGLDIGTTKICAIVSEITDDGALSIIGVGSSPSRGLRKGVVVDIESTVESIKKAVEEAELMAAVQINSVYTGIAGSHISAENCKGVVALKKAEVTRDDVQRAIESARTLAVIPHERRILHVLPREFMVDGQEGVREPLGLSGNRLEVNVHVITGAVTSAQNIIKSVNRAGLDVVDIILQPLASSEAVLSQEERDLGVAMVDLGGGTTDLAIFLDGSIRHSAVLPIGGQNLTKDLAIGLLTSQTEAEKIKVQYGLARTDLVHGHERVEVPSVGDRPARTFSRRDIAEILEPRVDEMFELVRREIARAGYEGMLGAGVVITGGTSLLDGMPDAAEHVLNLPARRGVPGGVGGLRDIVSNPMHATGVGLLMHARRHTEELAAAGMRNGRPLSRVFDRMKSWMFEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4K9</accession>
    <name>A0A1W1I4K9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5981 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47957">
        <property type="protein sequence ID" value="SLM47957"/>
        <property type="gene ID" value="NSJP_1785"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1785"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022026">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12225">
        <property type="entry name" value="DUF5981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5981" evidence="2">
        <location>
            <begin position="33"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="82" mass="9163" checksum="218ED790F6CB74E8" modified="2017-06-07" version="1">MNQRVMIPGEDEGAQHVGGVHKRPPIPDNSLKAECPKFMSHGPCGGVRKGGLCEVYPEMKCPWVSLFIELEKIGQTEWMKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4L1</accession>
    <name>A0A1W1I4L1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47948">
        <property type="protein sequence ID" value="SLM47948"/>
        <property type="gene ID" value="NSJP_1776"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1776"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="89" mass="10024" checksum="125B14889C174A9C" modified="2017-06-07" version="1">MRRTSRSSTKPVASCSPINPSRPPPRNPTSTALVANTTIINHTHGVADDPAAPVKRTTEMGPSHDGNRFMRESWYSTRRRRRWGSQLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4L9</accession>
    <name>A0A1W1I4L9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sterol desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1782"/>
    <dbReference type="EnsemblBacteria" id="SLM47954">
        <property type="protein sequence ID" value="SLM47954"/>
        <property type="gene ID" value="NSJP_1782"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1782"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="2">
        <location>
            <begin position="97"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="258" mass="30868" checksum="2CBBA8D3C1F6616B" modified="2017-06-07" version="1">MEWFEWVFTREFRQYLLAHDLVFPLLFLIRLLGVTAIELIRPARKVEYSRVIVYDFAVFLLYQFIIFPIAGYIDLWIAVRPNLPDVVLNLPLPLRVTAYFVIADFGHYWIHWLMHTAPVWRIHKWHHVPTYMYWLAGVRATIPQQVIVNLPYIFAYSFLDLSPWWMYLAIGMFNALQNDWMHMNVAWRFKWLEWLIVTPRYHHIHHSNRPEHYTANLAALFTVWDRLFGTYVDPDKVSEPLSFGIGEKVPLPRLALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Q1</accession>
    <name>A0A1W1I4Q1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bis(5'-nucleosyl)-tetraphosphatase (symmetrical)</fullName>
            <ecNumber evidence="4">3.6.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ap4A hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diadenosine tetraphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">apaH</name>
        <name evidence="10" type="ORF">NSJP_1783</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24252"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.41"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Ap4A hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.41" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1783"/>
    <dbReference type="EnsemblBacteria" id="SLM47955">
        <property type="protein sequence ID" value="SLM47955"/>
        <property type="gene ID" value="NSJP_1783"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1783"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008803">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07422">
        <property type="entry name" value="MPP_ApaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004617">
        <property type="entry name" value="ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000903">
        <property type="entry name" value="B5n-ttraPtase_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00668">
        <property type="entry name" value="apaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="9">
        <location>
            <begin position="4"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="269" mass="29883" checksum="FA42571D2081E6A2" modified="2017-06-07" version="1">MATYAIGDVQGCRDQLSRLIDRIHFDPTRDRLWFVGDLVNRGPDSLGVLRLIKNLGTAALAVLGNHDLFLLAAAEGIVTLRPKDTIDDVLGADDRPELMDWLRKLPLLVHDQSALMVHAGLLPQWTAADAMQLAHEVDEALAGPEYREFLRDFFHASLPPWHPSLTGRMRRASVARVMTRIRSCTPAGEMSGFSGAPKDVPPGYVPWFRIPGRRSADTTIVTGHWAALGLQLKPNHLAIDSGCVWGRYLTAVRFEDRAVFQVEGPRPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Z9</accession>
    <name>A0A1W1I4Z9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmid replication initiation factor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1912"/>
    <dbReference type="EnsemblBacteria" id="SLM48084">
        <property type="protein sequence ID" value="SLM48084"/>
        <property type="gene ID" value="NSJP_1912"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1912"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003916">
        <property type="term" value="F:DNA topoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003491">
        <property type="entry name" value="Rep_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02486">
        <property type="entry name" value="Rep_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="385" mass="42895" checksum="91706951A0BA1DB2" modified="2017-06-07" version="1">MSSGFTLTIDWLAFTLPRSNRQTVMTVVEGEWSRANSGFRGYPLSWILAPNTRGIGKMGSGRPSDPAEVHVDLSGGIVSSWPAERLQAVLRWVFEEGGHLTRLDCALDDRESSVQVERVKQAVEGGQCVTRAGRFQALYGASMADGAITGQTLYFGSPKSHTMLRVYDKRLEARSKGREDCEQFGVRWELELRKERANACGQALAALPASDWIEYVVSILRGYIDFRDTTREALSVERCRAPLLPWWFTLTEGFAKGRFVLEHAPRTIEDVKRWIRDSVAPMLAVACAAPEAGDAWLTRTIVDSTERWKDRHRRLARGNRGLVRATTVSPQPITQGGLRDNVAVTDSRVLKKASTIKAPYILKTHTNHTTTNNTGHTQGSTDDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I540</accession>
    <name>A0A1W1I540_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48116">
        <property type="protein sequence ID" value="SLM48116"/>
        <property type="gene ID" value="NSJP_1944"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1944"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="212" mass="24397" checksum="01BD0BE62C556BBB" modified="2017-06-07" version="1">MTQETYFKTRFAQDARRDVLWQTLCRYYFNHRIDPDDCVLELGAGYGCFINAVVARRRIAVDSWDGFTAHLVSGVEGHVGDVTDLGFLKPASVNFVFASNLFEHVSQEAFASVLQQLNTALADGGTLNILQPNYYYAYREYFDDYTHRTVYTHKSLCDFLEAHGYTVMECHPRFLPLTVRSRLPVSPALIRLYLSLPWKPMGKQMFIRAMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I584</accession>
    <name>A0A1W1I584_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48160">
        <property type="protein sequence ID" value="SLM48160"/>
        <property type="gene ID" value="NSJP_1988"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1988"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="163" mass="18522" checksum="F7918006F11B9434" modified="2017-06-07" version="1">MSGCPIEWKRTTGRCPIWNRHPVFFIWLPGQDSNLRPAGYKDSLSFERAWTISSPTWVFREGCRALVRRYWVGSSASSLCTFLPTECRSAGFAQDYRSGYTETASLNSPDVSTTVSCGSCKFYSRLLYQLSYRGTVSSFKRTHSSTDDTDEIEGFLERMTQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5A7</accession>
    <name>A0A1W1I5A7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate:ferredoxin oxidoreductase beta subunit</fullName>
            <ecNumber evidence="2">1.2.7.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">porB</name>
        <name evidence="2" type="ORF">NSJP_1993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.1" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1993"/>
    <dbReference type="EnsemblBacteria" id="SLM48165">
        <property type="protein sequence ID" value="SLM48165"/>
        <property type="gene ID" value="NSJP_1993"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1993"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="92"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="300" mass="33136" checksum="55A8B5CA58A128A9" modified="2017-06-07" version="1">MSKERIKISEDLYDIMPSDYQDLVKSATYGKEDRGWKDIGTSKELIEQHSLCAGCPESMAFRYILASLPNPEDTVMVGSTGCTSLVFPMVAVHNIHSLFGNQNAIASGLKRALSVRFPGRVKDVVVLAGDGATVDIGLDMTLQAWFRQEKFTTICFDNELYANTGGQESGLMQKGFVAKMAPVGKLFDKVRLPEIARESGCHYVVNCTVSKPSLVEKVIRNAVHVAREIGPTYLQLYTPCILEIGKNSMEGLQEMRDSEKPTERFAYKEYISEPAKQLLAELAAKDKERKAAAKQLAGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5D2</accession>
    <name>A0A1W1I5D2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FMN_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2040"/>
    <dbReference type="EnsemblBacteria" id="SLM48212">
        <property type="protein sequence ID" value="SLM48212"/>
        <property type="gene ID" value="NSJP_2040"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2040"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012190348" description="FMN_bind domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="2">
        <location>
            <begin position="113"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="225" mass="25431" checksum="A327FF1F99BAB500" modified="2017-06-07" version="1">MTVRTWPFVILLAALLAPSTAWAERIWDAELKRYLTEQEMSHAEVFLTEDDALKLMFPTSERIRKDSIHLTPEKKNQIEERIGWKFPEEGFEVFIGETGTKIDGYAMIQNTIGKHKPMTYMVGVDPTGACTNVELLVFREARGSEVRTKRFNAQYEGKTVSDPIRINRDIINISGATMSVRSFSAGVKRVLVLIDEYYLKPIGLGSDSVAARKAEKGFFGMLFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5E9</accession>
    <name>A0A1W1I5E9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Biopolymer transport protein ExbB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">exbB</name>
        <name evidence="10" type="ORF">NSJP_2048</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2048"/>
    <dbReference type="EnsemblBacteria" id="SLM48220">
        <property type="protein sequence ID" value="SLM48220"/>
        <property type="gene ID" value="NSJP_2048"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2048"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014172">
        <property type="entry name" value="TonB_ExbB_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02805">
        <property type="entry name" value="exbB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="9">
        <location>
            <begin position="51"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM48220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="141" mass="15620" checksum="51A9E95CD63F3C82" modified="2017-06-07" version="1">MDFLKHAVDYGVIGLLFLLSIWCVAVAVERWLFYRRVDLKQYPNQQVFEIALTRRLVIIGTVASNAPYIGLLGTVLGIMLTFHTMGTTGQMAVNTIMIGLSLALKATAVGLLVAIPCVVMNNLLRRRVSELVTLYKVQHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5I1</accession>
    <name>A0A1W1I5I1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">mraZ</name>
        <name evidence="10" type="ORF">NSJP_2092</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MraZ family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2092"/>
    <dbReference type="EnsemblBacteria" id="SLM48264">
        <property type="protein sequence ID" value="SLM48264"/>
        <property type="gene ID" value="NSJP_2092"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2092"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="5"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="78"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM48264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="146" mass="17164" checksum="BE72E432D7AA8440" modified="2017-06-07" version="1">MFAGEYLCKVDEKGRFIVPSPIREQVESEGRAVVFMKGPEQSILIYSIKEWEKVLERSKATLDEDQSRLFMHFVVSEAGTSEIDKTGRILIPGRLRKLVPLDEDQEIILVGLYHRMEVWNPSEWRRYISRSEDRYEQDMSKILNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5I2</accession>
    <name>A0A1W1I5I2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sortase family protein, Peptidase C60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1967"/>
    <dbReference type="EnsemblBacteria" id="SLM48139">
        <property type="protein sequence ID" value="SLM48139"/>
        <property type="gene ID" value="NSJP_1967"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1967"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05828">
        <property type="entry name" value="Sortase_D_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041999">
        <property type="entry name" value="Sortase_D_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022445">
        <property type="entry name" value="Sortase_proteobact_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03784">
        <property type="entry name" value="marine_sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="214" mass="23487" checksum="2CC3C57420AC9665" modified="2017-06-07" version="1">MSDTGVADMAMAAAGILSRRHPLGGWTVILIACLIAAGSWQIGQAVWTYAKAGLAQFLLQRAWSRSLAANEAVPPWPWADTWPVARMTVPSRHRDLIVLNGAYGRTLAFGPGYVESSAFPGAPGTTILTGHRDTHFAFLKQLQLGESLTIHTLDGRTRSYRVTERRIADSRTDRIALDADRQALVLVTCYPFDTPIPGGPLRWIVEAEEDRTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Q1</accession>
    <name>A0A1W1I5Q1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48271">
        <property type="protein sequence ID" value="SLM48271"/>
        <property type="gene ID" value="NSJP_2099"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2099"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="149" mass="15898" checksum="DEBFE55A36010897" modified="2017-06-07" version="1">MSSGEGLPLDCGLPWQAQGALGGHPFSRSASSTCFTGSTWAAGRGVTLLAERFGQEAELECAAEELGDVSDVEAAHQIEPVDFDGADADLQDGGDFTIGMTDGNQPKNVPLTRSERPELDFLHDRLGFATQCAFHVALTIRSRDMLTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5R3</accession>
    <name>A0A1W1I5R3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2162"/>
    <dbReference type="EnsemblBacteria" id="SLM48334">
        <property type="protein sequence ID" value="SLM48334"/>
        <property type="gene ID" value="NSJP_2162"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2162"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="9"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="330" mass="37054" checksum="0B75973EE5CFCA71" modified="2017-06-07" version="1">MEPSGKSLIDCHVHLAALPEGDNGCYISTGMLKSPLFRFLLWKHSLPKDDPREANRKYLDDLLSELTASRHVARAVLLGMDGVYDGSGRLDLPRTDFLIGNDYVLSTARRHPREFLAGVSINPQRRDAVDEIHRCADAGAVLVKVLPNAQQFDPADPAHIPFYRALAERKLPLLSHVGYEFSLIGKDQSLGDPDRLRLALDQGATVIAAHACSYGLMLYEKFLPVLQDFAKRYPQFYADTSALTLPNRFRMLLHLRRHPELHSHLLFGTDYPLSVFHLPAWGRVSLGRLLDIVRTKNRFDRQYTVCRALSVSSRSFGDLLAESQPTTPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5R9</accession>
    <name>A0A1W1I5R9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48344">
        <property type="protein sequence ID" value="SLM48344"/>
        <property type="gene ID" value="NSJP_2172"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2172"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="149" mass="16926" checksum="D8E2164BDFCF1F9A" modified="2017-06-07" version="1">MLSEGVQQVLTVIYPLYKDEVYKRREQMMRLTALGSFGLIAMLFALLLSPQKHRMSSAETVLLGVVGLTWCGLFCALVLQQQYRHRLAKQVLIQIEQALGFYEEGLIVENQTLYPDSWKTAWLGDRSGTFYLSVLSLLTLLLLVALLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5T2</accession>
    <name>A0A1W1I5T2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminopyrimidine aminohydrolase</fullName>
            <ecNumber evidence="1">3.5.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-aminomethyl-2-methylpyrimidine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:31799"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:63416"/>
            <dbReference type="EC" id="3.5.99.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17509"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="EC" id="3.5.99.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TenA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.2" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2178"/>
    <dbReference type="EnsemblBacteria" id="SLM48350">
        <property type="protein sequence ID" value="SLM48350"/>
        <property type="gene ID" value="NSJP_2178"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2178"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050334">
        <property type="term" value="F:thiaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027574">
        <property type="entry name" value="Thiaminase_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04306">
        <property type="entry name" value="salvage_TenA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="TENA_THI-4" evidence="3">
        <location>
            <begin position="11"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="222" mass="25712" checksum="7A70893B009FFF67" modified="2017-06-07" version="1">MSFSDHLRRLAEPIWTAQLSHPFVVALGNGTLHQRKFRYYILQDARFLGDLSRVFAAGALRAPDSDSALRFAKLAEDTITVERSLHENYGTGWKITARAMASVPMAPTNYAYTRHMLAVAASGTAAEIAVVALPCAWIYYVVGRHLLRKGPPPNTHPYRNWLMLYASPEFADVQRWMRRQVDRWAKTAGQEERRRMEESFVISSRYEWMFWEMAWTEEQWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5V9</accession>
    <name>A0A1W1I5V9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2236"/>
    <dbReference type="EnsemblBacteria" id="SLM48408">
        <property type="protein sequence ID" value="SLM48408"/>
        <property type="gene ID" value="NSJP_2236"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2236"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022532">
        <property type="entry name" value="DUF3696"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12476">
        <property type="entry name" value="DUF3696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_15" evidence="2">
        <location>
            <begin position="480"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3696" evidence="1">
        <location>
            <begin position="568"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="625" mass="70345" checksum="88E782F658B7C287" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5W3</accession>
    <name>A0A1W1I5W3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2087"/>
    <dbReference type="EnsemblBacteria" id="SLM48259">
        <property type="protein sequence ID" value="SLM48259"/>
        <property type="gene ID" value="NSJP_2087"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2087"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="233" mass="25622" checksum="F03160DD04D810A9" modified="2017-06-07" version="1">MRSVWMTAIVAAGAFSIMGCVVSDRKYQEAIAEGDAAKTELATMRTQKSALEQQVKTLKELNVKFGNEAQAAHDELERIQHSRDKERGSIEARTKELEDRVRQLTVQNRAMKSEYEDAKRHNETLKSLVARYQKELKERSVTGSLAPSAASPPAMVPAPMPPSTVTPPSAGAGLMNVNKASAGDMVLVLGISKEMADRIVMNRPYKVKGELVAKNVVPKETFDTIRERISVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I608</accession>
    <name>A0A1W1I608_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_2286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2286"/>
    <dbReference type="EnsemblBacteria" id="SLM48458">
        <property type="protein sequence ID" value="SLM48458"/>
        <property type="gene ID" value="NSJP_2286"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2286"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024032">
        <property type="entry name" value="rSAM_paired_HxsC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01103">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03977">
        <property type="entry name" value="rSAM_pair_HxsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="99"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="399" mass="45133" checksum="F3CBC4F4A5DBC540" modified="2017-06-07" version="1">MLKLHGRLPIIQTAANPPYLITVTTDDRVSPEARQTRALLMRQGMNPEGFKAILTDQPYPVTQAQQSDVFQIGEEYAYLNDGDILRLDPASGAIRCLYRRASPNNTILLTEQCDHYCLMCSQPPKQIDDSWLLKEARDLVAMIPPETECLGFSGGEPTLYGQGFIDLLRHTKTSLPKTAIDVLSNGRAFKDMDFAKAYAEVQHPELMVGIPIYSDDAVRHDYVVQSRGAFDETIQGILNLKSLQQRVEIRIVIHRQTVDRLVQTCRFIARNLLFIDHVALMGLEITGFTRPNLDLLWIDPFEYKDVLSEAVTLLNSYGVPTSVYNHQLCTVNPDVTENYRKSISDWKNEYLEECVKCAKRRECGGLFSSSKLYKHSAYITAFPPDSVLPASKPPVNYPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I665</accession>
    <name>A0A1W1I665_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="5">50S ribosomal protein L10</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">50S ribosomal protein L7/L12</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="primary">rplJL</name>
        <name evidence="5" type="synonym">rplJ</name>
        <name evidence="6" type="synonym">rplL</name>
        <name evidence="10" type="ORF">NSJP_2330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2330"/>
    <dbReference type="EnsemblBacteria" id="SLM48502">
        <property type="protein sequence ID" value="SLM48502"/>
        <property type="gene ID" value="NSJP_2330"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2330"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="9">
        <location>
            <begin position="188"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="8">
        <location>
            <begin position="244"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM48502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="311" mass="32985" checksum="C4555F3977FAAC63" modified="2017-06-07" version="1">MKKEEKATAVAELTEKFGRARLAILTECSGLPVNQVTELRKQLRGAKAEYKIVKNTLAARASEGTSVSGLKTHLKGPTGMVIGYDDPVLPTKILRDFIAAEKREEKIRITLGVLEGKVVQAAELAAVAKLPKKEVLIAMLLSAMQGPIRGVVYTLNAVLSKFVRVIAAIQDKRKGEGDMPATEGKLSQDELIKAIESMSVLDLAELVKGLESRFGVTAAAPVAMAAAPAAGGAAAAPAEEKTAFDVILASAPADKKIQIIKVVRELTSLGLKEAKDLVEGAPKPVKNGVTKEEADTMKKKLEESGAKVEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6N0</accession>
    <name>A0A1W1I6N0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2495"/>
    <dbReference type="EnsemblBacteria" id="SLM48667">
        <property type="protein sequence ID" value="SLM48667"/>
        <property type="gene ID" value="NSJP_2495"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2495"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="67"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="301" mass="32345" checksum="DC664088C8E1F55E" modified="2017-06-07" version="1">MTQRPLLLLALPLFLIGCQSTGQSDRGSAKLAVASDHTAAKTAGEVRRRPVPAGGVTLSILEGGTGKPVIFVHGVVTTSNIFPTYLQAYSPAYRGIAVDLRGYGDSEKPSTGFTIKQFSEDLIALANKLSIEKPVWVGVSMGGMILQQLALDHPERVGALVLVSTTDGAMVLDKDLPTIGRQRDYRDVSHNIIVESFPPGTPPALYQPLLDRIPTWNGTVLREALTSMAQANVHGRLHAISAPTLIVVGEKDDVATPAIARGIQSQIAGSKLVEFQTGHFMMAEDPERFRTVLGDFLRSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6X4</accession>
    <name>A0A1W1I6X4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Urease accessory protein UreG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ureG</name>
        <name evidence="5" type="ORF">NSJP_2391</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2391"/>
    <dbReference type="EnsemblBacteria" id="SLM48563">
        <property type="protein sequence ID" value="SLM48563"/>
        <property type="gene ID" value="NSJP_2391"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2391"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="PTHR31715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="4">
        <location>
            <begin position="7"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="212" mass="22991" checksum="B2E4F5C3D67C8F1E" modified="2017-06-07" version="1">MKKITRIGVGGPVGSGKTAIIEAMTPIFVNMGVKVLIITNDIVTTEDAKHVQRTLKGILLEERIIGVETGACPHTAVREDPSMNLAAVEDMESRFPDSDFVLIESGGDNLTLTFSPALVDFFIYVIDVAAGDKIPRKNGPGISQSDILVINKTDLAPYVGASLQVMDKDSKMMRGEKPFVFTNCKTGEGIMDLVTLIQQNVLFDMTFGKTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Z9</accession>
    <name>A0A1W1I6Z9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NSJP_2641</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2641"/>
    <dbReference type="EnsemblBacteria" id="SLM48808">
        <property type="protein sequence ID" value="SLM48808"/>
        <property type="gene ID" value="NSJP_2641"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2641"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="198"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM48808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="466" mass="50789" checksum="761330E62FC5C7FD" modified="2017-06-07" version="1">MSKAWNWIVPHMFGILAALLAGPILGRLASVHAFSIPALSLSGNAAVRLGADVVALALLLSLALNAYREIPDNGRGSSFLRHIVIPLAVLTAIVYGDKAFRGVGLPLVERFGSVRYLWAYTSGIIASGLWLTVAWLSHLGSLREAFCPARHVKRPGQHASADDESGETNLDGVQEEEPQDGSATMLLTGTPPSMLGRYKVLKELGRGAMGIVYLGKDPTIQRFVAIKTMRLDQIDDGTKLQEVKARFFREAESAGRLSHPNIVTIYDAGEQDELGYIAMEVLEGSSLKQWSRPPNLMSVADVVHALTTVAEALDHAHQQGVVHRDVKPANVMLTKDRIVKVMDFGIAKMASSSKTQTDLVLGTPTYMSPEQIAGKKVDGRSDIFSLGVVLFELLTGRPPFIADNLSALLFAIAHQPHPPLNALRKDLPPMFQEVLDRALQKELPQRYRRAGEFARDLRACLQSLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I701</accession>
    <name>A0A1W1I701_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48780">
        <property type="protein sequence ID" value="SLM48780"/>
        <property type="gene ID" value="NSJP_2613"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2613"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010718938" evidence="1">
        <location>
            <begin position="22"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="306" mass="34578" checksum="44D14CDC05603DC2" modified="2017-06-07" version="1">MYLPVRFLTRSLVLVALFALSAGCSPVQPVSVEVMRVPETPCTDNQAIIFCDGFESGTLGLWQDGVDSSRQKVTAVDSDVVSGRRSLEVVYPAGDDGGWMTRWFMPGHDHVFARIYVRFQPGWRCGGNCTKLIAFYANRVDDRWSGFGKAGIRPTGQDYFYAGLATSNWHRQPDPGEIIFYSYHPEMRQAKDGRFWGNFSYQDDPRDALRPGRWYCVEFEVQANSPGQHDGYQNMWIDGMLRGRVSGMRWRDSPDVRINAFQLTFSGAVPVTERMWMDDVVVSTERVGCNRPLVNDTADQAATAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I709</accession>
    <name>A0A1W1I709_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Pytoene desaturase</fullName>
            <ecNumber evidence="2">1.14.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.14.99.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2630"/>
    <dbReference type="EnsemblBacteria" id="SLM48797">
        <property type="protein sequence ID" value="SLM48797"/>
        <property type="gene ID" value="NSJP_2630"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2630"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="9"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="438" mass="48534" checksum="A63C7DCC38AB9F2E" modified="2017-06-07" version="1">MTGPGAQTVLVLGGGPAGLSAAYALVQRGLRVTLLDRAASLGGGFGDERQPPPTLLGCHHATWRLLTALEFPPRSPEFQQTGLEFRLPDERIVRYPHSRFPTPLHSLFTIGRFAGLSWSARWRLLSWLEELWEGSSELGTDLEYRTAQEWLTSLGHDVSLQQAIWNPLAQWLTGNGLRMLSADALAGALAPVFLRRSSDSRIMIPLRSPNVFFVEPILDRLRRSGADVRPETQAMQLLYRQEHVTGVRLRDGTVLEADWYVSAVSYRHLTALLPERWLTRFAYFQQISELTPVPRGVVRLVARQVTQAPRLMLLREGPFQRVQVHPKEDGQNLFTLITTDGQRRQADMGEQATQLLQATGLIRPSTEVSLIGNDEDADSVLSLAPGTKVRRPIQTSPIANLLVAGSWTDTGWPANLESAIVSGERCASIISGTPLTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7P6</accession>
    <name>A0A1W1I7P6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase_M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_2847</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2847"/>
    <dbReference type="EnsemblBacteria" id="SLM49014">
        <property type="protein sequence ID" value="SLM49014"/>
        <property type="gene ID" value="NSJP_2847"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2847"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M48" evidence="7">
        <location>
            <begin position="73"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="499" mass="54363" checksum="232729E0264DB758" modified="2017-06-07" version="1">MTTTSLSHSVRGICSGGLAVVVLLIGSSACTINPVSGWPEFTLVTTGQEKQIGAEEAKKVEEEMGLLDNQALAGYLDQLGQRLAKESPRQNVDYHFYAVDMIEPNAFALPGGYIYVSRGLLALVNSEDELAGVVGHEIGHVAARHSVQKISRQGPFALITNFVSGITGFFVPFVGNVLGGIGNFAQSLVFSPYSRSQESEADKVGQEMAAKAGWNPEGLATFLNTLGREESLLNDGPRRPSFFDSHPATPDRVEKTVKWAKEFKQVQRDPITPTPEAFLKRFDGLVVGQRAANGVIEGREFRHPDLNFFVEFPDQWQVENTPVQLASAPKEGNMGVLVRAVGEGTDPMDGARALEKAVKSPVVEKTHPTTVNGLPAAKAKIGDSKVTADITWIAHGGLIYQLVGITETKNYEAIHPVFQAVTNSFRPLRPSERAGIREKRLRLVEAHAGEKLEALVDRSRSRWTTKQVAVANNLKETDLLRAGQLVKVTMEEPYVGKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7V8</accession>
    <name>A0A1W1I7V8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49112">
        <property type="protein sequence ID" value="SLM49112"/>
        <property type="gene ID" value="NSJP_2945"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2945"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="144" mass="15614" checksum="C60539B56BDEE308" modified="2017-06-07" version="1">MRFIKHHSPCFAGSLNAGLWCAVFMCAILAAPLTASASGLLDLADLISHPEQYDRQEVVVSGEVTNVQLATNRQGQPAYGFLLKDHAGTVKVIGLGQAEVREGDQVIVEGIFTRLRQAGRTIIYNEIKALSIRSLNRLNPDLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I816</accession>
    <name>A0A1W1I816_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="9">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycogen branching enzyme</fullName>
            <shortName evidence="9">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">glgB</name>
        <name evidence="12" type="ORF">NSJP_3005</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3005"/>
    <dbReference type="EnsemblBacteria" id="SLM49172">
        <property type="protein sequence ID" value="SLM49172"/>
        <property type="gene ID" value="NSJP_3005"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3005"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="11">
        <location>
            <begin position="253"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM49172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="735" mass="84634" checksum="D6D99F1365F6C34A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I819</accession>
    <name>A0A1W1I819_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2779 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2979"/>
    <dbReference type="EnsemblBacteria" id="SLM49146">
        <property type="protein sequence ID" value="SLM49146"/>
        <property type="gene ID" value="NSJP_2979"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2979"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021301">
        <property type="entry name" value="DUF2779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11074">
        <property type="entry name" value="DUF2779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2779" evidence="2">
        <location>
            <begin position="312"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="519" mass="57951" checksum="87D3724BC95172E4" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I841</accession>
    <name>A0A1W1I841_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3003"/>
    <dbReference type="EnsemblBacteria" id="SLM49170">
        <property type="protein sequence ID" value="SLM49170"/>
        <property type="gene ID" value="NSJP_3003"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3003"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010275">
        <property type="entry name" value="DUF882"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37425">
        <property type="entry name" value="PTHR37425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05951">
        <property type="entry name" value="Peptidase_M15_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="187" mass="21237" checksum="A8E94D56AFB21014" modified="2017-06-07" version="1">MSDQDWLWTRRALLKTSLVGLLAVSGRVFSPSTSQAATLPEGELDFYNVHTDERLHVRYRNELGEYDLAALDEVNHVLRCHHTGEVAAMDIRLLEHVNLVQKTLGGNGEIHVISGYRSPEYNALLVKRSRRAVRHSYHIEGQALDFYIPGTPLRAIRQVARTLRYGGVGFYPRAGFVHLDCGPVRFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I866</accession>
    <name>A0A1W1I866_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Oxidoreductase, DsbA-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3027"/>
    <dbReference type="EnsemblBacteria" id="SLM49194">
        <property type="protein sequence ID" value="SLM49194"/>
        <property type="gene ID" value="NSJP_3027"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3027"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041205">
        <property type="entry name" value="ScsC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18312">
        <property type="entry name" value="ScsC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012845473" evidence="2">
        <location>
            <begin position="23"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="33"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="256" mass="27830" checksum="29544EEA8C43CFCB" modified="2017-06-07" version="1">MTQVCAQVSPFCRLTLLLLAVAVTGCTSLNDSSAVPNPASQQTLDKAIEQYIRAHPEVIEQSLQELETKRETAERARQKVALANRQKELLHDASSPVSGNPNGQVTLIEFFDYRCGFCKRAAGAVTQLQKEDPSVRVVYKDFPILGEPSELAAKAALSANAQGKHQAFHEALLATKNEMTRDELLRVAGEVGLDAKRLDTDMANPEWQTVIDRNRALARELGISGTPGFIVGTELVPGALDVKGLKDLIARVKDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I877</accession>
    <name>A0A1W1I877_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49217">
        <property type="protein sequence ID" value="SLM49217"/>
        <property type="gene ID" value="NSJP_3050"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3050"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="125" mass="13770" checksum="3A4C9B043FFF73D5" modified="2017-06-07" version="1">MPDPRSHTRIPVRVSGCFAYGSGGWIDGIVVDLSAAGCCLETRTRIQPPSFLQLILTASAEDLPISIDLAVVRWVKEGKIGVRFLSLQAEQHKRLHCLLVGDRHTHDIPCLSRMPETARLSAENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8D6</accession>
    <name>A0A1W1I8D6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3097"/>
    <dbReference type="EnsemblBacteria" id="SLM49264">
        <property type="protein sequence ID" value="SLM49264"/>
        <property type="gene ID" value="NSJP_3097"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3097"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070122">
        <property type="term" value="F:isopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="4"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="171" mass="19150" checksum="B7AA36E7DA6D8CFC" modified="2017-06-07" version="1">MPDLIIPQSVLDELVEHARTLDPYECCGFLAGTGQTVSRVYRIKNVVSLEGAADAAAFDEAKIQHLSRLSPEERAEIAFIMDAREMFQAVKDIRNSGLTLQVVYHSHPHDPARPSVTDIKIADDWEENWARLNLTLPLYLLISLQDKARPDIRAYRISQGRVTPATLSPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8F5</accession>
    <name>A0A1W1I8F5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nadC</name>
        <name evidence="13" type="ORF">NSJP_2972</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2972"/>
    <dbReference type="EnsemblBacteria" id="SLM49139">
        <property type="protein sequence ID" value="SLM49139"/>
        <property type="gene ID" value="NSJP_2972"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2972"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="12">
        <location>
            <begin position="23"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="11">
        <location>
            <begin position="112"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="133"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="245"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="266"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM49139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="292" mass="31261" checksum="1EF1AAABDA093228" modified="2017-06-07" version="1">MVALPAADIRRAVRLGIAEDLSQGDVTTSALFSTRIQARARIVAQEDLVVAGMTPAVQTFLAVDPSLKLSVVKRDGTAARSGEVLITITGDGRSILMAERVALNFLQHLSGIATLTHRFCRAVQGYPARIMDTRKTLPGWRAIQKWAVALGGGINHRKSLGDGLLVKDNHLALLGVKREPVLRACLAVKSGSRVARPLIVEVESLRDVKEALRGNAEIILLDNMTVTDVRKAVRLIDGRALVEISGGITLKNVRAMAATGADRISIGALTHSAPAATLTLELKAVSRPKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8S1</accession>
    <name>A0A1W1I8S1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin reductase carring response regulator receiver domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
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            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="SLM49406">
        <property type="protein sequence ID" value="SLM49406"/>
        <property type="gene ID" value="NSJP_3239"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3239"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="552" mass="60372" checksum="4445482E6140BD87" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8U2</accession>
    <name>A0A1W1I8U2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative PEGA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49426">
        <property type="protein sequence ID" value="SLM49426"/>
        <property type="gene ID" value="NSJP_3259"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3259"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013229">
        <property type="entry name" value="PEGA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012461436" evidence="1">
        <location>
            <begin position="23"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="PEGA" evidence="2">
        <location>
            <begin position="34"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="134" mass="14490" checksum="5669AAF6D2B7492B" modified="2017-06-07" version="1">MNFAMCAWKTTCVGLALCTLLAGCGSIIHGSRQTVSFDSTPAGAIVKLQNGTSFTTPHSEELRRAEEHTVTIEKDGYEPARIAIKRDFNGVATILGNILWLIPGVIVDVLVGGAWTLDPEHVNVQLVEQKTKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9G8</accession>
    <name>A0A1W1I9G8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49571">
        <property type="protein sequence ID" value="SLM49571"/>
        <property type="gene ID" value="NSJP_3404"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3404"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="147" mass="16257" checksum="2194121BC8B18CE7" modified="2017-06-07" version="1">MSTCSVAVTAMMVNPFLVSRETGRSEEHFHVRAVDFDLIDFDLPRRIVHTGSGGDVELPTMPRAGHHLAFHVTFAERPSAVNAGIIDGVKHPVDIEEGNGLPLRFRYDSVAWLNIPASRHPYELSHGSPSPSVTLSLLAERFFDLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Z7</accession>
    <name>A0A1W1I9Z7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49812">
        <property type="protein sequence ID" value="SLM49812"/>
        <property type="gene ID" value="NSJP_3645"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3645"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="94" mass="10523" checksum="E169F9BDC0929506" modified="2017-06-07" version="1">MGCNTGRDRPQRTGQEPIGSPMLDAPPWPPTQVPLKRRGRDATLPLIFWSSKPGARQEGRLAAWDLMDMVKSDPSFANDSRQRADPEHKAVDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA05</accession>
    <name>A0A1W1IA05_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3687"/>
    <dbReference type="EnsemblBacteria" id="SLM49854">
        <property type="protein sequence ID" value="SLM49854"/>
        <property type="gene ID" value="NSJP_3687"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3687"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="144" mass="16346" checksum="2E420D20D03D21BD" modified="2017-06-07" version="1">MILNIDHVTIVVRDLAEAKAFFGLLGFVQDKSVVISGDRFSRYMGVPQIEAEHVTLVSAQKPRFEIQLLRYLKPEQLAETDVKNLAKPGFNHICFAVTDLDGEVRRLVDRGVVLRNEVMDFHDRKLVFLSGPEGITVELAEWHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA21</accession>
    <name>A0A1W1IA21_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3668"/>
    <dbReference type="EnsemblBacteria" id="SLM49835">
        <property type="protein sequence ID" value="SLM49835"/>
        <property type="gene ID" value="NSJP_3668"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3668"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="58"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="554" mass="62300" checksum="8B5B98DF740ECDFF" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA34</accession>
    <name>A0A1W1IA34_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49884">
        <property type="protein sequence ID" value="SLM49884"/>
        <property type="gene ID" value="NSJP_3717"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3717"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="89" mass="9892" checksum="9F7350693E94DA6D" modified="2017-06-07" version="1">MSADLFPGKTRPFYWLQSVESTVQREGRPVSGRTGNERGITPTNDFPGGSTGVHSRTWRGRRDRPACVERRYRPDLSPGNCLPSNSSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA78</accession>
    <name>A0A1W1IA78_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HD-GYP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49906">
        <property type="protein sequence ID" value="SLM49906"/>
        <property type="gene ID" value="NSJP_3739"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3739"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="2">
        <location>
            <begin position="248"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="520" mass="57177" checksum="D10EFA9574D9D67A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA84</accession>
    <name>A0A1W1IA84_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49905">
        <property type="protein sequence ID" value="SLM49905"/>
        <property type="gene ID" value="NSJP_3738"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3738"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="598" mass="65198" checksum="780250C93E906DB2" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA91</accession>
    <name>A0A1W1IA91_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3664"/>
    <dbReference type="EnsemblBacteria" id="SLM49831">
        <property type="protein sequence ID" value="SLM49831"/>
        <property type="gene ID" value="NSJP_3664"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3664"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="191" mass="21039" checksum="99672937B522DA8A" modified="2017-06-07" version="1">MTRQMVFLRPRYFSGQLLTAEDLATEQDYHRAIQRFRNLYTHGYGIVSGLSVQTGGNGTSVTVEPGYAIDGFGREICVPTALTLSLPDDAKRLAVCVGHAESETGPIAVAGTPPGIDLPVDPSRIEEGFDIAFRQIPPGKLNHAQIVAHLQGASREWILLAILRRDGKRWRRAPLATKPHSKSQSTLRRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAE0</accession>
    <name>A0A1W1IAE0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3714"/>
    <dbReference type="EnsemblBacteria" id="SLM49881">
        <property type="protein sequence ID" value="SLM49881"/>
        <property type="gene ID" value="NSJP_3714"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3714"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="18"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="102" mass="10797" checksum="522FDDA860C9ECFC" modified="2017-06-07" version="1">MYDIKNLGRLKQLEVLAPETAKAFWTFDKAAWADGAIPKKYKELMAIALALTTQCPYCIELHTNKARESGASDAEIAEAILAAAALRAGGAVTHGTHALAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAM4</accession>
    <name>A0A1W1IAM4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50040">
        <property type="protein sequence ID" value="SLM50040"/>
        <property type="gene ID" value="NSJP_3873"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3873"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012822708" description="Fibronectin type-III domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="39"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="134" mass="13978" checksum="524311A444DE8A54" modified="2017-06-07" version="1">MTTLLPTSGFPFRTVQAVLLSLMPAALSACGQGGGNTMGAVPDTGGSVSSLSVTLAWDPVPDPAVTGYIIHYGRSSPNQRGSCRYEASLFVSQPKGTVHNLRPETRYYFSVSSYNGVEGSCSEEVSTITPASPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB16</accession>
    <name>A0A1W1IB16_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Methylase involved in ubiquinone/menaquinonebiosynthesis-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49963">
        <property type="protein sequence ID" value="SLM49963"/>
        <property type="gene ID" value="NSJP_3796"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3796"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="65"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="238" mass="26643" checksum="A27AB5653B195BAE" modified="2017-06-07" version="1">MDLQEMQSSMDRLGKTEPLLAMLPASLRGRLSKLDEYFSFGLSETDHLIMYISSLGIKLNHNRALDFGCGLGRSTQALAKYFDQVFGIDIAPSIINIAKAHNRHGSKCQYLLNLTNDLRGFETGSIDYICSMGTLYLMEPAFAKNYLKEFLRVLAPGGALIFQLPAEPATTVKGFAFRIIPPSWVNRYRRAKYGFEVHSMTRFEVVSIVEQAGGTLIDVREDSTVGANWTSFQYCVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB84</accession>
    <name>A0A1W1IB84_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="12">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 17" type="primary">metG</name>
        <name evidence="17" type="ORF">NSJP_4095</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="12"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4095"/>
    <dbReference type="EnsemblBacteria" id="SLM50262">
        <property type="protein sequence ID" value="SLM50262"/>
        <property type="gene ID" value="NSJP_4095"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4095"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02800">
        <property type="entry name" value="tRNA_bind_EcMetRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01228">
        <property type="entry name" value="Met_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004495">
        <property type="entry name" value="Met-tRNA-synth_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="PTHR43326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00399">
        <property type="entry name" value="metG_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="569"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="518"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="12">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="12">
        <location>
            <begin position="300"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SLM50262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="669" mass="74934" checksum="9D34AA1475CB2D9D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBB3</accession>
    <name>A0A1W1IBB3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rffH</name>
        <name evidence="6" type="ORF">NSJP_4125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4125"/>
    <dbReference type="EnsemblBacteria" id="SLM50292">
        <property type="protein sequence ID" value="SLM50292"/>
        <property type="gene ID" value="NSJP_4125"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4125"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM50292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="273" mass="29883" checksum="4B1F3CF5239AC09B" modified="2017-06-07" version="1">MPPARADKWAGFFARNVGELSDEGGIMRGVVLAGGLGTRLLPLTKVTNKHLLPVFNRPMIYYPIQTLANAGIDEIMLVTGGNSAGDFLKLLGNGKEFGLKRLNYTYQEGEGGIADALRLAEHFADGEEVCVILGDNIIEGNIAAAARAFREQRKGAKILLKEVKDPQRFGVPVLEGRRVLRIEEKPVSPSSPYAVTGIYFYDAGVFDIIKTLKPSGRGELEITDVNNAYIRTGTLTWDVLEGWWTDAGTIESLHQAHQLVSRTGANKMERIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBG3</accession>
    <name>A0A1W1IBG3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-1-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfbF</name>
        <name evidence="2" type="ORF">NSJP_4062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.33" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4062"/>
    <dbReference type="EnsemblBacteria" id="SLM50229">
        <property type="protein sequence ID" value="SLM50229"/>
        <property type="gene ID" value="NSJP_4062"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4062"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047343">
        <property type="term" value="F:glucose-1-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02524">
        <property type="entry name" value="G1P_cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013446">
        <property type="entry name" value="G1P_cyt_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47183:SF1">
        <property type="entry name" value="PTHR47183:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02623">
        <property type="entry name" value="G1P_cyt_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="257" mass="29317" checksum="3EAB3704CA349CED" modified="2017-06-07" version="1">MKAVILAGGLGTRLSEETIVRPKPMVEIGGKPILWHIMKIYSAHNITEFVICCGYKGYIIKEFFANYFLHTSDVTFDVQSNKMEFHRSSAEPWKVTLVDTGDHTMTGGRIKRVREYIGNETFCLTYGDGVSNVNLGRLISFHKAQRTFATLTAVQPPGRFGAFSLPDKETKIHNFREKLKGDGAWINGGFFVLQPDVLDYIRGDSTVWEEEPMRQLADEGMLSAYKHHGYWQNMDTLRDKSVLEDQWQSGKAPWKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZM9</accession>
    <name>A0A1W1HZM9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Depupylase</fullName>
            <ecNumber evidence="2">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dop</name>
        <name evidence="2" type="ORF">NSJP_0046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0046"/>
    <dbReference type="EnsemblBacteria" id="SLM46218">
        <property type="protein sequence ID" value="SLM46218"/>
        <property type="gene ID" value="NSJP_0046"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0046"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022366">
        <property type="entry name" value="Pup_deamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03688">
        <property type="entry name" value="pupylate_PafA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="499" mass="56122" checksum="3C9D194B6B858FF4" modified="2017-06-07" version="1">MADANAPSTPRVLGTETEFGIASRDAALSDPITNSLAVIGHYPGLSVPHAVWDYENENPLLDARGFEVDGERERPNPDYNRQLNKVLANGGRLYVDGAHPEYSTPECTNAREVVAFERVAERILAQCLDAMTKARGREQIVLYKNNSDGKGNSYGYHENYLVSRSVPFERLVQVLAPFFVTRPIFAGAGKVGAENQTSPADYQISQRADFFECLVDLNTMVKRPIVNSRDEPHCEYAKYRRLHVIVGDANMAELSTYLKVGTLAIVLDLVEAGADLPKFELEDPVRAIKQVSRDLTIKEPLRLAGGQATTALAMQRGYLKAAMDFYACHDLPQVTKDVLVRWEEVLDKLERDPRSLVRELDWVAKRHLMESYMERKGCGWNDPRIRLMDLQYHDVRPDKGLYYTLERSHMVERIVQDVEISRAEFMPPSGTRAFFRGRCVGKYAKSIYGASWTSVLFDLGNTTIKKVPLMDPLRGTEALTADLLEQSDSAEALLEKLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZT8</accession>
    <name>A0A1W1HZT8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Oligoendopeptidase F</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_0089</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0089"/>
    <dbReference type="EnsemblBacteria" id="SLM46261">
        <property type="protein sequence ID" value="SLM46261"/>
        <property type="gene ID" value="NSJP_0089"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0089"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3_N" evidence="8">
        <location>
            <begin position="123"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="207"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="599" mass="68112" checksum="10F0927607D5368B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZX3</accession>
    <name>A0A1W1HZX3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Nitrate reductase, gamma subunit</fullName>
            <ecNumber evidence="8">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_0112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.7.99.4" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0112"/>
    <dbReference type="EnsemblBacteria" id="SLM46284">
        <property type="protein sequence ID" value="SLM46284"/>
        <property type="gene ID" value="NSJP_0112"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0112"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019020">
        <property type="entry name" value="Cyt-c552/DMSO_Rdtase_haem-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09459">
        <property type="entry name" value="EB_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00887">
        <property type="entry name" value="EB_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="EB_dh" evidence="7">
        <location>
            <begin position="56"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="317" mass="34365" checksum="E0CA10FEEC6F21D3" modified="2017-06-07" version="1">MRVVQTHNKSVVFGILLSALIVGVMLTIGQVPLAVSQPVTIPAKAVKGPIPMDGANPLWESVPGVIVPLSGQLITTPMHPNISVKSVFVKSMTNGKELGLRVEWSDQTKNDTTIGPQDFRDQVAIMFPVNTSGAPPFQCMGQSGGTTNIWRWNAEWQKDLGKDSAGIWDVDDQYPGIFWDYYFEEPAGGVTYPDRIGRSLGPFNPGIWSGNIMSDPTLRVSSVEDLNANGFSTLTTQAHQDVIGNGVWEPSGSVKGGGYTGPTWRVVVKRTLETGDANDTQFKAGMSVPIAFAVWDGNNIERNGMKALSTWFTLKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZX8</accession>
    <name>A0A1W1HZX8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0136"/>
    <dbReference type="EnsemblBacteria" id="SLM46308">
        <property type="protein sequence ID" value="SLM46308"/>
        <property type="gene ID" value="NSJP_0136"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0136"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="70"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="305" mass="34464" checksum="8EBF4D21A77AC24C" modified="2017-06-07" version="1">MENRGVLIGSIIFVFASFFLMIGMMLWESNKAYKMKEMAKSIKTESQPTASAGPAQDYSMYKTRIGDEGREMVHIPEGPFMMGSKDGDPDEAPEHQVFLKEFYLDRNEVTQDEYARFAKMTRRALPRIEVFEDDQSKLLKPEFAAMSVSWDDANAYCKWAGKRLPTEAEWEKAGRGEGKRKYPWGEAFVTGRANVDGSEDGYRYLAPPGSFESGRSPYGLHDMTGNVAEWVADTYDENYYKKSPYRDPKGPENGDLKVVRGGSWRETEHNTRLSKRFAAKHWRTDITIGIRCASDADAGGNSSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZX9</accession>
    <name>A0A1W1HZX9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0017"/>
    <dbReference type="EnsemblBacteria" id="SLM46189">
        <property type="protein sequence ID" value="SLM46189"/>
        <property type="gene ID" value="NSJP_0017"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0017"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010415">
        <property type="entry name" value="LpxI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043167">
        <property type="entry name" value="LpxI_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041255">
        <property type="entry name" value="LpxI_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06230">
        <property type="entry name" value="LpxI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17930">
        <property type="entry name" value="LpxI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LpxI_N" evidence="2">
        <location>
            <begin position="12"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="LpxI_C" evidence="1">
        <location>
            <begin position="145"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="287" mass="31217" checksum="296F840B821B3D20" modified="2017-06-07" version="1">MTKTPELHNGERLGLIAGNGRFPIIFADNARKLGYQISAVAHEGETDPALADHVDRIHWIKIGQLNKLIKAFQGDQVRQAVMLGGIKKTHVFTTVRPDFRALALAARLALWKDDDILREIAKELEQEGITICESTFGLDGILAEAGTLTKRKPDSKQWEDIRYGWDVAQQIGLLDIGQCVVIKDRVVVAVEAVEGTDEAIKRGGQLAKEGAVVVKRCKPQQDLRFDLPAVGPRTIEVMASVKASVLAVEAGRTILLDREEMLQQAQKSRIAVVGLSTAGSNGGGQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I031</accession>
    <name>A0A1W1I031_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NodU/CmcH family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0172"/>
    <dbReference type="EnsemblBacteria" id="SLM46344">
        <property type="protein sequence ID" value="SLM46344"/>
        <property type="gene ID" value="NSJP_0172"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0172"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031730">
        <property type="entry name" value="Carbam_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038152">
        <property type="entry name" value="Carbam_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003696">
        <property type="entry name" value="Carbtransf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16861">
        <property type="entry name" value="Carbam_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02543">
        <property type="entry name" value="Carbam_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbam_trans_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_C" evidence="3">
        <location>
            <begin position="400"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="580" mass="64037" checksum="54FDAE665DD62ADB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I049</accession>
    <name>A0A1W1I049_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46371">
        <property type="protein sequence ID" value="SLM46371"/>
        <property type="gene ID" value="NSJP_0199"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0199"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="54" mass="5831" checksum="BC1FFC4911C2F740" modified="2017-06-07" version="1">MAKTATYCSDCYNKVGRTEDAQIQAAEKSGQIPMTGQGTCCKCSKATVVVFYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0D0</accession>
    <name>A0A1W1I0D0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0255"/>
    <dbReference type="EnsemblBacteria" id="SLM46427">
        <property type="protein sequence ID" value="SLM46427"/>
        <property type="gene ID" value="NSJP_0255"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0255"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="374" mass="43442" checksum="BCC6E4923671CA7A" modified="2017-06-07" version="1">MEVNILSTLRRYYCDELHVMHYPGGMGNLGSKAWRTTREELNERLIRLALALKKDGRLDLMFFMVYDDFLLVETARRLAELNVPMVNYHVDMAFQWYRIIRTAPYFHVLAVAQKTNAEHLAFYNSNIEWMPMAANPEFCLEHASSRGYEHGISFVGSFNPFRRALLADCVRHGFKPTVYGRGWNGSSVSPYRFDWDAYKVVHDLWFYAVPRWKAEGAQSLTGALRRKWSRSVAFDELPGPEFRPPCTDEALPAIFRSSKINLGFSDTGWHGNDAVVPSRNLQCRLRDFEVPMAGGFYLVQEAPDHAEYFKPGEEIETWSEPEELIDKLSYYSSNIAAAERIREAGHRRAMSSHTWRHRFDRLFHRVQQRGLLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0D6</accession>
    <name>A0A1W1I0D6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46451">
        <property type="protein sequence ID" value="SLM46451"/>
        <property type="gene ID" value="NSJP_0279"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0279"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="109" mass="12303" checksum="ABC14D0C99477816" modified="2017-06-07" version="1">MSTTPINGTKSWMRIPDGTRVRLCEGGQEGVIDGLTELVVGPARNPDGRTQYRLNVGDQERMLVTQEALFLLTDADGIVLMQKQNIDYRRIVTERLRTELTADRFVRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0H3</accession>
    <name>A0A1W1I0H3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46477">
        <property type="protein sequence ID" value="SLM46477"/>
        <property type="gene ID" value="NSJP_0305"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0305"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="293"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="369" mass="42451" checksum="E2FE63040C3F0C06" modified="2017-06-07" version="1">MNRLTHHSTRQALEFLRELYVLRSWDALTTHIVESIPTLIPTGICSYNEMSSRRRHATYKMWPANRTMIPDAPEILGLYSHQHPLVTHMERTKDFRSQKITDFLSQRQFRTTELFNELYRPLQIPYNMAAGLALDRNCLVALALNRDGKDFTPDELAILELLRPHVRQAFANASTVTSMLEELSALNRAMEEIDRALLAFTEEGRIQWATSRTRRMMKEYGFPCQRPSKWLPSPLREWTKSALEKLNRSSDFPSALQPLIIAKGDRSLIIRLVRDGIRLLLFFDEVSAECSVEELESLGLSRRETEILSWVVQGKTNPEIGAILSISSRTVQKHLEHIYNRLGVENRHAAIITSMAVLRRERAGCIAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0K3</accession>
    <name>A0A1W1I0K3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46514">
        <property type="protein sequence ID" value="SLM46514"/>
        <property type="gene ID" value="NSJP_0342"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0342"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="256" mass="28930" checksum="3147A98CA134B398" modified="2017-06-07" version="1">MSLPRNEGATRHGRLQSVRRAWTHRAAAGSFALCLAGLSLLPADFGGTAHAEGPCTCNDLDKLQAQLDRTTKSEEIWKEIFAWARGLHRDVNLPQSNDDLNQKFVQLTGAPASQWRDLIKQGPAQEKKTLKKVAGLSKEGETVLDEDFKKSNCDDIIDAEHVHEQAHRDFYLSFPQILEAGMSSRLLRLRAESEVEAYRAHKTFLEKKLSDLKLKCLTKLDKSTKMILEQAYAQRERLNQAEQRLRMYGNSEAALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0M4</accession>
    <name>A0A1W1I0M4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AcrB/AcrD/AcrF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46541">
        <property type="protein sequence ID" value="SLM46541"/>
        <property type="gene ID" value="NSJP_0369"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0369"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="499" mass="54844" checksum="459A7FB31BC11355" modified="2017-06-07" version="1">MNQIVLIALRRPYTFVVMSILIVLWGTKTLLHMPTDVFPNITIPVTSVVWIYSGLLPQQVEGRITYLFERFLTSTVEGIKYIHSHSYYGSSITNIFLQDGVDVGRAEADIVGIAQNVVKALPPDISPPMVMRLAPSSIPVAMLQISSDRMTPAELYNLAYMRIRPLLVTVPGIVLPHPYGGQDMQVMVNLDQQKLLARNLTPTDVHNVLMKQYLVLPSGDIKIKSTDWIVQTNASPLQIDHFPDIPIKRDGNAFIYLRDVATVQLMGRVQQNAVLVNGKQTVIIVAMKSTEASTLDVVDGIKKMIPRAEQISPEGVKIRLLDDASTFVKDSIFDVVHEMATAGALVGLIVLLLIGSWRATVIVWTSIPLSILTAIIGLHWLEETINVMTLGGLALAVGILVDDATVMIENIDRHIEMGKPLEQAIIDAANQIVVPTLVATLCIAIVWIPLFELGGVAGYLFKPMAEAVIIAMMASFILSRTLVPTMAKYLLKSHHVEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0R7</accession>
    <name>A0A1W1I0R7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c, class I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_0297</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0297"/>
    <dbReference type="EnsemblBacteria" id="SLM46469">
        <property type="protein sequence ID" value="SLM46469"/>
        <property type="gene ID" value="NSJP_0297"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0297"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="61"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="178"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="289"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="546"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="680" mass="74626" checksum="1299DB6F3724F78A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0T3</accession>
    <name>A0A1W1I0T3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LPG_synthase_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_0420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46592">
        <property type="protein sequence ID" value="SLM46592"/>
        <property type="gene ID" value="NSJP_0420"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0420"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016732">
        <property type="entry name" value="UCP018688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41373">
        <property type="entry name" value="PTHR41373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="LPG_synthase_C" evidence="7">
        <location>
            <begin position="240"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="501" mass="55326" checksum="A940F3FDF5BF8F4D" modified="2017-06-07" version="1">MAASTAQTGSSAESVRSVPQVVPSSTCLQCDVCCRFPDPDSPLRPYFTAEEIVRAVTEGANPDRFPSPRGCQITLIPDQEGDGFHCPAFDPASARCLIYDRRPFDCQLYPLALMWNEHHDDVVLGWDSKCPFMGEQVPDSIRRYADQAMIRLNDSDLLRTVADHPRLIGRFQPDVVELFRLPALTRAVQTRWGATPVHRLTLEDVQRVTDALDESGLAGGQALAAYSVPSIYLCTTLLGYWWAELRGSLCLFAESPDGWFMPLPPLGGGPIQEAIGAAFDLMRRRNGAGSPVSRIDNISPALAARLEVLGYRLQAGEADYLYRAGDLATLTGDRFKSHRALCNKVERLEQVAAASYALRDRAECRRLFQRWQEQKQAGALDSFGRLLLEDAASTHEIAWAHGSDLGLSGTVVRVEGEIRAYTFGCWLSPATWCVLLEVADRSIPGLAQYLFRETCRAAASHGAEFINTMDGAGLAGLSRSKDSYHPVMRIRQYSLLEDHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Z6</accession>
    <name>A0A1W1I0Z6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0504"/>
    <dbReference type="EnsemblBacteria" id="SLM46676">
        <property type="protein sequence ID" value="SLM46676"/>
        <property type="gene ID" value="NSJP_0504"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0504"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="370" mass="41954" checksum="6569D028347C3C18" modified="2017-06-07" version="1">MGTADQSSVVITKGTCYAIFAYDIGSSINLDEADRRITAGTERGRLRHKARAPQYFEYRPAPLRLMQEGGTLTVANYSSSPTFEVMVYDFGAVTITYRFALDGPFDNLLELSEALYEHEQLLTESRARVEQLIQTIHPAVERPRIATEVEDYLIFEINACTSQDIPLWVSREAELARILRGERTPLSDQEIHDAVSCRISFGTDDAALIDWHSAVLFGRDMDDVRAVLEFANVELMEMRMLDEQLDQSLDQGYEALSRKPRLLSLPGSYDKDTTLIAQLQVDGALLFERVTNTLKLLGDQYLARVYRLASQRFHLEDWDASILRKLETLESIYGKMSDRAGTRRMELLEWIIIVLITVSIAVSFVPIGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I112</accession>
    <name>A0A1W1I112_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DHHA1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46690">
        <property type="protein sequence ID" value="SLM46690"/>
        <property type="gene ID" value="NSJP_0518"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0518"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="224"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="296" mass="32503" checksum="5729857B4FBA1682" modified="2017-06-07" version="1">MLRVAMAGPGSTPRASFVPTAILYHAECADGFGAAWALWREFPSARYLPVKHGNPPPDGLSGQRVVIVDFSYSRRQLEAMAGTTESLLVLDHHVTAEKALEGLPYAYFDLTKSGAVLAWEWASSKPVPWLLEYIQDKDLWTWTLPASREINAAVASYPFDFETWNHFSRKDLEHEGRAILRYEGEIVSKLSAQAVMVAFHGETVPSVQSAVLTSQIGERLSADHPFCLIWHDRDGRRYYSMRSKEDGADVGSIAASFGGGGHTHAAGFSIPLGSDGSLPDNPALPRPLLNRRRGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I147</accession>
    <name>A0A1W1I147_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LAO/AO transport system ATPase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">argK</name>
        <name evidence="4" type="ORF">NSJP_0554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0554"/>
    <dbReference type="EnsemblBacteria" id="SLM46726">
        <property type="protein sequence ID" value="SLM46726"/>
        <property type="gene ID" value="NSJP_0554"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0554"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="58"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="268" mass="27984" checksum="5D6B130CB26A320D" modified="2017-06-07" version="1">MTALDLRRSGRETTDVAVLADRVKTGDVRAVSRLITLLENRDPDGAAALRLLDSGSRHADVTGITGYPGAGKSTLIAQLAAAYRRSGRTVGVLAVDISSIVTKGALLGDRIRMGDHTLDHGVYIRSMAARGHHGGLAPTTREAALVLDAAGYDVVLVETVGVGQGEIEIMDVAHTVVAVVAPGLGDEVQAMKAGLLEVAPIIVLNKGDHAGANSTLRDLRAWCPHVVRTVATTGEGIPELVAAIAAHRRSHKTHDDGTPGARPKPRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I153</accession>
    <name>A0A1W1I153_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">prpC</name>
        <name evidence="8" type="ORF">NSJP_0558</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 7">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0558"/>
    <dbReference type="EnsemblBacteria" id="SLM46730">
        <property type="protein sequence ID" value="SLM46730"/>
        <property type="gene ID" value="NSJP_0558"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0558"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011278">
        <property type="entry name" value="2-MeCitrate/Citrate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01800">
        <property type="entry name" value="cit_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="399" mass="44395" checksum="92C0F7A0801344F1" modified="2017-06-07" version="1">MSNGIVAFIRRKTAMRIAESENTPGYSPGLDGVIAGETALCHVDEDEGGLRYRGYAVSDLADQATFEEVAHLLLCGTLPTRKELKEFEGRLAAEALLPAPVEAFLGMIPPAAHPMDILRTSVSLLGMIETDAEDHSHDANLRKSIRLLAQIPLVISVAHGLANGTPRMEAQPNLTFAENLLCLLTGRRGGEEWRLMAHVLDVSLTLYAEHEFNASTFAARATASTMTDLHSAVTSAIGTLKGPLHGGANEAVAEMFLEIERPDRAEGWIREQLGGKRRIMGFGHRVLKNGDSRSAIIQRHADRLSRTCRDRRWYDIALIIERVMRQEKGLCPNLDFYTAVAYLLMGIPRRLYTPIFVCSRITGWCAHVIEQQDHNRLIRPRALYKGPARESYVDIDHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I192</accession>
    <name>A0A1W1I192_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="SLM46770"/>
        <property type="gene ID" value="NSJP_0598"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0598"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
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        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="14"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="76" mass="8660" checksum="A7F558DA990B669C" modified="2017-06-07" version="1">MALTAETTPITRRLLSIQDVAVYTGLSVHTLYAMVSKRRIPHIKLGRLTKFDRVEIDKWIASKSVKVHRPFQVLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1D7</accession>
    <name>A0A1W1I1D7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46815">
        <property type="protein sequence ID" value="SLM46815"/>
        <property type="gene ID" value="NSJP_0643"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0643"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="61" mass="6813" checksum="CA16A10F9A8EE4BE" modified="2017-06-07" version="1">MAYLPSALSSVRQVVQDYLRSADHLIASLVNDGIPLTEREREMVETCLKDLSKLVVPTPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1J1</accession>
    <name>A0A1W1I1J1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nif-specific regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nifA</name>
        <name evidence="8" type="ORF">NSJP_0706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0706"/>
    <dbReference type="EnsemblBacteria" id="SLM46878">
        <property type="protein sequence ID" value="SLM46878"/>
        <property type="gene ID" value="NSJP_0706"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0706"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="GAF"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
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        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="198"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="523" mass="58127" checksum="9818D44074EFBA24" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1V9</accession>
    <name>A0A1W1I1V9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Glutathione-regulated potassium-efflux system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_0802</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0802"/>
    <dbReference type="EnsemblBacteria" id="SLM46974">
        <property type="protein sequence ID" value="SLM46974"/>
        <property type="gene ID" value="NSJP_0802"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0802"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="219"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="416"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="577"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="668" mass="72651" checksum="8E33A46845EF5B4E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1W8</accession>
    <name>A0A1W1I1W8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47006">
        <property type="protein sequence ID" value="SLM47006"/>
        <property type="gene ID" value="NSJP_0834"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0834"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00266">
        <property type="entry name" value="TIGR00266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="227" mass="24482" checksum="F8E065B811DCC484" modified="2017-06-07" version="1">MKSEILYPGAFPMVRVELSAGETIKAESGAMVASSPTIDVESKMEGGFLGALSRKFLTGEKFFFQTLRATRGAGEVLLAPTVPGDIVVIELDGLNEYIVQKDGFLAGAETVKIDSQMQSLSRGLLGGEGFFILKLSGKGTLVLNSFGAIHRIELKPDQEYIVDNSHLVAWSATTSYHVERAAAGWVASFTSGEGFVCRFQGPGVVYIQSRNPGGFGHWLRQFIPVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I204</accession>
    <name>A0A1W1I204_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1722 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0681"/>
    <dbReference type="EnsemblBacteria" id="SLM46853">
        <property type="protein sequence ID" value="SLM46853"/>
        <property type="gene ID" value="NSJP_0681"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0681"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007553">
        <property type="entry name" value="2-thiour_desulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013560">
        <property type="entry name" value="DUF1722"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017087">
        <property type="entry name" value="UCP037004"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04463">
        <property type="entry name" value="2-thiour_desulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08349">
        <property type="entry name" value="DUF1722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037004">
        <property type="entry name" value="UCP037004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1722" evidence="1">
        <location>
            <begin position="192"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="317" mass="36676" checksum="82D301F0AE718C45" modified="2017-06-07" version="1">MTVNRLRLGISRCLLGEQVRYDGGHKRDRFLTDVLGQYVEWVPVCPEVEAGLSTPREAMRLIGDPKKPQLTTIKSGRNLTRPLALFAERKIEALEQSDLSGYVFKKDSPSCGIERVRIFNQQGMPSRTGIGIFARAFIERFPLIPVEEEGRLCDAPLRENFIERVFCYRRFQDLLQNVVTRQTVVRFHTAHKYLLLSHSQQHYQALGRLVGQAERHRPKDLALKYGELFMKALAVKATMRKHVNVLQHILGHLKDRLGDRDKAELLGVIGDYHRRLTPLIVPLTLVKHYVQKFDVAYIRDQIYLNPHPKELMLRNHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I297</accession>
    <name>A0A1W1I297_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47112">
        <property type="protein sequence ID" value="SLM47112"/>
        <property type="gene ID" value="NSJP_0940"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0940"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="115" mass="13012" checksum="FF81AD9F6A206318" modified="2017-06-07" version="1">MAFILEYIAPRGTDMSRDHTTRSPGGFQVRHRSLGLYQGSAIELAFWYPSSGMPEYGLYRFATETQAQSLIDFLVSAACAEPLSREDLQIEPFDLAEHERLVAEYPLPSAWEQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2B0</accession>
    <name>A0A1W1I2B0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46999">
        <property type="protein sequence ID" value="SLM46999"/>
        <property type="gene ID" value="NSJP_0827"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0827"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012574121" description="OMP_b-brl domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl" evidence="2">
        <location>
            <begin position="10"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="213" mass="22790" checksum="36383F4F8C385B77" modified="2017-06-07" version="1">MARSIWAFGLLALLSLPFTVRAETETHTDVYISLYALGSWPYDRDAFVLTGPAPGTSVGSGAGAGLKVAVFPVMGRGFFGIELESMGNSSNLSVPLTTGPGAGSVGRTNLWVFNSMANLILRYPGLPVIPYIGIGGGLSQGVLSGANIPGRSDQDFESSATFGYQFFGGLQTNVTKRIFLFGEYKYLSANYHWQSLSLEYRSQYLGAGIGLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2C8</accession>
    <name>A0A1W1I2C8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0998"/>
    <dbReference type="EnsemblBacteria" id="SLM47170">
        <property type="protein sequence ID" value="SLM47170"/>
        <property type="gene ID" value="NSJP_0998"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0998"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="133" mass="14865" checksum="B0DDF0BD8C165DC5" modified="2017-06-07" version="1">MIVADTNLLIYLYVQGQRTEESEAVLRRDAIWAAPLLWRSEFRNVLIGLVRNDVLALNEAISMVDEVERWLDGHEYSVISRNVLTLAEQSGCSAYDCEFVALAQDLRVPLVTADRHVLKAFPAVAISPSSFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2E2</accession>
    <name>A0A1W1I2E2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative NADH-quinone oxidoreductase, subunit L</fullName>
            <ecNumber evidence="9">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_0993</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0993"/>
    <dbReference type="EnsemblBacteria" id="SLM47165">
        <property type="protein sequence ID" value="SLM47165"/>
        <property type="gene ID" value="NSJP_0993"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0993"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="394"/>
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    </evidence>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
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                <person name="Spackman E."/>
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                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
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    <dbReference type="STRING" id="1325564.NSJP_0992"/>
    <dbReference type="EnsemblBacteria" id="SLM47164">
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
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                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
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            <end position="264"/>
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    </feature>
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    </evidence>
    <sequence length="292" mass="33069" checksum="A1ADA73AE52FEDC0" modified="2017-06-07" version="1">MADRKKRLESNVDGQFFVDATCINCDACRQLAPETFQEIGDYSAVMRQPVGETQTRRAYQALLACPVGSIGAERPDSTHMDHAKASFPLHLEGGVYYCGFNSEKSFGANSFFVHHPEGNWLIDSPRYIKHLVEAFEQKGGIRFMFLTHEDDVADADRYAGRFGAECFIHRADAGAVPFARRIIDGTAAQRLAPDFQVVPVPGHTPGSQALLYKERFLFTGDHLWWEPHPGRLNSPETLVWNREQLDRSIGILLDHRFEWVLAGHGDRVRLSVDELHRQLRRLLRRRQGVAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2L1</accession>
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                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="220" mass="24291" checksum="194DE3DEE46B678A" modified="2017-06-07" version="1">MAIGDSRVLKPEERERIGEAVRTAERRTRAEIVPMIVSRSGVYRDATHRAGLILALFTLTALLMSEAAWLPWSWDGENAAWLVLCTVAAYAAGAWSGTFAPIVRLITSRERMRQKVRLRAERAFAQHGIFQTRERTGILLMLSVLEREVYVLADKELIRLVSSGQWDEVVRSVIEGVRAGDMAVALCAGVSRCGEILAVACPATSGDNPNEIPDRVIDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2M7</accession>
    <name>A0A1W1I2M7_9BACT</name>
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        <submittedName>
            <fullName evidence="12">Putative Dihydrolipoyl dehydrogenase, E3 component of pyruvate and 2-oxoglutarate dehydrogenase complexes</fullName>
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        </submittedName>
    </protein>
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        <name evidence="12" type="ORF">NSJP_0957</name>
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    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="12"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0957"/>
    <dbReference type="EnsemblBacteria" id="SLM47129">
        <property type="protein sequence ID" value="SLM47129"/>
        <property type="gene ID" value="NSJP_0957"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0957"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0274">FAD</keyword>
    <keyword evidence="2 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="11">
        <location>
            <begin position="5"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="10">
        <location>
            <begin position="343"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="138"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="175"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="8">
        <location>
            <begin position="42"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM47129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="461" mass="49445" checksum="55174E69B6540FC0" modified="2017-06-07" version="1">MANSHDIVIIGGGSAGYAAARTAADRGAQVAIVDQGPLGGLCILRGCMPTKTILRTAEIAALMRRVKEFGLSPVDVTAHLEQIVDRKDRLVREFADYRIEQLRDPRYKLYQGAASFLSPNRVRIGSQEVEAKAFVIATGSVPNDISVPGLHETGYLTSDTLLDLRDRPASMVVLGGGPVALEFGQFFARIGTAVTIIQRSPHLLSHLDPDVGSALEQALREEGIVLYTGTALQRVERSGSNKRVTFHHEGREVHADGALILQALGRRPRIDGLALDKAGVAVINGRVAVDDTMRTSQPHIFAAGDVTNLYDIVHIAVQQGELAGFNALQSEGALRSFDSRLVTDVTFTEPQVATVGLSEMACRAGGIPHLAASYPFADHGKAMCRGDRHGFVKLVASPAGGKLLGAQIVGPEAGELIHELIAVMYYHGTVADLLRMPHYHPTLAEIITYPAETLAERIGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2T2</accession>
    <name>A0A1W1I2T2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1109"/>
    <dbReference type="EnsemblBacteria" id="SLM47281">
        <property type="protein sequence ID" value="SLM47281"/>
        <property type="gene ID" value="NSJP_1109"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1109"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012867943" description="FGE-sulfatase domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="3">
        <location>
            <begin position="51"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="312" mass="34906" checksum="D6D5A44D99B3DA13" modified="2017-06-07" version="1">MGITPVQLIAAWLFCLAMSSHAMADHESSKEPPLWTPLDGPERLASMDTPEGMVEVPAGWFVMGSDPKLDRAAGPQEQPQHNVYVDGFEIDKYEVSNVDYLRYVLARGADWPQFWRESPFPEKAALHPVINVSWHDADAYCRWAGKRLPTEAEWEKAARGEDGRVFPWGNEPAGWLKSNIAHPGSKRGFKYPPLANVNRYDRGVSPYGVHQLAGNVSEWVADWFDPDYYRSDENRNPTGPQWGTDKVFRGGSWNEDPEVARSAGRNAGAPDRRSYLTGFRCAKGMTPESGITHDVQSEIGAISPPVRVTQHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3K6</accession>
    <name>A0A1W1I3K6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Sensor histidine kinase</fullName>
            <ecNumber evidence="5">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_1297</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1297"/>
    <dbReference type="EnsemblBacteria" id="SLM47469">
        <property type="protein sequence ID" value="SLM47469"/>
        <property type="gene ID" value="NSJP_1297"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1297"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007891">
        <property type="entry name" value="CHASE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05227">
        <property type="entry name" value="CHASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="279"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="496" mass="55269" checksum="04582E5488CD3D2B" modified="2017-06-07" version="1">MESATQDRPTSIPAVSPDPSDALSASSKVRTPHRRRLPAWATRWSLEQRVLAGFGLVFAGIVVISAISYRNTSIVVRNSHLDTASHELIQLLASIGHTLDAAENGHRRFLVTGDDSYLKAHRSVLEQAPEYFRYLELLTADTPEQAPRVARLEELINRQIQAEVQAIEERERRGAEGVRHLALSGAAKHELSEIHAVMAELESDEQRLTQIRVVQSTASTRNTIALLVLGALLQLVLLGSVYYLIHYDVTARRRIAGELKRRGELLQAANKELEAFSYSVSHDLRAPLRHIDGYASLLAKTAGSTLTDKAQRYLQTISDSAKQMGQLIDDLLVFSRMGRQEMLHATVDLNQLVKTVIHDLRLDLQAKPISWTIDPLPEVSADPAMLRQVYMNLISNAVKFTATRSEPKIAIGVRDGAPGEIELFVRDNGVGFDMQYVNKLFGVFQRLHRNDEFEGTGIGLANVRRIVHRHGGRTWAEGALDQGATFYFSLPIKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3S1</accession>
    <name>A0A1W1I3S1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Octanoyltransferase</fullName>
            <ecNumber evidence="6 7">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">lipB</name>
        <name evidence="12" type="ORF">NSJP_1495</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6 7">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6 7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1495"/>
    <dbReference type="EnsemblBacteria" id="SLM47667">
        <property type="protein sequence ID" value="SLM47667"/>
        <property type="gene ID" value="NSJP_1495"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1495"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="11">
        <location>
            <begin position="42"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="87"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="171"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6 8">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="6 10">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM47667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="247" mass="27225" checksum="3282722100605A43" modified="2017-06-07" version="1">MNEPSTRREATRPGRLLIVAEPRDYADAWLLQQQLHAERVADRRSDTLLLLQHHAVYTLGRRTLPAHLPQGESALRATGAQVAVTNRGGSVTYHGPGQLVGYPVIRLSHSASGPKQYVWLLEETLCRTLAHWGIEAHRISKTPGLFVNVEGRTAKVASIGVRVEHGVTLHGFALNVDLDMTPFSRIIPCGLNSYRPTSMAALCRSSVPIHQVARQVAEQFALTFKLTWDLEALSGGTEFAEEHAHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I403</accession>
    <name>A0A1W1I403_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Peptidase S16, lon-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1560"/>
    <dbReference type="EnsemblBacteria" id="SLM47732">
        <property type="protein sequence ID" value="SLM47732"/>
        <property type="gene ID" value="NSJP_1560"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1560"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="229" mass="25925" checksum="5A8239C1A5C6775A" modified="2017-06-07" version="1">MQTDQERDPPGSPGRDRGPSFPIPSRIPIFALPNVVLFPKTYLPLHIFEPRYRQMVDDAVVAGQCIGMALLKEGWEPGYHGNPPIYSMGCVGRLVSVQPLGDGRSNILLQGLERFEVAEESYDKAYRQANIQVKTRPSESVLEEGLRKHLVSVLEDYLETREDAVAWQGWFRDDISDEILVHTLSSYLGCTALEKQFLLEAESLHQQARRLCDLIHFLMHGRHGVKGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I408</accession>
    <name>A0A1W1I408_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47748">
        <property type="protein sequence ID" value="SLM47748"/>
        <property type="gene ID" value="NSJP_1576"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1576"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="184" mass="20295" checksum="19CFEC3276025D08" modified="2017-06-07" version="1">MLVSLPVPEKTVKTGVSSRGARGWLCLSLAILFLTSGPVLAKSKIPRTPRPEPDLKILEFKINPTPYNASAGQLEFSAVVQLPKDLDGATLLEISSLLTSPSKTSIRFISTRKPLDDHEIPTATHTEFPRLPIVLTWDGMDHQKMPASAGLYHYEMRAKLLANGEKGPRTLMVSWPKRGTIEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I439</accession>
    <name>A0A1W1I439_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein DevR (DosR)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">devR</name>
        <name evidence="5" type="ORF">NSJP_1606</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1606"/>
    <dbReference type="EnsemblBacteria" id="SLM47778">
        <property type="protein sequence ID" value="SLM47778"/>
        <property type="gene ID" value="NSJP_1606"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1606"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="226" mass="24317" checksum="8CEC75BA07560F64" modified="2017-06-07" version="1">MAARTAPIRLLIVDDHEVVRIGLGAVLDLTPGLKVVGQASRKDEAKQLSLKLKPDLVLLDIRLPDGSGVEAARDILAACPNTRVLFLTSFADDHTVLEAILSGGQGYVLKDIASDSLVKAIKTVASGQPLMDPRLTKYTLHLIKHGPAQSGASKRPLLSPQEQRLLPLVAEGLTNKEIAVQLNLSEKTVKNYLANIYSKLQIGRRSQVAAFYAGSFKNLSAPLPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I452</accession>
    <name>A0A1W1I452_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CrtC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1559"/>
    <dbReference type="EnsemblBacteria" id="SLM47731">
        <property type="protein sequence ID" value="SLM47731"/>
        <property type="gene ID" value="NSJP_1559"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1559"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.370.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023374">
        <property type="entry name" value="AttH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010791">
        <property type="entry name" value="AttH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07143">
        <property type="entry name" value="CrtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012190347" description="CrtC domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="CrtC" evidence="2">
        <location>
            <begin position="57"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="377" mass="42629" checksum="4B8078D305D97000" modified="2017-06-07" version="1">MQMETSNRRCWWWALPALPLLATLTFAAKVTDEFRPATKGYVYQFPRDHGSHDEFRTEWWYYTGHLATATGRRFGYQLTFFRRGVPKEQITTFPSQWSISHLYLAHFAVTDLDGRQFRYAEKLSRAGLGKAGADSDRLHVWIDRWSAEAHPDPVRHRLQAADQDLALALDLTPDKPPVVHGTGGISRKGAAQAQASHYYSFTSMAAAGQLRIGHESFDVTGTGWMDHEFGSADLGEDVVGWDWFSLQLSDRTELMLYRLRRADGSADPVSSGTFIDKDGTPQHLAFKDLKLEPLSRWTSPASKAVYPQRWRLTVASKQLSLELAPLMAEQELTTTRSTQVTYWEGAIDVTGTVQEKPITGKGYMELTGYAERFTKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4K2</accession>
    <name>A0A1W1I4K2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">murG</name>
        <name evidence="13" type="ORF">NSJP_1733</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1733"/>
    <dbReference type="EnsemblBacteria" id="SLM47905">
        <property type="protein sequence ID" value="SLM47905"/>
        <property type="gene ID" value="NSJP_1733"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1733"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="187"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM47905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="375" mass="38712" checksum="70476481DD6D75C2" modified="2017-06-07" version="1">MMIVIAAGGTGGHLYPAVALAQEFLRRDPAVRVLFVGTARGLESKVLAHEGFELALISAKPVMGTGPVGILKGLAAMPLSFWQCLKILRSRRASLVIGVGGYTSPMMVAAAAAAGVARVILEPNANPGMANKAVGPFAQRIFVAFESAAQRFDRAKVRVVGTPIRRAFIQAALAGSGTSRTPGEFRLLIFGGSQGAKAINSAVIEGLRTVRDAQARLAITHQTGEADHARVTEAYRQAGISASVVPFIYDMPAAITGADLVVARAGAMTVAELTTCGKPAVLIPLPTAIYDHQTKNAQVMEAAGAAVLLPQSELTGKTLAQLIGSLAGDSGRLAAMAAASLSLRRTDAAEAIVRECYALVGGGHDKRQSLGAGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4L3</accession>
    <name>A0A1W1I4L3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47819">
        <property type="protein sequence ID" value="SLM47819"/>
        <property type="gene ID" value="NSJP_1647"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1647"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="104" mass="11372" checksum="E19F9DE11926001C" modified="2017-06-07" version="1">MMMGILSKRSWLVWSLLVWLILTSGIMGASSVVHLHHHGNNHSGTHATGPCTWLCAAGQAVESGLVHLSFQSRSTVPVDWLIHDALTTPPSLQVWFRGPPHVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4P6</accession>
    <name>A0A1W1I4P6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase GroES domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1816</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1816"/>
    <dbReference type="EnsemblBacteria" id="SLM47988">
        <property type="protein sequence ID" value="SLM47988"/>
        <property type="gene ID" value="NSJP_1816"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1816"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="13"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="339" mass="35433" checksum="682C2E4563B6A951" modified="2017-06-07" version="1">MAQMTAIQINSPGGRFEVVSRNVPEPTPNTVRIKIQACGVCHSDVFVKEGHWPGLQYPRVTGHEIAGVIDAVGADVTEWTKGQRVGVGWHGGHCGRCTPCRRGDFMGCQNFIVTGFMSDGGYAQFMIARSEAVAAIPDGLSPAEAAPLLCAGVTTFNSLRHSGAIAGDIVAVQGLGGLGHLGIQFASKMGFRTVAVGRGKDKEALALKLGASHYLDGGTVNAAGELAKMGGASVILATAPNSRAMSELIDGLAVGGKLLVVGAAADPITVTPIQLIGARRSVQGWPSGTARDSEDTLKFSALTGIRPMIETFPFEQASAAYDRMISGQARFRVVLTMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4X5</accession>
    <name>A0A1W1I4X5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Phosphate acyltransferase</fullName>
            <ecNumber evidence="3 4">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">plsX</name>
        <name evidence="5" type="ORF">NSJP_1767</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PlsX family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="3 4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1767"/>
    <dbReference type="EnsemblBacteria" id="SLM47939">
        <property type="protein sequence ID" value="SLM47939"/>
        <property type="gene ID" value="NSJP_1767"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1767"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00019">
        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002465">
        <property type="entry name" value="Phsphlp_syn_PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00182">
        <property type="entry name" value="plsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="364" mass="38694" checksum="BBF16A584C6A5613" modified="2017-06-07" version="1">MTNASSVAADQPNLQARVTTPSRMKIALDAMGGDHGPAPCIEGALSAAQDFDVDVVLVGDEKVLADECRRLGSTDPRLSIKHAPQVVEMHESPATVARKKRDSSIWIATELVKNGEADAVVSPGNTGASMVASFFVLGLTKGVERPAIATSLPTLTGEAILLDVGANVDCTAQHLTQFAIMGNEYGKHLFRKPNPRVGLLSIGEEDSKGNEVTKEAFKILKGSALNFVGNVEGRDVYSGNADVVVCDGFIGNVALKISEGVAETIKKLLFKEISGSLLGRLAYPLIASPLRNLKRRIDYAEFGGAPLLGVNGITMICHGRSSAKAIKNAIRRAKGLAESRVDELIQRDIEESLAQSRLPEEPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I504</accession>
    <name>A0A1W1I504_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5615 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48080">
        <property type="protein sequence ID" value="SLM48080"/>
        <property type="gene ID" value="NSJP_1908"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1908"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041049">
        <property type="entry name" value="DUF5615"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18480">
        <property type="entry name" value="DUF5615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5615" evidence="1">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="110" mass="12209" checksum="58B59482CAEEDDAB" modified="2017-06-07" version="1">MPGKIRFYLDEHVPRAVVQGLRERGVDIKTVGEAGLLSAPDTAHMQQARAERRVIFTQDSDFLRLHAAGHTHCGIVYAPQGTSIGETIHGLMLLHQILKADEMEGHVEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I546</accession>
    <name>A0A1W1I546_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Adenosylhomocysteine nucleosidase</fullName>
            <ecNumber evidence="2">3.2.2.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.9" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1837"/>
    <dbReference type="EnsemblBacteria" id="SLM48009">
        <property type="protein sequence ID" value="SLM48009"/>
        <property type="gene ID" value="NSJP_1837"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1837"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008782">
        <property type="term" value="F:adenosylhomocysteine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="259" mass="27562" checksum="5E425384697EF1FE" modified="2017-06-07" version="1">MKPVAIFAATRWELRALHRAFPTARAATLAGLRCFADDRAGQSYRLIQTGIGPEAAARVAKAVMDAQAMESIISAGFACALVPAQVGDVMIGSQSVFARSTGCWEIQGDVVACDDGLNEEMRTLARETGLPVRAGRFVSVATVVGRAEEKQRLARTADAVALDMESQALGAAARQRGVPFAIVRTVSDLLDEDLPLDFNQFLRPLGWPKGLGQVLAHPGSLAGLNRLRKQSSLAAERLTGLFTRYAAARLEGRGIGVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I568</accession>
    <name>A0A1W1I568_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48142">
        <property type="protein sequence ID" value="SLM48142"/>
        <property type="gene ID" value="NSJP_1970"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1970"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="44"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="182" mass="19539" checksum="43CDC4BA140299A1" modified="2017-06-07" version="1">MQVRQAEPQLATPSTQSEQFIQEASLYVQQMLSGGIPRHEILTCLAKAGEFLAGPGCSVSILVLDEDGLLRNGASPNLPADYLRAIDRLKPDPMVGTCSVAAATGSVVITQDFCADDRWAELRHLPISLGFVGAWSMPIKSRTGTVLGTFGTYFRSRRTPTRHEQEGVEQLAAAAALVLAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I587</accession>
    <name>A0A1W1I587_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidinol dehydrogenase</fullName>
            <shortName evidence="1">HDH</shortName>
            <ecNumber evidence="1">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 7" type="primary">hisD</name>
        <name evidence="7" type="ORF">NSJP_2005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1 5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 6">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2005"/>
    <dbReference type="EnsemblBacteria" id="SLM48177">
        <property type="protein sequence ID" value="SLM48177"/>
        <property type="gene ID" value="NSJP_2005"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2005"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0520">NAD</keyword>
    <keyword evidence="1 2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1 3">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1 3">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 4">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 4">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 5">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 5">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 5">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 5">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="427" mass="46110" checksum="F0A49044FA19F377" modified="2017-06-07" version="1">MKIVASTDRAFVSALKKVVSRARMQGAAVERTVRTLLQAVERGGDAAVLRYTKQFDKVALKASELKVTSEEIKDAYHRIRKDEGDALRFAAQRIAAFHERQRTKTWMYQDGEATLGQVVTPIDAVGLYVPGGKAVYPSTVLMSAIPAKVAGVSRIVMCTPPQKDGINPYLLVAADIAGVTDIFRVGGVQAVGALAFGTKSIPKVDKIVGPGNIYVATAKRLLYGTVGVDMVAGPSELLVVADGDAKPAHVAADLLCEAEHDEDAQVWLVTTSASLAKNVGRLLEQQLRGLQREKIAAKSVARHSVAFVVTTMDEAIEVANQIAPEHLTLSVDQPFDYLEKIRHAGALFLGRYTPPSVADYIAGPNHVLPTGGTAKFFSALSVLDYLKVSNIVHYTKEELSKVKDHLIRFAHIEGFDAHAKSAQSRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5B0</accession>
    <name>A0A1W1I5B0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Peptidase M48, Ste24p</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_2008</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48180">
        <property type="protein sequence ID" value="SLM48180"/>
        <property type="gene ID" value="NSJP_2008"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2008"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="78"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="289" mass="30465" checksum="8656FE2D00583B79" modified="2017-06-07" version="1">MAVAPRRGGIWCLVVYCVVVTVGLLGCEKNPYTGRSQLLMTSVGEEMEMGAQAYSQVKSDPKMRPSQNPREIEPVKRVAARIVEAARRSKYGEMAKQFQWEVTVIKDDKTANAFALPGGKLAVYTGIFPVAKTEAGLAAVMGHEVVHALARHGAERMSQEQLANAAVQAAGAAVGASGGGGLLSQGTIAALGAGAQVGVLLPFSRQHESEADYIGILLAADAGYDPRESIALWERMERMSGGGGPAEFLSTHPSHGTRIEDLKKAMPEALNIYKTRQPVPAADLPGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5B7</accession>
    <name>A0A1W1I5B7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Quinol-cytochrome c reductase, iron-sulfur subunit, modulated with PRC-barrel (Modular protein)</fullName>
            <ecNumber evidence="9">1.10.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_1851</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.10.2.2" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1851"/>
    <dbReference type="EnsemblBacteria" id="SLM48023">
        <property type="protein sequence ID" value="SLM48023"/>
        <property type="gene ID" value="NSJP_1851"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1851"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030077">
        <property type="term" value="C:plasma membrane light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045156">
        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014747">
        <property type="entry name" value="Bac_photo_RC_H_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="8">
        <location>
            <begin position="196"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="310" mass="34743" checksum="C090109E46A87605" modified="2017-06-07" version="1">MQPKLKSKVHCSDREVGEVTSVIVDPLSRQISHIVVSMNGHGERQVGMGQVQSVTEGAVQLRTTSSEVVALPAFKRDEYVTSHEVEIPHLEDNIHVTPGEVLVPFPELEKSVKRRTFFMNFTHAIGFLIGLPIAFPILRYLMKPMYAPFDNDWLSIGNVGKIKQDDIGVQFKYKKKVKEAYMPESEIEKNVWILKGTPAVLEKVYQGKDMEFRDALGKTIWTNKKDIPYVAFSGKCPHLGCGYKWRQHKVLGQVFLCPCHLSIYDASGKVLDGPAPRPLDALPIRVSAGGAVEIIDMEFKAGTKSQIRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5B8</accession>
    <name>A0A1W1I5B8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">murA</name>
        <name evidence="9" type="ORF">NSJP_2003</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2003"/>
    <dbReference type="EnsemblBacteria" id="SLM48175">
        <property type="protein sequence ID" value="SLM48175"/>
        <property type="gene ID" value="NSJP_2003"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2003"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="419" mass="44514" checksum="CCDCB7A6EB6782B6" modified="2017-06-07" version="1">MDKIVINGGVSLKGRVRVSGAKNSALPILASTILGGGECMISNVPRVVDVVTMGKLLGILGAKVTQEASRVVIKADVINSTQAPYELVKTMRASILVLGPLLARWGQATVSLPGGCAIGSRPVNMHLAGLTKLGAEVWVEHGYIHARAKRLTGAAIYCDVPTVTGTENLMMAASLAQGTTVIENAAKEPEIVDLADFLTKRGARIIGAGTDMITIEGVRELRGSDHEVIPDRIEAGTYLVAGAITRGSISVDRCRPDHLEPVIAKLRETGADIRVEKESVHLNAGASGRPDGVDIRTMPFPGFPTDMQAQMAALMAVARGTSIITETVFESRFMHVEELRRMGADIRVEGNRLMITGCERLTGAPVMASDLRASAGLILAGLAAEGTTEVLRVYHLDRGYEDIEDKLRGLGAVIDRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5I0</accession>
    <name>A0A1W1I5I0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate 5-kinase</fullName>
            <ecNumber evidence="8">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyl kinase</fullName>
            <shortName evidence="8">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">proB</name>
        <name evidence="10" type="ORF">NSJP_2106</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2106"/>
    <dbReference type="EnsemblBacteria" id="SLM48278">
        <property type="protein sequence ID" value="SLM48278"/>
        <property type="gene ID" value="NSJP_2106"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2106"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="282"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="216"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM48278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="373" mass="40095" checksum="01D8E3AAE3E3662B" modified="2017-06-07" version="1">MRDEILTSAKRIVVKIGSSLVSSKDAGLRPDRIDRLADEISMLRTDGREVLLVSSGAIVSGIKKLGLKEYPKSLPVKQAAAAVGQSRLMWAYEKSFERLGVKVAQILLTHQDLADRRRFLNARHTLAALIGFGVVPVINENDTVAVDEIRVGDNDSLAADVAHLVDADLLVILSDIDGLFTQDPRKNPSATLIPLVSEITEEIEQRAGVSTTFEGTGGMATKVRAAKKVGEYGVATLILNGQQAGLLPTVLAGGDGGSLFLPKGRRMTSRKLWIAFTLRPQGQLLLDAGAVVALAERGKSLLASGIIDVKGTFEAGDPVSCLNQDGKEFAKGLVNFSSDVIARMKGLKTVDVQQRLGPQEYDEIIHRDNLVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5I8</accession>
    <name>A0A1W1I5I8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48149">
        <property type="protein sequence ID" value="SLM48149"/>
        <property type="gene ID" value="NSJP_1977"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1977"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="90" mass="10096" checksum="8F710331B8007DAF" modified="2017-06-07" version="1">MTKGADLRLDSLIEGSSGNRNLPWMHGEYRRLKRGVKASPVEKPLAESPDLCYALARPIHDRFYCNRRYAAATSLAASFRKPSGQAWRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5L6</accession>
    <name>A0A1W1I5L6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydbL</name>
        <name evidence="2" type="ORF">NSJP_2135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2135"/>
    <dbReference type="EnsemblBacteria" id="SLM48307">
        <property type="protein sequence ID" value="SLM48307"/>
        <property type="gene ID" value="NSJP_2135"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2135"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008309">
        <property type="entry name" value="UCP025560"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07027">
        <property type="entry name" value="DUF1318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025560">
        <property type="entry name" value="UCP025560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013229793" evidence="1">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="109" mass="11637" checksum="2469DECA9224BDAE" modified="2017-06-07" version="1">MRKIGIIVVVALCGLWPVSTVLATSLEEAKAKGLVGEKANGYLGVVTPSGQDVQVLVNDVNKKRRQAYDEIAKRNKTPLDAVEALAGEKAIQNTHPGNYVEGPGGWVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5L7</accession>
    <name>A0A1W1I5L7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48123">
        <property type="protein sequence ID" value="SLM48123"/>
        <property type="gene ID" value="NSJP_1951"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1951"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="97" mass="9809" checksum="E5984478A75EAD03" modified="2017-06-07" version="1">MKNWRRLFLGLTSTALLMVPFGLPVGAEQQKEGQSSSQSQGKSDEQSKGKSATGQPSAGGPQGEDKAGGGGPSGPQATPPGKAPQFEGANKGQNKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5N3</accession>
    <name>A0A1W1I5N3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3 7">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">leuA</name>
        <name evidence="9" type="ORF">NSJP_2017</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3 7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2017"/>
    <dbReference type="EnsemblBacteria" id="SLM48189">
        <property type="protein sequence ID" value="SLM48189"/>
        <property type="gene ID" value="NSJP_2017"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2017"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01025">
        <property type="entry name" value="LeuA_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005671">
        <property type="entry name" value="LeuA_bact_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00973">
        <property type="entry name" value="leuA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="515" mass="56309" checksum="17D20BD4062BF7E4" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5N6</accession>
    <name>A0A1W1I5N6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Catalase</fullName>
            <ecNumber evidence="11">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">katA</name>
        <name evidence="13" type="ORF">NSJP_2156</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="11"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2156"/>
    <dbReference type="EnsemblBacteria" id="SLM48328">
        <property type="protein sequence ID" value="SLM48328"/>
        <property type="gene ID" value="NSJP_2156"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2156"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08156">
        <property type="entry name" value="catalase_clade_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040333">
        <property type="entry name" value="Catalase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 11 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="12">
        <location>
            <begin position="8"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM48328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="485" mass="54784" checksum="D1DDB56B2112BD07" modified="2017-06-07" version="1">MSEEKKLTTNAGCPVAHNQHVMTAGPRGPQLLQDVWFLEKLAHFDREVIPERRMHAKGSGAYGTFTVTHDITKYTRASLFGKVGKKTELFARFTTVAGERGAADAERDIRGFAVKFYTDEGNWDLVGNNTPVFFLRDPLKFPDLNHAVKRDPRTNMRSAKNNWDFWTSLPEALHQVTIVMSERGIPASYRHMHGFGSHTFSLISADRRRYWVKFHFKCQQGIKNLTDAEAEAIVGKDRESHQRDLYESIEKGDFPKWTLKVQVMPEADASKVPYHPFDLTKVWPHKDYPLIDVGVMELNRNPENFFAEVEQSAFNPASIVPGIGFSPDKMLQGRLFSYGDAQRYRLGVNHHLIPVNAPRCPAHSYHRDGAMRVDGNFGGTPGYEPNSEGQWREQPDYAEPPLSLEGAADHWNHRDDADYYSQPGALFRLMTQEQRQTLFGNTARSVGGAPREIQIRHIKNCLKADRAYGKGVADALGISLADVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5S4</accession>
    <name>A0A1W1I5S4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative fused MFS-type Permease and bifunctional Acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase/Acyl-[acyl-carrier-protein] synthetase</fullName>
            <ecNumber evidence="8">2.3.1.40</ecNumber>
            <ecNumber evidence="8">6.2.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_2163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.40" evidence="8"/>
    <dbReference type="EC" id="6.2.1.20" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2163"/>
    <dbReference type="EnsemblBacteria" id="SLM48335">
        <property type="protein sequence ID" value="SLM48335"/>
        <property type="gene ID" value="NSJP_2163"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2163"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008779">
        <property type="term" value="F:acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008922">
        <property type="term" value="F:long-chain fatty acid [acyl-carrier-protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
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        <property type="entry name" value="ANL_N_sf"/>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
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    </dbReference>
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        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
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        </location>
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        </location>
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        <location>
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        </location>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="378"/>
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        <location>
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        <location>
            <begin position="8"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1137" mass="122145" checksum="3FD99BC25943DA29" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5V7</accession>
    <name>A0A1W1I5V7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
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            <taxon>Nitrospira</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="SLM48213"/>
        <property type="gene ID" value="NSJP_2041"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2041"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010709651" evidence="1">
        <location>
            <begin position="24"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="152" mass="17138" checksum="AD9DB09DF2C4FCF2" modified="2017-06-07" version="1">MQRAALVIIGLLMCSGCASMSGAKDQYFVCSYDIAWDAVLESVKDRPIQVQSKEKGLIETNWVEMEGAERAYGMFQREGFGNRERARMTVALKPLNDVVSVSVLETRQRWHLKGGITQEATKWWPIDPSEESETMVMDRIKTTLNQKGCATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I601</accession>
    <name>A0A1W1I601_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
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            <taxon>Nitrospira</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48420">
        <property type="protein sequence ID" value="SLM48420"/>
        <property type="gene ID" value="NSJP_2248"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2248"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="160" mass="17980" checksum="1CDBDAA8F9BE92B5" modified="2017-06-07" version="1">MNILQDLRVDEVSLVSEGANKGARIIIVKRNEESDSPMAPADIFTRDELFASLCAVLKTEYPKLNLPQAVATMAKEYPDELQAWRECHRTAPFDRSEVRLRNVGTSSHSAIEEFEQRAQSLVAQGEVENLVDAVCLIAHNDPDFYEVYVQEVRGGQTPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I633</accession>
    <name>A0A1W1I633_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gpx</name>
        <name evidence="8" type="ORF">NSJP_2263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="SLM48435">
        <property type="protein sequence ID" value="SLM48435"/>
        <property type="gene ID" value="NSJP_2263"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2263"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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        <property type="term" value="F:glutathione peroxidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
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        <property type="entry name" value="GPX_AS"/>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
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        <property type="entry name" value="Thioredoxin_domain"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012777286" description="Glutathione peroxidase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="33"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="196" mass="22029" checksum="F1242D368DEE153D" modified="2017-06-07" version="1">MLTRLIAISTLVMSSGFVFGLPDVPAAEEPLVASKTASLYDFTMDDIDGKPVNLKEYHGKVLLVVNTASMCGNTPQYTDLETLYEQYHEQGFEVLAFPANNFGQQEPGSNAEIKGFCLTKYSVTFPLFSKISVKGSDKHPLYQYLTEQSPFPGEVEWNFQKYLIDRSGNVVDRFHHRTKPLAPEVVKEVERVLAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6C2</accession>
    <name>A0A1W1I6C2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OstA-like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2368</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2368"/>
    <dbReference type="EnsemblBacteria" id="SLM48540">
        <property type="protein sequence ID" value="SLM48540"/>
        <property type="gene ID" value="NSJP_2368"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2368"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005653">
        <property type="entry name" value="OstA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03968">
        <property type="entry name" value="LptD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013048714" description="OstA-like_N domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="OstA-like_N" evidence="3">
        <location>
            <begin position="38"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="186" mass="19913" checksum="C6F23B77ED460D50" modified="2017-06-07" version="1">MLKCLLFLSVALAGVVVAAHPSLAAPVTAGADQTVSTTITSKKMTVKNQDSQAIFEGTVVLTRGTLVVYSDRMIVSFGSAQSNGTEDRKGRETASPRKGPDTVSNRAVNRIEAIGRVKIERDSGNATCEKAVYYREEDKIVLTGSPVAWEKGTRVSGKQITMFLAEDRSVVEGGSHVRIEPEGEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6F1</accession>
    <name>A0A1W1I6F1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">ureF</name>
        <name evidence="5" type="ORF">NSJP_2392</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2392"/>
    <dbReference type="EnsemblBacteria" id="SLM48564">
        <property type="protein sequence ID" value="SLM48564"/>
        <property type="gene ID" value="NSJP_2392"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2392"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="273" mass="29983" checksum="51AF91FE73C9F3F1" modified="2017-06-07" version="1">MTMLTRTDTGIRTIMPIKHAPGPDSPGHAQPTHSPSSTVPGRDLRLTITELMRVLQFGDSVVPVGAFSFSNGLESAIQLQFVRDLETLRQFVMTATRQSASSDAIALLAAHRAARAHDLRDALRADTALFNRKINEEMRTMSVRMGKKLAELSSHLNRTPLVTNWLGHIERKETPGTYPVCLGLLFAELNLPEHDAFAAHQYGTASMIVSASLRLMKIHHLDAQSILFEVNATAEAEYARVSGATLDDMATFSPSLDVMAAAHVKAHVRMFMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6F6</accession>
    <name>A0A1W1I6F6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Site-specific recombinases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pinR</name>
        <name evidence="3" type="ORF">NSJP_2251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2251"/>
    <dbReference type="EnsemblBacteria" id="SLM48423">
        <property type="protein sequence ID" value="SLM48423"/>
        <property type="gene ID" value="NSJP_2251"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2251"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="1">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="2">
        <location>
            <begin position="172"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="561" mass="64456" checksum="ECC9B3A869DFBA81" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6H3</accession>
    <name>A0A1W1I6H3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2456"/>
    <dbReference type="EnsemblBacteria" id="SLM48628">
        <property type="protein sequence ID" value="SLM48628"/>
        <property type="gene ID" value="NSJP_2456"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2456"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="344" mass="38827" checksum="04DBCF30F4EC9664" modified="2017-06-07" version="1">MIEAKPVQDYLFAFHGIELHYHASSVTLAEPVLAFLRHYRSESASEKTVLTVRFEEVRSTADIPYRISKTSKTLFSGTRPAMGDSLRSIWRCDVVQDRDRLVADFHDQGLLVIDGVLGTAEGYFINPEAMHADVRTSFFHFALSELLKRRGLFTVHATALEFQGRGVLIPGYSGQGKTTAFLSLLRSGFHYLSDDYPLIRDLGGHMELLAFPMKIDVTDHSVEFFPELRTAPTGLLQQGICKKFFHAEDLYENSIGTSCVPAIIMFPHVVDMPHSCLEPLAKSRALEALMPQGLLVYDQEVARREFHALSKLVQQTDCYRLHFGRDILDLPDLIKPLLELRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6V8</accession>
    <name>A0A1W1I6V8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c biogenesis protein CcdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ccdA</name>
        <name evidence="3" type="ORF">NSJP_2548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2548"/>
    <dbReference type="EnsemblBacteria" id="SLM48715">
        <property type="protein sequence ID" value="SLM48715"/>
        <property type="gene ID" value="NSJP_2548"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2548"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="13"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="251" mass="26955" checksum="828C1DD779EB4E23" modified="2017-06-07" version="1">MLDSLPQTSLLAAFLAGLLSFVSPCVLPLVPSYLMYITGLSLNQLTDAAERRLERMTIVVNALLFIAGFSLVFIAFGASASLIGQLLTDHQQFIRKAGGILIIVFGLYTMGLVKLRFLMTEKRIHLRSRPAGYAGSLLIGATFAAGWTPCVGPVLGAMLMYASTTDTLADGVTLLAFYSIGLGLPLFTAAMGMERFLSSFKRVHRYIGVMSSISGVFLVVFGLAIYSDSLTLMTSFLERYGIGSYLGTDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6W0</accession>
    <name>A0A1W1I6W0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RHS repeat-associated core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_2585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2585"/>
    <dbReference type="EnsemblBacteria" id="SLM48752">
        <property type="protein sequence ID" value="SLM48752"/>
        <property type="gene ID" value="NSJP_2585"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2585"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003284">
        <property type="entry name" value="Sal_SpvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022044">
        <property type="entry name" value="TcdB_toxin_mid/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022045">
        <property type="entry name" value="TcdB_toxin_mid/N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03534">
        <property type="entry name" value="SpvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12255">
        <property type="entry name" value="TcdB_toxin_midC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12256">
        <property type="entry name" value="TcdB_toxin_midN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01341">
        <property type="entry name" value="SALSPVBPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="TcdB_toxin_midN" evidence="6">
        <location>
            <begin position="707"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="TcdB_toxin_midC" evidence="5">
        <location>
            <begin position="927"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="2104" mass="236426" checksum="A779AF60C364D2DA" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Z4</accession>
    <name>A0A1W1I6Z4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative Cytochrome b/b6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NSJP_2411</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2411"/>
    <dbReference type="EnsemblBacteria" id="SLM48583">
        <property type="protein sequence ID" value="SLM48583"/>
        <property type="gene ID" value="NSJP_2411"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2411"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005798">
        <property type="entry name" value="Cyt_b/b6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00033">
        <property type="entry name" value="Cytochrome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51003">
        <property type="entry name" value="CYTB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="11">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_CTER" evidence="12">
        <location>
            <begin position="215"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM48583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="342" mass="37659" checksum="C2936408B2A89373" modified="2017-06-07" version="1">MAVDTVKTEKNDVGTDKSWVDYIQKDLPEHLEWWPYTLGAIPLTLFGILVTTGLLLTFYYVPASDQAYESVDQITHEIYLGWFVRGLHKISVDLMILFLLFHVIRVFMTRAYQGGGELKWVSGSIVLFVTLAMGFTGYSLVYDNVSYWGMTVVTNMVGTLPVAGRPLLHLLRGGEEVSGVTLLRLYDLHTKLLPVLLGGLALGHVVTVRLLGFTTVAGSRAFHPFYPEHTMKMGAVAVGFLLFMVDLVMIFPPTLGPPANFQEVASDVSPPWYFSAPFMWISLLPGPLALWSLMAGAGLFVAYPFVDRVLAARGWPMTFINGAVAAAAVGAMVVLMYLDLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I718</accession>
    <name>A0A1W1I718_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48721">
        <property type="protein sequence ID" value="SLM48721"/>
        <property type="gene ID" value="NSJP_2554"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2554"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="220" mass="24098" checksum="D6DEA383CCB94B84" modified="2017-06-07" version="1">MLLLLRRIVSLTLGLVPLFLIWAGLRSLLFPNPPPDPTLYSVRGQNLQPINPLLFFGGGVVGLFGCYRMCRADGGWKWVLVLMAVFVYALILPVMQNGIHGPPGQGASFGTSRQLRYLAHTATRLAREQGKFTCDAATELTQPSLFVQEGQTLSYVIQCVSDATGPVAGTPPERPGTLVFAVSPDRKRAWFTATVLARTPDSHATWIKDNGGRFFIEVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7D1</accession>
    <name>A0A1W1I7D1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48917">
        <property type="protein sequence ID" value="SLM48917"/>
        <property type="gene ID" value="NSJP_2750"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2750"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="14"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="116" mass="13180" checksum="4324357BDB91E59F" modified="2017-06-07" version="1">MQLPLQKGMCRTLRIEPRFPVAFTGTVSYQDYPHLITKSLDLSRAGCRLESPLQLSAGMKVNLLLCFLEGSTLILIEQAVVRWCHARQIGVEFQAVSTTYQTKLNRTLQRLTRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7E7</accession>
    <name>A0A1W1I7E7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cdsA</name>
        <name evidence="9" type="ORF">NSJP_2622</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2622"/>
    <dbReference type="EnsemblBacteria" id="SLM48789">
        <property type="protein sequence ID" value="SLM48789"/>
        <property type="gene ID" value="NSJP_2622"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2622"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="289" mass="31464" checksum="77BE21F708EB8D54" modified="2017-06-07" version="1">MVECRITSPDQPIPTVARRFDARRVYTVLVLAPLLYGAIRYFPPFAFTGLVLAVGSIALMEFYRLGLMPPGERPYVGVGLLGFAALLLTPHHGEFLIPTLLAAVLGVLSLPLIMRLPLDQVLRNSAATLLGILYLGVTLSFAVRLRLLEHGEWLVFFLLLVTWAGDTGAYYAGTIWGRHRLAPRISPKKSVEGLMGGVLAAMIAAYLARWWFLPTLSMIDCAVLAALLTLAGLWGDLAESAMKRSVGAKDSGGVLPGHGGMLDRLDSLLFTAPTFFYYVTLMTRSETLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7S0</accession>
    <name>A0A1W1I7S0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49057">
        <property type="protein sequence ID" value="SLM49057"/>
        <property type="gene ID" value="NSJP_2890"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2890"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="427" mass="47689" checksum="923CD2B3788595A7" modified="2017-06-07" version="1">MTRMLGFFCSACAGRPANTAIPATMIAQAFSLERMSYLLVETTNQSPSRRVSMYVECFTGPTPLCRHRDRFDECVDHVIRRDPVGIRVVRQHHPVPQYTVRHGADVVGRHVIAALEPGIRPGGAIEADAAPRAGSHLNPFTELLAQFIRMSCGVDEVHDVSGDGVGHMDAGDLAPGGQNRVGGNPSVFLFLTVRTWLDPRGFFAPHQLQDAHFALRVGIIDQHLHQEPVELRLRQGIGAFLLDGILRRQHHEQIRHRMGRTSDGDLPFLHRFEQRGLHLRRRAVDLVGQNDVAENRPLLKLEQILAAFLIQDFGPGNVGRQKIRRELDAAHRGVQIPCQAFNGSCLRKTGKAFEQEMSVGQQADEDLADDAALADDRRLHFALKIGDGLAWRHVLRILWTAVRVAAQLKLKANVELECRKTWNSRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7S8</accession>
    <name>A0A1W1I7S8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_2893</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2893"/>
    <dbReference type="EnsemblBacteria" id="SLM49060">
        <property type="protein sequence ID" value="SLM49060"/>
        <property type="gene ID" value="NSJP_2893"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2893"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="470"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="849" mass="89840" checksum="C90BCBB9FBBA9620" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7W6</accession>
    <name>A0A1W1I7W6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">zwf</name>
        <name evidence="9" type="ORF">NSJP_2782</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2782"/>
    <dbReference type="EnsemblBacteria" id="SLM48949">
        <property type="protein sequence ID" value="SLM48949"/>
        <property type="gene ID" value="NSJP_2782"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2782"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="7">
        <location>
            <begin position="13"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="8">
        <location>
            <begin position="196"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="489" mass="55602" checksum="215E1A6717B81344" modified="2017-06-07" version="1">MMAEKSVEPHIFVILGATGDLTRRKLMPALFHLRTLGELHKQNTLIVGAATPEMSEEAFRLWVYEGLRNSGAPDSPDLRRWCDDHLHYLTVHGGALEDYEALAVLLTRLEGTGRKPANRIFYLALPPTIVPFTVERLDQTGLLKSDGWVRVVFEKPFGHDYASARALNALLHRHLDESQIYRIDHYLGKETVQNLLAFRFANPIFETLWNRDMVESVQITVAEDLGVEHRGSYYQEAGALRDMVQNHLTQLMTVVAMEVPVSFDAAAIQTEKLKVLQSIDPIDPRDVAFGQYTAWSVADRVIPGYRQEQGVSPDSMTETFVAMKMDVHNWRWRGVPFYLRTGKRLPRKLTQVAVTFRPAPFQVFRSLEPESLDPNRLLITLQPNEGFALCFSVKTPARPLSFTSQSLQFDYGRAFGGELPDAYETLLRDVMIGDQTLFVSADFTETAWRLYDPLLAGRHDVHFYTAGSWGPKEADAVVERNGHRWQLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7X9</accession>
    <name>A0A1W1I7X9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2746"/>
    <dbReference type="EnsemblBacteria" id="SLM48913">
        <property type="protein sequence ID" value="SLM48913"/>
        <property type="gene ID" value="NSJP_2746"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2746"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="226"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="613" mass="68801" checksum="B8B6DBAD7BFD2B11" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Y5</accession>
    <name>A0A1W1I7Y5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48969">
        <property type="protein sequence ID" value="SLM48969"/>
        <property type="gene ID" value="NSJP_2802"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2802"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013071474" evidence="2">
        <location>
            <begin position="28"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="496" mass="54767" checksum="6A7CD62AC588D2F7" modified="2017-06-07" version="1">MNRRHYSFWAKCLQLVLMVLALDHAHAQPTGGDVFSSDSGNGKTWWDVKRRDYPDCAGLVDQHESMTQELYRLDAEAKRSVEPQRKQIVQQINDLSHQRTQVQRQIFACIRASGGKESTLSPSAPDREGVATRDSPGGDTVRAEEILTPQGRKLLFQLGAEMNEIAKEQGGHSDAGSEFLGGLADWAGETIQFLAQKPGAPVEQTAKGIMDYLTNDNAANHRALRSAAEEAVRDFKKNPARFLGKNLPDLLPTPGSATNKARALQRISQVEKGAGRIKRMAASEKKLEGFYKKVGPPAEGYGTKVQEHACFAINSCVDEALAEAQLFKTGGPIGDGTPWKITGVRGLETPKFPDAPSGRPPLTPDSPNWPKGMPYDPNQPLLDLRHTPDQLYAKLKPYGDNFAPKRPGTYNPEQLDMIWNGRPIPMEGPEHIAKLLEREGIGSQGLVIAEYKRPQGNVSGHVINFQNPDGKVAVIDRTHLRKDVSEVENWLFFPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I801</accession>
    <name>A0A1W1I801_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YjgF_endoribonc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2963"/>
    <dbReference type="EnsemblBacteria" id="SLM49130">
        <property type="protein sequence ID" value="SLM49130"/>
        <property type="gene ID" value="NSJP_2963"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2963"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjgF_endoribonc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="152" mass="16103" checksum="6429805E1B435DCA" modified="2017-06-07" version="1">MSFEVRMKELGLELPAAPKPVATYVPAVRTGDLLFVSGVLPMQQGQLAWSGKLGRELRVEQGVEASRTALLNALAIVKQEIGTLDRIVRIVKVVGHVASAEGFTDQPQVLNGASDLLVSIFGDTGRHARVAVGAAELPRGAAVEIELILQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I814</accession>
    <name>A0A1W1I814_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48999">
        <property type="protein sequence ID" value="SLM48999"/>
        <property type="gene ID" value="NSJP_2832"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2832"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="220" mass="25750" checksum="EB43B3ACE15D8D89" modified="2017-06-07" version="1">MSPENRGKHLKRWSGVVAWALFVAIVATGCARLPYTTKVVQENRRVFVSLQREPKPEGYSHPVQFTVEELTAILSGFSFREKQRLPLRWFAEEVPPREIFRRDELEAIVPPLVDALQKASPEERVYFQVLAPGMNPAYERDTTAGWIAIHEPYFHLTLEHYHAMFPTRKSEQWDLRYPALPPDPKTFLLYFEPGRFWETDPVTHRPSVQYREFLKAVPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I840</accession>
    <name>A0A1W1I840_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49192">
        <property type="protein sequence ID" value="SLM49192"/>
        <property type="gene ID" value="NSJP_3025"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3025"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="67" mass="7923" checksum="A5E35EE9E5BE7B6D" modified="2017-06-07" version="1">MSSRMAGWLIHPEQGLSLSKHRLRTRHEPIVSFVRLMGNRVWQEKRGRTPHQKTRCPCNRDFIASQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I883</accession>
    <name>A0A1W1I883_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49258">
        <property type="protein sequence ID" value="SLM49258"/>
        <property type="gene ID" value="NSJP_3091"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3091"/>
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        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="273" mass="30810" checksum="6863A417912E7049" modified="2017-06-07" version="1">MILKKGEPVRTRGRHVIIRATAVVCLALPLAAFAVERPAPIPVQMPYEMPPAVQHSPAETVPQNTKPLTPEELQRAEALLPLLEGKQEFWAMGEFVHLGEPVVPVLVKALTMPGPRIRYNAIETLSMLKAPAAVPVLITTAKDPNEMPRVREHALRVSIRLDPSKTPEAIQAMSKDPNSSIRKAAAFESRYVRDKAVVPILIDMIADDERFVGLSAVQSLWILTRHETEFHDWDSSTKQDRTEWTREWTDWWNIEKDSFQLPEPKRRSTAQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8G7</accession>
    <name>A0A1W1I8G7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49285">
        <property type="protein sequence ID" value="SLM49285"/>
        <property type="gene ID" value="NSJP_3118"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3118"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="99" mass="11006" checksum="3CD6C92501EB85A0" modified="2017-06-07" version="1">MRTTSPNSSTDEVDAIDFSFPGSGNWIGELEERHVPVNMDPSKKRRRTAAPATQSDPAAKPTSPGHYGDETEEDRQKALADAENKNLWDATEVIDMDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8P9</accession>
    <name>A0A1W1I8P9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49386">
        <property type="protein sequence ID" value="SLM49386"/>
        <property type="gene ID" value="NSJP_3219"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3219"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013366009" evidence="1">
        <location>
            <begin position="30"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="219" mass="24068" checksum="6F0536F4623FE60A" modified="2017-06-07" version="1">MAHLPSRRWFLGVCAAALLMGGCTGPAYVPEITVAEARPIVDATAEFHGLFPARALVSGKRTYGLDAPKARRQPPTELTRQLEQEMLKELAAAGVFSRVTGFDPKPDVIIAGRIDAFHEEYRPRAWTYVPILDKQLVSRLLNLKSHTSTGEASLTLFVLTPDGALIGTYEGRSTFDEQFNPTNEVPPGARLNRALSDAVKDIQDQIVRDAQLRKLASRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8U6</accession>
    <name>A0A1W1I8U6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Histone acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3046</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.48" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3046"/>
    <dbReference type="EnsemblBacteria" id="SLM49213">
        <property type="protein sequence ID" value="SLM49213"/>
        <property type="gene ID" value="NSJP_3046"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3046"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012370790" evidence="5">
        <location>
            <begin position="33"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="40"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="250"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="292"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1037" mass="110950" checksum="C10B91E461CFEB13" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Y4</accession>
    <name>A0A1W1I8Y4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">msrB</name>
        <name evidence="5" type="ORF">NSJP_3172</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3172"/>
    <dbReference type="EnsemblBacteria" id="SLM49339">
        <property type="protein sequence ID" value="SLM49339"/>
        <property type="gene ID" value="NSJP_3172"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3172"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="4">
        <location>
            <begin position="17"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="139" mass="15806" checksum="2FC9C95A3FA50533" modified="2017-06-07" version="1">MPQKIEIGPIVKVVKTDEEWKKLLPGDAYRVLRHEDTERPFVNPLHENHEAGIYYCAGCQLPLFSSDHKFDSGTGWPSFWQPIDPKVIETTTDFKLVFPRTEIHCARCEGHQGHVFKDGPKPTGLRYCINGVALKFVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I932</accession>
    <name>A0A1W1I932_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3222"/>
    <dbReference type="EnsemblBacteria" id="SLM49389">
        <property type="protein sequence ID" value="SLM49389"/>
        <property type="gene ID" value="NSJP_3222"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3222"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037873">
        <property type="entry name" value="BamE-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="131" mass="14697" checksum="5B5F08E91FCA892F" modified="2017-06-07" version="1">MNYKWVLWGLCLSIGLAGCGGSQPAEIKDERLTVGRVQSEIKVGMPASQVVEILGSPNIVTTDEKRREVWMYDKVSTDRVDTASSSYGTLIILGKNSRDASSSQRQRTLTIIIKYDDDKKVRDLAYNYTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I941</accession>
    <name>A0A1W1I941_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RND efflux system, membrane fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ttgA</name>
        <name evidence="4" type="ORF">NSJP_3284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3284"/>
    <dbReference type="EnsemblBacteria" id="SLM49451">
        <property type="protein sequence ID" value="SLM49451"/>
        <property type="gene ID" value="NSJP_3284"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3284"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="62"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="399" mass="43387" checksum="4113D0A524B84D0A" modified="2017-06-07" version="1">MNLDWNARQQSAACLLAIFITTFLFGCKGEVASSPPPQALEIGVVTVTPTSVPDEPEFIGQAEASRIVEIRSQVTGIIQERFFQEGREVKKGDRLYRIDEVPFRAAVVSAKGRVAQSEARFVHAKQDLARVKPLLEQDAVSQKDFDDAVAEQLAAKAALETAHGDLDKAKFDLDNTVIAAPISGLVERTRVYEGRLVSAQTDLLTVIHQIDPMYVVVNAPEAFLIKRREDTAAKKIQHPGVYKLTGTLIFLNGSRYAEDGVLDLLDVGLRSDTGERPARVTFPNHDGIIIPGQFVTVRFHGVTRSSVMLIPQRAVLQGPKGPIVYVVDADNNVQIRDVKATAWQGTQWLVEDGLVAGERVVVDSLQRVVPGTAVKPVPVETEAGSSGSPPSDPKSQTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I966</accession>
    <name>A0A1W1I966_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Elongation factor G (EF-G)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fusA</name>
        <name evidence="5" type="ORF">NSJP_3387</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3387"/>
    <dbReference type="EnsemblBacteria" id="SLM49554">
        <property type="protein sequence ID" value="SLM49554"/>
        <property type="gene ID" value="NSJP_3387"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3387"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="7"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="700" mass="75937" checksum="604B67B71472884F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I968</accession>
    <name>A0A1W1I968_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49429">
        <property type="protein sequence ID" value="SLM49429"/>
        <property type="gene ID" value="NSJP_3262"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3262"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="57" mass="6374" checksum="6D3633211A5D1F7A" modified="2017-06-07" version="1">MTVDRNVAFQQHLPQFAIAVVLLQAPTNRLKDLRALLPELHRILPTAPKSQMTVVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9G7</accession>
    <name>A0A1W1I9G7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="2">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">fcl</name>
        <name evidence="4" type="ORF">NSJP_3458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:18885"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.271"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49625">
        <property type="protein sequence ID" value="SLM49625"/>
        <property type="gene ID" value="NSJP_3458"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3458"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="17"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="170"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="323" mass="36083" checksum="0757406D9E18BB88" modified="2017-06-07" version="1">MSESSGVWDNKRVVVTGGAGFLGSYVVGRLQERGCSQVIVPRSRQYDLVQMAAVQQLYADARPDVVIHLAARVGGIGANQANPGRFFYDNLMMGTQLIEIGRQRGLKKFVALGTICAYPKFAPIPFKEDDIWSGYPEETNAPYGLAKKMMLVQSQAYRQQYGFNSIVLFPVNLYGPRDNFDLETSHVIPALIRKCAQAKEAGGSSFTLWGDGSPSREFLYVEDAAEGILSAAETYDGDMPVNLGTGEEVTIRNLAELIADEVGFKGRIEWDTTKPNGQPRRCLDVNRAKQLFGFQARHNLRDGLRKTIRWFFDNRHALREVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9L6</accession>
    <name>A0A1W1I9L6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formate hydrogenlyase, membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hyfF</name>
        <name evidence="4" type="ORF">NSJP_3392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3392"/>
    <dbReference type="EnsemblBacteria" id="SLM49559">
        <property type="protein sequence ID" value="SLM49559"/>
        <property type="gene ID" value="NSJP_3392"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3392"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="130"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="504" mass="53806" checksum="FA713EF463B4D273" modified="2017-06-07" version="1">MSAAMTTVAVAVLLCAPFTAGCWSLFIRTSRQLHLINLGSMGLLVAAEILIARTVLIRGAVTAFDELVYIDALSSVILFIIGTVGLACSLYMRSYLDEQVARGTIAPNRLNMFFFLFHMFLLAMVLATVANSLGVQWVAIEATTLATTFLIAFWRRRESLEAGWKYLILCSVGISLALFGVVLMYYSSLRVLGDVSLALNITQLQEIAARLDPHIVKLAFVFLFVGYGTKVGLVPMHSWLPDAYSEAPAPVAAMLAGVLETVAVYAILRSRGIVDQAVSPEFSGNLLALFGLLSFAIAALFLLLQHNYKRLLAYSSIEHMGLAMVGFGVGGPVGTFGGLFHLVNHAFAKALAFFAAGNIHRRYKTVEIGEVQGLVSVMPGSALALMVAGLALAALPPFALFASEMQIITALASSGLPGKWGGQGVGGSVLLLLLCSLVAFSGFLYRITGMVWGPAPQAVEQGESWSAGHFSLLFLGLLLVGLCWVLPAPLRQLLEAASALLAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9U9</accession>
    <name>A0A1W1I9U9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49770">
        <property type="protein sequence ID" value="SLM49770"/>
        <property type="gene ID" value="NSJP_3603"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3603"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="153" mass="16981" checksum="A9BA5647FC2C1760" modified="2017-06-07" version="1">MVKALHYLAVVVLVLGAAYFIWTKPPVVNPMIDRRSADALALVQTHRALGYPTILQAMTEHVRSMKDRGLNARLGEWRVKQVDGDLYEIRVQLRDQGVSGQWFEREFIWHANLSLKKVNAASLPADGVTPKEPDQTDPSGPSVPQFPGARGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9V3</accession>
    <name>A0A1W1I9V3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49828">
        <property type="protein sequence ID" value="SLM49828"/>
        <property type="gene ID" value="NSJP_3661"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3661"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="124" mass="14343" checksum="D6D316E5AB200648" modified="2017-06-07" version="1">MRRHIGVCHTGLPRSHAHDVRQDRVVPFLWCHGIGTARPQDQRLRALAVRVLPMAMQKMPGTIPHTAARPADFDCLTGLRSFSARIPLEAEAYHETQLYRPLRLSGVWCELQTMERRRSVWTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Z0</accession>
    <name>A0A1W1I9Z0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1 3">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 5" type="primary">ndk</name>
        <name evidence="5" type="ORF">NSJP_3564</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1 3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3564"/>
    <dbReference type="EnsemblBacteria" id="SLM49731">
        <property type="protein sequence ID" value="SLM49731"/>
        <property type="gene ID" value="NSJP_3564"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3564"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="4">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="139" mass="15130" checksum="10533D2794C630B6" modified="2017-06-07" version="1">MSERTLAIIKPDAVKKQAIGDIISQYEQAGLRPVAMRMLVMGKGIAEGFYAVHRARPFFDSLCTFMSSGPVVVLVLKGENAIKKNRELMGATDPAKADKGTIRAKHGTNIEYNAVHGSDSPETARVEIAYFFPEMSVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA32</accession>
    <name>A0A1W1IA32_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49850">
        <property type="protein sequence ID" value="SLM49850"/>
        <property type="gene ID" value="NSJP_3683"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3683"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="52" mass="5996" checksum="D903024DE2E80710" modified="2017-06-07" version="1">MITNPGEAYSKLGFSGTALELLHNVIRGQGRLLWRYRVRCFIRDQPPSRAFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAF1</accession>
    <name>A0A1W1IAF1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hemD</name>
        <name evidence="9" type="ORF">NSJP_3576</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3576"/>
    <dbReference type="EnsemblBacteria" id="SLM49743">
        <property type="protein sequence ID" value="SLM49743"/>
        <property type="gene ID" value="NSJP_3576"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3576"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="9"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="HEM4" evidence="8">
        <location>
            <begin position="272"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="520" mass="55961" checksum="8467511A445DCDB4" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAS1</accession>
    <name>A0A1W1IAS1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3706"/>
    <dbReference type="EnsemblBacteria" id="SLM49873">
        <property type="protein sequence ID" value="SLM49873"/>
        <property type="gene ID" value="NSJP_3706"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3706"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipase_3" evidence="1">
        <location>
            <begin position="99"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="291" mass="32065" checksum="B70A4E4719874FDD" modified="2017-06-07" version="1">MKSTRVFTVPSGLALAVVGLVLAGLPSCGSHKPIESVPSAPPDFSRVLQYAQRADLAYQQDEVIRQQSGTSVRVSVSPPLASGVKAYVEVDDAARVQWIVIRGTSNLVNIRADVDYNKVVESRLQIPLHKGFGDAALQVYQFAKPLLKTDYETRVTGHSYGGAAAVVVLMLLKEDGIRLGQAVTFGQPKVTNRAGVRKYGSLPLIRYVNDKDPVPLLPPFEVFAVLDEGPFQHLGPEVVLEDGKRYRYYAEHQAEHSSVLSFWNNLKNLSIQDVPEHFMATYLARIKQLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAV5</accession>
    <name>A0A1W1IAV5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3862"/>
    <dbReference type="EnsemblBacteria" id="SLM50029">
        <property type="protein sequence ID" value="SLM50029"/>
        <property type="gene ID" value="NSJP_3862"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3862"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="427" mass="48019" checksum="DD3D45B8390545B2" modified="2017-06-07" version="1">MTPWTLALVFLTALTALGLWSEPSSRAADADALAPLIFQYLDSQNSDEAERLLRAITARPDASIETVTQIVQTEYPYSSQPIGTLPDEQVVVDGRSYQLALSIPLTYQPSKGYALVVCLHGAGFTGEAYLERWRARLEDEYLLACPTYPGGAWFTKRAETLVLASIKQVRRRYHVDPDQIFLTGMSNGGIGTWLIGMHHAPLFAGIAPMASGLDQVLMPFLANLRNTPVYMIHGEKDQVMPVELSRSISRELTALGYPHVYREHQGEHPVAGGHYFPREELPELAAWLNRQRRDPLPARLTVVREASHFQPFDWVRLDATDPIAAFADDLVSKRDESIRRREYAKLDATIVAPDRIDVTTERIRRYSLFLNEGMIDVTKPLTVSTNGKVSFEGLVTPSVEHLLRQMRLRDDPRQLFSIHLTISTQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB25</accession>
    <name>A0A1W1IB25_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">glmS</name>
        <name evidence="11" type="ORF">NSJP_4090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4090"/>
    <dbReference type="EnsemblBacteria" id="SLM50257">
        <property type="protein sequence ID" value="SLM50257"/>
        <property type="gene ID" value="NSJP_4090"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4090"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="286"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="458"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM50257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="609" mass="66741" checksum="D2056290AF02A0F2" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB87</accession>
    <name>A0A1W1IB87_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50033">
        <property type="protein sequence ID" value="SLM50033"/>
        <property type="gene ID" value="NSJP_3866"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3866"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="176" mass="19767" checksum="D8784740894214D8" modified="2017-06-07" version="1">MCPWVRGMERPYPTIEPGEPASRESRAPVAKVRQYTMLVTLGLIVLCNGILIFGVWVSGVNLDELVKTPDLFNATKDVCLRLTWERVPGASEPVRLCSEWINLADPSGAPHHLASDLKVRQGPDGRYYFDQSIRPDFRLLALALFVGAVLLFGLWARRYLVSRYRLQLEAAAPRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB96</accession>
    <name>A0A1W1IB96_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50169">
        <property type="protein sequence ID" value="SLM50169"/>
        <property type="gene ID" value="NSJP_4002"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4002"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="167" mass="18504" checksum="C1ACC8CD0CE9CB76" modified="2017-06-07" version="1">MWLWSTTEEPPRMPLTNVSGRHSAQQGRNDHGSGLHVQLDLLTSSRDQRNLSFVMPRNIFSLPGMAEAAGPSSDAVPDTAQQQQVILTELAQFHYLGFVRKEGGDREKARDLAVLTKNDDVYVAGKGEILENHVIVKLITPDSVMLQDRNSHLEYAVPLSEESASEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBF1</accession>
    <name>A0A1W1IBF1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_4074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50241">
        <property type="protein sequence ID" value="SLM50241"/>
        <property type="gene ID" value="NSJP_4074"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4074"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="109"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="173" mass="19542" checksum="C658DCA70870C0D0" modified="2017-06-07" version="1">MQLLHMNRQASELARQINLAEHGGNSSRPAHGVLPSVLTELCGEIVKALHVRTEAKDWEQFEIKRVTGNPEQPVLLRGFGLPDRGGVQFARLVVTLEELGRRQQLNTDQAKEKFQLTNREQAVVEHLAKGWTNKEIANALQITEQTVKEHIKHIMRKTNATTRTGILVQIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZW7</accession>
    <name>A0A1W1HZW7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fused response regulator of ato opeon, in two-component system with AtoS: response regulator sigma54 interaction protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">atoC</name>
        <name evidence="8" type="ORF">NSJP_0119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0119"/>
    <dbReference type="EnsemblBacteria" id="SLM46291">
        <property type="protein sequence ID" value="SLM46291"/>
        <property type="gene ID" value="NSJP_0119"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0119"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="144"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="482" mass="53064" checksum="5E57A00BA220B96F" modified="2017-06-07" version="1">MKGLTILLVDDEPLMRLSMVDAMEAVGYEVRAASTGTEGIQLLRQNPFDLVITDLRLPGADGLAVLKATKEAAPETEVVVITAHGSMETAVGAMRLGAFDYITKPFQMDELLLIVERVGRVVRLRRETEESKEIHDDNFRFGGILGANSRMREVLDKVRTAAGSDVPVLILGESGTGKELVANAIHQNSPRNHHPLIKVSCGALSEALLDAELFGHEKGAFAGASRQRRGRFELAHRGTLFLDEISELPAGIQDKVLRLLQERKFWRLGGRESIEVDVRLVGATRVDLAQAVEKGRFHEDLYRRLNTVQVTLPPLRQRTDDIMIIADHLLHDYSSRMNKRLKGFSPSARDLLSRYSFPGNVRELEKIIERGVTTGRDHEMVHPADLCEFPSCPFTGGGPQESCGFCHEGLAAESKSKGVSLTSLSAAREEFEKSHILSVLERVEGNRTAAAKVLGLSRKALGDKCKRYGIPSVTEDAGEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I045</accession>
    <name>A0A1W1I045_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46375">
        <property type="protein sequence ID" value="SLM46375"/>
        <property type="gene ID" value="NSJP_0203"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0203"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="101" mass="11342" checksum="1760FB08B7D49709" modified="2017-06-07" version="1">MQMLMVVFRSSLKERVHELLHKCDVRAFTEVNQTIGYGQTGPADGLSFFPGTNTVILVSLDDDHVTRVTNSVLAWCEEAAKHPGWKKPALRVFAWPCTQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I051</accession>
    <name>A0A1W1I051_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA polymerase IV, family X (N-terminal)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0051"/>
    <dbReference type="EnsemblBacteria" id="SLM46223">
        <property type="protein sequence ID" value="SLM46223"/>
        <property type="gene ID" value="NSJP_0051"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0051"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="DNA_pol_b-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="PTHR11276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="SSF47802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HHH_8" evidence="1">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="164" mass="18223" checksum="302648A327C2D5EF" modified="2017-06-07" version="1">MHTPINNQKIAATFRAMAELLASRRANPYRVRAYRRAADSVLSLEEDLASVAQRQALEDIDGIGRELAEKIEEFLRTGTVKSYESLKTPLPDPVKEWAALPGLSDSLVTYLYTRLSITTLEDLERLVRSHMLRTVPGFTGPEDALLNAIASLRSRTQPTTDAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I076</accession>
    <name>A0A1W1I076_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46289">
        <property type="protein sequence ID" value="SLM46289"/>
        <property type="gene ID" value="NSJP_0117"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0117"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="81" mass="9179" checksum="7D39FE30A40FFFD3" modified="2017-06-07" version="1">MMRWLVNRRQPVRLQMVVLGQYNFSLNGTIVREARSSSQAAVMAHFEIGERYGTSLSARLVAGSYRLLRGKDGTGRRSHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I091</accession>
    <name>A0A1W1I091_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="7">2.7.8.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_0232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0232"/>
    <dbReference type="EnsemblBacteria" id="SLM46404">
        <property type="protein sequence ID" value="SLM46404"/>
        <property type="gene ID" value="NSJP_0232"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0232"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="347" mass="37751" checksum="58A394D13324518F" modified="2017-06-07" version="1">MTYLSILTLILGFLLASYGVPIARTAALKYGIVDAPDGRLKHQREPVPYFGGLAIYLAFLMSLAFTFEFRHDVLGIILGGTIVVMLGLIDDFGVLTPWTKLAGQLLAVFVLIKSGIRIEIAAFPEWLDLILTVFWMVGLINAFNLLDIMDGLSAGVGAVSAMFLLIVAVLQNDQTMVFMLAALIGSLVGFLRYNWQPARIYMGDTGAMFIGLLLGAMTMIEKYPSAHPFSLLTPVFILGIPIFDTLFVMYVRYQRGLPIFWGSPDHIAIRLRHWGMSVPQVVIASYAATACVAGIGLLVMSANEQVAMGLCLGTAAVLLAATAVLKRLDVRRPDHAPGKPEEERTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0G9</accession>
    <name>A0A1W1I0G9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0328"/>
    <dbReference type="EnsemblBacteria" id="SLM46500">
        <property type="protein sequence ID" value="SLM46500"/>
        <property type="gene ID" value="NSJP_0328"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0328"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="11"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="478" mass="54178" checksum="F9B1E8786422D579" modified="2017-06-07" version="1">MTSRTARKTILVLIHGFISDHRCWDSLRHLLETDARIAERFDIECFDYPTSLLGKGSEHAHPSLRQVAGQLNEFLAQPRFAGHPLVLVGHSQGGLVIQAYFVLLLEAHHARQLSRIRQAIFIATPNLGSVFLDRTRRLTDHVLKVLGGSFLHPQERLLRALQPEIMEIQKLLLGNIVAAVSHSDQACPIPLQCFYGSADRIVLDVSAQSFFAPDVCMPLPAGHMDIIRPQDTEDERYAKLTDAILHPIGHVNVVEVERYDTTLRVEPYDGTKGVEVSYGSSRRSVFTDNRAVLSRRMAISRKNRCRNSCDMSYLTNAEGFIKPIPAEMLERLERKDLTRYESQGREFNFVFAPSPGETYDVTLEILRGFEAGDRRVHFHLGASCYHQVLTYRLDLTAYVRAGYRMTGRPRLYFEEGETHRCDEIWASQPLEATTSDDHGLWYWELHDVRHGAIGLAWDLAPDATTAEETSSATAEYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0I3</accession>
    <name>A0A1W1I0I3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative Mechanosensitive ion channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NSJP_0315</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0315"/>
    <dbReference type="EnsemblBacteria" id="SLM46487">
        <property type="protein sequence ID" value="SLM46487"/>
        <property type="gene ID" value="NSJP_0315"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0315"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012709510" evidence="9">
        <location>
            <begin position="25"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="563"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="58"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="172"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM46487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="796" mass="89243" checksum="50451D951D103BE3" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0L9</accession>
    <name>A0A1W1I0L9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46545">
        <property type="protein sequence ID" value="SLM46545"/>
        <property type="gene ID" value="NSJP_0373"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0373"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013162026" evidence="1">
        <location>
            <begin position="27"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="238" mass="27627" checksum="82B689B508B8CB9E" modified="2017-06-07" version="1">MREMGRYMLLGLVVMLPTFTFFTEHAADAHEWLGTCYVDWDNHFALTNVYAQARTTFAVPTGISPSGQREPCNDGHAACWTYRHRCFNDYINVEPMNYGHFHLSFEDPDMDCFTPDPGDGLGGGFGRGTPASCPVVDWTNERRVMHSHVQDHWIKIWLEDRVSHKPRVFDLPWIWVAGDQPIQFWFKKTDGSWWYWSELNHSTIWNVSTWVHDVVEVRIRGANSGFGPYTLNGFYVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0N1</accession>
    <name>A0A1W1I0N1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46556">
        <property type="protein sequence ID" value="SLM46556"/>
        <property type="gene ID" value="NSJP_0384"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0384"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="38" mass="4030" checksum="36DA6C133981EC13" modified="2017-06-07" version="1">MKAVVQGSGTSGTESSHVPPCEKVVLTIHPVLLRQVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0S2</accession>
    <name>A0A1W1I0S2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="5">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase I</fullName>
            <shortName evidence="5">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">folE</name>
        <name evidence="7" type="ORF">NSJP_0405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0405"/>
    <dbReference type="EnsemblBacteria" id="SLM46577">
        <property type="protein sequence ID" value="SLM46577"/>
        <property type="gene ID" value="NSJP_0405"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0405"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="6">
        <location>
            <begin position="28"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="213" mass="24086" checksum="472D50C88163FF70" modified="2017-06-07" version="1">MAKLRRRTLQRIEDLPPVKRPADEGHIQSLVAQLLKALGETPSRNGLLKTPERVAKALQFMTRGYHQNIDHLLNGALFPIEYDEMVIVKDIDFFSMCEHHMLPFFGKCHVGYLPNKKVVGLSKIPRVVDAFSRRLQVQERLTTQIAETLKQKLNAHGVGVVMEAQHLCMMMRGVEKQNTIAVTSSMLGAFRTQQQTRAEFLKLISRNGVGDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0T0</accession>
    <name>A0A1W1I0T0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0434"/>
    <dbReference type="EnsemblBacteria" id="SLM46606">
        <property type="protein sequence ID" value="SLM46606"/>
        <property type="gene ID" value="NSJP_0434"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0434"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="SSF82657"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="79" mass="9013" checksum="72D93FCEB37831CA" modified="2017-06-07" version="1">MITAETLTDYIRRTMPDAAVTMTDRTGTMDHLKVVVVSEVFRGKNLLDRHRLIYQALDAPMKDGRIHALELTARTKDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0U3</accession>
    <name>A0A1W1I0U3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-(Acyl-carrier-protein) reductase</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG</name>
        <name evidence="1" type="ORF">NSJP_0430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0430"/>
    <dbReference type="EnsemblBacteria" id="SLM46602">
        <property type="protein sequence ID" value="SLM46602"/>
        <property type="gene ID" value="NSJP_0430"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0430"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="244" mass="26108" checksum="44557B3762254E95" modified="2017-06-07" version="1">MTHRVALITGGAKGIGRGIALDLAQQQWCVAICYRTSAAEAEETARAIEARGGRALTRRCDVSEPTAAREFAATVEKEWGHIDALINGAGPYHRVNLFDETVAGWNEMFDGNLHPIFYLAQAVAPGMKARKYGRIITFSMANTEQMVSQPDVTAHYIAKAGVLILTRTLAKLLAPHGITVNTISPGFIDSGSAPPEELAGMTKRIPAGYIGTVDDVVAAVRFLLGDDARYVNGANIQISGAWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0W5</accession>
    <name>A0A1W1I0W5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative rRNA methyltransferase YqxC</fullName>
            <ecNumber evidence="3">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yqxC</name>
        <name evidence="3" type="ORF">NSJP_0476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0476"/>
    <dbReference type="EnsemblBacteria" id="SLM46648">
        <property type="protein sequence ID" value="SLM46648"/>
        <property type="gene ID" value="NSJP_0476"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0476"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="254" mass="27122" checksum="53F6A9958CD54A86" modified="2017-06-07" version="1">MTSPRHSSRERLDTLLVSLGLAPSRENAVRTVLAGGVLVDGNVVDKPAKLVARDARVEVCRPAPFVSRAGEKLAPALEAFSIDPKGAICLDVGCSTGGFTDCLLQRGAVKVYAVDVGYGQLAWKLRQDPRVVLLERTNIRYLDPSLVRELIQLAVIDVSFISLSLVLPSVVRFLQDGARVVALVKPQFEVGKGEVGSGGIVRDDGQRADAAKKVMACAAGLGLPAIGMQEATVKGRKGNREILVAFEYRSKMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0W6</accession>
    <name>A0A1W1I0W6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="3">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="3">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">xseB</name>
        <name evidence="4" type="ORF">NSJP_0478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the XseB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0478"/>
    <dbReference type="EnsemblBacteria" id="SLM46650">
        <property type="protein sequence ID" value="SLM46650"/>
        <property type="gene ID" value="NSJP_0478"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0478"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="84" mass="9275" checksum="90834C8DB3299D2B" modified="2017-06-07" version="1">MKFEQAIARLESIVGELEKGDLPLDESLKIFEEGIRLSKSCLKILEDAERKVEVLVQEQNGKKRLHAFTQDLGDGSSSSGSNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Z4</accession>
    <name>A0A1W1I0Z4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Soluble lytic murein transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0485"/>
    <dbReference type="EnsemblBacteria" id="SLM46657">
        <property type="protein sequence ID" value="SLM46657"/>
        <property type="gene ID" value="NSJP_0485"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0485"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008939">
        <property type="entry name" value="Lytic_TGlycosylase_superhlx_U"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48435">
        <property type="entry name" value="SSF48435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="3">
        <location>
            <begin position="638"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="792" mass="87616" checksum="A147037AB8A47EAB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I156</accession>
    <name>A0A1W1I156_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC-type transport system, ATPase component</fullName>
            <ecNumber evidence="7">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_0401</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0401"/>
    <dbReference type="EnsemblBacteria" id="SLM46573">
        <property type="protein sequence ID" value="SLM46573"/>
        <property type="gene ID" value="NSJP_0401"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0401"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="2"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="279"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="311"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="622" mass="69974" checksum="510107A42ACF4DEE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I199</accession>
    <name>A0A1W1I199_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46613">
        <property type="protein sequence ID" value="SLM46613"/>
        <property type="gene ID" value="NSJP_0441"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0441"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35024">
        <property type="entry name" value="PTHR35024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="147" mass="15682" checksum="828650BAA5250B46" modified="2017-06-07" version="1">MKKNGFSGDDNITLLARGVQLRGEIRVEGTVRIDGRLEGDIHTNGQVIIGEEGLVQGTIDAGVVVSSGRIKAKVTASERVQLLKTAVLIGEIHAPVLMMEEGAKLQGSTDMGVASWPDELPKLPGTVHELSTHRSKHVVVLDKESNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1A7</accession>
    <name>A0A1W1I1A7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46777">
        <property type="protein sequence ID" value="SLM46777"/>
        <property type="gene ID" value="NSJP_0605"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0605"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="216" mass="24264" checksum="A04F0A1C90330AA0" modified="2017-06-07" version="1">MPKRKKPSIPPSEVTDHPPSSLMNPISYTDPPECKISFQTRRHISRSKSLATSAPRLVLDDLEHLVQAVQGTSRQQWFNRFGTKLCDGTPLDRIKFCFQALAFGALPDAETLEYVVASFSKYVNSDGTLSLDEAFGLKSKPKAGNPVRQAIRKNAINGLLFSMMCARYQNPRLSLEKAAEGAIKVHGSPNNKDITDTLVREYVRRRYDKAMKLHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1D5</accession>
    <name>A0A1W1I1D5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46679">
        <property type="protein sequence ID" value="SLM46679"/>
        <property type="gene ID" value="NSJP_0507"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0507"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="311" mass="35642" checksum="715B2AD2933CA6CB" modified="2017-06-07" version="1">MDKGKALIAKLKDVGREAGMLGLHGLVVVLSAGIAWSLPNIARQFLTFWSRVEHEQVLLLAMEVCVALCLIAVSSYLWQAFQDRRQAVMARGAGLISFFSSHNPVADRAIRRLKQEQSLGRTVLAIGVTGHGTVIDDKAEIHALLETCLEAKLILLNPFSEEAVRRAQSLSHLDVTPARLRDELVETISLIKRLRAAGKVIRLKLYSDRPHVRMIILGDYLWLQHYHTGLDVRWMPEYVFQHKVDHHGLYTLFYQYFTKRWENQDIPEYDFQTNELVYRTRNGSELRREPFGLDQAESHEERDLAAAEPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1F6</accession>
    <name>A0A1W1I1F6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphopantetheine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0666"/>
    <dbReference type="EnsemblBacteria" id="SLM46838">
        <property type="protein sequence ID" value="SLM46838"/>
        <property type="gene ID" value="NSJP_0666"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0666"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="93" mass="10188" checksum="B5D6C0731361F9A9" modified="2017-06-07" version="1">MPTQVKQESACDAISESDLARLIVDTLHLELDVKDVDPAAPLFGDGLGLDSIDMLEIVLSISKKYGVALRSEDRPAFTSIRALTAHINRQRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1G8</accession>
    <name>A0A1W1I1G8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0660"/>
    <dbReference type="EnsemblBacteria" id="SLM46832">
        <property type="protein sequence ID" value="SLM46832"/>
        <property type="gene ID" value="NSJP_0660"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0660"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="5"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="396" mass="41939" checksum="CA4ABD4FBAC2AB1C" modified="2017-06-07" version="1">MMPPLAMTALATANPLGLGLQATWNALSESRHGLRPNDFLDVTVKTWIGRIAGIEEEPITGSFGAWDCRNNRLALLGMQQDGFERAVNAARQRYGSARVGVVLGTTTSGILETELAYRRRTADGKLPDVIRYRYQQNLFSVTEFVQRYLGLTGPAVSVSTACASSARVFASAARWIHAGLCDAVVVGGVDSLCLMTLYGFASLGLLSDEPCRPCDVARNGLSIGEAAGFALLERPGPAAADVVLLGYGESSDAYHMSTPQPEGQGAALAMEQALSRAGLQPSDIDYVNLHGTGTQANDRAEDEAVSRVFGRQTSCSSTKGATGHTLGAAGITEAIIVALALRHDRIPGTVNTEVLDPRLRARIELIGMRRSLRQAVSNSFGFGGCNCSLVFGKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1I1</accession>
    <name>A0A1W1I1I1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46855">
        <property type="protein sequence ID" value="SLM46855"/>
        <property type="gene ID" value="NSJP_0683"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0683"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="143" mass="15386" checksum="D8600552E9E8BCFB" modified="2017-06-07" version="1">MASDGSAAILIIDGNHQDRVHYAGLLRNSSPDYEIFQAGDGKSGLERCQGRLFDCVVLELDLPDMSGFEVLRELIPLRECPGIPVVVLTRLSNDALLSAAVLYGAQACLQKQQASADLLDQAVTKSMSAVGHFRRRGAVRSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1N7</accession>
    <name>A0A1W1I1N7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_0607</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46779">
        <property type="protein sequence ID" value="SLM46779"/>
        <property type="gene ID" value="NSJP_0607"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0607"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="151"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="332"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="381" mass="43912" checksum="BF3B1C47CACAC3F0" modified="2017-06-07" version="1">MHAHLLDEPMEATLPALNTIQEAYETACLAGHRFPEPDDAELWRRCKATWCFREWIELYRRYHMVNFAEATRLVIDCRLNKHFGPLVPLKPELITRNVLLHFSTELAKHSPTVARMSLKLITAIFYKAIDWGVWSGQNPASRIPKPPRQFRTRFVQPGEELRRLLVVLNQEPDDIRAFFLTVLLTGCRKGELQRMQWKDLDLVNGLWHKPAGTVKNRKPQTTPLPRTLIPFLDRLPRLNTWVFEAPHNLGRWKEMYVFNTWKRIRTRAHLPDCTIHDLRRTFASYLAMGGTSSSVIAKALGHSDLQHVHIYARLDVNSVRSAVDAQADTIMNLHNMTPPPTAGPRPTRPRTRREPQPSAEPVEMPPAPPQTQRDPATDWPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I209</accession>
    <name>A0A1W1I209_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47024">
        <property type="protein sequence ID" value="SLM47024"/>
        <property type="gene ID" value="NSJP_0852"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0852"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="55" mass="6053" checksum="C49262D162C9C82C" modified="2017-06-07" version="1">MVLMIGLVTMTTLIWVLAHSLAGESEAEKRRLSLESRYTIPTTPAETRGRLPLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I256</accession>
    <name>A0A1W1I256_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0918"/>
    <dbReference type="EnsemblBacteria" id="SLM47090">
        <property type="protein sequence ID" value="SLM47090"/>
        <property type="gene ID" value="NSJP_0918"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0918"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014082">
        <property type="entry name" value="CRISPR-assoc_prot_Cas02710"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02710">
        <property type="entry name" value="TIGR02710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="418" mass="45888" checksum="9DCC708910954814" modified="2017-06-07" version="1">MAQEQPVQALVVALTEEVAGAVYSLNRLRPDAACFVLPESAKPLVEHDLQPKLSQVPRRWDWIVVPDVESFPSCYVTIARSLPALLETWGIESGSLVLDLSGATAAMAAGLTLAALPHASRVVSIIGAQEGREGETVTLDGMEKQWVQANPWDEAARGMRREGCSLFNRGALAAAAAVFRQIEHRVSGGLKPLYRALADLADGYDLWERLQHRHAWEKLKTSIKALEMATLFGGPAEVKSCLPAIKANSGFLEKLVLDPSEVKESVAVDLLAHAGRRLRVTNDAEGAMRSLLRALEALAQRRLFTAHGIKTWDVRPEQLPQALQENCRVCHLDDIDGKYRLPLQAQFRALAGLGDQLGQSFLREWPTMKPLLDAANRGILGHGFEPVKAERVQQLYDVVVRLAGSNESTLPRFPTLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2K7</accession>
    <name>A0A1W1I2K7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RND efflux system, outer membrane factor lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ttgC</name>
        <name evidence="4" type="ORF">NSJP_1039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1039"/>
    <dbReference type="EnsemblBacteria" id="SLM47211">
        <property type="protein sequence ID" value="SLM47211"/>
        <property type="gene ID" value="NSJP_1039"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1039"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011821043" evidence="2">
        <location>
            <begin position="18"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="475" mass="52925" checksum="25FBAB23DC497F84" modified="2017-06-07" version="1">MRTILFLLSAVVLASCAIGPDYQRPADPAIDKFRMAETTTDANSIANMPWWELLKDEELQRLVRTALDENRDLRRAIASVEEFQSRVFISRMDYAPQMTGTFYAPTAKNSSFAFPGFPNPFNYYLQGNLTWELDIWGRIRRSNEAARADLLSKEESRRAVVLQLVSGVAEAYFDLLQFDMQLQIARDTVKSWEESVRIAQARLRQGMTNKLDLDQFESERANAVARTAELERLMVQKENQISVLLGHSPKQITRGRSLTEQVIPPEVPPGLPSDLLQRRPDIVQAERDLAASTARIGMAKADRFPKVSLTGLLGIANPQITNLFTPGSDFAALGPTITGPLLNAQVLGFQQEAAEAQARQSLAQYEQSVLVAFREVEDALVAVRTVRDQRQAQIQRVDALRSAFRLAELRYKGGLASYLDVLVARRTLFEAELSLTETHRLHLVSVVQLYKALGGGWSPETAGENSGSTGQKSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2M5</accession>
    <name>A0A1W1I2M5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47221">
        <property type="protein sequence ID" value="SLM47221"/>
        <property type="gene ID" value="NSJP_1049"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1049"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="343" mass="38159" checksum="720BD04EA43D0943" modified="2017-06-07" version="1">MKRYWPGHAGMCAYSNLTEKVGWLIWFFLFGSLHLSFAQEPASPSLEGVRTPSQEQSRGPASTETDHEIDADSGEQGPEDERSVRSRRVVGRLGARPLTLEEQEEAKRLSAIAARMGTDPTAIIGRVQTLFRYDALEGGSRASNLVGRIDVPYHKNFLLRADLPYVWSDPNQPGASSQNGVSDLLVRAGGRVYSDPADTIFAGVDFTFPTAADKLGSGKYTVGPGVATAHVFPTWGSIVFALLQHQFSVGGDPSRNDVSASRLQCWFNTIWTDHWWTQIEAVAQMNWEQKEKTSMTLEFEGGYRFTKDWAVWLRPGVGLWGRSLPGAYDWNFEVGIRRMFAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I314</accession>
    <name>A0A1W1I314_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxygen sensor histidine kinase NreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">NSJP_1189</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47361">
        <property type="protein sequence ID" value="SLM47361"/>
        <property type="gene ID" value="NSJP_1189"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1189"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
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        <property type="project" value="UniProt"/>
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        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="CheY-like_superfamily"/>
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        <property type="entry name" value="GAF"/>
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        <property type="entry name" value="GAF-like_dom_sf"/>
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        <property type="entry name" value="HATPase_C"/>
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    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
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    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
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    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
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    <dbReference type="InterPro" id="IPR035965">
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        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
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        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
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    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="22" id="KW-0418">Kinase</keyword>
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    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 15" id="KW-0597">Phosphoprotein</keyword>
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    <keyword evidence="22" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="381"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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    <feature type="domain" description="Histidine kinase" evidence="18">
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            <begin position="1140"/>
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        </location>
    </feature>
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            <end position="1507"/>
        </location>
    </feature>
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        <location>
            <begin position="633"/>
            <end position="656"/>
        </location>
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        <location>
            <begin position="1091"/>
            <end position="1136"/>
        </location>
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        <location>
            <position position="713"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="15">
        <location>
            <position position="1442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SLM47361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1518" mass="167013" checksum="BA211E011FD81228" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I366</accession>
    <name>A0A1W1I366_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Nitrospiraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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        <property type="gene ID" value="NSJP_1278"/>
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        <property type="entry name" value="ATPgrasp_TupA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="317" mass="36269" checksum="B10560E61208DA3C" modified="2017-06-07" version="1">MNSVDPAWLGSVAAFTGDIRRLMIARFIHQRLRRLAVTLYGRGIPSRLLDAILYPTYLFQFLEVHNRLPVRPNRLFNDFLFKIKSGSELKHPLRRLVTDKELGKIYIEKKLGRGVTPRTHMILRSAAAVDRDTPSVYPSVVKPTHCSGRIVIVRSASEYAAASPTIKNWLQEDYFLDDLEKNYVGLERKVIVEEYIDDSFVLEGSLHCLNGEPKVISLIDRTTKSRQSFDVNAMPLGVSLHFPLQEFEPKSWEFLPQLLESARILASEFDYVRVDFYTDTTRILFGELTHLPAGGTGKFYPANGEMKFSEAFFRSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I372</accession>
    <name>A0A1W1I372_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47411">
        <property type="protein sequence ID" value="SLM47411"/>
        <property type="gene ID" value="NSJP_1239"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1239"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="71" mass="8233" checksum="E73A86FABF6A6BE7" modified="2017-06-07" version="1">MSLNPPPNEKVSVDVFEAAIKTVEEQLGLNNQPRAIVFHENEGRRHAHVVWSRIDTEEMKAIYLPFYKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I388</accession>
    <name>A0A1W1I388_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction response regulator, receiver domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1296"/>
    <dbReference type="EnsemblBacteria" id="SLM47468">
        <property type="protein sequence ID" value="SLM47468"/>
        <property type="gene ID" value="NSJP_1296"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1296"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="151" mass="16727" checksum="5424E8E765ADCECC" modified="2017-06-07" version="1">MTTVKPILLAEDNPRDAELALAAMEEHHIADKVVVCHDGAEVLDYLYCRGSYRGRQQGNPAVVFLDLKMPKVDGLEVLRTIKNDADLKPIPVVMLTSSREERDLAESYALGANAYVVKPVEFHQFITAVKELGVFWGVINEPPPPGLESRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3J6</accession>
    <name>A0A1W1I3J6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47459">
        <property type="protein sequence ID" value="SLM47459"/>
        <property type="gene ID" value="NSJP_1287"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1287"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045468">
        <property type="entry name" value="DUF6496"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20106">
        <property type="entry name" value="DUF6496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="59" mass="6491" checksum="1AE9B723E0CAAFCD" modified="2017-06-07" version="1">MARYGKSAQKSVKRAMHQKKRGQLKSGKSGKRVTSRKQAVAIGLSEARRKGAKVPRPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3N6</accession>
    <name>A0A1W1I3N6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1432"/>
    <dbReference type="EnsemblBacteria" id="SLM47604">
        <property type="protein sequence ID" value="SLM47604"/>
        <property type="gene ID" value="NSJP_1432"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1432"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014162">
        <property type="entry name" value="CpoB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02795">
        <property type="entry name" value="tol_pal_ybgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012258265" evidence="3">
        <location>
            <begin position="29"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="168" mass="19169" checksum="04B0F4A5F030FFB6" modified="2017-06-07" version="1">MTLSYRPRIVAVFGILLPLCLNPVLASAAPGQVQDTSRHLYDRVMEEFKHRDYEAALAGFRLFLELHAQTALAANAQYWVGECQYRMGRYKDALASFYNVVSYYPLSPKLPASTLKIGQTYTKLKDHEKARMMYERVLDEYPDSPEAEAARKALDMEQPRAESTTLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3U5</accession>
    <name>A0A1W1I3U5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47678">
        <property type="protein sequence ID" value="SLM47678"/>
        <property type="gene ID" value="NSJP_1506"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1506"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="17"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="137" mass="15214" checksum="25E669FFC83C6F7B" modified="2017-06-07" version="1">MGREQPQMQFITGRSIRLLLVDDHAMTRIAIRGVLANQSDIEILGEADDGVEAIRLAARLQPDVIVMDIYLPRMTGIDAARHIKTRFPRMAIVGLSAYANEQRDTMQAVGASAVVPKEKIVEQLHAAIRLAAQETRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3W4</accession>
    <name>A0A1W1I3W4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47690">
        <property type="protein sequence ID" value="SLM47690"/>
        <property type="gene ID" value="NSJP_1518"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1518"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="104" mass="11680" checksum="626FB96C7AB6C308" modified="2017-06-07" version="1">MSPNVQERTGSLADALCMDPVPAFDLRGEVRRNQTWKANRRPKASELSELPLAKIDRLAIELVQCGPCRTRPIAPPSRQNLTKPRSDFRFTCCVKSAKRLATMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I464</accession>
    <name>A0A1W1I464_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase D</fullName>
            <ecNumber evidence="4">5.4.99.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(13) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">truD</name>
        <name evidence="6" type="ORF">NSJP_1569</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(13) in tRNA = pseudouridine(13) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42540"/>
            <dbReference type="Rhea" id="RHEA-COMP:10105"/>
            <dbReference type="Rhea" id="RHEA-COMP:10106"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.27" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1569"/>
    <dbReference type="EnsemblBacteria" id="SLM47741">
        <property type="protein sequence ID" value="SLM47741"/>
        <property type="gene ID" value="NSJP_1569"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1569"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01082">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043165">
        <property type="entry name" value="TruD_insert_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="5">
        <location>
            <begin position="154"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="342" mass="38199" checksum="D27EC381ED5E9297" modified="2017-06-07" version="1">MSHPYLTAALPGIGGRIRVVPEDFQVEEMPLYLPCGEGEHLYIKVAKRLLSTPDLIRRLSSVLGVKVQGIGSAGLKDARAVTTQMLSLHGVTAERAAGIKIDEQVLSVEILGRHRNRLRPGHHAGNRFRLVIRDLEDHAHRTVPLVLQILQERGVPNYFGPQRQGRRGDNYQVGAELLADEARRRKMSRAKRMWYLNSLQSHLFNQILARRVDRLDRVFAGDWAMKTENGACFPVENAEQEQPRADRFEISPTGILFGSRVSWADGEPGIIEREVVSENGATPEGLTEAAKACGFRGERRPLRAKLDQVEWALDGNVLTLGFPLPPGAYATNVLRELMKTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4D0</accession>
    <name>A0A1W1I4D0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47729">
        <property type="protein sequence ID" value="SLM47729"/>
        <property type="gene ID" value="NSJP_1557"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1557"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="58" mass="6127" checksum="3B5A31F5A6223F21" modified="2017-06-07" version="1">MLHATCETHERDGGLSVLLVTTYEPSREKVAFQGNTASPGQVGQGELLGLSGSAKIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4N8</accession>
    <name>A0A1W1I4N8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47987">
        <property type="protein sequence ID" value="SLM47987"/>
        <property type="gene ID" value="NSJP_1815"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1815"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="121" mass="13200" checksum="B70DAEE51025F12B" modified="2017-06-07" version="1">MLDAIVVAAALYVCPGDVYTDTPRAGCQPLQESNREGFSTIPESPEFNSKGSAPGENVKPMRDTQSRIPAASAEECAMYEEWVKLSTKSSSLGARDLSPSEFERWTNLKQVFGNSPPPNCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Q7</accession>
    <name>A0A1W1I4Q7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Type IV pilus assembly protein TapC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">tapC</name>
        <name evidence="11" type="ORF">NSJP_1749</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1749"/>
    <dbReference type="EnsemblBacteria" id="SLM47921">
        <property type="protein sequence ID" value="SLM47921"/>
        <property type="gene ID" value="NSJP_1749"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1749"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001992">
        <property type="entry name" value="T2SS_GspF/T4SS_PilC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00874">
        <property type="entry name" value="T2SP_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="10">
        <location>
            <begin position="67"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="10">
        <location>
            <begin position="273"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM47921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="404" mass="43379" checksum="F137D084B8254C0A" modified="2017-06-07" version="1">MATFAYVGRSRSGAVRKGELSAKNRDEAVDQLRKQSIVVTSLDEKAGKSGFNLSFGNGLTDKDLVVFTRQFGTMINAGLPLVQCLEILSTQSENKALRESVGEVKVQVEAGSTFSDALRRHPKVFDDLYVNMVHAGEVGGLLDTILTRLAKHIEKAMKLKGQIKSAMVYPAAILGVAGVVITVLMIWVIPIFAKMFDELSSGKVGLPGPTQLVIDISNAFQSYWYVAAGLVAGLIFGVKKYYATPKGRMAIDKFLLKTPVFGDLIRKASVAKFTRTLGTLLSSGVPLLDGLIICAKTSGNKVIEEALLNARVSISGGKTIADPLTQSQVFPKMVTHMIAVGESTGALDAMLGKIADFYEDEVDQAVASLTSLLEPMMMVFLGVVIGFIVIAMYLPIFKMASAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4R4</accession>
    <name>A0A1W1I4R4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47879">
        <property type="protein sequence ID" value="SLM47879"/>
        <property type="gene ID" value="NSJP_1707"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1707"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="20"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="130" mass="14753" checksum="DFA601E4389D3A6E" modified="2017-06-07" version="1">MRCTKVRSNRSLRLQTTPCNRREHLRVPANFSLMYSAQPEGRHVLVGDGTVTSLSRHGLGVRGNTPVRTGMELTLFLYLPDGQDPLFVTAAKVTWTAGHRFGVMITGMNLREQNRFRYFVAGSLHEKRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4U6</accession>
    <name>A0A1W1I4U6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48038">
        <property type="protein sequence ID" value="SLM48038"/>
        <property type="gene ID" value="NSJP_1866"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1866"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="35" mass="3778" checksum="675B7F17FE11A84B" modified="2017-06-07" version="1">MTQAVIDAMVYWSAAFFLGGFTVGVIVKLLLGETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4W9</accession>
    <name>A0A1W1I4W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_1882</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1882"/>
    <dbReference type="EnsemblBacteria" id="SLM48054">
        <property type="protein sequence ID" value="SLM48054"/>
        <property type="gene ID" value="NSJP_1882"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1882"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="66"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="316"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="752" mass="82785" checksum="4EBF7F9ED4DBA9FC" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I502</accession>
    <name>A0A1W1I502_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13 14">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="5 13 14">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">murD</name>
        <name evidence="17" type="ORF">NSJP_1731</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="5 13 14"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1731"/>
    <dbReference type="EnsemblBacteria" id="SLM47903">
        <property type="protein sequence ID" value="SLM47903"/>
        <property type="gene ID" value="NSJP_1731"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1731"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 13 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 13 14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="12 13 14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13 14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="16">
        <location>
            <begin position="119"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="15">
        <location>
            <begin position="334"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="121"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SLM47903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="469" mass="50558" checksum="79A17A027D7B7B13" modified="2017-06-07" version="1">MVGADQTSLAGARVTVMGLARSGVAACRLLQEVGARVTVSDRKEPGELQSALGDIDLGAVQVTVGPSYESSLEGADLVVISPGVPYRMEALERVRRRGVGVISELELASRFLAAPMLAVTGTNGKSTTVTLIGKILAEQGKRVFVGGNLGTALSDAAWAAVKAKKEGRADPFDYLVVEVSSFQLETVDRFHPWIAGILNVTVDHQDRYDSLDDYLEAKARIFENQSPEDYALLNLDDPRVSRLGGRIRSRRIGFTRAGTLGLGADQGTFLDGDTIVTTVTGSRQTICRTREIRMLGSHNVENVMAASTYAALCGCSPDVIRKTVTAFPGLEHALEFVRERRGVRFVNDSKGTNVDATLKALEGIDHPIWLIAGGRDKGGDFSRLTDAVRRRVTHAILIGEAAPVLRQAWHGAVKMSEAGSLREAVQYAARESSAGDVVLLSPACASFDMFRDYQDRGRQFKEVVLSLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I505</accession>
    <name>A0A1W1I505_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48094">
        <property type="protein sequence ID" value="SLM48094"/>
        <property type="gene ID" value="NSJP_1922"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1922"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010620">
        <property type="entry name" value="SBBP_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06739">
        <property type="entry name" value="SBBP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012167338" evidence="1">
        <location>
            <begin position="31"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="918" mass="94775" checksum="9C727548B0AB4A5E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I576</accession>
    <name>A0A1W1I576_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48150">
        <property type="protein sequence ID" value="SLM48150"/>
        <property type="gene ID" value="NSJP_1978"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1978"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="254" mass="29529" checksum="4F366E87A5F8D305" modified="2017-06-07" version="1">MIRGYDRPHAVRTARMCAAVAGALGHDPDRVRQYQIACLLHDLGRAGLDRRLFGKIWSWAKAHGIPTRPREWRTIHPETVYGRETEAFLSRYRQELKADGIDMTPWAVEQVEMRLGYARRLARRLRAVRSGIKKLGIRWEPWMQAVMLYYYYPEKLAGAEPWVKQLAEVLVACEQFEAYSNQRRGRDYYLRQKETIPEAFAYLGTLERDGMVSADVMDALTRLAADGTFDDVLAEARGRRLTPMDRKALRRLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5A4</accession>
    <name>A0A1W1I5A4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2026"/>
    <dbReference type="EnsemblBacteria" id="SLM48198">
        <property type="protein sequence ID" value="SLM48198"/>
        <property type="gene ID" value="NSJP_2026"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2026"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="154" mass="16336" checksum="7831ED01AE1A5733" modified="2017-06-07" version="1">MAAESGEVHLFGFSTGMYPKAQVLNRFIAKLIDLFIVAGAASLIDPVGFLGGLAYVLVGDGFAGGRSIGKRLIGLQTILPDTRVTAGFRESIIRNVPFAVAQMAFIVPYVGWILSAVIIAFEAVLIIGNEQGRRIGDELAGTQVLDVGRFALPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5C1</accession>
    <name>A0A1W1I5C1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
            <ecNumber evidence="5">2.4.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">queA</name>
        <name evidence="6" type="ORF">NSJP_2024</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:32155"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="2.4.99.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the QueA family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.17" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2024"/>
    <dbReference type="EnsemblBacteria" id="SLM48196">
        <property type="protein sequence ID" value="SLM48196"/>
        <property type="gene ID" value="NSJP_2024"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2024"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00113">
        <property type="entry name" value="QueA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00113">
        <property type="entry name" value="queA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="344" mass="38143" checksum="2F35272CF4A84D31" modified="2017-06-07" version="1">MQVAEFDFPFDPRLVASEPVLPRDQAKLLVLPASHRSSHSMMHHRVADLPHLLAPGDLIVVNDTKVMPVRLTGRKQPTGNAVDILFVREVAEGLWEVLIKGRLRPGQRIDLGVDGVLEVQSRDRVRTVVRLDCAMSPREFFARWGMMPLPPYIDRAPGDMDREWYQTVFAQEEGAIAAPTAGLHFTPELLTRLNQAGIGVARVTLHVGIGTFKPITTDHVEDHRMGSEWFEVGAETVQAIAHTKEKGGRIVAVGTTVVRALETAAARQGALGPQRGETSLFITPGFSFQVVDALMTNFHLPKTTLLMLVSAFAGTSLLRQAYEEAVRERYRFYSYGDAMLILKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5D6</accession>
    <name>A0A1W1I5D6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48099">
        <property type="protein sequence ID" value="SLM48099"/>
        <property type="gene ID" value="NSJP_1927"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1927"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012732224" evidence="1">
        <location>
            <begin position="26"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="199" mass="21827" checksum="6CF8C462EF3E620F" modified="2017-06-07" version="1">MNLSRASNLGTLSLALILLVSIARAPVAASGAEEMVPLQQEEGSCPDLTGLYEYQGKAADGFPTYYRALKTPLTLDRLLGTFAFGNKYPELIGGQLSGIGRGLELTILGTNAFTYLDSVVRPEDRVVCEAEMLRLEQHREVGGDGAYNKLHIIRTASIEKGGALQVNVTIRGSGRFLFFFWYELPSEEYQAVFLRKAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5E5</accession>
    <name>A0A1W1I5E5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1979"/>
    <dbReference type="EnsemblBacteria" id="SLM48151">
        <property type="protein sequence ID" value="SLM48151"/>
        <property type="gene ID" value="NSJP_1979"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1979"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="143" mass="15516" checksum="6477FA41409DB95B" modified="2017-06-07" version="1">MAVKTVPLRLSMRGGTQIENVTESVQEALADSKLAAGIATVFVRHTTASVMIIEDEPGIRADTHAFWDRAVPADPAWQHNVRNAGEDNGHSHLRGQLQGPSVTIPFAAGALLLGTWQQIVVVDFDTRARTREIVIQLIGEPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Y1</accession>
    <name>A0A1W1I5Y1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Nitrate oxidoreductase, beta subunit</fullName>
            <ecNumber evidence="4">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nxrB</name>
        <name evidence="2" type="ORF">NSJP_0816</name>
        <name evidence="3" type="ORF">NSJP_0950</name>
        <name evidence="4" type="ORF">NSJP_2213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.7.99.4" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0816"/>
    <dbReference type="EnsemblBacteria" id="SLM46988">
        <property type="protein sequence ID" value="SLM46988"/>
        <property type="gene ID" value="NSJP_0816"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47122">
        <property type="protein sequence ID" value="SLM47122"/>
        <property type="gene ID" value="NSJP_0950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48385">
        <property type="protein sequence ID" value="SLM48385"/>
        <property type="gene ID" value="NSJP_2213"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0816"/>
    <dbReference type="KEGG" id="nja:NSJP_0950"/>
    <dbReference type="KEGG" id="nja:NSJP_2213"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="429" mass="49897" checksum="A1F22157571D5543" modified="2017-06-07" version="1">MPEVYNWQLGRKMLYPYEERHPKWQFAFVFNINRCLACQTCSMADKSTWLFSKGQEYMWWNNVETKPYGGYPQFYDVKITQLIEQVNPGGQVWNVRVGRKHHAPYGVFEGMTIFDAGAKVGQAAIGYIPTDQEWRFVNIYEDTATSMRSLVEGIDRSGFSRDEPWRLSGSSLPEHETFFFYLQRICNHCTYPGCLAACPRKAIYKRPEDGIVLIDQNRCRGYKKCVEQCPFKKPMYRGTTRVSEKCIACYPRIEGKDPLTGGEPMETRCMAACVGKIRMQSLVRIGEDGLWAEDRWHPLYYTIRVEQVALPLYPQWGTEPNGYYIPPRHSPRGYARQMFGPGVDNAIEKYLVPSRELLAVLQLWRASQQIVFRYDVIPGPKVFETQIHGKRFEMYNDTVLGFNKSGKEVARIQVEEPIYIRPAERVNWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I685</accession>
    <name>A0A1W1I685_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rplE</name>
        <name evidence="9" type="ORF">NSJP_2350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2350"/>
    <dbReference type="EnsemblBacteria" id="SLM48522">
        <property type="protein sequence ID" value="SLM48522"/>
        <property type="gene ID" value="NSJP_2350"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2350"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="64"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="124"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="219" mass="24414" checksum="B195AC9332E072A4" modified="2017-06-07" version="1">MADAKDPKKSKGAKPAGRASKKDGAPAPQALDDGSEESKFKPRLRDMYREQVIPALMKEFGYKNLMQVPKLERIVLNVGMSEATQNVKLLESAATELGMITGQKPVITKAKKAIAGFKLRQGMPIGTKVTLRNRRMYEFFDRLVTLALPRIRDFRGVSPKAFDGRGNYTLGLKEQLIFPEIKYDEVASIHGMDITIVTTARTNDEGKALLRQLGMPFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6E5</accession>
    <name>A0A1W1I6E5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative Ferric iron uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_2426</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2426"/>
    <dbReference type="EnsemblBacteria" id="SLM48598">
        <property type="protein sequence ID" value="SLM48598"/>
        <property type="gene ID" value="NSJP_2426"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2426"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030148">
        <property type="entry name" value="Fiu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF68">
        <property type="entry name" value="PTHR32552:SF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0798">TonB box</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013117005" evidence="9">
        <location>
            <begin position="36"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="STN" evidence="10">
        <location>
            <begin position="64"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="832" mass="90649" checksum="DEC73130ADD5A834" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Q7</accession>
    <name>A0A1W1I6Q7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rplB</name>
        <name evidence="7" type="ORF">NSJP_2341</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2341"/>
    <dbReference type="EnsemblBacteria" id="SLM48513">
        <property type="protein sequence ID" value="SLM48513"/>
        <property type="gene ID" value="NSJP_2341"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2341"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="6">
        <location>
            <begin position="124"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="280" mass="30549" checksum="C6E19C883FDDBFB1" modified="2017-06-07" version="1">MGLKAYKPTTSGRRGMSVVTTDELTGKRPEKSLTSFHHRSGGRNNDGRTTVRFRGAGHRRLYRKIDFRRDKVGITAKVAALEYDPNRSARIALLNYRDGEKRYILAPVGLQVGDVLQSGADAEVRTGNALPLANMPLGTTIHNIELKPGKGGQLIRSAGGFAQVMGRDGDYVQVRLKSGEMRRVLASCMATVGQVGNLDHENINVGKAGRSRWMGRRPHVRGVVMNPVDHPHGGGEGKSGQGNPHPVSPWGLPTKGYKTRNNKATDKYIIARRKSGVRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6R1</accession>
    <name>A0A1W1I6R1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Type IV pili biogenesis protein PilQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_2377</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial secretin family. PilQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2377"/>
    <dbReference type="EnsemblBacteria" id="SLM48549">
        <property type="protein sequence ID" value="SLM48549"/>
        <property type="gene ID" value="NSJP_2377"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2377"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021731">
        <property type="entry name" value="AMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005644">
        <property type="entry name" value="NolW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038591">
        <property type="entry name" value="NolW-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013355">
        <property type="entry name" value="Pilus_4_PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004845">
        <property type="entry name" value="T2SS_GspD_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11741">
        <property type="entry name" value="AMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03958">
        <property type="entry name" value="Secretin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07660">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02515">
        <property type="entry name" value="IV_pilus_PilQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00875">
        <property type="entry name" value="T2SP_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="STN" evidence="7">
        <location>
            <begin position="271"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="655" mass="70935" checksum="554C6FF129CBDDC2" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6V3</accession>
    <name>A0A1W1I6V3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Ribosomal protein S30Ae-family protein, sigma-54 modulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2371"/>
    <dbReference type="EnsemblBacteria" id="SLM48543">
        <property type="protein sequence ID" value="SLM48543"/>
        <property type="gene ID" value="NSJP_2371"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2371"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="168" mass="19251" checksum="A0BF43CB9EC03E69" modified="2017-06-07" version="1">MKITGRHLVITPALKRHIREKFERLDRYGVLLDRMQITLGVNKLQHTAEALCSVNRKQFQAKTSTREMYMTIDQLVDRLETQIRKYKERRTEHKGKKSAARRVPFVPPDSVEQDIEVVRPKVSVLSRAAASSRLDDLPGSIMVFTCAESGKLQILRRAESGKIVLIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6W2</accession>
    <name>A0A1W1I6W2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48756">
        <property type="protein sequence ID" value="SLM48756"/>
        <property type="gene ID" value="NSJP_2589"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2589"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="430" mass="48675" checksum="D8DE34B71DCCEB4C" modified="2017-06-07" version="1">MGHLLPLHVGDSRLGRMCLFLLIGVVVFLIESLSHATAATEYETPEPRTIEDALPPELRDVPHGRIEAPVQHDGYMHGYTVDTDFGVYLAHGDTMFRRLRLELTAIADLRARFAPKVAVESAVKVVVRPIHAVGRLASEPLDTLAGMPRGVYRLIESSVTGMFRDSSQYEDSDFKNLVQVAAYKRRIAAHYDVDVYSSNPILQLELDRVAWASLAGYTTTFAMLLVPVPNPLPLAVVSLNSVEVLNRVLEERGPDDLRLLNRRQLRAMGIKEELIEKFLDQPYYSPRHQTIIVACLGTLTETKRRDRFLTVALNALSEEEAFFYQQAAELLQAYNREESSITEITIFGRVPLGRTKDRSAIFPAPVDYAIWTDKTEAVVNRLVSAVRHRKRSARVEMWIAGSLSPRVRQELRERKIVTKEQMQNKMQLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Y5</accession>
    <name>A0A1W1I6Y5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytoene synthase</fullName>
            <ecNumber evidence="2">2.5.1.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">crtB</name>
        <name evidence="2" type="ORF">NSJP_2631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.32" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2631"/>
    <dbReference type="EnsemblBacteria" id="SLM48798">
        <property type="protein sequence ID" value="SLM48798"/>
        <property type="gene ID" value="NSJP_2631"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2631"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016767">
        <property type="term" value="F:geranylgeranyl-diphosphate geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017828">
        <property type="entry name" value="SQ_synth_HpnD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03465">
        <property type="entry name" value="HpnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="288" mass="32643" checksum="F54D3E9A1E58D9B4" modified="2017-06-07" version="1">MTMTVKDAQAYCTELTKKSGSNFYYSFLFLPKARRNAMYTIYAFCKGVDSAVDEPPAGSDPKEELRRWRSELDAAYEGTPIWPLMISLAHHVRELSIPKAYFEELIKGVEMDLSASRYATFDELSLYCYRVASVVGLICLHVFGPTSPHAQDYAVDLGMAFQLTNILRDLGTDAEQGRIYLPQEDLARFGLTESDILERKPAQKLRDLVDFEVGRARAYYAKARASLDSLPSSDRRALTVAEIMRAVYSEILLRIERADHVVFGPRVKLTTSERLRLAAGVWLRSRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I710</accession>
    <name>A0A1W1I710_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48784">
        <property type="protein sequence ID" value="SLM48784"/>
        <property type="gene ID" value="NSJP_2617"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2617"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="14"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="120" mass="13658" checksum="B9360B759AE794D8" modified="2017-06-07" version="1">MINQIESIDPVKELRRTPRLRIPVPFACSFSRLGLSRWRFGDRGGHGVVFDLSVKGARVMSPLLVKEGDELAISIRLPNHPTTMSLDATVRWQQEHMFGLEFGTIPQGSETRLRKYLARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I733</accession>
    <name>A0A1W1I733_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48848">
        <property type="protein sequence ID" value="SLM48848"/>
        <property type="gene ID" value="NSJP_2681"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2681"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="276" mass="30637" checksum="8BA209770E19A29D" modified="2017-06-07" version="1">MAEIVTATVNLYRQALRKTWQSLVRGWIIMVALIGFMLILAVTTQLAGPLGIAGGFLLGAVNALLVGAVLSLIEQSISYGRTLTLRDVFDSFGRYFWDVIGVGFVLWLPLLALEMGTQTNPYGPFLSYAVLVLLFLLLNPAPEVIYQVHHDSPLDVMKTSYEFVLENWMEWFLPIAVLLIPIVLSPAGVREVFSLSSRAGRGAGLDFFQLLVLPFTILGGWLGYLGIPSAMSWYLLLLLTPPMAVAMLLFRGHLFALLSGSSRRQRRFASQHYRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I747</accession>
    <name>A0A1W1I747_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2638"/>
    <dbReference type="EnsemblBacteria" id="SLM48805">
        <property type="protein sequence ID" value="SLM48805"/>
        <property type="gene ID" value="NSJP_2638"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2638"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001893">
        <property type="entry name" value="Cys-rich_GLG1_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00839">
        <property type="entry name" value="Cys_rich_FGFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="208" mass="22497" checksum="6D9F5BC79EEBCFFF" modified="2017-06-07" version="1">MAQLDAWSRIAAGAVTVVGLTAVWLAVVTSLPTQEELAGNALRPVRVATAASPVRAEPSLDLSIPGVVSSVPSAAQPAAPAPSEPSGEFRRGAPMVDARAAQITRLKCEAEIEQICPEGMDGGGFRCVERRMKDLPPSCQGMVRERFVKWKEDRNRTLVACRDDVRRLCATMRPGDGRVMQCLQDHAQDVSDGCYQTLPKGVLLFRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I753</accession>
    <name>A0A1W1I753_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48837">
        <property type="protein sequence ID" value="SLM48837"/>
        <property type="gene ID" value="NSJP_2670"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2670"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="179" mass="20125" checksum="75AFEA1C7D20F786" modified="2017-06-07" version="1">MPIECPRCLLNNPDTTYICECGYDLVSQMHRGPRSEGGIRGGSEYGMSKEGFLLGVFIVWFLLIFGEWSRIRPELKTRKTFNLLTDSMMLSLTDMAGALIIGALGWAVVWVILAYEGRRLRPCPRRTTLGVTVVAAGLLYLTRWIAPDIHMQHIVQAVVVLGVAVFAYYAGTRQWLGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I764</accession>
    <name>A0A1W1I764_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48834">
        <property type="protein sequence ID" value="SLM48834"/>
        <property type="gene ID" value="NSJP_2667"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2667"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="151" mass="16351" checksum="CE2616C38F9F9720" modified="2017-06-07" version="1">MEPKYRTHVLMVVFSVLALVGMIACSKQKPKPLVPLTLETGAPAQAVSLTEQGIQAYHGRQFEEAKGYFTQAVAAAPQSGPAHYNYALALYSLGDAEEARKHFMEAANLAPGDKVIWDSPALHQFGNPESPKAMKEHQTTTSRPTFGGGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7F8</accession>
    <name>A0A1W1I7F8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type transport system periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2632"/>
    <dbReference type="EnsemblBacteria" id="SLM48799">
        <property type="protein sequence ID" value="SLM48799"/>
        <property type="gene ID" value="NSJP_2632"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2632"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="311" mass="33385" checksum="944D3C5EEE6E8E03" modified="2017-06-07" version="1">MRICSLVPGATEVVAALGQASRLVGISHECDFPLSVRHAPVLVEPCIEATTTDSAAIDREVRALVSSGRPLYRLNERAFATSKPDVILTQDLCHVCAITPDQLTRAVAALPIHPTWLTLNPTTLADVISDVERIGAAIDRPSEGKVLAASLRTRLASVQHGHRSKRPRVACLEWLSPLYAGGHWVPEMVELAGGSDALGLAHHPSRPVTWEQVESARPDIVILMPCGFSVDRAWRELAALQHTDRRWSSAIASWPLTFVVDAASYFSRPGPRLVDGVELLASIFATGSAGKLDDTAARAVPCSSPLLASPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7K4</accession>
    <name>A0A1W1I7K4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49002">
        <property type="protein sequence ID" value="SLM49002"/>
        <property type="gene ID" value="NSJP_2835"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2835"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012867954" evidence="1">
        <location>
            <begin position="26"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="111" mass="12168" checksum="0D3E6EB8EEAFBF09" modified="2017-06-07" version="1">MVSPFRHNRRFIGLLAVTLMLLTCAACSDAVQLVGETETGGVVTYLYKEDRGGPMGSPHRKEALAVIEKKCPSGYMVVRDGEVRGYSGMSSTDGHEGEVTGQRWGIRFRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I808</accession>
    <name>A0A1W1I808_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">grpE</name>
        <name evidence="7" type="ORF">NSJP_2969</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2969"/>
    <dbReference type="EnsemblBacteria" id="SLM49136">
        <property type="protein sequence ID" value="SLM49136"/>
        <property type="gene ID" value="NSJP_2969"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2969"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0346">Stress response</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="191" mass="21272" checksum="843BFA2F2202BB01" modified="2017-06-07" version="1">MSEKDKKINIIDNLDEEPVVDFSEESGEALESVLQKALAAKSEELKALNDKYLRQAAEFDNYKRLAQRDQREQIKFGNEQLLKELLPTVDNLERAIKAAKTDKSNESLIQGVDLTLKQVLTVLGRFGVQAIDTVGKPFDPSAHQAVASVPSDTVPPEHVVEEFQRGYRLHDRILRAAMVTVSTGRAADDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I809</accession>
    <name>A0A1W1I809_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49162">
        <property type="protein sequence ID" value="SLM49162"/>
        <property type="gene ID" value="NSJP_2995"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2995"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="81" mass="9159" checksum="EDA0436BB42D99E5" modified="2017-06-07" version="1">MMPGRSRVIQHLGPVSAGKLSSVDCTVSSEAYSNKEFREVQKVKETRSENPEGEKRGKGEKFYDGFNCIRRRTSFASSGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I850</accession>
    <name>A0A1W1I850_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49202">
        <property type="protein sequence ID" value="SLM49202"/>
        <property type="gene ID" value="NSJP_3035"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3035"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="401" mass="42456" checksum="CACC9F138186835D" modified="2017-06-07" version="1">MSEKSRHCGGFASIYTVLIFSVLVCSPSPATGTDLPIQGGPGGTLFRAECPKGAYLTGLAGRAGKWIDQLAPICSPLETVKRTFGAPQTMGSHGSSSGGSPRTASCALGGAIAGLDFDNTIGEGGLPDHKFVSRLYAYCQGIIPNTLNSFFIFSPGGEGGGQFVPYGSDSFCPTGLVAVGFHGRAGLFVDALGLICQPLIKPGTAQTDIQKMTQAFPNAPAILSPKPNGFIIKGNGVFRIAPSQFLSGTDAEIELKWLNPSANLRQQNVQTVYTYRAPMSVIAGPKGVDAPQIYLAPGTWEIRVRIVVPKAGDWSAPVRFTYYLQHPSFGTPTQDAQNQDLQFGIGGQQKNMNQATGVYRPQSTPQQGMGNTSVIRPRGVDDGETKEDRPSAEPAETEKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I863</accession>
    <name>A0A1W1I863_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49186">
        <property type="protein sequence ID" value="SLM49186"/>
        <property type="gene ID" value="NSJP_3019"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3019"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="154" mass="16251" checksum="41840EF1FAD81017" modified="2017-06-07" version="1">MKHHRLILSVATGLLVLGIVLPSGVFAKPKKSTPESCTTKDLNTNFGASCNDQMQQDLMGNKPYTHVLFCGGDTMLCCTVDNSTNQVINCRKPAGTRVMPGMSGNAMSQAGMAGVQRRGVEETSKAEDTAGEPTPVPDWVKELAAQGEGGGKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8N8</accession>
    <name>A0A1W1I8N8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49360">
        <property type="protein sequence ID" value="SLM49360"/>
        <property type="gene ID" value="NSJP_3193"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3193"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="61" mass="7178" checksum="5ACB93C990017424" modified="2017-06-07" version="1">MWWSWPLLRLGISKLNLGYLCCYARLRGLTVSKTFHFPQKGHRISQCPFSYFTPERGRIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8R5</accession>
    <name>A0A1W1I8R5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DSBA oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3240"/>
    <dbReference type="EnsemblBacteria" id="SLM49407">
        <property type="protein sequence ID" value="SLM49407"/>
        <property type="gene ID" value="NSJP_3240"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3240"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="180" mass="20488" checksum="C9E83200FAE4D0E1" modified="2017-06-07" version="1">MAEPHHHGQSLDLTEHDHVQGEVSAPVVLIEYGDFQCPFSREAVKTVRALQREFDRSLRFVFRHFPLVDKHSHALQAAEAAEAAAAQGQFWAMYTMLFANQWELEYGDLMEYAKQLELDRTQFSESLTTHRHLDRIRTDVGTGRRHGVTGTPTFFINGRRQDGNDDLRALAAAMRHALGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8R8</accession>
    <name>A0A1W1I8R8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49385">
        <property type="protein sequence ID" value="SLM49385"/>
        <property type="gene ID" value="NSJP_3218"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3218"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012415919" evidence="1">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="105" mass="11113" checksum="E22ECC0F17CDA039" modified="2017-06-07" version="1">MAGGWKGWAVASAIVLCFTMTGCAKTGPEKHTAVPSKGERVMNDAVTGQISEMGSDHVSITQAGGKIRHVRVDSHTKMDQMAKGDYVKAFVSDDGYASTIQRVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8S0</accession>
    <name>A0A1W1I8S0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49404">
        <property type="protein sequence ID" value="SLM49404"/>
        <property type="gene ID" value="NSJP_3237"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3237"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="131" mass="14401" checksum="BA748D80E71A5A55" modified="2017-06-07" version="1">MRHAPWVSISLPVLIAFATYSWAGVALKLHSVLAHPESYQSSVIQVTGVVSNHQFQRVKKWMANVDKCVQTFTVTDGADSIQAVYGANCAGALDLLRNRDRVTLQARFDWKPGKAGMLTVQSVVSKVTPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8T6</accession>
    <name>A0A1W1I8T6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49458">
        <property type="protein sequence ID" value="SLM49458"/>
        <property type="gene ID" value="NSJP_3291"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3291"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="62" mass="6783" checksum="3C950EB1BE86D453" modified="2017-06-07" version="1">MFYETSKRMQLQINEDLDKICTAGQASSMVRCAAGRKGLSGLMRGFTSSGLFSDDANSERTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8W9</accession>
    <name>A0A1W1I8W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49371">
        <property type="protein sequence ID" value="SLM49371"/>
        <property type="gene ID" value="NSJP_3204"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3204"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012890391" evidence="1">
        <location>
            <begin position="21"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="105" mass="11793" checksum="DB4B20F6FA7896D9" modified="2017-06-07" version="1">MTTLRLFCLLAGCLLLQGCAEGMHGKSDESWNSWIGSTKDDRVRDQGIPTRCHTFKTGGEACEWPIIWAPNSSGTITISFDEKGTACQWVYKDSYIEKRSDKRCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I903</accession>
    <name>A0A1W1I903_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49494">
        <property type="protein sequence ID" value="SLM49494"/>
        <property type="gene ID" value="NSJP_3327"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3327"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="293" mass="33064" checksum="BF756534722785D9" modified="2017-06-07" version="1">MRLDFLSYAAANLFVSHPRLATLKRLGTATGFTAFLILILTVLHPTLAQADPVAVRFPEGLTHGFLQVHSPAGDLLGRGELTQTVKEVDLVESRLLFVFKDGSRHEERVSFSQKRLFSLVRYRLTQRGPSFPQQLDVTFNRGSAAYEVRSGRWGDEKEELLRGKIEVPKDVYNGMLLTVLMNLPPGASESIKVLTFTPEPKIIKLALRFMDEHTVRIGEQPRKALRYSFEPALGVIEKFFGKVLGTLPDDFHYYCWILADDIPAFVKFEGPLQLLGPIVRIELVSPRLELTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I910</accession>
    <name>A0A1W1I910_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alginate_exp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49507">
        <property type="protein sequence ID" value="SLM49507"/>
        <property type="gene ID" value="NSJP_3340"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3340"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025388">
        <property type="entry name" value="Alginate_export_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13372">
        <property type="entry name" value="Alginate_exp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012754594" description="Alginate_exp domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate_exp" evidence="3">
        <location>
            <begin position="88"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="510" mass="57781" checksum="E1DE257731A1E40F" modified="2017-06-07" version="1">MVLRYLLRFLLLCSTLTVQAAWAEENSPANPPSENSARILESSPSEEESPRFGPLVQRLHDIVMSDGSPVRLPQSQFHLDQALHVPDWLHLSVDFRTRYESYSQPVKKNETTGGAQFSERTDVNMEMRYKPFKFHAEFLDARPLYNYGVIVSGNMENRNDMLQLYGSLWSDNFLGSGQPTELQIGKFTQAFGKSRLIARSFYSNVPYSFVGAHWSWGKATDWQVRAFAMRPVKNQQTSPDTLDSHTNFFGLSYLNQRRPWLHTELYTFTLTQTAEGQGINGRSQEQITTGRRPHLTTMGFRLFQPEAAGAFDYEIESAYQFGQSALQPGGPPLTTFSFFQHGEFGYTFNVRWKPAIRLEYDYASGDKNPNDNQNGRFDPLFGTYGFSFTPTGIWGLFKRSNINSPGYVLSVQPVNNLRASFKQRFWFLAQAKDEFQGADLQDQTGQAGTSLGSDLDTRLAWTAGPNLIVEGGWLYLIKGSYYSNLLSQGVAGSPNDKNASYMFLSVRLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I912</accession>
    <name>A0A1W1I912_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">trpD</name>
        <name evidence="6" type="ORF">NSJP_3202</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3202"/>
    <dbReference type="EnsemblBacteria" id="SLM49369">
        <property type="protein sequence ID" value="SLM49369"/>
        <property type="gene ID" value="NSJP_3202"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3202"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="4">
        <location>
            <begin position="76"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="109"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="337" mass="35165" checksum="6607426D6E1D2FD4" modified="2017-06-07" version="1">MMIREAIEKLADRTSLTEKEAEEVMNEIMDGAATPAQIAGYLMGLRLKGESVEEIAGSVRAMRGHAVRIAVGDPLVVDTCGTGGDGRHTFNVSTTSAFVVAGAGLTVAKHGNRSVSSKSGSADVLAALGVKIDLSTDRVADCVNEIGIGFLFAPLYHGAMKHCAVPRQELGIRTMLNVLGPLTNPAGAGIQVIGVYEPRLTELLGKVLMHLGSQHSFVVHGMDGLDEITLTDRTLISETKGGVLSTYVLSPSEFGLAKVSPKELAGGGPRDNALITKEILQGRKGPKRDMVCLNAAPALVAGHKAKTLADGFALAAKTIDSGAAAEKLARLIAYTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I943</accession>
    <name>A0A1W1I943_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pyruvate dehydrogenase E1 component</fullName>
            <ecNumber evidence="2 8">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">aceE</name>
        <name evidence="13" type="ORF">NSJP_3232</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2 8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3232"/>
    <dbReference type="EnsemblBacteria" id="SLM49399">
        <property type="protein sequence ID" value="SLM49399"/>
        <property type="gene ID" value="NSJP_3232"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3232"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02017">
        <property type="entry name" value="TPP_E1_EcPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035807">
        <property type="entry name" value="PDC_E1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004660">
        <property type="entry name" value="PDH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041621">
        <property type="entry name" value="PDH_E1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF3">
        <property type="entry name" value="PTHR43825:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17831">
        <property type="entry name" value="PDH_E1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000156">
        <property type="entry name" value="Pyruvate_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00759">
        <property type="entry name" value="aceE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="11">
        <location>
            <begin position="85"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="PDH_E1_M" evidence="12">
        <location>
            <begin position="488"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM49399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="899" mass="100890" checksum="D65A2A248E283D96" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9B3</accession>
    <name>A0A1W1I9B3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Biotin carboxylase</fullName>
            <ecNumber evidence="3 9">6.3.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Acetyl-coenzyme A carboxylase biotin carboxylase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">accC</name>
        <name evidence="12" type="ORF">NSJP_3413</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="3 9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3413"/>
    <dbReference type="EnsemblBacteria" id="SLM49580">
        <property type="protein sequence ID" value="SLM49580"/>
        <property type="gene ID" value="NSJP_3413"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3413"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004549">
        <property type="entry name" value="Acetyl_CoA_COase_biotin_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00514">
        <property type="entry name" value="accC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="120"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM49580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="446" mass="48969" checksum="9E5ADB689942165C" modified="2017-06-07" version="1">MFKKVLVANRGEIALRVIRACKELGIKTVAIHSEADASGLHVRAADERVCVGPAEAALSYRNIPNVLSAAEITGADAIHPGYGFLSENAHFAEVCESIGVKFIGPTSENIALMGDKAKAREIVAKRGLPVTPGSPGGLKSEQEAIEAAQKIGYPVIIKAAAGGGGRGMRVVNKADDLGRAFQAAQAEAKSTFGNDSVYLERYFLEPRHIEVQIVADHRGHVVYLGERDCSIQRRHQKLVEETPSPAVDEKLRREIGRTAVEAVKAVHYRNVGTVEFLLDKDQNFFFMEVNTRIQVEHPITEMVTGIDLIKEQIRLADGEPLSFKQQDIKLSGHSLECRINAEDPEKFTPSPGLITRYSAPGGFGVRVDSAMESNALVVPYYDSMIAKVITHGRDRQEAIARMRRALDEFIIEGIKTTIPLHKRILNDPDFQKGHVSTTFLDRFLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9C2</accession>
    <name>A0A1W1I9C2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="7" type="primary">dfp</name>
        <name evidence="3" type="synonym">coaBC</name>
        <name evidence="7" type="ORF">NSJP_3418</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3418"/>
    <dbReference type="EnsemblBacteria" id="SLM49585">
        <property type="protein sequence ID" value="SLM49585"/>
        <property type="gene ID" value="NSJP_3418"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3418"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="13"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="192"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="196"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="415" mass="43888" checksum="C546747F0D69A3B3" modified="2017-06-07" version="1">MVAGQIGPTLAGKHVILGVTGSIASYKAVNLLRALVREGAQVDVAMTRAAAKFVTPLTFEVLSGRPVAADLFEAHQEMKHLTLPERADVIVVAPATANFLAKAAVGLADDVLTTMLLAAACPVIIAPAMDGGMWTHPTVVEHVHTLRRRGVTVLDPEEGPLASGRLGQGRLAEESAILDAIQAVLLPRRDWSGHRVLVSAGPTQEPIDPVRYLSNRSSGKMGYALAEAAQARGASVVLVTGPTALPHPAGVEVVSVETAEEMSKALTMRLSWSTVVIMSAAVADFRPKHRAVNKLKKRDLTNPVLDLEPTGDILADLSARRTGQLLVGFAAETGDLLRHARQKLNAKGVDLIVANDVTTPGAGFGSDHNAATLIDRDGAISELGLRSKRRLADDILDAALRLARTAVRRPMTGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9G3</accession>
    <name>A0A1W1I9G3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3521"/>
    <dbReference type="EnsemblBacteria" id="SLM49688">
        <property type="protein sequence ID" value="SLM49688"/>
        <property type="gene ID" value="NSJP_3521"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3521"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="446" mass="49481" checksum="0E8827AAE8D1EE93" modified="2017-06-07" version="1">MPKVLVADDSIAVRKVAERLLTEAGLGVTLAANGEEALAFLSKECPDLIVSDVIMPDKSGYEVCAFVRAQTSLAGTPVLLISGIVNDEVAKQAESCKADGVLKKPFQGTSLKDRVLELLAKRQAPSSGTPQPAVKPTPSPEADQATRVSQEQLETYRRMAAQLKQAEDDLRKERDQTSRLGEKLAQLDGQLGRLRELEVLAAQDEERQKQARQSSEDARRSEEEAKRLQARLQELESKLAVEHERAAQAEHVANELQLSNGRVSELEARLHAEQEQSAALRRTAEELQGTAKRVHELEAALHEEQNRAEQHTQRIAELQKAAERAREFESALQAERQAATQLVEQMNAMEKALARSQETAQQLAREQQRSEELSQQLHEIGGVVTKAKELEDLLQTERERNAVLTRHVSETEQSAQQATKRFEEMAKKLGEIAGLASQLGNSVRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9I8</accession>
    <name>A0A1W1I9I8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3540"/>
    <dbReference type="EnsemblBacteria" id="SLM49707">
        <property type="protein sequence ID" value="SLM49707"/>
        <property type="gene ID" value="NSJP_3540"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3540"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012668">
        <property type="entry name" value="CHP02466"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13759">
        <property type="entry name" value="2OG-FeII_Oxy_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02466">
        <property type="entry name" value="TIGR02466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="228" mass="25039" checksum="ECA02F74A314B953" modified="2017-06-07" version="1">MGSVVGMSTELEIAIKPLFATPVLVFTVAQHDCLNADLARVILEREASRPAHRDSEVVGWSSPHDLSMLDWAGEMLGKLFDPVLKIAAHMTELSRQSGHGEQRLGWQVAEVWANVQRQGGSNAFHPHPGSFWSGVYYVDTGDIPQEPCGGELRLFDPRGCLPRMLAPYLRYSVPELHDAGTSVSLAPSAGQCLLFPGWLFHAVNVYTGHTPRISIAFNLDPILSKREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9N1</accession>
    <name>A0A1W1I9N1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenosylcobinamide kinase</fullName>
            <ecNumber evidence="8">2.7.1.156</ecNumber>
            <ecNumber evidence="9">2.7.7.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">cobU</name>
        <name evidence="18" type="ORF">NSJP_3535</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CobU/CobP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="8"/>
    <dbReference type="EC" id="2.7.7.62" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3535"/>
    <dbReference type="EnsemblBacteria" id="SLM49702">
        <property type="protein sequence ID" value="SLM49702"/>
        <property type="gene ID" value="NSJP_3535"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3535"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036429">
        <property type="term" value="F:adenosylcobinamide kinase (ATP-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036428">
        <property type="term" value="F:adenosylcobinamide kinase (GTP-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34848">
        <property type="entry name" value="PTHR34848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006135">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="16">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="69"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SLM49702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="190" mass="20839" checksum="03429C036FDA9E81" modified="2017-06-07" version="1">MHKALRYPMRMTVRCKSQLIFVLGGASSGKSEAALRLATKGVRPTVSRAFVATGQALDKEMAERIARHRSSRPASWVTAEVPLDLTGWIERHGREHRVIVVDCLTMWLSNQFGQGRVDAGIVQDMQGVLGAARRTRARIVLVANELGMGIVPGDAVSRRFREVAGTINQLIADESDETHLVVSGLSVRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9S7</accession>
    <name>A0A1W1I9S7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 18" type="primary">hemA</name>
        <name evidence="18" type="ORF">NSJP_3578</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 13">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8 13"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3578"/>
    <dbReference type="EnsemblBacteria" id="SLM49745">
        <property type="protein sequence ID" value="SLM49745"/>
        <property type="gene ID" value="NSJP_3578"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3578"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="17">
        <location>
            <begin position="6"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="16">
        <location>
            <begin position="172"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="15">
        <location>
            <begin position="321"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="115"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="190"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SLM49745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="454" mass="49967" checksum="24A559B1AFCCB79C" modified="2017-06-07" version="1">MHIVVVGLSHKTAPVEIREKLAIPESRLGEALGRLCSYSGVREGMLLCTCNRVEVYAVVDELDVGYGRIQEFLADAHMSLSSEQLTPHLYWQTGDRAIAHLFRVASSLDSMIVGESQILGQIKDAFDAALAHKATGLILNKVVKKAISVAKRVRTETKISEMAVSVSYAAVELAKKIFSDLSDKTVLLVGAGEMAKLAARHFIANGVRNVCVTTRNPQHGIELADRFGGTAILFEQFREDMASADIVLVSTGAAHYLIGAEDVQRAVKQRMNRPMFLIDISVPRNIDPAVRHVDNAFLFDIDDLKLRVERNKGERVQEAEKAERMVVDEVGIIQQWLRSLEVTPTIVALRTRAEDIRRSEVEKAIGRLAHLSPQERELVEGMASSIVNKLIHHTMVTLKTEVASADGAAFVEAARRFFNLTDAELQGVNGSASTLLKEAGEETEPTQRTGRNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA10</accession>
    <name>A0A1W1IA10_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_3721</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49888">
        <property type="protein sequence ID" value="SLM49888"/>
        <property type="gene ID" value="NSJP_3721"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3721"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="309" mass="34631" checksum="A98C66F18D51CB74" modified="2017-06-07" version="1">MTRDELAIDVQDMTKRFGDRTVVDRIGLQVRKGEICGFLGPNGSGKTTFIRMLCGLLRADAGRGTCLGYDVIRGSREIKRQVGYMTQRFSFYEDLSIAENLDFVARMFDIPDRRNAVRLSLERLGLLERQQQLAGELSGGWKQRLALAACLIHRPKLLLLDEPTAGVDPKARREFWEQIHDLAAEGLTCLITTHYMDEAERCHRLAYIAYGKLLTHGTVQEVIDHAGLTTWLVAGPDLHRLATTLRARSGVKQAVAFGNRLHVSGDDDRALSEAIAPFKTADYDWRRIGPGLEDVFIHLMGSSQDNFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA27</accession>
    <name>A0A1W1IA27_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3604"/>
    <dbReference type="EnsemblBacteria" id="SLM49771">
        <property type="protein sequence ID" value="SLM49771"/>
        <property type="gene ID" value="NSJP_3604"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3604"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="PTHR12935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="147" mass="17158" checksum="C9398D81DA3382D2" modified="2017-06-07" version="1">MKFFLYGDNVNPTQLKRRAPEHQFVTLATLPEHTIQFGRWSSQWRCGLANVAPSPGEKVWGAVFEVTEEDIKLLDQFEEDVPQGAFRHVQVTVHDQAGEKMLVTTYAAESIGKFKPKDHYLDWVLKGLKHWKFPDECIEQWQLYRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA37</accession>
    <name>A0A1W1IA37_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3685"/>
    <dbReference type="EnsemblBacteria" id="SLM49852">
        <property type="protein sequence ID" value="SLM49852"/>
        <property type="gene ID" value="NSJP_3685"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3685"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="133" mass="14637" checksum="0521ABB874504914" modified="2017-06-07" version="1">MTSVMKTTVLVVDDGIDSWNLLSTMLRTHQYYPVWAADGMQATNAALRHEPQAILLDLGLPAGDGFCVLERLKHNTRLSRIPVIVVTGRDPREAEEKARSLGADGYVQKPVKEDELITSLQQVLANRAGTPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA62</accession>
    <name>A0A1W1IA62_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3634"/>
    <dbReference type="EnsemblBacteria" id="SLM49801">
        <property type="protein sequence ID" value="SLM49801"/>
        <property type="gene ID" value="NSJP_3634"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3634"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025411">
        <property type="entry name" value="DUF4136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13590">
        <property type="entry name" value="DUF4136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010748162" evidence="1">
        <location>
            <begin position="19"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4136" evidence="2">
        <location>
            <begin position="21"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="179" mass="19672" checksum="C415FE5DE74F23F7" modified="2017-06-07" version="1">MRILIVCVWLLAAAGCTGPNVQTTSDPTADFTAFRTFAFTGLTDTDQGGLLNNAILRKQIEGVVAEQMTAKGLHRVGLDARPDLLVHLWVGVKEKQQIESTGPYGPRYGWRAGYYGGGVTTYDYEEGTLVVDLAESSKNELVWRARIVSTLESESEENMQLVKDGVAEAFTKYPPAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA76</accession>
    <name>A0A1W1IA76_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltranfer_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3728"/>
    <dbReference type="EnsemblBacteria" id="SLM49895">
        <property type="protein sequence ID" value="SLM49895"/>
        <property type="gene ID" value="NSJP_3728"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3728"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="2">
        <location>
            <begin position="96"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="391" mass="44124" checksum="D1875943A43968A6" modified="2017-06-07" version="1">MIGDSLQRALNAHLEFWKLRRFDSDEAYFHWQRQTLSADDLSILHRQIEQKRQGTGAAEIAFYDATAEPRILPVLYSQRYEYYLTVGALTAERIGRAASVLDFGCGPGILTTFYARRFPHVSFLGVDRSTTSVRRAEEQAATLGLRNVRFECLDIVERRPSVTVDLVVATHALVQAEQDPGLPSLDWRTFERDRDAAVQREFEERTGIGPRLDGLCSLLAADGRMVALEKTRQLSRRVPFQRALAARGLVQTEPSRPVRYNLVEEVAEDGPFYTMRKNGDATVEWNETPEPDEGSPFSPSAGPPAAGSDAPLYENHHPSAQSVWQRLSGRIVIREQTRSEADGRQLHAEYGQFDEGRYVYCANTFDRRQLVIVEPARAAMLEAYYQEIVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAJ6</accession>
    <name>A0A1W1IAJ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49899">
        <property type="protein sequence ID" value="SLM49899"/>
        <property type="gene ID" value="NSJP_3732"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3732"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="103" mass="11617" checksum="76E3225FC833FD0C" modified="2017-06-07" version="1">MPDVDAAGLEDTESIRRTDALSKPKGIMPPLEAVSFAQISRILELTDRLGLNREWVEIPLSPERPGLVRRLTNGKLEIVVDADEPFEHWLASLETRILETQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAJ8</accession>
    <name>A0A1W1IAJ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49793">
        <property type="protein sequence ID" value="SLM49793"/>
        <property type="gene ID" value="NSJP_3626"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3626"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="252" mass="27465" checksum="7BC9D4379B58938C" modified="2017-06-07" version="1">MNQVPLMTTDEHAQMSRRTFFRKAGLIGIGVSLMDLAPKVLLPSARAERTLASSSQSDPQTTQSRLRTRTELLTILQGHPGGAQAIETARRRGANFSLGTNPTQPPQVQGTPPVTLFSFSLLLVPGQLQVGQSWVMFHVVDILKNSAINLRVSSTKSWASFQIDFPKNGWYLLNIEGLQTSGGAISARLVKNEQGGPIVQTWSYPSVPGTSEQKPIHRSFPAMFEYTGGTKGAILYLDNGSFSFVQFSAESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAQ0</accession>
    <name>A0A1W1IAQ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Divalent metal cation permease, ZupT-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3960"/>
    <dbReference type="EnsemblBacteria" id="SLM50127">
        <property type="protein sequence ID" value="SLM50127"/>
        <property type="gene ID" value="NSJP_3960"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3960"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="250" mass="25959" checksum="93FFBA19EA0C7FAB" modified="2017-06-07" version="1">MLELISLGAVAGLIPIYLGIVAALVLGRVLPRAWEAGLIGVATGVLLYLFFDLMHESVELTGARDIMSWAVFLGGLGVSLVGLVWLESSQIFGSNQASRVLSLPYMIALGMGFHNLGEGLAIGASYASGQWTLSMLLVAGFALHNGTEGFGIVGAAGKTPLNGKDIFLLGLLAGAPTCLGTLLSGQGVSSYLSILFYTLAAGSLLYVILSLTAISYTATRRLQTSVGILLGISLMFVTSMLLTLVSGIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAU9</accession>
    <name>A0A1W1IAU9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Signal peptide peptidase SppA</fullName>
            <ecNumber evidence="4">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3991"/>
    <dbReference type="EnsemblBacteria" id="SLM50158">
        <property type="protein sequence ID" value="SLM50158"/>
        <property type="gene ID" value="NSJP_3991"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3991"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004635">
        <property type="entry name" value="Pept_S49_SppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00706">
        <property type="entry name" value="SppA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="3">
        <location>
            <begin position="123"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="328" mass="35243" checksum="94E92F621823C39C" modified="2017-06-07" version="1">MAHKLYQRTVKGAVRFCIAGAMLSLSGCITVNLIQPPGPVQETVLSGTGDGKVLLLDLSGVIASQDRDGIIPQPNMLATFKEELSRAAKDDKVKAVVVRVNSPGGTVTASDILYHELKTFKAAKRVPVVISMMDVAASGGYYLAMAGDSVLVHPSTVTGSIGVIMLTVNARGLLEKVGVEANAITSGPRKDMGSPFRMMTPEEKAIFQSVIDSFYQRFLTVVQEGRPNLSAEQIKKLADGRIYSGEQAKAAGLVDDIGYLEEAIEQAKKKAGLKEARVVTYRRPGEYQNNIYSHALQGTGSGFASLANIDLLSMVRGGTPQFMYLWMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAY6</accession>
    <name>A0A1W1IAY6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">pyrB</name>
        <name evidence="9" type="ORF">NSJP_3995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3995"/>
    <dbReference type="EnsemblBacteria" id="SLM50162">
        <property type="protein sequence ID" value="SLM50162"/>
        <property type="gene ID" value="NSJP_3995"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3995"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="155"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM50162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="306" mass="33167" checksum="BCA0390D9932CA99" modified="2017-06-07" version="1">MSLKRKDLLSLAPLSVEEITLILDTADSFKEVTGREIKKVPALRGRTVVNLFFEPSTRTRTSFELAAKRLSADVINFSPSSSSVVKGETLLDTARNIEAMQADIIVLRHPSAGAAEALARGVKSSVINAGDGWHEHPTQALLDLYTIRQRGLSFEGLKVAIVGDVAHSRVARSNIYALSKLGAEVRLIGPPTMMPWGVERLGARVYRNLDEGLAGVQVIMMLRLQLERQGRALFPTIREYARLFGLTGERVKLADPGAIVMHPGPINRGVEIAPEVADSLSSVILDQVANGVAVRMGILYLLSGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAZ3</accession>
    <name>A0A1W1IAZ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50170">
        <property type="protein sequence ID" value="SLM50170"/>
        <property type="gene ID" value="NSJP_4003"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4003"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043683">
        <property type="term" value="P:type IV pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043107">
        <property type="term" value="P:type IV pilus-dependent motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007445">
        <property type="entry name" value="PilO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04350">
        <property type="entry name" value="PilO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="186" mass="21215" checksum="6E0039416ED4C002" modified="2017-06-07" version="1">MNRLIEVLKSPYGPLAPWVGLTILLFGLLWLSMSFGVESADMQLARFEREWLQGRKAHQFHLEARQARKDLAEVWTALPDERDFAPLALGITDEAKRNHVALPALSYKTEPTPVSHITRGILQGTMTGKYEDLRRFLYDLETAEELVYIEDVDLMQAPEHQDQMLTFNIKIATYLKVSEALIGSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB05</accession>
    <name>A0A1W1IB05_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4019"/>
    <dbReference type="EnsemblBacteria" id="SLM50186">
        <property type="protein sequence ID" value="SLM50186"/>
        <property type="gene ID" value="NSJP_4019"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4019"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="105"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="293" mass="33303" checksum="D13DEEB98C5723A5" modified="2017-06-07" version="1">MGSGSSGLFTENNLRETILAGIRPKGKNDSFWDSQALRVHFSDKDLWRMSLSAQLIPKARSASDHLVDIGGTVFWIPLYLDLGYRHITILGREGHGFFPEYDLIRKEKFKLEMAVADADLDPYPIKSGSVQCVICFELLEHFAGDPMHFFEEANRILETNGIFCLSTPNVLWHQNLVNLFLGGHPFGWSLFTNSYADRHNREYTALELPVLLEAGGFATESLRTVTYEPRNWRREVLGYLLSFPGALARRVSFALRGETSIARAHKIGGVKDRYPEWLYILYGQPGVTFKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB09</accession>
    <name>A0A1W1IB09_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NSJP_3786</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3786"/>
    <dbReference type="EnsemblBacteria" id="SLM49953">
        <property type="protein sequence ID" value="SLM49953"/>
        <property type="gene ID" value="NSJP_3786"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3786"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013426">
        <property type="entry name" value="EpsH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026392">
        <property type="entry name" value="Exo/Archaeosortase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019127">
        <property type="entry name" value="Exosortase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09721">
        <property type="entry name" value="Exosortase_EpsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02602">
        <property type="entry name" value="8TM_EpsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04178">
        <property type="entry name" value="exo_archaeo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM49953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="328" mass="35956" checksum="D3DDF8D327663C07" modified="2017-06-07" version="1">MDARLIKPAAVVRLASREWQVIGLIVLATTVCVIGLFWPTVESLVAAWSSSRTFAHGFLMLPVTGYLVWCCRQAWLPLTPEPSAWGVVALSAIGAAWLVGHRLNLIWLEQLAVIASLPGLVWTLLGTTIARAISWPLGLLIFMLPVGTSIEPWLQDFTTLFILGGLRLVDVPYLIQEYRITIASGTWEVAPDCGGLRYLLPGLALSYAFATLVYQQPVRRFTFLGISAVILMIANGIRAYGIIMGDYMGVAEGADHRIFSYTIYGLTMPLLFWCALRWEETKNVVFLGSSANSDRGSHVMKQAAVMALVSLSVLAIAPLSVQLWGFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBD0</accession>
    <name>A0A1W1IBD0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Oxidoreductase</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_4054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4054"/>
    <dbReference type="EnsemblBacteria" id="SLM50221">
        <property type="protein sequence ID" value="SLM50221"/>
        <property type="gene ID" value="NSJP_4054"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4054"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="143"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="365" mass="40369" checksum="1B07644D1EFA1D6B" modified="2017-06-07" version="1">MSHQHTGSRLRVAVLGTGAFAETCHVPGLQSHPQAEVRAICGRRKDRAQYLADRFSIPIISTDYRELLSRSDIDAVTIVTPNSFHAEQACLALASGKHVFCEKPLATNLSDACEMVRVAEASGKVHQVAFTYRYLHGIRELRRRIYQGDIGVPHYVRAHYDCWDGLHPSFSAGFRDKLDLAGGGVLYDVGPHLFDLVSFVLGPIESVTGFSKMIPRHRRNVGPLIQEEVETDDFASAWFVHESGVRGQWFGSRVTPPLAERSFVEVIGDEGALRASLSRGGVDVLKVSTPSKPTWDELCLPDKTDDESPHCLGAMMRSFVDACLRGKLDGEVDASFYEGLAAQEGVAAVEEAMADMTWVRIRRYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBH3</accession>
    <name>A0A1W1IBH3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50239">
        <property type="protein sequence ID" value="SLM50239"/>
        <property type="gene ID" value="NSJP_4072"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4072"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="18"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="115" mass="12886" checksum="49F8EADDF621B463" modified="2017-06-07" version="1">MAHNEWEWPITVDFQKHNERVALLRPIPYEITAAAKDPAPSTRQGKALSVNISNGGMLLLMDHPPAIEQVLKVYVPTPTAVADTPTLAEVRWTRKLPFSHSNGFGPYFVGLKFMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZJ9</accession>
    <name>A0A1W1HZJ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Lipopolysaccharide core biosynthesis glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46175">
        <property type="protein sequence ID" value="SLM46175"/>
        <property type="gene ID" value="NSJP_0003"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0003"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="258" mass="29323" checksum="EDA452C64F95F498" modified="2017-06-07" version="1">MPAVTALIITKNEEINIADCLASVRWTEERLVIDAESKDRTAELARAAGADVVVRPWPGFGPQKNFGMERAASDWILIVDADERVPGPLAEEIRSLLSRWTEGDPVAYEIPRMNFYYGAWIRHAGLYPDYQIRLVRKGTAAYNDVPVHENLIVRGTIGKLVQPFEHQTERRIDDHFRKFGLYTTLAAREKGRTVSTVRRRDLLARPLVVFLKTYLLKRGYRDGVRGLIVCLFASMYTFVKYAKLWDATRTPAASRGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZK7</accession>
    <name>A0A1W1HZK7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0002"/>
    <dbReference type="EnsemblBacteria" id="SLM46174">
        <property type="protein sequence ID" value="SLM46174"/>
        <property type="gene ID" value="NSJP_0002"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0002"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="196"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="387" mass="42563" checksum="23C2D1832072E7BA" modified="2017-06-07" version="1">MAQRILYIHGVGAVGGAEHDLLAVLARLDRAAWEPHVVCPAEGPFRTLLEREGLTVHPLALVPWRKWFSPFVRWRSVGRLRDLVDRLRPALLHVNDIWWVPHTLGALRGAAASPPIVAHVRQEIEPEKVRRYELDRIERVIGISEHVAESLKAGGVETRKLRMVYSGIDFSRRAETAAGGDRSDVAEVRRRLGVPAAALLLGTAANLFPRKGYEVMLRALPGILAVHPDVHYLLAGTAEPAYAASLRALAVDLGITERIHMVGFQDPIRPFLDALDLYVHPALMEGFGIALVEAMAAGKAVVATRTGGVPEVVEQGETGLLVAPGDSERLRAAVLELLGDEPRRVRMGAKGFSRARARFDLDRTVADLERIYREAVVEQRGGHADRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I050</accession>
    <name>A0A1W1I050_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">mutL</name>
        <name evidence="7" type="ORF">NSJP_0180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0180"/>
    <dbReference type="EnsemblBacteria" id="SLM46352">
        <property type="protein sequence ID" value="SLM46352"/>
        <property type="gene ID" value="NSJP_0180"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0180"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_mis_repair" evidence="6">
        <location>
            <begin position="215"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="MutL_C" evidence="5">
        <location>
            <begin position="407"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="596" mass="64591" checksum="01C17F5CEF9BABAB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I089</accession>
    <name>A0A1W1I089_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0248"/>
    <dbReference type="EnsemblBacteria" id="SLM46420">
        <property type="protein sequence ID" value="SLM46420"/>
        <property type="gene ID" value="NSJP_0248"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0248"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="73"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="272" mass="30633" checksum="D938AE8A7A3720C4" modified="2017-06-07" version="1">MGIGKDIERRGHVVGFREEIANAAGQGDDYFFGWFDNGKDKESSFIRGHWDFMFHIALPMAPYMANPEDKVALEIGHGGGRLLAAASRSFRQVIGTDIHNHNAQVVEALRERGVCNSLLFKTDGTTLPVPSNAIDCVYSFIVLQHVEKFSVFKRYLEETYRVLRPEGVAVLYFGRKYGWSFNRSSRWLYLADRFTERFRLGRGFEELPARVNGTNLKVSLSHASDLAIAMGFSVLHTLVSRRRVPDGIARYGGQNGMVLRKPGASSDRRIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I096</accession>
    <name>A0A1W1I096_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, group 2 domain protein (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0239"/>
    <dbReference type="EnsemblBacteria" id="SLM46411">
        <property type="protein sequence ID" value="SLM46411"/>
        <property type="gene ID" value="NSJP_0239"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0239"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="322" mass="36388" checksum="DDE1E44CFB931A39" modified="2017-06-07" version="1">MQLAPIAVFAYNRSEHLQRTLAALSRCDWADRSTLIVYSDGPKTAGDAGAVRRVREIVQAAVGFADVRIVNRTQNFGLARSIITGVTELCRAHGRVIILEDDLVVARGFISYMNQALERYENDRTVMQVSGYVLPMPNVSCLGETFFCRVASSWGWATWERAWNCFCSDPAALLERLASSERRRQFDVEDSYPYYAMLQQHAAGKLDVWGVRWYASMFLQGGLCLYPTESLVQNIGMDGSGMHCHPSTTFDVRLSDKDRWAFREPVGESGEAIEMISKFFRTMRNGNAAAAQRATPWMRRMVHTCRSLAERVSRSIGRREVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0A1</accession>
    <name>A0A1W1I0A1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0258"/>
    <dbReference type="EnsemblBacteria" id="SLM46430">
        <property type="protein sequence ID" value="SLM46430"/>
        <property type="gene ID" value="NSJP_0258"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0258"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="294" mass="32945" checksum="A5113DDC2AAF8FB6" modified="2017-06-07" version="1">MIPQIRSRVLWIVMSGLVLLLASVHLMIGGLDQHEEKSQRLRFLPDGHFLRTASLGYRELTADVLWLQAIQVMGERKVSPEAGRWIYRLLDVVTTIDPKFTWAYEAGGIALCTLVVLPEESNRLLEKGMLHNPEEWKFPFLLSINYAFELGEDAKAAEAMALAAQLPGAPSNLGRLAANFFVSAKAPQQAIDLLSDLYEKTSDPGTKSLLGERLKRVAVERDLQLIEGSIARYRQSHGGLPSRLEDLTTSGILEKLPIEPYGGRYEYDPHSGTVRSSEISERMTLSMKRRRDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0B3</accession>
    <name>A0A1W1I0B3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">serA</name>
        <name evidence="9" type="ORF">NSJP_0264</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0264"/>
    <dbReference type="EnsemblBacteria" id="SLM46436">
        <property type="protein sequence ID" value="SLM46436"/>
        <property type="gene ID" value="NSJP_0264"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0264"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4 5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="6">
        <location>
            <begin position="3"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="7">
        <location>
            <begin position="106"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="PGDH_inter" evidence="8">
        <location>
            <begin position="323"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="527" mass="56538" checksum="C6BBCC5D96922B03" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0B6</accession>
    <name>A0A1W1I0B6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_0259</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0259"/>
    <dbReference type="EnsemblBacteria" id="SLM46431">
        <property type="protein sequence ID" value="SLM46431"/>
        <property type="gene ID" value="NSJP_0259"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0259"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="593"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="686" mass="75735" checksum="0CF4701CCD590846" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0F7</accession>
    <name>A0A1W1I0F7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0292"/>
    <dbReference type="EnsemblBacteria" id="SLM46464">
        <property type="protein sequence ID" value="SLM46464"/>
        <property type="gene ID" value="NSJP_0292"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0292"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
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    <dbReference type="Gene3D" id="2.60.120.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1610">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1214"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF1254"/>
    </dbReference>
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        <property type="entry name" value="DUF1254_sf"/>
    </dbReference>
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        <property type="entry name" value="DUF1214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06863">
        <property type="entry name" value="DUF1254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012190337" evidence="1">
        <location>
            <begin position="26"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1254" evidence="3">
        <location>
            <begin position="97"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1214" evidence="2">
        <location>
            <begin position="411"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="537" mass="58631" checksum="4524DC559986D4BB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0F9</accession>
    <name>A0A1W1I0F9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_0313</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0313"/>
    <dbReference type="EnsemblBacteria" id="SLM46485">
        <property type="protein sequence ID" value="SLM46485"/>
        <property type="gene ID" value="NSJP_0313"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0313"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="254" mass="27599" checksum="953A20FC4FCA3A87" modified="2017-06-07" version="1">MGMSGRRPIIRVAHVTAGYGDVVVLDDLTFDVYPGEVFVILGGSGCGKSTLLKHMIGLHRPVQGSILIEGRDIASAEGPERLKILTGIGVMYQQGALFGSMSLLENVRLPLEEYTDMPDEAMDRVAMMKLQLVGLGAAAYKLPDEISGGMRKRAAIARAMALDPPILFLDEPSAGLDPVTSAELDHLIVGLARALRITFVVVTHELASIDTIADRVIMLDKRTKGIIAEGKPQELRDHSDNPWVRQFFNREAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0L3</accession>
    <name>A0A1W1I0L3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_0364</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0364"/>
    <dbReference type="EnsemblBacteria" id="SLM46536">
        <property type="protein sequence ID" value="SLM46536"/>
        <property type="gene ID" value="NSJP_0364"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0364"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="122"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="469"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="519"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="853"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1378" mass="148763" checksum="F7EF4CB4B1F9B70E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0N7</accession>
    <name>A0A1W1I0N7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46565">
        <property type="protein sequence ID" value="SLM46565"/>
        <property type="gene ID" value="NSJP_0393"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0393"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="134" mass="14810" checksum="AE55451BD3D62EB8" modified="2017-06-07" version="1">MDTVKEDTIRVLIVDDIKAIRESLRNILAAYPGMTVVGEACDGEEAVLRVHQVRPSVVVMDISMPRLDGINATARIKQAFPHVVVIGISVYATEETRQTMRAAGATTVISKDMAVDQLRDEIFESVNRRSTAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0N9</accession>
    <name>A0A1W1I0N9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sel1 domain protein repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46570">
        <property type="protein sequence ID" value="SLM46570"/>
        <property type="gene ID" value="NSJP_0398"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0398"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="59" mass="6513" checksum="FF49EB861ECC1ECA" modified="2017-06-07" version="1">MCDYVQAYAWYSKAYAISGSLEHKSGLDTLKSKMQPADIERAHSFDAGTSVSTKRSPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0U1</accession>
    <name>A0A1W1I0U1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46620">
        <property type="protein sequence ID" value="SLM46620"/>
        <property type="gene ID" value="NSJP_0448"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0448"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="71" mass="8200" checksum="F74BCAEF2F8B26C7" modified="2017-06-07" version="1">MGRAARYIRAAVFSVKERKWKEPSYDQQAEPMACLLADRIDARLGLRDGAERYGAAQGQHRQHRAKRFRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1I0</accession>
    <name>A0A1W1I1I0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0672"/>
    <dbReference type="EnsemblBacteria" id="SLM46844">
        <property type="protein sequence ID" value="SLM46844"/>
        <property type="gene ID" value="NSJP_0672"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0672"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012031788" description="FGE-sulfatase domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="321" mass="35312" checksum="3679B375CB43AA7D" modified="2017-06-07" version="1">MRSHTVLQVGLGVALAAGSLSMASAGDQPSRDKDMVPIPKGEFTMGSNEHSDETKHQVVLDAYLIDKYEVSNARYKEFMSATGHPAPAYWDDPRLSKPNQPVVGVSWTDANAFCKWEGRRLPTEAEWERAAKGPEGDNHYPWGHKLDPQKANYGQNVGRTMPVDSYPEGVSGFGVYNMAGNVFEWVEDWYDPKHYKESIALNPKGAEKGYNFANQGPVKVLRGGSWLAPETSLHTSHRFWNQPDNNSYGVGLGFRCAKAAPAISDEAVQAGRDAFIAALVAMGAEKHAEAMTSIERALAADPGHKEYLATRDLIKRSMTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1I5</accession>
    <name>A0A1W1I1I5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46868">
        <property type="protein sequence ID" value="SLM46868"/>
        <property type="gene ID" value="NSJP_0696"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0696"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="70" mass="8228" checksum="5A4B601E0D192903" modified="2017-06-07" version="1">MPKRHKSMSEFAHSTLSLTEFLEEDPDLDIVEQIFIENHIYVVRSAYGAWKRRHPSERNHTGESSKKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1L1</accession>
    <name>A0A1W1I1L1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0702"/>
    <dbReference type="EnsemblBacteria" id="SLM46874">
        <property type="protein sequence ID" value="SLM46874"/>
        <property type="gene ID" value="NSJP_0702"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0702"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="260" mass="29031" checksum="40050D8A56C28F42" modified="2017-06-07" version="1">MTERFEVTLNTPAGRLTTALDVPTEFIPITAVVPIARRLGEEAGHLEEYQARERGQTISCRMGCAACCRMLVPVSPPEAFALRHYIEQLPAERRMRVTERLAESRMTLEAHGLWDRLWAIADAGKAVSDEELDPLNRAYYALRHPCPFLENEICGIYEARPAACRELQVTSPAEYCADLVNNPVVALPVSMRIGTILGLLWASVTGTSPRLVPLPVALDWAGKHNGPAGRTWPGSQLIDELLDKMWRFLSQEFEARKVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I259</accession>
    <name>A0A1W1I259_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46949">
        <property type="protein sequence ID" value="SLM46949"/>
        <property type="gene ID" value="NSJP_0777"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0777"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="55" mass="6107" checksum="1A2796C94FBC0D37" modified="2017-06-07" version="1">MIRLVNNYRSDQVALTAPTTTQLRTLIESYCHIALKEGSLYHSGENGSKNVNQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I260</accession>
    <name>A0A1W1I260_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator in two-component regulatory system with KdpD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kdpE</name>
        <name evidence="5" type="ORF">NSJP_0889</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47061">
        <property type="protein sequence ID" value="SLM47061"/>
        <property type="gene ID" value="NSJP_0889"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0889"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="131"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="131"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="231" mass="26130" checksum="FF1C9BE0853044A1" modified="2017-06-07" version="1">MSGQDVTVLVIEDEPEIRRFLRATLPAHGFRLLEATTGRQGLVDAKARTPDLILLDLGLPDLDGIEVIRLVREWTVTPIIVLSARDQEPMKVEALDLGADDYVTKPFGVSELLARMRTALRHVARIADAGESVFSIQGLRVDLGRRQVFVAGKEIHLTPIEYKLLTALVRHAGKVLTHRQLLKEAWGPLHVEESHYLRVYMRQLRNKVEINPAHPRYLVTELGVGYRLRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I277</accession>
    <name>A0A1W1I277_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable lipid II flippase MurJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mviN</name>
        <name evidence="8" type="synonym">murJ</name>
        <name evidence="10" type="ORF">NSJP_0936</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the MurJ/MviN family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0936"/>
    <dbReference type="EnsemblBacteria" id="SLM47108">
        <property type="protein sequence ID" value="SLM47108"/>
        <property type="gene ID" value="NSJP_0936"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0936"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015648">
        <property type="term" value="F:lipid-linked peptidoglycan transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13123">
        <property type="entry name" value="MATE_MurJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02078">
        <property type="entry name" value="MurJ_MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002869">
        <property type="entry name" value="MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="538" mass="57168" checksum="A9C27D80EEFC4D4C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2D1</accession>
    <name>A0A1W1I2D1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47142">
        <property type="protein sequence ID" value="SLM47142"/>
        <property type="gene ID" value="NSJP_0970"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0970"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="7"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="108" mass="12384" checksum="68747EA258282959" modified="2017-06-07" version="1">MNGQDGQDRRGRRLKVSHRLFFFGEDEFEGEATILDISTGGCQATSQTEVKCGMVLKLSLFLQDQPWPLRIDDSIVRWVKEQTFGLEFLGIRPAQRERLRAILMKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2J0</accession>
    <name>A0A1W1I2J0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1033"/>
    <dbReference type="EnsemblBacteria" id="SLM47205">
        <property type="protein sequence ID" value="SLM47205"/>
        <property type="gene ID" value="NSJP_1033"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1033"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="320" mass="36499" checksum="373C81AC419D2628" modified="2017-06-07" version="1">MELKIPSREQAYWGLRAMKTVAMADGALDDAEVHLMTAVQRVFGTDHPLEQLEPITPAELAAALPDRQIRRQLVNGFIVMSLIDRDASKAEADLVSQFAHALEVSSPEVNDLRHVVEREMFHLRLDLARRVWLREKVKEIWETNGIRGIYRFMRGMVGRYEDAALAGRYKALEQYPTGSLGRAYWEYCRTNGFAFPGEKGGAAEPILFHDCAHVLSGYGTDPEGEVQVACFSAGFQRRDPFLFVFFVLLQFHVGVRMTPITKARTGFFDPEKALIALRRGAAMNVDLNNGWDPWPVLRDQVEDLRRRYNIPPKESFQPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2R2</accession>
    <name>A0A1W1I2R2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47306">
        <property type="protein sequence ID" value="SLM47306"/>
        <property type="gene ID" value="NSJP_1134"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1134"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="136" mass="14175" checksum="4B3DB8C7C233F127" modified="2017-06-07" version="1">MHVRITATAAANRYGFSAAGLAFGLLCGLTVWLGSGIASAATSAQDPKHFVVDVVAISGEEFVVKDEAGTEAKIHVGTDTEKFGHIQPGDRIDAWVLPNGHAKTIMILRSAAFLQLERNGSQPGGSSGTASESPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2T1</accession>
    <name>A0A1W1I2T1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="10">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alpha-IPM isomerase</fullName>
            <shortName evidence="10">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">leuD</name>
        <name evidence="12" type="ORF">NSJP_0961</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the LeuD family. LeuD type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0961"/>
    <dbReference type="EnsemblBacteria" id="SLM47133">
        <property type="protein sequence ID" value="SLM47133"/>
        <property type="gene ID" value="NSJP_0961"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0961"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 10" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="11">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM47133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="207" mass="23531" checksum="3079A261E2869234" modified="2017-06-07" version="1">MHAFTQMTGLVAPLDRVDVDTDQIIPKQFLKTIKRTGLREGLFYDWRKRKDGSPDPEFFLNQPRYHDATILLTRDNFGCGSSREHAPWALLDQGFRCVIASSFADIFYNNCFQNGILPVVLRSDDIQSLMKDVLATEGYTLAVDLGRQTVTAPAGVSYRFEIDPFRKDCLYRGLDAIGLTLQHEPAISAYEAKRKHEAPWLFLDLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2T7</accession>
    <name>A0A1W1I2T7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1148"/>
    <dbReference type="EnsemblBacteria" id="SLM47320">
        <property type="protein sequence ID" value="SLM47320"/>
        <property type="gene ID" value="NSJP_1148"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1148"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.290.11">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009794">
        <property type="entry name" value="DUF1362"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036698">
        <property type="entry name" value="TM1070-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07100">
        <property type="entry name" value="ASRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008711">
        <property type="entry name" value="UCP008711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89232">
        <property type="entry name" value="SSF89232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="125" mass="13864" checksum="73DF0FADC4B47530" modified="2017-06-07" version="1">MTSIGKRRWAVAEGYIPATSTGPHPQMTSHETLCLLNAGNRDAHVQVTVFYRDREPVGPYRIIVPARRTLHLRLNDLSDPAPIPVDTDFATVIDSDVPIVVQHTRLDSRQAENALMSTVAFACDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Y7</accession>
    <name>A0A1W1I2Y7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxygen sensor histidine kinase NreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NSJP_1190</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47362">
        <property type="protein sequence ID" value="SLM47362"/>
        <property type="gene ID" value="NSJP_1190"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1190"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="14">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="322"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="14">
        <location>
            <begin position="448"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="122"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SLM47362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="579" mass="63698" checksum="C406FB07B49FF687" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I379</accession>
    <name>A0A1W1I379_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase C14 caspase catalytic subunit p20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1253"/>
    <dbReference type="EnsemblBacteria" id="SLM47425">
        <property type="protein sequence ID" value="SLM47425"/>
        <property type="gene ID" value="NSJP_1253"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1253"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="954" mass="104290" checksum="327A7B4741232B52" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3M6</accession>
    <name>A0A1W1I3M6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="SLM47594">
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        <property type="gene ID" value="NSJP_1422"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1422"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021796">
        <property type="entry name" value="DUF3365"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11845">
        <property type="entry name" value="DUF3365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013275118" evidence="1">
        <location>
            <begin position="25"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="191" mass="21164" checksum="59FAD3AA087FC0EA" modified="2017-06-07" version="1">MMNALVCLALSLFLLNVLPTVSMASDQEAIPPGTVADYIHAILEADRTFYTIHVVERMQKGQGPAASEDWRAKKNLLPLPAQFLKESGDLAAKTGSTVRYRLISLWPINPDNGPYGEIERKGLETVRDHPDRTATARVTVGTQVYFQAIYPDHAVSETCIACHNTHPRSPKHDFKMNDVMGGLLIEIPLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3T2</accession>
    <name>A0A1W1I3T2_9BACT</name>
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        <recommendedName>
            <fullName evidence="3">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gdhA</name>
        <name evidence="9" type="ORF">NSJP_1494</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
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        <property type="protein sequence ID" value="SLM47666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1494"/>
    <dbReference type="EnsemblBacteria" id="SLM47666">
        <property type="protein sequence ID" value="SLM47666"/>
        <property type="gene ID" value="NSJP_1494"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1494"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="8">
        <location>
            <begin position="184"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        <location>
            <position position="222"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="418" mass="45431" checksum="A7DD1DE322599E9B" modified="2017-06-07" version="1">MHELDTPTFRLAVAQFDQAAEAMGLDPNLRERLKYPQRSLVVSIPVRMDDGRVQVFTGYRVQHDTSRGPSKGGIRYHSDVSLGEVAALAMWMTWKCALADLPYGGAKGGVTVNPKQLTSGELQRLTRRYAAEILPIIGPDKDVPAPDVGTDAQVMAWIMDTYSQQVGYAVPGVVTGKPLSIGGSLGREEATGRGVVYVTLEALRHLDLDIQKATVAIQGFGNVGAHTARIMQECGARVIAVSDVGGGIYNPKGLDIPLLLSRYKEAGTPLGETKLGDALSNEELLQLDCTVLVPAALSEQITGRNASMLRCKILAEGANGPTTLEADRIVQDKGIFVIPDILANSGGVIVSYFEWVQDAQRFFWKASDIQERLHDLMTAAFQRTLQFAETRRTSMRMAALMSGIDKVAQAHQHRGLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3T4</accession>
    <name>A0A1W1I3T4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">NSJP_1490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="NSJP_1490"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1490"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012845483" evidence="1">
        <location>
            <begin position="25"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="177" mass="19374" checksum="8B20AC386CA45D23" modified="2017-06-07" version="1">MSAIVRAAMLTCMSLAAMCLSVSAGSAEPYELSKNDVMDAKSIKSSEVSLFGVKLGDSEAKALDVLVNEKIPGVKVEQEALFIFLLDQRKPTGPMAGVRVQDGKVDLIFVNNRFAYKTRGVFRNVLNSESPEDVRKLLGQEDYGDENVMGAVLAYDKQGFVINYLGKDVNIEFSPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3V6</accession>
    <name>A0A1W1I3V6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47549">
        <property type="protein sequence ID" value="SLM47549"/>
        <property type="gene ID" value="NSJP_1377"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1377"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="140" mass="15672" checksum="B393E6B85B49F70C" modified="2017-06-07" version="1">MMRRSRQFFVLPILAAALVLDGCNVARITLNTPITMNDVTFIEPGRTHLSDVIAKLGAPDSMTDSDNGVVVTYRFLDMRYSRVNLGWLAKPWSPVDPDLIFSRLGLGVDAFQVLCDSGFVVQHRSFLRHLAGPQFTPYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Z2</accession>
    <name>A0A1W1I3Z2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47726">
        <property type="protein sequence ID" value="SLM47726"/>
        <property type="gene ID" value="NSJP_1554"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1554"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="161" mass="18120" checksum="A8313CDE0900CCBA" modified="2017-06-07" version="1">MREATWAVWGLIGLAVLSGCSAARHHHGMMDHGKGEAYWQKGQQEMAALVDRTVNDQDKAKRVKGIVGDIITELKAGREQERAYHQQLFALNANYAAAPEEFMKILDEANNQRMRTATTVLGQRFRMKELMTADEWKVLSDQMSAYSGRYQHDGTGAKTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4A7</accession>
    <name>A0A1W1I4A7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein HelA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">helA</name>
        <name evidence="4" type="ORF">NSJP_1664</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47836">
        <property type="protein sequence ID" value="SLM47836"/>
        <property type="gene ID" value="NSJP_1664"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1664"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004763">
        <property type="entry name" value="CzcA/CusA/SilA/NccA/HelA/CnrA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00914">
        <property type="entry name" value="2A0601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="868"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="894"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="919"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="966"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="997"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1048" mass="114609" checksum="7BBB776A36EE6CBA" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Q8</accession>
    <name>A0A1W1I4Q8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47869">
        <property type="protein sequence ID" value="SLM47869"/>
        <property type="gene ID" value="NSJP_1697"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1697"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="215" mass="23466" checksum="FE1BA637BFA5A69D" modified="2017-06-07" version="1">MDKVLMRAGAVMVLLVGGLIGSGCGGSGQTVHLDVVPKPMPAQMAEPEAVKIVVVPFEDRRMEKSRVGMRTHLWGGVTYFNTKGDKPGDAYAQALAERLRARGWHDRSWDVRVLPAGSENSADIVITGQIVDLSANAKSRMFSTALTSSSKVTISAHNNADKTTTNRTIEGAQTDTVFWFTDSDIQKVLTATIKDTIDRYVEDTTISQRTLRPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4T2</accession>
    <name>A0A1W1I4T2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1834"/>
    <dbReference type="EnsemblBacteria" id="SLM48006">
        <property type="protein sequence ID" value="SLM48006"/>
        <property type="gene ID" value="NSJP_1834"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1834"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024442">
        <property type="entry name" value="Transposase_Zn_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12760">
        <property type="entry name" value="Zn_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS1595" evidence="1">
        <location>
            <begin position="136"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="300" mass="34109" checksum="7954A48ED234C688" modified="2017-06-07" version="1">MTKPSQTLSQMMKRFKDEDACKAFLKERRWPNGVRCPRCNNEKVFQPKSRPFHWICKAKDCGGRNGYRFSVITKTIFENTNYPLTTWFQVIFLMMTSKKGISALQVQRMIGSGAYRTAWYMCHRIRAAMKDGGFGQLMGEVEVDETFIGGRQKNRHRSKRHLNVAGPKGKVAVIGAIARKGNVVARIIENVSADTLTQFVKQTVDANVSLVATDDAGGYRFLRQNGFPQHQSVRHLSGEYVRGNVHTANLDSFWSLLKRGVMGTFHNVSKAYLPLYLAEFSYRHNNRKNANIFADVIAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4U5</accession>
    <name>A0A1W1I4U5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Cell division protein FtsQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_1737</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1737"/>
    <dbReference type="EnsemblBacteria" id="SLM47909">
        <property type="protein sequence ID" value="SLM47909"/>
        <property type="gene ID" value="NSJP_1737"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1737"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090529">
        <property type="term" value="P:cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026579">
        <property type="entry name" value="FtsQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35851">
        <property type="entry name" value="PTHR35851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="8">
        <location>
            <begin position="78"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="288" mass="32816" checksum="3738B3EFA1BF7A48" modified="2017-06-07" version="1">MIRWFRKKKVGEPAYRQNSWKGSRGLIEIDRRQRRWARVRPTWNPKMRIAAWAAGLTMGVWAVIVGASHLAPIIEHGLEIREIQIQGVHHVAREEVLQRLALKNGTSLHRISLPFLAERLRTIAWIKEATLERLPLHTLRVTVVERQPAAIARVGSEFLLLDEEGVVLTRLGDQDQPSLPLVIGATQKILLQGESGLRRTVQASIELARTMAHTVEGRVEIDVSDPLNLVASAKGMRFQFGHDALLDQWNRFRMVKAVFKPGTLDGRKRELGEVDLRYDNRVIVRERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4X4</accession>
    <name>A0A1W1I4X4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47981">
        <property type="protein sequence ID" value="SLM47981"/>
        <property type="gene ID" value="NSJP_1809"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1809"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="246" mass="28768" checksum="8F6CD6F74C56BF59" modified="2017-06-07" version="1">MQKPQDAHSYIGLSGYSYKPWQGVDRFYPPGLKQTEFLGYYATRYRTVELDGTWYRIPAESMVQRWIASTPSDFLFAPKVHRQITHQYRLKPESVPLVGVMLDRLKPLLQQNRLGPLLIQLPPNFSRDEDRLGRFLERLPTTIRWAVEFRHTSWNQPSIESLLKHFNVSWVAADTDDSPAQWHHTADFWYVRLRRTTYGPEALQAWARRIAEAVGQGEDCFVYCKHEDEGSPWQWADALLSGLETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I541</accession>
    <name>A0A1W1I541_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TNase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48138">
        <property type="protein sequence ID" value="SLM48138"/>
        <property type="gene ID" value="NSJP_1966"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1966"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012122228" description="TNase-like domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="3">
        <location>
            <begin position="25"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="163" mass="18280" checksum="44D18BB1B47FF292" modified="2017-06-07" version="1">MVRHSFAFALVILGTFAALSDLSAAELVAKVISIEEGDRLTIRHSGRTETIYIKDIDCPQLTQPYGKQAKRVTTAFVANRDVIIRGLAADKQKRLSAEVVLHDGRSLGRELLKEGLAWWKRSPAADQRLELLEELARAGGKGLWSDPKPIPPWEWKQQAKVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I549</accession>
    <name>A0A1W1I549_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48122">
        <property type="protein sequence ID" value="SLM48122"/>
        <property type="gene ID" value="NSJP_1950"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1950"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="113" mass="12820" checksum="EE8FB4D60831E51C" modified="2017-06-07" version="1">MGQPENLHDDASGEFVRLSLYLYLLPKMLGDAGTQEASLRTFHDHYEVAGRRRAIELVASPDTQYDMTVPTGIESRRSHIRISSFPHLTQRPMSKPLHDHAYVSEFIQVGSCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5A5</accession>
    <name>A0A1W1I5A5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48069">
        <property type="protein sequence ID" value="SLM48069"/>
        <property type="gene ID" value="NSJP_1897"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1897"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="41" mass="4820" checksum="BFECAEC057BE156C" modified="2017-06-07" version="1">MEIKKEYALRGKWQRRLIRHARVPVVVPSAQFLVEDLGTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5F9</accession>
    <name>A0A1W1I5F9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48257">
        <property type="protein sequence ID" value="SLM48257"/>
        <property type="gene ID" value="NSJP_2085"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2085"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018592">
        <property type="entry name" value="DUF2024"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023122">
        <property type="entry name" value="NE1680-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09630">
        <property type="entry name" value="DUF2024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160766">
        <property type="entry name" value="SSF160766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="85" mass="9508" checksum="190979F0F8D822A0" modified="2017-06-07" version="1">MADTVHIFDAKVRGKQGPLHFDVITTDEATALKLAKRYMEELGEGDVTVTVNECQFCHSEPLVMFSTDQQRQFHEQGGFIVPLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5H7</accession>
    <name>A0A1W1I5H7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DNA-binding protein, Excisionase family (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48083">
        <property type="protein sequence ID" value="SLM48083"/>
        <property type="gene ID" value="NSJP_1911"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1911"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="103" mass="11544" checksum="8CEB48729E0EA27A" modified="2017-06-07" version="1">MLTIKDLSARLNIKVSTLYAWVAQGKIPCRKIYGLIRFEPEEIDRWLTSLQPPPLSSAPCRISSPDTDIDRLIADAKRTAYTPRHGETISPSPEGKEHDDGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5K0</accession>
    <name>A0A1W1I5K0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48292">
        <property type="protein sequence ID" value="SLM48292"/>
        <property type="gene ID" value="NSJP_2120"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2120"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="157" mass="17090" checksum="6BF888CEFBF7ED0A" modified="2017-06-07" version="1">MRIHAAHRWDSTGARARFYAESSVAASSEAVLPFAGMHSSYRLLSYALILLWAWPAPPAAAQSPSDFTATTEQSCSFGMAKGEASQHCQVPIPAGCLVARIPGTTKPWTTISKGGKMTCQFQEKQTDWKTKITGTCGRCGTEHCSVQFIVRFDCTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5M5</accession>
    <name>A0A1W1I5M5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Imidazolonepropionase</fullName>
            <ecNumber evidence="2">3.5.2.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.2.7" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2145"/>
    <dbReference type="EnsemblBacteria" id="SLM48317">
        <property type="protein sequence ID" value="SLM48317"/>
        <property type="gene ID" value="NSJP_2145"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2145"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="56"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="404" mass="42074" checksum="124DA8CD4B1ADAA4" modified="2017-06-07" version="1">MTRVLAIRSARVIDGTGRVWENATVIVRGDRIAAVGGQRDLSVPRGARIVDGRGLTLLPGMIDCHVHLCLGSEADVVAAVEQESPSLTLLKAAHRARQTIDAGITTVRDVGSRDHSIFALQRAIDAGILPGPRIVGSGLAICMIGGHARFIGREVEGEAQVRTVAREQLAAGAGVIKVIASGGVLTPGTSPDVAQMTVRELAAAVAVAGEAGKKVAAHAHGASGMKNAIRAGVHSIEHATLLDDETVGLMREHGVFAVPTLSALATTAACRRGCGIPDSVLEKARGMTKRHQRSFAQAYRSGVRIAMGTDAGTPFNFHGENAQELERMVALGMTAMNAILSATAEAAELVGLQNTLGTIQPKRQADLLLVDGNPLKRIGVLCEPDRIVGVMKAGRFVSGPLAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5N9</accession>
    <name>A0A1W1I5N9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48314">
        <property type="protein sequence ID" value="SLM48314"/>
        <property type="gene ID" value="NSJP_2142"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2142"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013026305" evidence="1">
        <location>
            <begin position="32"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="201" mass="21982" checksum="67E6E0D56D90CCE2" modified="2017-06-07" version="1">MTSSLKVPVSHIWKALSLSLLTFTLASGCHHQPFDPTPVVPASSTLPYSAKVKVSEVGTFEVEPGASMGADPQLQSRVSRTIPPLLSTNDPTDWERATVKYLTTRKTFRSVVQEGTADLDLTLRINMYVDPSVGSGFSQIYLAVMDATLSDPRTGRSLMKYSGFGKMPGDEKDKGAMERALHAALRDVFSKMESDKRLLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5P1</accession>
    <name>A0A1W1I5P1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1971"/>
    <dbReference type="EnsemblBacteria" id="SLM48143">
        <property type="protein sequence ID" value="SLM48143"/>
        <property type="gene ID" value="NSJP_1971"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1971"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="187" mass="21107" checksum="5EDFA3CB606E221C" modified="2017-06-07" version="1">MALTFPSDARLKDASPVQLVLAGEHDVEPLRSLYRVIVEEGNSYPHDRFPDHDEFMDYWFRGKTTVAAYGPDRDQAHHMAGAFYLKPNWPGRAGHVANAGFIVAPAWRGTGLGWLLGTTMLDYARQLGYRSVIFNLVFSENLRARRLWERLGFSQLGMVPGAVRKNDGSYQDAIVMFRSLIDSPPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Y2</accession>
    <name>A0A1W1I5Y2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48400">
        <property type="protein sequence ID" value="SLM48400"/>
        <property type="gene ID" value="NSJP_2228"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2228"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="232" mass="25448" checksum="543E5F9AC378951F" modified="2017-06-07" version="1">MNEMWQEAMIEAYREMMRRTALFFPKLMALVTFLMLGVAIGWLVKLLLMRILKAVRFDAMCERMGLTPTLGKAGMKQPVSRLLGRASFWVVFLFFAFMGVDALDLPATANLMSAILGFLPHIVAAILVALVGILLGNFSSEAVLIAAVNAQIQGARLIANLVRWGVVIFTTAMVLTQLGIAKEIVIAAFSIIFGGIVLAMALALGLGGRHIAKEALERRLRREKTGDEFTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I630</accession>
    <name>A0A1W1I630_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48467">
        <property type="protein sequence ID" value="SLM48467"/>
        <property type="gene ID" value="NSJP_2295"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2295"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="228" mass="25316" checksum="A0647AB72DDD2503" modified="2017-06-07" version="1">MTLKLLLLSWKLSFVLIAFQGCIVISYGTYSSPAISDSITIDRKESLHWYGRRKGDVLALPNLRLEVLPINERVTISIWGLIVPFLPLPGGSNESALYSPFQFLMTLRILDGDDKLTLLPGEIVLQFHDGKSIRPSAFWGPQSGPANCRAYENTKVRQAATPITPTHESLAITTGTCVTLLFDRSPPPPDEEFSLLVKGIRQGGKPIGVPAINFQRESMWVMERAHDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6P8</accession>
    <name>A0A1W1I6P8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative NHL repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_2483</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2483"/>
    <dbReference type="EnsemblBacteria" id="SLM48655">
        <property type="protein sequence ID" value="SLM48655"/>
        <property type="gene ID" value="NSJP_2483"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2483"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="156"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="208"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="262"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="310"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="350"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="401"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="459"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="685"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="718"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="764"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="814"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="872"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="923"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="959"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="988" mass="106460" checksum="99945CE21B42C9DB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6U0</accession>
    <name>A0A1W1I6U0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">infA</name>
        <name evidence="5" type="ORF">NSJP_2361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2361"/>
    <dbReference type="EnsemblBacteria" id="SLM48533">
        <property type="protein sequence ID" value="SLM48533"/>
        <property type="gene ID" value="NSJP_2361"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2361"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="72" mass="8341" checksum="46390AE63AE56D3F" modified="2017-06-07" version="1">MPKEDIIEIQGTVAETLPNAMFRVQLENGHKILAHISGKMRMHFIRILPGDKVTVEMSPYDLTRGRITYRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Y6</accession>
    <name>A0A1W1I6Y6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Fatty acid hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2457"/>
    <dbReference type="EnsemblBacteria" id="SLM48629">
        <property type="protein sequence ID" value="SLM48629"/>
        <property type="gene ID" value="NSJP_2457"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2457"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="2">
        <location>
            <begin position="151"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="345" mass="38599" checksum="D33F2D593784635A" modified="2017-06-07" version="1">MAIDAITWFVERAAEYGLEAVSSWSNVRAALAQIPLAILDLSHPLAWPYLLSSLVIAWILFLAVKRRGETECRSFVEFAFPARLYRHPSTRLDWKFGICDLTLQFLLYTPVMTGMGLLGAKAMTALLVGSWGWEPPHTLSVTGIAAAAVGWFVLHDFVNYCTHVLFHRIPLLWSFHRVHHSAEVLTPAAAFRVHPVELLAFAAIQAPVLGTAAVLYQNILGEEQRITMVFGVSVFTFVSGILGSHLRHSHVWFSYGPVLNRVFMSPAHHQIHHSVDAHHWNKNFAVKLAVWDALFGTLYLPGRREALSVGLPDADRREFTSVSGLYLSPFVRAFQALVPIESRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I716</accession>
    <name>A0A1W1I716_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin synthase catalytic subunit (Modular protein)</fullName>
            <ecNumber evidence="1">2.8.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.8.1.12" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2645"/>
    <dbReference type="EnsemblBacteria" id="SLM48812">
        <property type="protein sequence ID" value="SLM48812"/>
        <property type="gene ID" value="NSJP_2645"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2645"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="231" mass="25766" checksum="270701109D7E9544" modified="2017-06-07" version="1">MITVKLFGMTKSLAGNQSSLSLELPAGRSVKDLVELVNKGYPMIGELIQKKKVLVSVNQEIAHEHTAIGDGDEIALLPPFAGGATESRVDEAQFVRVQREDFSIDAEINRVRSRSTRIGGIALFLGTARDRSKGRDVDGITFEHYEGMAQKKLREIRERAMADFDILELLIVHRYGPITIGENIVLIIAGAEHRADAFRACKWAIDELKQITPIWKLEHTPSGEVWVEEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I732</accession>
    <name>A0A1W1I732_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bifunctional protein FolC: Folylpolyglutamate synthase and Dihydrofolate synthase</fullName>
            <ecNumber evidence="7">6.3.2.12</ecNumber>
            <ecNumber evidence="7">6.3.2.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">folC</name>
        <name evidence="7" type="ORF">NSJP_2650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.12" evidence="7"/>
    <dbReference type="EC" id="6.3.2.17" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2650"/>
    <dbReference type="EnsemblBacteria" id="SLM48817">
        <property type="protein sequence ID" value="SLM48817"/>
        <property type="gene ID" value="NSJP_2650"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2650"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="6">
        <location>
            <begin position="44"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="5">
        <location>
            <begin position="283"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="429" mass="45567" checksum="453623FC55A7FF4F" modified="2017-06-07" version="1">MTYSAAVAYLLGLQKHGIKLGLETMTALARRLGEPQRRYRSLHIGGTNGKGSTAAMVAGILQSAGYRVGLYTSPHLVEFRERIRVDGAMISEDAVARCTAAAQVAAGTDLQPTFFESTTAMAFQYFAEAQVDVAVLEVGLGGRFDATNIVQPEACAITTVALDHQEYLGSTVSAIAFEKAGIVKEAIPLVVGRMTDEAMRTIEGIARERNSPLSALDREFRIEGVVGRFTYVSRRTRYADLRCALPGAHQVDNAACAIAVIEAAGGLQVGERAVRDGVGGVQWEGRLETLEARPDVLLDGAHNPAGAEALAAYLRSAKQARPGSRVIVVVGMMRDKDHKGFMKSLNSVADHIVLTRASIARSATAEELRDELAGMITAPFSVTAGPAEALALARRLAASEDVICVTGSLMLIGEVKASWRGCGLSPLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I739</accession>
    <name>A0A1W1I739_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arsenical resistance operon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arsR</name>
        <name evidence="2" type="ORF">NSJP_2691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2691"/>
    <dbReference type="EnsemblBacteria" id="SLM48858">
        <property type="protein sequence ID" value="SLM48858"/>
        <property type="gene ID" value="NSJP_2691"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2691"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="104" mass="11575" checksum="40E3AA3576ED1F55" modified="2017-06-07" version="1">MPHTGSVNAVSLFHALSDETRLAVLEELKEGERCVCELTEAMKAGQSRLSFHLKVLKEAGLILDRREGRWMYYAINPEAIESLEELVKTLKRAAKSGGAGRRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I755</accession>
    <name>A0A1W1I755_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48868">
        <property type="protein sequence ID" value="SLM48868"/>
        <property type="gene ID" value="NSJP_2701"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2701"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005625">
        <property type="entry name" value="PepSY-ass_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34219">
        <property type="entry name" value="PTHR34219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03929">
        <property type="entry name" value="PepSY_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="420" mass="47721" checksum="A03997CBAF498AC5" modified="2017-06-07" version="1">MNHLMLLMHRWAGLVMAGFLVMSGLTGAVISWDHELDDFLNPHLTHVTSQGPTIPILDLVKTIESRDPRAQVTFIPLAHEAGDSLVFGVDSRVDPQTGRLYELGYNQVFIDPVTGRELGRREWGAVWPVTKETFVSFLYRLHYTLHLPELWGIDRWGIWLMGGIAILWALDCFVGLYLTLPNRMSKETVHAHPSWWMRWKPSWMVKLSGTLRRINFDLHRAFGLWAWGLLFMLAFTAFSLNLYREMFYPLMSLVSEVTPSPFDVREPSDKHHPIVPVVGYESILDRARQEGLQRGWEEPLGEIFYNQEFGIYGVSFFHPGDDHGAAGVGPSALYFDGSDGRYLGDRRPWKGTAADIFVQAQFPMHSGRILGLPGRILVSFLGLGTAVLSVTGVIIWWRKHGAYSRRAQRQADHLNLIPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I760</accession>
    <name>A0A1W1I760_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">clpB</name>
        <name evidence="12" type="ORF">NSJP_2680</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2680"/>
    <dbReference type="EnsemblBacteria" id="SLM48847">
        <property type="protein sequence ID" value="SLM48847"/>
        <property type="gene ID" value="NSJP_2680"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2680"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="11">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="411"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM48847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="871" mass="97336" checksum="997492C9A518B482" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7E1</accession>
    <name>A0A1W1I7E1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Oxidoreductase, GFO/IDH/MOCA family (Modular protein)</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2674"/>
    <dbReference type="EnsemblBacteria" id="SLM48841">
        <property type="protein sequence ID" value="SLM48841"/>
        <property type="gene ID" value="NSJP_2674"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2674"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="120"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="284"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="439" mass="46626" checksum="AF72BA8AC789A0A6" modified="2017-06-07" version="1">MIPAAVQRPKIYYRDRSSGLSMQPGSVPRWGKDQFAIRRAEVCWSRRSARGDLIHPVTVHDDGLRRHTATAFSMSHIGFGARDQSGLARAFRAGRNPPRLNLPSPHAYSLFMSVSNQQIGIGLIGVGRHGRRYLDHLRTDVPGAGVVAVCRKRTGLPATGALAGLSLYADYRELIADPLVQAVVVVTAPALCPEICLAAAAAGKPILIEKPLANSGAEARAMVAAAERAGVLLMTAQTMRFDATVLSAKAQLPAIGRLRLVDLVNHVDSAASIASRSSGTAVPGALLEIGVHLLDLVRFFTGEEVAQVECRLDRPDGAVEAAARAVLHTADGAVCSIDAARVDTGRIGTMQWEGTEGTVTADWVRRTVTCRIGGGRPRQWTVEPAPTIVAVLRAFLYAIRTNTQPPVSGVDGCRAVELADACYRSAALGGTAVSVQEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7E2</accession>
    <name>A0A1W1I7E2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48920">
        <property type="protein sequence ID" value="SLM48920"/>
        <property type="gene ID" value="NSJP_2753"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2753"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="4"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="118" mass="13522" checksum="997B708FD0A3F761" modified="2017-06-07" version="1">MVIRQQPRFPVSFFGTLGYQNRLHQITKSFDLSRKGCRLESPFEAYAGMKVNLLLSLPEGDSPILIEQAVVRWCGVRDMGLEFQSLSSPHRERLDRTLQRFETTVGNEYPCPPSTNTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7H8</accession>
    <name>A0A1W1I7H8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2800"/>
    <dbReference type="EnsemblBacteria" id="SLM48967">
        <property type="protein sequence ID" value="SLM48967"/>
        <property type="gene ID" value="NSJP_2800"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2800"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011986335" evidence="2">
        <location>
            <begin position="21"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="402" mass="43370" checksum="73893EEF376B590F" modified="2017-06-07" version="1">MIWMRSTLLFLFVMSGVVFGDRPVHAAGCDGVVGKWAWFVGGEVTINADGTFTQQSGNSGTWECTDASKGAVALKWKQGGYLNRLALAEGGAKLVSTDPSQSFVKATRMNQEQALADILTRQDTGSPSSSRRPTGQPGGTVPIKPSTPVTQPKAPISYDSPQGLVSSDPKVEARFKQGYDLYMKKSYAAAFPILMETAQAGHPRAQAVLGIIYSQGRGQPVDNKQAAVWYGKAAAQGHRAAQFSLGNLYFEGDGVPKDQVKAVQLYRQSADQGFPHAEFHLGLAYEFGWGGLPRDRRMAIKWLDRASRHKHGQAGWILTWLEDPKTPHFKDVEQLGNYIGGIIDRRAAAAFGSGGGDGGGGNPCSIYSGPAAGACREGNKSAVDRYLDHQETQEDKRKYGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7I2</accession>
    <name>A0A1W1I7I2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48881">
        <property type="protein sequence ID" value="SLM48881"/>
        <property type="gene ID" value="NSJP_2714"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2714"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012709523" evidence="1">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="76" mass="8593" checksum="D58C3B0856872524" modified="2017-06-07" version="1">MRNRHLAVALAGFALAACSTTEWVNANKPPEQYTTDYNKCENSALSDPKLQQGSKILVQTATERCMQREGWRLIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7I8</accession>
    <name>A0A1W1I7I8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AhpC-TSA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2810"/>
    <dbReference type="EnsemblBacteria" id="SLM48977">
        <property type="protein sequence ID" value="SLM48977"/>
        <property type="gene ID" value="NSJP_2810"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2810"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AhpC-TSA" evidence="1">
        <location>
            <begin position="28"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="179" mass="20095" checksum="B05941D8EB16CF4A" modified="2017-06-07" version="1">MGRSGGICFSVRFLMREAYKVEETIRRIGQKALTFRFPAVMGGRMTYLVPEEFRGRWLVLSFVPGLGERESRLWNRQGKVLAELGAVLLLVPSEMRALYWKRLSGIGPLHFAVAGDPLKRLQRLYGGAAELSVGRARTFLVDPEGTLRFHLMHTLTTQGMDVLKELLCAHQDAEFAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7J6</accession>
    <name>A0A1W1I7J6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2851"/>
    <dbReference type="EnsemblBacteria" id="SLM49018">
        <property type="protein sequence ID" value="SLM49018"/>
        <property type="gene ID" value="NSJP_2851"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2851"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025515">
        <property type="entry name" value="DUF4403"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14356">
        <property type="entry name" value="DUF4403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="497" mass="54588" checksum="16101E5449706CAA" modified="2017-06-07" version="1">MTLQENFTDIVRLCRRRKDIACGWPLAVTAAVLMTIVCVQPAGADDYLDIPKPTDRLAPPPAPPNVEPSVLSIPAKVSLQELLVIAADSFPEVMENEGAWHEGPPIAGQPPFQWQYRLHRGPVQVQINNNHLEAVFPDIRYRVAVRAVKPGGEIEDSICGYKPDEPRHMSITVRSNLQWADDWTVRSTTAFDEPVFPDPCASTAAGADVSTIVKAAVHSRLPVLGKKIDERIQEGSQRRRGVEKAWRTLLTPTELAPELWLNLRPGTIQAGPIMGNNEQQVVASLNLLLEPVVTTGSMPPVQERPLPPLQLTSGGQDGFHLAIPVMVDYDWINVRLRRQLVGQEIPMSIGDPIFITSARLYGSGSQLILAMGVRGSVKGTLYAGGKPVIDPVTHILRFDGFDFTMDTRNILVRTANWLLRDNILDTIEPQTRIDLSGQMASMRQALDKALHREVLPGAWINGAVSKLEPKGIYPIEGGVEAQVVADGTIELLLPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Q5</accession>
    <name>A0A1W1I7Q5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48951">
        <property type="protein sequence ID" value="SLM48951"/>
        <property type="gene ID" value="NSJP_2784"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2784"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="45" mass="5209" checksum="29D359C0488BA9A1" modified="2017-06-07" version="1">MRDVTVWAAWYLFLLAVPLFIVASLVREQVVHRRSGRRTGLLKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7R2</accession>
    <name>A0A1W1I7R2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49062">
        <property type="protein sequence ID" value="SLM49062"/>
        <property type="gene ID" value="NSJP_2895"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2895"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="42" mass="4794" checksum="206D1D7E940F3A06" modified="2017-06-07" version="1">MSALVHVKLSLHKWYTPAQQASDLLDHRLTGIDREQRHIASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7R4</accession>
    <name>A0A1W1I7R4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2794"/>
    <dbReference type="EnsemblBacteria" id="SLM48961">
        <property type="protein sequence ID" value="SLM48961"/>
        <property type="gene ID" value="NSJP_2794"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2794"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="287" mass="33257" checksum="486B17A978638269" modified="2017-06-07" version="1">MANRVKTSRILIFVLTSVLLAPVIFTGCATSLLYNHADWLITRQIDGYFDLNRSQRSFVTSRLNGILDGHRREALPQYETVLHEAAMRVQRGLTEADVDWAATEYDRLRADLFGRFSTDGADFIRLVNDRQIPYLKQSLQTRLSKEEGLLHDDRRTRLTKRTERILSLTREWLGNLSPAQEQDISRAAMNLPDILPSWYTHQMERNRQLVELVEARQQGDTPGRLKEWLVNQDKTADPEFRDMLRQFKGRIGELLLTIDRLATPEQRRHVIAKLDDLAKTVHGLSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7U4</accession>
    <name>A0A1W1I7U4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von Willebrand factor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49064">
        <property type="protein sequence ID" value="SLM49064"/>
        <property type="gene ID" value="NSJP_2897"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2897"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01467">
        <property type="entry name" value="vWA_BatA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033881">
        <property type="entry name" value="vWA_BatA_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="95"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="346" mass="38268" checksum="61E14CA6AFE68D87" modified="2017-06-07" version="1">MLIFDVPWVFALLPIPLLVWWLLPPYREASRAVRVPFFEEAAHAAGLTPARGAVVLRTNWAQKLIAPVSWGLLLLAAAGPQWVEPPIERVEAARDLMLAIDLSQSMEAKDFTDREGRRVDRLTAVKTVVDDFIDRRKGDRIGLIVFGSAAFPQAPLTLDHATVRLLLDELRIGMAGPQTSIGDAIGVAIKMTERSKMKERVLILLTDGNDTASKLPPEQAAKIAKQQGVTIHTIGIGNPKAEGEQRVDLHALEQLAQTTGGRSFRGEQRQGLEGIYKTLDEITPEKVKRSLYRPKRALYFYPLCVAALLLVAYHLAMLAWTAIGEKSQIRSTNIEIRNKGNMETGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Y7</accession>
    <name>A0A1W1I7Y7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="8" type="ORF">NSJP_2960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2960"/>
    <dbReference type="EnsemblBacteria" id="SLM49127">
        <property type="protein sequence ID" value="SLM49127"/>
        <property type="gene ID" value="NSJP_2960"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2960"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="332" mass="36830" checksum="189DCF99C84F1C10" modified="2017-06-07" version="1">MVVALGVAAYRVMKWAEEPVVSEQVHPPPKIVTIPDRSTFFQVATLLEHEGLIKSRSAFVLLGRSQSADRRIRAGEYELTAAMAPAEILGKLLSGQVVLHPITIPEGLTMVQIASLMEQHEVADGADFLRLARDGSFIASLGLKLDSLEGYLYPDTYKFPKGVRSRDVIATMVEHFRQAYRPELQARAGDLRMTQHEVVTLASVIEKETGADAERAEISAVFHNRLRKHIPLQSDPTVIYGLTGFDGNIRKKDLSSPSPYNTYRVVGLPPGPIASPGLRAIEAALYPSNSRALYFVSRNDGTHQFSSTLSEHNQAVERYQKRPFRRSALPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I820</accession>
    <name>A0A1W1I820_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48953">
        <property type="protein sequence ID" value="SLM48953"/>
        <property type="gene ID" value="NSJP_2786"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2786"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="119" mass="13477" checksum="76643AF9D07865AD" modified="2017-06-07" version="1">MGPTKAIIKDQALYEASTGKFIKDGFASRHEIDDYVKHHYLALPVIDNAGNAWQLDGKPIYCYRGSQYETVDDRRVHLARCPDCGGMGIRADEFVVESDCIRCTQCGHEFDARLEMMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I867</accession>
    <name>A0A1W1I867_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Big-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49207">
        <property type="protein sequence ID" value="SLM49207"/>
        <property type="gene ID" value="NSJP_3040"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3040"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003344">
        <property type="entry name" value="Big_1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51127">
        <property type="entry name" value="BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010704140" description="Big-1 domain-containing protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Big-1" evidence="2">
        <location>
            <begin position="25"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="501" mass="54157" checksum="882A64D27890101D" modified="2017-06-07" version="1">MPSRMTKAQRTIFAWRVLSFSSVLVLTATTASGLLPESGTVQIIVTDQNGTPISNVNLCLAMPGQSVQKMTDQNGRYTASLPVGSTTVRTSRNGYANAQATVAMTNGANFVRQIFLQTGQATPLPSDCGGFAGTATGGSSGCDRITNLEVVGVPVPGGWKTTKRTISVVAGFSEKPAFYRLTEFSAAERYPESQFNPDVAFAKKNVAWLPITTPVLTLNFTLTEPHYGTHHLYIQTSLALNGCVSHAHGISVVLEPGKLVTYELTGQALDQFIAAAKTRGYRFKAGEFKFNKKDNTYCPNGAMLLPSDPVQDERVSNKVLEDVSASVEEFDGPDLMLYWQLMEIHGSFPGLPTLPARAFAKGTSPAVVYDKYSEPSCPYCGARALKRTLSWRRLVYEFRSPPPKLPALPGDLGRPALPGSYNAVQCITVPDLTRSDQQPSIVKLTLRGPAGDDPVNALGDLRSNTFQAIQPFPPPRIIMPRSIDEETRQDLNEPVAAPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I873</accession>
    <name>A0A1W1I873_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49185">
        <property type="protein sequence ID" value="SLM49185"/>
        <property type="gene ID" value="NSJP_3018"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3018"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="323" mass="35836" checksum="9313F30189052C3D" modified="2017-06-07" version="1">MTKSVPYRDAICALTLTWAIVFWLPLCAFAEEPASPDTAPTISEESPPPAEGADIQERGLLPGLVKPGGTLQLADPKFSAPTPSLTAIRNAMRVTSKSISVNLRIPPNLPVTVPIEVEVFYSSPFRSQILKRTYSSTSGLTLSYRDVEGNGEPRAMKLVITVRELVPNGQVTGINKEFTITPLYDVFVTDLRFYMVDRCDTVGKSDITFKWRSPDRQIHEQKFKLGRGEARGITQFSWTRKEISTRANLMEPSVYFDERDPLGDYTPPIEQSGKALLPGPTTKYHFFLKEETGGPPGRPSPGGGCEAEITYTIIRALMPFDQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8C3</accession>
    <name>A0A1W1I8C3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49272">
        <property type="protein sequence ID" value="SLM49272"/>
        <property type="gene ID" value="NSJP_3105"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3105"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="125" mass="14570" checksum="DC93254F52543CF1" modified="2017-06-07" version="1">MWKRNFMFRASDATPLKESENELFHETDPAMDSAGLQLEKFLSVWIQGDGDDEAPAAYTNMYVRTATLDFQRKVGFLQPLQGRTHQIKQLLTPGQKHFLKEWLSRNAPHAWDSTDDHFKLLFENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8I0</accession>
    <name>A0A1W1I8I0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49327">
        <property type="protein sequence ID" value="SLM49327"/>
        <property type="gene ID" value="NSJP_3160"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3160"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="35" mass="3705" checksum="675B7C77FE11A84B" modified="2017-06-07" version="1">MTQAVIDAMVYWSAAFFLGGFTVGVIVKLLLGGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8I5</accession>
    <name>A0A1W1I8I5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49169">
        <property type="protein sequence ID" value="SLM49169"/>
        <property type="gene ID" value="NSJP_3002"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3002"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="80" mass="8881" checksum="DDD6421671D1519F" modified="2017-06-07" version="1">MRLRALKTSDARGRAASVQADRAITRHADEEEPDQRGRLTSFGDICYKAVTLIPPRRSPPLSSRRLSCRTRTGSGRAEPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8L9</accession>
    <name>A0A1W1I8L9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49209">
        <property type="protein sequence ID" value="SLM49209"/>
        <property type="gene ID" value="NSJP_3042"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3042"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013252505" evidence="2">
        <location>
            <begin position="23"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="340" mass="36448" checksum="7C7256472CAB0A1A" modified="2017-06-07" version="1">MKYIPSCSLALCLLLTSSCGTLLPIDEETCVRSAAMPQKAHITGTKHQYVFQGTCHVARLRIDSPGGQPYFMPIDAPFIAEGYYEPQSKVATEIFRVPEPKISEPSRPWGTFQSSFRCEQDPWLNDVKCEPLTASANPPISAYPGPRYEASRILLNEIFSMIAHFKKPYSAAAVRHSSEGNEAIAKAWAAYRKQEQLAQGARQTPGLSYSAGVAPSILRPAAGQVFLSGNPIPIKLGPPVGWTVTTYMVKLEVKNAQGTWVAHKTIPVGAPQAQSAGGYTGFGVGGFPSSPGNWRISAQISAPNQSGWSNAVEFKVATPPPSGSQSGKAAIGKGSLMRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8T2</accession>
    <name>A0A1W1I8T2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49416">
        <property type="protein sequence ID" value="SLM49416"/>
        <property type="gene ID" value="NSJP_3249"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3249"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="79" mass="9298" checksum="93C26D2A5409C3F4" modified="2017-06-07" version="1">MQYLMRKIRRLAMASSWERRHRLDSRSPLKTCGDKLRENDGEERDMRVNGGYWNLSFGTFRELRTGSRGGEMRGDCKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I947</accession>
    <name>A0A1W1I947_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alkyl hydroperoxide reductase C</fullName>
            <ecNumber evidence="4">1.11.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">prxU</name>
        <name evidence="12" type="ORF">NSJP_3355</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a hydroperoxide + H(+) + NADH = an alcohol + H2O + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:62628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.11.1.26"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.26" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49522">
        <property type="protein sequence ID" value="SLM49522"/>
        <property type="gene ID" value="NSJP_3355"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3355"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102039">
        <property type="term" value="F:alkylhydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017559">
        <property type="entry name" value="AhpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="PTHR10681:SF121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="10">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM49522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="188" mass="20906" checksum="805CA2920ECA53AF" modified="2017-06-07" version="1">MPMIGQLIPDATFTCYHQDQIQEINLQSYRGRWVVLVFYPGDFTFICPTELEDLGTLHAEFQKLDAEVLGVSTDSVYVHKAWRDVSQAVRDLPFPLVADAGGRLARALGIYLPQEGVALRGSFIFDPDGKLCVFEVHHNSVGRNMHELLRKVQAAAFVRENGGVEVCPAGWRPGDRTLKPGLDLVGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I976</accession>
    <name>A0A1W1I976_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3272"/>
    <dbReference type="EnsemblBacteria" id="SLM49439">
        <property type="protein sequence ID" value="SLM49439"/>
        <property type="gene ID" value="NSJP_3272"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3272"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="276" mass="29984" checksum="BFD1239AD68168A5" modified="2017-06-07" version="1">MPRQHISGGGGLRLAVHEFGQPDGRTILLIPGINLCSLAWLKQYQSALAEEFRLVCLDLRGHGMSEKPTASDQYGQPTLWADDIHGVLTTLSLRKPVLVGWSYGGYIINDYLEKYGEGGIGGINYVCAAVVMGRGTGSSMLGSDFINVVPGMCSDDLTANVEAVCKFVRIIFAQQPPQDVLEILIACSMVVPPTARLGMISRNIDRDTVMKGIRVPVLVTTGEKDAVITPAHTKHLLTCISHAEVSVFEGVGHSPQLEDSERFNQELTRFARQYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9J4</accession>
    <name>A0A1W1I9J4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3495"/>
    <dbReference type="EnsemblBacteria" id="SLM49662">
        <property type="protein sequence ID" value="SLM49662"/>
        <property type="gene ID" value="NSJP_3495"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3495"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="161" mass="18064" checksum="D98C100DE6211D30" modified="2017-06-07" version="1">MPLNASIVRADQADAADVAKMVGELLSEIMSTIGEAVFEFDRAGTELRTREWLADRSYAIFLARSSEVGHPMGFVTVYESYGLYAGGRFGTIPEFYVRAGYRSRGIGAELLSEVKRYGEARRWTRLEVTTPPLPQFDRTMKFYTSRGFQLSGGRKLKVDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9N4</accession>
    <name>A0A1W1I9N4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">cobS</name>
        <name evidence="20" type="ORF">NSJP_3533</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3533"/>
    <dbReference type="EnsemblBacteria" id="SLM49700">
        <property type="protein sequence ID" value="SLM49700"/>
        <property type="gene ID" value="NSJP_3533"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3533"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SLM49700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="254" mass="26749" checksum="5C05CA6DC2D43D63" modified="2017-06-07" version="1">MTAGLRSPIIAWQFLTSVPLSRRHHEPSPAELAWSMVWYPFVGIILGAILAVTNVLLMQRLSRDVSAVLCVILLVALTRGLHQDGLADTLDGLAGGRTPADRLAIMKDPCIGALGATGLALSLVLRCTAVAALPDAARLPALLCMPVMGRWAMVVGAWGATHARAEGGLAAPFLAHLSWRQASGATILAAGSLSWAVGLYPAAVMLGVGAMASRLLTWSYRRAFGGITGDTLGTTNELVELCMLVLLPLLWQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9R1</accession>
    <name>A0A1W1I9R1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">gcvH</name>
        <name evidence="6" type="ORF">NSJP_3563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3563"/>
    <dbReference type="EnsemblBacteria" id="SLM49730">
        <property type="protein sequence ID" value="SLM49730"/>
        <property type="gene ID" value="NSJP_3563"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3563"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="128" mass="14042" checksum="EBDCEE095FEAA549" modified="2017-06-07" version="1">MIPPDLRYHKEHEWVRVKETDGTVGISHFAQDALGDIVFVDLPKAGAVVTAGQQIGEVESTKTTSTIYTPVSGTIAKVNADLKDHPELVNSDPYGKGWMIVVHLSNSDEVESLMTSSQYESYLASQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9R4</accession>
    <name>A0A1W1I9R4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49787">
        <property type="protein sequence ID" value="SLM49787"/>
        <property type="gene ID" value="NSJP_3620"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3620"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="277" mass="31530" checksum="491AD41AAEA376AB" modified="2017-06-07" version="1">MSRKLELIREEKLFRLLPGRTKHSRLEASGVALVDDTTALVVFDNLNQVARINLSLKHHATNTLLPAPSLGSGFEDISIDQRHRRVFCQVESVEDFDGLLRGFVAEYDEGARFIRCTRLPSPLTKHNKGFEGLAHMWRGRREYLYALCEAGHNGKGRIEVFVRARDGGWKASHRILLPPKAEFEDYAALAYRDRRLAVVSQASARLWVAQIDEKARAVTPESEAVYRFPSKSYGNVEGIAWLDRHTLVAVSDRKKKRQPGRCSDKDQSIHLFRIPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9U0</accession>
    <name>A0A1W1I9U0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyoxylate reductase</fullName>
            <ecNumber evidence="6">1.1.1.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gyaR</name>
        <name evidence="6" type="ORF">NSJP_3376</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.26" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3376"/>
    <dbReference type="EnsemblBacteria" id="SLM49543">
        <property type="protein sequence ID" value="SLM49543"/>
        <property type="gene ID" value="NSJP_3376"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3376"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047964">
        <property type="term" value="F:glyoxylate reductase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="32"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="113"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="321" mass="34462" checksum="849E26BE84B30525" modified="2017-06-07" version="1">MSESRPLLYVSRLLPEPVMATVRERYQLLTEPEEGPPSPAVLRQGLQEATAAIVTLSERIDAQSLSAASRLKVVANYAVGYNNIDLAAARHHSIVLTNTPDVLTDATADLTWALILATARRVVEGDALVRAGDWTGWSATQLLGAEVAGRTLGIIGMGRIGQAVAHRAVGFRMPVHYYNRGTRLTSPPGAQWAGVSLPDLLRDSDFVSVHVPLTEQTRHLIGASELAAMKQTAILINTARGPIVDEAALVDALERRTIAGAGLDVYEDEPRLHPGLSSLPHVVLLPHLGSATWYARVQMGMICLRNVDAVLAGRPAPNPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9V1</accession>
    <name>A0A1W1I9V1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49827">
        <property type="protein sequence ID" value="SLM49827"/>
        <property type="gene ID" value="NSJP_3660"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3660"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="67" mass="7248" checksum="BD74B2FB7DDE1268" modified="2017-06-07" version="1">MAIIVQGAREAITGKLLREKRLRMEKVLHLLVLSGVIRLAKVEPPLEGLVTLQPPEAPDNVISASAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9X2</accession>
    <name>A0A1W1I9X2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P4Hc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_3681</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3681"/>
    <dbReference type="EnsemblBacteria" id="SLM49848">
        <property type="protein sequence ID" value="SLM49848"/>
        <property type="gene ID" value="NSJP_3681"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3681"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PTHR10869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P4Hc" evidence="4">
        <location>
            <begin position="10"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="189" mass="21827" checksum="73E2CD0F5653710B" modified="2017-06-07" version="1">MVTIEEVDPGKVLLLHDFLTGDECMSLIRRSESLMYEPGKVADVVLEDVRNNERVLLDDMALALDLFHKAKPFLPHELEGHLLVGLNERWRFYRYRPGQTFKPHRDGAYFRVTSFEESQLTFMIYLNEGMTGGETRFFADMEQAFQGCPYLSVKPKTGMALVFLHQIWHEGAVVGSGQKYVLRTDVMYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9X3</accession>
    <name>A0A1W1I9X3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49679">
        <property type="protein sequence ID" value="SLM49679"/>
        <property type="gene ID" value="NSJP_3512"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3512"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="58" mass="6577" checksum="3E6EEA1B5DFEFBAA" modified="2017-06-07" version="1">MPKFPKWEDTIGDLLGLVYRRTGEGPVEDESDDHVVVGTTVKIILTSSKIIWYMLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA36</accession>
    <name>A0A1W1IA36_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Periplasmic chaperone Skp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_3740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Skp family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3740"/>
    <dbReference type="EnsemblBacteria" id="SLM49907">
        <property type="protein sequence ID" value="SLM49907"/>
        <property type="gene ID" value="NSJP_3740"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3740"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35089">
        <property type="entry name" value="PTHR35089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03938">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013162032" evidence="4">
        <location>
            <begin position="31"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="186" mass="20967" checksum="F56725BC5DA99D15" modified="2017-06-07" version="1">MSRPTTLMRQAVLPFCAAALLCLSSVPAGAAEAFKMGVIDPQSVLEKSKAGRRALDGLKEYVSTRQKLLSRDEEELRNTEKTLKESASKFSEAEKKEKETQFRSKIQDYQKRAQEFNQELQGKQKQLVDEYMKKIAAATQTVAEKGGFSLVVDKGSEQTVKIVIYNKDTIDITEQVIKEFDRVNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA79</accession>
    <name>A0A1W1IA79_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49789">
        <property type="protein sequence ID" value="SLM49789"/>
        <property type="gene ID" value="NSJP_3622"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3622"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="55" mass="6229" checksum="0445F17788F701AA" modified="2017-06-07" version="1">MSQHMKTPSEDARQTDALLMPPPTAPASSLIRRLDHDHIQLPIHPRFASLEGRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA87</accession>
    <name>A0A1W1IA87_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49957">
        <property type="protein sequence ID" value="SLM49957"/>
        <property type="gene ID" value="NSJP_3790"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3790"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="314" mass="36448" checksum="3636CBA0AFA65713" modified="2017-06-07" version="1">MPQRIVWPDGKDFAFTIFDDPDCDTVENVAALYSFIGDLGLRTTKAVWPIKGNCTPRIGGTTCEDQPYLRWMQDLQDDGFEIALHNVTYHTSVREETRRGLETFRRLFNHYPNSFANHTGCYEGIYWGRARLSGIQRVIYDLLHLRPNGQSQTFEGHIETSPLFWGDLCKDNIRYVRNFTLDDINTLKACPVMPYHDALRPYVNYWFAASEGRGVDSFTETLCESNQDRLALEGGACIMYTHLASGFFVNGELNSRFKFLLERISRMNGWFVPVRTLLDYVRHVRGSHVITTAERNALERRWLWHKIFHTNGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAB3</accession>
    <name>A0A1W1IAB3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49987">
        <property type="protein sequence ID" value="SLM49987"/>
        <property type="gene ID" value="NSJP_3820"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3820"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="86" mass="9036" checksum="174DB3FBDC21EAE0" modified="2017-06-07" version="1">MTPHRSSYKKTTFLAAAAGTLSLVLSGWLLLMQSIGIPWTGLSFVLHPALAWGSGVPLLGLALYGYAIALGGVLALQNDVKGRAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAD9</accession>
    <name>A0A1W1IAD9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49960">
        <property type="protein sequence ID" value="SLM49960"/>
        <property type="gene ID" value="NSJP_3793"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3793"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="60"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="218" mass="24785" checksum="673CC868741D797E" modified="2017-06-07" version="1">MRQEPSAATFFNGFADTFDTIYDEKRNAFMRWVDCTFRSDMFIRYTLTFDALDNIRGQSIVDIGCGSGPYITEALKRGASLVTGIDPAPNMLTLGRLRVRNSGFADERCILVEDKFPGAPVTPHDHAIVMGVMDYVEDAASFLTALKPVVRRSAVISFPSKHWFRTPFRRVRYRLRRCPVYFYTESDIERLCKAAGFRSVEVRKIPGAGMDYHVCVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAJ4</accession>
    <name>A0A1W1IAJ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50026">
        <property type="protein sequence ID" value="SLM50026"/>
        <property type="gene ID" value="NSJP_3859"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3859"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="42" mass="4560" checksum="DE755DD08217C1ED" modified="2017-06-07" version="1">MPVMEEHSTGDIVIGVVTVLGVLVLIVVFVYVVKQVFSKKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAL2</accession>
    <name>A0A1W1IAL2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49803">
        <property type="protein sequence ID" value="SLM49803"/>
        <property type="gene ID" value="NSJP_3636"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3636"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="100" mass="11456" checksum="93DE750AD8B2E2C3" modified="2017-06-07" version="1">MADKIPKVISSATVIKALAKVFAFQAIEINLLRLHAGISDAKWKALKTEAFKKTYAKQRSFYEDRLMGAFALERISQSERETRLLELWLKQSEDSPKDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAL8</accession>
    <name>A0A1W1IAL8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49919">
        <property type="protein sequence ID" value="SLM49919"/>
        <property type="gene ID" value="NSJP_3752"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3752"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="42" mass="4280" checksum="03146866467DBE35" modified="2017-06-07" version="1">MAAQINQLGAMLAGDIVAWGGAVIGLALTASAVVWVMRLIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAM1</accession>
    <name>A0A1W1IAM1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3875"/>
    <dbReference type="EnsemblBacteria" id="SLM50042">
        <property type="protein sequence ID" value="SLM50042"/>
        <property type="gene ID" value="NSJP_3875"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3875"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00034">
        <property type="entry name" value="HTHCRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="124"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="205" mass="22688" checksum="0B4BC265B711CB3B" modified="2017-06-07" version="1">MLGELSEARYGKDDYIFREGDPTEYFHIVKEGIVKCVKSSPEGKECTLKMLMPGDLFCCDAAAFDGACHPGAAQSMGDVSVLRMKKTAYFELLRRSPDAALEVIKYLGARLNEAQEKAKLLALDRTDQRLAALLLDLAERSGVPDPQGIRLAVRLTRQDMADMIGTTTETAIRIMSRFKKDRLVAGTANRLIIKDLARLKSFASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAT9</accession>
    <name>A0A1W1IAT9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase, sigma-24 subunit, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3943</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50110">
        <property type="protein sequence ID" value="SLM50110"/>
        <property type="gene ID" value="NSJP_3943"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3943"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="118"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="179" mass="20230" checksum="DA247F883AE0D6AC" modified="2017-06-07" version="1">MNDQDLWCLDPVRTSPLGMAFQQYAQELQRFLHRRLGCPDTAADLMQETFLRVAQLPSSTQPDNPRAYLFRIASNLATDAMRRQQVRSAYELGDVETGEIASHAPSQETALEARQQCRLLREAVATLPAKCRIVFLLHKSEHLSYGEIAGRLSISKSAVEKHMSKALAHCRDYMDRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAW0</accession>
    <name>A0A1W1IAW0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50136">
        <property type="protein sequence ID" value="SLM50136"/>
        <property type="gene ID" value="NSJP_3969"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3969"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="281" mass="30287" checksum="DD99090693EC3978" modified="2017-06-07" version="1">MSFSERMLKIDRRIIFLLIGLCTLLPLLYPVGLPIKISPEVRGVYDHMESLPPRSVFLLSIDFDPASKPELHPQAIALLRHAFRKDLRVVAMTLWVSGTGMAEQLVSQVAQEAGKENGKDYVFLGWSPGGSAVIINMGQDLYTAFPSDYGGRATKGLPVLDGVHSLKDVTYAISLGAGVPGVEAWYVFGKDKYKFELGGGCTGVMAPGLYPLLRSGQINGLIGGLRGAAEYESLIGQKGRAVAGMDAQSATHMAIIVLVVICNLFYFTLRRQGGLQSPGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAZ6</accession>
    <name>A0A1W1IAZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_4005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4005"/>
    <dbReference type="EnsemblBacteria" id="SLM50172">
        <property type="protein sequence ID" value="SLM50172"/>
        <property type="gene ID" value="NSJP_4005"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4005"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="330" mass="36483" checksum="72BBCA8F026BCB07" modified="2017-06-07" version="1">MLGFGGKPRFCLKVGSRGLVWGEHIRTWRGRHRYRCHSSPLPADSIKLSPIDPNVINHAVLEERLRSLVSSGSRSRLTEKIGMSELPKAITLVLPDLAVRTIVLSLDHLPSRSEELEALIRWRLGQEQRLPLVGTKLVWQVFPASGADDNSHVVLVVVIQDSILHQYEAVCEAAGLVPREVGVTSFSSFNLWLRAAGGRRRLHHDLAWVTVLDGALTCFIFHDRRPVFVRTKLLPEDPVHSAQAGGNVEDRVLREISASFLACQEQHPQVQAKEIILMATDSCQHWGAALNRELGVTVESVTWNHIDSLGWKTGGGTASLEALPVVAGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB50</accession>
    <name>A0A1W1IB50_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50141">
        <property type="protein sequence ID" value="SLM50141"/>
        <property type="gene ID" value="NSJP_3974"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3974"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="123" mass="13837" checksum="FC9721D04115BC07" modified="2017-06-07" version="1">MRSLSKEHLAKRLRELRTGLQHAFAVQPEEPLLSLDDLQLMERMADAVVRRGMAAPTTVFLESMGPMNFLGSQALHFLTPIVECAFDPKEVEQIARLLERRDSLSRLITLIDAKSAAKRVPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB52</accession>
    <name>A0A1W1IB52_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4053"/>
    <dbReference type="EnsemblBacteria" id="SLM50220">
        <property type="protein sequence ID" value="SLM50220"/>
        <property type="gene ID" value="NSJP_4053"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4053"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="337" mass="38053" checksum="CE1EA6A08615BF7B" modified="2017-06-07" version="1">MEPLVSVIVSAYNLGWCIQDTIRAVLAQTYRNIEIIVVDDASTDDTSDRVKPFLDQITYIRHETNQGLANNAEGGPARNTGIRIARGEYLAFLDGDDLWEPEKIAVQVETARRFPHAGLIAVDGVSFNHENGRILGTSLFHDQGDSLCGAMEEGEALEADIYRRTLRGCMIDTPSQVMIPASAISVVGPFSLCRSDDYDFYVRLTEKFKAVLVKKPLVRYRCHTSSISGPLQMQFFRFVQSGLAARKRHLLVCSEEVKPFLKQQIRNKLRIASERTREEGDRGQKIWASRFLWGLVTNNPTSPGVEYVWLSLARLWCPESVATIVRPLTTRILRHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB92</accession>
    <name>A0A1W1IB92_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tmk</name>
        <name evidence="5" type="ORF">NSJP_4093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4093"/>
    <dbReference type="EnsemblBacteria" id="SLM50260">
        <property type="protein sequence ID" value="SLM50260"/>
        <property type="gene ID" value="NSJP_4093"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4093"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="4">
        <location>
            <begin position="15"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM50260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="227" mass="25258" checksum="5C36E1F016E28DD8" modified="2017-06-07" version="1">MKARTWIHRGLFITLEGPEGSGKTTQIRYLATALRKAGCRVVTTREPGGTPIAEAIRTVLLLSKRKEPISVQAEALLILAARSQHVTQVIKPALKRGAVVLCDRFSDSTMAYQGFGRGLDREWLAQANAVAADGLQPDLTILLDLPVAIGLARRRAARGQQNRLDRETTRFHRRVRRGFLALAEQARGRITVIHADRCVEDIRAEIEPLALRWAARYVGYRRGVHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZN6</accession>
    <name>A0A1W1HZN6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiamine-phosphate synthase</fullName>
            <shortName evidence="8">TP synthase</shortName>
            <shortName evidence="8">TPS</shortName>
            <ecNumber evidence="8">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="8">TMP pyrophosphorylase</shortName>
            <shortName evidence="8">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">thiE</name>
        <name evidence="11" type="ORF">NSJP_0048</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 8 9">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8 9">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0048"/>
    <dbReference type="EnsemblBacteria" id="SLM46220">
        <property type="protein sequence ID" value="SLM46220"/>
        <property type="gene ID" value="NSJP_0048"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0048"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="10">
        <location>
            <begin position="8"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM46220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="208" mass="22047" checksum="52914CF9223577FD" modified="2017-06-07" version="1">MPRFDSRLLLVTDRQQTGGRPLRSVVEQALRGGVTAVQVRERDLSTRALLALARELRALADPAGCRLLINDRVDLALATEHTGVHLRSDSLPVAVARRLVGPDRVVGVSAHSGEEVLRAESEGADYVVFGPIYATPSKVSFGPPLGLHELEKICARVRIPVLGIGGVTAERAREVRGAGAFGVAVIAAILSAPDVERAARELIDAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I040</accession>
    <name>A0A1W1I040_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, family 2</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46342">
        <property type="protein sequence ID" value="SLM46342"/>
        <property type="gene ID" value="NSJP_0170"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0170"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="262" mass="28826" checksum="7FE8C2E41E0DB6EF" modified="2017-06-07" version="1">MHHSIIIPAYNEAGRILPYLRRITDYMRGRGNPYEILVVDDGSTDATPSVVDGLSACIPEISLLRLPGRRGKGAAVKRGMQAATGQLQLFADADGATPIEELARLEQALETGAHLAIGSRALASRLPEFSVRAKLYRTILGGLFNAAVRQGGIRNISDTQCGFKLFRRTVAQDLFGVATIEGYGLDLELLYVAQRRGYRIAEVPINWTDQPGSKVRVWRDGLLMMRELARVRQNDRKGLYHTAAFAESLAANPSRRLGLPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I065</accession>
    <name>A0A1W1I065_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">dnaJ</name>
        <name evidence="3" type="ORF">NSJP_0223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0223"/>
    <dbReference type="EnsemblBacteria" id="SLM46395">
        <property type="protein sequence ID" value="SLM46395"/>
        <property type="gene ID" value="NSJP_0223"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0223"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="342" mass="37229" checksum="EB1CE4B3B5144D6A" modified="2017-06-07" version="1">MATTARDYYQILGIARSASADDIKKAFRRLARQYHPDLHTGAKKADMEKKFKELNEAHEVLSDPDKRKKYDQYGAQWEQAEAFEKARQQSGARGFGGQESGGGFSGEGFSDIFENIFGGRTRGGGGRGFAMSGEDLETEVELTLREVLTGVTKRISLREPSTCPVCQGSGEFRGRTCPTCEGTGVKTESKTIEVKIPAGVQDGTRVRVAGKGQPGMNGGKRGDLYLHVVIPPDPIFRRQGSDVHVALPVYAWEAVLGAEVMAPTLTEPVKVKVPPGSRAEGKLRLKGKGLPSAAGGHGDLFLTLQIVMPASVTDEEQSLYERLAKMRHPDPRAELLTQARMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0E6</accession>
    <name>A0A1W1I0E6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46480">
        <property type="protein sequence ID" value="SLM46480"/>
        <property type="gene ID" value="NSJP_0308"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0308"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="74" mass="8269" checksum="50D755707BE92087" modified="2017-06-07" version="1">MSDPISLSKARQSASPETWLGAETHVPNLSRELRRRERFSWQLATPVIALALLVSGALIGSAATWLIFRARRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0K5</accession>
    <name>A0A1W1I0K5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0358"/>
    <dbReference type="EnsemblBacteria" id="SLM46530">
        <property type="protein sequence ID" value="SLM46530"/>
        <property type="gene ID" value="NSJP_0358"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0358"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="677" mass="73188" checksum="6ECB3FB763423594" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Q7</accession>
    <name>A0A1W1I0Q7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0413"/>
    <dbReference type="EnsemblBacteria" id="SLM46585">
        <property type="protein sequence ID" value="SLM46585"/>
        <property type="gene ID" value="NSJP_0413"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0413"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="815"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1003" mass="110230" checksum="CBDF73DB4829F6D9" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Q8</accession>
    <name>A0A1W1I0Q8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gly-zipper_OmpA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0416"/>
    <dbReference type="EnsemblBacteria" id="SLM46588">
        <property type="protein sequence ID" value="SLM46588"/>
        <property type="gene ID" value="NSJP_0416"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0416"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025693">
        <property type="entry name" value="Gly-zipper_OmpA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13436">
        <property type="entry name" value="Gly-zipper_OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gly-zipper_OmpA" evidence="1">
        <location>
            <begin position="67"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="141" mass="13893" checksum="FB3951C24AB11780" modified="2017-06-07" version="1">MRIRGTIVAMSVGALVACAGPKPVLYPNAHLQSVGSETAEADIKDCRQMAESAGAEQATGGKAGGVAKSTAMGAGIGAASGAVGGAITGSPGLGAAIGAASGATWGFLVGLFTSKSKDNPAYTNFVNRCLQEKGYEVTGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0V1</accession>
    <name>A0A1W1I0V1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46473">
        <property type="protein sequence ID" value="SLM46473"/>
        <property type="gene ID" value="NSJP_0301"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0301"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="81" mass="9549" checksum="E591292C2FC03235" modified="2017-06-07" version="1">MGFANYVSIWLRSVDCHMLLERRLLMRVQFLIHRHALDSTLCESNSHRAGIAMLRKLTERLLGPLHRRLHISHHPPPYEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Y4</accession>
    <name>A0A1W1I0Y4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0475"/>
    <dbReference type="EnsemblBacteria" id="SLM46647">
        <property type="protein sequence ID" value="SLM46647"/>
        <property type="gene ID" value="NSJP_0475"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0475"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="4"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="307" mass="34057" checksum="BFCC05155545B30D" modified="2017-06-07" version="1">MKVLVTGGAGFIGSHIVDRLVQEGHDVVVVDNLSSGKRRNLNRAARFYKTDIQSWRLERVFRNERPNVVLHLAAQMDVRKSVEDPLFDAQVNVLGTLNILQQTVKHGVRKVVFSSSGGAIYGEQDVFPAPESHATMPLSPYGLSKLCGEQYLSYYERVGGVQVVNLRYANVYGPRQDPEGEAGVVAIFIQKLLNNEQPVINGNGRQTRDFVFVEDVVEANLAVMGQETAGTYNVGTGVETSVNDLFRILVQHTGSTCKELHGPAKKGEQARSVIDATKLRHELSWEPKMSLSDGLKRTVEYFKQRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Y5</accession>
    <name>A0A1W1I0Y5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0480"/>
    <dbReference type="EnsemblBacteria" id="SLM46652">
        <property type="protein sequence ID" value="SLM46652"/>
        <property type="gene ID" value="NSJP_0480"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0480"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005235">
        <property type="entry name" value="YmdB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36303">
        <property type="entry name" value="PTHR36303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13277">
        <property type="entry name" value="YmdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004789">
        <property type="entry name" value="DR1281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00282">
        <property type="entry name" value="TIGR00282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR004789-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004789-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="259" mass="28156" checksum="C5662EBB2B891D91" modified="2017-06-07" version="1">MKILYIGDIMGEPGRRAVARMVPRLVAQRRIDVVIGNGENVAGGFGITPDLAEELFQAGLSAITTGNHAWDKREILDYFPRERRLLRPANYPEGVPGQGSVVVQTSGGEELGILQLMGRAYMPTLDCPFQVAKREMAKLRKRVAAVVVDMHAEATSEKMAMGHFLDGEATAVVGTHTHVQTADEQILPRGTAYLTDIGMTGPLHGVIGVKKELAIEKFLTGMPRRFEVASGPVVFCAALIDVDARIGKALSIERIRILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I139</accession>
    <name>A0A1W1I139_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 2-oxoisovalerate dehydrogenase, alpha subunit (TPP-binding module)</fullName>
            <ecNumber evidence="4">1.2.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0543"/>
    <dbReference type="EnsemblBacteria" id="SLM46715">
        <property type="protein sequence ID" value="SLM46715"/>
        <property type="gene ID" value="NSJP_0543"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0543"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="3">
        <location>
            <begin position="23"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="333" mass="36823" checksum="80E1DB9593838CC5" modified="2017-06-07" version="1">MDLEMVRQHIKRADLLQMYYYLRLTRSLEDRITALYRQGHIAGGCYTSHGMEAIAVGYASAIERDDVIAPFHRDMGAFLIRGITPGEVLAQYLGKRTGPTKGKDGNVHMGDLKRGVIGFVSHLADNLPVAAGAALAFKIRGERRVVVAGTGDGGTSRGDFHEAMNFAAVRKLPVVFFCNNNQYAYSTPQNIQMAIQDVADRAKAYGMPGEIVDGNDVSAVYLASKRGVAKARAGDGPTFLEFKTMRMHGHSEHDSAKYVPRELLEEWKKKDPILKAEHLLARLGYGDEGYFQEISERTKKEVDTGLEFAEHSPLPEGREVLEGVFATEEEVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I166</accession>
    <name>A0A1W1I166_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FeS cluster assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">iscA</name>
        <name evidence="2" type="ORF">NSJP_0573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0573"/>
    <dbReference type="EnsemblBacteria" id="SLM46745">
        <property type="protein sequence ID" value="SLM46745"/>
        <property type="gene ID" value="NSJP_0573"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0573"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
        <location>
            <begin position="12"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="117" mass="12567" checksum="02E35999A4EC9956" modified="2017-06-07" version="1">MDQDTATQTPVITLTEAALKEVKRLINVQGLTEGGLRLGVKGGGCSGLSYTINFDEKIGQYDQVYDFDGVKVIVDAKSAIYLQGTQLDYQKDLMGGSFKFVNPNANKTCGCGESFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1B0</accession>
    <name>A0A1W1I1B0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46788">
        <property type="protein sequence ID" value="SLM46788"/>
        <property type="gene ID" value="NSJP_0616"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0616"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="267" mass="29340" checksum="6757C270F895DE98" modified="2017-06-07" version="1">MTLTQNRFIGDPAGLALLRIALILIVMLTAGCSSSGYGWHVRTNSSPPSPTFNRAVFTQGSVAIFGALAPPRLLGSETGLDTILAQVLKTVAPSLKVITQQEVASLINRNDLANEYARMRNEALQSHLLDGGTLKKLGTAIGTRYVFQPKLIEFMQIMKDRWEMPPIALKVSRIRSSIMRLSLQLWDMQTGELLWASTAEASLESEAVGQDPIYFEDDARVTMGSMLADFTSGQTTSSYGPLNGLIDQLIQFPQPEKHKNTDNTEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1D9</accession>
    <name>A0A1W1I1D9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46801">
        <property type="protein sequence ID" value="SLM46801"/>
        <property type="gene ID" value="NSJP_0629"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0629"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="57" mass="6409" checksum="8E2B16A149508438" modified="2017-06-07" version="1">MNLPLLTLRFRKVARHEYPKGQLGEIEASQAHCVRREAIDGVIGGVRRAEGNREPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1G1</accession>
    <name>A0A1W1I1G1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0655"/>
    <dbReference type="EnsemblBacteria" id="SLM46827">
        <property type="protein sequence ID" value="SLM46827"/>
        <property type="gene ID" value="NSJP_0655"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0655"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="11"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="162" mass="17776" checksum="71EF1A4D1D07972A" modified="2017-06-07" version="1">MASQVRPIPEGYHTVSPHLAIRGGLEAMEFYKKAFGAEERGRFMTPDGKQLMHGEVKIGDSIVMLGEENPQRGCPGPQSIGGTTVGLFLYVQDADRVFNQAIAAGAKSIMPVADMFWGDRAGTVADPFGHQWTIATHKEDVPPEELKKRGQAFFEQMARQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Q5</accession>
    <name>A0A1W1I1Q5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="11">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="11">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="11">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">nnr</name>
        <name evidence="9" type="synonym">nnrD</name>
        <name evidence="10" type="synonym">nnrE</name>
        <name evidence="13" type="ORF">NSJP_0753</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 11">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10 11">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 9 11">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 9 11">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10 11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 11">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="11"/>
    <dbReference type="EC" id="5.1.99.6" evidence="11"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0753"/>
    <dbReference type="EnsemblBacteria" id="SLM46925">
        <property type="protein sequence ID" value="SLM46925"/>
        <property type="gene ID" value="NSJP_0753"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0753"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
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    <sequence length="516" mass="53245" checksum="4F7D0F67F15264DD" modified="2017-06-07" version="1"> </sequence>
</entry>
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                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="491" mass="54013" checksum="9624475742D0407B" modified="2017-06-07" version="1">MALEILGSRLLAPVFGNSLFVWGALIGVILAAMSSGYAFGGWMSDRYPGARVLACLLLFSGSWTFLIAWLSQPVLFRVAAAIEDPRWGPCAAAGLLLAPPAFGLSGVLPAMLRLAVSDLNHLGRHTGRMIALSTVGSLAGTWGTAFFFLSWIGSHALVGWLGAIQVGLGFWWLLKGTAPRALVVAALVLGMSGLGVGAINPVEMLKAPVYQEDSPYQQVRIRDDELFRYLILDRTFHAVMWKAEPITLFLPYSQLMVSSLAWVPEPKRGLIFGHGGGSFAKWLAHRWPELELDVVEFDPVVVRIAEEFFSYQAPSHHHVYARDARVFLNGTKESYDLIWVDAFARHMIPFHLTTKEFFSELRAHLKPDGVLAVNLASSGEGGDLLRASAVVQTMKESFSTIQTYAVKGPWPSLKKAENLIFFAGLAIESQPPEDLAIKVTAMVEHQRLPPESIALLSTRRTEPWKPGEILTDDYAPYDLLIGSNVRESRSE</sequence>
</entry>
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    <accession>A0A1W1I1R9</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">NSJP_0637</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46809.1"/>
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        <property type="component" value="Chromosome i"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="46" mass="5242" checksum="90689B2AB085CA60" modified="2017-06-07" version="1">MQALTELLKPGGKAMQHAESSIDALMLRKWEHEWDASLKVHVERIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I208</accession>
    <name>A0A1W1I208_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0874</name>
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        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47046.1"/>
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        <property type="component" value="Chromosome i"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="151" mass="16440" checksum="F13B3ECA5E1B6325" modified="2017-06-07" version="1">MPETIPQSSPSAFGEAGRSIHHPASAPLSQAPGQFAAHDSGVILLSAPTRILHMNGRARALMALFGDVHGLWPNLAPDSIPIILVEFCGEILMELDRRAQGGEWEQFEMRRVCHMTTPPLMLRGFGVPVSADREPRMILLLQPHSSWSSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I218</accession>
    <name>A0A1W1I218_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_0691</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0691"/>
    <dbReference type="EnsemblBacteria" id="SLM46863">
        <property type="protein sequence ID" value="SLM46863"/>
        <property type="gene ID" value="NSJP_0691"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0691"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="228"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="422" mass="44145" checksum="0C78808010A70955" modified="2017-06-07" version="1">MPTEKIRPPSRQSLRALDALNVLLADVRDGVGPYLAIYLLTAQQWDPASVGVAMSAMGISSVLAQTPCGMLIDALKQKRLLIALAALFVGAGCAALTRVSTFDFVIAVQALNGVAAAIFPPAVAAITLGLVGPKRFAVRTGRNEAFNHAGNVGAAALAGAAGHFLGLQWIFFLVSGIAVASVISVWFIREEDIDHDLARGAVPHVSPEQGDGQAGLFSGFRALLHNRILLIFALSTTLFHFANAAMLPLAGQLLSRHDEAGAPLYMTACIIAAQIVMIPVAAAAGILAERWGRKPVLCIGFAALPIRGFLYTLSDDSWFIVVVQLLDGIGAGVLGVLWVTVVADLTQGSGNYNLALGAIATAQGIGAAFSHLTAGYVVNGWGYQTGFVVLAVIAGFALALLLRAMPETGWSHEMEDTRLAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I296</accession>
    <name>A0A1W1I296_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NSJP_0956</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the kinesin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0956"/>
    <dbReference type="EnsemblBacteria" id="SLM47128">
        <property type="protein sequence ID" value="SLM47128"/>
        <property type="gene ID" value="NSJP_0956"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0956"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002151">
        <property type="entry name" value="Kinesin_light"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011717">
        <property type="entry name" value="TPR-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07721">
        <property type="entry name" value="TPR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012235633" evidence="9">
        <location>
            <begin position="21"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="223" mass="24661" checksum="F7D4FC4454C1127A" modified="2017-06-07" version="1">MRFVLLAAFLVCGLVACQQATWESTMAAAQHAVQQGNYAEAERLLLVAVRKAEEFGLHDRRVAVSLSQLAQVYAGQGKHVEAEPVYLQALKIYQEVHGEDHPDVAATLNNLGVLHRMYGQYAEADPLLTRALLIKERLLGPEHPDVALGVANLAQLRVAQGQPERAEPLYRRALNIREKTLGPSHPEVAKTLDDLANVLKKLGRREEAVSLEVRARELRAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2C5</accession>
    <name>A0A1W1I2C5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Peptidase U62, TldE-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47147">
        <property type="protein sequence ID" value="SLM47147"/>
        <property type="gene ID" value="NSJP_0975"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0975"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="228"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="446" mass="48846" checksum="9D5DA37F6547E014" modified="2017-06-07" version="1">MSLTDKSWPRMTGREEFRFLADLVFRRSAGDATIVVLHDHHGGTTRFANSQVIQNVDTRRGTLTVTVSLDGRSGTASTTDFTAGAINNVVAKAEQTARLSPKDPEYLPPPEQTTFPHRDTARPETAAAGPARRLEYANEAIGQCRIENLLAAGIVSSAHASAGIAASNGLFAFEERTESRFGVTVQAGEATGWSAAAHRSLDHLRIQERTLTAIGKAKRGREFRELPPGRYPVILEPAAVAGLLSWVLWMLDARDYDKGTSPFTGKLGRRVFSERLTLRNLPDHGDLLGVGFTSEGLPSETSTWVDNGTLQQLSYDRFTALRHGIAVIPTMEAPYLSDSKPAAAKVQDLIKQADRAILVTNFWYIRVANPSDLTLTGMTRDGTFLVEDGQIVAPVKNFRFHESPLRAFAQLESCTEPAEAVTSETNKALVPAMMIREFNFSSVTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2F9</accession>
    <name>A0A1W1I2F9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47188">
        <property type="protein sequence ID" value="SLM47188"/>
        <property type="gene ID" value="NSJP_1016"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1016"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="230" mass="23467" checksum="06E49A54D0082A9D" modified="2017-06-07" version="1">MPTSLSGKVVLIAGGGGALGGTIVPAFVRSGARVISADRNPPPEQVIEGKAMKADVADKAAVHRLLEDVIRTAGRLDVLVNLVGGFAAGRIADTDVSLWHRMLAVNLTPAFLLSKAALPHMTARGSGRLLHVAAWAAVEPFDGAGAYIVAKSGLLALIRVLALELKGSGVTVNGVLPTTIDTPANRANMPEANPSSWTKPESIAELLTFLASDGAGQISGAAIPIGAHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2G5</accession>
    <name>A0A1W1I2G5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47013">
        <property type="protein sequence ID" value="SLM47013"/>
        <property type="gene ID" value="NSJP_0841"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0841"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="258" mass="29006" checksum="A5A469056220B140" modified="2017-06-07" version="1">MCRGCVERKVLGEWRGAGNDSAAQAGEEEKRDVPFTAHCTARVPVFEESTVCKARIYSIPVLVVCRVGWFDVNYDHIRNGRKLEGIGGQDLKQIRRDAQHEHTQEHRDFQPTVGHESGLDQSHRLNLAESGCSVWKMGQVDGDGTVYPIFLKTMGIPICQVRDRSANWSRVFDTNWPLLHKLACTYRSESLRDVVFTGTAPSTSRQSASCVCGCSAWLYKGGVGGRGGWKWLCPPRQHITVWIRDPMRGADRSRSHFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2S8</accession>
    <name>A0A1W1I2S8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47310">
        <property type="protein sequence ID" value="SLM47310"/>
        <property type="gene ID" value="NSJP_1138"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1138"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="90" mass="9913" checksum="40EED18ED72D0F24" modified="2017-06-07" version="1">MDQSASSVSVISPAVSSMASVTTRLKSDITDRIFETVRRTQVCEMEDLVQACSSYTWNQVFLEVDRLSRTGELRLLPKQGGIYAVTLPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2V7</accession>
    <name>A0A1W1I2V7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1168"/>
    <dbReference type="EnsemblBacteria" id="SLM47340">
        <property type="protein sequence ID" value="SLM47340"/>
        <property type="gene ID" value="NSJP_1168"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1168"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039498">
        <property type="entry name" value="NTP_transf_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14907">
        <property type="entry name" value="NTP_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="268" mass="31042" checksum="DC4164D2B68A1EE1" modified="2017-06-07" version="1">MQSNGMLEDRAHDVYRQALATLEACGVPFLVGGAFALESYTGLVRRTKDLDLFVRSADRHRLMDALGRAGFQTEWRFTHWLGKAWQGEYSVDVIFNSGNGLCVVDDLWFEHAMPSVVLGHSVKVVPAEEMLWSKAFVMERHRYDGGDIAHLLRARVHLMDWARLLRRFNVHWRVLFSHVLLFGYIYPAHRLRVPEWFMQEMLRRITLDMQSLPSDPRVCQGTLLSWSQYLVDMDPGGYEDARHPPRGSLTWAETRHMTQVLTQEMNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I320</accession>
    <name>A0A1W1I320_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47406">
        <property type="protein sequence ID" value="SLM47406"/>
        <property type="gene ID" value="NSJP_1234"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1234"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="64" mass="7207" checksum="78D67D17C32AAA09" modified="2017-06-07" version="1">MPKDKEKEPEEPGIWHFREVPREAIVKAKIGAALEGLSVKAYIIKLVEAHWKDLEKGGSIPKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3D8</accession>
    <name>A0A1W1I3D8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative RNA polymerase-binding protein DksA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_1346</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1346"/>
    <dbReference type="EnsemblBacteria" id="SLM47518">
        <property type="protein sequence ID" value="SLM47518"/>
        <property type="gene ID" value="NSJP_1346"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1346"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="6">
        <location>
            <begin position="66"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="145" mass="16558" checksum="54BF1FC9680250A3" modified="2017-06-07" version="1">MKARSPVRRTSGPSVKPSVRKRRAQSSAGAGKYSSIRKELQKQRAAILEEAGEGLSKRDGQEAFPDVSDQASAEVDQNFTMRIKEREQKLLKKIDEALDRMKKSTYGICERCEEEIPYQRLKARPVTTLCIACKTLQEQEERTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3F3</accession>
    <name>A0A1W1I3F3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein CusR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cusR</name>
        <name evidence="5" type="ORF">NSJP_1358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1358"/>
    <dbReference type="EnsemblBacteria" id="SLM47530">
        <property type="protein sequence ID" value="SLM47530"/>
        <property type="gene ID" value="NSJP_1358"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1358"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="223" mass="25192" checksum="A247BA26AB480417" modified="2017-06-07" version="1">MRILVIEDETKVGCFIKRALEEESYAVDLCEDGAKGLEMALGTSYDTIVVDLMLPSLSGLDILRAVRRERIQTPILILTAQSQVDQRVKGLDAGADDYLTKPFAIDELLARIRALLRRGATDSPGVLQIDDLVLNPATREVTRGGQRIDLTLKEYALLEYLMRHGGRVLTRPMISEHVWNQDFDTFTNVIDVYVNYLRNKIDRGRTKKLIHTIRGSGYMLKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3I2</accession>
    <name>A0A1W1I3I2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1380"/>
    <dbReference type="EnsemblBacteria" id="SLM47552">
        <property type="protein sequence ID" value="SLM47552"/>
        <property type="gene ID" value="NSJP_1380"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1380"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007462">
        <property type="entry name" value="COV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31876">
        <property type="entry name" value="PTHR31876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04367">
        <property type="entry name" value="DUF502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="204" mass="22878" checksum="F63990CB2EED9697" modified="2017-06-07" version="1">MNVWWRYSLAGLLILVPAWITFLILSALIATVNRLIRELMQNLGFSETPLMGLILFCLLVLLTGALATRMLGRQLLTKGERWIESLPIVRSIYLTLKGMTDLFQFRSRFGRSTVVAFPFPRDGLWALGFVMGVAPAAVQVDPSVTLTMVFVPTAIHPFTGYLAFIPEYKLRHLNLLPEEAMKMEFSAGFYKPAAGWSNVPRSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3K2</accession>
    <name>A0A1W1I3K2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47545">
        <property type="protein sequence ID" value="SLM47545"/>
        <property type="gene ID" value="NSJP_1373"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1373"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="75" mass="8905" checksum="97CD23F438B8D1E1" modified="2017-06-07" version="1">MNEYQIGGGLRLLTAVEKTGAFGEFLRTRMVRALETEDPTELHYLLAQLDDYYHYMWRYYKKLAKDRAERMNPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3N7</accession>
    <name>A0A1W1I3N7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tatA</name>
        <name evidence="9" type="ORF">NSJP_1327</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a complex with TatC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1327"/>
    <dbReference type="EnsemblBacteria" id="SLM47499">
        <property type="protein sequence ID" value="SLM47499"/>
        <property type="gene ID" value="NSJP_1327"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1327"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="45"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="264" mass="27285" checksum="4DF844BDCF13AE73" modified="2017-06-07" version="1">MFGTMGISELIIILVIVLIIFGAGKLPQIGEGVGKALKGFKKEVHDIPPPEATLSDQAPPPPVQADGPPVQAPANPQVVSPQPKPTAPYTPGPELTPGTTAAAMYNMGPQVHSTAPKSSSPASGANVGQGPPSMEERAATPAPVMRAQYPPLPPTAQQKPVAAKRPSAVVNKDAVARVQAQQAAMKAKAAQPAGVSPADMQSLGEGLGDALRTFKQAVADVRNSVDPEMRTIQAEMDAAQKELQQSIESAKELPAVQEDPSKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3R8</accession>
    <name>A0A1W1I3R8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OmpA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_1311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1311"/>
    <dbReference type="EnsemblBacteria" id="SLM47483">
        <property type="protein sequence ID" value="SLM47483"/>
        <property type="gene ID" value="NSJP_1311"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1311"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010717142" description="OmpA-like domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="304"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="446"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="515" mass="55492" checksum="DFF838C74D929E65" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3S2</accession>
    <name>A0A1W1I3S2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47644">
        <property type="protein sequence ID" value="SLM47644"/>
        <property type="gene ID" value="NSJP_1472"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1472"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="58" mass="6409" checksum="E93336C501214993" modified="2017-06-07" version="1">MLSPVLLLDVRPTHEARVEGDYACLEISPNTEKKLTESTTRFFVSSTFGPRALLRSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3T1</accession>
    <name>A0A1W1I3T1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47677">
        <property type="protein sequence ID" value="SLM47677"/>
        <property type="gene ID" value="NSJP_1505"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1505"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="97" mass="10876" checksum="A27174A83C0DD1C5" modified="2017-06-07" version="1">MYSTGMIAGTTQTKRRGLRTETSLIATCCVCGLLRSKKTHSQDPDRWVTRRAYEQTYGVSLVGSPFTHTYCSGCHADFMQRAKPEKHNLMPATPYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3T9</accession>
    <name>A0A1W1I3T9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hemoglobin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1492"/>
    <dbReference type="EnsemblBacteria" id="SLM47664">
        <property type="protein sequence ID" value="SLM47664"/>
        <property type="gene ID" value="NSJP_1492"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1492"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="54" mass="5876" checksum="012DE4CE856A6D5A" modified="2017-06-07" version="1">MKTTHAGMKISEAEFGALIGDLVKALTSFNAPSREQQELLAVLGPMKKDIVEYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I482</accession>
    <name>A0A1W1I482_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">uvrC</name>
        <name evidence="10" type="ORF">NSJP_1613</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1613"/>
    <dbReference type="EnsemblBacteria" id="SLM47785">
        <property type="protein sequence ID" value="SLM47785"/>
        <property type="gene ID" value="NSJP_1613"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1613"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="8">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="9">
        <location>
            <begin position="256"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="604" mass="67552" checksum="9A72A81025BBB51B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4A0</accession>
    <name>A0A1W1I4A0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Crystall_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47771">
        <property type="protein sequence ID" value="SLM47771"/>
        <property type="gene ID" value="NSJP_1599"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1599"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015059">
        <property type="entry name" value="Ca_cell_adhesion_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08964">
        <property type="entry name" value="Crystall_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="SSF49695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012822705" description="Crystall_3 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Crystall_3" evidence="2">
        <location>
            <begin position="63"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="130" mass="14156" checksum="F13463D3836ADB8D" modified="2017-06-07" version="1">MSYMKVFAAGVGITMGLLGGLPAQAADVEMQVVDKNCYIEIFEDDNYDADDPHIKIQGPKEFATLKSLQGKDWANDIESVIVGSNATVYAYEDKDFKGTEIVFAPGQKVPNLGKLDMANDIESMKIVCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4J2</accession>
    <name>A0A1W1I4J2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sortilin-Vps10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1723"/>
    <dbReference type="EnsemblBacteria" id="SLM47895">
        <property type="protein sequence ID" value="SLM47895"/>
        <property type="gene ID" value="NSJP_1723"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1723"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sortilin-Vps10" evidence="1">
        <location>
            <begin position="42"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="340" mass="36920" checksum="262102EC9E73EB20" modified="2017-06-07" version="1">MRLVFLLLSLVAIAGCDRSDPIVLIQLHPTNPDIMYVATNDYIYKTRDRGQTWTNLSQGMSHSRVISMAVDPTYPATVYAGTKGDAVFKSHDGGQRWVSMRSGLDDATISSVVNQFVFDPAESNHIYLATTMGVFETNNGGDNWIKKMEGMKEVLMVVTLGMDSSRPEVLYAGTSGGVYKTSNKAARWDKVNNGLVAPDMIKTSRALNVTAVVVDPFASDTVYAATLTGLYRTTDGAKSWTRIGQSLADQMIIGMIVDRTKQGVIYISGRDGIHRSEDGGSTWKTMNRGLITTNVRCIVQSSTDPKVFYAGTNGSGLYRSGDGGETWDAMPAIVPVKATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4L0</accession>
    <name>A0A1W1I4L0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fabG</name>
        <name evidence="4" type="ORF">NSJP_1770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1770"/>
    <dbReference type="EnsemblBacteria" id="SLM47942">
        <property type="protein sequence ID" value="SLM47942"/>
        <property type="gene ID" value="NSJP_1770"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1770"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="63"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="155"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="248" mass="26112" checksum="C773A56DF6E33508" modified="2017-06-07" version="1">MASLEGRVAIVTGAAQGIGRAIAESLAKAGADIVVADLDPARSKETVSAVEQAGRKALNVKVNVADANDAKAMADHVLKEWGKIDILVNNAGITRDGLLLRMKEEDWNLVLQVNLTGTFNCTKAVLQPMTKQRYGRIVNIASIVGAMGNVGQANYAASKAAVIGFSKTVAREYASRNVTVNAVAPGFIDTAMTQGLSTEVKETLQKQIPLGRLGTPQDIAAAVRFLVSEEAAYITGHVLHVNGGMLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4X2</accession>
    <name>A0A1W1I4X2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48042">
        <property type="protein sequence ID" value="SLM48042"/>
        <property type="gene ID" value="NSJP_1870"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1870"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="96" mass="10890" checksum="93C6F5347F33803B" modified="2017-06-07" version="1">MSRFVGHCVVMGVKARPSQDGKRIFRNAVLYFEEDTSTLEASVSEDHEHLYKLMEANKMKPCQITVNLREFKGQRFLDVTGYQPGIITPGTKGPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Y3</accession>
    <name>A0A1W1I4Y3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47883">
        <property type="protein sequence ID" value="SLM47883"/>
        <property type="gene ID" value="NSJP_1711"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1711"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012867951" evidence="1">
        <location>
            <begin position="31"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="177" mass="19491" checksum="DC312A910EB0EDC8" modified="2017-06-07" version="1">MAKPSYCSVLLRGVLSTASTLLLSSLVAFAVPLQHDPNGFEGIPWGAALSESETFGKTEEAGRLKTYEGKNAPPHLGPSQVESMKFTTIDDQFARVTVRYQGKATHDEILAYLQSLYGPLDDALEQFSVGPVKFYAWQGFETEVTLRYENRADRGIIFFESQTLRGKIADGNSATVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I513</accession>
    <name>A0A1W1I513_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48108">
        <property type="protein sequence ID" value="SLM48108"/>
        <property type="gene ID" value="NSJP_1936"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1936"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="10"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="162" mass="17805" checksum="7687CA647996620F" modified="2017-06-07" version="1">MSDLQLTPISILFVDPDIEDRAYWVRRLELASPEYVITTVEEGRTAIEMCRSRRFDCVVLELKLPDISGFEVLTHLCPVASQPDVAVVILTKLLFTTLSAAARTNGAQSYLIKPQTSGDQLDTAIQKAVARVGPTSKRLPTQAMLNDRESLRGGAESETIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I561</accession>
    <name>A0A1W1I561_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Hydrolase, alpha/beta fold family</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1986"/>
    <dbReference type="EnsemblBacteria" id="SLM48158">
        <property type="protein sequence ID" value="SLM48158"/>
        <property type="gene ID" value="NSJP_1986"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1986"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="68"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="330" mass="36907" checksum="6758B579F3DC54C8" modified="2017-06-07" version="1">MTPLPDFVPSPLLRNPHLMTLLPRYWPRGRPLHGIPVESRLFTVADDTKLLGFCHWQEDRRAHRTVALVHGLEGCSESHYMHGIAAKAYRAGMNVIRLNQRNCGGTEHLTPTLYNSGLGGDYRRVVDELVRTDGLTGMWLVGYSMGGNLVLKAAGEAASSQPALAGVVAVCPNIDPTQCVAALEHPRNWIYHNHFLTSMKARMHRKAVLFPGRWDLAELNAVRTLREFDDRYTARDGGYRNGADYYDRAGSRHVLKSIAVPAVIITAQDDPFIPFAMFDASAIRDNPNIRLIAPRHGGHCGFVQPNRPNEDRFWAENRIIEVMTGQAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5A3</accession>
    <name>A0A1W1I5A3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Peptidyl-prolyl cis-trans isomerase D</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2025"/>
    <dbReference type="EnsemblBacteria" id="SLM48197">
        <property type="protein sequence ID" value="SLM48197"/>
        <property type="gene ID" value="NSJP_2025"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2025"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="232" mass="26253" checksum="EC2E92E7B0909483" modified="2017-06-07" version="1">MIKLMREASHSYPWLLKSIMGILAIAFVITMGWWGFGEQRGSVVAAVGDLTVSHDEFRRAYENSYRFYKDKLPGEFKDETIKQVVVEQLIDNRVWLVAAKNMGLTVSNEDLRDAIMQIPEFQKNGAFDPDLYQRLLAANHLTPSLFESIEAKELLGNRARMMISEAVTLTPAELAEAQALVIRQPESDPSKAAAAKDRAMQDVLFQKQQRALMAYTQSLKAIIPITIHRELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5B1</accession>
    <name>A0A1W1I5B1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="8">KARI</shortName>
            <ecNumber evidence="8">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="8">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">ilvC</name>
        <name evidence="12" type="ORF">NSJP_2014</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2014"/>
    <dbReference type="EnsemblBacteria" id="SLM48186">
        <property type="protein sequence ID" value="SLM48186"/>
        <property type="gene ID" value="NSJP_2014"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2014"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="10">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="11">
        <location>
            <begin position="181"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="24"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM48186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="337" mass="36762" checksum="BCA005304F0431B1" modified="2017-06-07" version="1">MKIYYDKDADLQHIRNKTVAVVGYGSQGHAHALNMKESGVSVVIGLREGASWKKAEHSGLKVMPVADAVKASDIVMILAPDEAQAAIYRQEIAPNLKPGAYLAFGHGFNIHFGQIVPPPSINVFMVAPKGPGHLVRSEYTKGSGVPCLLAVHQDPSGTTRQVGLAYASAIGGGRAGVIETNFREETETDLFGEQAVLCGGLTSLIQAGYETLVEAGYSPEMAYFECLHEVKLIVDLIYQGGIANMRYSISTTAKYGDVTRGPRVVTEQTKQEMKQILREIQEGRFAKEWVLENQANRPVYNALLAKGEAHPIEAVGARLRAMMPWLKKDQLVDKNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5R2</accession>
    <name>A0A1W1I5R2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="NSJP_2174"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
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        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="240"/>
            <end position="263"/>
        </location>
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            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
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            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
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        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="430" mass="45901" checksum="214326C75DDA56A6" modified="2017-06-07" version="1">MAFPACRPLTFIMTGFGWLLLASLLGMASLIGLVRGTPLPPGLRLVHVHGALVGGVAQMIMGAMLTFVSTLLMTGRDRRDSHPVLFAAMNGGALALVLGFGFRNYQVVAAAGCVVLAAFFWVGRDTWQQARRSVNRPPLNVWYYALALAALAGGLALGIGMAAQVIQPAWTGSARLVHLHLNLMGFVTVTIVGTMHNLLPTILQQPLHNPRLSRLVFFLLPAGIAVLISGFALSSLSIEFIGGTALALAVCLYAFNLFATWRASSRPGDAASDHLLTATFFLVLAVFMGLLVAANYLGEHPFLPFGTLHLVAYTHTALTGFVLQTIFGALSHLVPVTLAAHRVASNKKRGPYLDMLIRIMNRWRVAQVVGLSMGTAGLGLVASLTWTAPLGSVVVQTAVWVTFGLFLTSLTLFSVKLAWVFSTRAGKDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5T1</accession>
    <name>A0A1W1I5T1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Heavy metal efflux system, outer membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2057"/>
    <dbReference type="EnsemblBacteria" id="SLM48229">
        <property type="protein sequence ID" value="SLM48229"/>
        <property type="gene ID" value="NSJP_2057"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2057"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="428" mass="47469" checksum="E696B3A9F7C2E2FB" modified="2017-06-07" version="1">MTHQRLSSLIFLTAALQIGAVTTRSQAVEPAGTSTYQLGTIIEMALARNPVVSSAEGDIEHQRGQQTAAGAYPNPTVMGNAGYGEIRDTGRADIRDSLNRESIFEYNFILGQPVEWPAMRSARKRVADAGLATANAGMSETRLNLAAQVKVAFYDLLLAQQDAALAQQNLEIVEGVGRIVKARVKSGEAPQFELIKAEVEILKAKQLLVRAENVVRVNRVIVDTFTGGGLGTSYVVQGDFLNMPRELRIDALMAKMVQEHPTIRRLLQSVEQSDWRIEFERQSRVPNVTVNGSYWREIGREAVQGGLSIPVPVWYRRQGEIAASLGTKRREEAELLRARNELARAVHQHYQDARTTAELIDVFDKGLLKQAQEALRLAQFSFQQGASSLLEVFDAQRVQRQIQMDYAQVRYELSVSLARLERAVGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I621</accession>
    <name>A0A1W1I621_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48462">
        <property type="protein sequence ID" value="SLM48462"/>
        <property type="gene ID" value="NSJP_2290"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2290"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="81" mass="9484" checksum="4C3BC3FAC713AD99" modified="2017-06-07" version="1">MLRRTLKRSSKGKYMHFLHTPSKEEVELRHTNDYNLPTSARMRRRKDGNKRISRSHWSCYCGDPTGQDSCGDPSDRSTEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I661</accession>
    <name>A0A1W1I661_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type transport system, ATPase component</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_2312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2312"/>
    <dbReference type="EnsemblBacteria" id="SLM48484">
        <property type="protein sequence ID" value="SLM48484"/>
        <property type="gene ID" value="NSJP_2312"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2312"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="332" mass="36301" checksum="876DF9F25B87762A" modified="2017-06-07" version="1">MIDVQQVTKRYGQHTAIDRVTFSVAKGEVLAFLGPNGAGKTTTMRILTCFLPATEGSARIAGYDCQDQPLEVKRRIGYLPETPPVYQELTVDEYLRFVGQLRGLTSNTLTAAINREVERLGLGPVRHRLIGNLSRGYRQRVGLAQALVHDPPVLILDEPTVGLDPKQIIEIRELIRSLAGSHSVILSTHILPEATAVCQRVVIISAGRIVAEDTPDQLSARLRNSEKISVVLKRPPGDVEARFKEIPGVQHVLAGGEGGGFLLESELGHDIREDVGRLAVNSGWGLVELKPVSMTLEDVFLRLTRHEESMGEPGQGSGQTELEPMERAETSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I679</accession>
    <name>A0A1W1I679_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_2207</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48379">
        <property type="protein sequence ID" value="SLM48379"/>
        <property type="gene ID" value="NSJP_2207"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2207"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="530" mass="56385" checksum="3DFACE4EFED8765A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6C5</accession>
    <name>A0A1W1I6C5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_2385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2385"/>
    <dbReference type="EnsemblBacteria" id="SLM48557">
        <property type="protein sequence ID" value="SLM48557"/>
        <property type="gene ID" value="NSJP_2385"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2385"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017778">
        <property type="entry name" value="ABC_transptr_urea_perm_UrtC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482:SF4">
        <property type="entry name" value="PTHR30482:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03408">
        <property type="entry name" value="urea_trans_UrtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="379" mass="41208" checksum="5AC775D114CF0082" modified="2017-06-07" version="1">MADARDIQPSAPREASLAFWVSGFVLLVVMPLLNVLPAEDSWLHLSDFSLNRFGKFLAFAILALGLDLIWGYTGILSLGQGVFFGLGAYCMGMHLMLTIGKESVYGSDLPDFMVWNQVKELPLFWQPFHSFPLAVLGAVLVPTFFALVFGFLAFRSRIKGVYFAIITQALALVAWLVFNRNETNLGGTNGLTDFKQLLGFRLSEPGTQRALYVITVLCLGGAYLLCQWIIRSRAGRVLIAVRDSEQRVAFSGYAPANYKLFVFVVAAALAGLAGLLYVPQVGIITPAQIGVLPSLEMVIWVAVGGRGTLAGAVLGAVSVNLGRSVLTNYFPELWPFMLGGLFVTVVLLFPDGLVGILHKLKDRVASRKTARLAEGEAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6F5</accession>
    <name>A0A1W1I6F5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative branched-chain amino acid transport protein (ABC superfamily, peri_bind)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2383"/>
    <dbReference type="EnsemblBacteria" id="SLM48555">
        <property type="protein sequence ID" value="SLM48555"/>
        <property type="gene ID" value="NSJP_2383"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2383"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06355">
        <property type="entry name" value="PBP1_FmdD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017777">
        <property type="entry name" value="ABC_urea-bd_UrtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03407">
        <property type="entry name" value="urea_ABC_UrtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="453" mass="49916" checksum="BACCD6EEB9A034B7" modified="2017-06-07" version="1">MENKKQQTEITSTEPSMDGGPSRRDFLVRGARLTAGVGVAALLGNLGQWALSYAADKEPIKIGVLHSLSGTMAISEVSLRDVVLMAIEEINAKGGVLGRQVKPVVVDPASNWDLFAEKAKQLLLQDKVSAVFGCWTSVSRKSVLPVFEKNNGLLFYPVQYEGEECSRNVFYTGAAVNQQAVPAVEYLMSKDGGSYKKFYLLGTDYVYPRTTNKILRAMLLAKHVPEAGIMEEYTPFHHQDYQTIVGKIKKFAAGGGAAVISTINGDSNVPFYKEFANQGLRAEDAPIMAFSVAEDELRGMDTTALVGHLAAWNYYQSVDTPQNKQFVSNFKAYCKKNSLPDGDKRVTDDPIEAAYFGVYMWKQAVEKAGAVDVDQVRKAVYGQKFLAPGGEVMMDTGNHHTHKPVLIGEILKDGQFKVVSRSKGLVKPEPWSEYTNPDKGCDWISHQGTYQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6G6</accession>
    <name>A0A1W1I6G6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48469">
        <property type="protein sequence ID" value="SLM48469"/>
        <property type="gene ID" value="NSJP_2297"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2297"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="55" mass="6289" checksum="75BF5CE5ED088C9F" modified="2017-06-07" version="1">MTLLSRLDERVFIGPVKSRAHPTMRIEQHKGSATAFGRTCRGRRRRRSKPGSEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6J4</accession>
    <name>A0A1W1I6J4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ANTAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2379</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2379"/>
    <dbReference type="EnsemblBacteria" id="SLM48551">
        <property type="protein sequence ID" value="SLM48551"/>
        <property type="gene ID" value="NSJP_2379"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2379"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="346"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="421" mass="47352" checksum="61587C8F54184010" modified="2017-06-07" version="1">MASTRPLSIAQLEQAFREKSREVDVLHRITDSISNTLDLEAVLKHIVEVVVEVTKADACLLYLLSDKGDELILRASKNPHPKLIGRITIGMGEGITGWVAQERTRVVIPSNASDDSRFKFFHNLPEDRHQAFVSVPIMAKKEVVGVINVQHRRPKRYRPDELALLSTIANQVGGAIENARLYEQMRRKALQVETLSQVSETVASNRLIEDVLQLLVTMTAQMMNSKICSIMLLDGATGDLRIEATQSLSELYRRKPNLKIGQSISGRAVQERRPIIVADVMKEPNYMYPDMARKEGLCSLLCVPMLVREKAVGVINSYTSAPYSFTSEEVKLLQAIANQAAIAIEHTTLLEKSFEMQEALAVRKLLDRAKGYLMRSKKLSEEEAFRLIQRQSMDLRKSMREIAEAVLLAGELDERADKQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6M7</accession>
    <name>A0A1W1I6M7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48644">
        <property type="protein sequence ID" value="SLM48644"/>
        <property type="gene ID" value="NSJP_2472"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2472"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="206"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="496" mass="56471" checksum="28BF7E6FC00097F6" modified="2017-06-07" version="1">MKPAVALHEPRSLEGETLSLLSWHIPDLVAYQHSEDEWWFAPLDDNLPIVRLNRTGLEMLTSMNGHTTVRALLEKYGSKVCGPDGEPGRWHLERWSLPTYSLCFYGAEPPGGHRHKAKWDVLLQQIREGWSGQEGFEGEEHLEDFHAHELTEGGEDDGHFDLIETTVSHLFREPNETLNGLSYGRLLMQKLRRLGWFSPKPKVLVEIGGGLGYVARELGKELLPFEKQGVKYLSVDITKPFLKRQLVRAAEGGWSCTGARANGEFLPFKDNSVDLVIDNENMADMTPVKLSRRELTSGSGDTPQHQEALDWIRRMRLPIGNDPPDDVIFNLGPLRFVAELWRVLKPGGRAFLTEFGIEDGWPAPVKLPGHTEYEVQYAHLRQAVRWLGFQEQFLTLPQFLTIKPSVKVLCTGAAYTIQRFCRGINRPFIVRAYTEREIQEALGDMLPRLQGLHYHDVADPAWFGLIDFKVLLLEKPGGAPRTNFTETNGYRWYAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I705</accession>
    <name>A0A1W1I705_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2544"/>
    <dbReference type="EnsemblBacteria" id="SLM48711">
        <property type="protein sequence ID" value="SLM48711"/>
        <property type="gene ID" value="NSJP_2544"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2544"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="816" mass="89790" checksum="CA35832A3E5AE79D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I715</accession>
    <name>A0A1W1I715_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="7">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">aspS</name>
        <name evidence="9" type="ORF">NSJP_2487</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2487"/>
    <dbReference type="EnsemblBacteria" id="SLM48659">
        <property type="protein sequence ID" value="SLM48659"/>
        <property type="gene ID" value="NSJP_2487"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2487"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="149"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="200"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="222"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="534"/>
            <end position="537"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="7">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="587" mass="65173" checksum="3FA8D9F40939FD7A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I730</accession>
    <name>A0A1W1I730_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4136 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2507"/>
    <dbReference type="EnsemblBacteria" id="SLM48679">
        <property type="protein sequence ID" value="SLM48679"/>
        <property type="gene ID" value="NSJP_2507"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2507"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025411">
        <property type="entry name" value="DUF4136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13590">
        <property type="entry name" value="DUF4136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4136" evidence="1">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="65" mass="7128" checksum="2387ABC789CDCBE4" modified="2017-06-07" version="1">MASGSSVTTPTTVVIGTIHVDIYDAKNKQMIWRGTGSDTVSQNPEENTEKIREVASAMFEKFPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I738</accession>
    <name>A0A1W1I738_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48689">
        <property type="protein sequence ID" value="SLM48689"/>
        <property type="gene ID" value="NSJP_2517"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2517"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="3">
        <location>
            <begin position="70"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="401" mass="42689" checksum="F60C82197940D525" modified="2017-06-07" version="1">MARSRIPGFSPSGAVFLTIVGLAALGASGCERKDAVSALAPDVLVTEVVRRDVPIYAEGVGTTAGTIDAQIRAKVQGYLLTRNYVEGSYVKAGDLLFKIDARPYQASFDQLRGELARAEAAYKKTQMDVARDTPLAKQGAVSQKELDDSIQANEANKANVFSARANLEKGKLNLDWTSIASPVDGVAGVASAQIGDLIMENTVLTTVSQVDPIKVLFPISEKMYLRFAERIQKAVANPTGDQRSSAPLELILADGTVYAHKGKAALPDRQVDVKTGTITIVSYFPNPGNVLRPGQYAKVRAVVETVRDALLVPQRAVQELQGIYQVAVVDADNKIAVRSVKPGARIGSQWVITSGLNQGERVVVEGLQKVRSGLVVSPKPVPPEPASTDPDRQPAPPAAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I779</accession>
    <name>A0A1W1I779_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative alpha-glucosidase</fullName>
            <ecNumber evidence="2">3.2.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aglA</name>
        <name evidence="2" type="ORF">NSJP_2562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.20" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2562"/>
    <dbReference type="EnsemblBacteria" id="SLM48729">
        <property type="protein sequence ID" value="SLM48729"/>
        <property type="gene ID" value="NSJP_2562"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2562"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032450">
        <property type="term" value="F:maltose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="18"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="563" mass="64776" checksum="418B9F74F0118F36" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I793</accession>
    <name>A0A1W1I793_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">STN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_2703</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2703"/>
    <dbReference type="EnsemblBacteria" id="SLM48870">
        <property type="protein sequence ID" value="SLM48870"/>
        <property type="gene ID" value="NSJP_2703"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2703"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07660">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0798">TonB box</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="STN" evidence="10">
        <location>
            <begin position="124"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="42"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="903" mass="97919" checksum="BA0B801D8106D1D1" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7B2</accession>
    <name>A0A1W1I7B2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3">4.6.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">moaC</name>
        <name evidence="7" type="ORF">NSJP_2644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2644"/>
    <dbReference type="EnsemblBacteria" id="SLM48811">
        <property type="protein sequence ID" value="SLM48811"/>
        <property type="gene ID" value="NSJP_2644"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2644"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="6">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="159" mass="16856" checksum="72B7D2497D8077FE" modified="2017-06-07" version="1">MVDVSAKAQTERLATAQAKVFLRPETLEKIQQGKIAKGDVLAVAQIAGVMGAKKTPDLIPMCHPIFLSSVDISFAEDARPNRDGRCSITVTATAKTTGQTGVEMEAMTAVSVAALTIYDMCKAIDRDMSFSDMCLLTKSGGKSGSYKRDGTDSVGTEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7E4</accession>
    <name>A0A1W1I7E4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48968">
        <property type="protein sequence ID" value="SLM48968"/>
        <property type="gene ID" value="NSJP_2801"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2801"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="34" mass="3442" checksum="FFA07717FC99FC87" modified="2017-06-07" version="1">MASSNRLFYDPAMPTNAGTGSVVLDRAVPGSDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7I0</accession>
    <name>A0A1W1I7I0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2596"/>
    <dbReference type="EnsemblBacteria" id="SLM48763">
        <property type="protein sequence ID" value="SLM48763"/>
        <property type="gene ID" value="NSJP_2596"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2596"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="5"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="388" mass="42131" checksum="4F590F7453188EDB" modified="2017-06-07" version="1">MDAYDVCIVGAGVVGCALARELTMRARDRSLRILVLEQHRGAGEETSSRNSGVLHGGIHEDPATLKGRLAQEGSRLAVSYAVERGIPLLRSGMVIAVTWKDIRSGLWRDITMLRRLWVNARRSRLPVSFVTARGLRRWEPHLQACGAIVIPSICVIDPTAWVSALKADAEAAGVTFAFEQRVVGIDPEDDGYMVTTDRKRIRTDGLINAAGLHADEVASFLSGKSSYTIRPLRGEYYEIVAPEKKGLIGRLIYPALPPGAAGKGIHFGPRPNGRLYIGPNEVAVRDKTDYTSNQTPPGQFITAVQRFLPSLEEGDLRWAYSGIRPSIMTDGGRKQDFIVAVAREAPPFVNLIGIESPGLSAAMGLARHVVNLPCVTGRWRLPAAAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7I4</accession>
    <name>A0A1W1I7I4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent RNA helicase DeaD</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">deaD</name>
        <name evidence="11" type="ORF">NSJP_2778</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2778"/>
    <dbReference type="EnsemblBacteria" id="SLM48945">
        <property type="protein sequence ID" value="SLM48945"/>
        <property type="gene ID" value="NSJP_2778"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2778"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="50"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="251"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="451"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="465"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="578" mass="62317" checksum="746332697A8A21A4" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7X4</accession>
    <name>A0A1W1I7X4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_2918</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2918"/>
    <dbReference type="EnsemblBacteria" id="SLM49085">
        <property type="protein sequence ID" value="SLM49085"/>
        <property type="gene ID" value="NSJP_2918"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2918"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="271"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="545"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="777" mass="86201" checksum="0DAD4C7D1801CF73" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I879</accession>
    <name>A0A1W1I879_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49214">
        <property type="protein sequence ID" value="SLM49214"/>
        <property type="gene ID" value="NSJP_3047"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3047"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="80" mass="8803" checksum="B952CCA22F4702A0" modified="2017-06-07" version="1">MGRWKNKEKREDEVIQTLGCSNFAHELGVAAGTVGMREQALARIDLVRLLVEPGRYPALRSGRALGFNANQPTHATDGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8A7</accession>
    <name>A0A1W1I8A7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myeloperoxidase, thyroid peroxidase, cyclooxygenase catalytic domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3111"/>
    <dbReference type="EnsemblBacteria" id="SLM49278">
        <property type="protein sequence ID" value="SLM49278"/>
        <property type="gene ID" value="NSJP_3111"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3111"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012235635" evidence="1">
        <location>
            <begin position="34"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="540" mass="59588" checksum="537F343C7A2A38B3" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8B7</accession>
    <name>A0A1W1I8B7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CxxC_CXXC_SSSS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49288">
        <property type="protein sequence ID" value="SLM49288"/>
        <property type="gene ID" value="NSJP_3121"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3121"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="74" mass="7779" checksum="A450B64ABB4EBF6C" modified="2017-06-07" version="1">MPIFEYVCRECNHRFELLVQGAMQPACPQCRSTDPEKQFSAFGVGATESWATSSGGGACGSCGDPRGPGACSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8F8</accession>
    <name>A0A1W1I8F8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5069 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49280">
        <property type="protein sequence ID" value="SLM49280"/>
        <property type="gene ID" value="NSJP_3113"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3113"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031849">
        <property type="entry name" value="DUF5069"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16798">
        <property type="entry name" value="DUF5069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5069" evidence="1">
        <location>
            <begin position="2"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="140" mass="15899" checksum="B73DF105281DD301" modified="2017-06-07" version="1">MTLGGYVHLARMIDKCRAVLAGTEGEYIYPCPLDKRLMEFAGVTAEQFTEAVTASRTDEEMIAWFQRTATPRPQSEVDQWNRALLLRGPSSTDSQKRFDAYRDAVDPSRTDLTSWADLQDLEEGRDVPCRQAANSDRETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8K5</accession>
    <name>A0A1W1I8K5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lipoprotein-releasing system, transmembrane protein LolC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">lolC</name>
        <name evidence="11" type="ORF">NSJP_3211</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3211"/>
    <dbReference type="EnsemblBacteria" id="SLM49378">
        <property type="protein sequence ID" value="SLM49378"/>
        <property type="gene ID" value="NSJP_3211"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3211"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011925">
        <property type="entry name" value="LolCE_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02212">
        <property type="entry name" value="lolCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="10">
        <location>
            <begin position="28"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="9">
        <location>
            <begin position="321"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM49378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="426" mass="46111" checksum="BEA8D58A80AD78E1" modified="2017-06-07" version="1">MAALPYEIFVGLRYLRAKRRNRTISLNTFVSVTGVTLGVAALIGTVGIMTGFKEDIQAKIVGTTAHVIVQDRMKDAMSDYGPVVQRAETVPDVVAATPFILKQVMLTTQAGAHGVVLRGIDPTKEGKVTELEKNLAAGNLSDLGHPVTVNLPPADNPNGPPQPSEKPGIILGKELALRLGAFPGDIVSIVSPVGPISAMGMVPKIRPFAVIGIFHSGMYEYDSSLAYIDLAEAQKFFGMGDTVTGIELKVTDVFRANEVARSVEQALGFSYGARDWMQMNRNLLSALKLEKTMMFLLLVLITIVASFNIVSTLTMIVNEKQKEIAILKAMGATRKSIRRIFMLNGLIIGLSGTAIGIPLGYTFLWLIQTFWTFDPTVYYISKIPVHVLGEDVLLVAGSAILISFAATVYPSLQAAKLEPVDALRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8R1</accession>
    <name>A0A1W1I8R1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49375">
        <property type="protein sequence ID" value="SLM49375"/>
        <property type="gene ID" value="NSJP_3208"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3208"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="202" mass="22629" checksum="AC536078A510A155" modified="2017-06-07" version="1">MLTIRLRFTSFAFLLLFLLFAGCGGLQEVWEGPGAKVFRPQAIAVLPPMASQYDSAREDIQDVLSGSLTKVANIERVVSPESVTDIFQGSKEAFDSLVFYFSRLEMTGQSDKESAIKLGKALSVDSFLVVRVNSWEYVRKEGDNVGRVGLSLRLVDATTGTTVWKARHERSSSYMFYRPNLKDVAKDLADEMIKYMPPTPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8U4</accession>
    <name>A0A1W1I8U4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ysgA</name>
        <name evidence="3" type="ORF">NSJP_3301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3301"/>
    <dbReference type="EnsemblBacteria" id="SLM49468">
        <property type="protein sequence ID" value="SLM49468"/>
        <property type="gene ID" value="NSJP_3301"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3301"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012867958" evidence="1">
        <location>
            <begin position="38"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="DLH" evidence="2">
        <location>
            <begin position="62"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="287" mass="30892" checksum="B761F7C76B377E0A" modified="2017-06-07" version="1">MAGHNPMPNSSPAMTRRGFVTATLAAGFALAVRPISAATIATDEAELTAGEIRISTGDGPMPAYRAKPQSGAGFPVVLVVQEIFGVHEHIKDVCRRFAKLGYLAIAPELFTRQGDVSKMTDIDEIRSKVVSQVPDAQVLSDLDAAVAWAKESGEGNIERLGITGFCWGGRIVWLYAAHNPQLKAGVAWYGRLAGNPTPLQPKHPLDVASSLKAPVLGLYGAEDKGIPLDTVEQMKATLQSAGGTSQFVIYPNAPHAFHADYRPSYRKEAAEDGWKRLQDWFKKNGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8W3</accession>
    <name>A0A1W1I8W3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49440">
        <property type="protein sequence ID" value="SLM49440"/>
        <property type="gene ID" value="NSJP_3273"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3273"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="120" mass="13609" checksum="F5EE1A793B0DD84F" modified="2017-06-07" version="1">MDIVSPKGWLAVLVGCRRLFRHAMTAKIEAYKAELFSQSGLVLFEPGERTEVDARNQEDGPAVGLAEFVHGQPEPTASRDVLSGHRCRALNRRMRMVCLDLYCVNRDHVAFSEFRSLKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Y9</accession>
    <name>A0A1W1I8Y9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ap4A phosphorylase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3293"/>
    <dbReference type="EnsemblBacteria" id="SLM49460">
        <property type="protein sequence ID" value="SLM49460"/>
        <property type="gene ID" value="NSJP_3293"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3293"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="PTHR38420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000846">
        <property type="entry name" value="ATP_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A_phos_N" evidence="3">
        <location>
            <begin position="5"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="ATP_transf" evidence="2">
        <location>
            <begin position="181"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="297" mass="32832" checksum="5783A8D1E80B24F4" modified="2017-06-07" version="1">MTDQAQHLTPGTLPASLRERMEHARRCGAIQFMQTCLDVIEQEGIPFQVRIMESLAKKATAASGGANVNPFLPCDPDLFVAPISPTHLALLNKFNVVEGHLLIVTRSFEDQCCQLTQKDCEALLITLTEIDGLIFYNAGREAGASQSHKHFQLLPLDAIGPIPIEPLFRFAHPDEMVGTVPKLQFRHAYAGMDADWTNPEKLSGASFHACYRQLLHTAGLSVEAATGSHALTAPYNLLVTRKWALLVPRSRERFEDISINALGFAGTFLVKDQRQLETLRRMGPLTALRHVSFPNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I917</accession>
    <name>A0A1W1I917_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3323"/>
    <dbReference type="EnsemblBacteria" id="SLM49490">
        <property type="protein sequence ID" value="SLM49490"/>
        <property type="gene ID" value="NSJP_3323"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3323"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="42"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="111" mass="12273" checksum="DC3300A5B7A9A2E5" modified="2017-06-07" version="1">MALHDRKPSRTIRLVTVTMAGGILATLAACDPFRPTADRYFDDGEITVAIESRLAYEKVVDPARVEVETKNGIVHLRGTVETLDQRMQAGKVASQVTGVTSVDNELEIYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I918</accession>
    <name>A0A1W1I918_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49485">
        <property type="protein sequence ID" value="SLM49485"/>
        <property type="gene ID" value="NSJP_3318"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3318"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="208" mass="23685" checksum="C47B3480566482FC" modified="2017-06-07" version="1">MFHDSFLRHSGNGRPCPHCSSTKTNEISQYLLGCSHLALQRCGQLLLKAAARFDGGEEEAALEQAIHSREELDRSRYLEDQWRVGLSGTSISVTDIETHLKEHLEKQECNRGVTQPPRGAAAIYTSAPDRRTGSHDTDENDRSQRREAIRQYMLDVIGIYTYRWDRLQSFDLLNLSDPELAHAYMRLSDRLTLPAPPDMTVPRRASTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I927</accession>
    <name>A0A1W1I927_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49495">
        <property type="protein sequence ID" value="SLM49495"/>
        <property type="gene ID" value="NSJP_3328"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3328"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="63" mass="6931" checksum="2EEAAEB7E748723E" modified="2017-06-07" version="1">MPHRSWIVQKTARRMDRAGLAVALAFLVALGFWAGFRGERAEDTASPEQQTLETPTHPPASTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I929</accession>
    <name>A0A1W1I929_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49506">
        <property type="protein sequence ID" value="SLM49506"/>
        <property type="gene ID" value="NSJP_3339"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3339"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="52" mass="5931" checksum="4517E4031DDA1F8A" modified="2017-06-07" version="1">MKIGYARRVSSSHDILCQIDHVLSLLSKLNARIQLRVVRGEAMVIVQIMDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I953</accession>
    <name>A0A1W1I953_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Formate hydrogenlyase, large subunit</fullName>
            <ecNumber evidence="3">1.12.7.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.12.7.2" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3391"/>
    <dbReference type="EnsemblBacteria" id="SLM49558">
        <property type="protein sequence ID" value="SLM49558"/>
        <property type="gene ID" value="NSJP_3391"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3391"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="1">
        <location>
            <begin position="34"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="2">
        <location>
            <begin position="294"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="2">
        <location>
            <begin position="456"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="528" mass="59913" checksum="FB85017EBE6DF431" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9C3</accession>
    <name>A0A1W1I9C3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase C</fullName>
            <ecNumber evidence="2">3.1.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3236</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial phospholipase C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.3" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3236"/>
    <dbReference type="EnsemblBacteria" id="SLM49403">
        <property type="protein sequence ID" value="SLM49403"/>
        <property type="gene ID" value="NSJP_3236"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3236"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034480">
        <property type="term" value="F:phosphatidylcholine phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="582" mass="63348" checksum="46EBA126EACC697D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9I6</accession>
    <name>A0A1W1I9I6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3478"/>
    <dbReference type="EnsemblBacteria" id="SLM49645">
        <property type="protein sequence ID" value="SLM49645"/>
        <property type="gene ID" value="NSJP_3478"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3478"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="417" mass="42470" checksum="6AEF4EBB9CA0ED1E" modified="2017-06-07" version="1">MVFYLLGITVPLTDRPHKIHITPPARTARGLWAPFLSVVCLSGLIGCNDVSKAPDPAPGPGALAIVSLSLPDGVVNQPYATTVGGSGGITPYQWSVSPLLPRSLTLDPSTGAISGTPEIVGTTSHTFALHDASNPAQSTQVTLSLTINAAPAVLAITTTSLPSGTVGQQYSRTIQATGGTAPLSWSIVAGALPQNVAFNSQTGLVSGTPTAVGTSNFTVRVVDTTGQADTQSLSILINPSAPPNITTASALPGGTVGLPYSQTLAASGGTGTLVWSRTVGSLPANLALNPAGIISGTPTNTGTSTFTVRVTDALSQSDSQQFSLTVSAALTITTTSLDNGRVRRSYDETLRSSGGTAPFTWTVSPPLPAGLVLNAATGNISGTPSSTSNVVYDFTVRDSTTPTNQTFTKSIRLRVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9K6</accession>
    <name>A0A1W1I9K6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Histidine kinase</fullName>
            <ecNumber evidence="5">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_3505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3505"/>
    <dbReference type="EnsemblBacteria" id="SLM49672">
        <property type="protein sequence ID" value="SLM49672"/>
        <property type="gene ID" value="NSJP_3505"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3505"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="133"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="383" mass="41782" checksum="93501FE7E8B4E7E1" modified="2017-06-07" version="1">MPVRILVADDEPDILLSLAERFRWMGHEVITAGDGQAAVTAVESALVDVVFLDITMPKLSGMDALKRIKKRWPTLPVVMLTAYGSIQRAVEAMKEGAVDFVTKPFEPGQIDSVLALALERREQAGDMTQLLGEISHDVKNLLMPMVTGTDLLAEEIDDLFKSLPEHTSIRLDGHHQTCEEVLQLLRNTSRRIQDRMKEIADYVAVASAPQRLEPCHIGKIADGVAKTLRVLVQQKQITLRLEDLESLPTIIGDANRLYSLLYNLVHNAVPEVLPSGSITIRGRHDSGTQSIVLMVEDTGKGMPEEVRQTLFTGRVISRKAGGTGLGTKIVKDVVDAHGGHISVGSREGLGTTFVITLPIHPPAFPPATQSVPPNTPELGGTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9L4</accession>
    <name>A0A1W1I9L4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fabF</name>
        <name evidence="14" type="ORF">NSJP_3515</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3515"/>
    <dbReference type="EnsemblBacteria" id="SLM49682">
        <property type="protein sequence ID" value="SLM49682"/>
        <property type="gene ID" value="NSJP_3515"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3515"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="5"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM49682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="418" mass="44077" checksum="0901FDF4666399D4" modified="2017-06-07" version="1">MKSRVVVTGLGIVSPIGIGVSEFWKSALDGRSGISAISGFDPFPMDGYRSKVAGQVREFDPERYLEPQYADRVDRYAQFALVAAKEALTDSGIAMSKENPHRVGVIVGAGMGGMVMGEREITQLYQHQRPHRVHPNFIPVITLNSASGIVAMATGAKGPNVTISTACSSSAHALGQALHCIREGRADVAIVVGADASITPLVFAGFCSLRALSTKYNDQPEKASRPFDSGRDGFVMGEGAGALILESLSHARRRKARVYAEVAGYAATSEAYHMVIPREDGEEVAATMRLALADAGTTVAQVDYINAHATSTSIGDAVESKALRQLFKSRAENITISATKSLVGHTLGAAGAIGGIATVLTLHTGQIHPTANYDDPDPACALPGISRNPQERKVKTALLNAFGFGSNNAAVVLKRYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9R9</accession>
    <name>A0A1W1I9R9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
                <ecNumber evidence="11">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="primary">ribF</name>
        <name evidence="14" type="ORF">NSJP_3573</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3573"/>
    <dbReference type="EnsemblBacteria" id="SLM49740">
        <property type="protein sequence ID" value="SLM49740"/>
        <property type="gene ID" value="NSJP_3573"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3573"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="13">
        <location>
            <begin position="183"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM49740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="313" mass="34431" checksum="80C2C49AC70263EA" modified="2017-06-07" version="1">MLMVTRGLGDAQPRPYPVATIGNFDGHHLGHRALLRTVVDAARRAGGTAMVLTFDPHPVKVLAPHVDLRFLTSPEEKLARLEAAGIDEVVFVEFSPSLASMSPEEFAESVLYRRLKVSEIFVGQHFAFGKGRAGRIADLEHYGKRFGFTVHPFTPVTSDGGVVSSTRIKQLIQTGRMEEAARLLGRWYAVTGDVIPGSQRGQALGWPTANLRLPAHRVVPPDGIYAARAMQDGATYDAVAYIGTRPTFGGGERLLEVNLLDQNRNLYGRPLTVAFVEHLREDRSFATAEALVEQIDQDAARARERLKRAEEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9T8</accession>
    <name>A0A1W1I9T8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">frr</name>
        <name evidence="6" type="ORF">NSJP_3593</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3593"/>
    <dbReference type="EnsemblBacteria" id="SLM49760">
        <property type="protein sequence ID" value="SLM49760"/>
        <property type="gene ID" value="NSJP_3593"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3593"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="5">
        <location>
            <begin position="22"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="134"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="187" mass="21190" checksum="0D07E11A20C6BBA4" modified="2017-06-07" version="1">MSNAAEIRQAVTGKMDGALEHLKRDLAGLRTGRASIALLDNVRVDYYGTMTPLRQVANLSTPEARLITIQPWEPQLIKEIEKALSVSGLGVTPSNDGKIIRVPLPPLTEERRKELTKICKKHGEDTKVHIRGFRRDANEELKKLQKDAKLTEDELRKSEADIQKLTDQYTQKIDDVIKKKEQEILEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9W0</accession>
    <name>A0A1W1I9W0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione-regulated potassium-efflux system protein KefB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3670"/>
    <dbReference type="EnsemblBacteria" id="SLM49837">
        <property type="protein sequence ID" value="SLM49837"/>
        <property type="gene ID" value="NSJP_3670"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3670"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="16"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="397" mass="43069" checksum="AB38D8DD66224F6B" modified="2017-06-07" version="1">MNPYLSLPHMVVAITLLLTISAVMIPLARWLGIGPELGLLLSGVILGSSHVLNASQVERLADISQLGVTFFLFVIGLEVDPRKVWSLRRYAFGLGTAQLIGTGLAMMLYWRFFSPSWSLALLLGLVVSNSSTALVLQLLKGKGELEQEYGQAALALLLFQDLTVVPILALLPVFAGTGSAEHFVWWDAVYAVGVMVIIYAVGRYLWPRLLHRVAGPNFEETFTAVLFIALFGSAWLASAAGLSMAMGAFIAGVSLGGSEYRHRLEGEVLPLKNLLLGLFFVSVGLTVNFNVLSGHVEKILLHIVAIVVIKIVVLYLAARAMSMQHGPAARMSFLLAQGSEFAFVVLGTLLALGTETPVQFSIGIIVVATTMVMTPWLNAIGIRWSRWDSPLVPTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9W2</accession>
    <name>A0A1W1I9W2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <shortName evidence="10">NN:DBI PRT</shortName>
            <ecNumber evidence="4 10">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">cobT</name>
        <name evidence="11" type="ORF">NSJP_3534</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CobT family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="4 10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3534"/>
    <dbReference type="EnsemblBacteria" id="SLM49701">
        <property type="protein sequence ID" value="SLM49701"/>
        <property type="gene ID" value="NSJP_3534"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3534"/>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00230">
        <property type="entry name" value="CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017846">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03160">
        <property type="entry name" value="cobT_DBIPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="7 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 11" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM49701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="351" mass="36708" checksum="302B3E43AADCC0BE" modified="2017-06-07" version="1">MTLQEAIASVRNIDDSAAAETQRRLDRLTKPQGSLGRLEELAVRYCAMTGERKPAVPRGILYTFAADHGVVDEGVSAYPRDVTAQMVRNFLRGGAGVNVLARHAGIEVRVVDIGVAHDFEVLPGLLDRKLMKSTRNMAREAAMPRDIAERACAIGVDLAAAAAGEGAGLIGTGEMGIGNTTASAAITAVMTGSVADSVTGRGTGIDERARQAKVEVIERALAFHRPDPTDAMDVLAKIGGLEIAGLAGLIVGCAAFRVPVVLDGFIAGAAALIACGLQPRCRQYLIAAHRSVEQGHDVLLKHLQLNPLLDLELRLGEGTGACLGMGLVQASVKILTEMATFGEAGVSERSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Y3</accession>
    <name>A0A1W1I9Y3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative CheW-like signal transduction protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3522"/>
    <dbReference type="EnsemblBacteria" id="SLM49689">
        <property type="protein sequence ID" value="SLM49689"/>
        <property type="gene ID" value="NSJP_3522"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3522"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="20"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="148" mass="16167" checksum="9C6A9C65AFC0C75F" modified="2017-06-07" version="1">MLRAARQQERAVATRQSWSIVVFSVGGMKLAAKAEDVGGISAWGSDVPVPSRTPFVGSLVKRDKDVLPVYDLAARLNRQRETESTLCLVTRHAEGPMAICIDAEIPSLHTVDASEVRPSRRNDIETIGSFVRDGLDIDIVALRRLGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAG4</accession>
    <name>A0A1W1IAG4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49996">
        <property type="protein sequence ID" value="SLM49996"/>
        <property type="gene ID" value="NSJP_3829"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3829"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010713380" evidence="1">
        <location>
            <begin position="28"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="322" mass="35451" checksum="3F63D82D7197DEBA" modified="2017-06-07" version="1">MRSAWRVIRQTTAFLSLSMGLLPAAWAEPVAPSVHWGAIAYPDQEQTLVAGMTFNRFTEFNGKGERFNAIQESAGLNFATVSWTERLKKFPGWSTNLTVGAGPTQANPTLYLQNDVTHQLFGNSSVPVTKEREATDFMVNGTLTRWAKLFGEREVGFMSLGFAAGSLYQEAFAQMGLRRLSLAEALEPVVGTSTFLRGFSQFVRFSGMGRYGQLFGGAAFRDATVAAQNYLGQVSMSIASYGDSDEMPPRWELEFAFTIDSGLFADPSGHSIERRLGSVALRFPYGFLETWNDGIGGTDSGPTFGFQIMIDLRRIYKQVTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAM2</accession>
    <name>A0A1W1IAM2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50056">
        <property type="protein sequence ID" value="SLM50056"/>
        <property type="gene ID" value="NSJP_3889"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3889"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="120" mass="13600" checksum="08C85FCCF4EBB383" modified="2017-06-07" version="1">MEQEQRQNQRFPVRFRSSFTSLNIVGGDGALVDLSLRGCRIDSAVEVRPGTSLELRIQVSEDEPPLRAQEAVVRWSRPRQFGLEFVTLAPEEWARLQHTVTQLELHPYQRVAADGDSQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAQ1</accession>
    <name>A0A1W1IAQ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Multi-domain non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3909</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3909"/>
    <dbReference type="EnsemblBacteria" id="SLM50076">
        <property type="protein sequence ID" value="SLM50076"/>
        <property type="gene ID" value="NSJP_3909"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3909"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="603"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1682"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1756"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1760"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="638"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM50076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1800" mass="197297" checksum="7ABE0ECC979B38C9" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAS8</accession>
    <name>A0A1W1IAS8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Iron dicitrate transmembrane sensor FecR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3933"/>
    <dbReference type="EnsemblBacteria" id="SLM50100">
        <property type="protein sequence ID" value="SLM50100"/>
        <property type="gene ID" value="NSJP_3933"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3933"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032623">
        <property type="entry name" value="FecR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16220">
        <property type="entry name" value="DUF4880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="DUF4880" evidence="2">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="1">
        <location>
            <begin position="123"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="329" mass="36691" checksum="E15E5E7C7E3D2760" modified="2017-06-07" version="1">MPSPDNQNDRPSPPEAQRLRQEAVGWLARLSDREATIEDRLAFERWQSQSPAHARAFQSIAEVWHDPGLDRAARLVARADSVHDRESLAVRSRWKPALTVAACLSALLLGAVYFEVLTRLQADHQTSVGERRTVRLPDQSLVTLNTQSAIATAFDGTVRKVRLLKGEAFFKVQHDPNRPFVVEGGETTTRAVGTEFVIRQQDHGDRVTVIEGVVDVASRSREGTKERVSAGSMIESESGRLGQARPVDASMASAWLQGLLIVDDVPLAQVLEEIRRYHPGTIVLWNQQIGQRHVTGTYKLDDPSKVLYHLTKTFPLRTVSLADRLVLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB32</accession>
    <name>A0A1W1IB32_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_4057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4057"/>
    <dbReference type="EnsemblBacteria" id="SLM50224">
        <property type="protein sequence ID" value="SLM50224"/>
        <property type="gene ID" value="NSJP_4057"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4057"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032610">
        <property type="entry name" value="DUF2172"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032589">
        <property type="entry name" value="DUF4910"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012353">
        <property type="entry name" value="UCP015244"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032622">
        <property type="entry name" value="UCP01524_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09940">
        <property type="entry name" value="DUF2172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16254">
        <property type="entry name" value="DUF4910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16221">
        <property type="entry name" value="HTH_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015244">
        <property type="entry name" value="UCP015244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DUF4910" evidence="4">
        <location>
            <begin position="18"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2172" evidence="2">
        <location>
            <begin position="68"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_47" evidence="3">
        <location>
            <begin position="356"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015244-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM50224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="435" mass="49418" checksum="AB44B23AC2DF7B29" modified="2017-06-07" version="1">MRHIRDSGEHIGVGRAMHDVLLDLFPICRSITGDGVRATLRALQKRIPLTIQEVPSGTQVFDWTVPLEWNIHDAYIKDLNGHRIIDFQKSNLHVVNYSHPINRRISLDELKNHLHSLPEHPTWIPYRTSYYKDSWGFCLSHNELQNLKDAEYDVRIDASLSKGSLSYGEFFVPGQVRDEVLFSTHVCHPSLCNDNLSGIVVTTFLAEWVLSKPRRYSYRFLFVPGTIGSITWLSQNRGQTSHIKHGLVLTGVGDPGPFTYKRSRRGDSEIDRIMANLLRHSGSPHNIVEFIPYGYDERQYCSPGFNLPVGCFSRTPHSQYPEYHTSGDSVEFVKAESLEESLEQCRTAVETLERNRVYLNRNPHCEPQLGKRGLYRGIGGQAGEKSMEMALLWVLNLSDGSHSLLEIAERADIRFEVLAAAAEKLMEHALLSPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB57</accession>
    <name>A0A1W1IB57_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">gatA</name>
        <name evidence="9" type="ORF">NSJP_4087</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4087"/>
    <dbReference type="EnsemblBacteria" id="SLM50254">
        <property type="protein sequence ID" value="SLM50254"/>
        <property type="gene ID" value="NSJP_4087"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4087"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM50254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="488" mass="52934" checksum="21328AC7BB25DF6C" modified="2017-06-07" version="1">MSIHKLSLCDLQKKFTAGEVTAVEIVRAYSLRISQVEQKVKAYVTRTTESALARAAALDEKLKTWRHTKPMMGMPLAIKDNICTSGVPTTCSSRMLKEFVPPYDATVAAKLQDQEYLLLGKTNLDEFAMGSSTENSAFGPSRNPWDLQCVPGGSSGGSAAAVAADECVAALGSDTGGSIRQPAAFCGVVGMKPTYGRVSRYGLVAFASSLDQIGPITKTVADAAYLLGAIAGHDPMDSTSADLPVPDYMKALRKRDLKKLKVGVPVEFFGEGLDPEVEQAVRAAIDELKNLGADIKEIQLPRTDAAVAVYYVIATAEASSNLARFDGVKFGLRAKETKDLLDLYMKTRQEGFGPEVKRRIMLGTYALSSGYYEAYYGKAQAVQTLIRQDFSEAFKEVDLIVTPVTPTPAFKLGAKAEDPLQMYLSDIFTISVNLAGLPAIALPCGFSKTRLPIGLQIIGRAFEEETMLRAAHAYEQSTQWHERKPVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB76</accession>
    <name>A0A1W1IB76_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cpsB</name>
        <name evidence="8" type="ORF">NSJP_4121</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-alpha-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the mannose-6-phosphate isomerase type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4121"/>
    <dbReference type="EnsemblBacteria" id="SLM50288">
        <property type="protein sequence ID" value="SLM50288"/>
        <property type="gene ID" value="NSJP_4121"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4121"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006375">
        <property type="entry name" value="Man1P_GuaTrfase/Man6P_Isoase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01479">
        <property type="entry name" value="GMP_PMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP_isomer" evidence="7">
        <location>
            <begin position="325"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM50288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="483" mass="53665" checksum="47DD6E51EF1F4905" modified="2017-06-07" version="1">MKNRAAVYPVIMAGGSGTRFWPLSRHLFPKQLLRIIGDETLIQQTMRRVVHGAPAQQVLISTNPAQAESIRIQLVEWKDEIKDNFVLEPEGRNTAPAIALAALELVRRDPDAVMLVVPADHIVKGQKEFDAAVKLAAELAGQGYLVTFGIKPIRPETGYGYIKPNKRITVGKQGKLKGHPVSRFVEKPNAVKAAQYVKAKDYYWNSGMFVWRAATILEEIRHHQPALFKGIERIRELMQAGGMRGAIDEEYKKLAPVSVDTGVMERSTKSAVVPVAFEWSDVGSWGSLDEVAPKDKAGNIVGGRVVDLGSRRSVVYGDRRVVATIGLTDMVVVDTPDATLVCPKDRAQDVKKVVDILKQQGAPEHLEHVTVHRPWGSYTILEEGDGYKVKRVTVKPGGRLSLQMHHRRSEHWVVIAGTARVTRGDDVFDLQVGQSTAIPVETRHRLENFGQETLHIIEVQNGPYLGEDDIVRFKDEYGRTAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBN1</accession>
    <name>A0A1W1IBN1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Asparagine synthetase</fullName>
            <ecNumber evidence="8">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_4144</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50311">
        <property type="protein sequence ID" value="SLM50311"/>
        <property type="gene ID" value="NSJP_4144"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4144"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="7">
        <location>
            <begin position="2"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="369"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM50311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="634" mass="73147" checksum="41B54B1B4EC70DDA" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZP5</accession>
    <name>A0A1W1HZP5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_0054</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0054"/>
    <dbReference type="EnsemblBacteria" id="SLM46226">
        <property type="protein sequence ID" value="SLM46226"/>
        <property type="gene ID" value="NSJP_0054"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0054"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="10">
        <location>
            <begin position="62"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM46226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="303" mass="33230" checksum="9190A0972AC82803" modified="2017-06-07" version="1">MGPGMRTLYYLLREAWVNLRTNRTTTMVAILTTAFTLACVGVFLLLYVNLRAAAGWLQDDIKIIVYLDDHLSSDARADLEQQLRGDHAVAAIHFVSKEQALGEFKDQFPSESHLLEGLGQNPLPASFVVTLGPAFRSLDAVKRWSERVQGMTDVAKVDYNQDWIDALAMVIRSIELVAIGIGVILSAAAVTIIANTIRLTLLARRDEIAILRLIGATTGFIRIPYLLEGAVLGGLGSAISLFMLKLLYELFRREMRTSGKLSGLDNLLAFFPMPLCLALIVVGMALGCAGSFVSLRRFDEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZQ0</accession>
    <name>A0A1W1HZQ0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0030"/>
    <dbReference type="EnsemblBacteria" id="SLM46202">
        <property type="protein sequence ID" value="SLM46202"/>
        <property type="gene ID" value="NSJP_0030"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0030"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="150"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="335" mass="35830" checksum="8FD7E4DF13C16E76" modified="2017-06-07" version="1">MSDSIENVAELEACIGKVPGPIDLKVIDHLDDGARRWIAASPLLFAAFGDGRNVGMTLGGGEQGFVQVLDASRLRLPAAALDELQLAREGLGFGALFLTPSIGETLRVGGRVAAVKGGEVEIHVDECYVHCAKALIRSKFWEAPAHHQMPDDAPDFVAASRFMALATVDAKGHADVSPKGDPQDMLIRLRQGCAWIADRPGNRRADSFRNMLTQPHVAAALLIPGCTKVALLSGRARITTDAAVRTDLSVAGKMPILLTCIEQPALSIRESAALTRAGLWPAKPRAEGIDSAAMFVAHIKHSKARGLQAKLARAAVSVPGIMEKGLQRDYRKNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Q6</accession>
    <name>A0A1W1I0Q6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ferric uptake regulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fur</name>
        <name evidence="4" type="ORF">NSJP_0399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46571">
        <property type="protein sequence ID" value="SLM46571"/>
        <property type="gene ID" value="NSJP_0399"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0399"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="159" mass="18853" checksum="DA9A287056380CBC" modified="2017-06-07" version="1">MPRSPKLRSVNRLEEARRLLSAYERQHRLKRSQVRETILAAFAKHDHVTARTLFHHFLRQQRRFGLATIYKNMNLFCRAGIAQAHRFGTQMHYDHVTLTGQHDHLLCTDCRGIWEFHNPDIAKHARAVAQRNGFFLGRQRLELYGLCADCWDRRHPTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Q9</accession>
    <name>A0A1W1I0Q9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46564">
        <property type="protein sequence ID" value="SLM46564"/>
        <property type="gene ID" value="NSJP_0392"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0392"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="56" mass="6031" checksum="808738C7F56E55F8" modified="2017-06-07" version="1">MTEGEYNAYTVSGIFLPSSCSSVLAQKTMETLIVNIIYHGDGGLTHFNSGGLTWSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0S4</accession>
    <name>A0A1W1I0S4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ysc84 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0281"/>
    <dbReference type="EnsemblBacteria" id="SLM46453">
        <property type="protein sequence ID" value="SLM46453"/>
        <property type="gene ID" value="NSJP_0281"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0281"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84" evidence="1">
        <location>
            <begin position="103"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="191" mass="20292" checksum="9A752C2B9BC23134" modified="2017-06-07" version="1">MMRKQVSCGVQFVTMLGVSIFMFVGLFGGSALAASGKEIDAGVDEAIGKFEKEVKGGKSFLDGSKGLLVFPRVLKGGAGFGGEYGEGALRIAGKTTDYYNMFQGSFGLQLGGEIKTVYLVFLDEVALKRFRESEGWKAGVDGSVSLVTLGAGGTIDTNNLKEPIVAFVLGQKGLMYNLSLEGTKFTKQDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0T4</accession>
    <name>A0A1W1I0T4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46618">
        <property type="protein sequence ID" value="SLM46618"/>
        <property type="gene ID" value="NSJP_0446"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0446"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="47" mass="5130" checksum="1015FA5B167E9749" modified="2017-06-07" version="1">MQIMTPSYEGDPESPKVVSKDRWFAAPAMAPVQPSSSEEISRVSHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0V2</accession>
    <name>A0A1W1I0V2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46607">
        <property type="protein sequence ID" value="SLM46607"/>
        <property type="gene ID" value="NSJP_0435"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0435"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="67" mass="7426" checksum="6F53ED93ECE9EFB7" modified="2017-06-07" version="1">MISTTNLLFLFTVATDRVGMSHQLRRNSSKELSNTPATVNVMTELISIPPQIDNAPGRLTKIRTNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0V6</accession>
    <name>A0A1W1I0V6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46638">
        <property type="protein sequence ID" value="SLM46638"/>
        <property type="gene ID" value="NSJP_0466"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0466"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="170" mass="18741" checksum="8F05E0110B22C7AA" modified="2017-06-07" version="1">MISSKVYRKVPWLAGGAVSWTLCLLVVMAWAANDPAPSVLWREVSDQASPGRPFPPKKPWVIREREIVFDPELLTLLKNAAARPLPPIAIALFHGPSYELDVSSSLARLSDVSTVRGSLKHAPKSSWSLIISGNVVNGTVQVGDRLYKIEHVFNGRHRLLEIDPAKMPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I132</accession>
    <name>A0A1W1I132_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46543">
        <property type="protein sequence ID" value="SLM46543"/>
        <property type="gene ID" value="NSJP_0371"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0371"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="48" mass="5777" checksum="6B8230845530FDCB" modified="2017-06-07" version="1">MPSSIGSESPYDHSLAIKKSWQDQYQFIRILRRMEKFIKLSSFMRNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1F2</accession>
    <name>A0A1W1I1F2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46812">
        <property type="protein sequence ID" value="SLM46812"/>
        <property type="gene ID" value="NSJP_0640"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0640"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="30" mass="3303" checksum="0F775F039D96A5E7" modified="2017-06-07" version="1">MTNLTPCIVALGGFLLCRLILPIARVFEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1G0</accession>
    <name>A0A1W1I1G0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Low molecular weight protein-tyrosine-phosphatase Wzb (Modular protein)</fullName>
            <ecNumber evidence="5">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_0649</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46821">
        <property type="protein sequence ID" value="SLM46821"/>
        <property type="gene ID" value="NSJP_0649"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0649"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="LMWPc" evidence="4">
        <location>
            <begin position="67"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="225" mass="25570" checksum="82DFBFC891B04889" modified="2017-06-07" version="1">MLIERLETVDQVLRRVIRKVVYLTLIVPLRALTGLLHILRVKVLRRIAIWMWRQDDTIIANRPRPVHSVFFVCKGNICRSPLAEAYMKSKLKGKNQLRVFSGGLDTTPGHTANAVAETIARQYGLALEGHRTTPISRDLIRQADLILVMDYSQRQSLLATYPEAQGKVSLLSSFRRGVLTHIPDPYGGTLEQFDHCYQLISQSCDNLLTYIEIPESASLHERSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1I4</accession>
    <name>A0A1W1I1I4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alginate_exp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0704"/>
    <dbReference type="EnsemblBacteria" id="SLM46876">
        <property type="protein sequence ID" value="SLM46876"/>
        <property type="gene ID" value="NSJP_0704"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0704"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025388">
        <property type="entry name" value="Alginate_export_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13372">
        <property type="entry name" value="Alginate_exp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012370778" description="Alginate_exp domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate_exp" evidence="2">
        <location>
            <begin position="194"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="571" mass="62658" checksum="3870C10F01070605" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1P2</accession>
    <name>A0A1W1I1P2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">mutS</name>
        <name evidence="11" type="ORF">NSJP_0756</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0756"/>
    <dbReference type="EnsemblBacteria" id="SLM46928">
        <property type="protein sequence ID" value="SLM46928"/>
        <property type="gene ID" value="NSJP_0756"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0756"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="10">
        <location>
            <begin position="711"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="824"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="637"/>
            <end position="644"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM46928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="882" mass="97788" checksum="840529FEF9DAC856" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1S1</accession>
    <name>A0A1W1I1S1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rpsO</name>
        <name evidence="7" type="ORF">NSJP_0762</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0762"/>
    <dbReference type="EnsemblBacteria" id="SLM46934">
        <property type="protein sequence ID" value="SLM46934"/>
        <property type="gene ID" value="NSJP_0762"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0762"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="89" mass="10562" checksum="1C34ECA424536C96" modified="2017-06-07" version="1">MALLKEAKTELIKQYRQHDGDSGSPEVQIAVLTNRISYLTEHFKLHKKDHHSRRGLLQLVGRRRRLLDYLRDVDEARYRAVIDRLGIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Y3</accession>
    <name>A0A1W1I1Y3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47020">
        <property type="protein sequence ID" value="SLM47020"/>
        <property type="gene ID" value="NSJP_0848"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0848"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="97" mass="10917" checksum="F4BB91D0E040BCEE" modified="2017-06-07" version="1">MFPAVMHNCPVNHRLRVCIVGAALADCLAQRFILLALRSEEGVRTDGTETRNRTYLLRSGDYPGRDLLGYRRTGHSLQSTPRALWQPDQATAILPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I219</accession>
    <name>A0A1W1I219_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GspH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_0737</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0737"/>
    <dbReference type="EnsemblBacteria" id="SLM46909">
        <property type="protein sequence ID" value="SLM46909"/>
        <property type="gene ID" value="NSJP_0737"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0737"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022346">
        <property type="entry name" value="T2SS_GspH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12019">
        <property type="entry name" value="GspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="GspH" evidence="10">
        <location>
            <begin position="52"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM46909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="153" mass="16484" checksum="B1699EB84B0D1E7A" modified="2017-06-07" version="1">MPSVHVLRPNAQERGASLTEVLMVMVILALVAALAGPSYKAAIARAQARSVAAEIASGLRLTRQLAMSRRERLLVQFDQARRALTFMRADSGDVLDEYQYADKGVMLDVPSAGPNVLFYPSGRSATATTIAIVDHMGRRITLTVSITGRVSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I239</accession>
    <name>A0A1W1I239_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46929">
        <property type="protein sequence ID" value="SLM46929"/>
        <property type="gene ID" value="NSJP_0757"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0757"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="24" mass="2650" checksum="5D9B713B54D06585" modified="2017-06-07" version="1">MRMLLGIGCALLEISETIQCIERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I246</accession>
    <name>A0A1W1I246_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">kdpD</name>
        <name evidence="9" type="ORF">NSJP_0890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47062">
        <property type="protein sequence ID" value="SLM47062"/>
        <property type="gene ID" value="NSJP_0890"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0890"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="671"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="900" mass="99709" checksum="D0F85C661BA981E7" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I253</accession>
    <name>A0A1W1I253_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Hydrolase with N-terminal DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0900"/>
    <dbReference type="EnsemblBacteria" id="SLM47072">
        <property type="protein sequence ID" value="SLM47072"/>
        <property type="gene ID" value="NSJP_0900"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0900"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="280" mass="30248" checksum="C11837E4617CEA82" modified="2017-06-07" version="1">MPLEDDLSDILKKARGGLGLSVREVAVASGLSEADVTGLERGHKPPDRRTVRALAGVLALKPDPLVGMAIENWRPADRQKLPWVETVYGSVGGYGVQGYLLHDDGEALIVDTGYNAPAMISALNERRLRLVGICLTHGHSDHARGIEELLAHREVPVYLGNDDRSLLDWRPRAGLLTSPHDGLVVRVGARTVRCLATPGHTAGGICYQADDQEQPTCFVGDTLFAGSIGRSNPFTLYETHLDSVRRRLLTLPGDVRLLPGHGPGTTVAEEREHNPFASLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I281</accession>
    <name>A0A1W1I281_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetoacetate metabolism regulatory protein AtoC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">atoC</name>
        <name evidence="8" type="ORF">NSJP_0948</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0948"/>
    <dbReference type="EnsemblBacteria" id="SLM47120">
        <property type="protein sequence ID" value="SLM47120"/>
        <property type="gene ID" value="NSJP_0948"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0948"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="12"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="156"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="473" mass="53343" checksum="CAE58270944115A5" modified="2017-06-07" version="1">MSIKPVTDKIFTILLVEDNGGDVEVFLRTVEAELPREADEQVDLVIAARAEGALKVLEDRRIDLVITEVRLPGMSGIELLQRIQARDRRIPVIVISRVGTVDTAVEAMRCGAFDYVTKPFERLDLAARIHRAMRISEILFRYEPPQKGEPQTFKELIGVSPAIRNVTALIEAAARVQSTTLIIGETGTGKELIARAIHERSAERDGPFQVVDCTTFSEGTVESELFGHVRGAFTGAVGDKLGLIERGIGGTLFLDEIGDLPLPLQAKLLRVLEEGEMRAVGSVQMKKVSARFIAATNQELTEKVKRNEFRKDLFFRLNVMAIRVPPLRERSQDIPLLARHFMSRYTKEFGKYVNELHPSAVTELVAYPWPGNVRELRNVMERAVMLANGDRISQEDVIGLLQFTDQAKRAQGDDYLSLPYAKAKEKVLEDFSRRYIKSKLDHHQGNVTHAAQEAGLPRSYFHEIMRRYLRDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2A8</accession>
    <name>A0A1W1I2A8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0781"/>
    <dbReference type="EnsemblBacteria" id="SLM46953">
        <property type="protein sequence ID" value="SLM46953"/>
        <property type="gene ID" value="NSJP_0781"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0781"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="254" mass="27275" checksum="B286623AA6A07349" modified="2017-06-07" version="1">MSDGEMPDRIDQLISALRDDNEALRDHAIASLSQVGEEAIGPLIGLMADEDVLIREAATTAVVRIGPAAVDRLIDAVEDDEWAIREQAASGLGKLKDPRGVEPLVKALKDKDGAVRTAAVWALERIGDSRAVPGLVDALTDSTLREDVARVLKKIGDSRAVDALIEGLLGNNWMVRRHAAEALGKIGDHRGVGPLIESLKDEDWLVRRNAAESLARLGAKQAIDPLLPLLEDENTMVQETVEGVLASLGWKSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2B6</accession>
    <name>A0A1W1I2B6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Nitrate oxidoreductase, alpha subunit</fullName>
            <ecNumber evidence="6">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nxrA</name>
        <name evidence="6" type="ORF">NSJP_0949</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.4" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0949"/>
    <dbReference type="EnsemblBacteria" id="SLM47121">
        <property type="protein sequence ID" value="SLM47121"/>
        <property type="gene ID" value="NSJP_0949"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0949"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="64"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1148" mass="131679" checksum="ED586636D865EAEF" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2C2</accession>
    <name>A0A1W1I2C2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0973"/>
    <dbReference type="EnsemblBacteria" id="SLM47145">
        <property type="protein sequence ID" value="SLM47145"/>
        <property type="gene ID" value="NSJP_0973"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0973"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041164">
        <property type="entry name" value="LDcluster4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18306">
        <property type="entry name" value="LDcluster4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="177" mass="18715" checksum="D1D932686E1A77EF" modified="2017-06-07" version="1">MRYIVGVMGPAKARKKDIENARALGELIARREWVLLTGGRDVGVMHAASQGAKKVARSLTVGVLPSTRDRVSKYVDVAVITEMGNARNNVCVLSSQVIVACGLGGSGTVSEVALALKAGKSVILLGATPVEDKFFKNLGGKLVSSVQTPEDAINVILKRLERDDSQGMQGPNPWAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2C6</accession>
    <name>A0A1W1I2C6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47019">
        <property type="protein sequence ID" value="SLM47019"/>
        <property type="gene ID" value="NSJP_0847"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0847"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012912923" evidence="2">
        <location>
            <begin position="23"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="89" mass="9394" checksum="1CA5BEF405A3E29B" modified="2017-06-07" version="1">MRTLMCAFALVASLGVAIPTMAGETSATMEKMKGETKALGEEAKGQTKGAVEDLKGNKTKAEMERAKGSAKGDMERAKGKVNETIEKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2K9</accession>
    <name>A0A1W1I2K9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47250">
        <property type="protein sequence ID" value="SLM47250"/>
        <property type="gene ID" value="NSJP_1078"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1078"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="250" mass="26929" checksum="373CAD27C690E013" modified="2017-06-07" version="1">MTPLSLWRIGREHDHHPLILAILVLTTLEFSTTQEDVATASDCLTAEFTGSWPTLAFPARSSLRLWNLPPIVSLQDALKYFPTAPACGLPPTLSAGLSTRAGIRDQAIVTPDAAVGQGSRTTITANSAATTGRRTMKTTSRIPTVKIGIPPLSGKTHTFRTWTTPIELEPQTGERPSGFIGPNNQTRPNQHTAPNVFPPAPLVQSERRPVDLSIPLRHVLPQADYDAESNRMNSATALALHGGECAYACP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2S2</accession>
    <name>A0A1W1I2S2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHASE3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47123">
        <property type="protein sequence ID" value="SLM47123"/>
        <property type="gene ID" value="NSJP_0951"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0951"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007891">
        <property type="entry name" value="CHASE3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05227">
        <property type="entry name" value="CHASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="CHASE3" evidence="2">
        <location>
            <begin position="46"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="214" mass="24106" checksum="20E949E710038866" modified="2017-06-07" version="1">MARRSKLWAYLGAGIVLIVIFSIEQMMLLRQWQDNIVSQQQRSAIREEVLILRRWTSDIDNGFRGYVLVRQPYFLAPMVMAEEEIPMALERLTRLTGSTPALQGSVQVLKRRLDELITTKRKLATKIANGESEEVLAYVRAGEGLALAKTISAVFDDFETKIARQFPEADLTPLERQKKTLWQLVAAQAGAVFVGVLVMELLLAAFAAPQRSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Y5</accession>
    <name>A0A1W1I2Y5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Ribonuclease BN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1195"/>
    <dbReference type="EnsemblBacteria" id="SLM47367">
        <property type="protein sequence ID" value="SLM47367"/>
        <property type="gene ID" value="NSJP_1195"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1195"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="314" mass="34602" checksum="EA78423026A1663E" modified="2017-06-07" version="1">MSRTSDMASVTSSSAAYNPWKLGGLTLTDLGRRLWREAQEDELLGRAAQLSYYALLALFPALMFLTALMGLFSVEDFMPELMRYLRNVLPTDALSMVERFLIQVAEGSGANLLSLGALGALWASSSGMTAIIDALDVVYDVRQDSRPFWKIRLTALLLTVGLAGFVIFSIALVLYGPSIGRWIADALGVGMIFTWMWTVLQWPVVVTLMLFVVAVIYYTCPDIKQDWRWVTPGAVFAVAMWVVMSLGFKAYVEHFGDYNKVYGSIAGVIVLMLWLYWSGLALLIGGEINAEIEDAATERQGRPPTGLHGAPHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I357</accession>
    <name>A0A1W1I357_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47424">
        <property type="protein sequence ID" value="SLM47424"/>
        <property type="gene ID" value="NSJP_1252"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1252"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="588"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="647" mass="70527" checksum="E7C50F5352D3D8AF" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I377</accession>
    <name>A0A1W1I377_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47452">
        <property type="protein sequence ID" value="SLM47452"/>
        <property type="gene ID" value="NSJP_1280"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1280"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="103" mass="11542" checksum="7BA5B927B73916C8" modified="2017-06-07" version="1">MIERRYQRFPVSLPCALMAHDGPHITRSVDLSKKGCRIQNTVRVAPNTVIDLLLFTGEDLPIAIPAANVRWCGADGIGIEFQALASYHQQRLNLLLNQLQKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I381</accession>
    <name>A0A1W1I381_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47466">
        <property type="protein sequence ID" value="SLM47466"/>
        <property type="gene ID" value="NSJP_1294"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1294"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="307" mass="33420" checksum="9731B3C0586CA0EE" modified="2017-06-07" version="1">MTIPTASFRPSPFIGLSRFLCLLFISAMTLLPGGPTAAWARPPSWEQVADGLRVTLWTTPCPDVPPLILIAIDPRRYRFSVHYYRNEGLAQPPDIHEWQTRTGHDLVFNAGLFRENFAYLGLLFGNGMSLGGKQHGTWLGLFVAEPTRAGDPPAKILDLAVESFDVRELPYQEAAQSLMLLDENGTVRVRRSGKQAQQTILAEEIGGPMLVVKTTQPATLFDIGQCLHEEFPTIRRAMAMDGGSSSDVALGPVLRRNATHADLGAGWMPFFADTGSGHIGLPAVIGISPRHSSAPATKTPPRKSATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3C4</accession>
    <name>A0A1W1I3C4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47379">
        <property type="protein sequence ID" value="SLM47379"/>
        <property type="gene ID" value="NSJP_1207"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1207"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="59" mass="6425" checksum="E311635596D6E824" modified="2017-06-07" version="1">MMDSFPCNAAPSPFRDGAAQVQVTIRNDCKLLGWLQVQQGLLGMTRVRSLGLAMCLLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3X0</accession>
    <name>A0A1W1I3X0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">folK</name>
        <name evidence="10" type="ORF">NSJP_1545</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1545"/>
    <dbReference type="EnsemblBacteria" id="SLM47717">
        <property type="protein sequence ID" value="SLM47717"/>
        <property type="gene ID" value="NSJP_1545"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1545"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="9">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="184" mass="20479" checksum="FC2BCD316C5E1CA5" modified="2017-06-07" version="1">MSETVYIGFGSNVGNRIDLCDRAVTLLSLLPHSRLSGVSLLYETEPVQDGAHPGEGWFLNGVVQIETDITPHSLLSVLREIERSLGRDESDRAGPRTIDLDLLFYGDRVIDEPGLRVPHPRLHQRRFVLIPLNELDPLLVHPTMGQTVSRLLSDVKDSSDVRLLFPQPSTRYGSRPSCSPPPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I465</accession>
    <name>A0A1W1I465_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-quinone oxidoreductase subunit L</fullName>
            <ecNumber evidence="9">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nuoL</name>
        <name evidence="9" type="ORF">NSJP_1624</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1624"/>
    <dbReference type="EnsemblBacteria" id="SLM47796">
        <property type="protein sequence ID" value="SLM47796"/>
        <property type="gene ID" value="NSJP_1624"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1624"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="613"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="8">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="129"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="631" mass="68077" checksum="5266DC98A2E7BC7D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I476</accession>
    <name>A0A1W1I476_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxythreonine-4-phosphate dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.262</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">4-(phosphohydroxy)-L-threonine dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">pdxA</name>
        <name evidence="5" type="ORF">NSJP_1579</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>4-(phosphooxy)-L-threonine + NAD(+) = 3-amino-2-oxopropyl phosphate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32275"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="EC" id="1.1.1.262"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="4">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="4">The active site is located at the dimer interface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PdxA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.262" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1579"/>
    <dbReference type="EnsemblBacteria" id="SLM47751">
        <property type="protein sequence ID" value="SLM47751"/>
        <property type="gene ID" value="NSJP_1579"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1579"/>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050570">
        <property type="term" value="F:4-hydroxythreonine-4-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00536">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037510">
        <property type="entry name" value="PdxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005255">
        <property type="entry name" value="PdxA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30004">
        <property type="entry name" value="PTHR30004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04166">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00557">
        <property type="entry name" value="pdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="353" mass="36842" checksum="08F96B79EC3F3EF9" modified="2017-06-07" version="1">MGSRKASGAGRKRIRSESKPLLGITMGDPAGIGPEVIAKALAQPRVRRLCLPLVIGSQSIMRQTVKRLGLRLDVVAVDGHGGAAFRAGQISVLDPAEQPLSRVKPGVASSEGGAASVAFIKKGVRLAQLGCIDGIVTAPINKEAINMAGCHFPGHTELLADLTKAKESGMMIVGGPLKIMFVTTHLAIKDLPAQLTRPKIEKGIRLAHMALTRLFGFKRPRIGVAALNPHAGEHGLFGDEEGRLVLPAARAARAKGILASDPLPADTLFGKAARGEYDGVVALYHDQGLIPLKLVAFGTCVNLTVGLPIIRTSVDHGTAFDIVGKGVADPGSLVEAIVLAAGLAARRQRAQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4D6</accession>
    <name>A0A1W1I4D6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-quinone oxidoreductase</fullName>
            <ecNumber evidence="10">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NSJP_1629</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="10">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1629"/>
    <dbReference type="EnsemblBacteria" id="SLM47801">
        <property type="protein sequence ID" value="SLM47801"/>
        <property type="gene ID" value="NSJP_1629"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1629"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 9 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0874">Quinone</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="11">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="14">
        <location>
            <begin position="84"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="221"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SLM47801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="895" mass="96617" checksum="98B196749D6DFC8A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4D9</accession>
    <name>A0A1W1I4D9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADP-L-glycero-D-manno-heptose-6-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">ADP-L-glycero-beta-D-manno-heptose-6-epimerase</fullName>
            <shortName evidence="3">ADP-glyceromanno-heptose 6-epimerase</shortName>
            <shortName evidence="3">ADP-hep 6-epimerase</shortName>
            <shortName evidence="3">AGME</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">hldD</name>
        <name evidence="5" type="ORF">NSJP_1673</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose</text>
            <dbReference type="Rhea" id="RHEA:17577"/>
            <dbReference type="ChEBI" id="CHEBI:59967"/>
            <dbReference type="ChEBI" id="CHEBI:61506"/>
            <dbReference type="EC" id="5.1.3.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
        <text evidence="3">Binds 1 NADP(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homopentamer.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.20" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47845">
        <property type="protein sequence ID" value="SLM47845"/>
        <property type="gene ID" value="NSJP_1673"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1673"/>
    <dbReference type="UniPathway" id="UPA00356">
        <property type="reaction ID" value="UER00440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008712">
        <property type="term" value="F:ADP-glyceromanno-heptose 6-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097171">
        <property type="term" value="P:ADP-L-glycero-beta-D-manno-heptose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05248">
        <property type="entry name" value="ADP_GME_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01601">
        <property type="entry name" value="Heptose_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011912">
        <property type="entry name" value="Heptose_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02197">
        <property type="entry name" value="heptose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="215"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="88"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="359" mass="40290" checksum="B1DC3D5B39F5388C" modified="2017-06-07" version="1">MSSNGKTDLCLDGSRVLVTGWAGFIGSALIWGLNLRGCDDIVVVDRLRRSDKWRHLAPLRFRDYLEADELLPRLQAGTLGQFDLVVHLGACSSTSESDVAYLIHNNFEFTKTLCHWTLNAKGRFVYASSAATYGDGQQGMSDMDRDLDKLRPLNAYGFSKQLFDRYAWRNGLLDRIVGLKYFNVFGPNEDHKGDMRSVVNKATQQAQATGRVELFKSYRPEYRDGQQKRDFLYVKDAVDMTLHLAEKSQTAGLFNIGSGVAHSWLELTAAVFKALERKPAIDFIDMPTDLRPKYQYFTQAAIEKLRATGYTRPITPLHDAVQDYVVNYLMPGALLDSGVGLTLSKPQKSDSPVGSFQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4E2</accession>
    <name>A0A1W1I4E2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47683">
        <property type="protein sequence ID" value="SLM47683"/>
        <property type="gene ID" value="NSJP_1511"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1511"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="52" mass="6217" checksum="DCDDBEB8C07CE9C9" modified="2017-06-07" version="1">MTIASSNFDDTVEYPIDQHSLAKLQDPHLTTEGFQRIYHQLTWPPKEIQRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4H3</accession>
    <name>A0A1W1I4H3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1703"/>
    <dbReference type="EnsemblBacteria" id="SLM47875">
        <property type="protein sequence ID" value="SLM47875"/>
        <property type="gene ID" value="NSJP_1703"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1703"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039543">
        <property type="entry name" value="POX18/UbiT/NSL-TP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="PTHR10094"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="111" mass="11908" checksum="08D93A33EB097C82" modified="2017-06-07" version="1">MKPPTLKEFFRHLPEKLDTDAAEGLEAVYQFDLSGIEGGNYFLTVSQGACRVNEGKHDDPHVTLAMAGEDCIKVLTGQLSGQMAAMSGKLRIMGDLGLALQLRALFPGIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4M8</accession>
    <name>A0A1W1I4M8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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        <property type="gene ID" value="NSJP_1601"/>
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    <dbReference type="KEGG" id="nja:NSJP_1601"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
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    </dbReference>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="528"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="835" mass="91345" checksum="CEEB9CDA3E67E076" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4N2</accession>
    <name>A0A1W1I4N2_9BACT</name>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
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            <begin position="217"/>
            <end position="254"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="SLM47962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="254" mass="27724" checksum="27EB0A042CF9C65A" modified="2017-06-07" version="1">MATTPDTREKIIVPGPAGFHPPSAAQLGVALPDPGQGLYYGLLEPNEEKVIEEMARKMLTSPNATIFPGPLLLWAWNDHAVEKAKATLEIAAQIPEVMIIPMPDYRPKYPKIDPEEVINPNHPNLTIWGNKIEACIFIGVHCHYANLTLKMIRAGTNCCTMAICAEQGHEDAMLTIRDSDTAKIKRVAQIFKKVREEMGIKLPESGENVRFTGTQSKVHDGKTHTNPAAFAPTPGGAGSAAMFGHSAEHMKREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4P5</accession>
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        <name type="scientific">Nitrospira japonica</name>
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        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="Virul_fac_BrkB"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Virul_fac_BrkB"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="yihY_not_rbn"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="21"/>
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        </location>
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            <begin position="54"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="207"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="286" mass="31792" checksum="EF124F0E3468AD33" modified="2017-06-07" version="1">MTILPLIGSLIRSFLRHGCGSLAASLAFFSLLSLFPLVFLLLYGVSFVVSHDVIGGQVLLSFLKGFLPILGARLAEELQRVAEMETVRWLVFLSFAWFGTLVFYELDYTLNVVFDSTRQRHPLISIVISVALLGAASLLLIVSYVATQSVNILVANAPRLWGLDFLALAAHDFFLTYTLPFALAFLTVTVVYRYVPRRRPAWREAMIGALTFSLLWVSAKLIFVTYRDYATVYTDLYGSLLEVVLLLLWLYYSASLFLFGAVVARSLQPRLQTVGPAAANPSSSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4T9</accession>
    <name>A0A1W1I4T9_9BACT</name>
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        <submittedName>
            <fullName evidence="13">Putative Quinol-cytochrome c reductase, cytochrome b subunit</fullName>
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        </submittedName>
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    <gene>
        <name evidence="13" type="ORF">NSJP_1852</name>
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        <name type="scientific">Nitrospira japonica</name>
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            <taxon>Bacteria</taxon>
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    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.10.2.2" evidence="13"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1852"/>
    <dbReference type="EnsemblBacteria" id="SLM48024">
        <property type="protein sequence ID" value="SLM48024"/>
        <property type="gene ID" value="NSJP_1852"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1852"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_b/b6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036150">
        <property type="entry name" value="Cyt_b/b6_C_sf"/>
    </dbReference>
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        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00032">
        <property type="entry name" value="Cytochrom_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00033">
        <property type="entry name" value="Cytochrome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81648">
        <property type="entry name" value="SSF81648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51003">
        <property type="entry name" value="CYTB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="11">
        <location>
            <begin position="17"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_CTER" evidence="12">
        <location>
            <begin position="232"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM48024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="370" mass="41685" checksum="BCB94DB2DB6BCA70" modified="2017-06-07" version="1">MEHSPIPSSQPTAIEKVVAFIDERVGLKQMQAKMLNEPVPGGSRWAYVFGSVLLFIFIMQAVTGILLMFYYVPTADHAYASTQYILHDVDYGWFLLSYHFWGSTAMVVCVFAHMSQVFLWGAYKSPREMIWLVGLALFGIVMGFGFTGYLLPWDQRAYWATTVGVEIMDKTPLLGDFMARFLKGGPTPGQMTLSRFFVIHVMILPAALMGLAGLHLFLFRAAGPAGPFRGTPEELKAKTDYFFPRQIWKDIVGMVIVFACICALAFWEPVVLLEEATPDPGDYHPEPEWYFLFLFQLLRLKIFAGEFGQFLGAIALPGAFMALLAALPFIDKDPERNIFKRPIALIGWIVVMVSILLFTVSAIINREFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I553</accession>
    <name>A0A1W1I553_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative metal chaperone YciC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yciC</name>
        <name evidence="3" type="ORF">NSJP_1879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1879"/>
    <dbReference type="EnsemblBacteria" id="SLM48051">
        <property type="protein sequence ID" value="SLM48051"/>
        <property type="gene ID" value="NSJP_1879"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1879"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="266"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="414" mass="46795" checksum="D03D3D57B6694ADB" modified="2017-06-07" version="1">MERYVQPQPNDMRLPVTVLSGFLGAGKTTLLNHMLHNREGFRVAVIVNDMSEVNIDAALILQGGAALSRTDEQLVEMSNGCICCTLREDLLKEVARLAAERRFDYLLIESTGISEPMPVAETFRFQDETGRSLSTVARLDTMATVIDAQNFLRDYRQAEDLKLRGLALGEEDERTITDLLIDQVEFANVLVINKIDLISEEELKELSAILAKLNPDARILHVKYGHVQVSALLNTRLFDFELASQAAGWMKTLRGEESSETDEYGITSFVYRARRPFHPIRWWKLLQQNWAGVLRTKGMFWIATRPDLIGLWSQAGGTGSVRWIGRWYASMPKAQWPSDEEEAQRIHGLWDQEFGDRTQELVVIGRKMDQAVLTAMLDACLVTSVEWTDPVSWKTATDPFPPAGHDLETTVVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I565</accession>
    <name>A0A1W1I565_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Depupylase</fullName>
            <ecNumber evidence="1">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dop</name>
        <name evidence="1" type="ORF">NSJP_1982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.-.-" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1982"/>
    <dbReference type="EnsemblBacteria" id="SLM48154">
        <property type="protein sequence ID" value="SLM48154"/>
        <property type="gene ID" value="NSJP_1982"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1982"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="515" mass="58103" checksum="766189E9030D9AF3" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5G1</accession>
    <name>A0A1W1I5G1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48244">
        <property type="protein sequence ID" value="SLM48244"/>
        <property type="gene ID" value="NSJP_2072"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2072"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="59" mass="6320" checksum="361E9CE759DBB527" modified="2017-06-07" version="1">MGSFCLRSVSCPNGKQVDYSHCVSGQCSPDHPCPVGYLCVRYSEGVSYCIPEPVCTDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5U8</accession>
    <name>A0A1W1I5U8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidoglycan glycosyltransferase RodA</fullName>
            <shortName evidence="6">PGT</shortName>
            <ecNumber evidence="6">2.4.1.129</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cell elongation protein RodA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Cell wall polymerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Peptidoglycan polymerase</fullName>
            <shortName evidence="6">PG polymerase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mrdB</name>
        <name evidence="6" type="synonym">rodA</name>
        <name evidence="7" type="ORF">NSJP_2031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Peptidoglycan polymerase that is essential for cell wall elongation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SEDS family. MrdB/RodA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2031"/>
    <dbReference type="EnsemblBacteria" id="SLM48203">
        <property type="protein sequence ID" value="SLM48203"/>
        <property type="gene ID" value="NSJP_2031"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2031"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02079">
        <property type="entry name" value="PGT_RodA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02210">
        <property type="entry name" value="rodA_shape"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="372" mass="41325" checksum="04362F50C31F9582" modified="2017-06-07" version="1">MIDRVIESRQFDNFDLRFLGLVFLILGIGVLSIYSVTHDQGGSMPFFAKQLVWILLGSVAFFIMQIWDYHRIARWAYPAYAVILLLLAFVLFEGKTSRGAQRWIPVGPFAFQPSEFAKLVLILVLAHYYSKAPRVGWLQRVVVPGLLMLPGLLLILKQPDLGSGLSFLAVYAAMLLMVGMRSQAMGLILLFSLMLFPFAWEMMWGSLHDYQRQRIMAFVDPDYDPAGKGYHALQSRIAIGAGELTGKGLYGGTQSQLKFLPEGHTDFVFSVFAEEWGFVGVLVLLLLFVALIWLSLEIAARAKDELGALLAVGVVCMLCFCVVVNIGMTAGMFPIVGIPLPLMSYGGSATVMTMASLGLLLNVKRRRLSLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5X2</accession>
    <name>A0A1W1I5X2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48407">
        <property type="protein sequence ID" value="SLM48407"/>
        <property type="gene ID" value="NSJP_2235"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2235"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="346" mass="38591" checksum="DBF7646B05D5EC52" modified="2017-06-07" version="1">MPRVTLHPGVLAVPDPLLGRNSFEEYLRKLLEWSSILNANWVALCISLRSHEVLAASNSYPNREDLSKSFQSFGIREYSINDIASVVTFILTKSMALEAETGIQDASWTKFQCTPPIHSAGTNDPFHDELTRLLVILSIHLRHLDRNRSNHVLAVATRPNNVSEAAVHADIDLIEFTSATTHVNTPLSLKESIIICDDHLSLVCALDECELISTAFDQESVARSIRIAWVKESISAGLKATMEDTPPFRIGNEFLTSVRDSGVLSSTGKTQKLMSTILDVLLRRNLQKSHALRRDSGGASCTVRRGTDKAIRWDIDYEHHLHVWDMQNGIPEFASVVPHHIMDIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I604</accession>
    <name>A0A1W1I604_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48299">
        <property type="protein sequence ID" value="SLM48299"/>
        <property type="gene ID" value="NSJP_2127"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2127"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="61" mass="6922" checksum="D38FFE82DED0D288" modified="2017-06-07" version="1">MASYRQELEQRSGDGIPSLDDIEPGKIVGAVIPMSERAQTQMRDSIEVIDYLLNQERVVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I622</accession>
    <name>A0A1W1I622_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transporter, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_2101</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2101"/>
    <dbReference type="EnsemblBacteria" id="SLM48273">
        <property type="protein sequence ID" value="SLM48273"/>
        <property type="gene ID" value="NSJP_2101"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2101"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="743"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="791"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="839"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="24"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="292"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="500"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="772"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="874" mass="94283" checksum="BA99C24F42BCFF6D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I698</accession>
    <name>A0A1W1I698_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4 6">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rpsL</name>
        <name evidence="7" type="ORF">NSJP_2333</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 4 6">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4 5">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2333"/>
    <dbReference type="EnsemblBacteria" id="SLM48505">
        <property type="protein sequence ID" value="SLM48505"/>
        <property type="gene ID" value="NSJP_2333"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2333"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="123" mass="13545" checksum="1FFF948EF9D37DEC" modified="2017-06-07" version="1">MPTINQLVRKGRQLAHAKTKSPALKSCPQKRGVCLRVYTSTPKKPNSALRKVARVRLTNGMEVTTYIPGVGHNLQEHSIVLVRGGRVKDLPGVRYHIVRGALDAVGVADRKQGRSKYGAKRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6C1</accession>
    <name>A0A1W1I6C1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpsM</name>
        <name evidence="8" type="ORF">NSJP_2362</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2362"/>
    <dbReference type="EnsemblBacteria" id="SLM48534">
        <property type="protein sequence ID" value="SLM48534"/>
        <property type="gene ID" value="NSJP_2362"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2362"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="131" mass="14542" checksum="263075F223B92308" modified="2017-06-07" version="1">MARIAGVDLPREKRSDIGLTYVFGIGRAAARTILDKAGIDGAVRVKDLSEDQIVKIREIIDQEYQVEGDLRKTFSMNIKRLIDTGTYRGLRHRKGLPVRGQRSKTNARTRKGRRAGVGSKPRPAARPASTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6M5</accession>
    <name>A0A1W1I6M5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ammonium transporter NrgA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nrgA</name>
        <name evidence="10" type="ORF">NSJP_2409</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48581">
        <property type="protein sequence ID" value="SLM48581"/>
        <property type="gene ID" value="NSJP_2409"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2409"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="9">
        <location>
            <begin position="8"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM48581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="388" mass="40419" checksum="0D019B95C1AAF3DD" modified="2017-06-07" version="1">MESTVHTLWLLASATLLVLTVTGIALFYGGMVRKKNVMNTMALPFAALALASIAWGLVTNLTGLGRDMESSIGQAAIGPLWSAYHGIMAAIALALVAGGIVERLRFSFFLLFGLCWIGAVYVPLAWWIWGNGWLASLGCLDFAGGAVIHISAGVSALVLALVVGPRRGYGRIDMMPNHLPLSFCGAGLMWVGWFGFTGAAVSAPMTTVTGAFVAIHLSAVTAALSWAAAEWLQRDKPTALGAVSGAVAGLVAVSPAAAYVSPASALVIGLGAGSLCYMVVNYVKLILGYDDSLDVFGMHGVAGTWGMIATGLFASTEVNAAGNDGLFFGYPYQFFVQVVAVCAAWALAGGGSWLLLKGLMWFVDPRAGDEAETMGLDLHQHGEKGYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6N4</accession>
    <name>A0A1W1I6N4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Peptidase C14 caspase catalytic subunit p20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2500"/>
    <dbReference type="EnsemblBacteria" id="SLM48672">
        <property type="protein sequence ID" value="SLM48672"/>
        <property type="gene ID" value="NSJP_2500"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2500"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025493">
        <property type="entry name" value="DUF4384"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14326">
        <property type="entry name" value="DUF4384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011963830" evidence="1">
        <location>
            <begin position="28"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4384" evidence="2">
        <location>
            <begin position="671"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="788" mass="86041" checksum="D5CF6F1C2CB2A4CD" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Q1</accession>
    <name>A0A1W1I6Q1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Riboflavin biosynthesis protein RibBA</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
                <shortName evidence="12">DHBP synthase</shortName>
                <ecNumber evidence="12">4.1.99.12</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">GTP cyclohydrolase-2</fullName>
                <ecNumber evidence="12">3.5.4.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">GTP cyclohydrolase II</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">ribBA</name>
        <name evidence="14" type="ORF">NSJP_2439</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the C-terminal section; belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="12"/>
    <dbReference type="EC" id="3.5.4.25" evidence="12"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2439"/>
    <dbReference type="EnsemblBacteria" id="SLM48611">
        <property type="protein sequence ID" value="SLM48611"/>
        <property type="gene ID" value="NSJP_2439"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2439"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01283">
        <property type="entry name" value="RibBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016299">
        <property type="entry name" value="Riboflavin_synth_RibBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="13">
        <location>
            <begin position="210"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="DHBP synthase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="12">
        <location>
            <begin position="29"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="GTP cyclohydrolase II" evidence="12">
        <location>
            <begin position="204"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for GTP cyclohydrolase activity" evidence="12">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GTP cyclohydrolase activity" evidence="12">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="254"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="298"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="12">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="12">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM48611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="403" mass="44263" checksum="81FD41262B8CDAF1" modified="2017-06-07" version="1">MSTPFNTIEDAIRDIKKGRFVILVDDEDRENEGDLVIAAEKVTPQAINFMAKHARGLICLALTPERVEELQLPQQAVENTAAFGTAFTVSIDARKDITTGISAADRATTIHVAIDPKSKPPDLARPGHIFPLKAQQGGVLKRAGQTEGSVDLARLAGLNPSGVICEIMNEDGTMARVPELAKFAKAHKLRMITIKALIEYRMQRETFVKRAASARLPTMFGDFEAIAFENQLDGATHIALVKGRIDDGQPTLVRVHSGCLTAEVLGSLRCDCRDQLHKAMEMIQKEGRGVVLYLNKQEGRGIGLLNKIKAYGLQDQGSDTVEANLKLGFKPDLRTYGVGAQILVDLGLHAIRVMTNNPRKIVGIDGYGLNVVERVPIEIQPREANVRYLRTKKKKLGHILKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6V6</accession>
    <name>A0A1W1I6V6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48747">
        <property type="protein sequence ID" value="SLM48747"/>
        <property type="gene ID" value="NSJP_2580"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2580"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMP_b-brl" evidence="1">
        <location>
            <begin position="30"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="241" mass="26037" checksum="AF6804363DE6C621" modified="2017-06-07" version="1">MSPCRLNLDEGGLLRTIVSRHSISTALCLFTIVYLAALPAKAEWYIVGQTGVILPGSLSNATVNSPTLAGGVTDARVADIDMEKASPFYGAKVGFFFPKREWFGLETEAFTSQLNIKQQTVVGGVPGRVFSETMAGSHMQLTTWAINAIVRSPSLVAELEPYGGIGPALFFSTSGDTNVSLGVNLIAGARYFVMPQLALFGEFKYNRATLRTETIQGDYSSQIFVFGISLHFDRPLPTSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Z1</accession>
    <name>A0A1W1I6Z1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2578"/>
    <dbReference type="EnsemblBacteria" id="SLM48745">
        <property type="protein sequence ID" value="SLM48745"/>
        <property type="gene ID" value="NSJP_2578"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2578"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="SSF103247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013071461" evidence="1">
        <location>
            <begin position="24"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DUF302" evidence="2">
        <location>
            <begin position="63"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="154" mass="16491" checksum="B8E06085B3A376A3" modified="2017-06-07" version="1">MKLIQALLNGALLLGIGFTPVSAGTARAESHLITKPSRYSVSDTIDRIEQAVTSKGMKVFARIDHGGEAKNVGLTMSPAQLLIFGNPKGGTALMVARPTAAIDLPMKALAWEDAEGKVWLTYNSPELLQERHAVPVEFTSKLHSVGTLLEQAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Z7</accession>
    <name>A0A1W1I6Z7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase U62</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pmbA</name>
        <name evidence="5" type="ORF">NSJP_2625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2625"/>
    <dbReference type="EnsemblBacteria" id="SLM48792">
        <property type="protein sequence ID" value="SLM48792"/>
        <property type="gene ID" value="NSJP_2625"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2625"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="30"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="4">
        <location>
            <begin position="125"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="238"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="455" mass="48370" checksum="5826F32BC2CD1863" modified="2017-06-07" version="1">MSGAITPTDGYRQLASDILAMAKRGGATEADVVIVDGENLSVQVRLAAVDRLSKAREKRLGLRVFMGKRSASTSTSDFSSNSLHQLVEQTCTLARAVVEDQVSGLPAAEEMAKEQPDLDLHDTTRLDTDQQIELARRAESAAMAADARITNSEGADFDSSSGRIVLANSHGFVGEYRSSSFSLSVSPIAVDPATGAMQRDAWYGVQRKFTKLESPEAIGAEAAKRAVRRLGAKKVGTKRVPVVFDQEMAASLMGNLCGAVSGYSLYKGASFLIGQLGKPLAPDYVTIYDDGRMVGGLGSRPFDGEGLATRKNAVVERGTLTSYLLDAYSGKKLGLPSTGNASRSVGESPSVGPTNFYLAPGSRSADDIIGTIKDGLYVTELIGFGINMVTGDYSRGASGFWIENGELAYPVEEITIAGNLKQMFRDIEMIGSDLIFRGRIASPTIKISEMTVAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I724</accession>
    <name>A0A1W1I724_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_2671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0382 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2671"/>
    <dbReference type="EnsemblBacteria" id="SLM48838">
        <property type="protein sequence ID" value="SLM48838"/>
        <property type="gene ID" value="NSJP_2671"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2671"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="PTHR43461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="135" mass="14211" checksum="E9764C4739E23D8D" modified="2017-06-07" version="1">MISGARPSPFLLFGSVAAGLAVAAGAFGSHLLKSLLDAPMLTAFETAVRYHMYHALALCMLGWAGRQKHAKYCSAAGWCFVAGIVLFSGSLYGMALTGARWLGALTPVGGTAFLVGWSLLARHAWHEIMRPSGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I757</accession>
    <name>A0A1W1I757_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48815">
        <property type="protein sequence ID" value="SLM48815"/>
        <property type="gene ID" value="NSJP_2648"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2648"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="104" mass="11243" checksum="D62559C1F73F55A7" modified="2017-06-07" version="1">MHLSHIPSAIFDRFGLSESEDFCFLNHAMRVCLLRHPTESDPPGALPATAPADGSGEYHSRPDDARSFPPRRGATIRNGIGPRRMTHGNSVSGRDGPARTDAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I778</accession>
    <name>A0A1W1I778_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Type II secretion system protein I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_2731</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP I family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2731"/>
    <dbReference type="EnsemblBacteria" id="SLM48898">
        <property type="protein sequence ID" value="SLM48898"/>
        <property type="gene ID" value="NSJP_2731"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2731"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010052">
        <property type="entry name" value="T2SS_protein-GspI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38779">
        <property type="entry name" value="PTHR38779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="136" mass="15103" checksum="87FFB70B20F2C221" modified="2017-06-07" version="1">MHDARGFTLLEVLIALAILAMALPILLGLRNFDLSLYSRAEDIAAATMLAQEKLMEAEAATAFPLGETGGDFQTPPPGAQSLIDFQHRAEKYRWKRFVMTTMLPNVREVKIQIIWPQGATEEMVEVSTYVFSSASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7A0</accession>
    <name>A0A1W1I7A0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_2719</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2719"/>
    <dbReference type="EnsemblBacteria" id="SLM48886">
        <property type="protein sequence ID" value="SLM48886"/>
        <property type="gene ID" value="NSJP_2719"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2719"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="91"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="314" mass="33873" checksum="97F357456FC433F7" modified="2017-06-07" version="1">MDADTAKPGLLKQAREFQVPPVLVPRFKEKAIELVLMLTALASVAITIGIVGVLSYESFLFFRQVSLLEFLTDSQWTPLFSEPHYGILPLVSGTVVTTTVALVVAIPAGSIVAVYLSEYASRALREAVKPALELLSAVPTVVYGYFALLFVTPALQRIWPDLPGFNMLSAGFVIGIMIVPYVSSVSEDAMRAVPLALREGAYALGATRMQTAWRVVFPSALSGIAAAYVLGVSRAIGETMVVAIAAGMQPTLTWNPLEPAATMTAYIVQVSLGDLPHGSIGYRTIFATGLTLLLMTFVFNLAGHVLRKRYRQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7C2</accession>
    <name>A0A1W1I7C2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recN</name>
        <name evidence="7" type="ORF">NSJP_2654</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RecN family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2654"/>
    <dbReference type="EnsemblBacteria" id="SLM48821">
        <property type="protein sequence ID" value="SLM48821"/>
        <property type="gene ID" value="NSJP_2654"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2654"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="6">
        <location>
            <begin position="1"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="568" mass="62141" checksum="88140BD5509EDF6E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7H6</accession>
    <name>A0A1W1I7H6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Molybdate ABC transporter, periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2831"/>
    <dbReference type="EnsemblBacteria" id="SLM48998">
        <property type="protein sequence ID" value="SLM48998"/>
        <property type="gene ID" value="NSJP_2831"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2831"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012099599" evidence="3">
        <location>
            <begin position="21"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="275" mass="30030" checksum="650C474C4A6D9723" modified="2017-06-07" version="1">MNLKHIIVLAGVLASGFATSGHTFEQFVIAASPSMRLPVEALGRQFEAAHPDVRVRLHLDSGLDLRRTIAGMENSTKGKYFIGSGPIHLVAPGGDELITRLEQKYYVLPGTRRVYAEERLVMVVPESLVDAPASFEALKTAGRLRIAVGDSEKTTLGQKTQQLLTALGVWDDVKERLDEAADTRAVIDHVLNGQADVGIVFGPDAARENQRLRVVAEAERNLVAPVLHSMAMERYCPNRALCGEFLEFIQSPQAQDTLKGLGYVSPVRVPSSHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7J7</accession>
    <name>A0A1W1I7J7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate/thiosulfate transporter subunit ATP-binding component of ABC superfamily</fullName>
            <ecNumber evidence="7">3.6.3.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cysA</name>
        <name evidence="7" type="ORF">NSJP_2820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.25" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2820"/>
    <dbReference type="EnsemblBacteria" id="SLM48987">
        <property type="protein sequence ID" value="SLM48987"/>
        <property type="gene ID" value="NSJP_2820"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2820"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102025">
        <property type="term" value="F:ABC-type thiosulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03296">
        <property type="entry name" value="ABC_CysA_sulfate_importer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005666">
        <property type="entry name" value="Sulph_transpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024765">
        <property type="entry name" value="TOBE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12857">
        <property type="entry name" value="TOBE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00968">
        <property type="entry name" value="3a0106s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="3"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="359" mass="40570" checksum="2BB81801E947B7D6" modified="2017-06-07" version="1">MSIQVDHVTKRFGTFTVLSDVSLHVQSGELVALLGPSGCGKTTLLRILAGLERPDEGRILLHGHEVTDQRITERRVGFVFQHYALFRHLSVAENVAFGLKVLPRAKRPSPDYIRNKVEELLSLVQLRAMADRYPSQLSGGQRQRVALARALAVEPKLLLLDEPFGALDAKVRKELRRWLRRLHDELHITSILVTHDQEEALESADRIVVLNQGHIEQIGTPDEVYEQPATPFVYRFLGDVNVFHGRAPHERVAHDSLEGHHLSSWTEAGGDHEVAFVRPHDLELSLERTTNAQLETTVRLVINAGARVLLELSTTDSGQHIEVELTKDRYRELKLQQGDVVFIHPRQLQVFRVPDPLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7J9</accession>
    <name>A0A1W1I7J9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48839">
        <property type="protein sequence ID" value="SLM48839"/>
        <property type="gene ID" value="NSJP_2672"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2672"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="327" mass="34778" checksum="C61076D1D4033F97" modified="2017-06-07" version="1">MDLSCDIVKKSDPAAGTLARALTILACSVLYLFGAIGTAGADSTASRPAGFPDWPLNLTTHGNKLAAVDSDQAAKEIFATTIGPAVNLSEVAATIGAKALPAKMSKDLLLGEITQSAQRLVAALAAWQLADSVSTSLQQAGESISALPDPASRRIEWLKANGPFPSLAKIQPAVPGPGQDSSPAAEPPLDHTKLALAAGQTAMEASQQAWSEWWRLKSWKERVRALRGQTRLCGTWQWVIHNHQQHHQEQKLSLMFPPAGKDGSGLAGLAETIVLGDTVYLRWEIDGRVQEDSLLFSKESQRLEGSFVNNQGGWGSITGKRTAGCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7K5</accession>
    <name>A0A1W1I7K5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetoacetate metabolism regulatory protein AtoC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atoC</name>
        <name evidence="9" type="ORF">NSJP_2807</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2807"/>
    <dbReference type="EnsemblBacteria" id="SLM48974">
        <property type="protein sequence ID" value="SLM48974"/>
        <property type="gene ID" value="NSJP_2807"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2807"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="144"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="450" mass="49927" checksum="5EC929B640CD78D7" modified="2017-06-07" version="1">MTIVHALIVDDEEYVRLVLEQALRQEGCEVTAAKNGKHGIELLQSTTFDFVITDLRMPGTDGKAVLKWVREHQPEVDVVMLTGHGDVKDAVEAMKQGAWDFLIKDTPFDAAIVKSALSKLRTIRALRKENVAARHGGFTRDVIVEGTSPAWRQLRSQITKVAPSSAPVLVQGETGSGKEVVARLLHDLSARSSGPFLSVNCGAVSRELLESELFGHERGAFTGATSAKLGLVEAAEGGTLFLDEIGEMPGPMQVSLLRFLDQGEYRPVGSTRTLHADVRLVGATNQDVRTLVDQGRFREDLLYRINTVTLHVPPLRERREDIVLLAEHLLRNVRTPGSSNRRLSTEGLDCLASYQWPGNIRELRNVIERLVMLGTDRDVFTDDEIRQVLPKHHGSIQAEDLSRISLEEIERRHITLVLDACDGNKTQAAKILGIDYKTLLSKLKKYESTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Q4</accession>
    <name>A0A1W1I7Q4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49078">
        <property type="protein sequence ID" value="SLM49078"/>
        <property type="gene ID" value="NSJP_2911"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2911"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013252501" evidence="1">
        <location>
            <begin position="30"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="338" mass="37924" checksum="204AC9225A6ABDE7" modified="2017-06-07" version="1">MSSRIMARLAGAGWVTAVLFVAQTGAASAETNFEGRALLFYTDDVGIFSATRRLTRDEDPTQPALDSILTNQGSDVVFEPDAIARTSVDNRWGTTHLSIRGQGFIYAENPRYNHGTLKVQALQAFTPDTHLLLRYYYAPNLFLGENEDRRPGGEGLVNEVVTSQIASARIEQRLTKDVEVRLLGRVGIRRYNDAFAQRDTNFWTIGPHVEWRVSERVKLGLSYHYERGLAEGRNEPQLRDDVSYVNNYVSADVDVELMERLSLSAAFHYERNDWTSGIVGDIRNGAHEDVIQGEVMLIQQLTESIRAMAGFQRSNRKQSFEPDAIKNTNVAFGVAAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Z8</accession>
    <name>A0A1W1I7Z8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4136 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2766"/>
    <dbReference type="EnsemblBacteria" id="SLM48933">
        <property type="protein sequence ID" value="SLM48933"/>
        <property type="gene ID" value="NSJP_2766"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2766"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025411">
        <property type="entry name" value="DUF4136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13590">
        <property type="entry name" value="DUF4136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4136" evidence="2">
        <location>
            <begin position="70"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="223" mass="24800" checksum="133267508339F4B8" modified="2017-06-07" version="1">MASAARYIRMFEYGMILLRHHPSEMNHGNHSTLKRHERSSRGNRLVLRITAVCVGLLAALVSACASPKVGYDYDRGADFTAYRTYEWMPDSRSPAGDKRIDNDLVDARIRAAVDGQLRQKGYTNPAAGRPDFYVSYQAAVTDMMKGASTQRYIGDRASGLYTTVSDVHPYKDGALLVDIVDGATQKLVWQGTASAEIDPALTARERDERIARVVKAMFDHFPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8N6</accession>
    <name>A0A1W1I8N6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49229">
        <property type="protein sequence ID" value="SLM49229"/>
        <property type="gene ID" value="NSJP_3062"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3062"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="2">
        <location>
            <begin position="33"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="103" mass="10857" checksum="1B8A14B01FFB1998" modified="2017-06-07" version="1">MKNAGPVGPTVQGNTPGASTTRHPGQIPVGYVTIHGAAQYASVSAKTVTRWIRSGLPVHQGTTRGKVLIRPGDIDAYLTRRQAPVVNLHALVDDVLQGLKRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8R2</accession>
    <name>A0A1W1I8R2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49311">
        <property type="protein sequence ID" value="SLM49311"/>
        <property type="gene ID" value="NSJP_3144"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3144"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="196" mass="22897" checksum="6FD791CDC22E7AD8" modified="2017-06-07" version="1">MRGDAITDLSDTQYKLAEAEFFLAQLKRNHGKFNKFNFYLSAFISAARSVYWIMVREYKDVPGWNEWNREKGRTASAEVQDLLRRTTKMRNYTQKVGPIMAEIVTKIGLPKMEITRLNKLGPGRIMLQGTMQNCRVIHLNSAGEMVIFQMVTLKKFGRVEPKFFPHKDTLEECNKYYNLLAEIVKECTDRFKIPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8V4</accession>
    <name>A0A1W1I8V4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49434">
        <property type="protein sequence ID" value="SLM49434"/>
        <property type="gene ID" value="NSJP_3267"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3267"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="73" mass="8367" checksum="6E03B4899FFF5A74" modified="2017-06-07" version="1">MDRLKPVIETLFRAKQQRRKKLVALPFPEKVRAVIRMQQMAAPILLARGKSVRVWELGLVQDGRLSSGARQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8W1</accession>
    <name>A0A1W1I8W1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49444">
        <property type="protein sequence ID" value="SLM49444"/>
        <property type="gene ID" value="NSJP_3277"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3277"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013275122" evidence="1">
        <location>
            <begin position="34"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="135" mass="15161" checksum="A0C15A36FDD6590A" modified="2017-06-07" version="1">MSVQHRRLNRYISLCWSLAVLLIVGCASPPAPSTPKPIAQRLVGKSQTHIRQCAGQPAKEVPYETGVILRYYKEASTFVGSTTFLEGSQHMRHRGCWASLLIEQDQVTGVEFEPIPKETNQIDDLCDEMFRTCVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I952</accession>
    <name>A0A1W1I952_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49409">
        <property type="protein sequence ID" value="SLM49409"/>
        <property type="gene ID" value="NSJP_3242"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3242"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="80" mass="9196" checksum="D39D0AE8DED1084C" modified="2017-06-07" version="1">MNIQRSVSRFVAQSNDIFHQLRSKGEILSDVDLVTLREQLYILDTEADHLQNLKQPRSEMSRLIPAGRLPKVRTGRHGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9F6</accession>
    <name>A0A1W1I9F6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stress protein, member of the CspA-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cspC</name>
        <name evidence="4" type="ORF">NSJP_3511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3511"/>
    <dbReference type="EnsemblBacteria" id="SLM49678">
        <property type="protein sequence ID" value="SLM49678"/>
        <property type="gene ID" value="NSJP_3511"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3511"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="71" mass="7750" checksum="C1384F1A102006E0" modified="2017-06-07" version="1">MKTKGTVKWFNDRKGFGFIRLDSGEDVFVHYSALQGEGFKTLKEGENVEFDIVQGAKGPQAANVAKQAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9N6</accession>
    <name>A0A1W1I9N6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">Elongation factor Ts</fullName>
            <shortName evidence="5">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">tsf</name>
        <name evidence="9" type="ORF">NSJP_3591</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3591"/>
    <dbReference type="EnsemblBacteria" id="SLM49758">
        <property type="protein sequence ID" value="SLM49758"/>
        <property type="gene ID" value="NSJP_3591"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3591"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="8">
        <location>
            <begin position="56"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="5">
        <location>
            <begin position="81"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="198" mass="22054" checksum="4F296A7B5EAA9A78" modified="2017-06-07" version="1">MAGSSQLVKELREKTGAGILDCQKALQENGDDIEKAVDYLRQKGLAAAQKKAGRETNQGLIHAYIHMGGKIGVLIEVNCETDFVARNEEFKAFVNDLALQIAAAKPQYVRREDVPTATVDKERTIYEGQAKEMGKPPAAWPKIVEGKLEKFFQESCLIEQAFIKDPAVTVKDLLSQKIAKIGENMNIRRFTRFQLGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9N8</accession>
    <name>A0A1W1I9N8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3346"/>
    <dbReference type="EnsemblBacteria" id="SLM49513">
        <property type="protein sequence ID" value="SLM49513"/>
        <property type="gene ID" value="NSJP_3346"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3346"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012529061" evidence="1">
        <location>
            <begin position="22"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="246" mass="26361" checksum="CCBC99CDBE8BFB95" modified="2017-06-07" version="1">MAMRVLAYLFVLLIIPGAVQAGGGAGPDIPTLTVNGNGVVTVQPDTAFVTVGMETAAKSLSEAQRLNSMTMQKVMDRLQQQLKIEKERIQTSSFNVMPQYRPPSKHPVDAPAAAPEIVGYTVSNRITVEIRDLQKVAAVIEETSAAGANHFQGLQWGLRDEQQARLQALKLAAGKAREKAATLSEALSLKLARLMNVTEGVQFIRPAPYAGRAMMAADSGGGDIPLLSGEMRVEATVTLSYEISKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Q3</accession>
    <name>A0A1W1I9Q3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3553"/>
    <dbReference type="EnsemblBacteria" id="SLM49720">
        <property type="protein sequence ID" value="SLM49720"/>
        <property type="gene ID" value="NSJP_3553"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3553"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="260" mass="28826" checksum="F2A9664D0DBDAB1A" modified="2017-06-07" version="1">MMIGIDRRKIALLHLLLVPGDIERNRSVTVEAVKLAAKTGAQWIVTPELTVCGLQFPQVVGTEWIQPQPDPWMQRFCQLVKTLRCTVFLAIPEREGRKLYNSVFVIDPDGRIIGRHRKINVKSDSLSWSMPGDRVAAVECDGVKVGLPICSDVYTRHLTDALKTDGAQMIISPASWGPGIHGPNGEWEARTEETGLPLIVCNRTGTERTLDFLKAPSLAVKNGKRILSYTSDRSAVLTCEWDFVAMKPLSAAYQTVYLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9T1</accession>
    <name>A0A1W1I9T1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49807">
        <property type="protein sequence ID" value="SLM49807"/>
        <property type="gene ID" value="NSJP_3640"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3640"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="141" mass="15199" checksum="E6BFE3C626ED8D00" modified="2017-06-07" version="1">MTEAASHGKVISLEYTVKLEDGQLVDTNVGQDPLTYTQGANQIIRGVEAAVEGMEIGQTKQAIVPPTEGYGDRDPNAVHEVPKEKVPQEAKVGTMLHGKDSSGRKIQPTVSAIKDDTVILDFNHPLAGKTLHFDLKVLNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9X8</accession>
    <name>A0A1W1I9X8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49792">
        <property type="protein sequence ID" value="SLM49792"/>
        <property type="gene ID" value="NSJP_3625"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3625"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="317" mass="35200" checksum="AB58DCCC66E83A46" modified="2017-06-07" version="1">MVRSRLYGVDSIRMAQSYHFLQQIVGADSVDRSDSLKGSYLMREADMHEESRKQSDRDQSLSRRGLLIRAGLMSVGALQGSGLVNGLTSDGLAEEHQDWVYRVQRSQDSPSMGELMNILRTQPGGADALEKARRGGANIPGENPSYPKLGKSPDPVPSPNFSVKFSLGHLKEGENLMRFQQVSILENGTVRLLKSMDNGNFTPSGFGASGTPEVFIQFRPPADGWYLFNLRGVIDAYWQVSAALRWSYSLSGAEPIQTWTYGKSRQPGIRSFPAVFWYSPTSAPTSPPRLQFSLSETYLDFVDAMVAWIPYVSQSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Y1</accession>
    <name>A0A1W1I9Y1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator, NifA subfamily, Fis Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3628"/>
    <dbReference type="EnsemblBacteria" id="SLM49795">
        <property type="protein sequence ID" value="SLM49795"/>
        <property type="gene ID" value="NSJP_3628"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3628"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="193"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="501" mass="55469" checksum="EC7DE0C240235E24" modified="2017-06-07" version="1">MDPSFRPSREQLSALLAISRLLTSSVDLPSLLKLIVTSVTELLECEASSLFLIDATGEQLILSVVTGPVGGEIKELRIDVGEGIAGWVAKNRKSLIVNDAKHDPRFSPAVDKATGFQTRSILAVPLMDHGQIVGVLEILNTAKAKQFDQSDVDLLSAFGSYASVALRNAGLLATMREESQILKGSADERYRTLIVESPRMHEVVDTLRRAARSNSTVLLLGESGVGKEILARSVHNWSPRASKPFVAVNCVALSDQLLESELFGHEKGAFTGAHQQKKGLLEVAQGGTIFLDEIGDMKPNLQAKWLRVLQDREFDRVGGTQPIRVDVRVIAATNQDLKEAIKDGRFRKDLFFRLNVVTVTTPPLRERRDDIPALARFFVGRYAKDMKRPHVSIDPKAIEALRQYDWPGNVRELANVIERAVVLASRDVISVDDLTLEAMEPNARPTEELMDLPFHKSVEHFKRMRLQTAIAKTRGSKTKAAQALQLQPTYLSRLCKQMGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA28</accession>
    <name>A0A1W1IA28_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="7">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">tilS</name>
        <name evidence="9" type="ORF">NSJP_3572</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3572"/>
    <dbReference type="EnsemblBacteria" id="SLM49739">
        <property type="protein sequence ID" value="SLM49739"/>
        <property type="gene ID" value="NSJP_3572"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3572"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012796">
        <property type="entry name" value="Lysidine-tRNA-synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11734">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00977">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02433">
        <property type="entry name" value="lysidine_TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TilS_C" evidence="8">
        <location>
            <begin position="398"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="38"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="483" mass="54258" checksum="6502D88FB639C0FE" modified="2017-06-07" version="1">MAVRSVRPARTAFLKHVILAIRRQRLFSPGQHLLIAVSGGPDSTALASVLTRLAPKWRLRLTAVHVNYRLRGAESDEDEASVISFCKGRKLPLRVLRLAVAKRSGQSSLQALAREARYDAMKRLAEEIEADRIAVGHTADDQAETMLLWMLRGAGLTGLAGMPFVRDSTVIRPLLAVTRKQVLSYLKQEKLSYREDSSNATERYKRNRIRHELMPILSSLSPKIVTHLQQSAELLREDERYLDQVTREHLSALVTSPDNGGVRMDGRAFALLHPALQRRVLRMVLRNLDDIRRAPGARVVEAARRFVLSGRRPVCVPHRNVRLMRQGHWFSIARGTHSAPGMLQAIEVPVAVPSVVAWAGTNTQFHVQLLSRQEAEPFLRAEMANRAVFDADLVGTPLVLRGWRPGDRFKPAGMKGKSKKLQDLFTDVKLPRDKRTVHPVLAAPDGIVWIPGIRRDERFLVRDRSTRCLLVTMIGGGNEKGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA58</accession>
    <name>A0A1W1IA58_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49886">
        <property type="protein sequence ID" value="SLM49886"/>
        <property type="gene ID" value="NSJP_3719"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3719"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="61" mass="6861" checksum="154F7875EBDF82C5" modified="2017-06-07" version="1">MRFVKVKDEERAGEVAINLDLVREAHFGGGLLHIYFERSSSSQDDMTFTGENAQKIWAAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAB5</accession>
    <name>A0A1W1IAB5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3768</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3768"/>
    <dbReference type="EnsemblBacteria" id="SLM49935">
        <property type="protein sequence ID" value="SLM49935"/>
        <property type="gene ID" value="NSJP_3768"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3768"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1355"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1315"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1809" mass="196742" checksum="E00994C68CB82D0F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAI4</accession>
    <name>A0A1W1IAI4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50016">
        <property type="protein sequence ID" value="SLM50016"/>
        <property type="gene ID" value="NSJP_3849"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3849"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024952">
        <property type="entry name" value="Lipo_LPP20-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02169">
        <property type="entry name" value="LPP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="312" mass="34877" checksum="CECE00CBF6939D8A" modified="2017-06-07" version="1">MIDRMPVLVICAAALLLVGCFGGKAKPAWVNGMSPDYSADQYLTGVGQSDRSAVAEDQAYAALARVFKTEVSAQAKDWESYLVVEQRGQSRDERRLTIDNLTKVSTDKVLENVRIADRWFDSKKQVHYALAVMQRSQAETAFMEKITELDRGIQADVDDAHRSADKLAKVRGLRRAAHNLVIRETYNADLRVVRPSGQGMASPYRVNELTMELEQFLATNLLFAIDVTGDQTQAAQRALSEGLIREGLQIVDRPATESVSSSASGGHAPELLLRGFVRVWPIDVRDPQFMYVRWCGDFEVVEIKGQRPRRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAN7</accession>
    <name>A0A1W1IAN7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3814"/>
    <dbReference type="EnsemblBacteria" id="SLM49981">
        <property type="protein sequence ID" value="SLM49981"/>
        <property type="gene ID" value="NSJP_3814"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3814"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013630">
        <property type="entry name" value="Methyltransf_Zn-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038576">
        <property type="entry name" value="Methyltransf_Zn-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013691">
        <property type="entry name" value="MeTrfase_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08421">
        <property type="entry name" value="Methyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08484">
        <property type="entry name" value="Methyltransf_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_13" evidence="1">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_14" evidence="2">
        <location>
            <begin position="267"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="432" mass="49319" checksum="D6C8C4D01E206D50" modified="2017-06-07" version="1">MINAPEIVLEEEKHMNEQDESVDSALCRGCGERSLHTFIDLGLFPLCQTYIERHQLDNMEPFYPLHAYVCNRCFLVQLPEYVAPQNIFTEYAYFSSHSDSWLQHVRASADALTKRFNLGSTSQVIEAASNDGYFLQYFMEKGIPVIGVEPAVNVAQVAIGKGIPTVSKFFCVETARRLRDEGKQADLMLAVNVLDHVPDINDFVSGLKLLLKPNGVVVVEFPHLCKLIEGNQFDTIYHDRFSYLSFTAVEEIFLRQGLFPFDVEELPTHGGSLRIYACHRSAGVKPPTEQVARLRAKEEAWGVKTMDYYASFRKQVEDTKRNLLECLVRLKRERQTIVGYGVPAKGNVLLNYCGIRTDFLDYLVDRSPYKQGKHTPGTRIPIHSPETIRDSRPNYVLILPWNIKEEIMDQLAYIREWGGKFVVPVPTVQVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAN8</accession>
    <name>A0A1W1IAN8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3666"/>
    <dbReference type="EnsemblBacteria" id="SLM49833">
        <property type="protein sequence ID" value="SLM49833"/>
        <property type="gene ID" value="NSJP_3666"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3666"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="126" mass="14027" checksum="DCE5D7A719B59C08" modified="2017-06-07" version="1">MKNKVVMFEIPASDFKKAKEFYEAVFDWKVELCGDEGAMALTTAADKEYNPTELGGINGGFYRRKSKSDQPSCGVETESIDETLEAIKKAGGKVVTPKHPIEEWGFMADFADPDGNVLALWEKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAP2</accession>
    <name>A0A1W1IAP2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3802"/>
    <dbReference type="EnsemblBacteria" id="SLM49969">
        <property type="protein sequence ID" value="SLM49969"/>
        <property type="gene ID" value="NSJP_3802"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3802"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="27"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="195"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="376" mass="41333" checksum="4047C238C355EA2F" modified="2017-06-07" version="1">MMMEFGDPQLRPHSCRLLYLVGQLGRGGLERQLCYLLRILDRKRYRPAVMLWNPSPNDIYLSDLAALEVPIHPVPTGAGASAKLSYCRSLVRRLSPEVIHSYSFYTNFAAYYAAVGTQAICLGSIRSNFLFEQNKAGPWLGRLSSLFPRHHISNNLQAAETIWRSTGIFRPGTLSVVRNGVDLDLFSKVPPPLGGVPLILSVGSLLPIKRWDRLLTMVRELKRRKLRFMVQVAGEGPLRKMLEGQAQELHVADCLEFLGAVRDIPTLLAKANFLVHTSDAEGCPNVVMEAMAAGRAVVATDAGDVRHLIENGASGFVVSPGDDAALADRAAALLTDQLLCQSMGENARARAERDFSVHGLVSRTLDAYKAAGWKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAR8</accession>
    <name>A0A1W1IAR8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_3937</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50104">
        <property type="protein sequence ID" value="SLM50104"/>
        <property type="gene ID" value="NSJP_3937"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3937"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="41"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="138"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="255"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM50104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="359" mass="40256" checksum="9AC491EF3951F87D" modified="2017-06-07" version="1">MMLLPLLPLFMLLSCAPGPPNAPSKESLQIEASLRSRQHALVNEQVHRLALISLAIQDPIRVPRYVPVSLVISNEINAYCDGEQIGVLQGMMRFLADDNELAAVIGHELGHCTRSHVDRRRAREAERFSSVSPLWGTKQFDREEEREADLDALLFLYYAGFDIQAAVTMWERKAAALPYTNQKSYFSTHPGSLERIAQTEKTVETLKAGIDPLTNRPLHRAPDPSVSLPAWFDRTLVFSRSKLLRWIAEGQEPFLAAQRAAMDRERARLNSAEKLADPFASATIASEAKEALKAVQDRLADRERLMERASMNAIRRNILRLTAEQIPHDPNGRLIALLDEMLATMETVSGDAVPSTFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAU3</accession>
    <name>A0A1W1IAU3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3967"/>
    <dbReference type="EnsemblBacteria" id="SLM50134">
        <property type="protein sequence ID" value="SLM50134"/>
        <property type="gene ID" value="NSJP_3967"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3967"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PTHR11060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="413" mass="46409" checksum="886516CA4DF576A3" modified="2017-06-07" version="1">MMPGTSKDPAQYPVLRNLQFSPIKEGDDQFVVLWDPSGLSKEKLVLPLNYFFIVQHFDGDHSLQEIGGLYLKRFGEFLLPAKVDQLVADLDAKLFLEGGRTEQAKQQAHESYRQAPMRRAQFAGRSYEADGEKLQKQIDGFFTSKEGPDFKPSANSGKPIRGLVAPTYELKQAGPIYAWAYKELQEAQQPSVYVIVGTAHAGLESLFAVTDKDFETPLGIVSADRQIVDLLRSRAPEYFQEEIAHQTEHAIEYQLPFLQYAVTGGMGATIVPILSSFSADSLRDASVRDRVERFISSLRDILAASGKTYSLIAAGELAHLGMRYGDSAPPTDFSFHRCMQSDLEMLKFVEEMKPDEFAGYIQKENDRRRISGFSPIYTLLRLIQAEQGQVLRYDRGITDQYNSTATFASMSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAV1</accession>
    <name>A0A1W1IAV1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General secretion pathway protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gspG</name>
        <name evidence="2" type="ORF">NSJP_4010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4010"/>
    <dbReference type="EnsemblBacteria" id="SLM50177">
        <property type="protein sequence ID" value="SLM50177"/>
        <property type="gene ID" value="NSJP_4010"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4010"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="168" mass="18921" checksum="927024448C6C440E" modified="2017-06-07" version="1">MKQSGVTLLELMVTLTIVMILASVALPLSRLSTKRAHEVELRQHLRIVRAAIDTFKLEWNRDGDVLVGPVCLKNKLTCKEVSSLYGYPKSLNVLLGVTLTGEEATVRGSTIRRYLRSLPIDPLTGKADWRFRCYKDAPDASSWCGEDIYDVMTKSDDVALDGTKYRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAV2</accession>
    <name>A0A1W1IAV2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trxA</name>
        <name evidence="4" type="ORF">NSJP_3736</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3736"/>
    <dbReference type="EnsemblBacteria" id="SLM49903">
        <property type="protein sequence ID" value="SLM49903"/>
        <property type="gene ID" value="NSJP_3736"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3736"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="115" mass="12663" checksum="DC9F3FE7922B87D4" modified="2017-06-07" version="1">MITDVTDRTFDRLVEEATVPVLVEFWKPGCGSCRALLRQLVGVQEETAGKLLVVKMNVEENHQIPAELEISSLPVLALYRRGRFDRFIGGIGTREALLAQLTTLLDAHGAGDLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAW5</accession>
    <name>A0A1W1IAW5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3973"/>
    <dbReference type="EnsemblBacteria" id="SLM50140">
        <property type="protein sequence ID" value="SLM50140"/>
        <property type="gene ID" value="NSJP_3973"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3973"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006230">
        <property type="entry name" value="MutL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13941">
        <property type="entry name" value="MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="614" mass="66136" checksum="901619A2B379CA53" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB06</accession>
    <name>A0A1W1IB06_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ALGX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_4051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; alginate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4051"/>
    <dbReference type="EnsemblBacteria" id="SLM50218">
        <property type="protein sequence ID" value="SLM50218"/>
        <property type="gene ID" value="NSJP_4051"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4051"/>
    <dbReference type="UniPathway" id="UPA00286"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031811">
        <property type="entry name" value="ALGX/ALGJ_SGNH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16822">
        <property type="entry name" value="ALGX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0016">Alginate biosynthesis</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="ALGX" evidence="5">
        <location>
            <begin position="371"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM50218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="501" mass="56202" checksum="EBB73E8217FC8992" modified="2017-06-07" version="1">MPKKQVFPLLTIGCAVGLLWSYGLFVSILDETIVGVSVGLRDVVVIAAVGVCLILALGQWTLKSQVLSSREAYAIGGGAIAILGAMLALDTAYSGYLSSQQPLRWDREISRVSDRNSWVGELYPDLFYPDHENYRLHKPSRVVEGFHFGDMYTPSMLKSKTLMESVLSRKYVKIAINEDGFRGGKAFDNARNARIVALGDSFTFGWGVNEEATWVGHLERSLGETIYNLGIHDSSPRQEYLLLEHLLDQGKLRLDHGLLLWLIFEGNDLEDSYDTVRPTSESTMTQVLDNTLLSGLWKIPRVIKHQSVVDIFRSGRATFLMSGAGRSGGAYWVDGIQLATPLYRSPRFGYKLFSPLQIERAKSTREYVASHPNRSALHRTIQDMAALSKKHGFEVVMLLAPSDARLYGSYFDDFPQASDRAHFLEAVSEEAGAVSFRVVNLSEALRSYAENELLYFRDDDHWNERGHEVVAEIVGKRLNVQRQSASRSNTVVQSLWKQRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB07</accession>
    <name>A0A1W1IB07_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50079">
        <property type="protein sequence ID" value="SLM50079"/>
        <property type="gene ID" value="NSJP_3912"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3912"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005625">
        <property type="entry name" value="PepSY-ass_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34219">
        <property type="entry name" value="PTHR34219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03929">
        <property type="entry name" value="PepSY_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="379" mass="42564" checksum="0CD972F3B6BC2723" modified="2017-06-07" version="1">MTIDSFRRWYWIHKWTSLVCTVFLLLLCLTGLPLVFSDELRLWLGEAVEPPEHAVRAEPVILDALIQDARARRPQDHVKFLIRDDDGPAWFVTMGDTPAAQENSATFTYDSRTGEFLHAVPQNEGIVNVLFRLHVDMLAGLPGTLFLGVMGLLFVASVVSGVVVYGPFMRKLPFGLVRGARGPRLRWLDLHNLLGIVTVLWALVVGITGVVNTLDRPLLGYWQMTEISEMIAPWKGKNPPARISPVDDAVRAAEGAVPDMLIRFIAFPGTPFAGSHHYMVFMRGDTPLTARLLAPLLVDAETGQVSDRRDLPWYLTLLLVSQPLHFGDYGGMPLKILWALLDAITIVVLWSGLYLWWRKRQQRVEDMIVVDPSQNAVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB63</accession>
    <name>A0A1W1IB63_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50139">
        <property type="protein sequence ID" value="SLM50139"/>
        <property type="gene ID" value="NSJP_3972"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3972"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="375" mass="39795" checksum="6A863F3CEBE54766" modified="2017-06-07" version="1">MAHSYTPGLTVTDRTVIRRRRLLPLAGEVLVHAGGNVRCDQAVARAQLPGKVYPVNLANQLSVAPGEIKEYLVKREGEAVQKDEILAENKPLIKWFKTEIRSPVAGTIESVSSITGQVLLREPPRILDLLAYVDGAIAEVIPHQGVVVEADCALVQGIFGIGGETWGEIIVAVGSPDEPLLPAHLTAAVKGKIVVGGSFLSSGTMAKAKEIGVAGLVVGGIHDKDLRELLGYDLGVAITGTEQVGFTLILTEGFGAIPMAAKTFNLLSAHVGQRAAISGATQIRAGVIRPEIVVPYRGPAVTAAGRGHQREGVRLGDSVRIIRDPFFGRISEVSALPHDLRKIPTESEVRVLEVKFSDGTRAVVPRSNIEVIEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB69</accession>
    <name>A0A1W1IB69_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3846"/>
    <dbReference type="EnsemblBacteria" id="SLM50013">
        <property type="protein sequence ID" value="SLM50013"/>
        <property type="gene ID" value="NSJP_3846"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3846"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="147" mass="16885" checksum="716BC724185D4813" modified="2017-06-07" version="1">MPYYYFDSTALVKRYSMERGTRIVNKLMVKRGKVAILPTWSVTELYSSFSNRAQQGEITRDDCYSVIHKFERESMEGLFQFIVPTTQTYLATKELVMEYPFLRAQQVMHLALALELKPLRLTVVSADVQLLAASKTAGLHVINPEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBB2</accession>
    <name>A0A1W1IBB2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="1">MECDP-synthase</shortName>
            <shortName evidence="1">MECPP-synthase</shortName>
            <shortName evidence="1">MECPS</shortName>
            <ecNumber evidence="1 2">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">ispF</name>
        <name evidence="4" type="ORF">NSJP_4113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the IspF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="1 2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4113"/>
    <dbReference type="EnsemblBacteria" id="SLM50280">
        <property type="protein sequence ID" value="SLM50280"/>
        <property type="gene ID" value="NSJP_4113"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4113"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="1 2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="3">
        <location>
            <begin position="8"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="1">
        <location>
            <begin position="40"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="1">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="163" mass="17183" checksum="7C3E2CE01BE1BBD3" modified="2017-06-07" version="1">MSKQSGWRVGYGYDVHPLGAGRKLILGGIEIPHNKGLLGHSDSDVLVHAVCDALLGAMGEGDLGRHYPSSDPKYKGISSLKLLEDVIAKLTSKGYRIGNIDTVIVAQAPRLGPHLPAMQKKLAEVSGIAQDLVNVKVKSGEGLDAVGKEEGMTAHAVCLIEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBB7</accession>
    <name>A0A1W1IBB7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_4161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4161"/>
    <dbReference type="EnsemblBacteria" id="SLM50328">
        <property type="protein sequence ID" value="SLM50328"/>
        <property type="gene ID" value="NSJP_4161"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4161"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="77"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="278"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="475" mass="52356" checksum="2A12174DAEE5F51A" modified="2017-06-07" version="1">MGTYAAWVAAQAGAPPVPLVKRPWLHGFARRWHYDSIEPSVPAGMAAFLRRVRPNHSSPSDPGKLRVLHCIGGLIPGGAERQLCNFVVGAHRRGLELRVLTLRESVDDDAHYADLLQRAGIPPFVAGANFNTDFVRKLRARPGTLELLNRLPVFFLPYTVDILGELLIDPPDLVHAWLDHNNIWAGLAALLAGVPHIVLSTRNVNPNHFPYLAHPLFKPWYQLLASFPHVQFINNSHPGAEDYAAWLDLKPECFRVVHNGVDFDTVVHPKPDAVQAFRDEIRLPSDAPLVAGVFRLSEEKQPMVFFEVVRRAMSRVRNLHAVVAGVGPCEGQLREAIAQYGLADRFRLLGRRKDVEVVMAAATAVLLTSRQEGTPNVLLEAQWLGCPVVSTKAGGAADAVSHGRTGLLFEVGDLDGLTEALLSLVLDRNGRERLSQAAPGFIAERFGLDRMVEETLAVYRQALHPYSTADVKGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBE9</accession>
    <name>A0A1W1IBE9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative tonB-dependent receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NSJP_3926</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50093">
        <property type="protein sequence ID" value="SLM50093"/>
        <property type="gene ID" value="NSJP_3926"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3926"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030149">
        <property type="entry name" value="FcuA/FatA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF82">
        <property type="entry name" value="PTHR32552:SF82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07660">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0798">TonB box</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="STN" evidence="9">
        <location>
            <begin position="84"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM50093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="874" mass="93908" checksum="C140AD67C208ECB8" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBL5</accession>
    <name>A0A1W1IBL5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Serine acetyltransferase</fullName>
            <ecNumber evidence="4 9">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysE</name>
        <name evidence="11" type="ORF">NSJP_4112</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="4 9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4112"/>
    <dbReference type="EnsemblBacteria" id="SLM50279">
        <property type="protein sequence ID" value="SLM50279"/>
        <property type="gene ID" value="NSJP_4112"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4112"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010493">
        <property type="entry name" value="Ser_AcTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005881">
        <property type="entry name" value="Ser_O-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06426">
        <property type="entry name" value="SATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000441">
        <property type="entry name" value="CysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01172">
        <property type="entry name" value="cysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SATase_N" evidence="10">
        <location>
            <begin position="3"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM50279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="217" mass="23451" checksum="3F3EB32C29D7CC38" modified="2017-06-07" version="1">MFKAIRQDLQAVFDRDPAATGRMEVVVTYAGFHALVAYRVAHWLKVRNVPFIPRLISQIARWATGIEIHPSAKIGTGFFIDHGMGVVIGETAEIGDHVTLFQGVTLGGTGKERGKRHPTLGNHVLVGAGAKILGGITIGDNVKIGANSVVLKSVSPNSTVVGVPARVIKSQGDRLPDATMDQTNLPDPISDRFLALEQEIIQLRKKLENRDVVPPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZW4</accession>
    <name>A0A1W1HZW4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">tgt</name>
        <name evidence="6" type="ORF">NSJP_0124</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0124"/>
    <dbReference type="EnsemblBacteria" id="SLM46296">
        <property type="protein sequence ID" value="SLM46296"/>
        <property type="gene ID" value="NSJP_0124"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0124"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="5">
        <location>
            <begin position="14"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="4">
        <location>
            <begin position="245"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="381" mass="42401" checksum="5EBA65B803D350C5" modified="2017-06-07" version="1">MEFTVKQTAGERHARLGVLTTAHGQIETPAFMPVGTLGPVKGIDPEELHQLGFRLFLNNAYHLYLRPGHKVISELGGLHRFAGWSGSILTDSGGFQIFSLAGLCRITDEGVTFRSHLDGSTHVITPESAIGIQEDLGADIIMAFDQCVALPADRDRVADAVRRTTLWAGRCQESRRRTDQALFGIVQGGLDPELRRKSARDIVALGFDGYAIGGLSVGETKEEMYRMLEICAPELPSVKPRYLMGVGMPENLIEGVARGVDLFDCVIPSRHGRTGWLFTESGRVSIKQARYTRDERPIDPNCACPVCRRYSRAYLHHLYNVKEMLASRLNTTHNLWYFSDFMRRLRGAIADGTFANFRDAFYRMRAEAPSEFVGTAETSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZY6</accession>
    <name>A0A1W1HZY6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">fn3_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0148"/>
    <dbReference type="EnsemblBacteria" id="SLM46320">
        <property type="protein sequence ID" value="SLM46320"/>
        <property type="gene ID" value="NSJP_0148"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0148"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="fn3_3" evidence="1">
        <location>
            <begin position="229"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="320" mass="35605" checksum="E00AA98EBB1FDA6E" modified="2017-06-07" version="1">MAELYLVFEGLIFVEGEMKRVVIIALWSWLAVGASLGWAYEEAQVVDGGTVTGKVKMTSGKPTPKGFNLITFPDPVYCGRISTGTGWRILKEFEVAADGGLKDVVVLLSDVPKGKPFKFEPQTIEARDCRFLPFVTVVQDRADVVIMNMDPVMHDIQAYETSHLGPRVLFNTPLPMNPHHKRNVGADSHEHLAGEPIKETIRMTKGRKFFVMQCGFHAYMESWGLAVENPYYHVTGKDGSFSLTDVPAGEYLLTAWHPGVGIVLEQKITVPAKETVRADFLFESPKGRRSAHEIEENPHFGLQALGKSVDIRPTLELQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I030</accession>
    <name>A0A1W1I030_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46332">
        <property type="protein sequence ID" value="SLM46332"/>
        <property type="gene ID" value="NSJP_0160"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0160"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="138" mass="14122" checksum="290A287CD947FD1E" modified="2017-06-07" version="1">MQDTIIDFALGAAAGGLGLSLCWGLFWLVVGSIGLTRGTCTWRVVANSALVGGLPLVLGAGLFWARGGIQSTGLFTLGLLVMPLVLLVLGLRNAPDGQRAGVHVFAGMRHLMEELLGGHRGCGGCDHEHESGDAGGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I054</accession>
    <name>A0A1W1I054_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46364">
        <property type="protein sequence ID" value="SLM46364"/>
        <property type="gene ID" value="NSJP_0192"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0192"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010746333" evidence="1">
        <location>
            <begin position="43"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="120" mass="13766" checksum="62E7DA917CE89016" modified="2017-06-07" version="1">MPSPRPPFQTLHTVARFSSRRRTVRIIALIGLLSCVARSVEAADPPCDRYPPAKQARCADIWKGLNREDGPAIAQFGLEQQRRREAGQLTAEQHLAQNMEFIKRSTERRLERLKERMANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I077</accession>
    <name>A0A1W1I077_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0210"/>
    <dbReference type="EnsemblBacteria" id="SLM46382">
        <property type="protein sequence ID" value="SLM46382"/>
        <property type="gene ID" value="NSJP_0210"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0210"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454">
        <property type="entry name" value="PTHR36454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06245">
        <property type="entry name" value="DUF1015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033563">
        <property type="entry name" value="UCP033563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="441" mass="48733" checksum="D1CB34F0BCB0F951" modified="2017-06-07" version="1">MAHIIPFRGTLYDQATVGSVREVVAPPYDIIDAAGQKALHDRHSHNIIRLELGTDKPGDSTGDNRYTRAAAALREWLKTGAMKRDAQPALYYHTIEYRPPDSAADAPVKVLRGFLVTTKLEPLDSGHIYPHENTRAAAKTDRLNLLEACRANLSPIWLLYSDPQNAVLDLLENTVKGVPARIDFRDDEGCRQQLWAVTDPAVLKQVVDLMESKPLFIADGHHRYETALNYQRARRQQASGTSSGLHPYDSVLMLLAPLEDPGLTVLPTHRVTTTPLPPYERLKSQLSEKFALKEFPFTRNDKSAVRAQFIESLRNLGRTAPTFGLSVRGLASYVVLTLLPAHRPDSGASPRTKLDVSLLQQLVVPVLCPTQQEQEAIVYTKDDAEALDWAQDGPGTGALLLNATKVSEVQAVAVAGERMPHKSTYFYPKPLTGLVINVMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I079</accession>
    <name>A0A1W1I079_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0243"/>
    <dbReference type="EnsemblBacteria" id="SLM46415">
        <property type="protein sequence ID" value="SLM46415"/>
        <property type="gene ID" value="NSJP_0243"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0243"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="319" mass="36646" checksum="79554D71EADAC898" modified="2017-06-07" version="1">MTDPLITVVICTYNRAGLLAGALQTVCAQTLEGSRYEILVVDNNSTDDTAQVVGQWQHGPATVRYVFESKQGLSFARNRGYEEARGEYVAYLDDDCKVTAGWLATAVRVIEKEKALIFGGPYFAFYDTEKPKWFRDEYGSHVQGDVSRALTDQEYLDGANMFINRRLLQGLGGFNPRFGMAGNDLGYGEEVRFQRHAREHRAGLAIRYEPELYVHHLVSRKKMTLRWKLHQMFVMGHAWHRLIHEGVRDLATVTDVLKEAVRTIRALCLDVVRGVLRRDRSRYRFLQNYLYEHSFVSVHRLGQLHEQFIGLMAARRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0C3</accession>
    <name>A0A1W1I0C3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Replicative DNA helicase</fullName>
            <ecNumber evidence="3 12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">dnaC</name>
        <name evidence="14" type="ORF">NSJP_0262</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 12"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0262"/>
    <dbReference type="EnsemblBacteria" id="SLM46434">
        <property type="protein sequence ID" value="SLM46434"/>
        <property type="gene ID" value="NSJP_0262"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0262"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 12" id="KW-0639">Primosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="13">
        <location>
            <begin position="184"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM46434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="451" mass="49930" checksum="1B47A54B11EE3B7C" modified="2017-06-07" version="1">MKSAPDIDLSQPKLPPQNVEAEQSVLGAVLLDNQAMAKAMELIVENDFYRTAHRKIYHAMVELSEIGEVIDQITLTERLKAQGELEAVGGAAYLAELVQIVPSAANIRYHSKIVRDKALLRELIHTSTEVLTRGYEGATQIDDLLDFAERSVFAIAQGKLDRSFSPINQIIKESLDLVDKLSKRKEQVTGVPTGFYDLDDLTAGLQPSDLVVIAGRPSMGKTSLVLGMAAHAALHAGTSVGIFSLEMSKPQIVLRMLSSEARVDSHALRTGKLQKEDWWRLAEAAGRLEQAPIYIDDTGGITVQQMRGKARRLKAERGLGLLVVDYLQLMQGRSDAESRQQEISDISRSLKALAKELNVPVVALSQLSRAVEARKPPIPMLADLRESGAIEQDADVVMFIYREEVYDQNSERKGIADILVSKHRNGPIGKKELFFHDRFAKFESLDNREAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0U5</accession>
    <name>A0A1W1I0U5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bacterioferritin</fullName>
            <ecNumber evidence="2">1.16.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.16.3.1" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0456"/>
    <dbReference type="EnsemblBacteria" id="SLM46628">
        <property type="protein sequence ID" value="SLM46628"/>
        <property type="gene ID" value="NSJP_0456"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0456"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014490">
        <property type="entry name" value="Dps-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018063">
        <property type="entry name" value="Ferrtn_UCP018063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="1">
        <location>
            <begin position="30"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="183" mass="20246" checksum="D37E6B26971A851C" modified="2017-06-07" version="1">MKRPLASQSGLTDQEIQDAVDQGAVTKQYFADPQNVVSSLNRLRSTEITSYLQYKQHGYMAVSLLSPGLKGEFEAHAQQELAHADKLAMRIQQLGGVPIFDLQELAGKAAAIGIHPEQGATLTEMVIENLLLERRQVEAYTALIREIGDKDLVTRETLLGILAETETHASELADFLKRTSDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0X2</accession>
    <name>A0A1W1I0X2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46632">
        <property type="protein sequence ID" value="SLM46632"/>
        <property type="gene ID" value="NSJP_0460"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0460"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014509">
        <property type="entry name" value="UCP020606"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09997">
        <property type="entry name" value="DUF2238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020606">
        <property type="entry name" value="UCP020606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="213" mass="24280" checksum="F64C3CB446FAD063" modified="2017-06-07" version="1">MVRTNKRILFGLLVWYVLLSAWTAYAPVDRQFWLLASILPGFLVFLLAGTHRYLPLSVASYVLITVFLSLHTVGVHYTYAQVPLGSWMEVTVDTGRNHYDRLVHFCFGFLLVYPIEELFRLTASVRGWMTYYLPVMTILGLSGLWEIIESWVARAVHPELGISYLGSQGDIWDAQKDMAAALYGGLLCTAVLMLVRWYRHGRLFSHGQTLVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I123</accession>
    <name>A0A1W1I123_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46533">
        <property type="protein sequence ID" value="SLM46533"/>
        <property type="gene ID" value="NSJP_0361"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0361"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="141" mass="15091" checksum="43D4A5A85F54B7BE" modified="2017-06-07" version="1">MSLKCRMPIGAGLVALVLLIGQYAYGAFGSGAITSIDKSGLVTATDLKTKQVFSFQVTDPKLLRSLKMGQLVYADFNKQQVSLDSLNPCCPIVKPQSSKQLRGPMEGGPVLDPNAPNQVRPLPQEPMQAPPNRSLQPGVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I190</accession>
    <name>A0A1W1I190_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="5">4.1.2.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Queuosine biosynthesis protein QueD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_0585</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.50" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0585"/>
    <dbReference type="EnsemblBacteria" id="SLM46757">
        <property type="protein sequence ID" value="SLM46757"/>
        <property type="gene ID" value="NSJP_0585"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0585"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM46757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="250" mass="28074" checksum="BEB89DFCEA3BBA90" modified="2017-06-07" version="1">MAPVLLTKRIEFAAAHRYFRPEWDEAKNRAVFGRCYNPPAHGHNYMLEVTVSGGVDPQTGMVINLFDLKRVLLGMIEEFDHKNLNLDMSYFTDRIPTSENLARVLWTKLEPQSDIGTLHAIRLYEDEDLFAEITAAGGLDIAGVTRRYSFTAVQEGHQGRQWDCFVTVQGPIDPKTGMVVDIAALNLLVQEHVLAKLDCRDLRDVFGRTSVTGQSLVEFIWTSLVSRIPSGKLAHLQVVHSRDLSFSCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1B7</accession>
    <name>A0A1W1I1B7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Micrococcal nuclease</fullName>
            <ecNumber evidence="3">3.1.31.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nuc</name>
        <name evidence="3" type="ORF">NSJP_0623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.31.1" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46795">
        <property type="protein sequence ID" value="SLM46795"/>
        <property type="gene ID" value="NSJP_0623"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0623"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002071">
        <property type="entry name" value="Thermonucl_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01123">
        <property type="entry name" value="TNASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="2">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="175" mass="19625" checksum="5A0E3F1A477DBDC6" modified="2017-06-07" version="1">MGLRATVICVLLILAPVIGWADFSGEVVGVLDGDTIEVMHRQQAERIRLHGIDCPEKGQAYGTRAKQAASALVFGKEVTLRTHGMDKYGRTIADVLLPDGTNVNQQLVKEGWCWWYRKYAHKDVTLEHLEQAAREAQSGLWADPQPVPPWEYRKASRGKKPAWLDLEPEAELPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1H6</accession>
    <name>A0A1W1I1H6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetoacetate metabolism regulatory protein AtoC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atoC</name>
        <name evidence="9" type="ORF">NSJP_0688</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46860">
        <property type="protein sequence ID" value="SLM46860"/>
        <property type="gene ID" value="NSJP_0688"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0688"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="9"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="149"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="462" mass="50784" checksum="865815D2E5C69F80" modified="2017-06-07" version="1">MPTPLASDTILVVDDDPVIRRNLRTLLESEGYRVMEADNGVAAAGMLDDPAIALVLLDLKMPGGSGLDLLRDSQDRLDERPVIVLTALGGSSAAIEAMKLGAYDYITKPFDLDEVLYTVRRALAQTALVAQVRALTSDDRDSALPDDELIGHSPEMLEVFKTIGKVAATTEPVLILGESGTGKELVANALRRNSSRAQAPFVKVNCAAIGPTLLESEFFGHERGAFTGAVARRIGRFEQANGGTLFLDEIGDLDLDLQAKLLRAIQHGQFERVGGHQTLTSDVRIIAATNRPLHAMTTEGRFREDLYYRLNVVTIEMPPLRARGEDIILLAKYLIGQLAGKYRWPQLALSPDAQQILRQQSWPGNVRELQNVLARAAILTRGRPIQPGDLRVTEPAPQGAASDSHARPSLLLKDILAETERRVIQQALEQTSWNRTHAARLLGISRRQLFDKIHEYGLEHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1J4</accession>
    <name>A0A1W1I1J4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_0693</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0693"/>
    <dbReference type="EnsemblBacteria" id="SLM46865">
        <property type="protein sequence ID" value="SLM46865"/>
        <property type="gene ID" value="NSJP_0693"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0693"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="63"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="155" mass="17116" checksum="F0A5DE51CDE13E85" modified="2017-06-07" version="1">MAGFFFHRAGFARRLLVTMGLAGGLGWTTPAMGTDEAVLKPRVPTDQMEEARGWKNPFEATEDNIDKGKALFQGKAFCVTCHGRDGKGFGDIPGLVGKLPRNFTDKLWQAARTDGELLWILKHGSPGTDMASFIPLVLTEEEAWQVLLYVRSFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Q4</accession>
    <name>A0A1W1I1Q4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">infB</name>
        <name evidence="11" type="ORF">NSJP_0766</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0766"/>
    <dbReference type="EnsemblBacteria" id="SLM46938">
        <property type="protein sequence ID" value="SLM46938"/>
        <property type="gene ID" value="NSJP_0766"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0766"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="336"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="96"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="G-domain" evidence="7">
        <location>
            <begin position="339"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="345"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="391"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="445"/>
            <end position="448"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM46938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="837" mass="89151" checksum="1E130B7F41EEC7BD" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1T0</accession>
    <name>A0A1W1I1T0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0772"/>
    <dbReference type="EnsemblBacteria" id="SLM46944">
        <property type="protein sequence ID" value="SLM46944"/>
        <property type="gene ID" value="NSJP_0772"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0772"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37953">
        <property type="entry name" value="PTHR37953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="164" mass="18486" checksum="78D4A65EED609610" modified="2017-06-07" version="1">MSTPQPIDRQQRKSRIITLVLLAILLMSLSTFLVQREDAKTIIVTFPTGTELEAEVADTPEKLLFGLAFQEALPPNGGMIYIFEQAGAHRVTTKEYRFAVDLIWIDEQHQVVQLLEKVEPCRKDPCPWYGPPPVAVRYLIEAAAGFIKEKGVGVGDELKYTLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1V4</accession>
    <name>A0A1W1I1V4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske iron-sulphur protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_0800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0800"/>
    <dbReference type="EnsemblBacteria" id="SLM46972">
        <property type="protein sequence ID" value="SLM46972"/>
        <property type="gene ID" value="NSJP_0800"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0800"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="328" mass="37309" checksum="4C6CA0F6433F4128" modified="2017-06-07" version="1">MLKGTILLGLPIVVCKTDHGVVAAMRDICPHRGMPLSFGRMRGDCVECAYHGWQFDPKGRCRTIPALVQDSPVQTDKIGVTNYPCRERDGYVWVFIPDSQRPDQPIPDVPPLPLPSTSYRMIQLSTLLDCAIDDGIVGLIDPAHGPFVHQSSWWRTAAEMREKAKTFEPIPYGFRMVPHAASMNSAYKLLNRLYPGPLMTTIDFVLPNQRFEFVQIGNTFMSNRTTVTPISDQQCRIDFCAAWNTLKWLPFAKTLFRYFGNMFLSQDKLAMERQAVGLRYKPAMMLIDDADTPAKWYYKLKAAHLDSLQTGLPLDHPLKGRVTLRWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1X3</accession>
    <name>A0A1W1I1X3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine 3-dehydrogenase, NAD(P)-binding</fullName>
            <ecNumber evidence="4">1.1.1.103</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tdh</name>
        <name evidence="4" type="ORF">NSJP_0823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0823"/>
    <dbReference type="EnsemblBacteria" id="SLM46995">
        <property type="protein sequence ID" value="SLM46995"/>
        <property type="gene ID" value="NSJP_0823"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0823"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="12"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="344" mass="36534" checksum="4E80FE5C0AE9FC2F" modified="2017-06-07" version="1">MRALLKREAKPGLEFTTCPDPTPGPTDAVVRVRATSLCGTDAHIYNWDPWAHSRIHPPRIIGHEMCGEVVETGADVTLVAVGDYVAAESHLTCGQCFQCRTGQAHVCRNYRILGVDRDGSFAEYVVLPENVLWKTAPTVPPELASVQEPLGNAVDAALVEDLTGHTVLITGCGPTGLFAAAVARTAGAATIIASDVSEYRLALAKQVGVDHVLNARAEVSDTLASNIRDITAGEGVDASLEMSGDPNALHLAFGAVKNGGRVTLFGIPTGLVTCDLANEIIFKGIRVHGITGRRLFSTWYRLAGLFKAGLNIKPVITHTFPLSGFAQGFDLMRSGQCGKVVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I226</accession>
    <name>A0A1W1I226_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47047">
        <property type="protein sequence ID" value="SLM47047"/>
        <property type="gene ID" value="NSJP_0875"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0875"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="281" mass="30295" checksum="BC882A1A04011AC8" modified="2017-06-07" version="1">MILPSIRPVRFLLGVLTLSVMLTWALAGPSFPALPDNAEPAPTDSTDQTEPDSVGSQEIADPSITLRGSVWRTKAGIVFLRTPIGTLTLSSKSTLKDLKASHEVRFWVHERHSVVDIVKKSDGSRIHRYLAGPMTPGSDVPNSLQWWTPDGDETTHVGTQQARLAAFQEGDTLTVEVDDSRTIIGVHDLQYDLQISQVPPAGSDAHVVLSGSVSKLKSNFVFLRTPVGVVMVNSKIGVPHVKVGQPMTVRIDGQRVTVDLDRGAPSSQDQHVPAPSSAPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I242</accession>
    <name>A0A1W1I242_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Potassium-transporting ATPase potassium-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP phosphohydrolase [potassium-transporting] A chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-binding and translocating subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-translocating ATPase A chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">kdpA</name>
        <name evidence="10" type="ORF">NSJP_0893</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KdpA family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0893"/>
    <dbReference type="EnsemblBacteria" id="SLM47065">
        <property type="protein sequence ID" value="SLM47065"/>
        <property type="gene ID" value="NSJP_0893"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0893"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00275">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="PTHR30607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001294">
        <property type="entry name" value="K_ATPaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00680">
        <property type="entry name" value="kdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 9" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="566"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="601" mass="63331" checksum="EEA0684D244511DF" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I286</accession>
    <name>A0A1W1I286_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Oxidoreductase with FAD/NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0946"/>
    <dbReference type="EnsemblBacteria" id="SLM47118">
        <property type="protein sequence ID" value="SLM47118"/>
        <property type="gene ID" value="NSJP_0946"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0946"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004792">
        <property type="entry name" value="BaiN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023166">
        <property type="entry name" value="HI0933-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42887">
        <property type="entry name" value="PTHR42887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00275">
        <property type="entry name" value="TIGR00275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="419" mass="45705" checksum="0500E954C3C57409" modified="2017-06-07" version="1">MSMRTADVVIVGAGAAGLTAALFATQARATKSRVVLLDGAATVGVKILVSGGGRCNVTHHTVTAADFFGNRRVIKNVLAGFPVQDTIAWFASLGVTLKREETGKLFPVTDKARTVLTSLVSSCQARGVDILCRHRVSRIDRVPDPRDGYLFLVHHSQGSMAAQKVILAMGGRSLPKSGSDGMGYVMAERLGHRVSPTSPALVPLVLDEGMFHQRLMGLSQIVRLTTVIDGKRVDQRIGSLLWTHFGVSGPVVMDASRFWTLARHQGQDAEIFANFLPDSRSEDIDQWLVEQTMQSSQRTVAKILSQRVPLRFAEEVGRHVGCDPSRLLAQCPRQDRLRLVDALSRLRLPIVRDRGWNYAEVTAGGVPLEEVDYRTMESKLVSGLYLIGEMLDCDGRIGGFNFQWAWATGSLAGRAISGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2G4</accession>
    <name>A0A1W1I2G4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1010"/>
    <dbReference type="EnsemblBacteria" id="SLM47182">
        <property type="protein sequence ID" value="SLM47182"/>
        <property type="gene ID" value="NSJP_1010"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1010"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="147" mass="16084" checksum="AB99E430E44228A1" modified="2017-06-07" version="1">MKALFQTSEDWTGMILRLTLGLVIFPHGAQKLLGWYGGFGFSGTMGFFTESMHLPWIIGFLVIIGEFFGSLGLLAGLLTRFTAASLSVIMLGAILTTHLPYGFFMNWFGKQQGEGYEYHLLAIGTGLALLVTGGGRWSLDRAIAERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2G9</accession>
    <name>A0A1W1I2G9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5069 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47184">
        <property type="protein sequence ID" value="SLM47184"/>
        <property type="gene ID" value="NSJP_1012"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1012"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031849">
        <property type="entry name" value="DUF5069"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16798">
        <property type="entry name" value="DUF5069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5069" evidence="1">
        <location>
            <begin position="18"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="154" mass="17886" checksum="ECDA6BAED389E343" modified="2017-06-07" version="1">MKANLAKVKQLAKDLRKDYPRSPREKLGGYVIAARSADKCRAFLLDMNGEYNYWPCSLASQWFSFTGITPEQFKEVVATGATDEELSKWIEGASAVKDPDAVLKWNNTMRDMKLSEMSLQAQRYLEEYIPQFVPPPRPVYVWFDVYDLEERRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2K4</accession>
    <name>A0A1W1I2K4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1066"/>
    <dbReference type="EnsemblBacteria" id="SLM47238">
        <property type="protein sequence ID" value="SLM47238"/>
        <property type="gene ID" value="NSJP_1066"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1066"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="151"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="310" mass="33588" checksum="BFCBB5EEC6A3DCC7" modified="2017-06-07" version="1">MKLDHVLLATDFSSPAQRAEEYACFFAARKHARLTVISVLEFAAGMDPAYPVNHQYLTERMQEASVLLTEAKQRIANRGISASTRIETGPPSEAIVAAALTEAVDFIVLGTSGRSGLAHVLLGSTAERVISRAPCPVLAVRSTGGTEMALKRILVPIDFFDCSLDAAEYAAQMANESGSAIRLLHVMEPVSYGLDFTLGDATDLARVRERRLRQLEELATALVAAGISTTSVIRGGIPRNAILEESRQWSSDLIVMGTHGRRGISHLLNGSVAEAVLRQADCPILAIRSPKFHPDHRRLIPVSVRQSLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2M9</accession>
    <name>A0A1W1I2M9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0901"/>
    <dbReference type="EnsemblBacteria" id="SLM47073">
        <property type="protein sequence ID" value="SLM47073"/>
        <property type="gene ID" value="NSJP_0901"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0901"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014845">
        <property type="entry name" value="GYD/TTHA1554"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08734">
        <property type="entry name" value="GYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="97" mass="10884" checksum="F3AA39E77FA0A5AF" modified="2017-06-07" version="1">MVTYVMLLSWTDQGIKNVKDSPKRLDAVKKLAKELGGEVRSFYMTLGQYDLVLILDMPNNDKQAAFALKLGSSGNVRSTTLKAFPEEDYRRILGTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2W1</accession>
    <name>A0A1W1I2W1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DksA C4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1162"/>
    <dbReference type="EnsemblBacteria" id="SLM47334">
        <property type="protein sequence ID" value="SLM47334"/>
        <property type="gene ID" value="NSJP_1162"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1162"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="5">
        <location>
            <begin position="51"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="137" mass="15967" checksum="7444DC4D6391A18A" modified="2017-06-07" version="1">MNKTTTETERQSDVLRALLLERRATLQREIDRLIAQHRDQHGHFQDSSVLDLEDMSLRDATAAQQIALLEARTRQRIQLDEALRRLDEGTYGVCEDCEEPISAGRLRALPFARRCVACQEQFEVFERIVQREDREEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3A1</accession>
    <name>A0A1W1I3A1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Histidine kinase</fullName>
            <ecNumber evidence="6">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1141</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1141"/>
    <dbReference type="EnsemblBacteria" id="SLM47313">
        <property type="protein sequence ID" value="SLM47313"/>
        <property type="gene ID" value="NSJP_1141"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1141"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="142"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="308"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="532" mass="57880" checksum="BB5F6D4451D5919C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3C3</accession>
    <name>A0A1W1I3C3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">recR</name>
        <name evidence="9" type="ORF">NSJP_1345</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1345"/>
    <dbReference type="EnsemblBacteria" id="SLM47517">
        <property type="protein sequence ID" value="SLM47517"/>
        <property type="gene ID" value="NSJP_1345"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1345"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
        <property type="entry name" value="RECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="82"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="200" mass="21965" checksum="C134EFC9A76F81D4" modified="2017-06-07" version="1">MAVDQQGLLARLVRELVRLPGIGQKTAQRLAFHLLKAEREDALRLADAVRAVKDGLSFCQQCRNIAEGDLCEFCLDPKRDRSRILVVEEPSTLYAIERAGGYRGLYHVLLGALSPLDGVGPSDIRAEELIDRVKLGGIAEVILATNPTIEGEATAIYLTNQLKPLGTRVSRIAYGIPVGMDIEYADEVTLLKSIEGRREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3G1</accession>
    <name>A0A1W1I3G1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47532">
        <property type="protein sequence ID" value="SLM47532"/>
        <property type="gene ID" value="NSJP_1360"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1360"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="69" mass="7258" checksum="3A81F1E368FE9430" modified="2017-06-07" version="1">MGSGPKVLAAREPDRRSVRGPASHLYLPADGSILTDHERLSMCVRSLCGAPAAGSSFRSLVSPSIRIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3M5</accession>
    <name>A0A1W1I3M5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Manganese transport system ATP-binding protein MntB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mntB</name>
        <name evidence="5" type="ORF">NSJP_1428</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1428"/>
    <dbReference type="EnsemblBacteria" id="SLM47600">
        <property type="protein sequence ID" value="SLM47600"/>
        <property type="gene ID" value="NSJP_1428"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1428"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="263" mass="29115" checksum="B8EC9AAEB0A5A8D1" modified="2017-06-07" version="1">MSLRSQAIIRFDHATFQFPGVVALEDVSLDIHEGEFIGVIGPNGSGKTTLCRAVLGLMPPTSGHLRIFDCACDKLRCHHRARIGYLPQKGVVDRHFPVTVLETVMMGRYGALGLFARPTKRDRDIAVEALAHVGMEGHRNTGLGQLSGGQQQRVFIARALAQQPKVLLLDEPTTGLDIPTQHSVIDLVQKLHNELGLTVLLITHDINMIRSRVDRLVLLKTRLFASGPPAEVLKPDILRLVYGKDVVITAHDTILVEDYHHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3P5</accession>
    <name>A0A1W1I3P5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">pyrE</name>
        <name evidence="5" type="ORF">NSJP_1291</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1291"/>
    <dbReference type="EnsemblBacteria" id="SLM47463">
        <property type="protein sequence ID" value="SLM47463"/>
        <property type="gene ID" value="NSJP_1291"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1291"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="135"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="200" mass="21526" checksum="F14704737678D981" modified="2017-06-07" version="1">MTIGDSTMTEMKGELARAFHETQSFKWDSQKGFVLASGERSPYYVDCRSLMAHPSARRLVGMLANEALVGSDIDCLGGLEIGAISIATTISDCGYQAIPRRDWRTFVVRKQAKDHGLGKLVEGAARPGDRALIVDDVLTSGGSLLKAVAAARGMGLIVRQALVIVDRKEQNGRARVEQEGVSLIALLTIEDLTRQGATPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3T0</accession>
    <name>A0A1W1I3T0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integration host factor (IHF), DNA-binding protein, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ihfB</name>
        <name evidence="2" type="ORF">NSJP_1482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1482"/>
    <dbReference type="EnsemblBacteria" id="SLM47654">
        <property type="protein sequence ID" value="SLM47654"/>
        <property type="gene ID" value="NSJP_1482"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1482"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="92" mass="10392" checksum="C014F632DE13C4BA" modified="2017-06-07" version="1">MTKAQIIERVSEQVTTLTKRQAEIVVNTIFDCVRDSLKNGDKTEIRGFGSFRLRARRMKEGRNPKTGATVAVPAKKVPFFKAGKELKELLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3U1</accession>
    <name>A0A1W1I3U1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">msrA</name>
        <name evidence="6" type="ORF">NSJP_1515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1515"/>
    <dbReference type="EnsemblBacteria" id="SLM47687">
        <property type="protein sequence ID" value="SLM47687"/>
        <property type="gene ID" value="NSJP_1515"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1515"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="6"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="178" mass="20087" checksum="D65B27EA48E6461E" modified="2017-06-07" version="1">MEHNIAILAGGCFWCLEAVYDQLQGVHSVESGYIGGKTENPTYEAVCGGQTGHAEAVRITFDPRVLDYRTLLQIFFVIHDPTTLNRQGHDVGTQYRSAIFYQTPEQKRIAYETIALLTAQQIYANPVVTEVVPAGRWHEAEPYHQEYFARNPFQGYCTAVVGPKVAKFRKQFADKLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I426</accession>
    <name>A0A1W1I426_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA translocase FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ftsK</name>
        <name evidence="12" type="ORF">NSJP_1584</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1584"/>
    <dbReference type="EnsemblBacteria" id="SLM47756">
        <property type="protein sequence ID" value="SLM47756"/>
        <property type="gene ID" value="NSJP_1584"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1584"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025199">
        <property type="entry name" value="FtsK_4TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13491">
        <property type="entry name" value="FtsK_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="11">
        <location>
            <begin position="427"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="787"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="444"/>
            <end position="451"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM47756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="808" mass="86184" checksum="AE57091162D42D37" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I498</accession>
    <name>A0A1W1I498_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="5">OTCase</shortName>
            <ecNumber evidence="3 5">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argF</name>
        <name evidence="9" type="ORF">NSJP_1527</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1527"/>
    <dbReference type="EnsemblBacteria" id="SLM47699">
        <property type="protein sequence ID" value="SLM47699"/>
        <property type="gene ID" value="NSJP_1527"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1527"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="13"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="160"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="5">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="275"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="323" mass="35416" checksum="AB05E4515EF625E7" modified="2017-06-07" version="1">MTRRSRRTSGLGKDLLDVAAIPRGEIEYLLTLAARLKDKQRRGLPHPLLQGKTLGLLFQKPSTRTRVSFEAGMNQLGGHALVLPMGDIQLSRGESVADTARVLSRYLDGIVIRTYNHATVEEWAAEATMPVINGLTDLSHPCQALSDLLTIREKKGRLRGLKIAYVGDGNNVANSLIEATAKTGMTIALGCPSGYQPDQHVIDRARLEAAGTGAAIELGHDPQIAVKEADVIYADVWISMGREREQARRLKVLAPYQVNARLVGRAKPDAIVMHCLPAHRGEEITEEVLDGPQSVIIDQAENRLHMQKAILTRLLGKRKQRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4D1</accession>
    <name>A0A1W1I4D1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Secretion protein HlyD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1663</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47835">
        <property type="protein sequence ID" value="SLM47835"/>
        <property type="gene ID" value="NSJP_1663"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1663"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="107"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="437" mass="48218" checksum="4883279D3872A00E" modified="2017-06-07" version="1">MRSPKEGLSIPGERKIPLQVKAPITHRCIVIGLVLSAVLSYGCKERSADREAGAPGKKSAQAATQTDEPESTGSRVEDGEPMHQLTIPPQALSGQAFQTAVVERRVFQDDIQATANIKPNEYRLTHVSPRVEGRVMEVLVQLGDQVKVGQPLALFDSIELGQKKSTFLQAKTDRDVDERNYVRVQGLYEQRISSEKEYLEAKGQHEKSLAAYQAAYEALRLIGLSEEEIKRITWSEKGKQLSRFALLAPQAGTVIERPITRGELVAPKDNAFTVADLSTVWFLVDIYERHVAAVKVGSEVKIAVDAYPDEFFRGKIVYVGYVLNSDTRTVDGRVEIANPDRRLRPGMFARAALTIPAGKDGQAVVLVPQDAIQRIDENSMAFIEERPGSYLAQPVIIGRQSGHDVEIRSGLTEGQKVVTQGSFYLKSILLKERIAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4E7</accession>
    <name>A0A1W1I4E7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47880">
        <property type="protein sequence ID" value="SLM47880"/>
        <property type="gene ID" value="NSJP_1708"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1708"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="21"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="130" mass="14065" checksum="F7C81F65372053F6" modified="2017-06-07" version="1">MMNTYPSDRPHDHPAVLRPTRRVTERVPSRFAVMYSGMQAGRMVMGDGLTANLSDGGVGICGDQGVTSGMELALFITVPGTDDPICLPQCRVSWVSGLRFGVELLSLSPEISNQLRFHTWNSSSRPSIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4G8</accession>
    <name>A0A1W1I4G8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="7">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">murE</name>
        <name evidence="12" type="ORF">NSJP_1728</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1728"/>
    <dbReference type="EnsemblBacteria" id="SLM47900">
        <property type="protein sequence ID" value="SLM47900"/>
        <property type="gene ID" value="NSJP_1728"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1728"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="9">
        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="11">
        <location>
            <begin position="111"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="10">
        <location>
            <begin position="335"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="155"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="7">
        <location>
            <begin position="410"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="7">
        <location>
            <begin position="410"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="113"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM47900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="500" mass="54054" checksum="3175A7F0CFAB3303" modified="2017-06-07" version="1">MTVEDLVSAARGQMEILEQRGDLRVPIGVVTDDSRAVVPGSLFVAVKGERVDGHEFVAKALHDGAAGVIAQSPVDTGIIPLVRVADSRKALGIIGSRFYGDPSSRLTMVGVTGTNGKTTTTYLCKALLEGIGRQVGLIGTVAYQIGEEVIPASHTTPGALTLQGLLARMLKAGLNAVAMEVSSHALALDRTAGCEYDVAVFTNLTQDHLDFHSTMEEYFQSKLKLFTELGRGRKSGQRAVVNMDDPRGSQVRAACRVPVWGYGMTGTPEIKAEQVKLSLNGTNFMAATPAGTFPVDSRLVGEHNVYNLLGAIGVALHAGATCEQVREAVTQVNNVPGRFERVSAGQDFTVVVDYAHTEDALRRLLAAAHELKTHRIITVFGCGGDRDRGKRPKMGRAAVEYSDVVILTSDNPRTEDPLAILREVEVGVHEALQRRKDVEYHLIADRRDAIATAVRMARSGDMMLIAGKGHEDYQIIGTTKIHFDDREVAREAIRHLRDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4H1</accession>
    <name>A0A1W1I4H1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47769">
        <property type="protein sequence ID" value="SLM47769"/>
        <property type="gene ID" value="NSJP_1597"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1597"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="86" mass="9860" checksum="B78458E54B1F1D60" modified="2017-06-07" version="1">MRILGQTGRSLIEIFKRRRMATLQPVDQHLHGPHEAPCEELEAGVEYGDGFISRMIQLSQMPRIRSPRDRNTFSIRSVPTRPAYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I570</accession>
    <name>A0A1W1I570_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1974"/>
    <dbReference type="EnsemblBacteria" id="SLM48146">
        <property type="protein sequence ID" value="SLM48146"/>
        <property type="gene ID" value="NSJP_1974"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1974"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012076994" evidence="3">
        <location>
            <begin position="26"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="438" mass="48087" checksum="2101B66DF02C78CA" modified="2017-06-07" version="1">MHRSVPVTTLAVFFTLLLPIDPSHAQTTDEPGAPPLLDSPPLVENQPLVESPPPVESRPLTPPPTEAPEPPVTAQEEDATLALSELRNAARLTPQNAETRLNLARGLYRIGDLDAAIDECRAAIKLNASDPEAHLQLGVLLMAKQDWRGASTALKEAIQLDSTLTHAHYSLGNVHYTRGNVNAAIDSYRQALELQPNFPDARYRMALLLKLVNHGGEAAQFMEEAAKGGVPQAQFFLGNAYKAGQGVQKNLASAIYWWAKAEEFGHQPAAEALSKTRRLALSPDQPERRRKETLEAFQAYQERVQVEVLEKIRQDQDLQPYQIENGETLGTTLLKHNRPDMAVPLLLKEAYALSEPSQAELAKLYETGLDQQLPPFDPVLLAYFETTAADGFVPSKKTLARIYGKGLGTAADLRKAKAVLKGLPKQEVKAVLEEFANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I592</accession>
    <name>A0A1W1I592_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="4">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pssA</name>
        <name evidence="9" type="ORF">NSJP_2016</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2016"/>
    <dbReference type="EnsemblBacteria" id="SLM48188">
        <property type="protein sequence ID" value="SLM48188"/>
        <property type="gene ID" value="NSJP_2016"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2016"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="267" mass="28825" checksum="A00A95AF4F714DBC" modified="2017-06-07" version="1">MKTTGLRQSFAKGGKRHKAAMHLIPNLFTTGNLFCGVFAILSVFNANYLAAAVAILVAMVFDVLDGKSARLTNSTSHFGLEYDSLSDVVSFGVAPGLLIYSWALSGQGTFGIAVMFAYVAMGAVRLARFNASATASDGKYFTGLAIPAAAGVVASLVIFDHHVVRTGSEIKPILVLIITLVLSFLMVSTIKYRSFKDLKFRGGRHITYLVWGILTVVLVAAWPQVMLFVIFAGYALLGPVERLITLVTRTGKQIQPKKEQPAVESKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I597</accession>
    <name>A0A1W1I597_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetolactate synthase III, large subunit</fullName>
            <ecNumber evidence="7">2.2.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ilvI</name>
        <name evidence="7" type="ORF">NSJP_2012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2012"/>
    <dbReference type="EnsemblBacteria" id="SLM48184">
        <property type="protein sequence ID" value="SLM48184"/>
        <property type="gene ID" value="NSJP_2012"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2012"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="193"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="393"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="592" mass="64696" checksum="5733609A867BA4A0" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5G7</accession>
    <name>A0A1W1I5G7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1901"/>
    <dbReference type="EnsemblBacteria" id="SLM48073">
        <property type="protein sequence ID" value="SLM48073"/>
        <property type="gene ID" value="NSJP_1901"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1901"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="123" mass="14329" checksum="1DD48D7587E69679" modified="2017-06-07" version="1">MANPKVIFVAFAIEDERQRDFLKGQSLNTQCPFEYVDMSVKEAYSSEWKERVRTRIRRSDGVIALVSRNSLNSSGQKWELQCARGETKPILGIWAYTHDRTYLPDLATIPWTWETIGRFINDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5I5</accession>
    <name>A0A1W1I5I5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="13">1.1.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">3-IPM-DH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Beta-IPM dehydrogenase</fullName>
            <shortName evidence="13">IMDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">leuB</name>
        <name evidence="16" type="ORF">NSJP_2019</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="13"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2019"/>
    <dbReference type="EnsemblBacteria" id="SLM48191">
        <property type="protein sequence ID" value="SLM48191"/>
        <property type="gene ID" value="NSJP_2019"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2019"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01033">
        <property type="entry name" value="LeuB_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="PTHR42979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 13 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0520">NAD</keyword>
    <keyword evidence="10 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="15">
        <location>
            <begin position="4"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="13">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="13">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SLM48191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="357" mass="38540" checksum="CE7418FCE74A1852" modified="2017-06-07" version="1">MKAKIAVLAGDGVGREIVPEAVKVLKVVAEKFGHTFDFAYGDVGGQAIDKVGVPLPQDTLALAKQSDAVLLGAVGGPKWEGLEYSLRPERALLGLREQLGLFANLRPAKLYEVLADASTLKKEVIEGIDILVIRELTGGIYFGKPKGIEALPNGGERGVNTEVYTTEEIRRIAKVAFEAARRRRKKVTSVDKANVLESSELWRRVVIAVQKDFPDVELNHIYVDNAAMQLVRNPRQFDVMLCNNIFGDILSDEAAMLTGSIGMLPSASIGAQVGLFEPIHGSAPDIAGKNIANPIATIASAAMLLSYAFKLDREAHAIEEAIVKTLDLGYRTKDIHSAGSRLVGTTDMGEAVVRNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5J5</accession>
    <name>A0A1W1I5J5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Regulatory protein, FmdB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48266">
        <property type="protein sequence ID" value="SLM48266"/>
        <property type="gene ID" value="NSJP_2094"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2094"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="114" mass="12293" checksum="1A44AD22A552C1E1" modified="2017-06-07" version="1">MPLYEYLCLSCRRRTTVLQLSIANPKPVSCASCGSAELSRLMSRFASPKSEEARLESLADPDTLGDLDESDPDSMKQFMKKMGDEMGEGFGEDPSEALGNTEDASADLGDDGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5M1</accession>
    <name>A0A1W1I5M1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin reductase, FAD/NAD(P)-binding</fullName>
            <ecNumber evidence="4">1.8.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trxB</name>
        <name evidence="4" type="ORF">NSJP_2124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.8.1.9" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2124"/>
    <dbReference type="EnsemblBacteria" id="SLM48296">
        <property type="protein sequence ID" value="SLM48296"/>
        <property type="gene ID" value="NSJP_2124"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2124"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="306" mass="32539" checksum="3C7E88AFBB06273D" modified="2017-06-07" version="1">MHDLIIIGSGPAGLTAAIYAARANLTPVLIEGWQSGGQLTTTTDVENYPGFPRGIMGPELMKDMRVQAERFGTVFQTGDVTAVDFTTRPFSVTMDGERSLRARTVIIATGAAPIQLGIKNESRLIGHGVSTCATCDGFFFRGKELMVVGGGDSALEEALFLTKFASKVSVVHRRDKLRASKIMQDRAIKNDKITFIWNTVVEDILGTEVVTGVKLKNVVTGHSAEIPCAGVFVAIGHRPNTSLFSGQLDMDPKGYLITSKGTATSVPGIFAAGDVQDSVYRQAVTAAGSGCMAAIDAERHLETLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I683</accession>
    <name>A0A1W1I683_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48451">
        <property type="protein sequence ID" value="SLM48451"/>
        <property type="gene ID" value="NSJP_2279"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2279"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="55" mass="6279" checksum="B7837E38E6EAEE19" modified="2017-06-07" version="1">MSPEEFFMYLTIGLIVIAPIGARLYRRMTLRRTQAMLREQFGHANAPERGPGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6A1</accession>
    <name>A0A1W1I6A1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ORF">NSJP_2360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2360"/>
    <dbReference type="EnsemblBacteria" id="SLM48532">
        <property type="protein sequence ID" value="SLM48532"/>
        <property type="gene ID" value="NSJP_2360"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2360"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="249" mass="26587" checksum="ED1380258732A15A" modified="2017-06-07" version="1">MIILKTPEEVALMAKASRVVAEALEVLKKAVKPGVTTDELDRLAEAEIRARGAQPAFKGYRNYPKTLCASVNEQVVHGIPSKRVLKEGDIVGLDLGAIVEGFYGDSAVTVGVGQVEDGAAKLVRVTEEALALGIEQAVVGNRLSDISHAVQRHVEAAGYSVVTEFVGHGIGRQLHEEPQVPNYGKPGQGPRLQHGMVLAIEPMVNMGRAAVRVLDDRWTAVTVDGSLSAHFEHTIAVQPEGPAKVLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6F0</accession>
    <name>A0A1W1I6F0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">nadE</name>
        <name evidence="9" type="ORF">NSJP_2398</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2398"/>
    <dbReference type="EnsemblBacteria" id="SLM48570">
        <property type="protein sequence ID" value="SLM48570"/>
        <property type="gene ID" value="NSJP_2398"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2398"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for glutaminase activity" evidence="5">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="For glutaminase activity" evidence="5">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutaminase activity" evidence="5">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="337"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="561"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="591" mass="64804" checksum="0FFF3E2B5E370E0A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6H4</accession>
    <name>A0A1W1I6H4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2403"/>
    <dbReference type="EnsemblBacteria" id="SLM48575">
        <property type="protein sequence ID" value="SLM48575"/>
        <property type="gene ID" value="NSJP_2403"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2403"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd13553">
        <property type="entry name" value="PBP2_NrtA_CpmA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044527">
        <property type="entry name" value="NrtA/CpmA_ABC-bd_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="452" mass="49910" checksum="090A90C8B67E58F9" modified="2017-06-07" version="1">MFEALVPNELEKEQTMNEPTPPRVLSPAPDALSPDEYFDRTLERSVAAAVLNAADPTRRQVLAGLGAAALTALIAELFPLGSLKAFAADPVGKPEKTDVSIGFIPITCGTPIIMAEPLGFYKKHGLNASVKRAAGWAMIRDWTVNEEVDAAHMLTPMPLAITLGAGSVPTPIYMPAIENINGQAITLHVKHKGVKSAAEMKGFRFCVPFDYSMHNYLLRYYLAEGGIHPDKDVQIRVVPPPEMVANLKAGNVDGYLGPDPFNQRAVYENVGFLYKLSREIWDRHPCCAFTVKKDYATAHPNTFLAMWRAIIDATHYASDPAHRKEIAAAIAPTNYLNQPVTVLEQVLTGTYADGLGSIKKDPHRIDFDPYPWHSMAIWILTQMKRWGHVKGDVNYKAVAEQVYRAADCDRIARELGYPAHQATSMTHVIMGKEFDPNKAEAYVKGFTIHSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6H5</accession>
    <name>A0A1W1I6H5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48479">
        <property type="protein sequence ID" value="SLM48479"/>
        <property type="gene ID" value="NSJP_2307"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2307"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="108" mass="12268" checksum="455B89BAD663557C" modified="2017-06-07" version="1">MADSPDKSVRNQVQTHLRASDRMLLSIEPHLLTEEMQIARDSIRRLKQMITLQQDRLKKARHQPGGSSSHARRLRASTVDALSICKLTLLQLKQSADQLKIAWASLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6I5</accession>
    <name>A0A1W1I6I5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nitrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nasA</name>
        <name evidence="9" type="ORF">NSJP_2438</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2438"/>
    <dbReference type="EnsemblBacteria" id="SLM48610">
        <property type="protein sequence ID" value="SLM48610"/>
        <property type="gene ID" value="NSJP_2438"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2438"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="15"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="400" mass="42081" checksum="FF15D175F953CAB5" modified="2017-06-07" version="1">MANVLWALRRGHWPSLIGAWLHFEVSFMTWLLIGSLGVSIAEELSLSATQKGFLVACPLLSGALFRIVVGLGSDYLGPKTTGLYVLFCEMVALLWGWTGGGTFSQMVGIGFMLGIAGASFAVALPLASRAYPPAHQGLVMGLAASANSGTVLAMFFAPRLAEWVGWRGVFGVMLAPVLVTVVLFAVLVRRDDAASAREVFPNWRRKLEESLARPAMYWLCLLYSVTFGGFVGVCSALPIFLHDQYRVDLVTAGSITALGGLLGSVIRPLGGYVADRVGGALVLPAVFMAIAASMVAVGTLPSLVPAVVCVMAAITAMGFGNGVLFQVVSDKFPKEIGMASGLIGAAGGIGGFLFPFGLGSLKDLTGTYAAGWWAFAAAAGCAWATVRLYNRRMNLPQRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6R2</accession>
    <name>A0A1W1I6R2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multidrug efflux system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">acrB</name>
        <name evidence="6" type="ORF">NSJP_2518</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48690">
        <property type="protein sequence ID" value="SLM48690"/>
        <property type="gene ID" value="NSJP_2518"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2518"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="540"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="870"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="895"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="925"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="974"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1000"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="5">
        <location>
            <begin position="370"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1048" mass="113808" checksum="0AC73D983559F4FB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6S6</accession>
    <name>A0A1W1I6S6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Redoxin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2549"/>
    <dbReference type="EnsemblBacteria" id="SLM48716">
        <property type="protein sequence ID" value="SLM48716"/>
        <property type="gene ID" value="NSJP_2549"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2549"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012009143" evidence="1">
        <location>
            <begin position="22"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="23"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="164" mass="18336" checksum="A1F5412344ADDF3C" modified="2017-06-07" version="1">MNQAIVSIAIFLLLLSSPADLLAAAAMPAPAFELVTFSGESYNNQTQKGRPALFVFWAPWCKVCQRDLPLLSEFYQHEKPTQLGVVSIGFADTRSNVERFVKERSGMFVYPTAYDEDRWVAQAFKVNATPTYVLMDDQGSIVLVHRGGGVLQNPQFREFLATLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6T9</accession>
    <name>A0A1W1I6T9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48748">
        <property type="protein sequence ID" value="SLM48748"/>
        <property type="gene ID" value="NSJP_2581"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2581"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="67" mass="7497" checksum="BFDA1152A158C7A9" modified="2017-06-07" version="1">MMESPRVTKEREHHMRADRLARALREMYSSTHILREDGHEQGNRESPGGTTAGDGRAAEGRRLPPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6U2</accession>
    <name>A0A1W1I6U2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxamine 5'-phosphate oxidase-related FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2547"/>
    <dbReference type="EnsemblBacteria" id="SLM48714">
        <property type="protein sequence ID" value="SLM48714"/>
        <property type="gene ID" value="NSJP_2547"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2547"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="2">
        <location>
            <begin position="10"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="190" mass="21839" checksum="43B3C4210C979F22" modified="2017-06-07" version="1">MAKFYTELNDGIRQFIAAQHMFFNASAPNEGRINVSPKGLDTFRILNDKQVAYLDLTGSENETAAHVAENGRLTLMFCSFEEKPSILRLYGKGRVVLPRDNQWQELYNHFPTIVGERQIVVLDIESIMTTCGFAVPLFEFKGQRTLLPDWSCKMGEERLNEYRRERNQRSIDGLPTYLNEQPPDSTHSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6U5</accession>
    <name>A0A1W1I6U5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2479"/>
    <dbReference type="EnsemblBacteria" id="SLM48651">
        <property type="protein sequence ID" value="SLM48651"/>
        <property type="gene ID" value="NSJP_2479"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2479"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13576">
        <property type="entry name" value="Pentapeptide_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012890390" evidence="2">
        <location>
            <begin position="26"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="352" mass="38522" checksum="D0E5DB632D67B4C1" modified="2017-06-07" version="1">MWMRAPVGVLAGCLLWVCMPAVVSAASCRIDTASDRASSTLKKRLSSDCTEHDRERYKVQAVEVLAAIKQGKSIDLAGVVIEGDLRLDELHLGALPPGSERQPIDPASTARVVPGALSVTHSIVRGAVRHGTERDALIVKGAVDLSGTRFERTVDLSHAEFLQPVTLSDAVCVRECYFVRAGFLRGLTAEGTAFGPHTRFHRARFHDRAAFRNARFNGLAEFLEVEFHPDADFTGSAFASGTGFSGSVFHGVADFSGARFEREAFFTFTRFEGDARFRGTVFRAIADFDDARFAGRDEFSGTVFEQEAKFARVTRRDQPPAPGGQDRPMQYGITLTLLVISAALIAYLIRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6V5</accession>
    <name>A0A1W1I6V5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATPase component</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">abcX</name>
        <name evidence="5" type="ORF">NSJP_2489</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2489"/>
    <dbReference type="EnsemblBacteria" id="SLM48661">
        <property type="protein sequence ID" value="SLM48661"/>
        <property type="gene ID" value="NSJP_2489"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2489"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="266" mass="29769" checksum="439F3E9ED7FCFF4D" modified="2017-06-07" version="1">MSFADDGIILDIRNATVYRGDTCVFDDLSFSLEEDHHTAILGPNGAGKSTILKLLAGEVHPVADDRMSIRVFGEAQWSVWDVRKRLGMVSHDLQHRYLDEVTGMKVVLSGFYASIGIYERQDFNYGQLARADEILADLGAQGLRDKPFGQMSTGEQRRCLLGRALVHDPPALVLDEPTSGLDLTATFHYLDLIRQHMQHGKTVLLVTHHIHEIPPEIKRVVLLKRGKILQDGEKRDVLTNANLSELFDCPVTLAQANGWYQAFPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6X6</accession>
    <name>A0A1W1I6X6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2509"/>
    <dbReference type="EnsemblBacteria" id="SLM48681">
        <property type="protein sequence ID" value="SLM48681"/>
        <property type="gene ID" value="NSJP_2509"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2509"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_molyb" evidence="1">
        <location>
            <begin position="68"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Mo-co_dimer" evidence="2">
        <location>
            <begin position="225"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="343" mass="38240" checksum="0468431DC9D7DD30" modified="2017-06-07" version="1">MPFSRRTILKAAGWGALAGMTGGCDDIGGIFGRMFAVPPRETTYFTPNGKFYVVNYADSAVSMSREINIEQWKLHVKGQVKTPLSLGWRDILNRDSYNQISTLMCIDTLPGGDSMGNATWRGISLKKLLQEAGADDETARDVIFRGIDGYDDSIPFKRAMQDDAMLAFLMNGEKLPKEHGFPIRLIVPGLYGIKNVKWIVEIEVYPGDHLGYWQRKGWTDDATIKVFSRIDSPGHYQTLRGPEQKFRGIAFGGPNSIGKVEISFDAGRSWNDCQIEPPMSPYSWVIWNYSWKPPKQGKFQTVVRATDTKGRLQIAEIVRPQPDGASGLHTIVAEVGTIENKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6X7</accession>
    <name>A0A1W1I6X7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurS</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit III</fullName>
            <shortName evidence="5">FGAR amidotransferase III</shortName>
            <shortName evidence="5">FGAR-AT III</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purS</name>
        <name evidence="6" type="ORF">NSJP_2447</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PurS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2447"/>
    <dbReference type="EnsemblBacteria" id="SLM48619">
        <property type="protein sequence ID" value="SLM48619"/>
        <property type="gene ID" value="NSJP_2447"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2447"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01926">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34696">
        <property type="entry name" value="PTHR34696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00302">
        <property type="entry name" value="TIGR00302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="79" mass="8906" checksum="CE7451FA2E623C54" modified="2017-06-07" version="1">MKAKVHVTLKQGILDPQGKAIEHALQSLGFQSASNVRVGKYMELDLNETDRAKAEALLKQMCEKLLANTVIEEYRYELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I707</accession>
    <name>A0A1W1I707_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48649">
        <property type="protein sequence ID" value="SLM48649"/>
        <property type="gene ID" value="NSJP_2477"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2477"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="152" mass="17032" checksum="A40354EE18F808BD" modified="2017-06-07" version="1">MSHFLFIAGALRERTSQESAEIQLSNGVWGLCSSLIRTNLQTYLEPHSRGLVYALKIGVCAEFKILPPVRDFSELDDFLKDELRTEARFGYVRIGEIRRRTLPSTVSQAVLLDVLQIPDQTELARRLSLGMHRVTQAEFDAIAAKLPADSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I782</accession>
    <name>A0A1W1I782_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48854">
        <property type="protein sequence ID" value="SLM48854"/>
        <property type="gene ID" value="NSJP_2687"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2687"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="208" mass="23320" checksum="6BD26DE3C2B9E423" modified="2017-06-07" version="1">MALILLLRSRNEGILADMKWLYPGLVAILGALVLTAYLTAAWSPSFKLSALWSQSSRPADSRGEAEKVAKGKTVLQDVLLEELRRTHHLRPLTEQESGMKIQNLPVGVFGFSECSESLESKRGGKPSLEVQKRRDGISYYVGYASDEDIEKYFARLKNFHILTFNQATGKAPSLLEIPIDFVAKCEARQLMEGPMFDLFVRDIPELQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I799</accession>
    <name>A0A1W1I799_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative TonB-dependent siderophore receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_2707</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48874">
        <property type="protein sequence ID" value="SLM48874"/>
        <property type="gene ID" value="NSJP_2707"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2707"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07660">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0798">TonB box</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="STN" evidence="10">
        <location>
            <begin position="157"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="924" mass="101057" checksum="42A946550B99BBD3" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7B7</accession>
    <name>A0A1W1I7B7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupredoxin_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48938">
        <property type="protein sequence ID" value="SLM48938"/>
        <property type="gene ID" value="NSJP_2771"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2771"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupredoxin_1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="97" mass="10650" checksum="A368D7192C41F051" modified="2017-06-07" version="1">MTTEDYRFVPNVLRVKAGSPFILALYNAGREDHEFVSPVLAYGTEKSGETMTLDTAAPGLLKPGRSLRFQVSAPPGTYLYSCRRKGHANMTGTLIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7C6</accession>
    <name>A0A1W1I7C6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2546"/>
    <dbReference type="EnsemblBacteria" id="SLM48713">
        <property type="protein sequence ID" value="SLM48713"/>
        <property type="gene ID" value="NSJP_2546"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2546"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="175" mass="19901" checksum="D9257E0A328E76EE" modified="2017-06-07" version="1">MKIVIIGNSGSGKTWLARELAGRACMPLIHLDEIFWEPGGFDKRRSSESMASLIRDSRLSESWVAEGVFGELAKDYLDDADTFIWLDLPWQICEARLRLRGCESKRHMSRSQSEQGLKDLLDWAAGYYSRGDLRSHEGHKALFDDFRGTKLWIKDEASVAMLLENSPAFQRGTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7F0</accession>
    <name>A0A1W1I7F0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48733">
        <property type="protein sequence ID" value="SLM48733"/>
        <property type="gene ID" value="NSJP_2566"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2566"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="142" mass="15221" checksum="A5E6D6C1EF937CC1" modified="2017-06-07" version="1">MSWLCSWLLGPEGLWVVICLFAYLAAVSNNPSTPAGNEFLESLWIAIPLVGVPLTFLTGYLPGGWSGRWLLRLIVASLFGVVVASFLAASGVDYHDSRNSGLMAAPFYSLTIGLFVLIPGAAIAAIAAILLFWRRNKAHGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7N3</accession>
    <name>A0A1W1I7N3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49010">
        <property type="protein sequence ID" value="SLM49010"/>
        <property type="gene ID" value="NSJP_2843"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2843"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="74" mass="8319" checksum="294F8D7DE1D723DA" modified="2017-06-07" version="1">MMGPLVQSLPRFPDLHTNIRGKQAPDKGLDHILTSSPRYVGLVSYVSELLPRRIDPSVDQTCKKQLSEFTVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7U2</accession>
    <name>A0A1W1I7U2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Sulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_2706</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48873">
        <property type="protein sequence ID" value="SLM48873"/>
        <property type="gene ID" value="NSJP_2706"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2706"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008476">
        <property type="term" value="F:protein-tyrosine sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006478">
        <property type="term" value="P:peptidyl-tyrosine sulfation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026634">
        <property type="entry name" value="TPST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788">
        <property type="entry name" value="PTHR12788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="587" mass="65626" checksum="A3C2FA856B5932EB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Z3</accession>
    <name>A0A1W1I7Z3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator, CheY like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3001"/>
    <dbReference type="EnsemblBacteria" id="SLM49168">
        <property type="protein sequence ID" value="SLM49168"/>
        <property type="gene ID" value="NSJP_3001"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3001"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="120" mass="13544" checksum="7DEF268BA1D47844" modified="2017-06-07" version="1">MATILVIDDEDSIRHLLKDVLEKAQYQVIEARDGQEGLHAYQKNRIDLVIMDILMPGTDGLEATLQLTREYVDAKVIAMTGAQGDRNFLDVAKLFGARRVFEKPFDLIKLVDAVKEELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I830</accession>
    <name>A0A1W1I830_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetolactate synthase</fullName>
            <ecNumber evidence="6">2.2.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_2796</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2796"/>
    <dbReference type="EnsemblBacteria" id="SLM48963">
        <property type="protein sequence ID" value="SLM48963"/>
        <property type="gene ID" value="NSJP_2796"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2796"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="191"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="382"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="547" mass="59896" checksum="C768F03FE69F9EB7" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I862</accession>
    <name>A0A1W1I862_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49238">
        <property type="protein sequence ID" value="SLM49238"/>
        <property type="gene ID" value="NSJP_3071"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3071"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="63" mass="6934" checksum="65F4C260954DAF12" modified="2017-06-07" version="1">MEDDDLFGRQRALSANVGHNSLEHCRRIPSHPDGQELLPDVPESVRATGLASQSKLRAVLTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8B5</accession>
    <name>A0A1W1I8B5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49244">
        <property type="protein sequence ID" value="SLM49244"/>
        <property type="gene ID" value="NSJP_3077"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3077"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="80" mass="9368" checksum="43CC7254A3B91E24" modified="2017-06-07" version="1">MSSTELVKTYCAYERVAGLESDHLERLRELYRVAPSSELKELENDMDKDIENRADCSEARRKIRSMLRVRGESEIVTCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8F2</accession>
    <name>A0A1W1I8F2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49328">
        <property type="protein sequence ID" value="SLM49328"/>
        <property type="gene ID" value="NSJP_3161"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3161"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012709515" evidence="2">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="66" mass="7008" checksum="FF70004B032EF9AE" modified="2017-06-07" version="1">MKTRVGVGVLILVLMALPAFAQVFPVDATSTTTIASVKTDLIAWGVAFIGVALTVFAYKRVKALVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8G0</accession>
    <name>A0A1W1I8G0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
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            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49307">
        <property type="protein sequence ID" value="SLM49307"/>
        <property type="gene ID" value="NSJP_3140"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3140"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="44" mass="5230" checksum="5B86FF6F3FBB7EDA" modified="2017-06-07" version="1">MDGQLTLYRVPIKYGDEALQREGYRKKVAGSRYNIALKVFIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8G3</accession>
    <name>A0A1W1I8G3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3127"/>
    <dbReference type="EnsemblBacteria" id="SLM49294">
        <property type="protein sequence ID" value="SLM49294"/>
        <property type="gene ID" value="NSJP_3127"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3127"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="255" mass="28360" checksum="FD18615D73260D10" modified="2017-06-07" version="1">MGSPAGGDGLPDEQPQRLVYVGSFYIDLYEVTNEAYGRFIASTGHPMPENSNPRATLWNDRHPFPGSERHPVVNVSWLDATAFCRWEGKRLPTEAEWEKAARGPDGRTYPWGDEWNPAWANSASYWAGRRIDFINSTEWEAFWIHGEGARIAKAKGLNGEVLTLPVGSFPEGVSAHGLHDMAGNVAEWVQDWYDPNYYRSAPLADPVGPERGAIKSMRGGSWLKPAVSLRTSDRDWGTMDSRPSGTGFRCAKDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8S4</accession>
    <name>A0A1W1I8S4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49193">
        <property type="protein sequence ID" value="SLM49193"/>
        <property type="gene ID" value="NSJP_3026"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3026"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="101" mass="10734" checksum="680821CE0DA26C4B" modified="2017-06-07" version="1">MANFPGVNVFPPSTVNLQSLPFDMQFVVIAQVSSFALPLEAVQEHLQWVVLNSGGSATLTAAVPTSMVRPRVPTTNTFTIALIALLLVILGSIAVDTRLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8T4</accession>
    <name>A0A1W1I8T4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49414">
        <property type="protein sequence ID" value="SLM49414"/>
        <property type="gene ID" value="NSJP_3247"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3247"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025427">
        <property type="entry name" value="DUF4160"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13711">
        <property type="entry name" value="DUF4160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="64" mass="7481" checksum="F0128BFECABE2D97" modified="2017-06-07" version="1">MPTVLHVKGYRFFFFSLEGKEPPHIHVEQAERYAKLWLAPVSIARAKGFRNNELTEILQIVQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8X3</accession>
    <name>A0A1W1I8X3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3321"/>
    <dbReference type="EnsemblBacteria" id="SLM49488">
        <property type="protein sequence ID" value="SLM49488"/>
        <property type="gene ID" value="NSJP_3321"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3321"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010266">
        <property type="entry name" value="NnrS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05940">
        <property type="entry name" value="NnrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="415" mass="44204" checksum="874663ED284D1AE7" modified="2017-06-07" version="1">MSSTPLNIQAGTSIPAADAEEEPSFPSYDGPPFLSYGFRPFFLSASLFAGLAVPIWVRLFAGAGSASFLYPPRDWHVHEMLFGFLSAVIAGFLLTAIPNWTGRAPLRGIPLLALWLLWLAGRLCLAVPAASPITVAALDASFLIVLASLLWRELYAVSARAQMPIAVMITLYAAANLLFHAAALRGLSTDLPERLVLALIMLLLTVIGGRLTPNLTREFLAQSGTARLPADFSRLDVVAMLSVLIAAVIWIVGPDLPAAGWAFIAAGVMNVARLLRWYGWVAYREPLVLILHIGYGWVAISLLVLGDTVLGAGMPQANALHTLTTGAVGAMTLAVMTRASLGHTGRAKRAGALTVVIYLLVNVGALLRILVPQSESPTALTHTILQLSAAAWSGAYLLFAVAYGPLLVRRSLDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8X7</accession>
    <name>A0A1W1I8X7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="8">ALP N-acyltransferase</shortName>
            <ecNumber evidence="8">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">lnt</name>
        <name evidence="10" type="ORF">NSJP_3214</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3214"/>
    <dbReference type="EnsemblBacteria" id="SLM49381">
        <property type="protein sequence ID" value="SLM49381"/>
        <property type="gene ID" value="NSJP_3214"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3214"/>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="237"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM49381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="541" mass="59797" checksum="D84E6C6DD26EE04C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I925</accession>
    <name>A0A1W1I925_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3264"/>
    <dbReference type="EnsemblBacteria" id="SLM49431">
        <property type="protein sequence ID" value="SLM49431"/>
        <property type="gene ID" value="NSJP_3264"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3264"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="124" mass="13195" checksum="77AE67460C0A4757" modified="2017-06-07" version="1">MLQSPGVLWIKAAVIYLIIGVGFGIYMGASGNHLLMPVHAHFNLLGWASLALVGLIYHHYPAAGSNRLATVQFWLHNIGLLVGMGLLVAVLRGNTSVEPLLGVASMVIGTAVVLFAINVLQRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I969</accession>
    <name>A0A1W1I969_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="5">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DTB synthetase</fullName>
            <shortName evidence="5">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">bioD</name>
        <name evidence="6" type="ORF">NSJP_3411</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3411"/>
    <dbReference type="EnsemblBacteria" id="SLM49578">
        <property type="protein sequence ID" value="SLM49578"/>
        <property type="gene ID" value="NSJP_3411"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3411"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006755">
        <property type="entry name" value="DTB_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="114"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="242" mass="26055" checksum="91305DAA23AE3063" modified="2017-06-07" version="1">MNSGIFITGTDTGVGKTIVTAALALHMKRKGIAVGVMKPIETGITSSGLARSDAARLQAVIESDDALGAICPFQFELPLAPLAAAQAERREIDLGVIQKVHRLMAGRYEYVVAEGIGGVHVPIGRNIDVFDLIARLRLPVVVVGRSGLGGINHALLTVEALRRRRIPVAALVLNQTRPARSKLERLQERTTVEILRKQAGVPVLGPLPYRSELSKQFRKTVTKLAQSAAITQLAKAVRRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I970</accession>
    <name>A0A1W1I970_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49353">
        <property type="protein sequence ID" value="SLM49353"/>
        <property type="gene ID" value="NSJP_3186"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3186"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="43" mass="4467" checksum="BCACCE5D3B322957" modified="2017-06-07" version="1">MDSKVVPAADQKSGSSVSLETVIAVGLFGWLALSMTLMGLGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9H0</accession>
    <name>A0A1W1I9H0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Histidine biosynthesis bifunctional protein HisIE</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <shortName evidence="15">PRA-CH</shortName>
                <ecNumber evidence="15">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Phosphoribosyl-ATP pyrophosphatase</fullName>
                <shortName evidence="15">PRA-PH</shortName>
                <ecNumber evidence="15">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">hisI</name>
        <name evidence="15" type="synonym">hisIE</name>
        <name evidence="17" type="ORF">NSJP_3465</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 15">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 15">In the C-terminal section; belongs to the PRA-PH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 15">In the N-terminal section; belongs to the PRA-CH family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="15"/>
    <dbReference type="EC" id="3.6.1.31" evidence="15"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3465"/>
    <dbReference type="EnsemblBacteria" id="SLM49632">
        <property type="protein sequence ID" value="SLM49632"/>
        <property type="gene ID" value="NSJP_3465"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3465"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11534">
        <property type="entry name" value="NTP-PPase_HisIE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01020">
        <property type="entry name" value="HisE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01019">
        <property type="entry name" value="HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023019">
        <property type="entry name" value="His_synth_HisIE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 15" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 15 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRA-CH" evidence="16">
        <location>
            <begin position="31"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosyl-AMP cyclohydrolase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosyl-ATP pyrophosphohydrolase" evidence="15">
        <location>
            <begin position="126"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SLM49632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="229" mass="25245" checksum="F4B3029D2240CDC3" modified="2017-06-07" version="1">MDSNSMTGLKLDEQGLLPAVIQDWLDGTVLMLGYMNQEAIGKTIATRSVHFWSRSRRSLWEKGETSGHKLIVKDLFIDCDRDTILVKAEQVGPTCHTGERACFFSRLDSQGRPQEARTTEASGGILDAVLRTIKERRAHPQAGSYTSKLFEGGQDKILKKVAEEAGEVLLAAKGGKKEEIIYETADLFFHALMVLGYHDITLQEILAELGRRFGKPGLRTANSGGAEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9L0</accession>
    <name>A0A1W1I9L0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3444"/>
    <dbReference type="EnsemblBacteria" id="SLM49611">
        <property type="protein sequence ID" value="SLM49611"/>
        <property type="gene ID" value="NSJP_3444"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3444"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012235638" evidence="1">
        <location>
            <begin position="26"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="397" mass="43851" checksum="72B11A1351CDF669" modified="2017-06-07" version="1">MHRLVKRVILWSTLLSLTLSNLVGAAEWSILPSIGTKAYYNSNLILTPFPHEATYGYWVSPAAEFAGKTERFEASGRVAADFVSYYGGEATQFTNIFLPLTLRYKTERDVFGFTGGYTRDNTLMGELLATGVVLRFTQRDLWSANPTWTRMLTEKLSLQTAFQFADASYEDGLRLGLVDYQLLGASAGLGYQLNEQNTLQVTGSYTNFHTTNSSSPFRAYFPGVTAEFTHSFTETLTANVYGGSRYVSSTTETATDSMKSRKTIWVFGASVTQAFEHASIKVKASRDVVPSGFGLLIQTDRIGVLASYDLTETVTASFDAAGYLVSGVTDTASGGAFPGQRYAQASPRLSWKFFDWWKLEASYTYGWRDVDTFTNTATSNAAMLTLTYFPPKLAMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Y5</accession>
    <name>A0A1W1I9Y5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative non-heme chloroperoxidase</fullName>
            <ecNumber evidence="2">1.11.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.10" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49834">
        <property type="protein sequence ID" value="SLM49834"/>
        <property type="gene ID" value="NSJP_3667"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3667"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016691">
        <property type="term" value="F:chloride peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="279" mass="29951" checksum="697DD4F251978FF2" modified="2017-06-07" version="1">MPYVTVGKENSGNIELYYEDHGSGKPVVLIHGYPLSGASWEKQVPRLLDAGYRVITYDRRGFGKSSQPTGGYNYDTFADDLHTLIRSLTLRDFSLVGFSMGGGEIARYFGNYGSDGASKAVIIGGIPPFLLKTADNPEGVDGGVFDGIKKAVAGDRYAFFSEFFKNFYNTDLLLGKRVSDEAVRASWNLAAGASATASVACVSTWIEDFRKDLAGLDVPTLVIHGDNDRIVPLAASGQRTAALVKGARLVVVKGGPHCITWTHAEEVTAELLNFLGGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA64</accession>
    <name>A0A1W1IA64_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxyacylglutathione hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49885">
        <property type="protein sequence ID" value="SLM49885"/>
        <property type="gene ID" value="NSJP_3718"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3718"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="26"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="244" mass="26701" checksum="6A7E7C79E9E8FD2D" modified="2017-06-07" version="1">MPERGTYVVTTLLDVNEVQNVDDRGESRTYLVADVASRKAIIIDSIIENVERDLTLVKELNLILAFAVETHIHADHITGASLIKDRTGVPIVYGGGAEAVVTGADLFLHDGKDLTFGATSIRALATPGHTDSCTSYWLPRGVFTGDTMFIRGNGRTDLQGGSSKKLFESVRAKLFTLPDETVVYPGHDYNGRVASTIGEEKRFNPRLNLSIDLDTFVDMMNKRRAPLPEKIDIAVPANMKAGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA95</accession>
    <name>A0A1W1IA95_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OmpA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3745"/>
    <dbReference type="EnsemblBacteria" id="SLM49912">
        <property type="protein sequence ID" value="SLM49912"/>
        <property type="gene ID" value="NSJP_3745"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3745"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="3">
        <location>
            <begin position="299"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="113"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="434" mass="48366" checksum="188B28FE25719297" modified="2017-06-07" version="1">MNGKLLVLCSVGFLVSTGCVSSGTHDQTLAELDQARKASEKTKADFDMFKKESSTKISALEADKSKLSNDLLESQGASAQLKRDLNETQTNLDSTLASRSALENDARKIRTETTGMERSNESLQRERNQLQVQLNNLQHDYNATSQELENKLKAEQDTVASLQRDKDLLIARATGISDELAKAQKHMGELETDAARAKDLDRQLSDLQKRTGDLEGQANRAKDLEQRLSQRDLEVGRLTQGGEALTAEKDALAAEKARLEKERAAKEEEIQRLTKTQEDLTKSLQSQIDKGDIKIKQVRDRLTINMVEKVLFNSGQAQVKPEGLKVLKQVADVLKDVHDKEIRIEGHTDNVRIGGKLKEKFPTNWELSTARATNVVRYFIEQGGVRAENFEAVGFADTRPVADNASEEGRTENRRIEIVLFPKDLSTIAGDIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAA7</accession>
    <name>A0A1W1IAA7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_3821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3821"/>
    <dbReference type="EnsemblBacteria" id="SLM49988">
        <property type="protein sequence ID" value="SLM49988"/>
        <property type="gene ID" value="NSJP_3821"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3821"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="38"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="283" mass="31693" checksum="00A52B8B496F04B1" modified="2017-06-07" version="1">MDASENMSLAAVPFRRIEPSRGWRALNIRELWQYGELLYFLAWRDIKIRYKQTALGAAWAVIQPVMTMAVFSLFFGKLANMPSDGIPYPLFAFTALVPWAYFANGLTESSNSLVSSSNLIKKVYFPRLVVPIAAVISGGVDFIIAFVVLLGMMLFYGMYPTVNVVWLPLLVLLTFVTALGIGLWLSALNVQYRDVRYTIPFLTQLWLFATPIAYPSSLLSEPWRTLFALNPMVGVVEGFRWALLGTTEAPSPMIAVSTLATLLLLVGGAFYFRRMEKTFADVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAF4</accession>
    <name>A0A1W1IAF4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Glycosyl transferase, family 2</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50004">
        <property type="protein sequence ID" value="SLM50004"/>
        <property type="gene ID" value="NSJP_3837"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3837"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="26"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="443" mass="49032" checksum="F3E7786617482B4E" modified="2017-06-07" version="1">MSHDRIPLAPATESRLREIDFADILVGIPSYNNAATVGHVVRAVAAGLAKYFPAKRAVLVNADGGSSDDTTAVVAQTAVDHRQLLIADRQSVLHRIVTPYHGIPGKGSAFRTIFEIARQLNARACAVVDADLRSISPEWIEMLLRPTVEGEFDYVAPFYLRHKYDGTITNSLAYPLTRALYGNRIRQPIGGEFGFSGALAAHYLDQHVWESEVARFGIDIWMTTEAIACGARVCQSFLGAKIHNPKDPASDLSDMLRQVVGSLFASMERHVTGWSAVVGSHPVPLFGFPYEVSVEPVHVDVDRMVSYFQQGLTDLAPLWREILSHATFEHLIDLNGQRGKDCRIPDELWSHIVFDAAAAYHHQVLPREHLLKCLTPLYLGRTASFVLATMGLTSVEAERAIEQLCATFEDRKPYLLERWEERPSRWTGTAGVDHDGAGVGRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAH8</accession>
    <name>A0A1W1IAH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50024">
        <property type="protein sequence ID" value="SLM50024"/>
        <property type="gene ID" value="NSJP_3857"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3857"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="73" mass="8180" checksum="EAC7EFD6A8BEF17C" modified="2017-06-07" version="1">MKWSRKPGEPIYQRRHMVALLVAVCLPIVLVQLYKVYIGPIGFFAQLTVAIVVSVFAGIGLYLLYNSSARNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAH9</accession>
    <name>A0A1W1IAH9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zot domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49921">
        <property type="protein sequence ID" value="SLM49921"/>
        <property type="gene ID" value="NSJP_3754"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3754"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008900">
        <property type="entry name" value="Zot_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05707">
        <property type="entry name" value="Zot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zot" evidence="2">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="383" mass="42014" checksum="6B3ADBB686E048FF" modified="2017-06-07" version="1">MIELLEGVPGAGKSYHAVAEYLLPWVRKGRRIYVNVDGFYLDRLAKFEGVPLEDLQRQITIWQTSAEVLDGLTKVDPGSAVFVDECQTVFRAQQKLNGEILRWLETHRHYGIDVLLICQDYRQVTSGVTRVIEMTTKFRRLDRFGFRNRYQAFVRGNPEELEVIRGFTGTYDPKVYAYYGSYATSTKEVRHVRSILRSPSIILGAIGLSVATGWFVFGGGTFGSGSTVSPTLATHTPKPPDWMRMDVSPRLSDIHPIRIQGGMTDPRLDGHEWLWVAEDGRLLTVDEIAAESGGTVQAITSRGGKVLKGSGVLWGGASTALSVLTDVPTAEVTSGASSLSAPTAPSVTKTPTRPASSIGERLTTERAATDPTSRAIGQIEEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAJ7</accession>
    <name>A0A1W1IAJ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50078">
        <property type="protein sequence ID" value="SLM50078"/>
        <property type="gene ID" value="NSJP_3911"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3911"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="71" mass="7579" checksum="E9307019B07FB31E" modified="2017-06-07" version="1">MSRPRATRQIWAMPVSLAWLTGVGLIAALLGDGIWDVVSWITLGTPIAVVLWCVGRSEARASSIADSSDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAL0</accession>
    <name>A0A1W1IAL0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3784"/>
    <dbReference type="EnsemblBacteria" id="SLM49951">
        <property type="protein sequence ID" value="SLM49951"/>
        <property type="gene ID" value="NSJP_3784"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3784"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="385" mass="42974" checksum="2519726E73077542" modified="2017-06-07" version="1">MANFLPFHVPDLGQEEINAVVEVIRSGWLTTGAKARQFENEFAAMVGARHAVAVNSCTASLHLALEAIGVREGDEVIVPTMTFAATAEVVTYFRAKPVLVDCTENTLNIDPKLIEEAITPRTKAILPVHFAGHPCEMDEIHAIAKAHGLYVIEDAAHALPAWYRGKMVGSLSDITCFSFYATKNITTGEGGMVVTNDAGVASRIRTMSLHGLSRDAWNRYTAHGSWYYEILSPGFKYNLTDMAAALGIAQLQKCERFWKSRDRIAAWYNEGLRDVPEVALPAAQAHVQHAWHLYAIQLDLGRLRIGRNDFIERLQQAQVGSSVHFIPLHLHPYYRDTYGYCASDFPTANAAFQRLVSLPLYSKMTEQDVRRVISTVRDIIQETRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAL6</accession>
    <name>A0A1W1IAL6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Multidrug efflux transporter, membrane fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3897"/>
    <dbReference type="EnsemblBacteria" id="SLM50064">
        <property type="protein sequence ID" value="SLM50064"/>
        <property type="gene ID" value="NSJP_3897"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3897"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="2">
        <location>
            <begin position="52"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="350" mass="37894" checksum="8911C263FB5351B1" modified="2017-06-07" version="1">MKGLSILLVVAAVAVVLVVRAWDRSTDESAVARETSSKSMLVEVVQAKVGAINESIQAVGTLQAIASITIRPEIPGIVRRIHFSDGQLVDRMAPLVELDQDELQAQANQAVAQERLAQLTYERLKRLSVQQTTIVPAQQVDEARMALQAAAANSLLFGTRLKKSVIKAPFAGTVGLRRVSVGDYVQPGQDLVNLEDLQTLHVDFKVPEVWLSRLSGNQAVGVMTDAFPGVTFQGKVTAIDPRVDSVNRTISVRAVVPNQDGRLRPGLFATVNVMLGQDARAVLIPEEAVFVQRDRSMVYRIQDGTARLAELVTGAHERGMVQVKEGLSAGDQIVRTGTHKLQDGMAVVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAM0</accession>
    <name>A0A1W1IAM0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Succinoglycan biosynthesis protein ExoA</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49961">
        <property type="protein sequence ID" value="SLM49961"/>
        <property type="gene ID" value="NSJP_3794"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3794"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="344" mass="37927" checksum="34AE40C0C2874734" modified="2017-06-07" version="1">MPLVSIIVPCRNESRYIELCIRSILAQDFPPTDFEVVVVDGMSDDGTREILARLAKPNTNLRVVDNPSRSTPCAFNIGIEAARGQHVAILGAHTEYAPTYVRTCTELLAAHPEACCVGGPIISKGRGLFGRAVAAVMAHPVGIGNAKHRYPNYEGYAEGACFPMFRKAVFDKIGLYDPSLIRNQDDELNYRVALHGEKVFISPKAQCTYFVRETPSELFRQYFQYGYWRVAVLRKHRLPSAFRQIVPPCFLLLSCITLVGGLLLPSWWRLTAAFLPFIYGGILTAVGVGLVRTSGWRIGLLVPVAASIIHTAYATGFTWAAVSSRRPVVSSPSHMKGECHASRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAW8</accession>
    <name>A0A1W1IAW8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol-3-phosphate acyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Acyl-PO4 G3P acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Acyl-phosphate--glycerol-3-phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">G3P acyltransferase</fullName>
            <shortName evidence="10">GPAT</shortName>
            <ecNumber evidence="10">2.3.1.275</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lysophosphatidic acid synthase</fullName>
            <shortName evidence="10">LPA synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">plsY</name>
        <name evidence="11" type="ORF">NSJP_3975</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:34075"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="2.3.1.275"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably interacts with PlsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PlsY family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.275" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3975"/>
    <dbReference type="EnsemblBacteria" id="SLM50142">
        <property type="protein sequence ID" value="SLM50142"/>
        <property type="gene ID" value="NSJP_3975"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3975"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01043">
        <property type="entry name" value="PlsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00023">
        <property type="entry name" value="TIGR00023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM50142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="203" mass="21641" checksum="FD9F01574ED5719B" modified="2017-06-07" version="1">MAEELLCALMAAFGYVLGAIPFGVVVSQALSLPDPRTVGSKNVGFTNVLRVSGAKAGILTLLGDLGKGWVMGWGAMQWLTVESYIMLVALSPIIGHMISPFLNFRGGKGVATALGSVLGLSPSMGLLLLLIWLGAVAIWRYSSGGALAAFGVFPVVAIVNEQRQEFLIFAIIVSVLIWIRHKDNIMRLWKGTESKIGEKKALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAY1</accession>
    <name>A0A1W1IAY1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4040"/>
    <dbReference type="EnsemblBacteria" id="SLM50207">
        <property type="protein sequence ID" value="SLM50207"/>
        <property type="gene ID" value="NSJP_4040"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4040"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="29"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="345" mass="38486" checksum="6F42DBEACF993E1B" modified="2017-06-07" version="1">MEPSTVTISAHKPQDSAPYLKSCEPALVSVVIPAYNCGNYIAETLESVIQQDYPKLEVLVVDDGSTDHTKEVVASVKSDRVRYVYQQNSGGPSGPRNTGVQQARGKYVAFLDSDDIMLPGKIQRAVDLLDREPHLGLVFANFVKFDESTGQHAGAFLDTYEYFKSAPKRLVGESQYVIQAAAAYDALIVENYIGTSGVVAPKAVLADVGPFDLRLRGPEDYDLWLRIAYAYDIGFIDMIGHRYRVRPDGITGLGDAKLVPHSIQVMQKQLDRPLPSSTRRNVRKKLAMQFFALGYCHQMAEEMKAARQHYLLSLKEANYWLSWKGLFMTFLGGGAIRRLKQLRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB33</accession>
    <name>A0A1W1IB33_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3942"/>
    <dbReference type="EnsemblBacteria" id="SLM50109">
        <property type="protein sequence ID" value="SLM50109"/>
        <property type="gene ID" value="NSJP_3942"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3942"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032623">
        <property type="entry name" value="FecR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16220">
        <property type="entry name" value="DUF4880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4880" evidence="2">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="1">
        <location>
            <begin position="137"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="349" mass="38584" checksum="8C9D452F44D19946" modified="2017-06-07" version="1">MVTLDSIVIGSRRILRRGDDVTPDDRTLSDEAIHWRVRLQADDVTEEERRACEAWKRQSPRHRAAFDKIDLLWGDLDEPSRLVWEDVRQGIEPVDAIVPRPTGTGWRRAAMAASILLMILAGLWFAGYQDAWDPGAITTARGERTSVTLEDGSIVHLNTNTAISVRLTGQRRYIHLKKGEASFMVAHDRTRPFEVESVSGITRAVGTEFNVRRQDQGVTVTVMEGTVEVSQPNSLAGADRGVASSVVTVGEQVRYSTSGGIGAVSQADMVQATGWRRGQLVFDLKPLGEVVEEVDRYWKGKIIVLNSDLRQHLISGVFKTGDPAAVVHALETTFHVKSVTVAGYLVLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB65</accession>
    <name>A0A1W1IB65_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate starvation-inducible protein PsiF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">psiF</name>
        <name evidence="2" type="ORF">NSJP_4111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4111"/>
    <dbReference type="EnsemblBacteria" id="SLM50278">
        <property type="protein sequence ID" value="SLM50278"/>
        <property type="gene ID" value="NSJP_4111"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4111"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011690">
        <property type="entry name" value="P_starv_induced_PsiF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07769">
        <property type="entry name" value="PsiF_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012777291" evidence="1">
        <location>
            <begin position="25"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="104" mass="10711" checksum="135810CAD1CFD505" modified="2017-06-07" version="1">MKITGLIALSCFVAALGFAPAAGAASAQQNKMKACNTAADEKGLSGEGKGEARQAFMKECLSAKSGTGGKTAQQEKMKTCNKEAGEKKLAGEERKQFMSGCLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB75</accession>
    <name>A0A1W1IB75_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">gatC</name>
        <name evidence="2" type="ORF">NSJP_4089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4089"/>
    <dbReference type="EnsemblBacteria" id="SLM50256">
        <property type="protein sequence ID" value="SLM50256"/>
        <property type="gene ID" value="NSJP_4089"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4089"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="PTHR15004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="95" mass="10600" checksum="61E9E98AEF3DA20C" modified="2017-06-07" version="1">MEITKQEVEKVAKLARLAISPSEREAFARQLSQILTHVETLNRYDTAGVEPTTTVLEQANVFREDVVRPSLPADLALANAPEREADGFRVPKIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZV1</accession>
    <name>A0A1W1HZV1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46247">
        <property type="protein sequence ID" value="SLM46247"/>
        <property type="gene ID" value="NSJP_0075"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0075"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="236" mass="26004" checksum="20836B084EAABE6F" modified="2017-06-07" version="1">MAPQPDRSLQDRGAERGAVLALLPMAATAAFYGLPTRLQDQPAVQFIPQLLGYLACMLWAARNPGLIARFGLEPAKIGAGLVRGVPVGCVLGFFNSFVILWCVPRLGYDLTFLTHTPHARLPVYLMLPWFICLIALFVEFNFRGFLLGRLQALGTAALGAGRPRLRSNLAIGLSALAFSFDPFMTQTFRELHWIAVWDGAIWGALHVAMRNLYVPITAHAVEVLVMYSVIRLALLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZY1</accession>
    <name>A0A1W1HZY1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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    </dbReference>
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    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SLM46282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="375" mass="41903" checksum="AA4B618152965970" modified="2017-06-07" version="1">MIVTVSTKTMERVTGKLTDQPLLFQYTIKLVLLVSFLELILYRLVSRLGMHLSKLAADHQWIIPTFTALTEIGQWLLNAVAILLFLGLVLGLTNRLASRGWGGLNIVTVPCVALLLLLTVGFLFVPPTMIGSAIYNLTALTAIVLLMTEYLMTHHDWSHRVLGVVYLLGISGWLYYQMVSTFFSFLGTVIAPPFVYEFHRGGEALMVLASILVYGAYGRGLSFRSRNQHQRRRAIWFWGTAGTIFTVLLFLDYLLSRYDPVMASNIRKGADGIGWIFQFGMGYTFYLPFALYMAGLLCWSYTVIRLLTMGRLAGYGLGLMFIAGYALLYSNLTLMVVLGVMLLTMDRYRREPLEAPSAVGAPMLSGSDRLAGDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I004</accession>
    <name>A0A1W1I004_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
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            <taxon>Nitrospiraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="NSJP_0142"/>
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    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007352">
        <property type="entry name" value="DUF420"/>
    </dbReference>
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        <property type="entry name" value="PTHR37692"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DUF420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="237" mass="26495" checksum="69AE72C98B61AECF" modified="2017-06-07" version="1">MDWLKDPGFLGTHATIGADLSQLMATLFTGLFVIGWFQAKKRQADAHHWLMLGGMIAMLSFFIAYYLFRQLGVLAVEGKEGFGGSQALYDNVFIPVLILHIILVIIGLVMAIYMIILGFRAQMFIGNRRQLSETPLVTTWKRIGMIMGGTTAVAVLAFALRGATAGFSMRKFEVYLGFLILVAFVLGIETTIQRIWPNGARRHRALGRFTMIIYCILFVTGSFTYTMLYILYPGKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I022</accession>
    <name>A0A1W1I022_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Outer membrane chaperone Skp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_0021</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Skp family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0021"/>
    <dbReference type="EnsemblBacteria" id="SLM46193">
        <property type="protein sequence ID" value="SLM46193"/>
        <property type="gene ID" value="NSJP_0021"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0021"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
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        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR35089"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="184" mass="20608" checksum="BD0851A4FD5E6BDC" modified="2017-06-07" version="1">MSWNPPHTNGLWHAAVLGLMLCIGISAGCASTKIEGRIGLVDPTRLLNDSNAGKKAKDTLTTFSKSRQALIEMDEKELRRMEEDFVKQASVLSPAAKGEREQVFRRRMAEYQQKAGELNREVQEKQKDVLDGFRDKVEIVVGKVAKRHGLQVVIDKGKGGPAIYGEPELDITNEVIEEFNREYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I041</accession>
    <name>A0A1W1I041_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative TPR repeat containing exported protein periplasmic protein contains a protein prenylyltransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_0182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0182"/>
    <dbReference type="EnsemblBacteria" id="SLM46354">
        <property type="protein sequence ID" value="SLM46354"/>
        <property type="gene ID" value="NSJP_0182"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0182"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02066">
        <property type="entry name" value="CpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039565">
        <property type="entry name" value="BamD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034706">
        <property type="entry name" value="CpoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014162">
        <property type="entry name" value="CpoB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13525">
        <property type="entry name" value="YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02795">
        <property type="entry name" value="tol_pal_ybgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YfiO" evidence="4">
        <location>
            <begin position="391"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="429"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="466"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="306"/>
            <end position="393"/>
        </location>
    </feature>
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        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="516" mass="57710" checksum="DE6D717DA474025F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0D3</accession>
    <name>A0A1W1I0D3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV pilin PilA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pilA</name>
        <name evidence="2" type="ORF">NSJP_0260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0260"/>
    <dbReference type="EnsemblBacteria" id="SLM46432">
        <property type="protein sequence ID" value="SLM46432"/>
        <property type="gene ID" value="NSJP_0260"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0260"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="173" mass="18187" checksum="D2228EBB0174B054" modified="2017-06-07" version="1">MCKQLKSHKGFTLIELMIVVAIIGILAAIAIPNFIAYQAKSKQSEAKVSLGAIFTSAVAYQAESQNPQSYAPATISQIGWQPSGTPRYRFFYMDGVNTTTGVGTTINFFPGSSSAASPCNVTAPPASGGFVVASNTSGFTAGANGNIDGDVACDHWFINDVRNLQNPNNDVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0K4</accession>
    <name>A0A1W1I0K4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional regulatory protein ZraR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">zraR</name>
        <name evidence="9" type="ORF">NSJP_0211</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0211"/>
    <dbReference type="EnsemblBacteria" id="SLM46383">
        <property type="protein sequence ID" value="SLM46383"/>
        <property type="gene ID" value="NSJP_0211"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0211"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="143"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="455" mass="51195" checksum="26394DB8120774BC" modified="2017-06-07" version="1">MKARILIVDDDPDIATMLEDRLQASDYGTLVAQDGVQALELIEQEVPKLMLLDLDMPRLTGLEVLKRLPKIRAAEDLPVIVMTAHGSIEAAVEAMKSGAYDFLTKPLDKDHLLLVIQKALERDALKRQVACLKSEIDGRYTSIIGTSPNIRSVMEAAQRAAKSDAGVLLLGESGTGKELFARSIHQWSPRRVNPMIVINCVALTETLLENELFGHERGAFTGADRLQKGKLEMADGGTVFLDEIGDMPMALQAKLLRVLQDREFHRVGGTRLVSVNIRIIAATNKDLKQAVKNGHFREDLYFRLNVITLTLPPLRDRPDDLPLLAKFFLNRHAKEAKRYGMMFHPEAMNVMMQYTWPGNIRELDNVIARAVILSPTEIIEPDLLVMDAAALSHPEALTYVSLPYHRSMEEHSRHIIDQALKQAEGNQTKAAERLRLQRTYLARLIKQQKLRQEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0L6</accession>
    <name>A0A1W1I0L6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AcrB/AcrD/AcrF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46540">
        <property type="protein sequence ID" value="SLM46540"/>
        <property type="gene ID" value="NSJP_0368"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0368"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="563" mass="61991" checksum="0FADE3E6CD812736" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0L7</accession>
    <name>A0A1W1I0L7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46531">
        <property type="protein sequence ID" value="SLM46531"/>
        <property type="gene ID" value="NSJP_0359"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0359"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012144911" evidence="1">
        <location>
            <begin position="33"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="518" mass="56030" checksum="3131556CB5D2EBEA" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0P6</accession>
    <name>A0A1W1I0P6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Replication-associated recombination protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rarA</name>
        <name evidence="4" type="ORF">NSJP_0403</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0403"/>
    <dbReference type="EnsemblBacteria" id="SLM46575">
        <property type="protein sequence ID" value="SLM46575"/>
        <property type="gene ID" value="NSJP_0403"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0403"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="59"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="431" mass="47486" checksum="877C655A5468CA1F" modified="2017-06-07" version="1">MPRDTHDRLDLFAEPSPEKSAGTSPLAERLRPRSFEDLAGQEAVVGPDRPLRKAIESDRLASLIFWGPPGCGKTTLASLIARHTKAQFVSFSAVTGGIPELREIIKTAEHRLATSGRRTVLFVDEIHRFNKAQQDAFLPHVERGTIILVGATTENPSFEVIAPLLSRSLVVTLQPLTEEALERILNRALHDVEAGLGATRLELTDEAKRRLLNYANGDARSLLTALEFVAGQVSSNETDVRRVDDPAMEAALLTKTLRYDKAGEEHYNLISAYIKSLRDSDPDGALYWLARMLEAGEDPKFIARRLVIFASEDVGNADPTGLLVATAVAQAVQFVGLPEAQINLAQGTTYLATRTKDNASYVGLLEAMNDAKSFGNLGVPLHLRNAVTSLMRDQGYGKGYRYVHDDPKAAESQTHLPEPLRGRRYFRPKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0R8</accession>
    <name>A0A1W1I0R8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46598">
        <property type="protein sequence ID" value="SLM46598"/>
        <property type="gene ID" value="NSJP_0426"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0426"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="416" mass="45056" checksum="CD1E3B1540068B6C" modified="2017-06-07" version="1">MGCRKIGGCHGVPLHYTLYLEMFAERERLPLIGRAQADAVQAARHVEHAIIDDLEEGLAVVNQERDIVGPHLQHHLRAGDLAVRPVSESRIEETRVMGAQFSASRLVGHHFCRIVRRNADAFFGSQNVELFRLQQQAVLAMPVQGLPEIRCRVIADFGKVDDVAVLFRPVADDGVAGSLLSLEIDAKEQTVIGTEFLGRHGLAFGRVVIEQRLLPVQALERRVGGGGLAADETDLVEALAGLHLDRERTGYDLEKQGAVIAGTDLVESGVEIGDDAREHVEPAGGALRVGPRPQRLRQLEGFQQRHEVNMAFLEDRATAQVHFVHHEVGVIKVHHVEPAGNGRQLGQKAADQPIGFLAEAEVEAGRLDLPVFDRNGGGDASSGDQSGDLLIGQDALSRSGSHQSSMSPPQLLPQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0V3</accession>
    <name>A0A1W1I0V3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_0440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0440"/>
    <dbReference type="EnsemblBacteria" id="SLM46612">
        <property type="protein sequence ID" value="SLM46612"/>
        <property type="gene ID" value="NSJP_0440"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0440"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="357" mass="39273" checksum="E30F6C66C73243C5" modified="2017-06-07" version="1">MTRPHPFTVVFFGLLLVLLYQIGLILQPFLFPALWAALLVHATYPLHERLTRAFGGRDTLSASILTIGVLAVVVVPLIVVGILLVHETRDAEKAVRSWIAEGGLDRLPEQVAAVPIVGEWLRTLITGKNLQEISVEQSVITGAKFLSQFFVDQMGGLLKNTLLLVSDFFIMLMVLFFFYKEGREWTHVLNDLIPLDRSHKEKILTRLDQTVRAVVKGMLVTAVVQGLLAGLAYLVLGVPFPVVLTALTIILAPIPFGGTALVWGPVVAYLFWAGTMWKAVAMLAWGLGVVSTVDQVLRPWLIGKDVEIPVLFLVFSVLGGLALYGLIGLFIGPVLVSLFITALQIYREEYQQTVPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0W0</accession>
    <name>A0A1W1I0W0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46509">
        <property type="protein sequence ID" value="SLM46509"/>
        <property type="gene ID" value="NSJP_0337"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0337"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="86" mass="10017" checksum="B7387C7F81FA2B54" modified="2017-06-07" version="1">MRMSVRDRERESRDGNRWRHWRQLPLSTGLISPFFLGETSTPISILCKTLPTLTGRCAGFIIRQIRLELFPTSRYHPRPSALLIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0W8</accession>
    <name>A0A1W1I0W8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome c551 peroxidase</fullName>
            <ecNumber evidence="11">1.11.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ccpA</name>
        <name evidence="11" type="ORF">NSJP_0347</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="6">Binds 2 heme groups.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Binds 2 heme groups per subunit.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.5" evidence="11"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46519">
        <property type="protein sequence ID" value="SLM46519"/>
        <property type="gene ID" value="NSJP_0347"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0347"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004852">
        <property type="entry name" value="Di-haem_cyt_c_peroxidsae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026259">
        <property type="entry name" value="MauG/Cytc_peroxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03150">
        <property type="entry name" value="CCP_MauG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000294">
        <property type="entry name" value="Cytochrome-c_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013003667" evidence="9">
        <location>
            <begin position="26"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="10">
        <location>
            <begin position="220"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="6">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="6">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000294-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM46519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="358" mass="39579" checksum="3FA1F5633D88D368" modified="2017-06-07" version="1">MKQRSLVKVGMAVAVGASLSIFTWAMIGQAETAKDAAKSAEVVKLPQLLGLEDPNSYVPKDNPLTAAKVELGRTLFFDNRLSKNNTVACVSCHLPGKGFTDGKPVSTGVFNLKGGRSAPAAFNRVFAEAQFWDGRAATLEEQSIGPFTNPVEHGFANYDDMLVKMKKLAGYRKMFKDVFGTDVTMDGVAKAIASFQRTILSGNSPADRFDYGGEEGAISEEAKRGLELFRGKARCVRCHSNFNFSDEKFHNLGIGWDNNTVDLGRYMVTKNPEDIGAFKTPTLREIARTAPYMHDGRFKTLEEVVEFYNQGGIENPHRDNTIIPLELTDQEKKDVVVFLRSLNGEGWQHVKAPKVFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0W9</accession>
    <name>A0A1W1I0W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_0455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0455"/>
    <dbReference type="EnsemblBacteria" id="SLM46627">
        <property type="protein sequence ID" value="SLM46627"/>
        <property type="gene ID" value="NSJP_0455"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0455"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="10"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="538" mass="57734" checksum="42A050686DD602E4" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I165</accession>
    <name>A0A1W1I165_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0552"/>
    <dbReference type="EnsemblBacteria" id="SLM46724">
        <property type="protein sequence ID" value="SLM46724"/>
        <property type="gene ID" value="NSJP_0552"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0552"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="273" mass="29514" checksum="E7FBA2859CB32F7F" modified="2017-06-07" version="1">MTHPAAILIESHDGVTRVTLNRPHRRNAFDAGMVEALSRVFDESGRNPSVRAVVLTGNGPAFCAGADIDWMRSGGTRSAPERRKDAEELMRMFRAIDECPCPVIARVQGPAFGGGVGMIAACDIAVAVEDATFALSEVRLGMVPSVIAPVLLRKTGESFLRRCCLTGEPFSASAAKQGNLIHDVVEKTQLDARVDELIQSVLRAAPQAAQDTKALLHRLPALSGNEQWNTCVESNVRARLSDEAQEGFRAFLERRAPVWTAMPGKRGSRSAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1A5</accession>
    <name>A0A1W1I1A5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46649">
        <property type="protein sequence ID" value="SLM46649"/>
        <property type="gene ID" value="NSJP_0477"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0477"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="42" mass="4593" checksum="C81974DFC0920D6E" modified="2017-06-07" version="1">MNGGYTQKDLKPLLTVGSGRRRAIPKVLGKGMEPFLSVLLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1D6</accession>
    <name>A0A1W1I1D6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46818">
        <property type="protein sequence ID" value="SLM46818"/>
        <property type="gene ID" value="NSJP_0646"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0646"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="437" mass="48525" checksum="AA6C6DC630BF5F21" modified="2017-06-07" version="1">MRTLLQTLSQYAAARRLAWALVCGLLVACSAPKERESLSPPSPGPLGWEVPPLFSAAGILTPAWLKGPHHSVQDEVVNDGVQYHFVVNSEFGAFPAAGVPMLRTRVIETQAIAELNETRQSEVFVDALKFQLLHPLQGVKILLTEPKRLGSSVGGGVLEFLAMPGQASKFEGSEQEDSMTKSAIGFSYLKRKLAFQFGVDPYSSNRRLQDELNELTWVAFTADLAPQIGYVFMPAPAILWMSFSATRWTSYLDEQVRDHSPGDLRAMDRAKLLAMGISEEDIHRFFLNGHFSPRHATIITAGLDALTGVDNREAFLAVAEEAPSEELVLFYQHLVEMMRGYHVHVGAVDRLLVLPRVPALYTKNKTLVVMLPLDYVFWTPRVASVAQALTTHVPSRPRIARRELWIAGNASPRARQELESLGWTVYEQVSAKLNPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1J3</accession>
    <name>A0A1W1I1J3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0682"/>
    <dbReference type="EnsemblBacteria" id="SLM46854">
        <property type="protein sequence ID" value="SLM46854"/>
        <property type="gene ID" value="NSJP_0682"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0682"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="169" mass="18827" checksum="E24E9858C8152B3F" modified="2017-06-07" version="1">METGRKGIVLVGHGGIPKDCPQELVAKLKRLEGQRRAAKLPPSQEEIDLDQRIRRWQRTAESDPYQSGLTAVAEALSPQLDGALFAIAYNEFCAPTLEEAVDDLVGKGATQITVLTTMFTPGGSHSEVEIPEILEHLRPRFPGVELRYAWPFDLQLVAKTLAEQLRRWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1J6</accession>
    <name>A0A1W1I1J6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="9">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">gltX</name>
        <name evidence="13" type="ORF">NSJP_0567</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0567"/>
    <dbReference type="EnsemblBacteria" id="SLM46739">
        <property type="protein sequence ID" value="SLM46739"/>
        <property type="gene ID" value="NSJP_0567"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0567"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020752">
        <property type="entry name" value="Glu-tRNA-synth_I_codon-bd_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="11">
        <location>
            <begin position="3"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="12">
        <location>
            <begin position="332"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="237"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM46739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="471" mass="53445" checksum="03FD3DC5F70FBA88" modified="2017-06-07" version="1">MTQVRVRFAPSPTGFLHIGGVRTALFNWLFARQQHGVFVLRIEDTDQDRSTEESIAAIIEGMKWVGLDWDEGPFRQTERMDLYRQHAVRLFDQGKAYWCVCKPEELETRRREAEAKGLSPRYDGRCRNLGITQPSGEAALRFKAPQDGQTVVDDLIKGKVVFDNSVLDDLIILRSNGYPTYNFSVVIDDALMQITHVVRGDDHLTNTPRQVPIFEALGFPIPRFGHLPMILGSDKARLSKRHGATSIMAYRDMGYLPDAMVNYLVRLGWSHGDQEVFTRQELIEKFSWDHVQKSAAVFSPDKLQWLNAEYIRTSPPEQVADALIPLLESAGLTEQVQRVSRTWLAELVVLVKERVKTLADMVTWVTPYFGETVSFDEDAAKKFLTPAVAPLLAKLLARFEAFPTFSKPEWEDTLKKLVEEEGWKMGQLAQPVRVALTGRTASPGLFEVMDVLGRDRTLLRLRKGLEKAQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1M9</accession>
    <name>A0A1W1I1M9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46733">
        <property type="protein sequence ID" value="SLM46733"/>
        <property type="gene ID" value="NSJP_0561"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0561"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="100" mass="11025" checksum="6B35E99137AB2C00" modified="2017-06-07" version="1">MSFVYFPSGWDETIRPPGVLLASGAGLFTLVFEQVRKHLRIQDMNIKGAALNQLWGLCYSCASSRCRPPWSHRLAWPRTEPSQGSDTGSNPVGTTIPTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1U5</accession>
    <name>A0A1W1I1U5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rkpK</name>
        <name evidence="12" type="ORF">NSJP_0779</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0779"/>
    <dbReference type="EnsemblBacteria" id="SLM46951">
        <property type="protein sequence ID" value="SLM46951"/>
        <property type="gene ID" value="NSJP_0779"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0779"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="316"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="152"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="252"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM46951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="444" mass="47746" checksum="B5F8CA865610DDC4" modified="2017-06-07" version="1">MQISVIGTGYVGLVSGACFAEFGVNVLCMDTDAKRIARLEKGDVPFYEPGITELVAKGISQSRLSFTTDLTRAVDHGQVIFIAVGTPPKKDGSADLSYVEEVGRGIARTMTSYKVIVTKSTVPVGTGELLKKVISANQPKKVLFDVASNPEFLREGSAIEDFMRPNRVVIGSESEQAASIMKDLYRPLYLLETPFVVTDVPTAEMIKYASNAFLATKISFINEIATLCERVGADVQMVSKGMGLDHRIGSKFLHAGPGFGGSCFPKDLAALVQMGDRAGYPMQIAQAAATVNSQQRDRMIDKISAVLGTIKGSTIAMLGLSFKPNTNDLREAPALAIAQALMQSGAGLRGYDPAALEEAAQILPGMIACKDPYDAATGADALVLMTEWNEFRNLDFAKLKTIMRKPVLVDLRNVYESSRVTSLGFHHVSVGRAPQDPVVRAKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1W1</accession>
    <name>A0A1W1I1W1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0828"/>
    <dbReference type="EnsemblBacteria" id="SLM47000">
        <property type="protein sequence ID" value="SLM47000"/>
        <property type="gene ID" value="NSJP_0828"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0828"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025113">
        <property type="entry name" value="TRL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13146">
        <property type="entry name" value="TRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012551609" evidence="1">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="109" mass="11016" checksum="7F48A9E4D9188954" modified="2017-06-07" version="1">MKKKAYVLLSAAFVTAFGLSLAGCMPVASPVTGIIFTEVKYGFMATTATAATKEGKACAQTILGWVATGDASLTAAKAAGGITTVSHVDHTAKNILGIVADYCTIVKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Y5</accession>
    <name>A0A1W1I1Y5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Peptidase, family M48</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_0833</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0833"/>
    <dbReference type="EnsemblBacteria" id="SLM47005">
        <property type="protein sequence ID" value="SLM47005"/>
        <property type="gene ID" value="NSJP_0833"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0833"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="180"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="375" mass="41193" checksum="9E2A06DBD2866117" modified="2017-06-07" version="1">MNPNALCFGSDYPATGLPCRVEVISIGIAVRFEDRSTDAQDDADTVPFDRLSLSAGGLNHDQLIIRYGSEADARVLYLNDPAVIHALRAAAPTAVTENLEATATAVRRKRHRRRISWFAASVLAVSLGTAVWFGSDLAVNLAVARIPVEWEQKLGEAAYQDFLGRQTVVKEGPAVDAVREMTRRLTDQISDDPYRFEVTVVRSDVVNAFALPGGYVVVFTGLLQKAESGEEVAGVLSHEFNHVLQRHGLERVVKQIGLTAVLSILLGDQQGLIGLTRQISGELLTLKFGRAQETEADVTGLRLLRKAKIDSNGLVRFFERMAEQQGDPIEMLSTHPMSAARVERLKAEMATLPKQTVEPFTFDWKQVQGSLSVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Z7</accession>
    <name>A0A1W1I1Z7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47014">
        <property type="protein sequence ID" value="SLM47014"/>
        <property type="gene ID" value="NSJP_0842"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0842"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="22"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="140" mass="15593" checksum="D5B156AE473C7511" modified="2017-06-07" version="1">MSTRSRSSESTVHLKKTHALLDRRDAERAPLNYRVTYTTDNGSQVASGEGIVRELSKTGCKILSTDPLSVGVRLTLFLDFQDGKSPLCLVGAKVCWVEGNHFGVKFPTATPEERQRLQHVILKHLTRSGSPQQRTAFRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2A2</accession>
    <name>A0A1W1I2A2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_0953</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47125">
        <property type="protein sequence ID" value="SLM47125"/>
        <property type="gene ID" value="NSJP_0953"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0953"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="281" mass="31263" checksum="654632DC56C4D58B" modified="2017-06-07" version="1">MNQFDWIRFDSSVSWDGLTSLVLLVSLLIIRALVVRGISRNAGLSMEAKRRWVVTTRNSILFAFLIGLAVIWAHELQAFAVSLVALAAALVLATKELLLCWSGSALRVGGKVYSVGDRIQIAGHRGVVLDHDMFTTKLLEIGPGQASHLYTGRVTVFPNSLLFTNALVKENPGQEYGLYTLAVPLQSDEHWQEKEKRLLESAKAECAPFMAEASRQMKLLEQTNLLEAPSPEPRVTIQLVDSGRIHLILRFPAPDRGRSRIEQAILRRFLMPAASFQQHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2U6</accession>
    <name>A0A1W1I2U6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47327">
        <property type="protein sequence ID" value="SLM47327"/>
        <property type="gene ID" value="NSJP_1155"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1155"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="131" mass="13760" checksum="404BF2BB340071A0" modified="2017-06-07" version="1">MVRAMSMWVAVTLVVGGSFLSLEPVGQAEPADAGLHLVAGTLSKLDLPNGRGVLTTDLGRPIYFDVPNAYLFENVTVGARIAIRLDRYAHAIRVMDTSVADVVPPEGSTPEQSSADTFSSDSTDTGGTNPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2W3</accession>
    <name>A0A1W1I2W3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1184"/>
    <dbReference type="EnsemblBacteria" id="SLM47356">
        <property type="protein sequence ID" value="SLM47356"/>
        <property type="gene ID" value="NSJP_1184"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1184"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046027">
        <property type="entry name" value="DUF5985"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19447">
        <property type="entry name" value="DUF5985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="86" mass="9802" checksum="712E504F47BFA61B" modified="2017-06-07" version="1">MGMMIYGLCALTSFLCAWLLLQAYARTAYKLLLWTGMFFVVSTVNNLLLMIDKIVFPVTIDLSIPRYLIAFLALGVLFRGLIFEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I308</accession>
    <name>A0A1W1I308_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Histidine kinase with N-terminal NAD-binding region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1218"/>
    <dbReference type="EnsemblBacteria" id="SLM47390">
        <property type="protein sequence ID" value="SLM47390"/>
        <property type="gene ID" value="NSJP_1218"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1218"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="165"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="370" mass="41142" checksum="11511477E1CB7E87" modified="2017-06-07" version="1">MPMAQAKSSHVRRKSGSMPGSTHVAIIGAGRGGTALMEIFANDPLVEIVAVAETNSAAPGLGLAKRLKIPITRDYRLLLNLDRVDLIIDVSGSPEVWKVLQDFHRMGVTILGGASAKFMWELIEARIRATGEIEKTLNKYQSLYRLYVKETGAAVTEERTRIACEIHDGLVQSLAGVNFKLELSQQLLRKNPKASLATLRESKQQLKLAIQEARQVIFNLRPLQYDKMELIPGLTNYLKSYQTQSRVKTEFTVSGDEQILFPRTKIFLFRIVQEALSNVAQHAKASRVSVRLEIDFDKLTVTIADNGVGFDMEQVLHNPEKWDHFGIRGIVERARLVGGEATIQSKKGRGTTIVVEVPLGKKETPDDGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I312</accession>
    <name>A0A1W1I312_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1041"/>
    <dbReference type="EnsemblBacteria" id="SLM47213">
        <property type="protein sequence ID" value="SLM47213"/>
        <property type="gene ID" value="NSJP_1041"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1041"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="200" mass="22432" checksum="A0D1CF6585389660" modified="2017-06-07" version="1">MEKPAESQYPIHDLLRRRWSPRAFSERSLEAETVRSLFEAARWAPSSNNEQPWRFLAASLEAGADYGRLLACLNEGNRKWAFRAPLLILSVAGLRFEDGDTLNRHAFHDTGLAAENLVLQAVALGLAAHQMAGFDVEKARTSCLIPPGYEPVAMIAVGYPGDPAILPEYLREREMKVRERKPIGEFVFSSRWGLVSPLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I322</accession>
    <name>A0A1W1I322_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1051"/>
    <dbReference type="EnsemblBacteria" id="SLM47223">
        <property type="protein sequence ID" value="SLM47223"/>
        <property type="gene ID" value="NSJP_1051"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1051"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012686950" description="FGE-sulfatase domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="3">
        <location>
            <begin position="150"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="377" mass="39902" checksum="945C32FC9FBFB51F" modified="2017-06-07" version="1">MRMTAAVMLTAVLSIALVATPAQADEAAAPKSEGAQTPAPAPTPPKPKPPEGDAKPPAVKPAAPAETNGNGKDAAPAKPEAAPAKPEASPAPAPSPAPTSPPPVKPKASEGESKPPAKSAPAANGSTPSASKPSPTPPLPAEITGKDGAPMVLIPAGEFAMGTDKGDDDEQPIHRVFIDSFYIDKFEVTNGRFAKFVEAIQIEPPWGFKDKETPVVHIDRPVRWVNWMDAMGYCLWAGKRLPTEAEWEKAARGTDGRLYPWGNDAPTPAHAVFGLKEGADTVSAIGNRDKGKSPYGVHDMAGNLYEWTIDWYDEQFYSKNPAINPRGPAEGAAKVQRGGSYTNAPYRLRSTFRTKGDPTEHDPNVGFRCAQDVPAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I343</accession>
    <name>A0A1W1I343_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1255"/>
    <dbReference type="EnsemblBacteria" id="SLM47427">
        <property type="protein sequence ID" value="SLM47427"/>
        <property type="gene ID" value="NSJP_1255"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1255"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="595" mass="65339" checksum="8C8F6AF357A55068" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I365</accession>
    <name>A0A1W1I365_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47448">
        <property type="protein sequence ID" value="SLM47448"/>
        <property type="gene ID" value="NSJP_1276"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1276"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="62" mass="6754" checksum="E8925D006DB64E6E" modified="2017-06-07" version="1">MDTSPEALTGRSTLSACGGRSEWIIGADSLRDIRECRTGCWYHLYLNSGSAHPRQGLTGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3A7</accession>
    <name>A0A1W1I3A7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1722 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1283"/>
    <dbReference type="EnsemblBacteria" id="SLM47455">
        <property type="protein sequence ID" value="SLM47455"/>
        <property type="gene ID" value="NSJP_1283"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1283"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007553">
        <property type="entry name" value="2-thiour_desulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013560">
        <property type="entry name" value="DUF1722"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017087">
        <property type="entry name" value="UCP037004"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04463">
        <property type="entry name" value="2-thiour_desulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08349">
        <property type="entry name" value="DUF1722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037004">
        <property type="entry name" value="UCP037004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1722" evidence="1">
        <location>
            <begin position="192"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="317" mass="36323" checksum="2B4EF75E13188E22" modified="2017-06-07" version="1">MTAHPIRLGISRCLLGDQVRYDGGHKRDHFLTEVLSRHVEWVPVCPEVEAGFGTPREAMRLEGGPRSLTLMTVESRRNMTEPMMLFVQRKVDALEEADLSGYVFKKESPSCGMDGVRVFDRRGRAGRSGAGLFTRAFRERFPLVPIEDEERLSDGMIREHFIERVFCYHRWRALSLDAPTRQAVVRFHTIHKYLLMAHAAAPYRALGRLVAQAHRYRPMDLVGQYGLLFMKALAEMTTKRKQANVFHHLVGHLKGRLKSHERAELDAAIHDYHQGAVPLIVPLTLVKYFVAKYEIEYVGAQTFLNPYPEELMVSHGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3K4</accession>
    <name>A0A1W1I3K4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 13">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">yidC</name>
        <name evidence="16" type="ORF">NSJP_1408</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1408"/>
    <dbReference type="EnsemblBacteria" id="SLM47580">
        <property type="protein sequence ID" value="SLM47580"/>
        <property type="gene ID" value="NSJP_1408"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1408"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01810">
        <property type="entry name" value="YidC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019998">
        <property type="entry name" value="Membr_insert_YidC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028053">
        <property type="entry name" value="Membr_insert_YidC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038210">
        <property type="entry name" value="YidC_periplasmic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038221">
        <property type="entry name" value="YidC_periplasmic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14849">
        <property type="entry name" value="YidC_periplas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00701">
        <property type="entry name" value="60KDINNERMP"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01900">
        <property type="entry name" value="YIDCPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03593">
        <property type="entry name" value="yidC_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="YidC_periplas" evidence="15">
        <location>
            <begin position="82"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SLM47580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="549" mass="61027" checksum="B294BE330F61D59F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3P1</accession>
    <name>A0A1W1I3P1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1465"/>
    <dbReference type="EnsemblBacteria" id="SLM47637">
        <property type="protein sequence ID" value="SLM47637"/>
        <property type="gene ID" value="NSJP_1465"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1465"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="PTHR23264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="306" mass="33444" checksum="39A9A43CE82565C5" modified="2017-06-07" version="1">MAPDKDLKTILGKLRYSDDAKVVQQITEQMQQVQARMTGIKHKLVVMSGKGGVGKSMTTVNLALALARQHSRVGLLDVDLNGPCVPRMLGLHGRSLTMTPEGALPPVGPLNIKVASMDFFLGAASPVRWKGPMDVSPVWLGLMEMNVIREFLADVVWGELDYLLADLPPGAAADKPPVIAGFIPDLAGAIVVTTPSEVASDVVQKSVTYARDMGIKVLGIVENMSEYRCPSCGEQNELFEGNTEAMCEVLDLPLLGRIPFDRKLARTFDKGEPLLDETYPTIQRYQEIAGRIRTLLDYKKVLAEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3W8</accession>
    <name>A0A1W1I3W8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47694">
        <property type="protein sequence ID" value="SLM47694"/>
        <property type="gene ID" value="NSJP_1522"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1522"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="158" mass="17613" checksum="D175939765FAF20D" modified="2017-06-07" version="1">MTPNEAAAALIAALPKTVTPSNLEEYGIEATTERAQQISCELLCLNLFWISAAVAAHIPKKYQPLVGELVLQAVGSWWTPTPPLGPITWELFLAEWEDRSRRYDQVLQESGNTLAVHTEATEYLEEQRIVSQDERGKLLAFFLDSVPVDGYGQVLQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I423</accession>
    <name>A0A1W1I423_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47752">
        <property type="protein sequence ID" value="SLM47752"/>
        <property type="gene ID" value="NSJP_1580"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1580"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="108" mass="11682" checksum="ECE320B2FDD71822" modified="2017-06-07" version="1">MMQDASKGLAVIQQQLKELDRIMQETIETLNTTAGTERVAKWRVKTVAVLTDALGQKTGQDFSKIQPGPSFSNDLVEEFTDLVECFRGPLTALSKTTAQAAQRPAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I466</accession>
    <name>A0A1W1I466_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47613">
        <property type="protein sequence ID" value="SLM47613"/>
        <property type="gene ID" value="NSJP_1441"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1441"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="38" mass="4313" checksum="F1D956AD518B7044" modified="2017-06-07" version="1">MDNGLVECDQCPWTGSEHEAGQWHEANVKAVRMREGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I479</accession>
    <name>A0A1W1I479_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiol-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">resA</name>
        <name evidence="2" type="ORF">NSJP_1646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1646"/>
    <dbReference type="EnsemblBacteria" id="SLM47818">
        <property type="protein sequence ID" value="SLM47818"/>
        <property type="gene ID" value="NSJP_1646"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1646"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="37"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="186" mass="20871" checksum="8B49D43A5DE9809B" modified="2017-06-07" version="1">MGRRLHSVIKLGTAFGLIVLATVLELPGAWSMGSRAPFAGSLAEDFHLPDLHGDVHSLNQYRGRVVLVNFWATWCKPCTTEMPAMQNCYDRLRDKGFVVLAINELEDDQKVREHVKQYGHTFPILMDRDNKVANQFGVYGLPVSVFVDEMGVVQEYIKGGLLTEQKIYDIVARIQSQEPGRSPGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4D2</accession>
    <name>A0A1W1I4D2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fatty acid desaturase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_1690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1690"/>
    <dbReference type="EnsemblBacteria" id="SLM47862">
        <property type="protein sequence ID" value="SLM47862"/>
        <property type="gene ID" value="NSJP_1690"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1690"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="8">
        <location>
            <begin position="50"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="305" mass="35347" checksum="D88EC109E4D61FB0" modified="2017-06-07" version="1">MLSEGPVVATSPDQSIPPKSPGFCWWESLPFVAIHLLCLAAILTGVRWEWVVLAVVSYYVRMIGVTAGYHRYFSHRSFKTSRMFQFLLAFWAMTSAQKGVLWWAAHHRHHHKYSDRKEDFHSPLQRGFWYSHVGWILSDDHVKTDLTLVKDLSRYPEIRFLDRFYFLPPFVYGGLLYLLWGFPGLVWGFFISTTALYHCTFFINSLTHLFGTVRYRSGDGSRNSLILALLCCGEGWHNNHHHYQIAANQGWFWWEVDLSYYVLVVLSWVGLVWDIRTPPPQIKAATIATELSFRSDGPQAPAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4G1</accession>
    <name>A0A1W1I4G1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1726</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47898">
        <property type="protein sequence ID" value="SLM47898"/>
        <property type="gene ID" value="NSJP_1726"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1726"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011922">
        <property type="entry name" value="Cell_div_FtsL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04999">
        <property type="entry name" value="FtsL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="104" mass="11827" checksum="E24C68593F28CD37" modified="2017-06-07" version="1">MKAIMMLLGLALVFLFVWERVDVVRLGYQIERLKAQKVLLVRERDQLQVKVSTLAAPERIARVATEKLGLLPPQQGQVFLVRQQQEAPVPSSPVVEQIRVARNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4H0</accession>
    <name>A0A1W1I4H0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ddlB</name>
        <name evidence="7" type="synonym">ddl</name>
        <name evidence="11" type="ORF">NSJP_1736</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1736"/>
    <dbReference type="EnsemblBacteria" id="SLM47908">
        <property type="protein sequence ID" value="SLM47908"/>
        <property type="gene ID" value="NSJP_1736"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1736"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="93"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM47908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="315" mass="33803" checksum="597F423D64231317" modified="2017-06-07" version="1">MGGQSSEREVSLRTGSAVHRALCRRGYDAVAIDVGPALSRDLQRHRIALAFLALHGPGGEDGSIQGFLETLGIPYTGSGVQSSSVGMHKVTTKTILAAYDVPVPPGLVVKRGQIVSESRTLRAAKLRWPVVVKPASEGSTIGVTIVKERAQWKKALALAHRYDRDAVVEAYIPGHEVTVSLLGRGGRAPLVLPAVEIVAPGGFYDYSAKYEKGKTRYLCPAPLPAGVTKEIRAQALRAYEVLDCAGAIRVDFRITPRGRPYVLEVNTAPGMTETSLLPMAAAQAGIGYEELTERILESAVARMSSHRPTGRSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4K8</accession>
    <name>A0A1W1I4K8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="9" type="ORF">NSJP_1581</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1581"/>
    <dbReference type="EnsemblBacteria" id="SLM47753">
        <property type="protein sequence ID" value="SLM47753"/>
        <property type="gene ID" value="NSJP_1581"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1581"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="24"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="272" mass="29822" checksum="993870C34848C4E3" modified="2017-06-07" version="1">MVPDHPFPPANKRLGQHFLIDPNIIRKIVTAAAVTPDDTVLEIGPGRGALTAALSKAARRVVAVEIDPLLHRLLQDRQTEWPNVELICADALKYPTDGFPTGTAVVANLPYYASTPLLFRLLEQRTRWSRMVLMLQEEVVDRLIAGPGRPDYGVLSVMAQHVAEMTKEFYVSPHCFRPKPDVGSAVVSVRPKTLPDRSVEEESRFGALVRGAFAHRRKTLVNSLRDEAYDQKSVTAALDALGISVTARAENLSVAQFVSLEARLSGSPSSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4N1</accession>
    <name>A0A1W1I4N1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ssb</name>
        <name evidence="6" type="ORF">NSJP_1763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1763"/>
    <dbReference type="EnsemblBacteria" id="SLM47935">
        <property type="protein sequence ID" value="SLM47935"/>
        <property type="gene ID" value="NSJP_1763"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1763"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="136" mass="14997" checksum="7D404822FE4A3D6B" modified="2017-06-07" version="1">MAGFNKVILLGNLTRNPELRYTPNGTPVATLGLAVSRRYKQGEDLKEEVCFVDIVVFGKQAEHCGQYLSKGNGVIVEGRLQHRRWETEDGQKRSKHEVVAQTVTFMPKRGDTGGGGGGSDPAGHHEEPAYEYEDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4W7</accession>
    <name>A0A1W1I4W7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48040">
        <property type="protein sequence ID" value="SLM48040"/>
        <property type="gene ID" value="NSJP_1868"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1868"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="91" mass="9630" checksum="62EA9A51688CCE3B" modified="2017-06-07" version="1">MTAILNLIYCWLLDLLAKLTDIALNAWDSVLGPADAILASLGTGSLTVPVIPAQYAWILGATGMAQAVAIIATAMLVRFTLQSVPFVRWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4X8</accession>
    <name>A0A1W1I4X8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpsN</name>
        <name evidence="6" type="ORF">NSJP_1878</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1878"/>
    <dbReference type="EnsemblBacteria" id="SLM48050">
        <property type="protein sequence ID" value="SLM48050"/>
        <property type="gene ID" value="NSJP_1878"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1878"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00537">
        <property type="entry name" value="Ribosomal_S14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023036">
        <property type="entry name" value="Ribosomal_S14_bac/plastid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="101" mass="11805" checksum="D11375922DFFB50F" modified="2017-06-07" version="1">MAKLSSHLRNEKRKQLVAKYAERRHALKTIIKSQRSTHEEKRVAQSALNRLPRNSSPVRVRNRCALSGRVRGFLRRFNMSRIDFRLLALRGDIPGVRKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I551</accession>
    <name>A0A1W1I551_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1975"/>
    <dbReference type="EnsemblBacteria" id="SLM48147">
        <property type="protein sequence ID" value="SLM48147"/>
        <property type="gene ID" value="NSJP_1975"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1975"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="11"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="100"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="149" mass="16768" checksum="DFE7F25515C5EAC8" modified="2017-06-07" version="1">MAESEPTVTDPSCRACGGHWPATDHLVMDLGLSKAFLHDDQYFAGWTVIVFKRHATELFHLAPTERIQLMEEVNVAAKALAETFGAKKINYELLGNQLPHIHWHVIPRLAADPAPLEPVWRVPHEPVRLTGVDLQDRLRSIAEALARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5C7</accession>
    <name>A0A1W1I5C7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1959"/>
    <dbReference type="EnsemblBacteria" id="SLM48131">
        <property type="protein sequence ID" value="SLM48131"/>
        <property type="gene ID" value="NSJP_1959"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1959"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="145" mass="16286" checksum="628A37C9ECDFECFC" modified="2017-06-07" version="1">MANDWSASILLIDGNHREREYYAHRLRMSSPEYEIFQALDGQSGLQYCQERLFDCVVLELNLPDMSGFEVLLKLVPRPRCPEIPVVVLTQLANEALLKAALVNGARACLQKNFTSGDLLEEAILKAMATVGTLRKEQGDFNQSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5F0</accession>
    <name>A0A1W1I5F0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Aminomethyltransferase</fullName>
            <ecNumber evidence="4">2.1.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.2.10" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2075"/>
    <dbReference type="EnsemblBacteria" id="SLM48247">
        <property type="protein sequence ID" value="SLM48247"/>
        <property type="gene ID" value="NSJP_2075"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2075"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GcvT_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCV_T" evidence="2">
        <location>
            <begin position="7"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="3">
        <location>
            <begin position="284"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="364" mass="39618" checksum="D4D923F640921682" modified="2017-06-07" version="1">MPKQSRLHDHHIRLGAAFEDVTGWSMPAHYGDVAAEHRAARESVGLADLSHRGKLRVTGEDRVKWLQSVISNDLLPLQPGQGRYSSFLTHKGKMLTYFRVYMLADAVMLEDVGEIGETTYSALRKFLLYGTKAKMDNGAETWGLLLVSGPKAAMSVKAAFGADVTDLKPVNFVPATIGGQAALIVRTEETGEEDYEILLPADGLITAWERLIEAGKAYGIRPMGSQAREALRIEAGIPKAGPDLNEDIVPPEANLESKAFSLSKGCYPGQEVVTRMDTYGNVRRHLVGLVVKDSTVPPKGAKLFSGDREIGWISSATRSPQMNAVIALGFPLRDFSTAGSALSIDIDGTRHDATVHTLPFYQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5S1</accession>
    <name>A0A1W1I5S1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Biopolymer transport protein ExbD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">exbD</name>
        <name evidence="8" type="ORF">NSJP_2047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2047"/>
    <dbReference type="EnsemblBacteria" id="SLM48219">
        <property type="protein sequence ID" value="SLM48219"/>
        <property type="gene ID" value="NSJP_2047"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2047"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="124" mass="13744" checksum="7DF141E0F6B2752B" modified="2017-06-07" version="1">MEREIDQINVIPLVDVMLVLLVIVMTTATFITTGHIPVDLAKAKESGERKDVPLVITLSSDGSLFLNDQPVSQEGLKVQLISHSRESLVLVRADRITVLERFVNVVDDVRGLGFHQVSLEVLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5T8</accession>
    <name>A0A1W1I5T8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">asd</name>
        <name evidence="14" type="ORF">NSJP_2021</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2021"/>
    <dbReference type="EnsemblBacteria" id="SLM48193">
        <property type="protein sequence ID" value="SLM48193"/>
        <property type="gene ID" value="NSJP_2021"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2021"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="15"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="43"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="164"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM48193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="339" mass="37166" checksum="7492DB08C2686893" modified="2017-06-07" version="1">MKKKSKYVLGILGATGAVGKETLDILDERKFPLESLRLFASKRSAGEVLSCQGREWKVEELTPETSFAGIDFALISATDAISREYGARLSAAGILVIDDSGVFRMEDDVPLVVPEVNRQALRSMPRRIVSIPNCTTTPLVMALKPLQEAAGIKRVVVTTFQSVSGTGAAAMDELMNQTRNLMAFREAKAEVYPYQIAFNLLPHIGSFNEGGDCSEEIKIMRETRKILEAPALRLTATTVRVPVLRCHSEAINVELERPLKPHDARAALAEMPGVLVYDDPSKKLYPMPLDATGKDDVFVGRIREDESTANGLNLWVVSDNLRKGAALNAVQIAECLTEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5U0</accession>
    <name>A0A1W1I5U0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Uroporphyrinogen decarboxylase</fullName>
            <shortName evidence="8">UPD</shortName>
            <shortName evidence="8">URO-D</shortName>
            <ecNumber evidence="4 8 9">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">hemE</name>
        <name evidence="13" type="ORF">NSJP_2192</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8 9">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 8 9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2192"/>
    <dbReference type="EnsemblBacteria" id="SLM48364">
        <property type="protein sequence ID" value="SLM48364"/>
        <property type="gene ID" value="NSJP_2192"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2192"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="12">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="23"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM48364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="341" mass="38103" checksum="9B1DA23FD368ED66" modified="2017-06-07" version="1">MNDRFLKACRREPVDCTPVWFMRQAGRYMTEYRSLRAKHSMLELCKTPELAAQVTLQPIERFPLDAAIIFADILLPLEAMGLHLEFAEGEGPVIHNPVRERADVERLRLIEGGELEYVCDAIRQARQALHGRVPLIGFAGAPFTLASYAIEGGGSRNYVLTKSIMYREPDVWHKLMDKLARVVTGYLRRQIKAGAQAVQLFDSWVGCLSAGDYTEYVLPHVQLIFEGLKREGVPMIHFGTGTTAILKHMRAAGGDVIGVDWRVPLDEAWSLIGHDRAVQGNLDPVALYGPLGEIERRVEDILRRAAGRLGHIFNLGHGILPTTPVEHVEAAISMVHKLSMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5X0</accession>
    <name>A0A1W1I5X0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2169</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2169"/>
    <dbReference type="EnsemblBacteria" id="SLM48341">
        <property type="protein sequence ID" value="SLM48341"/>
        <property type="gene ID" value="NSJP_2169"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2169"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012280532" description="Fibronectin type-III domain-containing protein" evidence="2">
        <location>
            <begin position="36"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="255"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="346" mass="35395" checksum="03423A961B3C6839" modified="2017-06-07" version="1">MITCRARNLFSIKTPTLRDLVACLAILSAAAPAFGADPAVGTRHSLILRPVAEKMRAMASVSSLENQADPGAASAPSASLPRKLAKYPAVERIQVIAETQTTTPGSARQSQSQTNSIPAVQPVPVVSVGPGQRPASAINLSSTSRTVPIAAAGPIQAAQQPMAVAHPVQPIAASGTGSSNGYGGSRAALNLFNIRGLVNLVHAPLPPVVTPSSTAPTAPKSTPQTAPSTSSNPPPSSSSGGSTPNPQTSTPSSNQPSNAPAPVQKTGNAILSWNIGTENDLAGYKVYVGTRSGTYSYPGSPFTIGRVTTYTLNNLPQGQTYYFALSAYDNAGNTSGLSAEVHKSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5X4</accession>
    <name>A0A1W1I5X4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48406">
        <property type="protein sequence ID" value="SLM48406"/>
        <property type="gene ID" value="NSJP_2234"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2234"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="69" mass="7775" checksum="174E5DFF2DBB2B75" modified="2017-06-07" version="1">MDCIVIRNSWRKGIHMTPLLVLKSLIYSVPTESFLNLLIKEALGGNINRSLQKCSTLYETGANLPCHCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Y3</accession>
    <name>A0A1W1I5Y3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase Obg</fullName>
            <ecNumber evidence="5">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">obg</name>
        <name evidence="9" type="ORF">NSJP_2107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2107"/>
    <dbReference type="EnsemblBacteria" id="SLM48279">
        <property type="protein sequence ID" value="SLM48279"/>
        <property type="gene ID" value="NSJP_2107"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2107"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="8">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="7">
        <location>
            <begin position="159"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="165"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="311"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="341" mass="36604" checksum="95C37AF240C76571" modified="2017-06-07" version="1">MFVDEVSIVVKAGRGGNGVCSFRREMFVPRGGPDGGDGGNGGHVIFTTSQRLTTLLDLRYQRHYEAEDGRPGSGSNCTGRTGRDVVVTVPVGTVVYDELSGDMLADLAADGETVTVARGGKGGRGNSHFATSTNRVPTRFEPGTDGEERELRLKLKLLADVGLVGYPNAGKSTLIAAISAARPKIADYPFTTLVPNLGVVRWGSDRSFVVADIPGLIAGAHEGKGLGFQFLRHIERTSFLLHLVDVSEWSADEPVTSFEIMRKELSSYDASLSARPFAIVPTKLDAAGDRAKLKTLQMYCKRRKYPCLPISAATREGLTELVSFVGQQVDHLRTAGCATKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Y8</accession>
    <name>A0A1W1I5Y8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator, contains GGDEF domain</fullName>
            <ecNumber evidence="4">2.7.7.65</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.65" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2255"/>
    <dbReference type="EnsemblBacteria" id="SLM48427">
        <property type="protein sequence ID" value="SLM48427"/>
        <property type="gene ID" value="NSJP_2255"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2255"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052621">
        <property type="term" value="F:diguanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="190"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="334" mass="37020" checksum="E3235B4A604D6F59" modified="2017-06-07" version="1">MSILIIDDSPDDRALLQSILSAAGYDHILSAESATTAFRLLGMEGGKQSAGRIDLILMDIVMPEMNGIEACRQIKAVERYRDTPIIMVTVKTDPVDLQLAFAAGALDYIAKPINKIELLTRVRSVLRLVHEIERRRAHEQELLEVMRQLQEANQMLLRLSCLDGLTGITNRRQFDDFLDQEWRRAVRESTPLSLIMLDIDRFKSYNDTQGHTVGDECLRQVANAISGAVNRPGDLVARYGGDEFVVVLPGTTTEGAAQVAETLRRRIESLGITHSEGDVMTISVGYASTIPNRSASQTDLIKAADQALYQAKQEGRNRAKQAGILSLVPHSHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I606</accession>
    <name>A0A1W1I606_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48430">
        <property type="protein sequence ID" value="SLM48430"/>
        <property type="gene ID" value="NSJP_2258"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2258"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="72" mass="7899" checksum="36981DED616013E4" modified="2017-06-07" version="1">MASETSEHERVRRIGVALVVSAVMLATAGCSSEQPKPMPQPTPDQVRSHGDRTFDKLKQEEQERGAQPSAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I619</accession>
    <name>A0A1W1I619_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48444">
        <property type="protein sequence ID" value="SLM48444"/>
        <property type="gene ID" value="NSJP_2272"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2272"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="78" mass="8851" checksum="6D6D23A133848192" modified="2017-06-07" version="1">MILAGMSVSGNPCGRRLEKKEVFHERSSSARVKRYCKKKRAVRANKTRKNHLAEGVYPVAGIVRLRVKQALFGRGERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I652</accession>
    <name>A0A1W1I652_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48474">
        <property type="protein sequence ID" value="SLM48474"/>
        <property type="gene ID" value="NSJP_2302"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2302"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012641930" evidence="1">
        <location>
            <begin position="22"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="148" mass="16661" checksum="9F07E96C44A3642A" modified="2017-06-07" version="1">MIAILPRIALCLSLLGTLACAGPSIPHEPDIIDVMLPVPAEQVRIAVIDVLTDGGYTVEPKDDEQMVTSHRRDMRGPWDWMLDWRFGTGKSWVEAKVTPASEDSTRLKLHVFYQGKDGLFTRWEDSRTALPQSAENQLRLIKNALHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I677</accession>
    <name>A0A1W1I677_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48333">
        <property type="protein sequence ID" value="SLM48333"/>
        <property type="gene ID" value="NSJP_2161"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2161"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="165" mass="19248" checksum="3D9C643169341248" modified="2017-06-07" version="1">MDRDQALEALRERILAFATLRASKDLAEDLAQDVLVVLHDKYARVTELTELVPLAFQILRFKMLDFHRKALRRGEYNQTSIDDLPLADPGDDPAVLLDRRRRVDRLLGAIDRLGERCRELFRLKLEGASFPDIQRLMGQRSINTIYTWDLRCRKQLLQLMGGNWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I686</accession>
    <name>A0A1W1I686_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48343">
        <property type="protein sequence ID" value="SLM48343"/>
        <property type="gene ID" value="NSJP_2171"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2171"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="48" mass="5365" checksum="B8BE5FCC6A36C868" modified="2017-06-07" version="1">MCGDVPSSFHAVIAMSVPNLCLTEPKQLCHRSDTEVCNLTRKFPFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6C8</accession>
    <name>A0A1W1I6C8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">rplA</name>
        <name evidence="10" type="ORF">NSJP_2329</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2329"/>
    <dbReference type="EnsemblBacteria" id="SLM48501">
        <property type="protein sequence ID" value="SLM48501"/>
        <property type="gene ID" value="NSJP_2329"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2329"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM48501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="230" mass="24571" checksum="838E5A2C93400239" modified="2017-06-07" version="1">MGKKMKAALDKVEPRQYALREAVGVVKGTAYAKFDESVDLAIRLGVDPKRSDQMVRGTTSLPHGTGKKMRVLVFAKGEKEQEARQAGADFVGSDDLMEKIKGGWMEFDSAIATPDLMAAVGKLGKVLGPRGLMPNPKTGTVTFEVGKAVGEIRKGRVEYKVEKAGIVQVPVGKVSFNADQLYDNASAVLEAVVKARPASCKGRYLKSVTISSTMGPGVKLDAAAIAKQWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6I4</accession>
    <name>A0A1W1I6I4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2466"/>
    <dbReference type="EnsemblBacteria" id="SLM48638">
        <property type="protein sequence ID" value="SLM48638"/>
        <property type="gene ID" value="NSJP_2466"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2466"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007263">
        <property type="entry name" value="DCC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04134">
        <property type="entry name" value="DCC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="148" mass="16486" checksum="ED1172D8E2034C40" modified="2017-06-07" version="1">MKDRHDHIERPAIQGSAPCTLVYDGHCQLCVTAKTQLEQRTAGRSETPVRMVPYDGEEARRLLGSAYRPGRPDVAFLIDSTGTITTGLDAFLPLLPAMRGGAVLARFFRLPLIRPMARLLYRMVAKHRYRLFGEARLPQEPSSSPPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6M6</accession>
    <name>A0A1W1I6M6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2478"/>
    <dbReference type="EnsemblBacteria" id="SLM48650">
        <property type="protein sequence ID" value="SLM48650"/>
        <property type="gene ID" value="NSJP_2478"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2478"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="1">
        <location>
            <begin position="79"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="182" mass="19245" checksum="09736014C5318079" modified="2017-06-07" version="1">MLGAIHANDRGVFEVLLMAWDGKSDPAPPQLQCVMGGVRFGQTQLGAMAQAFTYAMQRTSGFPHGGTVTVRGAAYRPVGSDGPSGGAAMAVGFIALFKGDRIQRGIAMTGTLEHDGRIGTVGGIPDKIRAAKREGYHTVLVPGGQLHDAGWNLNELALHLNIAVKEVHTVDDAYHLMTGNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6N8</accession>
    <name>A0A1W1I6N8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2505"/>
    <dbReference type="EnsemblBacteria" id="SLM48677">
        <property type="protein sequence ID" value="SLM48677"/>
        <property type="gene ID" value="NSJP_2505"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2505"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013297652" description="OMP_b-brl domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl" evidence="2">
        <location>
            <begin position="47"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="199" mass="21350" checksum="7608AEDCA55D2BF9" modified="2017-06-07" version="1">MKVRSFGRTAIMWSVLAGCVGLSGPALSLAAEESGHDGGARPGEIVAGFRVGPSFSTTPFLSTVGPNLNFQGLYGLNKYIRVGMTLDWEQHKISDNGQGTFGVSGQFSTVTLLPAYMEYRPGHFGQVYPYVGTGIGVNINNKDVSNTFAWRAAGGIDYYIMKDLALNTEVKYTRNTTDGLDLGSVALLFGLRMSFGGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6R6</accession>
    <name>A0A1W1I6R6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="5">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NSJP_2512</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Fe(III)-[cytochrome c] + H2O + nitric oxide = Fe(II)-[cytochrome c] + 2 H(+) + nitrite</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2512"/>
    <dbReference type="EnsemblBacteria" id="SLM48684">
        <property type="protein sequence ID" value="SLM48684"/>
        <property type="gene ID" value="NSJP_2512"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2512"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02376">
        <property type="entry name" value="Cu_nitrite_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0349">Heme</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012686948" description="Copper-containing nitrite reductase" evidence="13">
        <location>
            <begin position="31"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="14">
        <location>
            <begin position="382"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SLM48684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="492" mass="52088" checksum="D8C1757FF5425D86" modified="2017-06-07" version="1">MPRYGSQFEVKKLVLPVILSVALGSTSWAAAPSTPPTKPAKGQSGASAGKSNQQADATIRAVLSAAPSVPPPVKRSRPAKVIVELEVSEVTLPLSEGVDYTFWTFGGTVPGKFIRVRQGDVVEFHLMNHPDSRFPHNIDLHAVTGPGGGAASSNTAPGRRTQFSFTASNPGLYVYHCATAPVGEHVANGMYGLILVEPPGGLSPVDREYYVMQSDVYTAGKYHEKGHQPFDMGKAVEEHPTYVVFNGAEGSLLGEKALKAKVGERVRLFVGNGGPNLVSSFHVIGEIFDRVYAEAGTKYSEHIQTTLVPAGGAAIVEFKVEVPGSYKLVDHSILRAFNKGALGELKVEGQENKLVYSGKQAESDYHPTGAVAKAASPPPTKDSHASGEPLYKTYCMGCHQAEGQGIPGTFPPLAKSDYVAGETAQVIELVLNGFSGPLHVNGETYNGTMPPMGHLKDEEIAEILSYVRSSWGNAGASVSAAEVAAVRAKTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6S8</accession>
    <name>A0A1W1I6S8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_2513</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2513"/>
    <dbReference type="EnsemblBacteria" id="SLM48685">
        <property type="protein sequence ID" value="SLM48685"/>
        <property type="gene ID" value="NSJP_2513"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2513"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012912928" description="Cytochrome c domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="23"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="111" mass="11567" checksum="EA4D6A0D826653E1" modified="2017-06-07" version="1">MALFVCVFSALLLARARDAGAAGDAARGKAIYEKHCLVCHGPQGKGDGPTGTLVKPPAADFTSEASKKKSEGQLLETVEKGRLGTAMGPWKGLLPPADLGDVLAYVMTLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6T2</accession>
    <name>A0A1W1I6T2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">ATP-dependent DNA helicase RecG</fullName>
            <ecNumber evidence="3 6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">recG</name>
        <name evidence="10" type="ORF">NSJP_2469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2469"/>
    <dbReference type="EnsemblBacteria" id="SLM48641">
        <property type="protein sequence ID" value="SLM48641"/>
        <property type="gene ID" value="NSJP_2469"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2469"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004609">
        <property type="entry name" value="ATP-dep_DNA_helicase_RecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033454">
        <property type="entry name" value="RecG_wedge"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17191">
        <property type="entry name" value="RecG_wedge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00643">
        <property type="entry name" value="recG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="414"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="594"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM48641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="840" mass="93005" checksum="C68219EC7F1FD52F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Y8</accession>
    <name>A0A1W1I6Y8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48782">
        <property type="protein sequence ID" value="SLM48782"/>
        <property type="gene ID" value="NSJP_2615"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2615"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021796">
        <property type="entry name" value="DUF3365"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11845">
        <property type="entry name" value="DUF3365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013071460" evidence="1">
        <location>
            <begin position="28"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="264" mass="28890" checksum="B753D96AA2E5FB61" modified="2017-06-07" version="1">MVEREVDMSRGLIRASRAACMASLVFATVMALPAGSASNPVDDATETARLLAILLDTGRVTVADYQEVINDPGRGDKGFTPEVFEQRLKEQFRLRTGLSLAQMDTEQVPDMAKPLLSQLVEESKKTIASYQPVINIMGIRYKGLIPATFGTETATRFHTRSGVYLKQTAPQLFVRNPKNAPDSYETESFARLATLPPGSKPDLVQAEVMDQGQNVRVMLPLYYGKACLSCHGEPKGQRDISGYPREGAKEGELGGAISVRIPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I729</accession>
    <name>A0A1W1I729_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">General secretion pathway protein E, contains GAF domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gspE</name>
        <name evidence="3" type="ORF">NSJP_2618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2618"/>
    <dbReference type="EnsemblBacteria" id="SLM48785">
        <property type="protein sequence ID" value="SLM48785"/>
        <property type="gene ID" value="NSJP_2618"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2618"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="581"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="773" mass="86569" checksum="3323276E7B2D59BC" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I743</accession>
    <name>A0A1W1I743_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48826">
        <property type="protein sequence ID" value="SLM48826"/>
        <property type="gene ID" value="NSJP_2659"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2659"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="66" mass="7353" checksum="D3EDE54BBE9BF3E3" modified="2017-06-07" version="1">MFPSTSYDIHIPTLHERLTTISDMTGPAGLETAGTIARSADADRNDPDDSARQEISRWRSACRFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I762</accession>
    <name>A0A1W1I762_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">STN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_2711</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2711"/>
    <dbReference type="EnsemblBacteria" id="SLM48878">
        <property type="protein sequence ID" value="SLM48878"/>
        <property type="gene ID" value="NSJP_2711"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2711"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0798">TonB box</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="STN" evidence="10">
        <location>
            <begin position="125"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="906" mass="97946" checksum="9438385D7BEFED50" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7G5</accession>
    <name>A0A1W1I7G5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sulfate transport protein (ABC superfamily, membrane)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysW</name>
        <name evidence="11" type="ORF">NSJP_2821</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2821"/>
    <dbReference type="EnsemblBacteria" id="SLM48988">
        <property type="protein sequence ID" value="SLM48988"/>
        <property type="gene ID" value="NSJP_2821"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2821"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011866">
        <property type="entry name" value="CysW_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005667">
        <property type="entry name" value="Sulph_transpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406">
        <property type="entry name" value="PTHR30406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406:SF1">
        <property type="entry name" value="PTHR30406:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00969">
        <property type="entry name" value="3a0106s02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02140">
        <property type="entry name" value="permease_CysW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="73"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="304" mass="32616" checksum="E2C7DD4383E5DA2F" modified="2017-06-07" version="1">MTTRTAAKISNEEWTASLTTEGTLVRLALIAAALGYLTLFLFIPLAAVFTEAFKGGVLTYLASFQDPDALAAIRLTLIAASIAVPLNALFGMAAAWAIAKFEFVGKQLIITLIDVPLAVSPVISGLIYVLLFGAQGWLGPWLAEHDIKIIFALPGIVLATIFVTVPFIARELIPLMQSQGREEEEAALTLGASGWQTFLRVTIPNIKWSLLYGVILCNARAMGEFGAVSVVSGHIRGLTNTMPLHVEILYNEYNAVAAFAVASLLTLLALVTLVAKTLIERRSIAPLSRSTPDRPQPQRAGSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7L9</accession>
    <name>A0A1W1I7L9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48859">
        <property type="protein sequence ID" value="SLM48859"/>
        <property type="gene ID" value="NSJP_2692"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2692"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="PTHR43675"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="79"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="286" mass="30369" checksum="24D9E21CA5023DB1" modified="2017-06-07" version="1">MNRPADIKAHVRDEYGQAARQAQSDKPSCCGTGHVLQGDALDPITGNLYGAEETAELPAEALRASFGCGNPTVLASIQPGETVLDLGSGGGIDVLLSARRVGPTGKVYGLDMTDEMLVLARENQRKVGMTNVEFLKGDIEQIPLPDQSVDLILSNCVINLAPDKDRVATEAFRVLKPGGRLAVSDIVIRGEMPVEIRHSVELWAGCVAGALEESVYRETLRRAGFEQITIEPTRVYSAADARGFLLGAGLDVETVAHSIDGKFMSGFVRAIKPASAKTCCGPSCCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7N5</accession>
    <name>A0A1W1I7N5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_2849</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49016">
        <property type="protein sequence ID" value="SLM49016"/>
        <property type="gene ID" value="NSJP_2849"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2849"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="216" mass="24023" checksum="CEACE707E3B8097C" modified="2017-06-07" version="1">MQRPRVLFADDHRLLVEACTKLLEAECDVVGSAADGRTLLLMARGLRPDVVVLDIGMPLLNGLDAGRQLKAMMPEIKLVFLTMNEDADLTAEAFRIGASGYLLKSSAASELSGAIRAAMEDKTYIGSRMTGKIVQAYIEPGRRSMPSRLTLRQREVLQLLAEGYSMKEAANILDVTPRTVAFHKYRIMEQFQVKNNAELYQFAVKQSLIPASPRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7U5</accession>
    <name>A0A1W1I7U5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2888"/>
    <dbReference type="EnsemblBacteria" id="SLM49055">
        <property type="protein sequence ID" value="SLM49055"/>
        <property type="gene ID" value="NSJP_2888"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2888"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="193" mass="20451" checksum="E386E073FEF8D26C" modified="2017-06-07" version="1">MIAFRMLDQLSRNWGWIALRGVAAVIFGVLAFAWPGVTLVVLALFFGAYALIDGICALVAAYRGREGSTPVWPLVLIGLLGVAAGIATFLWPEMTALALLMFIAFWALLIGIAQIAAAIRLRKEIDNEWILGTSGALSVLFGVLMIASPGAGALAVAWIIGGYSVAFGLLLIVLSLRLKKVADRMAPKLSAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7V0</accession>
    <name>A0A1W1I7V0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="3">DERA</shortName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="3">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">deoC</name>
        <name evidence="4" type="ORF">NSJP_2961</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2961"/>
    <dbReference type="EnsemblBacteria" id="SLM49128">
        <property type="protein sequence ID" value="SLM49128"/>
        <property type="gene ID" value="NSJP_2961"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2961"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="3">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="226" mass="23880" checksum="D764FBF5840DC357" modified="2017-06-07" version="1">MSDGSWNLPAVIDHTILRPEATRHDVVRLCEEARTHGFTVIFVPPCYVQEAAEILAGAAIRVGIPVGFPLGGHSTAAKVAEATEGVAHGATVVDMVINISRLKSGDTDAVRRDIAEVVTATPSAEHKVIIETCYLTLQEKITACRLAVEARADYVKTSTGFGPAGATAADVRLMKEQVGGKAKVKASGGIRNWAATRALLEAGADRIGTSASLAIVAEWKLERSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7W4</accession>
    <name>A0A1W1I7W4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-54 dependent transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_2917</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2917"/>
    <dbReference type="EnsemblBacteria" id="SLM49084">
        <property type="protein sequence ID" value="SLM49084"/>
        <property type="gene ID" value="NSJP_2917"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2917"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="157"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="477" mass="53042" checksum="4466321A3808054B" modified="2017-06-07" version="1">MRARILVVDDDQDILLGLENRLTWMGHEPLTADNGDDGLRIIHRDEPDLVLLDIQLPGLSGFDILQQLRDKTDKERAGNDPAAVGIGPTDPPIIMLTAFGTIERAVQAMQLGAVDFVTKPFTGEHLTVVINKALSAISLRRQLHQLKQEVAEKHGSLIGENTKLQAQLKVAKQAAPSNVTVLVLGETGTGKEVVARAIHDWSPRKDKPFVAVNCAAIPKDLLENELFGHEKGAFTGAVKREAGKIEIAEGGTLFLDEIGDMSLSMQSHLLRVLGDQTFYRVGGTQSVKADVRFLAATNKDLKQAIKQGTFREDLFYRLEVITVNLPPLRERMDDLPALAQYFLARASGRLGIQKRASLNDSALRLLSDYRWPGNIRELENVLTRAYILSPEERIEPEHLHLSVSAPSTSPDGAPVPSSRHYHDMTEAYSRWVIEEALKRNDWNQTRASAELGLQRTYFTKLLRQKQICGRPPKQDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I857</accession>
    <name>A0A1W1I857_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49197">
        <property type="protein sequence ID" value="SLM49197"/>
        <property type="gene ID" value="NSJP_3030"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3030"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="617" mass="64771" checksum="C715C7F9F355C14F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I861</accession>
    <name>A0A1W1I861_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48993">
        <property type="protein sequence ID" value="SLM48993"/>
        <property type="gene ID" value="NSJP_2826"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2826"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="243" mass="26920" checksum="B795C54E84E4D722" modified="2017-06-07" version="1">MNQVSRHIHHTALRLSLPLIALLGTTFIGCAGTSPEPTKTIYESGLNTVRLETDPDSTSNAHPATLSATEIGTILGNVRAWEQRNFIHRLFSGEADRTRAFRHEEVQILAPALSKGLAQASPAQRVFFHLSHATEHGEEESTTGWLSIRNGTLYLSLSEVHDLHGPGPDISKYDRQMPNVPERSAAFNVTFEPEDYLIKVRSGGRLFSPDQREELQIRYRDALAALPVYPGLEPHQSGKPSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8D8</accession>
    <name>A0A1W1I8D8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lipid A export ATP-binding/permease protein MsbA</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">msbA</name>
        <name evidence="10" type="ORF">NSJP_3093</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3093"/>
    <dbReference type="EnsemblBacteria" id="SLM49260">
        <property type="protein sequence ID" value="SLM49260"/>
        <property type="gene ID" value="NSJP_3093"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3093"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="336"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="369"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM49260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="574" mass="63701" checksum="D8A158AC7193C4EB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8V8</accession>
    <name>A0A1W1I8V8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49233">
        <property type="protein sequence ID" value="SLM49233"/>
        <property type="gene ID" value="NSJP_3066"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3066"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="116" mass="13088" checksum="BA62A7A6C398E0BA" modified="2017-06-07" version="1">MSRTLTQSSVSGCRSAARPGRRPESRGLPVAKRRRRQKHPAFLYSTTAECPWCHAAAVDLATGTCPKCGTAVAGYKEKRFVMQRRDFWQRQRNRGQRSHEDPEASQGTDIQERKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8W7</accession>
    <name>A0A1W1I8W7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3290"/>
    <dbReference type="EnsemblBacteria" id="SLM49457">
        <property type="protein sequence ID" value="SLM49457"/>
        <property type="gene ID" value="NSJP_3290"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3290"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-binding_dom"/>
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        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="16"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="519" mass="55781" checksum="5316D315A1C5EA82" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I946</accession>
    <name>A0A1W1I946_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxxC_CXXC_SSSS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49548">
        <property type="protein sequence ID" value="SLM49548"/>
        <property type="gene ID" value="NSJP_3381"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3381"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="123" mass="12665" checksum="06A1232F282D0378" modified="2017-06-07" version="1">MPIYEYLCEGCAYKFEIKQSIKDDPIAACERCGKPVQRLISSPAIMFKGSGWYVTDYSDKLKPPSAGGESTADKKEPAPAAASTAAPTTSAPPSTNTSTGTSTSAPAPTSAPASTPSTTPSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I963</accession>
    <name>A0A1W1I963_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49530">
        <property type="protein sequence ID" value="SLM49530"/>
        <property type="gene ID" value="NSJP_3363"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3363"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010694293" evidence="1">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="109" mass="12136" checksum="5216497CB2C7876F" modified="2017-06-07" version="1">MKRILLTIMIGALFSGPAWANPTHELVQQMSDPDRNAYFTKVLQDAGERCDGATKTQFQRRGNSGDAVWNVACRNKKSYSIVIHSDTKGSTMITDCATLKALHVEQCFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9D2</accession>
    <name>A0A1W1I9D2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3457"/>
    <dbReference type="EnsemblBacteria" id="SLM49624">
        <property type="protein sequence ID" value="SLM49624"/>
        <property type="gene ID" value="NSJP_3457"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3457"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="171" mass="19297" checksum="5D3B2CB5069A8734" modified="2017-06-07" version="1">MLEPTTPEGTTTGILNEATGEAAEWYERGVALKKAGLFKRAIDQFERAAADSQYALKAYAQIGLCHKSIRQYEQAVTSFRRALKSPTASARETVQLLYVLGRTLESLGRADDALEAYRWLRREDPGFRDVAERIGALSVRKPSDPTDRSRRGNPWAKQALQVWEGFLRHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9I9</accession>
    <name>A0A1W1I9I9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">tsaD</name>
        <name evidence="8" type="ORF">NSJP_3424</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3424"/>
    <dbReference type="EnsemblBacteria" id="SLM49591">
        <property type="protein sequence ID" value="SLM49591"/>
        <property type="gene ID" value="NSJP_3424"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3424"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="41"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="152"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="360" mass="37572" checksum="5DC9D42C05D5CCDD" modified="2017-06-07" version="1">MNQIKMNYSGISDARGTDGPVLGIETSCDETAAAVIRGDGTILSNVISSQHSVHARFGGVVPELASRAHIEKIEEIAARAIDEAGLSWQDLAGVAVTEGPGLAGALIVGLNYAKALAFALNIPIVGVSHLEGHIASAWLKDPSFPRSCVVLVVSGGHTHLYHRGQDGATRLLARTRDDAAGEAFDKGAQMLGLGFPGGPALDKLAQAGNPGKIRFPRSMRKSSLEFSFSGLKTSLLYRLQGMDKAHLDGIRADVAAGYQEAIVSVLVEKAFTAVGRCGVAALAVVGGVSANSRLRALLTERAHREGVLLSIPPLQYCTDNAAMIAAAGRNALSAGRRLADDAEALVTMDPLSPLQVIETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9N0</accession>
    <name>A0A1W1I9N0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49706">
        <property type="protein sequence ID" value="SLM49706"/>
        <property type="gene ID" value="NSJP_3539"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3539"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="93" mass="10375" checksum="6B02DD616C498071" modified="2017-06-07" version="1">MIKVLLFGLTLRDAVGKQDIDVEASQAATVKQLLESNQDRFGAVLPFMMNREVVIIVNRRIGTEDSPVKDGDVVKLSYQSRYSTHDGVRDIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9P3</accession>
    <name>A0A1W1I9P3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cobyrinate a,c-diamide synthase</fullName>
            <ecNumber evidence="3">6.3.5.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cobyrinic acid a,c-diamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cobB</name>
        <name evidence="3" type="synonym">cbiA</name>
        <name evidence="6" type="ORF">NSJP_3538</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine = 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:26289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="ChEBI" id="CHEBI:58894"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 10/10.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CobB/CbiA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.11" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3538"/>
    <dbReference type="EnsemblBacteria" id="SLM49705">
        <property type="protein sequence ID" value="SLM49705"/>
        <property type="gene ID" value="NSJP_3538"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3538"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00027">
        <property type="entry name" value="CobB_CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00379">
        <property type="entry name" value="cobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="5">
        <location>
            <begin position="246"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="site" description="Increases nucleophilicity of active site Cys" evidence="3">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="455" mass="49208" checksum="4F806C9220983EAA" modified="2017-06-07" version="1">MIPRLVIAGTASHVGKTTVTVGLIRALRARGFRVAVFKCGPDYLDPTYHTRAAAVTCHNLDGWMMGREAVIDTFVRTSQDADISVIEGMMGLFDGASPIHDEGSTAEIAKWLKAPVLLVCDASGMARSIAALARGFQTYDGALRVAGVIANRIGSRGHLKMLRAAMDGSLPIIGGLPDDGALAFPERHLGLKTAEEGAVPDRILEAWGKQAASWCDLDAIVALAQDAPPCESTERLGDSGPAPCCRIGLAFDEAFHFYYEDNLRRLERLGVKLVRFSPIHDDRLPDVDGLYFGGGYPEVFADTLSKNASMRKDIAVFASSGKPVYGECGGLMYLSNRIRTLDGRPHDMVGLIPGEAVMCDRLQALGYVDVETQDATPLGAAGLRFRGHQFRYSDFHLDSTVDRSYVLRPRYGGEVLREGYRIGNTLASYVHAHWASNPEAAQGLVRACLAHAGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9W8</accession>
    <name>A0A1W1I9W8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3615"/>
    <dbReference type="EnsemblBacteria" id="SLM49782">
        <property type="protein sequence ID" value="SLM49782"/>
        <property type="gene ID" value="NSJP_3615"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3615"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="423" mass="46903" checksum="93298A6569C7F736" modified="2017-06-07" version="1">MGVVYQVETVPAREVVALKLCFSDDDSMIKRFAREVRFMASVNHPHVMQVISQNTDYLPAYFTMPLAQQSISAEIIKGLSEEETLNIFKQICLGVQAIHNAGGTHRDIKPDNIMRMMDGNVVISDFGLIKLDPRDTTTLTQTAAFLGTRVYCAPEQLIPGGSRGADARTDVYQLGKTLYEMLTKETPALIERSKIPSGLTYIIEKATQQQPDNRYQSVGSLLDAVLSYVSSKSPGASPDQEYELIIQEITGLAERGQYQTENLEKLMVVLLRFAGEPETFIEQFDRIPREVLPVLARHLSPSLHRVLVSYRQIIESAIGNYSFSYAEVVANKMKAIFDHAEEPSIKAAAIAATLIAAVKCNRFAAMDVFSSMITSIRKSEDAIAIADILNEEIGYYEVIASQVPRSKIHAAIRRVYDAAVAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA12</accession>
    <name>A0A1W1IA12_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49825">
        <property type="protein sequence ID" value="SLM49825"/>
        <property type="gene ID" value="NSJP_3658"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3658"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="112" mass="12345" checksum="37CCCA8CE4706131" modified="2017-06-07" version="1">MLPEPLAQQWAALLLAMIGGAYVGFAARDGRPGANHIELAGGLLFAGIGLAGLHFNPLLIAAGYVAHGFWDLVHHRHGPYAITPRWYIPFCVVYDWIIGAFLLIWWGVRLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA31</accession>
    <name>A0A1W1IA31_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3741"/>
    <dbReference type="EnsemblBacteria" id="SLM49908">
        <property type="protein sequence ID" value="SLM49908"/>
        <property type="gene ID" value="NSJP_3741"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3741"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="32"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="122" mass="13533" checksum="80644D1986A9CD39" modified="2017-06-07" version="1">MKHNESFLRLVENARRRVKECTVAEAKNRVDRGEVAHFIDVREDNEFQQTHAKGARHLGKGIIERDIETIVPDKNAAIILYCGGGFRSVLAADALVQMGYSNVTSMDGGIKAWKEAGYPMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA39</accession>
    <name>A0A1W1IA39_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="9">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ImGP synthase subunit HisF</fullName>
            <shortName evidence="9">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">hisF</name>
        <name evidence="11" type="ORF">NSJP_3466</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3466"/>
    <dbReference type="EnsemblBacteria" id="SLM49633">
        <property type="protein sequence ID" value="SLM49633"/>
        <property type="gene ID" value="NSJP_3466"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3466"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM49633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="261" mass="27998" checksum="046BB638BC68E7C9" modified="2017-06-07" version="1">MLTKRIIPCLDVKDGRVVKGVSFVALRDAGDPVEVATAYDREGADELCFLDITASHENRKTIFDVVERTAARVFMPVTVGGGVRTIEDIRALLNAGADKVSINTAAVQRPEFVKEAAQRFGTQCIVVAIDAKHDPDGTRWGVFTHGGRNATALDAVEWAKRMEDYGAGEILLTSMDQDGRQSGYDLGLTAAVSGTVSIPVIASGGVGTLEHLYQGFVSGKADAVLAASIFHFRTFTIPQAKAFLRERGVSVRIVSGEEDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA54</accession>
    <name>A0A1W1IA54_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3705"/>
    <dbReference type="EnsemblBacteria" id="SLM49872">
        <property type="protein sequence ID" value="SLM49872"/>
        <property type="gene ID" value="NSJP_3705"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3705"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="418" mass="45757" checksum="FB3AB7E40A44A47D" modified="2017-06-07" version="1">MMMRRLPAMPLEDPEPTPQVDEVDEVHSAVHPTLRGNRKLAVAWVCATVVGGVVLWYSAASQYSPTVTLGALIGLLVGYAGYGYSVKKKNTAQFADSLYYMGFLWALLALIVTFILWPAPKLTAEAVLPAFGYALVLTCAGMVLRLLTLYFQDTLTDRLLDVQDSIDQRVSTLLHEITEANMEISSFRDLAANDLRGSLHDLVRSLSDVREKLAEQQFAMGKTMTAGLESSVKDMLSRLSTMQMPQEILTAEVSKLITVMGRRGESFEAAAQRLEDGLTRTAETVASFGESLYGAEGVGQVEAAVKELSDTLKERTEQFLSMTTAFERSRAELDGQLNGLQSLRASFASVSGRLAAFETELKDITAASMSADVKNGLLNVQKAIQSSLEASRTIETTMRDVMSFLRVRVAEEHSGDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA81</accession>
    <name>A0A1W1IA81_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49673">
        <property type="protein sequence ID" value="SLM49673"/>
        <property type="gene ID" value="NSJP_3506"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3506"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012212948" evidence="1">
        <location>
            <begin position="22"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="213" mass="23386" checksum="0AEDAA54E8796B9E" modified="2017-06-07" version="1">MIRRAIALTVIALLAACTSPALLPKPKQAVPVGSYPQDPRKGAVVLSVNWGRALKCGSYRYAQLRGFGFDRIPLQAVVDGDVPDVFIEGSPYFKESEPVNYLLAIEPGIYALTHYAIEVAASTFNVKIGTVGPSALMKNGAVIGGTFDVKQGELVYIGHFGLSCNGEPSFWRDYPDDPGTFDQYKAVIKRRYDLLDVESMQFRPFKTTLFGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAB6</accession>
    <name>A0A1W1IAB6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49964">
        <property type="protein sequence ID" value="SLM49964"/>
        <property type="gene ID" value="NSJP_3797"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3797"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="75" mass="8919" checksum="8F48D715091724C8" modified="2017-06-07" version="1">MVQFDAEARNIHDQVVSLAQPKRKIFIEFRQASSEACWEHRKQRFCFSQSVHTGLHFLKIHCLLLEVVVFINYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAP6</accession>
    <name>A0A1W1IAP6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="1">PPIase</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ppiC</name>
        <name evidence="4" type="ORF">NSJP_3895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50062">
        <property type="protein sequence ID" value="SLM50062"/>
        <property type="gene ID" value="NSJP_3895"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3895"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="59"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="213" mass="24129" checksum="D6BBF618E1F5261B" modified="2017-06-07" version="1">MYVEFATRWSDSMAMSREILRIHQYKPGLPPARPACYIRRVTMEFKKIDPRATITTKFGEIKIRFYPDAAPRHVENFMNLAKMGFFDGTTFHRIVPGFVIQGGDPLSKTADRRSHGSGGPGYWLNPELSDRPHKRGAVSMAKTPRDGSSTRDFNDNGSQFFICLDDNSGLDRRYSVFGEVFRGLDVIDKIAALPRDEFDNPLEAVTMTVTVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAV9</accession>
    <name>A0A1W1IAV9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NSJP_3884</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3884"/>
    <dbReference type="EnsemblBacteria" id="SLM50051">
        <property type="protein sequence ID" value="SLM50051"/>
        <property type="gene ID" value="NSJP_3884"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3884"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007891">
        <property type="entry name" value="CHASE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05227">
        <property type="entry name" value="CHASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="249"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="320"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="10">
        <location>
            <begin position="393"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="458"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM50051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="678" mass="76100" checksum="AF76F20B11F924B9" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB91</accession>
    <name>A0A1W1IB91_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GBBH-like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_4078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4078"/>
    <dbReference type="EnsemblBacteria" id="SLM50245">
        <property type="protein sequence ID" value="SLM50245"/>
        <property type="gene ID" value="NSJP_4078"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4078"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBBH-like_N" evidence="3">
        <location>
            <begin position="16"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="118" mass="13723" checksum="2D28A7B383944D6D" modified="2017-06-07" version="1">MAEIVLEPKDMSWIDKGVLGIEWNDGHRGVYPVRYLRQQCPCAACVDEWTGERRLKADEVPLLIMLQDIESVGRYALQFKWSDGHDTGIYSYQLLRRLCQCDLCQPIKPTQPRSRKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZP2</accession>
    <name>A0A1W1HZP2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Outer membrane chaperone Skp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Skp family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0020"/>
    <dbReference type="EnsemblBacteria" id="SLM46192">
        <property type="protein sequence ID" value="SLM46192"/>
        <property type="gene ID" value="NSJP_0020"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0020"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35089">
        <property type="entry name" value="PTHR35089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03938">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013366030" evidence="4">
        <location>
            <begin position="25"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="177" mass="19966" checksum="05A1671B22FC578D" modified="2017-06-07" version="1">MNTGLGKLLTVVVAAVACAGPVWAAESLRVAVMDQQNVIERSKAGTRALEELKAYSATRQKIINSDDQELKEMEQSLQDPNLSEQVKQERQGQFQAKIEAYQRRLADFNREIQQKQRETVAEYSKKVEDAARVVAQREGYVAILDKGNEAAVRIVIYNQPALDLTEQVVKEFDKQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I027</accession>
    <name>A0A1W1I027_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RNA-binding protein RbpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rbpA</name>
        <name evidence="3" type="ORF">NSJP_0067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0067"/>
    <dbReference type="EnsemblBacteria" id="SLM46239">
        <property type="protein sequence ID" value="SLM46239"/>
        <property type="gene ID" value="NSJP_0067"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0067"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="100" mass="10275" checksum="F9DDF6FB10B58B68" modified="2017-06-07" version="1">MGSKIYVGGLPYSTTEQQLSDLFAAHGAVASARIITDKFTGQSRGFGFVEMSNDSEAQTAITALNGTQLGGRTLTVNEARPQEPRSGGGGGRGGFGGGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I037</accession>
    <name>A0A1W1I037_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0193"/>
    <dbReference type="EnsemblBacteria" id="SLM46365">
        <property type="protein sequence ID" value="SLM46365"/>
        <property type="gene ID" value="NSJP_0193"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0193"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013094114" description="BFN domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="BFN" evidence="2">
        <location>
            <begin position="29"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="165" mass="17705" checksum="898036D3C0746C65" modified="2017-06-07" version="1">MIRSILFTLLLAGAGWSIALAEEASSKSSEPVKIADVKVRLSDHGPVVLLQAEGKAIPIFVDLTVALSIQGALNHEKLSRPLTHDLMHTILESYGGTVTQTIITLKDGTYYGALTVAVRGDTKVFDSRSSDSIALAIHFNAPIIVSRELLDSAGRTVEAPKREDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0D8</accession>
    <name>A0A1W1I0D8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46468">
        <property type="protein sequence ID" value="SLM46468"/>
        <property type="gene ID" value="NSJP_0296"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0296"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="104" mass="11467" checksum="02721948816B6AD4" modified="2017-06-07" version="1">MNRLFVTGDAPCRGLYSRLGNFGNRGLGVYTSRATRLYLSTFLRFWGQLFSDLSPDSWAPDRSLLFACSQATLIALTVTGNAPYLGACRDELPHASIESLDWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0H9</accession>
    <name>A0A1W1I0H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46506">
        <property type="protein sequence ID" value="SLM46506"/>
        <property type="gene ID" value="NSJP_0334"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0334"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="248" mass="28590" checksum="8658654AE877F96A" modified="2017-06-07" version="1">MNHRVGSRPQPIKQLRIRPGELQVKYPSSLRPSPLRKWCWQTVQTCESGCHAFAIWLGRKSRAGWQVSRDGLKRMELGVRVRRGWITLKESTLRGAVQCGHGVKVAGQWGGRMVRDAARLIVRRFERREEKRPEHMPVAGFPMARFDVYGDFHFLQPSEAKQSFRRELARSHAQLAEQLRAEEEELSRVAARVVRLQSLLRAQQSLLLGSTRDNEAERASLRAPFQSLVGVGMRSDREHEHPDLYRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0I1</accession>
    <name>A0A1W1I0I1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Tol-Pal system protein YbgF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0181"/>
    <dbReference type="EnsemblBacteria" id="SLM46353">
        <property type="protein sequence ID" value="SLM46353"/>
        <property type="gene ID" value="NSJP_0181"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0181"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02066">
        <property type="entry name" value="CpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034706">
        <property type="entry name" value="CpoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014162">
        <property type="entry name" value="CpoB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02795">
        <property type="entry name" value="tol_pal_ybgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="31"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="243" mass="26952" checksum="D3895EEDC61B0EBE" modified="2017-06-07" version="1">MAVGFLFLSGCAKHADFIELRDHLATVTKSQEQDQKRLDALQRRMETLERIKDGDGARPRFDEVSARIQKLESRLAKVEDGAASSSFSRIEPAASEPTRSKSQKPGGSMESAAIPGVPAITPTSAFNLAYNDYLNGKYDLAVSGFQRFVKDFPGTSLTPNAYYWLGESYYQQKDYVRAMQSFEYVSTEYPGNEKVPASLFKLGLAAGETGDLAKSKKNLKRVIEEFPTSDEAKLAKNKLAEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0R4</accession>
    <name>A0A1W1I0R4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Twitching mobility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pilT</name>
        <name evidence="4" type="ORF">NSJP_0271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0271"/>
    <dbReference type="EnsemblBacteria" id="SLM46443">
        <property type="protein sequence ID" value="SLM46443"/>
        <property type="gene ID" value="NSJP_0271"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0271"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01131">
        <property type="entry name" value="PilT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="392" mass="43915" checksum="90A1034B17760A29" modified="2017-06-07" version="1">MDVRTLLKVMVDQEASDMYLTVEAPPTYRVHGSTKPANMPPFTNEQLEALALALMRGQQRGEFEEKMEMNLALYYKELGRFRVNIFRQRGNVGLVFRHIKAEIQTVEQLRLPQIIKDIAMTKRGLVLVVGATGSGKSTSLAAMIDYRNEVHPGHIITVEDPIEFVHSHKKSLITQREVGFDTLSFQNALKNTLRQAPDVILIGEIRDTETMEAAITFAETGHLCIGTLHSNNANQAIERIMNFFPVERHAQIYLQLSLNLRAIISQRLVPSLDGKRVPALEIMMDTPRIKDLVKKAEIDTLKEAMEQGIEEGCQTFDHVLLQLYKEEKISLEQALINADSANNLRLKIKLEGLKGDDAINALLDKGPNATGEGAAFKLQGNPASNVTPIRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0X8</accession>
    <name>A0A1W1I0X8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein HflK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hflK</name>
        <name evidence="7" type="ORF">NSJP_0469</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">HflC and HflK could encode or regulate a protease.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">HflC and HflK may interact to form a multimeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the band 7/mec-2 family. HflK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0469"/>
    <dbReference type="EnsemblBacteria" id="SLM46641">
        <property type="protein sequence ID" value="SLM46641"/>
        <property type="gene ID" value="NSJP_0469"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0469"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03404">
        <property type="entry name" value="SPFH_HflK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010201">
        <property type="entry name" value="HflK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF2">
        <property type="entry name" value="PTHR43327:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01933">
        <property type="entry name" value="hflK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="6">
        <location>
            <begin position="51"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="344" mass="38556" checksum="93D8F1F66729FC84" modified="2017-06-07" version="1">MVWDPKDPWSKRSDPLEDVLRQAQSQFRNFLPSGGFRNILFAALLIFLIWQSAFIVGPDEEGVVKRFGIPVRALGPGPHLKIPLIETVLQPKVAKLHRVEIGFRTDRQARQQMVPQEALMLTGDMNILAIEFIVQYKIKEAANYLFNVADIHDTIGKAAEASMREVIGKSKIDEALTTGKAQIQQDTQDLLQRILDQYQTGVQIAAIQLQDVDPPEAVAAAFKDVTNAKEDREKLINQAIGYRNDILPRAKGEAAQTVNQAKGYAQARLNRAQGEANRFLATLKEYNQAKDTISKRIYIETMEEILPKVEKIILDGKAGERVLPYLPLDRHSKKMPSAPEGAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Y8</accession>
    <name>A0A1W1I0Y8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">xseA</name>
        <name evidence="9" type="ORF">NSJP_0479</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0479"/>
    <dbReference type="EnsemblBacteria" id="SLM46651">
        <property type="protein sequence ID" value="SLM46651"/>
        <property type="gene ID" value="NSJP_0479"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0479"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="95"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="419" mass="46342" checksum="0D93A3041EE7CF96" modified="2017-06-07" version="1">MEGEISNLRTPASGHVYCTLKDERSQIRAVLFRSSAVRIRFALQDGMHVIVRGRLSVYEPRGEYQILMEAVEPKGVGALQVAFDQLRTRLSAEGLFDALRKKQIPRFPRTVGVVTSLNGAALKDILSVLGRRWPTLHVIVVPVQVQGEPAAQQIIEALTLLNAQRSVEVIILGRGGGSLEDLWTFNEEAVVRAVAASRIPIVSAVGHEIDMTLTDAAADLRAPTPSVAAEMVVPVLSEVLEGLRGLTVRLQMAMARHCLSEHRRLDFNSKGLSCIQFRLREKAQQVDDMTDCLIEKVRSRAGVEGDRVRQADRELSKLSPFVIVKRHLVMIPLLFKRLQRQTSVMAAQRRRRIEATCARLNSLSPLAVLGRGYGLLTKISDGSVLKRAQDARVGEAVAVRLMDGKLHCLVKDVLPDRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I115</accession>
    <name>A0A1W1I115_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0524"/>
    <dbReference type="EnsemblBacteria" id="SLM46696">
        <property type="protein sequence ID" value="SLM46696"/>
        <property type="gene ID" value="NSJP_0524"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0524"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012438734" evidence="2">
        <location>
            <begin position="24"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="495" mass="54537" checksum="C842803F3CA74146" modified="2017-06-07" version="1">MSVRCLLALVLTLALFGRLPAFAASEFPVSDRTLPPIPLSVDEVHAWIDRSHPLLKGAGTEKVMARGKMLKALGAFEPVLINDTELERFISSSNPGLGTQSKGYNDTLIEARHPWGFRGSAGIREVINGPANIPDLGFGGGTGQVILGGFFPLLKGLMINPDSAELQRSELADPRADIKIAQTRQDLFLAAATQFWDWVAAVRFVELQRKAVGVAEGRFKQIEGRAKAGAVAPLDVVEANQEVQRRREVAIGAQRLVEQEQLKLSMFLWDNGAPSAPTMERAPGFPSQMLIPNPEDVKVHKLQAKSERPEVKEIGIEAKLNNIDLELAKNNLLPSLDAEAAPARQPEKFVLGLGYRFGIELKMPILQRKGRGEVLEAQGKADRFVLTQRFREQQVVIDVDNALSAIERAKERISLAVESLRLAKAVEEGERFRFSLGATSVLFVNLRERNSVDSEAQVIRAKADYQKALALYQWAIGTWGKSDPSAIPVNYRSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I174</accession>
    <name>A0A1W1I174_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WHy domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0447"/>
    <dbReference type="EnsemblBacteria" id="SLM46619">
        <property type="protein sequence ID" value="SLM46619"/>
        <property type="gene ID" value="NSJP_0447"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0447"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009269">
        <property type="term" value="P:response to desiccation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004864">
        <property type="entry name" value="LEA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013990">
        <property type="entry name" value="WHy-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03168">
        <property type="entry name" value="LEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00769">
        <property type="entry name" value="WHy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHy" evidence="1">
        <location>
            <begin position="34"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="168" mass="18573" checksum="80A9BEE70C58D30B" modified="2017-06-07" version="1">MINKRSRWPVFWLIASMLVWGCATVPSDMEPPKVSIANIAPKDFALFEQRFDVQLRIQNPNDKELGINGLRCDIELNGKEFGNGMSGERVKIPRFGSEVVNVEVITSLGSLLRQVENLGQAGNAANPDGNKFVYRLKGTAFVESPSSFKLPFDEKGEIDLPLGSAPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1C7</accession>
    <name>A0A1W1I1C7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Low molecular weight protein-tyrosine-phosphatase Wzb (Modular protein)</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46816">
        <property type="protein sequence ID" value="SLM46816"/>
        <property type="gene ID" value="NSJP_0644"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0644"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="3">
        <location>
            <begin position="68"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="228" mass="25566" checksum="218195D433A6241D" modified="2017-06-07" version="1">MILIEHLEPTQTPIRYLIHKVANLALIVPLQRLTSLIHILRAKVFRKFAPRTWNLEDTMIANRHGSVQNLFFVCKGNICRSPLAEAYVKSKIKGKNHLRVFSAGLSTTPGHAANALAEAIARQYGLTLDQHRTTPVSREMIQEADLIVVMDYSQRQGLLAMYPEAHGKVVLLSSFSRGIVTHIPDPYGGTIERFDDCYHLISRSCDNLLNYIASLKSPLRGHPAGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1D4</accession>
    <name>A0A1W1I1D4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="2">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fhs</name>
        <name evidence="7" type="ORF">NSJP_0471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0471"/>
    <dbReference type="EnsemblBacteria" id="SLM46643">
        <property type="protein sequence ID" value="SLM46643"/>
        <property type="gene ID" value="NSJP_0471"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0471"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="482" mass="50576" checksum="A2914FA1DF053E12" modified="2017-06-07" version="1">MGLCRLGHRAIVTLREPSLGPVFGIKGGGTGGGRAQVVPMEQINLHFTGDAHAVSAAHNLLSAFVDNHVFHGNERHIDPERISWPRTSGISDRALRELMLGTGIQGQKGQFVISEASEVMAILALATGRDDLRHRLGRVIVGLTKDGKPVTSGDLNCVGSMAALLNDALLPNVVQTLEGTPAFVHTGPFGNIAHGNCSVLSDAIALRCADYVVTEAGFGSELGAEKFFNIKCRVSGHKPSAAVVVATLRALKLHGTGEGIKSGQPLPSSLTGPNMQALEKGFANLEQHIANVKRYGVPVVVAVNAFSDDSHAELEWVRERAKSAGATDAAVSTHWSDGGKGAEALAHAVIAAASQPSSFSHLYELTWPIKKKIETIAMAMYGAGAVSYDPSAERQIGVVGDLGYGQLPICMAKTPLSLSHDPSLKGRPTGFTLPIKELRLLAGAEFLTAVCSGIQLMPGLPKKPAGERIDVDGKTGTIVGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1E5</accession>
    <name>A0A1W1I1E5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease Y</fullName>
            <shortName evidence="5">RNase Y</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rny</name>
        <name evidence="8" type="ORF">NSJP_0481</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endoribonuclease that initiates mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase Y family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0481"/>
    <dbReference type="EnsemblBacteria" id="SLM46653">
        <property type="protein sequence ID" value="SLM46653"/>
        <property type="gene ID" value="NSJP_0481"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0481"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00335">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017705">
        <property type="entry name" value="Ribonuclease_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022711">
        <property type="entry name" value="RNase_Y_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF15">
        <property type="entry name" value="PTHR12826:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12072">
        <property type="entry name" value="RNase_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03319">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="7">
        <location>
            <begin position="338"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="35"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="135"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="522" mass="58484" checksum="84C231B1AC0A0B18" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1M4</accession>
    <name>A0A1W1I1M4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alginate_exp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0709"/>
    <dbReference type="EnsemblBacteria" id="SLM46881">
        <property type="protein sequence ID" value="SLM46881"/>
        <property type="gene ID" value="NSJP_0709"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0709"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025388">
        <property type="entry name" value="Alginate_export_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13372">
        <property type="entry name" value="Alginate_exp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alginate_exp" evidence="1">
        <location>
            <begin position="307"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="566" mass="61783" checksum="4E5CB365EE47C437" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1T3</accession>
    <name>A0A1W1I1T3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0783"/>
    <dbReference type="EnsemblBacteria" id="SLM46955">
        <property type="protein sequence ID" value="SLM46955"/>
        <property type="gene ID" value="NSJP_0783"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0783"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="360" mass="38003" checksum="B1D293AA3220E1F4" modified="2017-06-07" version="1">MADAVAEQIAALKDEDWAIREEAAAMLGTLRDPRAVAPLVLMLQDSDRAVREAAIGSLTAIGAPSVPALGLCLSDSHLAVQEAASAVLACIADERVLAQLLAALGNKDWIVRMHAAKALGRIKNSEAVEPLIPLLQDKVKAVREETTAALVAIGDAAIPSLLTALADADWLVRLHAVEALGKMKSSAAVEPLLSALFNDRDAAVREDIVRALGQIGDGRAVEFLMLAMKEPGLRLLAVEALGQIGDQRAVPVLIKVLEGSDQPPDSRVIAGCGDNWSEEMVTMAAAARALGALGDEAAIPSLIRALRHTITRADAAGSLAYFGSKVIAPLLTMLSQETDENLRFHVNETLTKVGWRPGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1U7</accession>
    <name>A0A1W1I1U7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endonuclease III</fullName>
            <ecNumber evidence="6">4.2.99.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nth</name>
        <name evidence="6" type="ORF">NSJP_0795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.99.18" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0795"/>
    <dbReference type="EnsemblBacteria" id="SLM46967">
        <property type="protein sequence ID" value="SLM46967"/>
        <property type="gene ID" value="NSJP_0795"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0795"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="5">
        <location>
            <begin position="45"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="219" mass="24830" checksum="CE3E2BC6E80BF933" modified="2017-06-07" version="1">MRQDQIHEAIALVRREVRQWQEPVVGVVARESDRDPFRILISCLLSLRTKDKTTGEASGRLFALAHTPAAMLSLPLAKIQQAIYPVGFYRTKAKSIRLICRRLIDVYGGTVPDSIDELLTLSGVGRKTANLVVTVGYRKPGICVDIHVHRIANRWGYVKTRTPEETEQALRHKLPKPYWITLNDLLVPYGQNLCQPMSPFCSRCKLTDYCDRTGVTKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1V0</accession>
    <name>A0A1W1I1V0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative xylanase/chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46839">
        <property type="protein sequence ID" value="SLM46839"/>
        <property type="gene ID" value="NSJP_0667"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0667"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="7"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="252" mass="28282" checksum="1F363C412EB2FAA7" modified="2017-06-07" version="1">MTSGCHARFLVTFDDGPHPNTAAILMQLSHNPIQQNIKAMFFVQTRNPAGGNSSLGRSLLDRECAEGHVLGLHTGTAGHVSHTALSEHELDQSLRNGMDDIRVITRSETMFVRPPYWRFNPDTLTGYSRHGLHMLLSDVKAYDGIDWGLHVFRQWTFHLQLEGIRRRLLRRELPTVDGMIPIVVTFHDTNNYTAGHLSEYFDLLIAESDRVGLQLDSKPFYDCASDITLAALPRTVHPVEAIEAESQPAEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I206</accession>
    <name>A0A1W1I206_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Type IV pilus assembly protein PilX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46899">
        <property type="protein sequence ID" value="SLM46899"/>
        <property type="gene ID" value="NSJP_0727"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0727"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="210" mass="21524" checksum="D08C34A46759373C" modified="2017-06-07" version="1">MPVDETNGHMVRNEHGVAFLMVMILMLILTVLGIAAMTVTGLENRIAGFQRTTEVAADAAESCLSSSVKIIQQTIENGSVPAAVVSSSGPVPTGAETAANPSLSMEINGQADNHADTVTGSGASGPDYSQTINGYTVRGDIDRLYLQAKAGSGMQFAAGYEGAGSGSAGGGVDVLYRVDCRATLAATGTESRIVGVYACTLTGETCQRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I221</accession>
    <name>A0A1W1I221_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0888"/>
    <dbReference type="EnsemblBacteria" id="SLM47060">
        <property type="protein sequence ID" value="SLM47060"/>
        <property type="gene ID" value="NSJP_0888"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0888"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011486">
        <property type="entry name" value="BBP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07642">
        <property type="entry name" value="BBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012935622" evidence="1">
        <location>
            <begin position="24"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="389" mass="43677" checksum="3D4ADE79752FC8C9" modified="2017-06-07" version="1">MNRSLLRTFGLAVWLGASVIAVSASGEETPAEPSAEPARVDKPLWHYGGFIDLGYSLDFNFPANHFFRDRSTTPRVNELNLNMVAGYVRKDATESSRWGTEWLVQAGEDSKAFGFAVGVPNAPNSDVWRHFGRANASYLAPVGNGLTVQAGLFNSFIGYESLYAKDNGNYTRAWIADYSPYLMFGVNAQYDFNERWGGAFFIINDYFHLEHSNNVPSYGGQVRYTPASGWTVKETVYYGPDQSDTAMEFWRFFSDSIVEWKGEHLTLAFDYQIGTQRNASAPGNPRDFYTGGTLETRWHIAGPWAVSVRPEFYWDRNGLMTGSEQFIKAVTTTGEYRIPYKWTTTICRLEYRYDDSTGPGGGFFKGTNNVLTPGQQMLIFSVVGTFDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I257</accession>
    <name>A0A1W1I257_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Peptidase M16</fullName>
            <ecNumber evidence="4">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0903</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.24.-" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0903"/>
    <dbReference type="EnsemblBacteria" id="SLM47075">
        <property type="protein sequence ID" value="SLM47075"/>
        <property type="gene ID" value="NSJP_0903"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0903"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="173"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="280"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="541" mass="59064" checksum="082FC7BCC79ECEB5" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I269</accession>
    <name>A0A1W1I269_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0787"/>
    <dbReference type="EnsemblBacteria" id="SLM46959">
        <property type="protein sequence ID" value="SLM46959"/>
        <property type="gene ID" value="NSJP_0787"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0787"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="375" mass="41608" checksum="BE68129DB93A0C8D" modified="2017-06-07" version="1">MKKAEPPASRRQNRRLAFLKIRVLRYHFFLNFGGETRTMWYSRIVLIGVALALFVLETASATSKSSRTSPVPVTPPSAPLTEHVILFVLEGFSHRSLAGGTMPTLSRLVKEGSVTWSATSVKPALRLPTMASLITGMPVEKHGITWNVFEFSRGYPRAPSVFDYLDLSGGRDSAIFFMDEALYQLARPEPYTDYQMCGPLKPECNPDRVVSYIRQYFKKATSGHGYGHAILSLPHFLVVHLPEAGRVGAARGWESKEYREALRVVDKAMTSVLDLYKEEGLLKRTTIFVTSLSEEGRDANQKEADGVTPVVPWIASGVGIKQGHAIHQPVSIIDTGATVMRSLGLETHTEWESRSVEEIFQSAFVPAEPNSTIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I280</accession>
    <name>A0A1W1I280_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Ribonuclease inhibitor Barstar (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the barstar family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0909"/>
    <dbReference type="EnsemblBacteria" id="SLM47081">
        <property type="protein sequence ID" value="SLM47081"/>
        <property type="gene ID" value="NSJP_0909"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0909"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000468">
        <property type="entry name" value="Barstar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035905">
        <property type="entry name" value="Barstar-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01337">
        <property type="entry name" value="Barstar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52038">
        <property type="entry name" value="SSF52038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Barstar" evidence="2">
        <location>
            <begin position="45"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="179" mass="19716" checksum="36F0E44CC2FA244A" modified="2017-06-07" version="1">MPHRTSLASIIQSIKAPWVLLLTLDAGAHIEKVFHVPDGFVLRVVRGAKCRTAAALFQEFARALKLPDYFGHNWDALEECLADLEWLPAKGYVLAVTEAEQVLIKEEDDYSTFLEVLSDAGEAWAAGQAGSGSRPFHVILTVSHQQRAARAHWSIPEVGLDAEVGHRAKVSRKQPPSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I288</accession>
    <name>A0A1W1I288_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Polynucleotide phosphorylase</fullName>
            <shortName evidence="6">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">pnp</name>
        <name evidence="9" type="ORF">NSJP_0761</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0761"/>
    <dbReference type="EnsemblBacteria" id="SLM46933">
        <property type="protein sequence ID" value="SLM46933"/>
        <property type="gene ID" value="NSJP_0761"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0761"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="621"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="686"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="706" mass="76059" checksum="3ACBDBACED965EB6" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2F8</accession>
    <name>A0A1W1I2F8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Coenzyme PQQ synthesis protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1024"/>
    <dbReference type="EnsemblBacteria" id="SLM47196">
        <property type="protein sequence ID" value="SLM47196"/>
        <property type="gene ID" value="NSJP_1024"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1024"/>
    <dbReference type="UniPathway" id="UPA00539"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018189">
        <property type="term" value="P:pyrroloquinoline quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022479">
        <property type="entry name" value="PqqD_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03859">
        <property type="entry name" value="PQQ_PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0884">PQQ biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="93" mass="10348" checksum="D8AFDE7049FFB573" modified="2017-06-07" version="1">MPDSLVRPRLNPKVRLRLDRHTGRYLLLYPEAGLDLNDTGSGILRRCTGEYTTEDIISELAAVHAGTSRSEIARDVRAFVRTLADRGLIQDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2J4</accession>
    <name>A0A1W1I2J4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Oxidoreductase, NmrA-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1045"/>
    <dbReference type="EnsemblBacteria" id="SLM47217">
        <property type="protein sequence ID" value="SLM47217"/>
        <property type="gene ID" value="NSJP_1045"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1045"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="316" mass="34343" checksum="756328483119D635" modified="2017-06-07" version="1">MAEKKIIAVVGATGAQGGGLVHAIANDPASDLKVRALTRSTQGDKAKALAEMGVDVVQADLDDLESLKRAFAGAYGVFGVTNFWEHLSPERELKQAASQAEAAKVAGVRHVIWSTLEDTRRWVPLSDSRMPTLMGKYKVPHFDAKGEADREFSSRGVPTTFLLTSFYWDNLIFLGMGPKKGPDGVLQFSLPMGNAKLPGIAAEDIGKCALGIFKKGEEYIGKTVAVAGELLSGPEMARAMTETFKQPVRYQDMTPEAYRALGFPGADDLGNMFQFKRDFNEAFCGPRNPSVARALNPALQSFATWLSRNKSRIPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2N9</accession>
    <name>A0A1W1I2N9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ackA</name>
        <name evidence="8" type="ORF">NSJP_1098</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1098"/>
    <dbReference type="EnsemblBacteria" id="SLM47270">
        <property type="protein sequence ID" value="SLM47270"/>
        <property type="gene ID" value="NSJP_1098"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1098"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="213"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="288"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="335"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="401" mass="43482" checksum="049960FE78042D16" modified="2017-06-07" version="1">MAQTAFGPGPFILTVNGGSSSLKVALFRDENPPVSMVRCLFSRIGFPDSLMTVVSGTTKKPESRTLAVPDHAAGMDLLMHWLEQAVGLGNIRAVGHRVVHGGVTYSRPERVTPDMLAELRRISPYDPEHLPSEISLIEAVGRRCPGLFQAACFDTAFHHDLPRVAALLPIPRRYDAQGLRRYGFHGLSCAFLMRELTRVGKTGEADGRIILAHLGNGASMTAVRRGRSIETTMGFTPTSGLPMSRRSGDLDPGIIAYLARTEGMDVERFHRMVNAESGLLGVSELSPDMRDLLAQEARDPRAAEAVALFCYHARKAVGALAATLGGLDTLVFSGGIGEHAAPVRARICESMEFLGITIDPRRNQAGEPVLSRQDGQVTVRLIPTDEETEIARSVHELLGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Q2</accession>
    <name>A0A1W1I2Q2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M41 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1100"/>
    <dbReference type="EnsemblBacteria" id="SLM47272">
        <property type="protein sequence ID" value="SLM47272"/>
        <property type="gene ID" value="NSJP_1100"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1100"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M41" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="89" mass="10204" checksum="B04A2F42F37C69E1" modified="2017-06-07" version="1">MSEKIGTVTLEQERRPQFMQIQAPAEKGEYSEKIAREIDCEVRRIIDEQYARVKRLLAGTRSALHEGARLLLEQEVMTGEDLKAIMDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I321</accession>
    <name>A0A1W1I321_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1107"/>
    <dbReference type="EnsemblBacteria" id="SLM47279">
        <property type="protein sequence ID" value="SLM47279"/>
        <property type="gene ID" value="NSJP_1107"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1107"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010980">
        <property type="entry name" value="Cyt_c/b562"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47175">
        <property type="entry name" value="SSF47175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="157" mass="17068" checksum="134085D173665B29" modified="2017-06-07" version="1">MKLSIGTVSLALWTATIAAGMWFFVVGWTKPGTDGRTEIFLGADERDLVLGEMRHLLKAVHGIVTGLGGQDQPADRQQIEQAARAAGMGLAADVNPALMEKLPLAFKQIGMSIHRDMDALADAVAQKENSQQILQRLSSMTARCTTCHDMFKFSVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I361</accession>
    <name>A0A1W1I361_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47401">
        <property type="protein sequence ID" value="SLM47401"/>
        <property type="gene ID" value="NSJP_1229"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1229"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="109" mass="11658" checksum="54BCF862FC339A58" modified="2017-06-07" version="1">MSAQASPNDFRSSRKDLPVHEDEGESRHSAEAAVGRHRQLQLLPRECAPGDLCGTREEVCDRGGLSGAANVDYGARLDMPVYEPGRGVGGLRSPSTVSEQTHPTRSGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I371</accession>
    <name>A0A1W1I371_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1284"/>
    <dbReference type="EnsemblBacteria" id="SLM47456">
        <property type="protein sequence ID" value="SLM47456"/>
        <property type="gene ID" value="NSJP_1284"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1284"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="168" mass="18858" checksum="D26BAC448E538D30" modified="2017-06-07" version="1">MAKAKGVILVGHGGIPKDCPQELVTKLKRLEGQRRAAHAPPSPEELELDKKIRHWPRTDVTDSYQAGLESVARQLRTRLKDVWFAVAYNEFCTPTLEEAVNDLVARGAEQIIVATTMFTPGGSHSEIEIPEILDRLRLEHPTVVLRYAWPFDLSAVADLLHGQVERFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3A2</accession>
    <name>A0A1W1I3A2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetylmuramoyl-L-alanine amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47441">
        <property type="protein sequence ID" value="SLM47441"/>
        <property type="gene ID" value="NSJP_1269"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1269"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="750" mass="83450" checksum="617CFAF94BF55887" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3D6</accession>
    <name>A0A1W1I3D6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47520">
        <property type="protein sequence ID" value="SLM47520"/>
        <property type="gene ID" value="NSJP_1348"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1348"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012732205" evidence="1">
        <location>
            <begin position="24"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="110" mass="11929" checksum="90E6DE32FCF644B8" modified="2017-06-07" version="1">MKTTARAMGALLLLALAACTANKQTVDANGDYIAPASIYSVMDSTSLVYTDVAAGAPLNDHPLRWTAFVLHPVGQVLDYGINRPFYAVPSQAPYLFGYTSEDSMLDNQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3H0</accession>
    <name>A0A1W1I3H0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47534">
        <property type="protein sequence ID" value="SLM47534"/>
        <property type="gene ID" value="NSJP_1362"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1362"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="99" mass="11458" checksum="179DB1946135FE14" modified="2017-06-07" version="1">MFNSLLLQFRQTVNDAQPDFVTHLHLHHLGGQTAPHAQRVFHLELHLPSAEFDKMKEQQGGQALQFVVAGVFAEIQNLGHDRRPRSRRFLSLFYRPNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Q3</accession>
    <name>A0A1W1I3Q3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1458"/>
    <dbReference type="EnsemblBacteria" id="SLM47630">
        <property type="protein sequence ID" value="SLM47630"/>
        <property type="gene ID" value="NSJP_1458"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1458"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_8" evidence="1">
        <location>
            <begin position="142"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="196" mass="21442" checksum="F35C00342DBB3CD6" modified="2017-06-07" version="1">MTLSPSAFSVLLLSSDADIQTQFRQAFKDASVTTVRDAAALSKDSAKRIFDAVILEAKPGTHGVVPALPGHLDLTQALIITGTRSALRRVSKFMQTLNRSKHAAANGQAAPSLEDFIERKMGDFVKGMRNGSGRNLHPMLISAIERPLITRALQETKGNQIQAAELLGLNRNTLRKKIQELHIPVKRGRPARMRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3V7</accession>
    <name>A0A1W1I3V7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative HTH-type transcriptional regulator, rrf2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1459"/>
    <dbReference type="EnsemblBacteria" id="SLM47631">
        <property type="protein sequence ID" value="SLM47631"/>
        <property type="gene ID" value="NSJP_1459"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1459"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="149" mass="16419" checksum="1558274D05AAF1F9" modified="2017-06-07" version="1">MKVSLRSTYGIMAAVDLAMHSGLLPVQAKSIAKRQGIPARFLEQVLHAMKKAGLVSSQRGAQGGYVLSKKPTELSIAEVLEALDGPFLTGNGSNGRPPFQRMTKSELLLAKVWERVQEAERHVLEAITIDELAGKQRVLDQQRTLMYHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3X2</accession>
    <name>A0A1W1I3X2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable transaldolase</fullName>
            <ecNumber evidence="2">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">tal</name>
        <name evidence="3" type="ORF">NSJP_1536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 3B subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1536"/>
    <dbReference type="EnsemblBacteria" id="SLM47708">
        <property type="protein sequence ID" value="SLM47708"/>
        <property type="gene ID" value="NSJP_1536"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1536"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00956">
        <property type="entry name" value="Transaldolase_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00494">
        <property type="entry name" value="Transaldolase_3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022999">
        <property type="entry name" value="Transaldolase_3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033919">
        <property type="entry name" value="TSA/FSA_arc/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0704">Schiff base</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="216" mass="23722" checksum="113EC135A35D1C35" modified="2017-06-07" version="1">MKFYLDTASVKEIQEAASLGLLDGVTTNPSLVAKEGRVFREVLVEICNIVDGPISAEVVSIEADAMVKEGRELAKIHKNIVVKIPLIAEGLKATKRLTAEGIRVNVTLCFSPTQALLAAKAGAWCVSPFIGRLDDISSNGMELIRQIITIYKNYDYKTYVLVASVRHPQHVVEAALAGGHICTMPFTIFQQMVKHPLTDAGLKKFLADWESQNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I457</accession>
    <name>A0A1W1I457_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47755">
        <property type="protein sequence ID" value="SLM47755"/>
        <property type="gene ID" value="NSJP_1583"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1583"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="44" mass="4851" checksum="2D9E7714B8C3DF2A" modified="2017-06-07" version="1">MLTQGKGHFKRLEAFPRADTAIQPARRGLSTETGFHLPSEAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4C2</accession>
    <name>A0A1W1I4C2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47858">
        <property type="protein sequence ID" value="SLM47858"/>
        <property type="gene ID" value="NSJP_1686"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1686"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="65" mass="6918" checksum="ACEE21D6D077C7E3" modified="2017-06-07" version="1">MRIRGCPAAVSENDSTITHWPSGREAVESRNPATAEALASPKTCQHPVTERQPKPVRPGSLEGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4F0</accession>
    <name>A0A1W1I4F0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Sugar nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1716"/>
    <dbReference type="EnsemblBacteria" id="SLM47888">
        <property type="protein sequence ID" value="SLM47888"/>
        <property type="gene ID" value="NSJP_1716"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1716"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="239" mass="26820" checksum="4978C49DD5F0AE3E" modified="2017-06-07" version="1">MKAVILAAGVGKRLWSVTQHRPKCLIEIGGRSLLHRYLQSLGAVGVSRADIVVGYKQELIRSAVDADSCGIRVNFLVNEQFHRGSISSLWVARAVLDDDVIIMDADVLFHREILRRLVNSAYPNALLMDESVKQTGEECMVVIEGGRVIALTKRMPLHYDYAGEGVGFLKVRAADTPHIVASLKTYVDREAWQMEYEDALSEFFKDVKVGHEKIGGLPWTEIDFIEDVERAERDVLPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4G9</accession>
    <name>A0A1W1I4G9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative DNA recombination protein RmuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_1541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RmuC family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1541"/>
    <dbReference type="EnsemblBacteria" id="SLM47713">
        <property type="protein sequence ID" value="SLM47713"/>
        <property type="gene ID" value="NSJP_1541"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1541"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003798">
        <property type="entry name" value="DNA_recombination_RmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30563">
        <property type="entry name" value="PTHR30563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02646">
        <property type="entry name" value="RmuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="462" mass="51275" checksum="615B502CA4B5A79B" modified="2017-06-07" version="1">MIESIPFSLGLAVGAVVGSVIAWLAVSAKLRSVFHGQLTSISERAQRAETLSEELRRQRETEQTEHGRLRQEFQDMSRSCAIAETRAAEAFRHAEEQKTLLSQARQELADSFRALSGEALKHNNEAFLSLAKATYETLQTEAKGDLAQRQQAIDELVRPLTESLHRYDEQLRAMEQSRQAAYGGLDQHMKLLAESQQRLKEETGNLVNALRAPAVRGRWGEITLKRVVELAGMVAHCDFTEQESVAVEDGRLRPDMIVQLPGGRQIVVDAKAALNGYLDAYEASGEDQRREGLRRHAAQVRTHMGQLSLKAYWSQFAQAPEFVVLFLPGEQFLGAALEQDPGLIEDGFAQGVVLATPTTLMALLRAVAYGWRQERLTAHAEEAGRLGKDLYERMAVLAEHLNDVGQALGRSVTAYNKAVGSLETRILPAARRFKELGVASDKDIPLLGPMEIVPRRTLPHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4L2</accession>
    <name>A0A1W1I4L2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2 3">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">proC</name>
        <name evidence="6" type="ORF">NSJP_1743</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2 3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1743"/>
    <dbReference type="EnsemblBacteria" id="SLM47915">
        <property type="protein sequence ID" value="SLM47915"/>
        <property type="gene ID" value="NSJP_1743"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1743"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="4">
        <location>
            <begin position="8"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="5">
        <location>
            <begin position="164"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="270" mass="28152" checksum="81B5F22731C0CB3B" modified="2017-06-07" version="1">MPDPVISVGFVGGGQMAEAIVGGMLGAKLCSPQGLWATDPVAARRDQLKTLFGIRVGEDNRALTEWADLVILAVKPQVLPGVLKEIGSFLAGKLVVSIVAGLPIRVIAERAPGVRGIIRAMPNQPVFVREGMTALTGGHAAPAADLSFVRAMFEAVGRVVEVDERLMDAVTGLSGSGPAYVFQAIEALADGGVKMGLPRRTADLLAAQTVFGAARMVLESREHPASLKDRVASPGGTTIAGLHRLEQGGFRATLMGAVEAATKRSEELGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4U4</accession>
    <name>A0A1W1I4U4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48047">
        <property type="protein sequence ID" value="SLM48047"/>
        <property type="gene ID" value="NSJP_1875"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1875"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="126" mass="14026" checksum="2CDF29854963A282" modified="2017-06-07" version="1">MRPRETTYSLLMRGLSIWTILFLLIIAPLAVAQEVHHELAAADTDGHEHSDNDLCQWVQHQSSASINLNTLIFSIWEIVRQGDLLPQRIPFSAQSGLLGPSRAPPRFNVPTQSHAVIGESHRLANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I578</accession>
    <name>A0A1W1I578_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47983">
        <property type="protein sequence ID" value="SLM47983"/>
        <property type="gene ID" value="NSJP_1811"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1811"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="124"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="276" mass="30157" checksum="F955579BF0429664" modified="2017-06-07" version="1">MHRAPRRSRTLIRIQAEFQGISEDASIKGKGYTLDLNINGCRIESNTSVPRGSYIRLRLAIPKAPHPVEIGMARVRWVQTGSFGVEFIQRSAEDLPYISRATTESSREVTVQALQPKSGKAPCTVLVVEDDPDVLHLCAKTLEGVDCKVLKASGSSEALQICSTHSGAIHLLLVDLVLRPPVLQLMSGHEQYPRVHGSDLIEHILRIRKKCHVVFMSGHDETALRALGIEVGGALCLQKPFSREDLLMAINQAMAGPPMVSKAPHSGAVKRAVNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5D9</accession>
    <name>A0A1W1I5D9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48210">
        <property type="protein sequence ID" value="SLM48210"/>
        <property type="gene ID" value="NSJP_2038"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2038"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="23" mass="2500" checksum="BBE54A51D5D89A0E" modified="2017-06-07" version="1">MLILGYFFVGILMQRLLTISGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5P3</accession>
    <name>A0A1W1I5P3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_2154</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2154"/>
    <dbReference type="EnsemblBacteria" id="SLM48326">
        <property type="protein sequence ID" value="SLM48326"/>
        <property type="gene ID" value="NSJP_2154"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2154"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019283">
        <property type="entry name" value="DUF2330"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004338">
        <property type="entry name" value="NqrB/RnfD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011303">
        <property type="entry name" value="RnfD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30578">
        <property type="entry name" value="PTHR30578"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30578:SF0">
        <property type="entry name" value="PTHR30578:SF0"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10092">
        <property type="entry name" value="DUF2330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03116">
        <property type="entry name" value="NQR2_RnfD_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="736" mass="82097" checksum="12CADF470C183F5A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5R4</accession>
    <name>A0A1W1I5R4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48325">
        <property type="protein sequence ID" value="SLM48325"/>
        <property type="gene ID" value="NSJP_2153"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2153"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="13"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="224"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="280" mass="30441" checksum="2FBA40D29030BD17" modified="2017-06-07" version="1">MMSNESPQSGLSFRQIFHPTDRAAREQAAFAHALKLTCLAQANLTIMHVGPEDFDDFPRVRPMLQKWGLLPEGSAKEDVTRLGMHISKVRALADHAAAAILRQLTLQPADLLVMSTHQREGLARLTHEAVAEPVARGAHVKTLFVPAGIEGFVSAQTGAVKLERILVPVARHPDPQPAIDAAVELAGALGAEKVLFELVYLGDETTFPKINKPAQPGWRWERLIAKGHAVDWIVAAGQDFDVDLIVMTTAGHHSVIDMLRGSTTERVLRAARSPLLAIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5S2</accession>
    <name>A0A1W1I5S2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Epoxyqueuosine reductase</fullName>
            <ecNumber evidence="7">1.17.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Queuosine biosynthesis protein QueG</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">queG</name>
        <name evidence="9" type="ORF">NSJP_2119</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:32159"/>
            <dbReference type="Rhea" id="RHEA-COMP:10345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82831"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="1.17.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 2 [4Fe-4S] clusters per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the QueG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.17.99.6" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2119"/>
    <dbReference type="EnsemblBacteria" id="SLM48291">
        <property type="protein sequence ID" value="SLM48291"/>
        <property type="gene ID" value="NSJP_2119"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2119"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052693">
        <property type="term" value="F:epoxyqueuosine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
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        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
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        <property type="entry name" value="QueG"/>
    </dbReference>
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        <property type="entry name" value="QueG_DUF1730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30002">
        <property type="entry name" value="PTHR30002"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1730"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TIGR00276"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cob(II)alamin binding" evidence="7">
        <location>
            <begin position="241"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="326" mass="36132" checksum="2ACEBDDFF5C3DEA8" modified="2017-06-07" version="1">MSLSAVIRQEAIALGFDAVGISSVAQSHSTTLLDRLEEWLARRYHGTMAWLARDPSRRADPTVVLPNCRSIVSVGLNYDTGHRATEGPGFGRIARYAWGRDYHRTLGDRLTLLENRIKALAPTAATRTYVDTGPVMEKAWAQQAGLGWIGKHSNLVSAQYGSWLLLGEVLTTLELTPDEPATDLCGNCRLCIQACPTGAIVEPYVVDARRCISYLTIEFRGAADMIEHEIRQQMGNHIFGCDDCLDVCPYNLQAEEKAVTAFSPAPLSLAPRLSELAELTDETFTERFRDSPIRRTKRDGLLRNVTIAQHNETRHTKNSPLLSPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5V4</accession>
    <name>A0A1W1I5V4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Nitrate oxidoreductase, alpha subunit</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nxrA</name>
        <name evidence="6" type="ORF">NSJP_2214</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.4" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2214"/>
    <dbReference type="EnsemblBacteria" id="SLM48386">
        <property type="protein sequence ID" value="SLM48386"/>
        <property type="gene ID" value="NSJP_2214"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2214"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1145" mass="131639" checksum="3175D49A88DDA0B1" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5V5</accession>
    <name>A0A1W1I5V5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48392">
        <property type="protein sequence ID" value="SLM48392"/>
        <property type="gene ID" value="NSJP_2220"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2220"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="58" mass="6441" checksum="78ECE4A21986A3F6" modified="2017-06-07" version="1">MTDKGSIATGMAKDTIREIKEWQAIMDHLRNLPVKNPGELPVIQVDERAVEVRAINAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I612</accession>
    <name>A0A1W1I612_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sigA</name>
        <name evidence="9" type="ORF">NSJP_2275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2275"/>
    <dbReference type="EnsemblBacteria" id="SLM48447">
        <property type="protein sequence ID" value="SLM48447"/>
        <property type="gene ID" value="NSJP_2275"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2275"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="319" mass="36926" checksum="B18DFB8376F756A4" modified="2017-06-07" version="1">MAREQDNFENESEARRHHVERDEEFADREEGGDGEEEKRGRRSEGLDTLKSYLREIRRSSLLTFKQEQQLGKRVMAGDEQARQQMIESNLRLVISIGKRYMHRGFPFSDIVEEGNIGLIKAVEKFNYKRGFRFSTYASWWIRQYIERAIINQGKLVRLPVHVVERLNRYLNRSEALVQTLGREPTAAEVAVRLKTTEEEVLDLKQVIRTTCSLDSPINDQADTFLRDVIEDPSCPSPADTAEGVLRRAEMMAWVKELPEKEQTVIVSRFGLDGSEAKTLEEIGTEMGLTRERVRQIEMAALSRLRHTIERKTLTQSDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I632</accession>
    <name>A0A1W1I632_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase</fullName>
            <shortName evidence="3">GMPMT</shortName>
            <ecNumber evidence="3">2.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">(1-&gt;4)-alpha-D-glucan:maltose-1-phosphate alpha-D-maltosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">glgE</name>
        <name evidence="6" type="ORF">NSJP_2229</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1-&gt;4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate = [(1-&gt;4)-alpha-D-glucosyl](n+2) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42692"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:10183"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="EC" id="2.4.99.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.16" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2229"/>
    <dbReference type="EnsemblBacteria" id="SLM48401">
        <property type="protein sequence ID" value="SLM48401"/>
        <property type="gene ID" value="NSJP_2229"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2229"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02124">
        <property type="entry name" value="GlgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026585">
        <property type="entry name" value="GlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021828">
        <property type="entry name" value="GlgE_dom_N/S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF203">
        <property type="entry name" value="PTHR10357:SF203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11896">
        <property type="entry name" value="DUF3416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="5">
        <location>
            <begin position="203"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Maltose 1-phosphate binding" evidence="3">
        <location>
            <begin position="524"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="664" mass="77036" checksum="15FD88C11A70FEB3" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I660</accession>
    <name>A0A1W1I660_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_2141</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2141"/>
    <dbReference type="EnsemblBacteria" id="SLM48313">
        <property type="protein sequence ID" value="SLM48313"/>
        <property type="gene ID" value="NSJP_2141"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2141"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="4">
        <location>
            <begin position="44"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="5">
        <location>
            <begin position="196"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="452" mass="51143" checksum="BE2F34B6A6F6017B" modified="2017-06-07" version="1">MRRHPARRQPNPAYPASLLMKLSRGHRTLLRGLGRMADKQGVALYLVGGVVRDLLLNRNNLDLDLAVEGDGIAFARRMCRRYRTAATVFDKFATARLRMPSGLKLDVASTRRESYVHAAALPAVEPASLQEDLYRRDFTINAMAIKLNALTFGRLEDPFEGVRDLSAKRIRILHEGSFQDDPTRIFRAIRFAERFGFTIESKTGRLLAEAASTDFVARLSGPRLRNEIFLLLGEHRPSRSMEQLDRLKLLRFLHPTLRYGKAVRRVMDSLSAALAWWEGQTGKRPADIPMLRLMALLSQSGPSVIRAVAQRLQLSSAQAVALSYAEDRTARLLVELSRERILPSEVYRSLAPVPDEAFVLVAAKARVLRRSKAADRVKRRLNRYLRRDRHLRITVDGHDLATLGLKPGPQFKIILDRLLEARIDGKVRSAAEERKLASRMVLEAGKRRQSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6P9</accession>
    <name>A0A1W1I6P9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2515"/>
    <dbReference type="EnsemblBacteria" id="SLM48687">
        <property type="protein sequence ID" value="SLM48687"/>
        <property type="gene ID" value="NSJP_2515"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2515"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001893">
        <property type="entry name" value="Cys-rich_GLG1_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00839">
        <property type="entry name" value="Cys_rich_FGFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="139" mass="14889" checksum="DE7FE392FC1B0A49" modified="2017-06-07" version="1">MYRDWTTESFEGNGDGQSVTDADGKESMLERLRSETIACRVLAGCVLWAMLVVAPHGADADNQPSHEAKPAGAPEQTPTQAAGGHENLNRLKAACGEDAKRHCKGVMPGGGRILKCLHEHDSELTAECRHAMEPSPSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6T6</accession>
    <name>A0A1W1I6T6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">amtB</name>
        <name evidence="10" type="ORF">NSJP_2407</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2407"/>
    <dbReference type="EnsemblBacteria" id="SLM48579">
        <property type="protein sequence ID" value="SLM48579"/>
        <property type="gene ID" value="NSJP_2407"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2407"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="9">
        <location>
            <begin position="45"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM48579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="443" mass="45718" checksum="EEFA319FA237927B" modified="2017-06-07" version="1">MAIMIERRAAISGAVVVGAAPGILPGWAWAQSAPQASLISGADTAWVLLSAALVLTMIVPGLALFYGGLVRSKNVLGTIMQSFAILCVVSLLWVTVGYSLAFGPDVSGVIGGLEWIGLAGVGLTPHAVYGPTVPHQAFMIFQLMFAAITPALITGAFAERMKFSSVMLFSVLWSLGVYCPVAHWLWGGGWLAQLGALDFAGGAVVHVSSGISALVCALVLGARHGYGTDYMAPHNLPLVLLGTGLLWFGWFGFNAGSALGANETAVVAFVATHTAAVTGALTWTAVEWWHRGTPTVLGLASGAIAGLAMVTPGAGYVSPLSALLMGLAAGSLSYLAIMKKGRWGYDDSLDVVGIHGVSGVVGVLLTGLVASKAVNPAGADGLVFGNVAFFAAQTLTVAVVGVYSAFGTWAALKMADRLVGLRMQPDEERMGLDISQHNERAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Y0</accession>
    <name>A0A1W1I6Y0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="4">G6PD</shortName>
            <ecNumber evidence="4">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">zwf</name>
        <name evidence="7" type="ORF">NSJP_2568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2568"/>
    <dbReference type="EnsemblBacteria" id="SLM48735">
        <property type="protein sequence ID" value="SLM48735"/>
        <property type="gene ID" value="NSJP_2568"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2568"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 4" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="5">
        <location>
            <begin position="11"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="6">
        <location>
            <begin position="181"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="465" mass="52530" checksum="78798466D6ACAA3C" modified="2017-06-07" version="1">MMSDSHSDALVFFGATGDLAYKKIFPSLQSMVKRGRLDVPVIGVAKAGWTLEQFRERARESLERHGGIDPAAFAKLTALLRYVDGDYRDPATFQAIRDALKGAVRPTHYLAIPPVLFETVIEQLAKSGSDHAGRVIVEKPFGTDLKSAQLLNGILLKSFDEPAIFRIDHYLGKRPVHNLIFFRFSNAFLEPFWNREHVESVQITMAESFGIQGRGAFYDGTGTMRDVVQNHLFQVLAYLTMEPPVRIDSESVRDEKVKILRAIPTLEPIDIVRGQFRGYRNEAGVAPDSQMETFVALRLNVNSWRWQGVPFYIRAGKCLPVTCTEIVVRLRRPPTLFPTSTSEPNYFRFRISPEVTIAFGTTVMDEAEKMIGQTVEMVASHWPGTDDMDAYARVLADAMAGDPTLFAREDYVEEAWRVVDRALKARTPVYEYEPNTWGPREVDHFIAPAGGWQNPIVGRTDVERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I785</accession>
    <name>A0A1W1I785_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48882">
        <property type="protein sequence ID" value="SLM48882"/>
        <property type="gene ID" value="NSJP_2715"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2715"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="82" mass="9413" checksum="06A4F0A36AC1073E" modified="2017-06-07" version="1">MTGHVLLESSVGIGHSPDSLVREILDRVEEEAVLSLDSLVMSLPHYSWNQILIAVDRLARDGRLILRRHRFDYTLFSKHYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7F3</accession>
    <name>A0A1W1I7F3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribulose 1,5-bisphosphate carboxylase, large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2757"/>
    <dbReference type="EnsemblBacteria" id="SLM48924">
        <property type="protein sequence ID" value="SLM48924"/>
        <property type="gene ID" value="NSJP_2757"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2757"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016984">
        <property type="term" value="F:ribulose-bisphosphate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033966">
        <property type="entry name" value="RuBisCO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000685">
        <property type="entry name" value="RuBisCO_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036376">
        <property type="entry name" value="RuBisCO_lsu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036422">
        <property type="entry name" value="RuBisCO_lsu_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42704">
        <property type="entry name" value="PTHR42704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00016">
        <property type="entry name" value="RuBisCO_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51649">
        <property type="entry name" value="SSF51649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54966">
        <property type="entry name" value="SSF54966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RuBisCO_large" evidence="1">
        <location>
            <begin position="128"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="386" mass="41685" checksum="F455C2744AF33E23" modified="2017-06-07" version="1">MSVRLSAESKPPSPNARVTALYHAGGSETEARATAELICLDQTVEASDEILTAELRHRIVGRLEDFQPRPTGGYEVRISYAADLIGRHLTDLLNLLFGTSSLRPGVRLISWELPDSILPQWRGPRFGMAGLRELTGIRDRSLVCAVLKPLGRSPRELADLATEFVLGGADLIKDDQGLVDQPFCPFDERVARCADAVSTAAAKRGRPCPYLVHVSGPLDVMRTRAALAKKRGAGGLLVAPGLTGFDALRFLAEDETLALPIASHPALLGSYTIHRDHGIAPAALYGQLPRLAGADLSIYPGYRTGYAMTRDDCAALARACRTAWEHVRPMAPTAAGRIGTPDIAEFTTFYGRDVVFILGSRIQADPLGLAAATERFVRELHRCADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Q0</accession>
    <name>A0A1W1I7Q0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Outer membrane lipoprotein, Slp family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2722"/>
    <dbReference type="EnsemblBacteria" id="SLM48889">
        <property type="protein sequence ID" value="SLM48889"/>
        <property type="gene ID" value="NSJP_2722"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2722"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004658">
        <property type="entry name" value="OMP_Slp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03843">
        <property type="entry name" value="Slp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012258284" evidence="1">
        <location>
            <begin position="27"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="177" mass="19152" checksum="F8810ACEAC57BAD0" modified="2017-06-07" version="1">MKGVSVAALLLASLACVACSPSQVFAPDVMEGVDQEFDFSRWRALPNQDEGKKVELGGAILQSDVKGDTVTFVLRQLPIVKHPAYGPKDTGKRSGEFAATFSGTLEPKFLQRGNRVVVIGTTKLAKVVVVDDIPRSLPNLEVKCLHIWNTGGRDIADFPSFGAGYETLENQTWCASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7T7</accession>
    <name>A0A1W1I7T7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NapD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2910"/>
    <dbReference type="EnsemblBacteria" id="SLM49077">
        <property type="protein sequence ID" value="SLM49077"/>
        <property type="gene ID" value="NSJP_2910"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2910"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="335" mass="37578" checksum="42EACDE38E81BFC8" modified="2017-06-07" version="1">MKHAEVLMRLRAFMIVLIVFVSAGPVPAQGDPLASWNEGPVKKSLTDFVSRVTTVGGPEFVPLAERIAVFDNDGTLWAEQPIYFQLQFAFDRITALAPKHPEWKDTQPFKALIEEDKKAFLAGGEKALLEVMAVSHSGMTTEEFDATVKEWIATAKHPRFGRRYNEMVYQPMLELLAYLRANGFKPFIVSGGGVEFMRAWVEPVYGIPPEQVVGSVGKEKFELRDGRPVLVKLPAVDFVDDGQGKPVGIQKFIGRRPILAFGNSDGDHQMLQWTAAGSGARFMGLVHHTDAEREWAYDRASHIGKLDKALDEATAKEWSVVDMRRDWTRVFPFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I884</accession>
    <name>A0A1W1I884_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2964"/>
    <dbReference type="EnsemblBacteria" id="SLM49131">
        <property type="protein sequence ID" value="SLM49131"/>
        <property type="gene ID" value="NSJP_2964"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2964"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012054323" evidence="1">
        <location>
            <begin position="24"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="30"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="403"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="559" mass="59072" checksum="83F6E5674A976999" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I886</accession>
    <name>A0A1W1I886_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2846"/>
    <dbReference type="EnsemblBacteria" id="SLM49013">
        <property type="protein sequence ID" value="SLM49013"/>
        <property type="gene ID" value="NSJP_2846"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2846"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013297648" description="Ysc84 domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Ysc84" evidence="2">
        <location>
            <begin position="113"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="232" mass="24347" checksum="93B43BE374BDE177" modified="2017-06-07" version="1">MMKCVSLPVAAAMMLLFGIILQAGNASFASADETTEQQQLIDQAISTFERFLAEPGLAAGYRLKPDSMKAVFIVPKLWRGAVVVGGSGGRGVLVARDLLKGGWSPPAFYTMSSTSFGPQIGVDSSELILIVQSFAALERFSGKGTKRLGVDGGFTVGAFGEGGTTALDLISFAWSKGVFVGFSLQGFAITASAKDNQTYYGAPVNPEEILANKTVTNPGADRLRAALARLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8A9</accession>
    <name>A0A1W1I8A9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49225">
        <property type="protein sequence ID" value="SLM49225"/>
        <property type="gene ID" value="NSJP_3058"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3058"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="56" mass="6287" checksum="43E02E731894E0C1" modified="2017-06-07" version="1">MLYPLSYGRIAERYVTISHALTAAVCGYTGLYPDGSREQKPPLHSEKTLSRIHPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8D3</accession>
    <name>A0A1W1I8D3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49181">
        <property type="protein sequence ID" value="SLM49181"/>
        <property type="gene ID" value="NSJP_3014"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3014"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012958276" evidence="2">
        <location>
            <begin position="19"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="327" mass="35571" checksum="544C3F5386EF36D5" modified="2017-06-07" version="1">MTRRLCGLIASMSLTVLAAGVWPGFGPGIPGSLAQVFPPRSNTQSVPAPPQGQGGQPGGAQAPVPQAQPPHMQMPASNMPGQYQPPPPPAPLQKTVPFTTLLGGDLSKSYVQLTNLRGQMDSNFVIGRSLAGRFTLPPYIHDASNAAKVYILTNGLSNPPIVKPEGNELHLEFHFPALQLKTYYKDYSPEGDQAVGDTVGEGIIIDVFLIPVTNHQGYPTYQSARTAFRGQLKSQDKCVFWFDVIFPINICDVSKKYLATLGSAIENGMREALLHPQTRTQFDQVVWQSLRTDLLMQAGVNPMSPAQIMVLEGAFRGTDYVVKYLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8H6</accession>
    <name>A0A1W1I8H6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49348">
        <property type="protein sequence ID" value="SLM49348"/>
        <property type="gene ID" value="NSJP_3181"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3181"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="57" mass="6767" checksum="84BDA339FDAB947A" modified="2017-06-07" version="1">MWTLERWRTPFRMLCGGWGYWAASWVRFLLLPRPPLPPTHRCRGNVQTTASRLKLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8I3</accession>
    <name>A0A1W1I8I3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49231">
        <property type="protein sequence ID" value="SLM49231"/>
        <property type="gene ID" value="NSJP_3064"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3064"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="101" mass="11298" checksum="E085E55B5B8067EC" modified="2017-06-07" version="1">MAQNKREPMHRFVWHNGPASCSCGWSPPSVVTDAPRAKLRKRLREQPGLLTAAQFRSVSRALSVRTMRRDEAVMAWGVHVAGERTEGTERDMEHKGGTSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8L5</accession>
    <name>A0A1W1I8L5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative C4-dicarboxylate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3221"/>
    <dbReference type="EnsemblBacteria" id="SLM49388">
        <property type="protein sequence ID" value="SLM49388"/>
        <property type="gene ID" value="NSJP_3221"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3221"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="440" mass="46521" checksum="264A5290794FF18F" modified="2017-06-07" version="1">MTESASQNATDQDGLAPGRRRSIPLYTRVLIGALCGTALGLLLGKAPYLGPFGNEHLGLIGLAVITLLKALAIPLIFFAILDAFLRMSLPLRQGTRLLAICLINVSVAMTIGLVIMNLWNPGAAWHGHLDQLLTTDSRGAGPTRTGPGEAIEHLASYIPSTMFRPFTTNNVIGVVLLAVVSGAVLRHLRVNRPLHALERTVEIVERVYHWLIRILGWIIEVVPFAVFGVLANVVGKAGAGVFSLLWIFLVAILAGLLVHALVYYPAVAWLVGRKPPGIYIGKGADAITTALSCNSSLATVPITLRCLERMQVSPESARLAACVGTNLNNDGITLYEAMAALFLAQALGFELALGNQLLIIAASIVAGIGAAGIPEAGLVVLPLVLSAAGLPDQIITAAIPLIMTVDWILARVRSGVNVMSDMLVAILLDAAERKRLPSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8N0</accession>
    <name>A0A1W1I8N0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NSJP_3197</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3197"/>
    <dbReference type="EnsemblBacteria" id="SLM49364">
        <property type="protein sequence ID" value="SLM49364"/>
        <property type="gene ID" value="NSJP_3197"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3197"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="203"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="268"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM49364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="426" mass="47074" checksum="0751E70BE36667DA" modified="2017-06-07" version="1">MDIAILLGLIVLSAVISTAEIGFFSVNETKLRALAQNHNARAKMALRLRSDPQKLLSTILVGDRLVGTAIPMYATFLTLNAYGERTFFDDTIAVVVGLLTFVLLVSVDVIPKTLAAKFAVPVTLSMAYPVYGVQVVLRPVLFIMVPLIYKLTGGKGLTLPLVTEEELKIMLEEGGKAGAIEVEKVKMIKNVFQLKDITAEDAMTPRLYVFSIDGNLRLKEAQELLYSSKYSRIPVYDGTLDNITGILYKTKALTELSKGHFDSKLKDIAYPPLFVPAGKTADDLMKQFQQDKRHMAVVVNEFGGVMGIVTLEDLIEEVVGEIMDETDITEELIKRIGKNHILVHGRTEVRKVNDFLKVELGDEAVTIGGLIQQELGRIPKVGEELRIGNCRILIHEAEPRSIKSVQIFREEKSPVSVEAPNLNLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I924</accession>
    <name>A0A1W1I924_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator with HD-GYP domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3136"/>
    <dbReference type="EnsemblBacteria" id="SLM49303">
        <property type="protein sequence ID" value="SLM49303"/>
        <property type="gene ID" value="NSJP_3136"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3136"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="18"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="173"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="380" mass="42984" checksum="DBD1346B7585C7AA" modified="2017-06-07" version="1">MTLLLDPANRQTTLDLKRLLIVDDEEPIRRLLGYMLQSHGYETILAADAKEARQRLEEQPFALVLCDVNMPGESGMDLVRSILADYPYTAAIMVTGLDSAVLANAALDMGAFGYVVKPFESNEVLINVTNALRRRRLEIENKLHRDNLEDIVRTRTMALQQALEWLERSEKELRLSREETIQRLAIAAEYRDGATAQHIQRMSRYSELLARRYGLPNERCELIRTASPMHDIGKIGTPDHVLLKPGKFTQDELYVMAQHAEIGYRILAGSEAEILNVAATIALTHHERWDGTGYPRGLKGEEIPIEGRIVAIADAFDALTTARVYKPAFEFDHAVELMVKKRGLHFDPELLDVFLASLGDIRRIYEQYADKATLGSIRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I961</accession>
    <name>A0A1W1I961_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Nudix hydrolase, MutT family (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3176"/>
    <dbReference type="EnsemblBacteria" id="SLM49343">
        <property type="protein sequence ID" value="SLM49343"/>
        <property type="gene ID" value="NSJP_3176"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3176"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029401">
        <property type="entry name" value="Nudix_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14803">
        <property type="entry name" value="Nudix_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="222" mass="24545" checksum="26E2DEF69F9214EE" modified="2017-06-07" version="1">MLSIGFIHTTGQALPEHTGGRRRPRAFASTGIDVMNFCSACGNPVSQKIPEGDNMVRFVCATCTVIHYHNPKIVAGCIPEWNDRILLCRRAIEPKSGLWTFPAGFMEIGESTEQAAIRETAEEAQAEVALTSLHSVLSLPHIGQVYLVFIGKMRTERFGAGTESLDVRLFHPSEIPWDQIAFTVVREALRRYVDDLAKGEMTLHVASIPGSLAKPRLEDDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I974</accession>
    <name>A0A1W1I974_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-(Acyl-carrier-protein) reductase</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG</name>
        <name evidence="1" type="ORF">NSJP_3410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3410"/>
    <dbReference type="EnsemblBacteria" id="SLM49577">
        <property type="protein sequence ID" value="SLM49577"/>
        <property type="gene ID" value="NSJP_3410"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3410"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="257" mass="27527" checksum="5F19EC0F0FF08D91" modified="2017-06-07" version="1">MRHAQIVSETDRGGIARGKRPAVLVTGASGIIGRAISLAFAATGWHIGIHYHRNTQAAGATLEQVRADGGEGALYQADLRDSRSMRQMAEAFAKDAPQEWACVCNAGIGASDMLIRQRVDRWSDIIETNLTGTFHCMQAVGRILCAGNGGSIVVIGSHAGFHGTTGQAAYAASKAGLLGLMKTAALEWGPRNVRVNLLLPGWQKTPLSQSAMSDDDTRIDHALHRTPSIESVARMVVHLIQAEDVSGQIWNCDSRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I982</accession>
    <name>A0A1W1I982_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">coaD</name>
        <name evidence="8" type="ORF">NSJP_3383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3383"/>
    <dbReference type="EnsemblBacteria" id="SLM49550">
        <property type="protein sequence ID" value="SLM49550"/>
        <property type="gene ID" value="NSJP_3383"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3383"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="123"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="162" mass="18168" checksum="9CBBF0D39D07C115" modified="2017-06-07" version="1">MKIAICPGTFDPITHGHADIITRSLRVFDKVVVAVAPNPTKHPLFDMAERVEMVKLVMKDLGQVEVVTFDGLLVDYVQKSGAHAIIRGLRAISDFEHEFQMALVNRKLAKQVETVFLMPSEEYSYLSSTIIKDIAMHGGSLTAFLHPEVARRLQTRIRSLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9B6</accession>
    <name>A0A1W1I9B6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoD</name>
        <name evidence="6" type="synonym">sigA</name>
        <name evidence="11" type="ORF">NSJP_3461</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3461"/>
    <dbReference type="EnsemblBacteria" id="SLM49628">
        <property type="protein sequence ID" value="SLM49628"/>
        <property type="gene ID" value="NSJP_3461"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3461"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007631">
        <property type="entry name" value="RNA_pol_sigma_70_non-ess"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007127">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042189">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04546">
        <property type="entry name" value="Sigma70_ner"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03979">
        <property type="entry name" value="Sigma70_r1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="9">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="10">
        <location>
            <begin position="560"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="6">
        <location>
            <begin position="367"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="6">
        <location>
            <begin position="446"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="6">
        <location>
            <begin position="535"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="219"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="317"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="6">
        <location>
            <begin position="391"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM49628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="602" mass="68843" checksum="B9ED18B2A9AF08BF" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9C5</accession>
    <name>A0A1W1I9C5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase (Modular protein)</fullName>
            <ecNumber evidence="7">2.7.8.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3447"/>
    <dbReference type="EnsemblBacteria" id="SLM49614">
        <property type="protein sequence ID" value="SLM49614"/>
        <property type="gene ID" value="NSJP_3447"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3447"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="544" mass="59343" checksum="E13D4639F3A0E4AE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9C8</accession>
    <name>A0A1W1I9C8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD-dependent malic enzyme</fullName>
            <ecNumber evidence="6">1.1.1.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3439</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.38" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3439"/>
    <dbReference type="EnsemblBacteria" id="SLM49606">
        <property type="protein sequence ID" value="SLM49606"/>
        <property type="gene ID" value="NSJP_3439"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3439"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="13"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
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        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="480" mass="50750" checksum="4F8753DCC312AA5B" modified="2017-06-07" version="1">MNDLGPYSNYRLTVRLELANKPGMFANVAAVLAMEGANLGAVDIVSATSASMIRDVTFDVRDEAHGEHVLMRLGALSDVKVLSASDRIFLLHLGGKIQVQSKVPINTRNVLSMVYTPGVGRVSQAIAKDRSKAYAFTTKSNSVAVVTDGSAVLGLGNLGPEAALPVMEGKAMLFRELAGIDAWPICLDTQEVDAVVRTVQAIAPGFGAINLEDISAPRCFEIERRLKESLAIPLMHDDQHGTAVVILAALTNALAVVGKAIEDVWVVVNGLGAAGTACCRMLLAAGVSHLVGCDKPGIILQGDGERLRACRQDLLSCLTPLQPAGTLQDALRGADVFIGLSVGNLLKAEDLDLMASDRIVFAMANPDPEVSPELAASHCRIFATGRSDFPNQINNALAFPGIFRGALDVQAVAINEPMKLAAAKALAESIPRTTLTEDYIIPSVFDKEVVPKVAKAVSAAAHETGVARRRNKIGDQFSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9K8</accession>
    <name>A0A1W1I9K8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49483">
        <property type="protein sequence ID" value="SLM49483"/>
        <property type="gene ID" value="NSJP_3316"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3316"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013094130" evidence="1">
        <location>
            <begin position="24"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="135" mass="14850" checksum="9FB485254ED194B9" modified="2017-06-07" version="1">MTVMHWAIGFALSVFLWTGSAFAADPADVEKFVKARIEIGEMMTNYFSGGGSNGTGQPPSPERMQDMRADINTKLGKVLAKYDLTVEEYRARSKEVFADEAGVKSFLEANPDLKQRYDALPLDRMGRSGGSGRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9P0</accession>
    <name>A0A1W1I9P0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="SLM49716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="NSJP_3549"/>
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    <dbReference type="KEGG" id="nja:NSJP_3549"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="42" mass="4575" checksum="93C147FBFAF64030" modified="2017-06-07" version="1">MGITDRQMVRIERAFTDCLCRECLTNVVAGEEGSVSDPSSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9P2</accession>
    <name>A0A1W1I9P2_9BACT</name>
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        <submittedName>
            <fullName evidence="8">Putative Competence protein ComEC/Rec2 related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_3567</name>
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    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="SLM49734">
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        <property type="gene ID" value="NSJP_3567"/>
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        <property type="component" value="Chromosome i"/>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:establishment of competence for transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ComEC_N"/>
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        <property type="entry name" value="Competence_ComEC/Rec2"/>
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        <property type="entry name" value="DUF4131"/>
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        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Lactamase_B"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ComEC_N-term"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
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        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="69"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="396"/>
            <end position="418"/>
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        <location>
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        <location>
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    </feature>
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        <location>
            <begin position="519"/>
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            <begin position="553"/>
            <end position="763"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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    </evidence>
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            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49734.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="842" mass="92887" checksum="FF3793D4282C6DE4" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Q9</accession>
    <name>A0A1W1I9Q9_9BACT</name>
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            <fullName evidence="3">Putative Exopolysaccharide biosynthesis related tyrosine-protein kinase</fullName>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="SLM49609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="SLM49609"/>
        <property type="gene ID" value="NSJP_3442"/>
    </dbReference>
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        <property type="component" value="Chromosome i"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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            <end position="263"/>
        </location>
    </feature>
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        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="275" mass="30448" checksum="853112C43EFFA0E9" modified="2017-06-07" version="1">MDRLRAAVQLFKDRGKHSASPRSTGRNNDQSEFEPIVYTRTRSLDVPTPVLRRQRVMAAYGKGPYVDAYKILRTQILQRLRQHDWNVLGVTSPGYGEGKTLVAANLAVSLAMEMTQTVLLVDSNLQGPGIHEVFGMGACRGLADYLLDNEPVEDLLVHPDMGRLVVLPAGRAIPNSAEVLISPKMLALVEEFKHRYPSRVVIFDLPPLLHTADVLAFSPYTDALLLVVEEGKTTVEELQRALLLVKDRRPVLGTVINKAGRSDLSPAGMRKLLTH</sequence>
</entry>
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    <accession>A0A1W1I9U1</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <lineage>
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                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="SLM49766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA09</accession>
    <name>A0A1W1IA09_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3436</name>
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    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArsC family.</text>
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    </dbReference>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="116" mass="13117" checksum="688E59F4D25AC008" modified="2017-06-07" version="1">MPDMIIYEKPTCSTCRQAVQLAKDSGKSFKTVNYYTTPFTKAKLTALLKKGRLSARDVLRTKEDVYRELGLAKKNLSGDELIDLMLKHPDLIQRPIVEAGDRVLLARPADQIKQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA26</accession>
    <name>A0A1W1IA26_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="NSJP_3707"/>
    </dbReference>
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        <property type="component" value="Chromosome i"/>
    </dbReference>
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        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="408" mass="46028" checksum="B4A0BC46A7FD5DEE" modified="2017-06-07" version="1">MKHWIFAVLLIGMTCHEGLAQTQPEMEFTPGPRMIRAVEQIAGSYAHLGHSLELTSQQKQAMADLVQRVKTDMWLKEAVLVGMFQELEEKRRRGLLQEHEYRTANALTGGIETDELNLFIDTLTALRAVLTAEQATKVRELMHPPMVFRVSQGFNTKIGLLSLDGVGQVYNGFRRELVLDDLQVRDIGSWLEEARREVLRVGTEIDLSRVEADELVMRPDVDPEVIRAKMQKTGETEGVLFNTLFQVTDRIQARLTEQQRTKLAELKQHHMRTASDKPRSGHSGGPHGTPAHQTGFDYFLDHGGRIGINEEQTAALVQVKNDTRKTLLIEQAKVKASELKLLSLLRSSGGETTQPSEEKLAAAVQEMEQGRTRMTRAKVLGYLDARRLLTLEQQLRVHPPDTFEEGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA56</accession>
    <name>A0A1W1IA56_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
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            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49927">
        <property type="protein sequence ID" value="SLM49927"/>
        <property type="gene ID" value="NSJP_3760"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3760"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="54" mass="6608" checksum="47D3E23BB3E42210" modified="2017-06-07" version="1">MRRWQRALLELLAKRDRISSGWSRQMATIRNRKGFRLLARGLFFRHRSLDQTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA61</accession>
    <name>A0A1W1IA61_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49653">
        <property type="protein sequence ID" value="SLM49653"/>
        <property type="gene ID" value="NSJP_3486"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3486"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="83" mass="9651" checksum="2AF5787AE784ABAA" modified="2017-06-07" version="1">MITLSTAAYEHADHSLPEDLILDRLQDGRRFTIEEMLVQVPELSWAQLFLAMDILSRRGDVELRRRGFTYTLKRVRAAAMESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA88</accession>
    <name>A0A1W1IA88_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Adenylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3632"/>
    <dbReference type="EnsemblBacteria" id="SLM49799">
        <property type="protein sequence ID" value="SLM49799"/>
        <property type="gene ID" value="NSJP_3632"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3632"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007890">
        <property type="entry name" value="CHASE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05226">
        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01080">
        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="433"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="623" mass="67554" checksum="B1645BEE8B3AB874" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAA8</accession>
    <name>A0A1W1IAA8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="NSJP_3769"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3769"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
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        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="241" mass="26203" checksum="54DAE33ADD145C41" modified="2017-06-07" version="1">MQKFSSHQVWATVSGRDRDDIMKQIDSLVCWGVRAIEFRVDLIPEALWDSILGIGSLPVPWWVAHFGTGKDADTAKTAIAETLRSDAEGAIFHSRCEHLSDLIAMCQKAGRPFAAPYHSQNPMTRNEAIREFEYQATLTPAFRKIAARARTYAEAAAIVDATHTASKAGGSPVVGAVFGPQRWARIALPHAGSAITFILAHAVENEVGGDDQQLHLGDIHHLSAVKDLLAIQRGAHASTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAB2</accession>
    <name>A0A1W1IAB2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49819">
        <property type="protein sequence ID" value="SLM49819"/>
        <property type="gene ID" value="NSJP_3652"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3652"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="89" mass="10113" checksum="9C688EF4F85BB135" modified="2017-06-07" version="1">MLPLGVACTYTWGPRTKEWGQSALTVAVIDVSKPTMVCAKTWFSKVFSFNDKLAGQMRLRFPASVTQPCSHSKLVRLMPWQRPILREKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAD1</accession>
    <name>A0A1W1IAD1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50008">
        <property type="protein sequence ID" value="SLM50008"/>
        <property type="gene ID" value="NSJP_3841"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3841"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="57" mass="6267" checksum="E6CC7D55E0CFAF6A" modified="2017-06-07" version="1">MLAVVPPRLPYHPLFRSALQPVQTQSTRGHHAISNDLLGSDQTGRQNAHRFVPPAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAE7</accession>
    <name>A0A1W1IAE7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50028">
        <property type="protein sequence ID" value="SLM50028"/>
        <property type="gene ID" value="NSJP_3861"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3861"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="267" mass="29143" checksum="640C63267A7E8705" modified="2017-06-07" version="1">MMSLPPGAAPLFAAVVIGTVACWPVSQARSETCSLQADHAGLTFPIDKVDADWTCRLQPVVDDYTTANKIGPVRTALTETLYTYLLDRPPTAAALINRLDLGLYKSEIRGPGLYWGDDGEGTQGLVHLVYHDRSSRIYYLEGTHHSRLLPSLTGKAVVLLRTKVVREPEGTESMDTTMVSYMKVDNRFVSGVLSLLRPLIGSTVEKKLAKGLDTVNRLGVEMRRHPDRVLSEAMDPPALDAADVAFLQRALADPAQVPGRPHDGMVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAI2</accession>
    <name>A0A1W1IAI2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin, 2Fe-2s</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3606"/>
    <dbReference type="EnsemblBacteria" id="SLM49773">
        <property type="protein sequence ID" value="SLM49773"/>
        <property type="gene ID" value="NSJP_3606"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3606"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="108" mass="11432" checksum="DB5C1F95DBA7E9CA" modified="2017-06-07" version="1">MPKPKYHIVVCTNARPPGHPKPSCGSQGSAQLLMAFNMGLMQRGVMPGEVLVSGSSCLGPCEQGPTVVVYPDGTWYSKVTEADVATILDEHIKGGKPAAKLNPDAVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAK9</accession>
    <name>A0A1W1IAK9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3921</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50088">
        <property type="protein sequence ID" value="SLM50088"/>
        <property type="gene ID" value="NSJP_3921"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3921"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="30"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="132"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="190" mass="21169" checksum="3C25A6F7C2337C19" modified="2017-06-07" version="1">MTVLRGPERICAPGSFPEDIAMSGHDLAHLFSDHAPDVQRFLASRVSCEATAADLTQETFLRLAQLPDLQAIENFRTYVFRIAANLATDHLRARARRRSSMEDREEGVLDHPDGASTPEAALLAKEELATALAALEELSPLCRRIFSLNRFEGLPHRAIAGRLDISLSTVEKNIARALNHCRRRMKEASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAM8</accession>
    <name>A0A1W1IAM8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50045">
        <property type="protein sequence ID" value="SLM50045"/>
        <property type="gene ID" value="NSJP_3878"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3878"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="104" mass="11810" checksum="ED33F94F13599C82" modified="2017-06-07" version="1">MEEIQMSNLEKAEVIRKWINPEERVSVQFDDARDLNAEVTGCTDQLVALALDTDVPHMRQQLSIPLSKVEVAADPSHYTRDPDQPLQQERLLLLVKGSRPAVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAR1</accession>
    <name>A0A1W1IAR1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TonB-dependent siderophore receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_3919</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50086">
        <property type="protein sequence ID" value="SLM50086"/>
        <property type="gene ID" value="NSJP_3919"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3919"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07660">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0798">TonB box</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="STN" evidence="10">
        <location>
            <begin position="76"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM50086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="837" mass="93107" checksum="1A8462487CF895D6" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB08</accession>
    <name>A0A1W1IB08_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50165">
        <property type="protein sequence ID" value="SLM50165"/>
        <property type="gene ID" value="NSJP_3998"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3998"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="593" mass="65722" checksum="A6E8455217B62465" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB35</accession>
    <name>A0A1W1IB35_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3816"/>
    <dbReference type="EnsemblBacteria" id="SLM49983">
        <property type="protein sequence ID" value="SLM49983"/>
        <property type="gene ID" value="NSJP_3816"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3816"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013630">
        <property type="entry name" value="Methyltransf_Zn-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038576">
        <property type="entry name" value="Methyltransf_Zn-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013691">
        <property type="entry name" value="MeTrfase_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08421">
        <property type="entry name" value="Methyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08484">
        <property type="entry name" value="Methyltransf_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_13" evidence="1">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_14" evidence="2">
        <location>
            <begin position="269"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="434" mass="48873" checksum="7184822D76F2E28E" modified="2017-06-07" version="1">MLKLSTVASSFFGSNMPIVTHMHPENGHCRFCGAPLEDTFVDLGMSPPCQTHIEPHQLHHMEAFYPLHAFVCAKCFLVQLKAYIAPQDIFTEYAYFSSYSNSWLQHAQAYTEAMVKRLGLSVASRVVEIASNDGYLLQYFAKKGIPVLGIEPAANVAQVAIEKGIPSVTKFFGAETAKELVASNSHADLLLGNNVLAHVPDLNDFVRGMKLLLKATGVITMEFPHLMRLMEGNQFDTIYHEHFSYLSFCTVERLFAAHGLTIFDVEELPTHGGSLRIYARHTEAVSMPVSAAVETLRTREFGAGFGKLEHYRSFRNQVGNTKRRLLETLIEIKRKGKRIAGYGAPGKGNTLLNYCAIRTDFLDYTVDRNPYKQGKYTPGTHIPIHPEDRIRTTQPDYVLILPWNLKNEIMEQLAYIREWGGKFIVPIPEVAIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB38</accession>
    <name>A0A1W1IB38_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc transporter ZitB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">zitB</name>
        <name evidence="7" type="ORF">NSJP_4100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4100"/>
    <dbReference type="EnsemblBacteria" id="SLM50267">
        <property type="protein sequence ID" value="SLM50267"/>
        <property type="gene ID" value="NSJP_4100"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4100"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM50267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="312" mass="33630" checksum="EA0329BFC313B54B" modified="2017-06-07" version="1">MTSLAAYHHLRSRLHLALALNAVVIVGEFAGGWLLNSIALMSDAGHNLVDQGSLFLALYAHLLTSRPATESRTFGYHRAGMIAAFLNSFILLLTAGGILIIGITRLFEPVVVNGAWMMGIATVSFAANLGIALLLQQGAKDDLNIRSAFWHMLADAWVSLGVIVSGGAILLTGWTVLDPLISIFVVAAIVHGSWPIFKESLEVLLESTPPGINASNVTATIESIPGVANVHDLHIWAIEPRLIMLTCHILTEDSMDTTALLKTIRDRITGDFGIKHMTIQLETSCAHPDTVHCNLNTLRDQHSAVASAHVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB93</accession>
    <name>A0A1W1IB93_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_4105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50272">
        <property type="protein sequence ID" value="SLM50272"/>
        <property type="gene ID" value="NSJP_4105"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4105"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="117" mass="12942" checksum="5F7F45A26FEF8FBD" modified="2017-06-07" version="1">MLETPPSMNPLFPKGRRSEVWRSGLSVWLMLLLLTMAPFAVAQDVHHELAAADDDGHEHSDADLCQWVQHHTSGSLDFSGPVFTVWEIVRHYEVPPQSLLLSAECSSAGPSRAPPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB98</accession>
    <name>A0A1W1IB98_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_4127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4127"/>
    <dbReference type="EnsemblBacteria" id="SLM50294">
        <property type="protein sequence ID" value="SLM50294"/>
        <property type="gene ID" value="NSJP_4127"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4127"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="425" mass="46270" checksum="14CFB02D66421D38" modified="2017-06-07" version="1">MTEERRNSLPPWLATLSWYFDATIRLLLLVYVATLPFKRLLFVERHAFIVLLGLLVIWCVVRRRLFYRKTPYDVWLLAFVLWVGLTIPFAAFPSYSFKEYGKLLQGVTTLYAVVWFLTDLGSRTVLLLVLGTSLFLVSAYGLTQFNVADPQAIISSFPAEVWLTTFLVMTLPYALAAAYGDHSPIMTGVGAALSVLAAACLLSTQSRAGLIAFAAELVVMAWLVRTSLAKWTAGVVTLGLVLVVLLAVWLKSPVPVAEQPAVQTSIPVKTGLASIVHRFDIWKFTLSEIGEHWLVGVGYGGQTYAMLYGDDAETVAPGHAAVKAQGAHNILLYLALHVGIAGMALFLGFYVTLVRTTAQAYRAAADGLSRSVLAGTVGSMGGLFVRLQFDQMLVGALAVLFWVLVGMSVLWLPSPESQGNETVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBP8</accession>
    <name>A0A1W1IBP8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_4026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4026"/>
    <dbReference type="EnsemblBacteria" id="SLM50193">
        <property type="protein sequence ID" value="SLM50193"/>
        <property type="gene ID" value="NSJP_4026"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4026"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="160"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="349" mass="38288" checksum="C2190CD19BEEA3E4" modified="2017-06-07" version="1">MISGLAALLISSGFRVMVGLFRPGWLQEQCQHRKISVHVLPLSGIAGWRWFVACLKLVRTQRIDLIHAHEFSAIVCGWVIARLAGIPFVGTVHGKNYFWERARRRLAYRVISGSGRLVAVSQDLRQFVMEKVGLSSERIDLIYNGVESGARVSNDEARQARAELGLAPDNVVIGAIGSLYPVKGHQFLLEAMPAVLVRYPHTVLLVMGRGELEDTLKEQAKRLGLEGSVRFLGMRNDIPKLLGTLDVFVLPSLSEGLSLALLEAMAAGIPAVATKVGGNAELVVEGETGVLVPSQDAAALSKALCSLLDNRETRERFGRSAVARVEQRFSAGLMAKNYQRLYMRVLNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZN9</accession>
    <name>A0A1W1HZN9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pup--protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pafA</name>
        <name evidence="2" type="ORF">NSJP_0043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0043"/>
    <dbReference type="EnsemblBacteria" id="SLM46215">
        <property type="protein sequence ID" value="SLM46215"/>
        <property type="gene ID" value="NSJP_0043"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0043"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022279">
        <property type="entry name" value="Pup_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03686">
        <property type="entry name" value="pupylate_PafA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="464" mass="53766" checksum="1427923E67B927A7" modified="2017-06-07" version="1">MMSPGPMKQRIFGLENEYGLIFSPNGRIYLPMEKVLGYIFEGLIPNSWPSNAFLVNGARFYQDTGCHPEYSTPECDNILDLVVHDKAGERLLEACLPAAEERLREEGLSGEIYIFKNNTDSLGNTYGCHENFLMRRDVDFWKVTEQLIPFFVTRQIYSGAGKVLKVSGKPQYFISQRAQHIHEKTSSSTTSSRSIINTRDEPHADAERYRRLHIIVGDSNMSELVTYLKVGTATLVLSMIEEGYTVHGMELEDPVKAIREISRDPTVKRKVKLDDGRQLTAVEIQRVYLERAQEYLAQQDHDPILDDVWKRWATILDKLEEDPLQLVREVDWVTKRHLIQSYIDKKGCGWDDPRVFLLDLQFHDVKRTRGLYYLMESRGLVERVVEEDAVQRAMSTPPQTTRAKVRGDFIRFARAKNRSYTVDWTYLKLNGYWEETILCMDPFSAVNRRVDELVAQVSGLRFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZW0</accession>
    <name>A0A1W1HZW0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0113"/>
    <dbReference type="EnsemblBacteria" id="SLM46285">
        <property type="protein sequence ID" value="SLM46285"/>
        <property type="gene ID" value="NSJP_0113"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0113"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020945">
        <property type="entry name" value="DMSO/NO3_reduct_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036411">
        <property type="entry name" value="TorD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02613">
        <property type="entry name" value="Nitrate_red_del"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89155">
        <property type="entry name" value="SSF89155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="323" mass="36261" checksum="B8846ED4188D5060" modified="2017-06-07" version="1">MTSKQPVQNPSASGTAVISTPTPIKDSPAVERALNRSKIYLLVSWSLLYPEDDEFLDYVQCGEFVEDGRAAVEALEKALDGIDGDRAKQKLNALKKQFDQLEKLVASECVNWHLTDLQSEHRRVFSNVITLDCPPYETLFGNDHVFAQSHVMGDIAGFYKAFGVELSKDIHERLDHLSVEFEFMHFLAYKESYSRCHDGTDKTQIVVEAQKKFVKNHIGRWVPLFCRMLVKKADSGLFKLVADLTADWMDFEAAFLGVTPQPYSETDYRPATFNAPEGQTYECGAQDQGNELSLLLNETGAQDFMEQGEKNKNKEEGGPVGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZX7</accession>
    <name>A0A1W1HZX7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46306">
        <property type="protein sequence ID" value="SLM46306"/>
        <property type="gene ID" value="NSJP_0134"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0134"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="40" mass="4539" checksum="F1D8DA20CD33D434" modified="2017-06-07" version="1">MATATADSELKVKIGKMIFYITCAIGLWFFYWFAGIQCPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZZ1</accession>
    <name>A0A1W1HZZ1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NSJP_0120</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0120"/>
    <dbReference type="EnsemblBacteria" id="SLM46292">
        <property type="protein sequence ID" value="SLM46292"/>
        <property type="gene ID" value="NSJP_0120"/>
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    <dbReference type="KEGG" id="nja:NSJP_0120"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="16">
        <location>
            <begin position="356"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="14">
        <location>
            <begin position="420"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="15">
        <location>
            <begin position="492"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="14">
        <location>
            <begin position="564"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="15">
        <location>
            <begin position="776"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="841"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="679"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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        <source>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50112"/>
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        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SLM46292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1059" mass="119156" checksum="1CED048CF2960496" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I028</accession>
    <name>A0A1W1I028_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">xerD</name>
        <name evidence="10" type="synonym">xerC</name>
        <name evidence="14" type="ORF">NSJP_0188</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family. XerD subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="SLM46360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="NSJP_0188"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0188"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CB"/>
    </dbReference>
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        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011932">
        <property type="entry name" value="Recomb_XerD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02225">
        <property type="entry name" value="recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0229">DNA integration</keyword>
    <keyword evidence="8 10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="13">
        <location>
            <begin position="4"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="12">
        <location>
            <begin position="111"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM46360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="302" mass="34030" checksum="65E0F0026AFAB253" modified="2017-06-07" version="1">MNVMATDPLVERYLNHLRIEGGLARNTIESYRRDLAKFQSYLAREGVPALERVTSASLRKFLAVLRAAKLSSPSSARCLSAVRGWLRFLRVEQLIEHDPAAGVAVGRPGLRLPRTLSRDEVTALLDLPPQPSLEDARDRTMTEVLYATGLRVTELVKVEAAQVDLAVGCLRVTGKGSKQRLVPMGETARRLLQQYVDDVRPQLLKTRRSRHLFVSRRGGAMSRQGFWKMLKLRARRAGIQHAVSPHVLRHSFATHLLEGGADLRAVQAFLGHANIATTQIYTHVERERLKAVHTRYFPRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I068</accession>
    <name>A0A1W1I068_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0228"/>
    <dbReference type="EnsemblBacteria" id="SLM46400">
        <property type="protein sequence ID" value="SLM46400"/>
        <property type="gene ID" value="NSJP_0228"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0228"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="56"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="252" mass="28604" checksum="0B9045DFFC7D0E50" modified="2017-06-07" version="1">MSWPLAVLQNTLMGIKPVARLARGLHSTGLSGDAGLARQVLRFYSRFVPIEGQDILEIGPGQTLEVLEHAMAAGAKSCSAVDIEAYVSPDQAKRKQIAYRIYDGMILPFEAGCFDVVCSYTAFEHLRYPAVTLRECFRILRPGGRLVALIDLCDHSHYGRAEPDPLRVFDCLRYSERLWNLMRWNRSSYVNRLRKSEWLTLFNEVRFLLRNEESQVNEEIGRALPALSYLHKYSHDDAVTAVLTVCLEKPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I085</accession>
    <name>A0A1W1I085_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Trypsin-like serine proteases, typically periplasmic, contain C-terminal pdz domain-protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46401">
        <property type="protein sequence ID" value="SLM46401"/>
        <property type="gene ID" value="NSJP_0229"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0229"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="369" mass="39584" checksum="46DEE47681CF5F44" modified="2017-06-07" version="1">MRKAFRTTLAHRLVGRMNILILELVLVFPLLWLGWASAQDLSPREIYEQASPAVVMVMGHQDGNGGKGSGGTGSIIRPDGYVLTNAHVVVDERTGRPFPRLSVFLKPSRVTGNSQSDLSRMVRAKMVAYSQPLDLALLKLESASDPLPTVGLDDSTATRIGDRVVAIGHPEQGGLWTLTTGVISAEVDNFNGVRGKNVFQTETGLNRGNSGGPLLDTGGRMIGVNTAIARVASDGLPITSISFSLKSNVAAQWLREQGIGGRSEAGVVTPPQTQAASEVPSPPAKPVQPSPVETPVKPEKPDLNQRNPSLTNPNQENSKQANPKQTSPNQTGPEPARPYNLDKLVSERARAEAELTDMINEMRGRMKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0I2</accession>
    <name>A0A1W1I0I2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucose--hexose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UDP-glucose--hexose-1-phosphate uridylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">galT</name>
        <name evidence="16" type="ORF">NSJP_0217</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0217"/>
    <dbReference type="EnsemblBacteria" id="SLM46389">
        <property type="protein sequence ID" value="SLM46389"/>
        <property type="gene ID" value="NSJP_0217"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0217"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="14">
        <location>
            <begin position="3"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="15">
        <location>
            <begin position="190"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="12">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SLM46389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="334" mass="38061" checksum="396BC7166094EE96" modified="2017-06-07" version="1">MPDLRRDPVVGRWVIISTDRSGRPHDFTQLLPSRPISTALCPFCPGQERLTPKEIMAYRPQPSEANAPNWSVRVVPNKFPALQVEGELGREGLGLYDRMNGIGAHEVIIETPGHKDGLGDLPAQKIEDVLWAYRDRILDLKKDPRFRYILIFKNHGASAGATLEHSHSQLIALPIIPTSVSGEIEGCRAHYQQKERCIYCDIIRQDLTDGDRIVAENPEFVCVTPFAPRFPFEMWVLPKQHAGYFEEGQKGQFEFLASMLSEVLRRMDKVLARPPYNFVLHSSPPHEHTGDFYHWHLEIIPKLTQVAGFEWGTGFYINPVSPEESAKFLRDTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0J2</accession>
    <name>A0A1W1I0J2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">ilvD</name>
        <name evidence="16" type="ORF">NSJP_0227</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0227"/>
    <dbReference type="EnsemblBacteria" id="SLM46399">
        <property type="protein sequence ID" value="SLM46399"/>
        <property type="gene ID" value="NSJP_0227"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0227"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SLM46399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="553" mass="58204" checksum="6975A9A0017E25F7" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0M2</accession>
    <name>A0A1W1I0M2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type transport system, ATPase component</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_0257</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0257"/>
    <dbReference type="EnsemblBacteria" id="SLM46429">
        <property type="protein sequence ID" value="SLM46429"/>
        <property type="gene ID" value="NSJP_0257"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0257"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="310" mass="34333" checksum="B63DB86078697224" modified="2017-06-07" version="1">MEAIVLDGVSKVHTPSWPWQKPVQGLDNVSFTVNRGEIFGFLGPNGAGKTTTMKILLGLMKASRGSIRLLGMPGDDVMVHHRIGYLPESPYFYDYLTAEEFLSFYGRLGGMDKGRLAGAVPSLLERVGLLDAQHRQLRKFSKGMLQRIGLAQALIHDPELVILDEPMSGLDPVGRKEVRDIILSLRDRGKTVFFSTHIISDVEMVCDRVCILSKGKVLALGKVEELVNEQAQQSVEIVSDGIIGEDIPLIRRVATRILQRGDRCLIMLPRLEQLDEVLTAIRQAGGRLLSAVPHKGNLETLFIERTNQGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Q4</accession>
    <name>A0A1W1I0Q4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0261"/>
    <dbReference type="EnsemblBacteria" id="SLM46433">
        <property type="protein sequence ID" value="SLM46433"/>
        <property type="gene ID" value="NSJP_0261"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0261"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="303"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="337"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="474"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="544" mass="61016" checksum="6172F080270B9B79" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0T2</accession>
    <name>A0A1W1I0T2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46587">
        <property type="protein sequence ID" value="SLM46587"/>
        <property type="gene ID" value="NSJP_0415"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0415"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012709517" evidence="1">
        <location>
            <begin position="28"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="150" mass="14764" checksum="EC6E5CAEC9D04AAE" modified="2017-06-07" version="1">MELDEAQANRLALAALLLAAVVTSACAAHQPTLRANAKYQLQGREGSQLDIADCQRKAEAAGLNPGTEARSGNVAAGAGLGLIVGAAVGATSGISGGPAGIAIGAAAGAGLGLIIGSVGGAYRPLEPDPPYADAVVRCLIEKGYEVTGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0T9</accession>
    <name>A0A1W1I0T9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fkpA</name>
        <name evidence="8" type="ORF">NSJP_0444</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0444"/>
    <dbReference type="EnsemblBacteria" id="SLM46616">
        <property type="protein sequence ID" value="SLM46616"/>
        <property type="gene ID" value="NSJP_0444"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0444"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000774">
        <property type="entry name" value="PPIase_FKBP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036944">
        <property type="entry name" value="PPIase_FKBP_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01346">
        <property type="entry name" value="FKBP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012867953" description="Peptidyl-prolyl cis-trans isomerase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="136"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="224" mass="23548" checksum="94D9E23408C9D205" modified="2017-06-07" version="1">MRPVTIVTMLLSLMLSAIPAGAADPSTDDQKTFYALGLLISQSLTPFALTESELDFVRSGMSDGVLKKTPKVDLQAFGPKVNQLQQARASALADTEKKAGATFIAKAAAESGAKKTESGAIVTTIKEGKGATPTATDTVKVHYHGTLIDGTVFDSSVKRGEPATFPLNQVIKCWTEGVQLIKVGGKSKLVCPSAIAYGDRGSPPTIKPGATLVFEVELLEIVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0V4</accession>
    <name>A0A1W1I0V4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46635">
        <property type="protein sequence ID" value="SLM46635"/>
        <property type="gene ID" value="NSJP_0463"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0463"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="68" mass="7682" checksum="BAD893963755B166" modified="2017-06-07" version="1">MPSCSLLWLPAYVEESIPKAPLYHTRFRRETGRGIDPEAIEVREFYGRVGDGMKGRSAASNPSTRRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I187</accession>
    <name>A0A1W1I187_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46603">
        <property type="protein sequence ID" value="SLM46603"/>
        <property type="gene ID" value="NSJP_0431"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0431"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="134" mass="15458" checksum="C423A587FAF8A360" modified="2017-06-07" version="1">MKSEPERAAHRRFVQALQHEHLICTRPDCGGPMDVVDLTVHHAAVKTYQAECERCHAVEHITGKVDTHPSWDIASITLMAEMHLLHDQPVCPFDDTPITFTSMPNPRRKARYRLSCYYCGRHTEMNWPPPEAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1D8</accession>
    <name>A0A1W1I1D8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0654"/>
    <dbReference type="EnsemblBacteria" id="SLM46826">
        <property type="protein sequence ID" value="SLM46826"/>
        <property type="gene ID" value="NSJP_0654"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0654"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="129" mass="15215" checksum="61F62E5BC4987F84" modified="2017-06-07" version="1">MIRIKRVYSEVGSRDGMRILVDRVWPRGISKDRAHVAEWRKDLAPSTTLRKWFGHEPARWTEFRRRYRTELVRSGMMDELQKLRRLSRKRSITLVYGAADETHNQAAALMDFITKPAGPPSRAPRRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1M6</accession>
    <name>A0A1W1I1M6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Prepilin leader peptidase/N-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
            <ecNumber evidence="10">3.4.23.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pilD</name>
        <name evidence="14" type="ORF">NSJP_0738</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine.</text>
            <dbReference type="EC" id="3.4.23.43"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase A24 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EC" id="3.4.23.43" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0738"/>
    <dbReference type="EnsemblBacteria" id="SLM46910">
        <property type="protein sequence ID" value="SLM46910"/>
        <property type="gene ID" value="NSJP_0738"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0738"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010627">
        <property type="entry name" value="Pept_A24A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014032">
        <property type="entry name" value="Peptidase_A24A_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06750">
        <property type="entry name" value="DiS_P_DiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00864">
        <property type="entry name" value="PREPILNPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="DiS_P_DiS" evidence="13">
        <location>
            <begin position="11"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="12">
        <location>
            <begin position="105"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM46910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="258" mass="27547" checksum="B5EEBEDC64CD17C5" modified="2017-06-07" version="1">MDVYLYVVVAVLGCLVGSFLNVCIFRLPRGESIVWPGSHCPACGTPIRSYDNIPVLSYLYLGGRCRACHGEIPPRYPLVEAANAIGYVGILWFFGPGWPAVLYGILFSALLVVVGTDLSHQIIPDAITLPGVVVGLLGAVTVLPVGWVNALLGIIIGGGILWVLAWISPYLFGKEGMGGGDIKLLAMIGAFLGWKPALLTIMIGSLTGSLIGLSLISFHLIKRDEYIPFGPFLAFGALVAMFFAQPILDWYQGLLGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1N2</accession>
    <name>A0A1W1I1N2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Peptidase M</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0719"/>
    <dbReference type="EnsemblBacteria" id="SLM46891">
        <property type="protein sequence ID" value="SLM46891"/>
        <property type="gene ID" value="NSJP_0719"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0719"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013003674" evidence="1">
        <location>
            <begin position="22"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="2">
        <location>
            <begin position="331"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="752" mass="83368" checksum="56285D569EB5649C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Q3</accession>
    <name>A0A1W1I1Q3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46911">
        <property type="protein sequence ID" value="SLM46911"/>
        <property type="gene ID" value="NSJP_0739"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0739"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="91" mass="10390" checksum="3FB51606E6C8AD30" modified="2017-06-07" version="1">MTRASKAKPRSPLIDLTPPPRKKRPESLTSREQEILELIWAGFKNKEIGQRLKISVKTVEAHRANMMKKLRVSNTAQLLKTSIQGGMIRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1R0</accession>
    <name>A0A1W1I1R0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0591"/>
    <dbReference type="EnsemblBacteria" id="SLM46763">
        <property type="protein sequence ID" value="SLM46763"/>
        <property type="gene ID" value="NSJP_0591"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0591"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="91" mass="9858" checksum="4E9623E56B1C7471" modified="2017-06-07" version="1">MVTIELLGQLQTVDGERDVAVELTAPVSVRQVIQRQGIQLRHLLQLIREKKVLVTINKKIASDDSLVHDGDAIRLVGHDGFGGSGLGPTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1S8</accession>
    <name>A0A1W1I1S8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="5">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">APS kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sat</name>
        <name evidence="5 8" type="synonym">cysC</name>
        <name evidence="8" type="ORF">NSJP_0647</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0647"/>
    <dbReference type="EnsemblBacteria" id="SLM46819">
        <property type="protein sequence ID" value="SLM46819"/>
        <property type="gene ID" value="NSJP_0647"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0647"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA_2" evidence="7">
        <location>
            <begin position="17"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-sulfurylase" evidence="6">
        <location>
            <begin position="180"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="5">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="412"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="592" mass="66993" checksum="C1F5978C657512B9" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I298</accession>
    <name>A0A1W1I298_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Nitrate oxidoreductase, alpha subunit</fullName>
            <ecNumber evidence="6">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nxrA</name>
        <name evidence="6" type="ORF">NSJP_0817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.4" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0817"/>
    <dbReference type="EnsemblBacteria" id="SLM46989">
        <property type="protein sequence ID" value="SLM46989"/>
        <property type="gene ID" value="NSJP_0817"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0817"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1145" mass="131593" checksum="01F021391407FE4F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2B9</accession>
    <name>A0A1W1I2B9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46963">
        <property type="protein sequence ID" value="SLM46963"/>
        <property type="gene ID" value="NSJP_0791"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0791"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="113" mass="12515" checksum="6CC6DCC1FFEA93A3" modified="2017-06-07" version="1">MKDFTADLDASGRSIEIDRTNRQEQEEVMNRGPISLVVMSLVASVIVSAMTLIVAQPFLAKAQETKRFQYRIVEVLHDTDSMQQALNEYGAGGWELVAVSAGNLTSPKLIFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2T8</accession>
    <name>A0A1W1I2T8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1113"/>
    <dbReference type="EnsemblBacteria" id="SLM47285">
        <property type="protein sequence ID" value="SLM47285"/>
        <property type="gene ID" value="NSJP_1113"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1113"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012258268" evidence="1">
        <location>
            <begin position="22"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="189" mass="21686" checksum="FA6E0ACD376B06E5" modified="2017-06-07" version="1">MQVAILIMLVLAMIASPIASRPTPVCAIEFVADQTIRAEGRVHRSSLYYRDDMWRIEHNDPGSVDITIVRKDKGLIWLLIGRMRQFATLPFDDSTDVMLDRTLVNESGRELIGTEILDGHPTAVYQVSVQNGEQVLVYYQWWADDIQLPLRLARQDGAWVVQYKNVRLRPVSSSFFELPLNYRPVETQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2U4</accession>
    <name>A0A1W1I2U4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47336">
        <property type="protein sequence ID" value="SLM47336"/>
        <property type="gene ID" value="NSJP_1164"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1164"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="183" mass="20040" checksum="ECEC790EF6822F42" modified="2017-06-07" version="1">MGEEKSLPRLAAERPHERSGRKTDIVIHAGDMLLWGLLATGLLTTLLRAGQALHLTRMDPTLLLGTMVTPDRDRAKMIGFVIHFLNGWWIALVYVLFFHALGFAEWWLGALLAVAHTAFVLLVVLPSLPGIHPRMASDESGPTPTRMLEPPGFLALNYGVRTPAAVLIAHLVYGAVLGAFYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I326</accession>
    <name>A0A1W1I326_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47410">
        <property type="protein sequence ID" value="SLM47410"/>
        <property type="gene ID" value="NSJP_1238"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1238"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="70" mass="7592" checksum="2EAE7C185C893672" modified="2017-06-07" version="1">MVRPAGESSYQPAPIDTENLLKTLEEWNHHLEVHASLSQTPLHERYEGPTSGSAALRGVPGGCKTRPNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I380</accession>
    <name>A0A1W1I380_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Hybrid histidine kinase</fullName>
            <ecNumber evidence="6">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1295"/>
    <dbReference type="EnsemblBacteria" id="SLM47467">
        <property type="protein sequence ID" value="SLM47467"/>
        <property type="gene ID" value="NSJP_1295"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1295"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="159"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="402"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="537" mass="58891" checksum="D11925E4D3D5D1C8" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3B6</accession>
    <name>A0A1W1I3B6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47369">
        <property type="protein sequence ID" value="SLM47369"/>
        <property type="gene ID" value="NSJP_1197"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1197"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="231" mass="26036" checksum="553D6FB5D651EA4C" modified="2017-06-07" version="1">MDQRTRDVQEDLKQIDRTRAALDEKLQLLDRRIDDTVRETKAATLEVFESAGEKVSHLVETMRHGPIPYLVSRATRQPLALVGGVVALGLLAAWIDRRRRSNGGIYPYFPSTIRGADVMPDDGHARTRRGVYPFFPSVESRRLNHRRTTGEPGPGSGRQPRSLLRTVGEDLTEELRHEGVRLREAALCASRSLFRDLAQTAGALLIAQLSRPSGRSRDDHVDRLPEMRRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3C6</accession>
    <name>A0A1W1I3C6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">clpX</name>
        <name evidence="9" type="ORF">NSJP_1330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ClpX chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1330"/>
    <dbReference type="EnsemblBacteria" id="SLM47502">
        <property type="protein sequence ID" value="SLM47502"/>
        <property type="gene ID" value="NSJP_1330"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1330"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="118"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="418" mass="46797" checksum="D29E0487B5D2F6F4" modified="2017-06-07" version="1">MAKQEKMDRHLRCSFCGKSRDEVRKLIAGPTVYICDECVNLCNDIIAEDWEEAKEEISSKLKKPAEIKHHLDQYVVGQERAKRILSVAVHNHYKRISAKEKDVDDVELQKGNILMVGPTGTGKTLLAQTLAKYLDVPFTLADATTLTEAGYVGEDVENIILKLLQAADYDVERAERGIVYIDEIDKISRKSDSPSITRDVSGEGVQQALLKLIEGTVANVPPQGGRKHPHQEFIQVNTSNILFICGGAFVGLEQIIEQRLNRKSMGFGAEIRSRGEVRLGELFEQVQPEDFLKYGLIPEFVGRLPVVATLDELDERALIRILTEPRNALTKQYEKLLSFEKIKLKFTEGALGAVARKAFTQKTGARGLRAILEEVMLDVMYDAPSQKQIKEVLITEDAILGKHAPIRIFDQDKDAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3E6</accession>
    <name>A0A1W1I3E6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47514">
        <property type="protein sequence ID" value="SLM47514"/>
        <property type="gene ID" value="NSJP_1342"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1342"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="83" mass="9399" checksum="B90B4F117B7BCEDA" modified="2017-06-07" version="1">MAEFHLASSVISTYSVMAERVGFEPTVPLPGRMLSKHVDSSTLAPLRNFRERDLSTHVFERQGERLTLFQCFPILPNDRGHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3H5</accession>
    <name>A0A1W1I3H5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47550">
        <property type="protein sequence ID" value="SLM47550"/>
        <property type="gene ID" value="NSJP_1378"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1378"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012009147" evidence="1">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="126" mass="14052" checksum="140910313F227DA2" modified="2017-06-07" version="1">MNVLRNLGLCLLLVASACAFNRGTLGDDIKPDIVNSIKKSSTTKAEVVALLGAPDRILQVNGRDVFQYYRYDAKAGSLLLIILNFSRLSVKSDDLFILINRDGIVEDVISSRRTEALEFRFWPFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3K8</accession>
    <name>A0A1W1I3K8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Signal transduction response regulator, receiver and diguanylate cyclase domain</fullName>
            <ecNumber evidence="4">2.7.7.65</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.65" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1435"/>
    <dbReference type="EnsemblBacteria" id="SLM47607">
        <property type="protein sequence ID" value="SLM47607"/>
        <property type="gene ID" value="NSJP_1435"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1435"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052621">
        <property type="term" value="F:diguanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="164"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="309" mass="34061" checksum="F7C383079AACCC13" modified="2017-06-07" version="1">MIAVLLIEDNDVDAQFTQDLLAEWSIEEFRITHVKTLADGLALIGQTRFDAILLDLSLPDAFGLPTVRQVHATNPAIPVVVLSGVSDQALALQAVQQGAQDYLVKGQGHPELLARAVRYAIERKRTEERLTYLAQYDHLTGLVNRSLFRDRLIQAMARSKRLQQPIGLMLLDLDRFKAVNDTLGHDIGDELLKAVSERLKSCVREVDTVARMGGDEFTIILEGVPSEASIVVVAKRIAEAISSAFELKGHHVSIGVSIGITVYPHDDQGIDELLKHSDEAMYRAKQQGGSGFYFHEASGYHTQSAHAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3M4</accession>
    <name>A0A1W1I3M4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47443">
        <property type="protein sequence ID" value="SLM47443"/>
        <property type="gene ID" value="NSJP_1271"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1271"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="58" mass="6408" checksum="DFBAF8163CA3BD4E" modified="2017-06-07" version="1">MKFSIKLTNVLTSGFDRSLQLLGMVANEPFVYFRKLPAGSAIHANPCKRICSYSKGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3P6</accession>
    <name>A0A1W1I3P6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucokinase</fullName>
            <ecNumber evidence="1">2.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">glk</name>
        <name evidence="3" type="ORF">NSJP_1399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the bacterial glucokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1399"/>
    <dbReference type="EnsemblBacteria" id="SLM47571">
        <property type="protein sequence ID" value="SLM47571"/>
        <property type="gene ID" value="NSJP_1399"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1399"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00524">
        <property type="entry name" value="Glucokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003836">
        <property type="entry name" value="Glucokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02685">
        <property type="entry name" value="Glucokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00749">
        <property type="entry name" value="glk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="5"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="354" mass="37977" checksum="3A47E5968DB09903" modified="2017-06-07" version="1">MILAGDIGGTKTHLALFDWKDERTEPIRTESFPSKEYASLEEILEEFLTPRTPSAAPLEIAAPTAGSGEPSVSSMPPEPTRITAACFGVAGPVIQNYSRTTNLPWVLDGDALAKRFDIPAVRLLNDLEATAHGILLLRPEELHTLNAGTPPTHRQAIALIAAGTGLGESILFWDGARYQPMPSEGGHTDFAPNNDNEIDLLRHVRSHYLHVSYERVLSGPGIHAIYEYVRDTKKNEPTWLAEKIAAGDPAAEIAAAGLKGQAEIATQTLDMFASIFGAEAGNLALKAMTLNGVYVGGGIAPKLLPKLTDGAFMRGFTNKGRYKRLMSTIPVYIVLNDRTGLIGAAATAARLAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3T7</accession>
    <name>A0A1W1I3T7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">clpP</name>
        <name evidence="11" type="ORF">NSJP_1331</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1331"/>
    <dbReference type="EnsemblBacteria" id="SLM47503">
        <property type="protein sequence ID" value="SLM47503"/>
        <property type="gene ID" value="NSJP_1331"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1331"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00493">
        <property type="entry name" value="clpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM47503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="210" mass="23142" checksum="FA72CE659BAC0961" modified="2017-06-07" version="1">MLVPIVVEQTNRGERAYDIYSRLLKDRIIFLGAPIDDVFANLIIAQLLFLEAEDPEKDINLYVNSPGGSVTAGLGIYDTMQYVKPPINTICLGQAASMGALLLTAGTKGKRFALPNARVMIHQPLGGFQGQATEIDIHAREILKIRERLNEIMAKHTGQPIEKIALDTERDYFMSGEEAKRYGLIDEVITRAPKALKSVGGTDKDGTKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I463</accession>
    <name>A0A1W1I463_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1620"/>
    <dbReference type="EnsemblBacteria" id="SLM47792">
        <property type="protein sequence ID" value="SLM47792"/>
        <property type="gene ID" value="NSJP_1620"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1620"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="452" mass="50591" checksum="C7608F10D4035458" modified="2017-06-07" version="1">MSEDFGKEFMMLGGTIAGFVVAMLTLMEKLLDIQNRLKTGKESKSAAPPAGKSWSDAAPTIDFFSAKPLRGTSYLLMYETGVIVAAGLLLNYVGLTLSRHLESILFLDMTGTALVAFLLGPWWGAIAALMSNSIVNWLLYPEAGADVVIFPWSLVSMTGAFYWGWMARRAGFRKYLRTGKSSALSHAWFLYIFGVGGAAVMSLPGTFVQAALQEHAAFALNPEVAETLSARVLLWEQTAHEYIESLFGLTWAESISWWVVNWFQNWVRYVPDKTMSAAIALVVLKYGYPLFERELIHGGSDGERPRDERILPLILGLIYAPSFATLLSSELYQGSVYWPLWAMPWVLITCGYFRLRYWGPSNAALKDARLQRAERYAKALKPIGKEASYEFCRRLTFATLIASLIFALCLPVLLMDFYRVTFKFFCVVYGFLLVVHLIRIAIAQNISAARAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I471</accession>
    <name>A0A1W1I471_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rpoD</name>
        <name evidence="9" type="ORF">NSJP_1497</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1497"/>
    <dbReference type="EnsemblBacteria" id="SLM47669">
        <property type="protein sequence ID" value="SLM47669"/>
        <property type="gene ID" value="NSJP_1497"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1497"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="418" mass="47046" checksum="BC40F410F30D51A4" modified="2017-06-07" version="1">MKDKLFPVEEAEKNTPVEKDTDADNPEASDLLDMIGRDSAGERTSRDAAQPSRRQAATDGPFMLESLYFQSFGERALLTREEETALAKRIDQGTASIRTTLRSIIKVLSHARRSDAVIEACQTLQLVRRLSGLSATALDKAELCLAALIRNSSGQAKFPAGVVRQLKQSLGIIREARSVLETAKDELVRCNLRLVVDVAKHYTRRGLTLLDLVQEGNIGLMKAAERYQYRKGFKFSTYATWWIRQGITRALADQSRTIRIPVHQTEASHRIMRVTRRLGQQLGRPAKLEEIAQVLRMRPERLHETVQAFQEPIALEHPVGDGTTELGELLPDVHAVPPDAHVHRTEMANQLDRILNTLTPREQTVIRLRFGIGYDQPSTLEQVGQNLSVTRERIRQIEAKALKKLKTPAIKEMFASIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4F5</accession>
    <name>A0A1W1I4F5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="16">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">murB</name>
        <name evidence="18" type="ORF">NSJP_1735</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the MurB family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="16"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1735"/>
    <dbReference type="EnsemblBacteria" id="SLM47907">
        <property type="protein sequence ID" value="SLM47907"/>
        <property type="gene ID" value="NSJP_1735"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1735"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 16" id="KW-0133">Cell shape</keyword>
    <keyword evidence="15 16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0274">FAD</keyword>
    <keyword evidence="8 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 16" id="KW-0521">NADP</keyword>
    <keyword evidence="13 16 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 16" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="17">
        <location>
            <begin position="47"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SLM47907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="317" mass="34304" checksum="C4A83D057FEB970D" modified="2017-06-07" version="1">MNRAGSRRRTKHAGTKFRKTDILAAVAGIRGAVRFDAPLDSYTSFKIGGPADVVVEPADVEDIRRLVTQARARGVPLFVVGGTNLLIRDRGIRGIVVHLGKLRAIREEPGEILYADGGAGMPTLIGYAVRRALAGLEWAAGIPGTVAGCVVMNAGTRLGEMKDALKAVRLVTASGVVRDIPASAIPFEYRRARLPKGIVVGVWLQLRKGIKKDIERVVKEYLHYRRDTQPLTLPSAGCVFKNPINDSAGRLIETLKLKGLRVGDAEVSTRHGNFIVNRGHARAADVVALIGKVRRAIKRQAGVRLDLELRIVGEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4H9</accession>
    <name>A0A1W1I4H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47723">
        <property type="protein sequence ID" value="SLM47723"/>
        <property type="gene ID" value="NSJP_1551"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1551"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="50" mass="5795" checksum="88B03AA635F09CE9" modified="2017-06-07" version="1">MLTQPRELDMVRLFWLGGSLASFQALRRHKRQIPLNSDAIDACLPKRQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4M0</accession>
    <name>A0A1W1I4M0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="8">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">metF</name>
        <name evidence="9" type="ORF">NSJP_1780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1780"/>
    <dbReference type="EnsemblBacteria" id="SLM47952">
        <property type="protein sequence ID" value="SLM47952"/>
        <property type="gene ID" value="NSJP_1780"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1780"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106312">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="295" mass="31805" checksum="542D6F384A576A94" modified="2017-06-07" version="1">MTREPSRLKDVLDRKQFAVTVEYNPPKGTNVTGLLDNARQLVGRVHGVNVTDNTAAVVRAGSLPVCRLLYELGHDPVMQLTCRDRNRIAMQSDLMGAHLLGIRNVLCLTGDYPTVGDHKDAKPVYDLDSVQVMQLVQGLNDGRDMAGNKLDGATAFQIGAAVTPEADPLGPMLAKFEVKVKAGAGFFQTQAIYNPEQFASFMTAVRPFKVKVLAGILVLRNAKMAEFMNAHIPGVSVPQAMIDELRAAGDKSEDAGVEIAVRTIAAVRPHCDGVHIMAIKATHRLGEILTKSGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4R6</accession>
    <name>A0A1W1I4R6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1845</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1845"/>
    <dbReference type="EnsemblBacteria" id="SLM48017">
        <property type="protein sequence ID" value="SLM48017"/>
        <property type="gene ID" value="NSJP_1845"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1845"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022563">
        <property type="entry name" value="DUF3463"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017833">
        <property type="entry name" value="Hopanoid_synth-assoc_rSAM_HpnH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11946">
        <property type="entry name" value="DUF3463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00397">
        <property type="entry name" value="adenosyl-hopene_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03470">
        <property type="entry name" value="HpnH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="20"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="338" mass="38482" checksum="22B4D551361D9545" modified="2017-06-07" version="1">MAVPVSQMVTVTKYVLTQRLKGVKRYPLVLMLEPLFRCNLACAGCGKIQYPDHVLDKRLTPEQCWAAAEECGAPIVSIPGGEPLIHPEIAKIVEGLVAQQRYVYLCTNAILLERKLDEYKPSKFLTFSVHMDGLRDEHDLAVCRDGVYDVAIKAIKAALKRGHRVTTNTTLFDDANPERVRKFFDEMMALGVEGMMISPGYSYQKAPDQQHFLKRERTRELFTRILSRPKAGWQFNQSPLFLDFLMGRREYECTPWGNPTYNVFGWQKPCYLLQEGYAKTFRELMETTAWDQYGSAKNEKCADCMVHCGYEASAVQDTFGTVSGFSRTVKLTLLPTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4S5</accession>
    <name>A0A1W1I4S5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NSJP_1830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1830"/>
    <dbReference type="EnsemblBacteria" id="SLM48002">
        <property type="protein sequence ID" value="SLM48002"/>
        <property type="gene ID" value="NSJP_1830"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1830"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
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</entry>
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                <person name="Scott M.A."/>
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                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="SLM48032.1"/>
        </source>
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        </source>
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    <sequence length="701" mass="74274" checksum="A783C5FB17240142" modified="2017-06-07" version="1"> </sequence>
</entry>
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    <accession>A0A1W1I514</accession>
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                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome i"/>
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            <dbReference type="EMBL" id="SLM48090.1"/>
        </source>
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            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="92" mass="10862" checksum="278AC6E1C3330C42" modified="2017-06-07" version="1">MDSTSDCLTLGKRLQEHPAWEDSRRYSYWSLLSFKVDVGLLSVEMLTLIRIVDRRKGTLYIRGQEYTEAWPLIFTGLDMNTAQKPLRTYRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I586</accession>
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                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48145.1"/>
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        <property type="component" value="Chromosome i"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHASE2"/>
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        <property type="entry name" value="Homeobox-like_sf"/>
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        <property type="entry name" value="Sigma_54_int"/>
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        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="881" mass="96415" checksum="BC24DFFCBC857452" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I588</accession>
    <name>A0A1W1I588_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Release factor glutamine methyltransferase</fullName>
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        <alternativeName>
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        <alternativeName>
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        </alternativeName>
        <alternativeName>
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        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">prmC</name>
        <name evidence="9" type="ORF">NSJP_2002</name>
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    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2002"/>
    <dbReference type="EnsemblBacteria" id="SLM48174">
        <property type="protein sequence ID" value="SLM48174"/>
        <property type="gene ID" value="NSJP_2002"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2002"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="8">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="MTS" evidence="7">
        <location>
            <begin position="118"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="133"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="203"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="300" mass="32778" checksum="A4EC49924F96C13A" modified="2017-06-07" version="1">MSPSSSGAAAEECRTVGRVIAEASRRLSEAGLDTADQEAVWLAEYALGLSRLQQVLHGNRELSSSDIAALQQLVSRRTEREPLQYILGTQDFCGLEFEVNRSVLIPRPESALLVQETLRRVSSRERPVLVDVGTGSGCLAIALARLVSPQQLFAIDLSPEALRTAKQNAERLGIESVTWLEGDLLTPLAERGLEGRVRAIVSNPPYVSESDWPTLQPEVRLHEPRLALVSGPRGTELHERLILGAIPFLEAGGSLIMELGWGQSRSLIEFVEACPAYQSVETLRDEAGIERVLIAERGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5D7</accession>
    <name>A0A1W1I5D7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">OmpA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1969</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1969"/>
    <dbReference type="EnsemblBacteria" id="SLM48141">
        <property type="protein sequence ID" value="SLM48141"/>
        <property type="gene ID" value="NSJP_1969"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1969"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="5">
        <location>
            <begin position="94"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="275" mass="28868" checksum="7475C8E4D32F0D5F" modified="2017-06-07" version="1">MSKSPSQVTSGPITPVISGPKKDKEVLLFSGLIVSLAVIIGGFWYYSSIEHTTAAVPDRLTGTEVSNALKGTVQPVATPVSLPATKSQEASQTPSAPDIIHRDLYFEVGRKGLTDEAKSIIQQQAVLLTNDGDLGVLVQGYTDRQGSAGYNLALGLKRAEAVKTELMSAGVAEHQIKTVSLGKEGVLCIDNSDVCRQMNRRVHLEIRTIGQEHMAPPVIATTPEPSASVETTQASAEPQPSSEDQSSLSEILIPSAGAAQPSDPNGTTLEPASGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5G4</accession>
    <name>A0A1W1I5G4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">uppP</name>
        <name evidence="15" type="ORF">NSJP_2086</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2086"/>
    <dbReference type="EnsemblBacteria" id="SLM48258">
        <property type="protein sequence ID" value="SLM48258"/>
        <property type="gene ID" value="NSJP_2086"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2086"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00753">
        <property type="entry name" value="undec_PP_bacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SLM48258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="291" mass="31217" checksum="5308629C2B9BE278" modified="2017-06-07" version="1">MNEWGPALAVILGIVEGLTEFLPVSSTGHLILVGHALGFTGDLAANAEISIQLGAILAVVAYEREKLRTLLSRAMGEQADFRRSIGGGTESLSLTLRRSLVAHPHLWFLIGLGAAFLPAGLVGLATHGWIKAHLFSPQTVAITSIVGGLIILAVEARTRKPDVQQLEQVGLRQAIMIGVAQCASLVPGMSRSGSTIIGGLLVGLDRKVATEYSFFLALPTLIVATCYQIWKSRGVFQQEDYVALAIGLAVSFVVAWIVIAAFLSFVKHHTLRPFAYYRIVMGLAVLYIFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5H5</accession>
    <name>A0A1W1I5H5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48181">
        <property type="protein sequence ID" value="SLM48181"/>
        <property type="gene ID" value="NSJP_2009"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2009"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="4"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="126" mass="13586" checksum="1C9C0367972646C3" modified="2017-06-07" version="1">MVSRYGPRVPVVGQAVLAGSHTSCEGRVLDLSVPGCLIECPHRLHVGEYVRLRVSLPDGGAAMTVSLAAVRWVCGNRVGLEFIRSSNADQHRLNAFVSRHDPRSAVPMGRVLKWKESITLLGASGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Q4</accession>
    <name>A0A1W1I5Q4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2166"/>
    <dbReference type="EnsemblBacteria" id="SLM48338">
        <property type="protein sequence ID" value="SLM48338"/>
        <property type="gene ID" value="NSJP_2166"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2166"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="162" mass="17652" checksum="EA1661937350AFE5" modified="2017-06-07" version="1">MNGSSSPSYPHVHQINVSDGGIPKHPLLEAFVGKDGLAGDAQRNRKLHGGPERAVCLYSLDLIERLQDEGHPIDPGSSGENLTLAGLEWSGLGPGAKLRIGPEVELEIASYCAPCELNAQWFRDRDISRIHQNNNPGWSRLYARVLQSGVVRPGDAVEILKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5S9</accession>
    <name>A0A1W1I5S9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48378">
        <property type="protein sequence ID" value="SLM48378"/>
        <property type="gene ID" value="NSJP_2206"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2206"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="2">
        <location>
            <begin position="65"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="470" mass="53203" checksum="9E06DA33C1BC124E" modified="2017-06-07" version="1">MKRAGIAIVGILALIVLLVRTVDWEFARPTMNAPLPKWHPEYGYRFANLPPTVDRNSDSLFIIASFSGGGARASALSYGVLKELAKTPIVWEGYRKRLIDEVTMINALSGGSFTAAYYALYHDRIFRDFESRFLRKDWESELRARILRSPSNWIRLWSPYFGRAHIFAELLDEALFDGATFNDLASSDQRPIVILHASDMATVSRFEFNQRQFDLICSDLSQLHLSVATASSSALPMVLSPISLKNYAGQCGFDPPRYLLEDNRNPNGRTRRNELRSYLDSEARPYIHLLDGGLADNIGMRGVLELSALVDDIESSLELLGAKKIKKLVYLMVSAETMPDLNHYKLDEIPSLTRALNALIDIPINRYSDDTFKLMRQAVSEWRIQLRNRVRTEGGVFTPDVEIYFINASLSELEDPDEQARLMRIPTNLALSGSEVDHLISAASKLLRNDKEYQRLLRDLETEAGKGIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5T7</accession>
    <name>A0A1W1I5T7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_2216</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48388">
        <property type="protein sequence ID" value="SLM48388"/>
        <property type="gene ID" value="NSJP_2216"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2216"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007891">
        <property type="entry name" value="CHASE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05227">
        <property type="entry name" value="CHASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="215"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="458"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="698" mass="76841" checksum="4C593BBAFD75B791" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5X7</accession>
    <name>A0A1W1I5X7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2256"/>
    <dbReference type="EnsemblBacteria" id="SLM48428">
        <property type="protein sequence ID" value="SLM48428"/>
        <property type="gene ID" value="NSJP_2256"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2256"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="212" mass="23487" checksum="237C3A2FE33F4E52" modified="2017-06-07" version="1">MSILIVDDSSDQRALLSSILDKAGHTDILCADSAKSAWKLLDPAARGTDPRVDLVLMDVLMPEQDGVEACRQIKTCADLRDVPVIMVTADNDLSNLKAAFAAGANDYINKPVQSVELLARVSSALALKQETDRRKAHELELQRSNEELQRALREVKVLRGLIPICASCKKIRNDGGFWQQLEEYLSQHSEAEFSHGLCLPCIKRLYPGVYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I631</accession>
    <name>A0A1W1I631_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Branched-chain-amino-acid aminotransferase</fullName>
            <shortName evidence="17">BCAT</shortName>
            <ecNumber evidence="17">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">ilvE</name>
        <name evidence="18" type="ORF">NSJP_2111</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 17">Acts on leucine, isoleucine and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 17">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 17">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 16">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6 17">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 17">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 17">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 15">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="17"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2111"/>
    <dbReference type="EnsemblBacteria" id="SLM48283">
        <property type="protein sequence ID" value="SLM48283"/>
        <property type="gene ID" value="NSJP_2111"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2111"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005785">
        <property type="entry name" value="B_amino_transI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01122">
        <property type="entry name" value="ilvE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17 18" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="14 17" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 17 18" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00003109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU364094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SLM48283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="303" mass="33653" checksum="D9138B12088041FB" modified="2017-06-07" version="1">MEPQGKIWMDGAFVDWADANVHVLTHSLHYGLAAFEGLRCYRGKSGSAIFRLHEHVDRLFESAHIAMMTIPYDKKQVAEAIVETVRINKLDACYIRPLVYIGYGAMGVYPGDNPIKLAVAAWKWGAYLGDDALANGMRARVSSFTRHHVNVSMTRGKISGYYVNSILAKREAKADGYDEAIMLDPEGYVSEGTGENIFIVRKGRIKTTPLTSILEGITRNSVIELAREQGIVVQEDRFTRDEMYIADEVFVTGTAAELTPVREIDNRRIGNGKPGPITAALQKAFFSVVRGEDAAHASWLTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I636</accession>
    <name>A0A1W1I636_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48460">
        <property type="protein sequence ID" value="SLM48460"/>
        <property type="gene ID" value="NSJP_2288"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2288"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023974">
        <property type="entry name" value="HxsD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03976">
        <property type="entry name" value="chp_LLNDYxLRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="109" mass="12481" checksum="C3870EF81EEDC2EA" modified="2017-06-07" version="1">MGHDQPTRTLTFDKNVYSVTAVKQAAYRYLDRFTTDITTEADEIRCSLTFKATVTEENAQRLINEFKNEVLDQDLRERLKAETEGVRNLILAHAFSKTGLIDNESFPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I656</accession>
    <name>A0A1W1I656_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48480">
        <property type="protein sequence ID" value="SLM48480"/>
        <property type="gene ID" value="NSJP_2308"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2308"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="74" mass="8443" checksum="4C7BC050AFAEF821" modified="2017-06-07" version="1">MGLRRNKKDGADSVQEIPAHQLIAHFMSASVPLEQYLQRGKPLTLQEIDLISLTVMGLQTFIEVWKRKKSIPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6N1</accession>
    <name>A0A1W1I6N1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48635">
        <property type="protein sequence ID" value="SLM48635"/>
        <property type="gene ID" value="NSJP_2463"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2463"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="145" mass="16111" checksum="56268D21FA9059AB" modified="2017-06-07" version="1">MSAPTSPGWSEARTKLNETFPQFYELEPGGALALDLGADGWLLELKPEGKVLCQYGVAMDDIMSLMSDGTPEDLGTDEIAKQAKYFIQPAVSKFRSLLLQSGFSEQSEMNDEYVAVTFERPVDFHNLSKVEDLIRWCRRQIGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6P2</accession>
    <name>A0A1W1I6P2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48601">
        <property type="protein sequence ID" value="SLM48601"/>
        <property type="gene ID" value="NSJP_2429"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2429"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="42" mass="4567" checksum="C3FFF69C58C93487" modified="2017-06-07" version="1">MKTNGTVTATYSYDSNGNRLSLVMPSGTTNGTYDAQDRLTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Q3</accession>
    <name>A0A1W1I6Q3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2508"/>
    <dbReference type="EnsemblBacteria" id="SLM48680">
        <property type="protein sequence ID" value="SLM48680"/>
        <property type="gene ID" value="NSJP_2508"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2508"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="49" mass="5825" checksum="1B858E69532E1FBF" modified="2017-06-07" version="1">MIRKLASGGYRLYSRKKDPKTGKRRNLGTFTTRAAAEKHERDVQYFKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6V4</accession>
    <name>A0A1W1I6V4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Activator of Hsp90 ATPase 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2563"/>
    <dbReference type="EnsemblBacteria" id="SLM48730">
        <property type="protein sequence ID" value="SLM48730"/>
        <property type="gene ID" value="NSJP_2563"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2563"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="148" mass="16586" checksum="4CCCC4C675C86321" modified="2017-06-07" version="1">MGSNTIRLHRVFRSTPERIYKAFLDADAMTKWLPPNGFTAKVHHMDAKVGGTFKMSFTNFTTGKSHSFGGKYLELVPHERIRYTDQFDDPNLPGEMRVTVTLKNVSCGTDVNIAQEGVPEVIPVEACYLGWQESLILLGKLVEAEIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I783</accession>
    <name>A0A1W1I783_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_2693</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2693"/>
    <dbReference type="EnsemblBacteria" id="SLM48860">
        <property type="protein sequence ID" value="SLM48860"/>
        <property type="gene ID" value="NSJP_2693"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2693"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="363" mass="39632" checksum="F58E4F62CAAD7CA3" modified="2017-06-07" version="1">MDVALTVPVPQAAKRLNLFERYLSLWVVGCMLMGVGLGRAFPGIVQHLRSLEVGEGSHINLPMALLIWLMIVPMMMKVDLASLRLVGQRPTGLFVTLVVNWLVKPFSMALFAWVFFRYLFAAWMTPSEAEQYIAGCIILAAAPCTAMVFVWSYLTDGDPAYTLVQVTVNDLLMPVLFVPIIGLLISGASSLSVPYAVLWYSVLAFVVIPLTIGTLLRAWLMRQYGARWFTDDFLPRFAPVTIAALLLTLVLIFAFQADNILTNPWHVALIAVPIVLQVYLNAALAYGLMQRLGVPYAVAAPGSLIGASNFFELAVATAIALFGPESGAALATVVGVLVEVPVMLSVCGICTRTRHWFPLKQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7B6</accession>
    <name>A0A1W1I7B6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48912">
        <property type="protein sequence ID" value="SLM48912"/>
        <property type="gene ID" value="NSJP_2745"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2745"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="122"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="304" mass="34763" checksum="3443B2956DD11E71" modified="2017-06-07" version="1">MDSLSGDSGYSGAMAARPNRRSFHKAQGRRTGLRRRLARIRRFLQARWNEFQLMRAALAAAPFPFRLIVGGLLLLLIWSTVNWTYHAIHKPTELFFPLDDTLDKNPADTWRQYKSLFVKHSTSIITPELLAALAQLESGGNPVARTYWRWRLTWNPLGVYRPASSAVGLYQITDGTFQEAKRYCIHNHQVVEEGPWHDLRSCWFNEFYMRVWPTHAVEMTAALLDRRVTQILGARRFAAVSLRRKQELAAVIHLCGAGAGREFVARGFRLTSRQRCGDHDVRHYVARVSILMREFAKLAAGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7G9</accession>
    <name>A0A1W1I7G9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trpH</name>
        <name evidence="2" type="ORF">NSJP_2642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2642"/>
    <dbReference type="EnsemblBacteria" id="SLM48809">
        <property type="protein sequence ID" value="SLM48809"/>
        <property type="gene ID" value="NSJP_2642"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2642"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="281" mass="30541" checksum="D2FDCC9FA5FA4ED3" modified="2017-06-07" version="1">MSRIDLHLHTTHSDGSYRPSEVLTRAKAASVTALAITDHDITSGLPEAMTTGEQLGIEVVPGVEISSFDGKSELHILGYYIDWQNPLFNDRLASLRASRHRRNPLIVERLRAAGLDVTYEEVQALAGTDAVGRPHIAQLLMSKGYVTSAKEAFDRYLAEGRPAYVARELPHPAEAISWIREAKGLAVLAHPTWVRTAGSELASCVATLKDQGLAGIEVHYSTHTKAQTTAYLNLSRQFNLLVTGGSDFHGVTKPDIEVGTGRGDLKVKPDLLAAMKEAAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7J1</accession>
    <name>A0A1W1I7J1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48773">
        <property type="protein sequence ID" value="SLM48773"/>
        <property type="gene ID" value="NSJP_2606"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2606"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="120" mass="13385" checksum="B2FFED501B1BAFB6" modified="2017-06-07" version="1">MKFLLIVHHHEDTFMNMEQAERQRLLDESIALTHQLHGVGQYVHASPLQPSGTAILVRVRQGKPVVTDGPFIETREQIAGYFLVDARDLEEAVDIAGRVPGARIGTVEVRPLIEITGLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7N7</accession>
    <name>A0A1W1I7N7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49027">
        <property type="protein sequence ID" value="SLM49027"/>
        <property type="gene ID" value="NSJP_2860"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2860"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="269" mass="30019" checksum="7DCCE30231330A54" modified="2017-06-07" version="1">MHRTTSMTMNHSAWHAGLIILLLCLTGCPGSVYLWEVRTESTRKPPEFSVAMLKHERVGILEALTSPGLHGNEVGLALSLKRVVERVSPTMVLVPPLEAASRINRAGLTPEYTRMRMDYEQSNILDRDPLKKVGQALGVRYVLQPRLAAFTQTLYDRWKVPALEINVIRIRSSILRLSLQIWDTETGDLVWASTAEGSFQEEALTEDPVYLREAGRITWGSIVSDFARDRTSSRYSPTNNLVDSLIGPDEIDEEPPNEPTGTPAAPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7T3</accession>
    <name>A0A1W1I7T3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Cysteine desulfurase</fullName>
            <ecNumber evidence="4 6">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_2814</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4 6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2814"/>
    <dbReference type="EnsemblBacteria" id="SLM48981">
        <property type="protein sequence ID" value="SLM48981"/>
        <property type="gene ID" value="NSJP_2814"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2814"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="230"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="609" mass="65095" checksum="03ABFBFD9B739091" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7W0</accession>
    <name>A0A1W1I7W0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative general secretion pathway protein K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_2726</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GSP K family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2726"/>
    <dbReference type="EnsemblBacteria" id="SLM48893">
        <property type="protein sequence ID" value="SLM48893"/>
        <property type="gene ID" value="NSJP_2726"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2726"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005628">
        <property type="entry name" value="GspK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038072">
        <property type="entry name" value="GspK_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38831">
        <property type="entry name" value="PTHR38831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03934">
        <property type="entry name" value="T2SSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002786">
        <property type="entry name" value="XcpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158544">
        <property type="entry name" value="SSF158544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="315" mass="35032" checksum="182057D6E9D5DAE4" modified="2017-06-07" version="1">MSRSDERGVALLLALLVLTLLVALILEFDSEARREYRDAAAFRDGFKATVLTRAAVQAAKAVLQQDFLKDRQAGQFYDAPTDLWAFPIQQYPIGDGILTAQIEDERGKLNLNDLAAGGDPNARKSKVTRVKRLFDLMQISPEIVDAIVDWIDADDTPEPAGAETLYYQSLHPPYRAANAPLQTLGELRLVKGMTAESFDKISRYVTVFPQEGEGRLNLNTAESIVLQSLDPRVSQAVAGEIIQGRPYKTLQELDRVSSFEAVGKELRLQNVYDIKSEVFSARMTLTVNEVVKHAIVTLRRDANTGTSAVLYYRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I856</accession>
    <name>A0A1W1I856_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Chymotrypsin</fullName>
            <ecNumber evidence="3">3.4.21.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.1" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3017"/>
    <dbReference type="EnsemblBacteria" id="SLM49184">
        <property type="protein sequence ID" value="SLM49184"/>
        <property type="gene ID" value="NSJP_3017"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3017"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="80"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="465" mass="48817" checksum="503450C771A426B9" modified="2017-06-07" version="1">MISIPRRNRSIESYLSAVIVITGLASGCVGQPSSSSPSAGDPNAVQERAVSRAQLDTGRVPSKTAQPTAPSAPTPIVLPPTGGKFEPDYRYPWVVSVQSRLTCKGVLLDPRWVLTAAHCVQISGATVTYTRTDPYTGQSRSETRQAGSGSGGIYSHEQYSSSSSDQLNDIALIRVTQPFSITPYLQTVGLPRDSRRQGVVGTVANFSHNLNTPAGQFAIFRAPIGPDSFAPKFYITAAAANASLCEGDSGSGFVTVEYGRATVRGIASQGTVSDCKTPTGEATFTDVYNFRGWILQKMGMNDAALTGNTRLRWSGSSARGTMVVACFNPSGGNVVGPLNVVGVEEGAVCEPGQTQTVMCVLDKNQTATKFGPPQLTGFTMRTTTANGSQVQSLPISGNTASFFGLLPPGTSREFTCQVSSGLVAATGAMTGTNMAVMSRGVEKDQVEEPEIVQPSPFDPTDGTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I870</accession>
    <name>A0A1W1I870_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdenum-pterin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mopII</name>
        <name evidence="4" type="ORF">NSJP_2836</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2836"/>
    <dbReference type="EnsemblBacteria" id="SLM49003">
        <property type="protein sequence ID" value="SLM49003"/>
        <property type="gene ID" value="NSJP_2836"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2836"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00638">
        <property type="entry name" value="Mop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mop" evidence="3">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="67" mass="7081" checksum="9817974604D3483E" modified="2017-06-07" version="1">MKLSARNQFQGTVVRITDGQAMAEVVVKVGQLEFVAAITEGSVKSMGLKVNDTVTVAVKATEVMIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8A2</accession>
    <name>A0A1W1I8A2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl hydrolase (Glycogen debranching enzyme)</fullName>
            <ecNumber evidence="5">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glgX</name>
        <name evidence="5" type="ORF">NSJP_2866</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2866"/>
    <dbReference type="EnsemblBacteria" id="SLM49033">
        <property type="protein sequence ID" value="SLM49033"/>
        <property type="gene ID" value="NSJP_2866"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2866"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="159"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="722" mass="81767" checksum="7A993B4985985A14" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8C9</accession>
    <name>A0A1W1I8C9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49245">
        <property type="protein sequence ID" value="SLM49245"/>
        <property type="gene ID" value="NSJP_3078"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3078"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="138"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="269" mass="30185" checksum="3AD453342A396245" modified="2017-06-07" version="1">MPVVVTATGDEREFARRTLLRGAFDLITLPVDREQTVRTVRLALWHSTLRTLIARKDLALATYQDHMDKYPREREQFEESFTKALALVEETIASVKGTILQLDESLVCFSDFATQVEHHVRQRALNRLGPVSGPAPTTVLLIDSQKEDREYWAQCLKTRSPGCIVLEAETGKAGLDLCRSQRVDCVVMELNLSDMSGFEVLWNLVPQAQHPRRPVVVLAKTVFAPMRQLALNNGARAYLVKGRTSGEELDRTIRTAIAMVKPTGTDLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8F9</accession>
    <name>A0A1W1I8F9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative 2-octaprenyl-3-methyl-6-methoxy-1, 4-benzoquinol hydroxylase</fullName>
            <ecNumber evidence="1">1.14.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.14.13.-" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3108"/>
    <dbReference type="EnsemblBacteria" id="SLM49275">
        <property type="protein sequence ID" value="SLM49275"/>
        <property type="gene ID" value="NSJP_3108"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3108"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="132" mass="14754" checksum="E6071813E533D3BE" modified="2017-06-07" version="1">MNPHASQGRMQAMVDAMTLSDLIPDCLRDGDCSAERLRACEAARRPHVTLLQRLADQQVFYWNTGNPGVAFLRDRVFRTLNRNARLRYQVLSTTAGLQMTEPFTLLDRVIAAGFLPDFRAGHRPAIPQNGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8I2</accession>
    <name>A0A1W1I8I2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3165"/>
    <dbReference type="EnsemblBacteria" id="SLM49332">
        <property type="protein sequence ID" value="SLM49332"/>
        <property type="gene ID" value="NSJP_3165"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3165"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="57"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="162"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="355" mass="40483" checksum="59A7CCF0739CA641" modified="2017-06-07" version="1">MESPDGNSLVLASGVAGARKKRWKVGCLNKTMAREMEAAIKTRILLGQEKSMYAKPVLFKEWASIYLDLEEVKSLRSIEGRTHSVQAHLIPFFGRKLLSEIKPQDVESFRSQRRKNNGKPASIQTINHDHVALKHCLNVAIRRGILQSNPASKVPMPNPHNERDRVLTETEWVNLYQVAKSHLKPVLVIAYQLGQRFSEIVSLTWDRVDLRRGFITLRRGDTKTRVARQIPMTPDVQRALQRLAKARSLASRYVFTYKGRPLKRVSRSFTTALKSAGITDFRFHDLRHCASTNMRRAGVDTATAMKIVGHKSEKMWKRYNAIEERDLTQAAQKVHKYLEENTPGTLEECAANSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8J0</accession>
    <name>A0A1W1I8J0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="SLM49113"/>
        <property type="gene ID" value="NSJP_2946"/>
    </dbReference>
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        <property type="component" value="Chromosome i"/>
    </dbReference>
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            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="396" mass="44873" checksum="87EEB867623FA7D2" modified="2017-06-07" version="1">MSTATSPLTPSLIESVIDAMPIQGRIMLHLILLQHFDVSDEEINYMTMDRPDPRCVAGSKPTYNILTQEAVKAVRDKRDQYLRQVRLKRERTWLQCECLTTLSRLRELMAERAAHLLTTRFNLPSEALEALQAQARTTVNRPAIRMLDQRWEAQEIQLEDYQQQRLGIEMQVQLRLAERYRKRLALAARERQTADYQPLQDHEIAHIWGIPAGSLAARKVKHMTAYLQGLQAALQGSAAKTGQTSPPLDLWRETFTVLAIRPVQRSVSTYDGLERTEANLIEKLVSLTSGVVGEDVETKFWLSLVHGASSNAVLSEVTRNLFGLQRLAAILGDTDASPESIDDMLLARVTPKPRDEEEEAKLLEKKPTDPANDMREHVLKSMFGEQHTDLYGGGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8K0</accession>
    <name>A0A1W1I8K0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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        <property type="gene ID" value="NSJP_3167"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3167"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008023">
        <property type="entry name" value="DUF748"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05359">
        <property type="entry name" value="DUF748"/>
        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="897"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="987" mass="108149" checksum="88B2A12051E3ECC6" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8P2</accession>
    <name>A0A1W1I8P2_9BACT</name>
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        <submittedName>
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        </submittedName>
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        <lineage>
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                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="protein sequence ID" value="SLM49291"/>
        <property type="gene ID" value="NSJP_3123"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3123"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="83" mass="9358" checksum="D86EE54B43EA7A93" modified="2017-06-07" version="1">MPGIMMSLTVDGLPVRRPLVELVQEPFDRRRFQHEMRGGGKKCRDLCRVGYDMQGPPSVQVLSGDIESRKECAKTKSGERNVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Q2</accession>
    <name>A0A1W1I8Q2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">NSJP_3134</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 2" key="1">
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            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49301">
        <property type="protein sequence ID" value="SLM49301"/>
        <property type="gene ID" value="NSJP_3134"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3134"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="169" mass="18867" checksum="E41D1D1FCFDC0AE0" modified="2017-06-07" version="1">MPKKSASTKKTGITRNWIAYLCEALVTSGSMPTWEAATYLTEHLFGEKPNPRLLGTTNAFEVTVQFLRRMYHPLVEAASRDVTLPQGAQLHVFTDVSLTGKSAVLVVYFPADRHPHQLLMVDAVKAWELVFADSEEFNRWAEERYRTVKSGLSSAVGKPARQSLLAEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8T9</accession>
    <name>A0A1W1I8T9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49424">
        <property type="protein sequence ID" value="SLM49424"/>
        <property type="gene ID" value="NSJP_3257"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012777293" evidence="1">
        <location>
            <begin position="23"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="141" mass="15194" checksum="1A3D7EA4EB528A68" modified="2017-06-07" version="1">MKLAYMAVVAMVLVASAQAAQAESFPLLPGYYEVAVSGGPSSEMRNRCVTAEHLADPDSVLNYAFAKKYRPVPGFTVSNLSVQGGKITYDVETPNSTVHVDGMVSATQFAVKRHAKSKKSGTEIPIMTLDGKRTRDCRHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9B0</accession>
    <name>A0A1W1I9B0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">NSJP_3226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 2" key="1">
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="SLM49393.1"/>
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    </dbReference>
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        <property type="protein sequence ID" value="SLM49393"/>
        <property type="gene ID" value="NSJP_3226"/>
    </dbReference>
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        <property type="component" value="Chromosome i"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="101" mass="11215" checksum="543218ACDCBD2972" modified="2017-06-07" version="1">MDELEEKANTLFTGKTSQLAASHNHIRCTVDGCLQHATVACEVAVKNSHLGPDGEIHHIPLCSNHAQAGDTLRWEWRRDPDASATRKLRLDNLFALDTVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9B1</accession>
    <name>A0A1W1I9B1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3302</name>
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    <organism evidence="1 2">
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        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49469">
        <property type="protein sequence ID" value="SLM49469"/>
        <property type="gene ID" value="NSJP_3302"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3302"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="57" mass="5665" checksum="679378788ABA8720" modified="2017-06-07" version="1">MGPSPVEILISPAVSSASSVAIVAAEIGRTANAKPAANVAVTKPRRVMAGDEFGMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9E3</accession>
    <name>A0A1W1I9E3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3256"/>
    <dbReference type="EnsemblBacteria" id="SLM49423">
        <property type="protein sequence ID" value="SLM49423"/>
        <property type="gene ID" value="NSJP_3256"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3256"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="268" mass="30735" checksum="BC559266B1221C08" modified="2017-06-07" version="1">MREDLAKVVVTDAYRRAVDAINKHSFVLLIGEPAAGKTTIASLLAMAALDQWNAPTLKLDDPGKVAEHWNPDEPSQFFWLDDAFGVTQYEDFLVHRWNHILPQIRPMLRKGAKIVMTSRDYIYNRARRDLKGSAFPLLKESQVVIDVHDLSADEKRQILYNHLKLGKQPHSFRVDIKPYLEGVASHPRFIPETARRLADPLFTRDLFIDQYYVGQFVERREQLLQDILQGLDTDSKAALALIYMRNGHLESPVELQPSEAHALERLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9E7</accession>
    <name>A0A1W1I9E7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_3501</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49668">
        <property type="protein sequence ID" value="SLM49668"/>
        <property type="gene ID" value="NSJP_3501"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3501"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012912926" description="PNPLA domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="51"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="296"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="469" mass="51861" checksum="631C3569A5FC3733" modified="2017-06-07" version="1">MTRRFSAVLCVAVASLAGGCFGSPVYTAPRSLTASSCLSAPADTEQLVGLAVSGGGSRAALFAAGGMEALAKLRVGSDRQSLLKHISYVSSVSGGSLASAYYTLKKPPRDLPILAPDGELSPEYQQFFTQFEKIMSLDFEGPLLRRQIFRLRWFNPAWAAKSLGEILREDYLGDATFQDLMHRQVQGDVPYLILNTTLYNSGRRFTLSTLPAEYSRYDLFHSLALPEDSQRESPLVSDALKARWESLISVTPQDLELDHCQIQVATAVAASMSFPPLIGPITFRIEGQDLYWHAGDGGLSDNTGIESLAMVFLKKIRAGKIRRGLIIALDSSFPFDVGGERLNSFGEGFSLFSYDYSRIPTIMEERVAAYRALFLNSAQREGLLPGVEKLLLVRVRHTDAQWSDDLSDLPESCRKEDPTLTTSRAVVERLGKIVTRLWLDSPCERDLVVTAARKVVMQKEPMIRAFLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9H6</accession>
    <name>A0A1W1I9H6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RND efflux system, outer membrane factor lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ttgC</name>
        <name evidence="4" type="ORF">NSJP_3286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3286"/>
    <dbReference type="EnsemblBacteria" id="SLM49453">
        <property type="protein sequence ID" value="SLM49453"/>
        <property type="gene ID" value="NSJP_3286"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3286"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="218"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="480" mass="53424" checksum="24A24A727C681852" modified="2017-06-07" version="1">MRDVMLRSFLVGLLGLLVSCKMGPDYARPAIPVSDSFRMAEEEKNLQSFANVPWWDLYRDEELQKLIRLALEGNKDLKRAVATVDEFAARVLVTRTDFAPQMNVAVNAPGFGNTRNLSFPGFPNLFNYYVQGNLAWELDIWGRIRRSNEAAIGDLLSREENRRGIILQIVSGVAQAYFELRQFDLQRDIALRTLDAWDESVRIARARFKQGYIHRLDVEQFEAERENAAARIAELKRQIVQKENELSVLLGRNPHQISRGRALTEQVMPPVVPAGLPSELLQRRPDVVQAEQQVAAATARIGQAKADRFPKLSITGILGIASPQLTQLVAHETFFGVAGPSVAGPLLNAQVLGFQQEAAEAQARQTVAQYEQTILVAFREVEDSLVAVSTADEQVAAQARQVKALQAALHLANLRYKGGIANYLDVLIAQRNLFDAELSLASTRRLHLVSVVQLYKALGGGWLPAPATESQESEQHARME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9I5</accession>
    <name>A0A1W1I9I5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49652">
        <property type="protein sequence ID" value="SLM49652"/>
        <property type="gene ID" value="NSJP_3485"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3485"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="125" mass="14031" checksum="FF93405454945C78" modified="2017-06-07" version="1">MSKSARIMIVEDDRCIGESMQDRLQSLGYDTVLMTDGYSALATMALEHHRSPVQLVLLDLRLPGMDGMLVLGELRKIYPEIPVIMMSATAERADSLEAIKAGAQDFLAKPIDPRMLEEKCRKMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9M9</accession>
    <name>A0A1W1I9M9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49503">
        <property type="protein sequence ID" value="SLM49503"/>
        <property type="gene ID" value="NSJP_3336"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3336"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="225" mass="24137" checksum="978ADD724447A2EE" modified="2017-06-07" version="1">MAIDDRSVSDVPLAGGTDRSGEPGPAAGEDCREGAGLDRPLAGTRVIHSLPGRVRLRVPALKSHSHLEKGLQALLSDQTGVIEATVNSRCQSVTVMYDPALWSLDSLCAFHRRLTREELERRASIALADEEGAATSPPTEWLQPWRFLTKTEENPHSSGAVQTQVRSGYWTAGYISMVVGAVLVPVPLVPGIPLLMLASYFFAKASVSKPGNGPEFDGHATKPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Q0</accession>
    <name>A0A1W1I9Q0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3484"/>
    <dbReference type="EnsemblBacteria" id="SLM49651">
        <property type="protein sequence ID" value="SLM49651"/>
        <property type="gene ID" value="NSJP_3484"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3484"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="42"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="217"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="403" mass="44631" checksum="5639C0740AA27677" modified="2017-06-07" version="1">MNGNSNCEATIASERGSDPCRSAARVLYLVNLNPSMKFGSLEEQIFLLSEGLSNRGGLLVPVFSRDPNESHGMRYRKAGLPVASLRLGRFRASALARLLRLADDHRVQVIHWNLYPPINPYVPLLKLLRPKIRHILTDHNSRPRSFVRSTNVLKRLSHKWFASAYSDVFAVSNYVHSDLLNQKVWKNPRRYYHFVNTDRFKPDVETKKVVRASLGCERRFVMLVVAHLIPEKGVDAALRALALLPSHVSLWIVGDGPEREKLEQLVESLGVGERTTFLGLCADVCRYMQAADCLICPSLWEEAAGLVILEAMASGLPVIASYVGGIPEFVRSGQNGFLVAAGDYSAVARHVAALAECRPLLNEIALAARGDAVARFSHETRVPQALSLYDTQTSDAGKVEHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Q8</accession>
    <name>A0A1W1I9Q8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmB</name>
        <name evidence="5" type="ORF">NSJP_3558</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3558"/>
    <dbReference type="EnsemblBacteria" id="SLM49725">
        <property type="protein sequence ID" value="SLM49725"/>
        <property type="gene ID" value="NSJP_3558"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3558"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="63" mass="7083" checksum="0F3ABE4A8A3BA1E9" modified="2017-06-07" version="1">MAFACDICLKRHQTGNNVSHANNKTKRSFNPNLQRVRAIVDGSTKRIRVCTRCLRSGLVKKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9V8</accession>
    <name>A0A1W1I9V8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49772">
        <property type="protein sequence ID" value="SLM49772"/>
        <property type="gene ID" value="NSJP_3605"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3605"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="115" mass="13230" checksum="E0FA66965C90B263" modified="2017-06-07" version="1">MFVEDRGDVRFRDFGIPGAIRIHDDRWALLAGAEAGRPADQHFPRHDATLHQAHIERHEQLRRALAAAGGFWVTRRPGVGADDDVIFRLRHECSFFKIEWRMARTAVRPPACYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9W6</accession>
    <name>A0A1W1I9W6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49796">
        <property type="protein sequence ID" value="SLM49796"/>
        <property type="gene ID" value="NSJP_3629"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3629"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="63" mass="7301" checksum="70D8D99B15784ACB" modified="2017-06-07" version="1">MPKPGEAKPKLLRLSSFSRPTSLAYASKWEFHNLRRDPVAQGIDTRQFHDGTLSDFVRYYLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAD5</accession>
    <name>A0A1W1IAD5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative LmbE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3817"/>
    <dbReference type="EnsemblBacteria" id="SLM49984">
        <property type="protein sequence ID" value="SLM49984"/>
        <property type="gene ID" value="NSJP_3817"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3817"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="229" mass="26491" checksum="517F3AD841BAC6F9" modified="2017-06-07" version="1">MGSVEKERLSPMLLSSLETANKPGITVLCLGSHPDDIEIGCGGTIIRLVETFPQISVGWIVFSAGRRRRSEAEASAADHLRGVPRKTVSVRTFRESFFPSQLAAIKKEFERLKRDWDPDVIFTHYRHDLHQDHRIISDLTWNTWRRHLIFEYEIPKYDGDLGSPNVFVPLDKRIGETKVIHLMRHFATQRSKAWFTEDTFWAMMRIRGVEANSPTAYAEAFHCRKLVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAG7</accession>
    <name>A0A1W1IAG7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49990">
        <property type="protein sequence ID" value="SLM49990"/>
        <property type="gene ID" value="NSJP_3823"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3823"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="140"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="331" mass="37020" checksum="C18A8911502F00EA" modified="2017-06-07" version="1">MVGRRHARNLHRLGCQVSCMDTRPDPLEEIIKEVPVIHQFTSLNDALSRASEFTGVAVCSPTQCHVEQARAVLDLDLPVLVEKPVSTDVDSCNPLQTRLQQGGKLLLDYPYRWWTPVRQLKTLISAGAIGVPRHARFVMSAHAKHVNPVQAEQALSSAKHDLNGGVLLEQIHFIDLMLWIFGMPDRIFARTGKISNLEREADDVVDIVAGYADQVLVTFHMDSFGRPHEQHIVVTGEEGTIQCLFAPDALRLSRMPELRWETEYFSIERNDMFLSVAREFLNILDGNNFDQTCTLEDGIRTLKVVEACKQSQGTRSEVILTGTVPVADTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAI5</accession>
    <name>A0A1W1IAI5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50005">
        <property type="protein sequence ID" value="SLM50005"/>
        <property type="gene ID" value="NSJP_3838"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3838"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="234" mass="24497" checksum="FEFA57CE56C4C2D8" modified="2017-06-07" version="1">MNTFIEQALMAPLTVLAGYATAIFPNLIAMGILLLAGLLAARGVGFLAERLLRVLGFDHLCNRVGVTAALLRAGVKTDPSRLVGRGLHWTVVLVTGVAVVSALNLAPINQVAQSLLAYVPRLITASIILLAGYVASNFASQAILIAAVNAGLAPARLLATCSRWGLQLLAVAMALEQLGIAEQIVVVGFGITWGGLVLAAAIAFGFGATDLAKAFLEKKLLPTRTDVPDDLRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAY3</accession>
    <name>A0A1W1IAY3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-dehydro-3-deoxyphosphooctonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.55</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-deoxy-D-manno-octulosonic acid 8-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">KDO-8-phosphate synthase</fullName>
            <shortName evidence="6">KDO 8-P synthase</shortName>
            <shortName evidence="6">KDOPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyoctonate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">kdsA</name>
        <name evidence="8" type="ORF">NSJP_3978</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14053"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57693"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:85985"/>
            <dbReference type="EC" id="2.5.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the KdsA family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.55" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3978"/>
    <dbReference type="EnsemblBacteria" id="SLM50145">
        <property type="protein sequence ID" value="SLM50145"/>
        <property type="gene ID" value="NSJP_3978"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3978"/>
    <dbReference type="UniPathway" id="UPA00030"/>
    <dbReference type="UniPathway" id="UPA00357">
        <property type="reaction ID" value="UER00474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008676">
        <property type="term" value="F:3-deoxy-8-phosphooctulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019294">
        <property type="term" value="P:keto-3-deoxy-D-manno-octulosonic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00056">
        <property type="entry name" value="KDO8P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006269">
        <property type="entry name" value="KDO8P_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21057">
        <property type="entry name" value="PTHR21057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01362">
        <property type="entry name" value="KDO8P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="7">
        <location>
            <begin position="11"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM50145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="275" mass="29334" checksum="B3151E7D7F6C8990" modified="2017-06-07" version="1">MAHVVDIGAFKVGRGQPPFLIAGPCVIENEQLVLDTAGRIAEIARALGMPYVFKSSYDKANRTSIHSFRGPGIKKGLEVLAKVKREVGVAVLTDVHTESDATEAGTVVDVLQIPAFLCRQTDLLIAAAKTGKVVNVKKGQFLSPPEMGNAVKKLEECGNARIVLTERGSSFGYNNLVVDMRSFPILRSFGYPVVFDATHSVQLPGGGGTKSSGQREFVEPLACAAAGAGVDGFFMEVHPDPDHALSDGPNMVPLHQLKALLERVMRICDAANPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB03</accession>
    <name>A0A1W1IB03_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_4013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4013"/>
    <dbReference type="EnsemblBacteria" id="SLM50180">
        <property type="protein sequence ID" value="SLM50180"/>
        <property type="gene ID" value="NSJP_4013"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4013"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd14948">
        <property type="entry name" value="BACON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024361">
        <property type="entry name" value="BACON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19190">
        <property type="entry name" value="BACON_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="621"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="713" mass="70567" checksum="11D810C6D346525D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB23</accession>
    <name>A0A1W1IB23_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative tonB-dependent receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NSJP_3932</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50099">
        <property type="protein sequence ID" value="SLM50099"/>
        <property type="gene ID" value="NSJP_3932"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3932"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030149">
        <property type="entry name" value="FcuA/FatA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010917">
        <property type="entry name" value="TonB_rcpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF82">
        <property type="entry name" value="PTHR32552:SF82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07660">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01156">
        <property type="entry name" value="TONB_DEPENDENT_REC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="7 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6 10" id="KW-0798">TonB box</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="STN" evidence="13">
        <location>
            <begin position="72"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="537"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM50099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="852" mass="91520" checksum="8652AC63D2D4C0F9" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB42</accession>
    <name>A0A1W1IB42_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase FkbM family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4043"/>
    <dbReference type="EnsemblBacteria" id="SLM50210">
        <property type="protein sequence ID" value="SLM50210"/>
        <property type="gene ID" value="NSJP_4043"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4043"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="54"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="254" mass="28798" checksum="C73D01A4D95272DB" modified="2017-06-07" version="1">MILRTRQLLKRIAGPAFAPKVRLLLGMIDKNQFYDVLSYEVMKKCLKERSVCVDVGCHAGSFLRWMMEMAPKGTFFAFEPLPELYKRLSDSFTFPPVRVFNLALSDRADVVSFNYVVSNPAYSGLLKRRYDRPNETDCTITVPTDRLDSIIGEHDCVDFIKIDVEGAEFQVLRGGARTINRCKPIIVFEHGIGAADCYGTRPEQIYDLLCDECGLGISLLDGWLVGRQPLSRDGFCEQFNKGLNYYFIAHPVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB66</accession>
    <name>A0A1W1IB66_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_4075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50242">
        <property type="protein sequence ID" value="SLM50242"/>
        <property type="gene ID" value="NSJP_4075"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4075"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="63" mass="6849" checksum="0CAC9CCAF52D7E68" modified="2017-06-07" version="1">MAASCSLRAGQAAAQVGHIEMARSLFESVLEYRPQAEYAYYSLQAKAALLNLDNPAITVSLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB82</accession>
    <name>A0A1W1IB82_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enolase</fullName>
            <ecNumber evidence="8">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">eno</name>
        <name evidence="13" type="ORF">NSJP_4083</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell surface</location>
        </subcellularLocation>
        <text evidence="8">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4083"/>
    <dbReference type="EnsemblBacteria" id="SLM50250">
        <property type="protein sequence ID" value="SLM50250"/>
        <property type="gene ID" value="NSJP_4083"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4083"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="11">
        <location>
            <begin position="139"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="365"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 9">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="8">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM50250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="428" mass="46049" checksum="0510933C16E4893F" modified="2017-06-07" version="1">MSAIKEIRGRQIIDSRGNPTVEAEVVLESGARGRAAVPSGASTGEKEAIELRDGDKKRWLGKGVSKAVANISKSIAPELLGMEAFDQAGLDQTMIGLDGTKTKGKLGANAILGVSLAVAKAAAAETGQPLYRYLGGTNARVLPVPLMNIINGGAHADNRLDLQEFMIVPVGAEHFHEALRMATEVFHSLKALLKKKGLSTAVGDEGGFAPDLQSNEEALALIIQAIEEAGYQPGQEVALALDCAASELYDKNRYVLEAEKNRERSSEEMINYYGKLLDRYPILSIEDGLSEVDWKGWKMLTDKLGSRVQLVGDDIFVTNVEIFSKGIKEGIGNSILIKLNQIGTLTETLEAIELAKRSGYTAIISHRSGETEDTIIADVAVATNSGLIKTGSLSRTDRVAKYNQLLRIEEELGAAAVYRGRDAMPGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBB1</accession>
    <name>A0A1W1IBB1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_4098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50265">
        <property type="protein sequence ID" value="SLM50265"/>
        <property type="gene ID" value="NSJP_4098"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4098"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="192"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="509" mass="56463" checksum="79F6B38E445905EF" modified="2017-06-07" version="1">MIDHVCLIIPPSLFLLDERVFMSLGILKVAAVLEQEGVTVELLDLSGVSNYEEALAAHLEISPAQCFGLTATTPQMPAATSIHRTIRRLRPTARIILGGPHATLVCAAAKHERKRSVIGRAARAVKQLTGMFDVLVAGDGEFAVLEALQEAPAGIIDGDDPRSQRFLTHAALERLPFPARHLVDVSSYRFSIDGTRALSMIAQLGCPFGCGFCGGRTSPSLRRIRTRSPEHIVNEMVHLYQAYGVTGFMLYDDELNVNPKMVSLMSLIANTQQRLGIEFRLRGFIKAELFTDEQAGAMYEAGFRWILVGFESAHPRILDNIQKQATREENARCMDIARRHHLKVKALMSLGHPGESEETVQATRDWLVETGPDDFDATVITTYPGTPYFDEAVETSPGTWTYTCRGSQDRLHSVEVDYRHVAEYYKGAPGNYTAFVYTDYLTSGRLVELRDELETDVRAKLALPFNPADPGLRYEHSMGQGSLPPFILRASSPSTMRAGNRTLRILPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZK3</accession>
    <name>A0A1W1HZK3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase</fullName>
            <shortName evidence="7">UDP-N-acetylglucosamine acyltransferase</shortName>
            <ecNumber evidence="7">2.3.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">lpxA</name>
        <name evidence="9" type="ORF">NSJP_0018</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:67812"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="ChEBI" id="CHEBI:173225"/>
            <dbReference type="EC" id="2.3.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transferase hexapeptide repeat family. LpxA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.129" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0018"/>
    <dbReference type="EnsemblBacteria" id="SLM46190">
        <property type="protein sequence ID" value="SLM46190"/>
        <property type="gene ID" value="NSJP_0018"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0018"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008780">
        <property type="term" value="F:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03351">
        <property type="entry name" value="LbH_UDP-GlcNAc_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00387">
        <property type="entry name" value="LpxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029098">
        <property type="entry name" value="Acetyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037157">
        <property type="entry name" value="Acetyltransf_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010137">
        <property type="entry name" value="Lipid_A_LpxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43480">
        <property type="entry name" value="PTHR43480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13720">
        <property type="entry name" value="Acetyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000456">
        <property type="entry name" value="UDP-GlcNAc_acltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01852">
        <property type="entry name" value="lipid_A_lpxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_11" evidence="8">
        <location>
            <begin position="175"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="269" mass="29058" checksum="3662BD41B33DB284" modified="2017-06-07" version="1">MQIHPQAIVHPKAKLADDVAVGPFCVVGEHVTIGKGTKLFSHVSVEGWTQIGERCELHPFVSIGGPPQHLQYKGEPTRVVIGDDNILREYVTVNRATMQGGGETTIGSKNFLMAYVHVAHDCHLGSHLILANAASLAGHITIGDHAIIGGLSGIHQFVRIGAYSMVGGCCALGQDLPPFMRAAGGYRARMYGLNSVGLRRHGFSGERIAVLKRAYDLLFRSGHRTAEAAKLARTEFADQPDVMAVVTFLEGSKRGICRSVIHEQESEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZK8</accession>
    <name>A0A1W1HZK8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Fused lipid transporter subunits of ABC superfamily: membrane component ATP-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">msbA</name>
        <name evidence="12" type="ORF">NSJP_0014</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0014"/>
    <dbReference type="EnsemblBacteria" id="SLM46186">
        <property type="protein sequence ID" value="SLM46186"/>
        <property type="gene ID" value="NSJP_0014"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0014"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034040">
        <property type="term" value="F:ATPase-coupled lipid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011917">
        <property type="entry name" value="ABC_transpr_lipidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02203">
        <property type="entry name" value="MsbA_lipidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="22"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="338"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="372"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM46186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="580" mass="63860" checksum="CE52A665CFC00652" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZR5</accession>
    <name>A0A1W1HZR5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46248">
        <property type="protein sequence ID" value="SLM46248"/>
        <property type="gene ID" value="NSJP_0076"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0076"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="145" mass="16052" checksum="7419053FCC326779" modified="2017-06-07" version="1">MRRSSRTWLPDPNQNGRPASTRLQRAGDIISHIVNELIKYGLYFLLGGTIVSLSTYLGSQGRSFLAAFASTFPAITGATFLLIYLNGGTDSLVGYAKNLLWFVPPWIVYVISMIVVVPRLGFWPGAAMSLTLYMMCIAILKMTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZU7</accession>
    <name>A0A1W1HZU7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">tatA</name>
        <name evidence="9" type="ORF">NSJP_0108</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a complex with TatC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0108"/>
    <dbReference type="EnsemblBacteria" id="SLM46280">
        <property type="protein sequence ID" value="SLM46280"/>
        <property type="gene ID" value="NSJP_0108"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0108"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="51"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="90" mass="9345" checksum="19DF585E73120A0F" modified="2017-06-07" version="1">MFGSLGFTELILILFIVLIIFGAGKLPQLGEGIGKAIKGFKKSVHEAEAIEAEAQQATQQQAATPQQAIPSASPQAPVADQPAPQPVSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZW3</accession>
    <name>A0A1W1HZW3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46262">
        <property type="protein sequence ID" value="SLM46262"/>
        <property type="gene ID" value="NSJP_0090"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0090"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="57" mass="6408" checksum="7B2D126BF020308D" modified="2017-06-07" version="1">MSWQAITRPDRPADRTSDSVIPLQRQMYMSASQSIADYEKHSQYATAGPFCQVPFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZX0</accession>
    <name>A0A1W1HZX0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Preprotein translocase, subunit YajC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yajC</name>
        <name evidence="9" type="ORF">NSJP_0123</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0123"/>
    <dbReference type="EnsemblBacteria" id="SLM46295">
        <property type="protein sequence ID" value="SLM46295"/>
        <property type="gene ID" value="NSJP_0123"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0123"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="110" mass="12091" checksum="D88554B1DC3EFA1D" modified="2017-06-07" version="1">MWMASVAWAQGTAGGGSGASTILSLVPFVLVFVIFYFLLVLPQQRKQKQQRAMMDALKKGDKVITSSGVWGVVANLGKDTVTLQIADNTKIKIQREHIARLRADDDEKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I005</accession>
    <name>A0A1W1I005_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">tatC</name>
        <name evidence="7" type="ORF">NSJP_0166</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a complex with TatA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0166"/>
    <dbReference type="EnsemblBacteria" id="SLM46338">
        <property type="protein sequence ID" value="SLM46338"/>
        <property type="gene ID" value="NSJP_0166"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0166"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="311" mass="34313" checksum="FFB590E6CB0728A1" modified="2017-06-07" version="1">MLNDLNRWLQDSVFKPLEDKKMPVMEHLVELQVRLTRAVIVTALVFVGTFFYADTLVKWLRVPLQNMFVPGSLSWVPTDLPTVPFVFLAPAEALWQNVKVAGLFALVIATPYILFEIWQFVVPGLHAQERRFVGPFTFLSALAFYAGVGFSFFFVLPFALNFLVSYGVNAGFIPQLSIAQYVGFALWFLMVFGLIFEVPLAITLMAKLGWVDAPFLKRYRKWALLGSFIVAAVLTPTPDPFNQCLMALPMYVFYEVGIVSAGFFNKKKSAPAEPATVVAPAGSGHGKPMAPAMSGASGGDYVGVPSGGRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I032</accession>
    <name>A0A1W1I032_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46203">
        <property type="protein sequence ID" value="SLM46203"/>
        <property type="gene ID" value="NSJP_0031"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0031"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012258267" evidence="2">
        <location>
            <begin position="21"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="148" mass="15636" checksum="6D2C68CE5BCEC00F" modified="2017-06-07" version="1">MRRMLIGSLAVLLCGCAASLADIRKTTPTQSGTFPAPPATLAACVQQNVERVLSPYQINQVASPDQKEYYITATRHADGVAKEPLIAFDLFLVAFDNGSLVELREGASDGHSLTRRVWPIVESCAQKTSGANSPSPSASPATPAPLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I090</accession>
    <name>A0A1W1I090_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VanZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0215"/>
    <dbReference type="EnsemblBacteria" id="SLM46387">
        <property type="protein sequence ID" value="SLM46387"/>
        <property type="gene ID" value="NSJP_0215"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0215"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="28"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="136" mass="15347" checksum="D695D8428D4610A3" modified="2017-06-07" version="1">METSSEPFRQDAWLSQLWYWAPVFGYAALIFYFSAQSHPEEQLPQFLMREVSDKLLHAVEYAVLGILCYRGFRWAAGPAAARQAVLLSIAAASAYAVTDEVHQFFIPSREASSWDWVADVIGAAIGSISWSYFSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0A5</accession>
    <name>A0A1W1I0A5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_0254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0254"/>
    <dbReference type="EnsemblBacteria" id="SLM46426">
        <property type="protein sequence ID" value="SLM46426"/>
        <property type="gene ID" value="NSJP_0254"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0254"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="25"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="270" mass="29860" checksum="F396AE7E06EBF11B" modified="2017-06-07" version="1">MNIMTDGVYVRSEPGNGNLRQLIYLTGALALRDIKGRYRRSLLGITWAVLPPLFYTGVFWFMQSILAIPSPDAPYVVFAYSAMVLWSLFSSIVNRCGSCVSANAGIVKKIAMPYEVFPVSMVLIALFDFGVSFVLLGALLTWHHFPLGWSIVWLPVLIGLTVLCALAVGMLVAAIGTYAHDALFAVPLLMQVWLLVSPIMYPLSQVPERWKAVYLMNPMVGLIEGFRSVLIKNTAPDLTLLGLALVGTIVLLACSWPLFRYMAQYFADVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0B5</accession>
    <name>A0A1W1I0B5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0273"/>
    <dbReference type="EnsemblBacteria" id="SLM46445">
        <property type="protein sequence ID" value="SLM46445"/>
        <property type="gene ID" value="NSJP_0273"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0273"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010733515" description="FGE-sulfatase domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="46"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="284" mass="31166" checksum="87B5705750FAD0A0" modified="2017-06-07" version="1">MENGYRVGCCLAFVVVGLLSLAASPEPAKDGGATETKTVAARDGAPMILIVPGAFKMGSQDGLPNERPEHQVQLDGYYIDQYEVTMSLYRKFLESGKHDSPPTWDDEAATTVGDRPAVGMRWADAAAYCEWAGKRLPTEAEWEKAARGTDGRRYPWGHMQPFVDIANYNRGVWVNETVTLVPVTSGLEGMSVRHGLKTGGKSPYGLAHMAGNAAEWVSDWYDREYYQQSPEKNPTGPSKGEKRVIRGGSWADLPPALRVTARFSAEPEFEDRAIGFRCAMAADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0G0</accession>
    <name>A0A1W1I0G0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0318"/>
    <dbReference type="EnsemblBacteria" id="SLM46490">
        <property type="protein sequence ID" value="SLM46490"/>
        <property type="gene ID" value="NSJP_0318"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0318"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011577">
        <property type="entry name" value="Cyt_b561_bac/Ni-Hgenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01292">
        <property type="entry name" value="Ni_hydr_CYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Ni_hydr_CYTB" evidence="3">
        <location>
            <begin position="20"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="280" mass="30940" checksum="238682DF9A6824CD" modified="2017-06-07" version="1">MEQPPPAQGAAAPGVETVYRHTIPVRISHWLNAVCLFVLIMSGLQIFNAHPALYWGDRSDRDKPLLSIRPMRADNGEIRGVTTVLGHRFDTTGVLGYSDGRGRAFPAWATLPGPQWLAMGRRWHLFFAWLFVLNGLLFAAYSVVTRHFRLDLLPTTRDVGSIGRVVKDHLVLRHPKGDAAKHYNVLQKIAYLVVIFGLAPVIVLTGLAMSPTIDAAVPWLVTGLGGRQAARTLHFVACFAFVAFIVIHVTQVVITGFMNNIRSMTTGWFVVEREGASHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0L8</accession>
    <name>A0A1W1I0L8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Amine oxidase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0231"/>
    <dbReference type="EnsemblBacteria" id="SLM46403">
        <property type="protein sequence ID" value="SLM46403"/>
        <property type="gene ID" value="NSJP_0231"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0231"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="442" mass="50425" checksum="A85183958946731D" modified="2017-06-07" version="1">MIVIVGAGLAGLSTAYHLSGLPYRIYEREQDVGGLCRSYRKDGFTFDYTGHLLHFRQAEIKALVERLLAGRLQQHGRKSFIYSHQTYTEYPFQVNTFGLPPEVIRECLMGFIATLTQPVASIAPKDRSFKQWILDNLGDGMAKHFMVPFNEKLWQVSLDELTSDWVSWLVPKPELKDVINGALGIKDKAFGYNPSFLYPANDGIRVLPESFLSGIDQVERDCELIEVDTKRRRALFHDRRRGESRTEHYESLVSTIPVPELVRRCPDFPQRLKEAAAGLRWVSVYNVNLGVSREQVSDKHWIYFPESGYPFYRVGFPMSFSPSLGRSGCSSMYVEISHRPAEQRAPEQLIEQARSGLEQAGILRPDDDLVVADVKDLRYAYVYFDRHRAKAIPAILAELERRGIHSIGRYGRWEHTSMEDAIGQGKRLAEQLRGQQAQPVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0N0</accession>
    <name>A0A1W1I0N0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Asparagine synthetase</fullName>
            <ecNumber evidence="8">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_0241</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46413">
        <property type="protein sequence ID" value="SLM46413"/>
        <property type="gene ID" value="NSJP_0241"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0241"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="7">
        <location>
            <begin position="2"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="658" mass="74092" checksum="ADE6A299D2E4876D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0N3</accession>
    <name>A0A1W1I0N3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46551">
        <property type="protein sequence ID" value="SLM46551"/>
        <property type="gene ID" value="NSJP_0379"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0379"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="54" mass="6357" checksum="A7A0947861D14392" modified="2017-06-07" version="1">MMNIFEDGWSVWWTRLIAVFFILLVAWFLLRDWFSAPLQPYVPPPSSMPTTPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0P9</accession>
    <name>A0A1W1I0P9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 3-oxoadipate enol-lactonase</fullName>
            <ecNumber evidence="2">3.1.1.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.24" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0404"/>
    <dbReference type="EnsemblBacteria" id="SLM46576">
        <property type="protein sequence ID" value="SLM46576"/>
        <property type="gene ID" value="NSJP_0404"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0404"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047570">
        <property type="term" value="F:3-oxoadipate enol-lactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="266" mass="28771" checksum="9DC22CA29332F1C7" modified="2017-06-07" version="1">MIHQANGIRLGYTDRGAGLPLVFLHAFPLNRTMWTDQEALSSRFRIITVDLRGHGESDAPAWRYSLEQYAADVRQLLGLLGVSRAVFVGLSMGGYLEFALYRNCPDLIRGLVFADTRAEADGPEQVKWRFDLAQRTAAVGPSAVIDDMLPKLLSPGAYQRRPDLVERVKSIQAAAPVHGIVGDLMAMAERPDSTALLGSIAVPTLVIVGQEDVLTPPADAERIAHGIPGARLVTIPDAGHLSNMEQPDQFNRALAEFAAGLPAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0V5</accession>
    <name>A0A1W1I0V5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46621">
        <property type="protein sequence ID" value="SLM46621"/>
        <property type="gene ID" value="NSJP_0449"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0449"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021302">
        <property type="entry name" value="DUF2780_VcgC/VcgE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11075">
        <property type="entry name" value="DUF2780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013207071" evidence="1">
        <location>
            <begin position="23"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="143" mass="14987" checksum="EA959D40C6A92C0F" modified="2017-06-07" version="1">MHRSIILTGFLVCAFLSVSGCAGMDTKGMTDPLVKILTSQLDVTANQAKGGLGSTLTMAKEKLPPPDFESLTKYVPGTEGYMKAAKDLGAVTGPISDPTALQAAYSKLGMSWDKVGKFSKVLSDFVGTSGGEQAQSFLTSLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Z2</accession>
    <name>A0A1W1I0Z2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46665">
        <property type="protein sequence ID" value="SLM46665"/>
        <property type="gene ID" value="NSJP_0493"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0493"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="139" mass="15313" checksum="843E3667E56F5F6E" modified="2017-06-07" version="1">MATAVRRPAQPHHYTSAVQTFHSSGRLDKFTDILLELRARHRESPYSGSWLSTRLSGSAEANHAPFTGSVLCGARPGRSYGNGTACCADRRRRARVGGRHLSVGDEPLGYGERIGSGRHRWNSKRVSFRTAMAQVVNVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I106</accession>
    <name>A0A1W1I106_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46549">
        <property type="protein sequence ID" value="SLM46549"/>
        <property type="gene ID" value="NSJP_0377"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0377"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007251">
        <property type="entry name" value="Iron_permease_Fet4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04120">
        <property type="entry name" value="Iron_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="146" mass="16524" checksum="1226942522A95AED" modified="2017-06-07" version="1">MTYRRGGHHAGMSGMFSRFAKHCAVIMGHPWAFGGALAVIVCWAVAGPAFRFSDTWQLVINTGTTIITFLMVFLIQNTQNRDSSAIQIKLDELIRSTRGAHNALLDLEELTQRDLDRFLKRYQSLAQSARRQVRDGWKDVDTPEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I172</accession>
    <name>A0A1W1I172_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Transcription factor IscR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0570"/>
    <dbReference type="EnsemblBacteria" id="SLM46742">
        <property type="protein sequence ID" value="SLM46742"/>
        <property type="gene ID" value="NSJP_0570"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0570"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="156" mass="16996" checksum="08070A2BF70016E4" modified="2017-06-07" version="1">MLKISKKADYALMALQHIASVQFGDLTPGRVVNTKEIAEEYHIPLELLAKVLQTLAKNGMIESHNGPKGGYVLGRNASQITIAQILESIEGPLGITDCSHEKDGDVCLQREHCNIRTPLLKVQDSIYQLLNSMTLQDMLGGTPLITIQSSTAQGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1A8</accession>
    <name>A0A1W1I1A8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46623">
        <property type="protein sequence ID" value="SLM46623"/>
        <property type="gene ID" value="NSJP_0451"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0451"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010725253" evidence="2">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="130" mass="12876" checksum="1116397C2629DA2B" modified="2017-06-07" version="1">MSRMTNRVFLLTLTVLLLGLPAVGDTQSTSPSLNGTQSVVPLSQQPTAFDTTTTAGAAGGVTPAQVAPGVNTAVSSSIGKSFGTVGRGLPGFPGGPPLNGTPGVGDTSTSSMRPKTIPPLLCDPAVDIPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1I9</accession>
    <name>A0A1W1I1I9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5 7" type="primary">purK</name>
        <name evidence="7" type="ORF">NSJP_0521</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0521"/>
    <dbReference type="EnsemblBacteria" id="SLM46693">
        <property type="protein sequence ID" value="SLM46693"/>
        <property type="gene ID" value="NSJP_0521"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0521"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="108"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="149"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="184"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="269"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="385" mass="42042" checksum="6FADFE6D7F6DA3A7" modified="2017-06-07" version="1">MIAAGAVLGVLGGGQLGAMFAEAAHRLGYGVAVWDPDADAPAHRIVRHSFTQSFADPHAFDSFTRLASVVTYEWENVPWMLCRDIEQRKPLRPSSAILKLIQDRIVQKDCLRAHGFPVPRFAVVSSPEHLSEAVAEIGCPAVCKTATAGYDGKGQWRIRDESDLVEVREAFRATGRQDLRWIVEPLVPFERELSVLAVRGIDGEMVVYPIAENEHDEGILRKTIVPARISPSLAAQIGELARQTVSRLDGIGVFCLELFELSGGQILINEIAPRPHNSGHYTLDACSVSQFEQQVRSICGLPLGKVGLTTPAVMVNLIGDDATRVTQGDCAALLAGPGSVLHLYGKRTVRPRRKMGHVTFVASRQETALERAFHLQDCLSKTAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1R8</accession>
    <name>A0A1W1I1R8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PAPS_reduct domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0601"/>
    <dbReference type="EnsemblBacteria" id="SLM46773">
        <property type="protein sequence ID" value="SLM46773"/>
        <property type="gene ID" value="NSJP_0601"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0601"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="1">
        <location>
            <begin position="19"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="255" mass="28634" checksum="F140CDB48A993575" modified="2017-06-07" version="1">MKPLHESVNQIPESAVIGLAFSGGKDSMACLHLLRDRLSFAIFVDTGFTLPETLECVTYARALVPMHVVRTDRKGQNAREGIPADVVPIDYTSFGQQFTGRKPVTIQSYRQCHFENVNKPLWDKAISLSVTHLVSGSRADEHKNAMTQAVMPFEEMTQLCPIHDWSEQDVLDYLETVMEVPAHYYAVPQSSSLDCFDCTAFVQETTEFIPWLREHYPERYAQYAIRNNALYSAIQDALGLPVPEPPAAPIVESLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1U3</accession>
    <name>A0A1W1I1U3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0806"/>
    <dbReference type="EnsemblBacteria" id="SLM46978">
        <property type="protein sequence ID" value="SLM46978"/>
        <property type="gene ID" value="NSJP_0806"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0806"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="545" mass="60919" checksum="D335219F62D81674" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1V7</accession>
    <name>A0A1W1I1V7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-amino-3-ketobutyrate coenzyme A ligase</fullName>
            <shortName evidence="1">AKB ligase</shortName>
            <ecNumber evidence="1">2.3.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">kbl</name>
        <name evidence="3" type="ORF">NSJP_0824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + glycine = (2S)-2-amino-3-oxobutanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:20736"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="2.3.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="1">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.29" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0824"/>
    <dbReference type="EnsemblBacteria" id="SLM46996">
        <property type="protein sequence ID" value="SLM46996"/>
        <property type="gene ID" value="NSJP_0824"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0824"/>
    <dbReference type="UniPathway" id="UPA00046">
        <property type="reaction ID" value="UER00506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008890">
        <property type="term" value="F:glycine C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019518">
        <property type="term" value="P:L-threonine catabolic process to glycine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00985">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011282">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01822">
        <property type="entry name" value="2am3keto_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="44"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="111"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="208"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="239"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding; shared with dimeric partner" evidence="1">
        <location>
            <begin position="272"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="396" mass="42326" checksum="98854E2ADAFA7BDC" modified="2017-06-07" version="1">MAYSSFKDALDRALAEIRSRGTHKSERLLLSPQGSEILVAQGLVLNLCANNYLGLANHPQIIEAAMDGLRTHGYGLASVRFICGTQDLHKRLERAVSAFLGTDDTILYGSCFDANGGLFEVLLDERDAVISDALNHASLIDGIRLCKAKRLRYAHSDMEELESRLAEAQGCRTRLVATDGVFSMDGDLAKLDRIVDLAERYDAAVIVDDSHATGVVGRQGKGTPDHFGVADRIEIVTGTLGKALGGAAGGFTSGKAEIVELLRQRSRPYLFSNTLPPAVASGALRALELVAAGDDLRAALRRNAAFFRAKLSTLGFRLVPGDHPIIPVMVGDAALAAALAEGLLAEGVYVVGFSYPVVPEGQARIRVQMSAAHTLEQLETAVHAFANVGRQLRVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Z1</accession>
    <name>A0A1W1I1Z1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47030">
        <property type="protein sequence ID" value="SLM47030"/>
        <property type="gene ID" value="NSJP_0858"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0858"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="88" mass="9620" checksum="13EB790DD19E019A" modified="2017-06-07" version="1">MPGQRSEYRTQLSSAHDKTASIAYGVKAVGLLLAVGSGLIVCLFCYLAGLWHGGMLGSGKYLREVLSKRETLEECVMIRTVNKKTWNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Z6</accession>
    <name>A0A1W1I1Z6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Phage integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0864</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47036">
        <property type="protein sequence ID" value="SLM47036"/>
        <property type="gene ID" value="NSJP_0864"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0864"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="118" mass="13082" checksum="2E6FF901A8785863" modified="2017-06-07" version="1">MRQVRFHDLRHTFASLLLQNGESPVYVKDQMGHSSIQVTVDLYGHLIPGGNQQAVDPLDTPMEYATCKPESATSAQPAQTNHGPVSSDRMRNPAVRRGAYGVDDGFRTRDLRIHNPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I205</accession>
    <name>A0A1W1I205_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized endonuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47027">
        <property type="protein sequence ID" value="SLM47027"/>
        <property type="gene ID" value="NSJP_0855"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0855"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="42" mass="4941" checksum="1044DA710BBD8434" modified="2017-06-07" version="1">MDKYGRIIANVLLPDGSNVNNELVKDSWCWWYRKFAPKDLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I214</accession>
    <name>A0A1W1I214_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_0860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0860"/>
    <dbReference type="EnsemblBacteria" id="SLM47032">
        <property type="protein sequence ID" value="SLM47032"/>
        <property type="gene ID" value="NSJP_0860"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0860"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="15"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="81"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="132"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="253"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="326"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="633"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="756" mass="83141" checksum="8525B1A356C554CB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I216</accession>
    <name>A0A1W1I216_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative RNA polymerase sigma-E factor (Sigma-24)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0876</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47048">
        <property type="protein sequence ID" value="SLM47048"/>
        <property type="gene ID" value="NSJP_0876"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0876"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="129"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="210" mass="24175" checksum="66E028938894438C" modified="2017-06-07" version="1">MRRTPPSQSPRPPQQPNDFDKLYRDHVDLVYRYAHRLCGETETAKDLVQETFLNAYRGFEGFRGDARISTWLYTIASRACMRMRRKRRGQPERELSLDEFIPTSDGEFRLQIPVDGLTPEEALENKELRQALDQAIQKLPSKYRVTLVLRDMEGLSAKEVGTVMGVNERAVKSRLHRARLFVRRELSARGITEPGRDSVGAPRQPEGFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I231</accession>
    <name>A0A1W1I231_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47070">
        <property type="protein sequence ID" value="SLM47070"/>
        <property type="gene ID" value="NSJP_0898"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0898"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="75" mass="8499" checksum="BC8EC14E925904BF" modified="2017-06-07" version="1">MLKRDAANTFPHVRHTGLKAFCTAAQTEQRTDEAVDDFTSSPYEGPPDRASNCPIYPAAVRPTFFNERKRESARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I261</accession>
    <name>A0A1W1I261_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47087">
        <property type="protein sequence ID" value="SLM47087"/>
        <property type="gene ID" value="NSJP_0915"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0915"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="34" mass="3710" checksum="2DF16D9DC980EF08" modified="2017-06-07" version="1">MDKIGTWLAITGVAIGFVVLGWLLFSDNSSNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I279</accession>
    <name>A0A1W1I279_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminotransferase, PLP-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yfdZ</name>
        <name evidence="2" type="ORF">NSJP_0751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0751"/>
    <dbReference type="EnsemblBacteria" id="SLM46923">
        <property type="protein sequence ID" value="SLM46923"/>
        <property type="gene ID" value="NSJP_0751"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0751"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="398" mass="44893" checksum="7A5B7F51CB8C4F9F" modified="2017-06-07" version="1">MGLADHFYRLKRLPPYVFAQVQSLKLDARHRGEDIIDFGMGNPDQPTPPHIVDKMIEAARKGRNHRYSASRGITKLRHAIAGWYRRNYDVDLDPETEAIVTIGSKEGLAHLSLAMIGPGDVVLTPTPTYPIHMYSFIIAGGEVRGIELRPDSDFFDDLQRVYRQTFPRPRILVINFPHNPTTAVADLEFFKKIVAFAKEHNVIVIHDLAYADLVFDGYKAPSFLQVQGAKDVGVEFYTLSKAYNMPGWRVGFCVGNREVVGALAKIKSYLDYGIFQPLQIASVIALNGPQDCVKETVLRYQKRRDVLVSGLNRIGWNVAKPRATMFVWARIPLPYRHMGSLEFSKLLLREAKVAVSPGIGFGEGGDEYIRFALVENEHRTRQAVRGIRKALKLEGTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I285</accession>
    <name>A0A1W1I285_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47126">
        <property type="protein sequence ID" value="SLM47126"/>
        <property type="gene ID" value="NSJP_0954"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0954"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011963826" evidence="1">
        <location>
            <begin position="23"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="141" mass="15766" checksum="C7EE1B8B63ADA6EC" modified="2017-06-07" version="1">MIFPYRVPRVLPLLVSALLAAACGGPWRDGYFNKGVNRLTQDEVTEKLGPPHTAKTPALGGDSIWTYRVPITERELSSLHFSGLSNATKQATSLLGKAGEGPKEILYCYRYTLTFNEQKVLKQWKREECVPGTREALLQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I290</accession>
    <name>A0A1W1I290_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NfeD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0919"/>
    <dbReference type="EnsemblBacteria" id="SLM47091">
        <property type="protein sequence ID" value="SLM47091"/>
        <property type="gene ID" value="NSJP_0919"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0919"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="54"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="144" mass="15495" checksum="4B4743DC0F85353E" modified="2017-06-07" version="1">MVWWYWMVLGLALLGAEMATPGGFYILFFGLAALIVGTLAGTEVVQTDWLQWLLFSVVAVGSLLIFRGPLLAKLSPHGHAQPDIDSIVGETAIPLEPLAAGEIGKAELRGTTWTAKNVGAEPLKKGQRGKVARIEGLTLWITNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I293</accession>
    <name>A0A1W1I293_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Succinate dehydrogenase and fumarate reductase iron-sulfur protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0942"/>
    <dbReference type="EnsemblBacteria" id="SLM47114">
        <property type="protein sequence ID" value="SLM47114"/>
        <property type="gene ID" value="NSJP_0942"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0942"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="263" mass="28512" checksum="AFAF9DC429AFF6A0" modified="2017-06-07" version="1">MHFTLSVWRQRGPDGQGAFVSYPADDISPAMSFLEMLDVVNQRLILKGEEPIAFESDCREGICGACSLVINGIPHGPDRGVATCQLYMRRFIDETVITIEPWRARAFPVIRDLVVDRRALDRIMQAGGYISSNTGGAVDGNTFLIGKDRAETAMDAASCIGCGACVAACRNASAMLFVAAKVSHLAHIPQGGPERARRADAMMKAMDREGFGSCGNQYECEAVCPKSISVHFIATFNREFLRSTIAEPGPLTDAPADPHAEFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2I2</accession>
    <name>A0A1W1I2I2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative 6-phosphofructokinase (Modular protein)</fullName>
            <ecNumber evidence="9">2.7.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_0907</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0907"/>
    <dbReference type="EnsemblBacteria" id="SLM47079">
        <property type="protein sequence ID" value="SLM47079"/>
        <property type="gene ID" value="NSJP_0907"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0907"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="8">
        <location>
            <begin position="428"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="772" mass="84641" checksum="1D0B5BB496CF7B9D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Q6</accession>
    <name>A0A1W1I2Q6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47296">
        <property type="protein sequence ID" value="SLM47296"/>
        <property type="gene ID" value="NSJP_1124"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1124"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="182" mass="20589" checksum="7AAADC15FFF4C537" modified="2017-06-07" version="1">MLRMHGQHDNLEVRLVLLELCRRVKTVQQGQGNIDDDNVRLQLRRLCNERATVCDDADQLKLRLEQFLNALCDQHMIVRQENAIGFRHDHLASTVWSRVEGMKEVYPDFRTRLKGPVKALAKHRQMALGRPKGDAGVNPGIFLGGNRTAQATVGSHLKGQTVPFGLHHGQSVPRSHPIREDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2S1</accession>
    <name>A0A1W1I2S1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4149 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1099</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1099"/>
    <dbReference type="EnsemblBacteria" id="SLM47271">
        <property type="protein sequence ID" value="SLM47271"/>
        <property type="gene ID" value="NSJP_1099"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1099"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="DUF4149"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4149" evidence="5">
        <location>
            <begin position="14"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="162" mass="17606" checksum="E770723F3EB977C4" modified="2017-06-07" version="1">MSIAWLPLISLHILAAVLWIGGMLFLSLILAPLLRQTHDPSSFRLLFSAAARRFRSMVRLAIVILLGTGPLLLEIRGLSIMDPSTWPSVLLVKLTLVGLLLLFTLLHDLVLGPRVLRIGSQPVATRTAQDLFLLSVSRVVPRLALLIALAVLVAAAILARSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2U0</accession>
    <name>A0A1W1I2U0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetoacetate metabolism regulatory protein AtoC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">atoC</name>
        <name evidence="8" type="ORF">NSJP_1142</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1142"/>
    <dbReference type="EnsemblBacteria" id="SLM47314">
        <property type="protein sequence ID" value="SLM47314"/>
        <property type="gene ID" value="NSJP_1142"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1142"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="145"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="451" mass="50022" checksum="439B5CF30CE22153" modified="2017-06-07" version="1">MDVHSHVLVVDDDEDTRGLLSEILAKEGYDVETASDGKTALERITDRPPDLVMSDIHMPSLDGMSLLEELRSRNQDVPVILMTAFGSLKTAVDGLRSGAFDYLSKPFIVDDIRLVVRRALEHKHLSRQNQALKEQLRDRYRFDNLVGSSAGIVSVYKSIARVAHTDSTVLLQGESGTGKELIARAVHANSARSAGPFVAVDGGSLAETLLESELFGHERGSFTGAVASKKGLLEKAHQGTCFLDEVADLSPVLQGKLLRVIQEREIRRVGSNAPMNIDVRIIAASKKDLDQLVKAGTFREDLYYRLNVVTIQIPPLRERAEDIPLLTQYFIQMYGQKKSPPVTGIAPEAMSLLTRYWWPGNIRELEHAIERAIALTPQSVIFPEDLPQSIQTATVQAAAQARGWVTLAELEKDHILRVLEAHNQDLGRAAAILGIHRKTLLRKLRYFGYPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Y0</accession>
    <name>A0A1W1I2Y0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycogen debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1180"/>
    <dbReference type="EnsemblBacteria" id="SLM47352">
        <property type="protein sequence ID" value="SLM47352"/>
        <property type="gene ID" value="NSJP_1180"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1180"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006451">
        <property type="entry name" value="Glycogen_debranch_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024742">
        <property type="entry name" value="Glycogen_debranch_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="PTHR10569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12439">
        <property type="entry name" value="GDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01561">
        <property type="entry name" value="gde_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_N" evidence="2">
        <location>
            <begin position="24"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="GDE_C" evidence="1">
        <location>
            <begin position="292"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="673" mass="75897" checksum="A7DE391C85C3FF77" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Z5</accession>
    <name>A0A1W1I2Z5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoesterase, ICC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1169"/>
    <dbReference type="EnsemblBacteria" id="SLM47341">
        <property type="protein sequence ID" value="SLM47341"/>
        <property type="gene ID" value="NSJP_1169"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1169"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016538">
        <property type="entry name" value="UCP008292"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008292">
        <property type="entry name" value="UCP008292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="9"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="265" mass="28917" checksum="AE718A941F2600F5" modified="2017-06-07" version="1">MGAQHGTVRIAAVGDLHCPRTSEEELRGLFHRLPEEADILLLCGDLTEFGRVEEARRLGEHLAALRPLPILAVLGNHEFESGQQEEVSRVLTDQGVTILDGTAVEVHGIGFAGVKGFCGGFGERALQPWGESILKHFVRESVDETLKLESALAKLRAPSRVVVTHYAPVAETVRGEPPEIFPFLGSSRLEEPVNRYGASVLFHGHAHHGSLEGRTMGGVPVYNVAFPLLRRHFPDGRAVRILTLPVSSETPNAGREDFHAVQRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I389</accession>
    <name>A0A1W1I389_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47435">
        <property type="protein sequence ID" value="SLM47435"/>
        <property type="gene ID" value="NSJP_1263"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1263"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010767">
        <property type="entry name" value="Phage_CGC-2007_Cje0229"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07087">
        <property type="entry name" value="DUF1353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="222" mass="26253" checksum="D1453305D3D851B5" modified="2017-06-07" version="1">MSRQPHSQCLERRTLFRVSAGLLLLFPYMLMRYLPLLSVGIVRAEELTEDREITKEIWLNEFFQIKPPIGALHLFRFADEMYATTKPISWVPAKGEQQKTYEQVDVPIGFVTDFASVPRIFWQFLPRDGKYTYPAIVHDYLYWTQNRSREMADQILRIGMQEFGIDPIVVNAVYWSVRAAGDIAWKHNAKLKSQGERRILKRFPEDPLMKWQNWKEHNDVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3D0</accession>
    <name>A0A1W1I3D0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Leu/Ile/Val-binding protein, periplasmic-binding component of ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1336"/>
    <dbReference type="EnsemblBacteria" id="SLM47508">
        <property type="protein sequence ID" value="SLM47508"/>
        <property type="gene ID" value="NSJP_1336"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1336"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="1">
        <location>
            <begin position="44"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="414" mass="44487" checksum="8A8E0A9EB6A1EDDC" modified="2017-06-07" version="1">MANVSRRGFLQLSALTSFTIISGEWAVRTSDHSRCSGTAWAAEPIKIGILDPLSSPYKTSSIHDVHGANVAVDLFNKNGGVIGRPVMLLEADDASNADTAVKAATKFIREDQVDFLMGTFNGDCALAVSALAHREHKLFMVTGACLPELTGEACNPHTFVFMPHARMLAEAVVPEVIKAYGAKWFMITANTLDGKIAAQAVVDAAKPRNVQFVGETVLPFGTSDYTAALTTARSKNPTAIILNLYGWDLVNALKDYGKLDLAKEKIGLGGLISGEQIGRPLGYANNAGIWGLIWDPKIKTESSRRFIQAVVDKYNHTPTSRCYLGYAAMTQILEAVHRAGSTETAAVIKALEGHQFDGLKEGQSVFRASDHQHVQDVLVGEAYGRELGLGHFKILTTLQGDANPGAADRGNCAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3D5</accession>
    <name>A0A1W1I3D5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein NSJP_1344</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybaB</name>
        <name evidence="3" type="ORF">NSJP_1344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1344"/>
    <dbReference type="EnsemblBacteria" id="SLM47516">
        <property type="protein sequence ID" value="SLM47516"/>
        <property type="gene ID" value="NSJP_1344"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1344"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="107" mass="11166" checksum="B644F9DEAC9A33FE" modified="2017-06-07" version="1">MKNPFGNMANIMKQAQAMQQQMAKVQEEAANKTATGSAGGGTVTVTANGAMQLVGVSINPEAVKADDVEMLQDLILAASNEALRKAHDMMAEEMKAVTGGMNMPGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3G2</accession>
    <name>A0A1W1I3G2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47557">
        <property type="protein sequence ID" value="SLM47557"/>
        <property type="gene ID" value="NSJP_1385"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1385"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="58" mass="6370" checksum="459EC4F8AC83D6C0" modified="2017-06-07" version="1">MASSPRYSRVLYRSFVSPSRGVMRIDLHRPTEQTGPAGTCLTAYAALSRIRLSSTTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3H7</accession>
    <name>A0A1W1I3H7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1267"/>
    <dbReference type="EnsemblBacteria" id="SLM47439">
        <property type="protein sequence ID" value="SLM47439"/>
        <property type="gene ID" value="NSJP_1267"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1267"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="105" mass="11702" checksum="C9BD2E00B86A6F64" modified="2017-06-07" version="1">MADTTVRHFLPWVRHGTANAITTIDSLSRNQPAQVSISAKITLNALDLPPTELRLYGPGDVTALDPSQIVRMEPRPHTTTFESNLFPHIEFDRPAPSQISWSVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3M3</accession>
    <name>A0A1W1I3M3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta_helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1434"/>
    <dbReference type="EnsemblBacteria" id="SLM47606">
        <property type="protein sequence ID" value="SLM47606"/>
        <property type="gene ID" value="NSJP_1434"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1434"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="120"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="270" mass="29517" checksum="8120C142CA8BBDFD" modified="2017-06-07" version="1">MSTEQDHRDRQDIPPNPLGGRTLVVDARDAKAYPRPSDALAEADALDQVFVRPGTYEDKIFVASRPIALIGAGRDLVQVFSRRGAPLYLQQVPSGRISGISFRYVGSDQHSAMNLLDSTCTVTQCRAMEGILSGVVIYGPESRPTFVGNEFCGNRESGLFVFAGAQPRLAENVSRGNHHFGIAVRDDGSYPELVRNQCRENMMSGILLFHHAKALLMDNRCTDNSHWGFVMTPDCIPSPDQDALESSNTLTPNPRGAVSVTETPLSEIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3V0</accession>
    <name>A0A1W1I3V0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Shikimate kinase</fullName>
            <shortName evidence="2">SK</shortName>
            <ecNumber evidence="2">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">aroK</name>
        <name evidence="3" type="ORF">NSJP_1502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shikimate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1502"/>
    <dbReference type="EnsemblBacteria" id="SLM47674">
        <property type="protein sequence ID" value="SLM47674"/>
        <property type="gene ID" value="NSJP_1502"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1502"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="166" mass="18261" checksum="0FD39BF8D4F9AB00" modified="2017-06-07" version="1">MNIVLIGYRGVGKSSVGKILASQLKRELISTDAEVIRRAGQTIPAIVEQHGWEYFRERESDVCRDLSVRDNLIIDTGGGAILRPHNVDALKANGKLFWLTASVESIAARIGGDTQRPSLTGTKSFVEEIEEVLRERTPKYRAAADCIVTTDGQLIEQVVEQIIGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I401</accession>
    <name>A0A1W1I401_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1558"/>
    <dbReference type="EnsemblBacteria" id="SLM47730">
        <property type="protein sequence ID" value="SLM47730"/>
        <property type="gene ID" value="NSJP_1558"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1558"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037079">
        <property type="entry name" value="AF2212/PG0164-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015018">
        <property type="entry name" value="DUF1905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08922">
        <property type="entry name" value="DUF1905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="186" mass="20266" checksum="E8DDB1C4B902EAC8" modified="2017-06-07" version="1">MSQVAKRSRFKATLLRPAKSGKASSWAFLVLPKSASEKLPRRGRTSVEGTINGHLFHATLEPDGQLSHWLKVSKALREASGVEIGETVTLKIAPMAKEPEPKLPPDFQAALAASPKAKAIWDATTTIARIDWVHWVESAKQAKTRKSRIDDACDMLASGKKRVCCFDPSGFYSKSFSAPTPHRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I427</accession>
    <name>A0A1W1I427_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47754">
        <property type="protein sequence ID" value="SLM47754"/>
        <property type="gene ID" value="NSJP_1582"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1582"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="13"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="126" mass="14226" checksum="0D6A9B01FE7F7832" modified="2017-06-07" version="1">MTFSDRSLDRIIERRKHRRSMLPPGSLLSFSPVSASLDGAFDVEGEGVLLDLSQGGCRVSSETSVMLEQPYTLIIQLPDFRRPVTVESAIARWKGTHTFGVMFIAMHQEQEQSLNEFLRYLHSNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4I3</accession>
    <name>A0A1W1I4I3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfopyruvate decarboxylase, alpha subunit</fullName>
            <ecNumber evidence="2">4.1.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">comD</name>
        <name evidence="2" type="ORF">NSJP_1713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.79" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1713"/>
    <dbReference type="EnsemblBacteria" id="SLM47885">
        <property type="protein sequence ID" value="SLM47885"/>
        <property type="gene ID" value="NSJP_1713"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1713"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050545">
        <property type="term" value="F:sulfopyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="165" mass="18058" checksum="23570AEEF2DCFF24" modified="2017-06-07" version="1">MIDSDAFVRAMQDMGVDFFTGVPDSLLGGIIAELIDRHLYTPAVREDEAVAMAAGAYMAGKIPAVLMQNSGLGTSLNTLISLNVIYRQPCILIVSWRGQGGKDAPEHLVMGEVMPQFLDTMKIPHRTLTEKTAVEDFKWVAETFMKQRIPVALFIGKGVVKGLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4K1</accession>
    <name>A0A1W1I4K1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpmF</name>
        <name evidence="6" type="ORF">NSJP_1766</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1766"/>
    <dbReference type="EnsemblBacteria" id="SLM47938">
        <property type="protein sequence ID" value="SLM47938"/>
        <property type="gene ID" value="NSJP_1766"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1766"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044957">
        <property type="entry name" value="Ribosomal_L32p_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35534">
        <property type="entry name" value="PTHR35534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="61" mass="7053" checksum="11E7D8A4976C4551" modified="2017-06-07" version="1">MPNPKHKHSRARRDKRRTQKLRVTPPGMSVCPQCHELKLPHYTCLNCGTYKGKAVIQVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4L6</accession>
    <name>A0A1W1I4L6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47881">
        <property type="protein sequence ID" value="SLM47881"/>
        <property type="gene ID" value="NSJP_1709"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1709"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="21"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="138" mass="15318" checksum="BEC5348D76338B00" modified="2017-06-07" version="1">MKQRVVDLGIDVKEAYTPLDRRYAERASLRIPVLYASADGSSLLKAEGLLTDLSKSGCNIEGTVSPPVGSRITLFLYLADGQPPLCLTDVTIPRVKGLAFAAEFPDLMPEERKRIQQLIWRHVTFSASRQTRAGFRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4P9</accession>
    <name>A0A1W1I4P9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47859">
        <property type="protein sequence ID" value="SLM47859"/>
        <property type="gene ID" value="NSJP_1687"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1687"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="91" mass="9543" checksum="78F357E2875F1908" modified="2017-06-07" version="1">MVHDQHPSTAVFSPAGVAVGLGTVLIPSRVSAGNDFSRFAAKGHPLRYPTQRGGRACPVNQPRASRVSPSQIHPSLHMAGTMRCLPSTPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4V0</accession>
    <name>A0A1W1I4V0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_1850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48022">
        <property type="protein sequence ID" value="SLM48022"/>
        <property type="gene ID" value="NSJP_1850"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1850"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="156"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="268" mass="28804" checksum="EC055FE2C340BA7B" modified="2017-06-07" version="1">MGNVIKKLVVGLVVAGALFGITMALDFPSIFQMTFAAYALLGTAVFILLDAPTLKPMYGVKALVALVGFYVVLCVVYIAGASLWPQYDPEDEKGKIEKILKPKRAATEQGKADELLVRVKALDEQAKALSARIKALGGDQAATSQSAGGPGAPPATTGAAGGDVLKVGEDQWQLQECYNCHKLKGEGGKKRGPELDNIGSLLTVDEIKQKILDPKSWMADGFEKEYEKGKMPDKYKDLMEEKDVVALATWLGTFKNTSVGTPKPIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I508</accession>
    <name>A0A1W1I508_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter, ATPase component, ATP-dependent toluene efflux transporter</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yrbF</name>
        <name evidence="5" type="ORF">NSJP_1839</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1839"/>
    <dbReference type="EnsemblBacteria" id="SLM48011">
        <property type="protein sequence ID" value="SLM48011"/>
        <property type="gene ID" value="NSJP_1839"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1839"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="251" mass="27615" checksum="0188E6BD33478504" modified="2017-06-07" version="1">MIRLVGVEKTLGGQRVLQGLDLSIPAGQLTTVIGRSGEGKSVLLKHMIGLMQPDRGEVWVGDVEISHLKGKRLNDVRKRFAMLFQGAALFDSLSVFENVAFPLREKLQMKGSEVSRRVEEKLDQVGLKGMGHKYPAELSGGMKKRAGLARALVMEPEIILFDEPTTGLDPLMAKSIHDLIVSMQRRFQFTAVMVSHEIPEVFGISDWVAMLRRGKIAAMAPAKEFVRIDDPEIQEFITAGGTLALPKALVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5J0</accession>
    <name>A0A1W1I5J0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytidine deaminase protein</fullName>
            <ecNumber evidence="4">3.5.4.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.4.5" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2073"/>
    <dbReference type="EnsemblBacteria" id="SLM48245">
        <property type="protein sequence ID" value="SLM48245"/>
        <property type="gene ID" value="NSJP_2073"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2073"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="135" mass="14605" checksum="A5DC49E7E73DFD6F" modified="2017-06-07" version="1">MSHLISSFAMTDDDLIQAATQLVGEFRTGPDCVAGRVAAALVTAKGNVYTGICIDLVCSLGSCAEYSAIAEMLKARESEIHTIVSVCGSRIVPPCGRCRELMRQVSDANARTRIIVARGRMATLSELLPFEWKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5J9</accession>
    <name>A0A1W1I5J9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48211">
        <property type="protein sequence ID" value="SLM48211"/>
        <property type="gene ID" value="NSJP_2039"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2039"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="172" mass="19774" checksum="C55B681BC5070FDD" modified="2017-06-07" version="1">MRNFNTRFRLRDSDKQIRLLYTLFLFLILAGFTFSFLWAHSMTGLSPQGIADHYRGSDSTFGEPMSFRELAEVTHFHLFTMPVVFIILAHVLYLTATTSAIKIGTTWMAFGGVMLDLLSPWLISYVSPLFFLTMLMGDVFMTVGFLIMMAIPLYEMWVLEQPLMSGKTNEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Y4</accession>
    <name>A0A1W1I5Y4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48416">
        <property type="protein sequence ID" value="SLM48416"/>
        <property type="gene ID" value="NSJP_2244"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2244"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="132" mass="14858" checksum="D8C7BCD29440A7F7" modified="2017-06-07" version="1">MEIDWPEGPPTEVDLPAGTYVASYKGYAHRNMFRQSKIQLNFKIVAPSESAGIEVSLFATFPLQGKPPHRSKYFELWSKANGRPPIRGQRMSAGIFEGYWNVRIEWSKPRNGGPGMPIIVELISREAGGPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Z1</accession>
    <name>A0A1W1I5Z1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48395">
        <property type="protein sequence ID" value="SLM48395"/>
        <property type="gene ID" value="NSJP_2223"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2223"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="79" mass="8812" checksum="CF50345F77CF9E3C" modified="2017-06-07" version="1">MDSTSVYYKDFRIESCPSQHAGTEQWKARIFISWAPHDAKTTRSFSSQDAYQTSEEATLQGLALGELIIDGKIPGLSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I628</accession>
    <name>A0A1W1I628_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2157"/>
    <dbReference type="EnsemblBacteria" id="SLM48329">
        <property type="protein sequence ID" value="SLM48329"/>
        <property type="gene ID" value="NSJP_2157"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2157"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="221" mass="24432" checksum="3B92C5246B368FCE" modified="2017-06-07" version="1">MSQTSATEDRFISQLIHDKPLLHLVSQRDAEEYGFLGLRAGPVNWAVDADVLRYLSKIVKPHHRSLETGCGHTTVAFAALGARHICVNPKPDECRRIQEYLTSIGAPTDRLNFVVDSSDTGLASLDPDLKVDVGFIDGCHGFPFPALDWHYIDQHLEIGGILGVDDTNISSVKVLTRFLETNGTYASEDVVGKTNTDASLSTSENYRDRLRVFLGRDVGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I676</accession>
    <name>A0A1W1I676_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rplW</name>
        <name evidence="6" type="ORF">NSJP_2340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2340"/>
    <dbReference type="EnsemblBacteria" id="SLM48512">
        <property type="protein sequence ID" value="SLM48512"/>
        <property type="gene ID" value="NSJP_2340"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2340"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="97" mass="11198" checksum="179BF7C6D82A7720" modified="2017-06-07" version="1">MKLDLHRVLIQPLLTEKVTAMRESNNTVSFLVHPEANRLQIKQAVETLLKVKVERVNVLNVQGKIKRLGRFSGKRSDWKKAFVKLKDGEKLELYESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6D4</accession>
    <name>A0A1W1I6D4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rpsK</name>
        <name evidence="9" type="ORF">NSJP_2363</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2363"/>
    <dbReference type="EnsemblBacteria" id="SLM48535">
        <property type="protein sequence ID" value="SLM48535"/>
        <property type="gene ID" value="NSJP_2363"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2363"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="127" mass="13686" checksum="C02B72D6483D4AC1" modified="2017-06-07" version="1">MSVKKGKKKERRIVQSGIAHVQASFNNTIVTITDMSGNTVVWASAGNQGFKGSRKSTPFAAQRAGEAAARKAMESGMRQVDVYVNGPGSGRESAIRSLQGAGLRINLIRDVTPIPHNGCRPPKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6J6</accession>
    <name>A0A1W1I6J6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48463">
        <property type="protein sequence ID" value="SLM48463"/>
        <property type="gene ID" value="NSJP_2291"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2291"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="103" mass="11778" checksum="977D38ACC17B60B2" modified="2017-06-07" version="1">MPFTIRPFLRTPLCCPVTYQVEDFEGFGMVWNVTPMGWRFSGNLPLRVGEVCSLTVLLPTHREIYVAAAIVRWVRGEEFGVETLVMDEESRDDLGLLMNPSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6T0</accession>
    <name>A0A1W1I6T0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Urea transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NSJP_2397</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the urea transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2397"/>
    <dbReference type="EnsemblBacteria" id="SLM48569">
        <property type="protein sequence ID" value="SLM48569"/>
        <property type="gene ID" value="NSJP_2397"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2397"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004937">
        <property type="entry name" value="Urea_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10464">
        <property type="entry name" value="PTHR10464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03253">
        <property type="entry name" value="UT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016502">
        <property type="entry name" value="Urea_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="site" description="Important for channel permeability" evidence="8">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM48569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="349" mass="37602" checksum="4CE6866BD950BBA1" modified="2017-06-07" version="1">MASTAFQDQFRDHPSFGFLDWVLRGIGQVVFQNNPLSGAVILAGIFYNSWIYGTVCLLGTIISTATALFFKADKGMIKDGLFGFNGALIAIALVAYTSPNFTTGAPPNLYLGLYIVLCAAFTAVIVPAFGAILGPHKVPGLTMPFVLATWFFLGALFSFTTIDVSNALKPTSPSDFTGPRPDYTGITWFHGITMGIAEIFFQDNWVTGIVILIGIAINTRIGAAMALMGSTLAVVTAMFYGAHDEAIRDGLFGYNAALTAMALGGMFLVLNWQSFIYTVIGVLVTARVWASLGVFLEPSGMPVLTSAFVFVTWLMLLAMNGLPGLIPVAPADATTPEDNLRRYRERQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6T7</accession>
    <name>A0A1W1I6T7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2560"/>
    <dbReference type="EnsemblBacteria" id="SLM48727">
        <property type="protein sequence ID" value="SLM48727"/>
        <property type="gene ID" value="NSJP_2560"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2560"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="38"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="336" mass="39017" checksum="C03B57D46798FA8A" modified="2017-06-07" version="1">MHRTYLGRLPEQDPLHAYLRYDIQPQMTGVPGGSTYRVFRLNGSNDVYLYEDRETATKFIGKFFLSSRKNNAAKAASHLTREFDNLCTVRDYGLTGYPHHVVRPLGRHYAMNALLVTEYCEGEILSDVIRESIRHGDHGRLSHKLTALAYFLSALHNRTAVGVGVEFHYDCHYMDHLIGRLLEISAIGWDEARELYWLRDQWRNQPRMWEDQQVLVHGDATPENFMFGHNLQVVAFDLERAKRADRVFDVGRIAGELKHFFLRASGNPHAAESSIGHFLWEYACHFPDRHSAFRSITGRTPFYMGMTLLRIARNSWVEPEYRRRLINEAKACLRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6U6</accession>
    <name>A0A1W1I6U6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative dimethylaniline monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2538"/>
    <dbReference type="EnsemblBacteria" id="SLM48705">
        <property type="protein sequence ID" value="SLM48705"/>
        <property type="gene ID" value="NSJP_2538"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2538"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="414" mass="46523" checksum="370918114DF55E69" modified="2017-06-07" version="1">METKRTALLVIGAGPYGIATAAYAKYLGVPVTVVGKTLDFWKTNMPRGMFLRSGPDWHLDARDVATFQAYFKMRGLTPTQVKPVPLDMFLDYASWFMGQYDLTPRPALITHLARSNGTYTATHDDGSQIRADKVVLSLGFAWFKHYPSELENTLPVGSYMHTCDMVDFEFLRGKRVLIVGGRQSAFEWAALIQEKGADEIHVTHRHPTPRFTEPDWSWVQPMVRRTLEDHGWWRRSTSEEKEKIRSDFWAVGRLTLEAWLGPRVHQPHIHIHENTTIAATRTLADGTYEISLEDNTTVQVHHIILATGYAPNMHNVAFLDRTTILQELQTLNGSPMLDTEFQTNLSNLYVTGLAAVQDFGPFFGFTVGCPVAARIIGEAVSQCKLPGQRDTIKGELPRSSWARYMAGGRPASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6V1</accession>
    <name>A0A1W1I6V1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2557"/>
    <dbReference type="EnsemblBacteria" id="SLM48724">
        <property type="protein sequence ID" value="SLM48724"/>
        <property type="gene ID" value="NSJP_2557"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2557"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="113" mass="12950" checksum="831D06E3C78039CA" modified="2017-06-07" version="1">MHVIVEVTSQSIPSVHEQLCFAIKYKRLIRFHYQGYDRTGEPHDYGVLKDHVTVLFYQTKGGSKTGKMGWKHMNVGEIRQLQVLDDSFPGGRPVPSGKHKNWDQLFIRVDPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6X9</accession>
    <name>A0A1W1I6X9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ysc84 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48767">
        <property type="protein sequence ID" value="SLM48767"/>
        <property type="gene ID" value="NSJP_2600"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2600"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84" evidence="1">
        <location>
            <begin position="124"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="252" mass="26937" checksum="E3B8098F8C7DE715" modified="2017-06-07" version="1">MLSIRAFFADCSTPLTRIIFALRLGLCLLTGWGVLAFPVPARGTDLTDLEEVVDNARLTFAHFAGNPDLAWIRSNLKEAKGILILPQVLQAGYFVGATLGSGVLLLHDERTGEWSDPAFYTVKAGSFGLQIGLKRSQVVALIMTKKGIDSMVGSKFMLGGDLNLTVGPVGRGLAGGVTPTMNADVVAYARSEGAYGGISLRGLILSPDDDWNEVYFGRSVSASEILLSGSSVRHWYSARLRAAVTDAQTEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I763</accession>
    <name>A0A1W1I763_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative Fatty acid oxidation complex subunit alpha</fullName>
            <ecNumber evidence="11">1.1.1.35</ecNumber>
            <ecNumber evidence="11">4.2.1.17</ecNumber>
            <ecNumber evidence="11">5.1.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_2594</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="11"/>
    <dbReference type="EC" id="4.2.1.17" evidence="11"/>
    <dbReference type="EC" id="5.1.2.3" evidence="11"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2594"/>
    <dbReference type="EnsemblBacteria" id="SLM48761">
        <property type="protein sequence ID" value="SLM48761"/>
        <property type="gene ID" value="NSJP_2594"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2594"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008692">
        <property type="term" value="F:3-hydroxybutyryl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="10">
        <location>
            <begin position="340"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="9">
        <location>
            <begin position="520"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="728" mass="78820" checksum="2309761CFAE2B255" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I766</accession>
    <name>A0A1W1I766_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Segregation and condensation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">scpA</name>
        <name evidence="2" type="ORF">NSJP_2481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2481"/>
    <dbReference type="EnsemblBacteria" id="SLM48653">
        <property type="protein sequence ID" value="SLM48653"/>
        <property type="gene ID" value="NSJP_2481"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2481"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01805">
        <property type="entry name" value="ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="265" mass="30175" checksum="87CF43CDE9721EB6" modified="2017-06-07" version="1">MDNQLEGAGQTELPYQVRIENFEGPLDLLLHLIKKSEINIYDIPIALITGQYLDYLETMTELNLSVAGEFLVMAATLLQIKSKMLLPVDETVKDEDDGPDPREELVRRLLEYKSYKDAARQLDSQERMWREIYTRAPAPQEEEGPAGEETLDDVSLFDLVDALQGILNRNPGKSLMEIIPDNLTVRDRMNTILEALEGRESVSFAALFEASSHRLVIIVTFLALLELIRLRTARVYQPENFGPILVSRNFSLVPEPAELDDSEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7A9</accession>
    <name>A0A1W1I7A9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AsmA_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48896">
        <property type="protein sequence ID" value="SLM48896"/>
        <property type="gene ID" value="NSJP_2729"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2729"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032712">
        <property type="entry name" value="AsmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030925">
        <property type="entry name" value="T2SS_GspN_Lepto"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13502">
        <property type="entry name" value="AsmA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04411">
        <property type="entry name" value="T2SS_GspN_Lepto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="AsmA_2" evidence="2">
        <location>
            <begin position="121"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="300" mass="32209" checksum="66F973D739271735" modified="2017-06-07" version="1">MTLRLSWSGLANSAKEPLLWTVAGILCFVGFLFLTFPFQALQARILSEITRATGWNVRAADWSVELPLGVAWRDVTVSQSTTASFPIESMSMTVGLWGQLMGHRVLDALVHFPGSAQPGAARATGTVTASSWSFQGPTTVKAHLQQIDLSLFLRPHVAKGLLRADVDHAWIGNSDGTVSFKGDGTWRVEVADLTLEQIPAGTSRLPSLAFNRVMLTLLCHNDHCDVKEFNGEGPDGSISGQGKFRLTQPIQQTELELTLTVQAGAGWAQKSAGLPLPPLPPGTSLTFKVLGTVANPKLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7D4</accession>
    <name>A0A1W1I7D4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48723">
        <property type="protein sequence ID" value="SLM48723"/>
        <property type="gene ID" value="NSJP_2556"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2556"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="109" mass="11702" checksum="C95F14CCA3291469" modified="2017-06-07" version="1">MNQTKLGLCVAVVVCLMLAFGGPMGTLPLATAEEPQLDLNSPDVIKQVLDQQVGKRVKVKLKSGQDIEGKVARVGSHAVHLTELSGMEFFDATVKVDDVTTVIVKVRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7M9</accession>
    <name>A0A1W1I7M9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Sulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2702</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48869">
        <property type="protein sequence ID" value="SLM48869"/>
        <property type="gene ID" value="NSJP_2702"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2702"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008476">
        <property type="term" value="F:protein-tyrosine sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006478">
        <property type="term" value="P:peptidyl-tyrosine sulfation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026634">
        <property type="entry name" value="TPST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788">
        <property type="entry name" value="PTHR12788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="603" mass="67343" checksum="6FBBAA94486ADD52" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7N4</accession>
    <name>A0A1W1I7N4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2891"/>
    <dbReference type="EnsemblBacteria" id="SLM49058">
        <property type="protein sequence ID" value="SLM49058"/>
        <property type="gene ID" value="NSJP_2891"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2891"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="37"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="256"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="329" mass="36015" checksum="8C682C12D38BF019" modified="2017-06-07" version="1">MTPREAIADLQRKMESSIIGQRGVIRQILVGLLANGHLLLEGLPGLAKTRAVKSLARNLDATMSRIQFTPDLLPSDITGTEVLYQEGGKNLFKFQQGPIFGNIILADEINRAPAKVQAALLEAMEERQITVAGTTHTMPDLFMVLATQNPIEQEGTYPLPEAQLDRFLMKVLIDYPDPESEMGVLQLVRSEESAGVQPGSHGQKQEDGRISADTILAARREITGIHVSDAVARYIVDLVNATRHPDKLGEQLGKWIQVGSSPRGGIGLDRAARTNAWFEGRDHVTPDDVRAMAHGVLRHRMMLSYDANADRVTSDHVIDTLIEAVAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I827</accession>
    <name>A0A1W1I827_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tadA</name>
        <name evidence="5" type="ORF">NSJP_2987</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2987"/>
    <dbReference type="EnsemblBacteria" id="SLM49154">
        <property type="protein sequence ID" value="SLM49154"/>
        <property type="gene ID" value="NSJP_2987"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2987"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="157" mass="16997" checksum="DA8166A467684F7B" modified="2017-06-07" version="1">MSDSSVDQDTYFMRTALALAAQATAIGEVPIAAVLVQGSEVIASSHNFRETWQDPTAHAELIAIREAAKRCGTWRLLDTTLYVTVEPCPMCLGAVILARIPRLVFGARDAKAGACGSVLDFSRNSRLNHQVTVTGCVLEQDSQALLKDFFRGLRSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8A3</accession>
    <name>A0A1W1I8A3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49089">
        <property type="protein sequence ID" value="SLM49089"/>
        <property type="gene ID" value="NSJP_2922"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2922"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="59" mass="6192" checksum="575CCBA33B0A525B" modified="2017-06-07" version="1">MTQDLVVGVLLTGMVGLIWAMAVTVLWNDQGDHASSAADTPSDRDGVDETGSTRRTMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8D9</accession>
    <name>A0A1W1I8D9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Outer membrane protein TolC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3088"/>
    <dbReference type="EnsemblBacteria" id="SLM49255">
        <property type="protein sequence ID" value="SLM49255"/>
        <property type="gene ID" value="NSJP_3088"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3088"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="334"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="443" mass="49602" checksum="47EBE3CD438A58DF" modified="2017-06-07" version="1">MSVAPLRRRFLSWIFLGLSVLIISQSVAGAQQPSPPGLSGPPGPSEPPAVIRLSLNEAIALFIKQNLSVLITRYGIDYNKGQEITASLFPNPVAFIGTLSSYTQGLNLKNSGQLAMIVQQLFELAGKRGYRIESATFGTQSAEAAFEDAVRQLGFTVKDTYYRIQLAQRRLNLAEENRDRFARILDINTIRFKKGYIAEVDLIRIRLQMVDFQSQVIQSLQDAEMARGDLRQLLRLSPKTAMELTTEMDFRRIDPDINKLRVTAIDLRPDIRAKRFAQSQRESDLRLAKAYRVPDVTVGAGYEIQGAQGPDNPQQWVLNFGIPIPLFNRNQGGILQAEVAVQSAEADLNKTVNQVENEVEVAYRNLIQSRRLVEAFVGGILDDARSTLTIVERAYERGGATILDLLDAARTSRTIQQNYIEALFTYQHNLFQLESAVGQEIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8E7</accession>
    <name>A0A1W1I8E7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cysteine synthase A, O-acetylserine sulfhydrolase A subunit</fullName>
            <ecNumber evidence="6">2.5.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cysK</name>
        <name evidence="6" type="ORF">NSJP_3103</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3103"/>
    <dbReference type="EnsemblBacteria" id="SLM49270">
        <property type="protein sequence ID" value="SLM49270"/>
        <property type="gene ID" value="NSJP_3103"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3103"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="5">
        <location>
            <begin position="7"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="3">
        <location>
            <begin position="178"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="307" mass="32729" checksum="6BF0ECC7BBEAFB24" modified="2017-06-07" version="1">MPLHKEITEAIGHTPLVRLNRLSKPGCATIYGKVEFFNPGGSVKDRICLNMINEAERQGKLKPGGTIVEPTSGNTGIGLALISAVRGYKLILVMPESMSMERASLLSSYGAQLVLTPAWEGMKGSIREAESLLSQNPSYFMPDQFSNPANPAMHRMTTAPEILEAMDGKIDAFVAAVGTGGTITGCGEVFKERNPSVQIVAVEPTGSPVLSGGEPGPHKIQGIGAGFIPKVLNKKVVDRIVTVTDDEAYQTAKRISKQEGILVGISSGANVFAAQKIAEELGPGKNVVTILCDTGERYISIEKYFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8S3</accession>
    <name>A0A1W1I8S3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49448">
        <property type="protein sequence ID" value="SLM49448"/>
        <property type="gene ID" value="NSJP_3281"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3281"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="64" mass="7062" checksum="428A2AACE7977D7E" modified="2017-06-07" version="1">MAELLFVVLDDSSRTNLCLVRILAGVSQSAALAEEVPTLIQLDLHLSEPVTVFLCDRPMLAFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8T7</accession>
    <name>A0A1W1I8T7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49432">
        <property type="protein sequence ID" value="SLM49432"/>
        <property type="gene ID" value="NSJP_3265"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3265"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="75" mass="8356" checksum="03E42816AB01B858" modified="2017-06-07" version="1">MPVRPDPSFSESLSGDHRRVFYEGHRSIALFMILVVFLSPFAGLYVANLFGTVLGVILSVAAFYFTPYVWLKIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8V6</accession>
    <name>A0A1W1I8V6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49430">
        <property type="protein sequence ID" value="SLM49430"/>
        <property type="gene ID" value="NSJP_3263"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3263"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="69" mass="8066" checksum="2BCABA11620A250A" modified="2017-06-07" version="1">MMLARKLACPFEKPHNDVFSFSLHSNATHPTWRILCYRVLESYGSRQRLFTSSSESALAFTWVRREITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8V9</accession>
    <name>A0A1W1I8V9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49361">
        <property type="protein sequence ID" value="SLM49361"/>
        <property type="gene ID" value="NSJP_3194"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3194"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="135" mass="15051" checksum="2A37E30611331501" modified="2017-06-07" version="1">MTTTLREQGIDSVHDQVVSQVAQRWAKAFHCKVTIHTSLEQNPWAAPSQFCDIVGWHVTPGGQTIEWMAEVETAASLAEGQTAANWRRGIVRGIPYYLLVPRGMKEVAQKLADSTSVVFSCVYEYAFVNDICHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8W2</accession>
    <name>A0A1W1I8W2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonine ammonia-lyase</fullName>
            <ecNumber evidence="4">4.3.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tdcB</name>
        <name evidence="7" type="ORF">NSJP_3279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3279"/>
    <dbReference type="EnsemblBacteria" id="SLM49446">
        <property type="protein sequence ID" value="SLM49446"/>
        <property type="gene ID" value="NSJP_3279"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3279"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="6">
        <location>
            <begin position="327"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="402" mass="42737" checksum="E87F77E2A93D7D91" modified="2017-06-07" version="1">MVSLESIEAAASRIRSSIYESPLVHSKTLSRLTGNSIFLKLENLQMTGSFKERGALNRILTMTDAERRKGVIAASAGNHGQGVAYHATQNHIPVQIWMPRSTPLVKLTATRGYGADVVLQGNNYDDACAAALEQSRERKATFIHPFDDEAVIAGQGTIGLELLKQNPDLDVIVVPVGGGGLIGGLGCAVKERHAHVEIVGVQTARLPSMKAALEGQGTASLPAQSTLADGIAVRKAGTHTLPLVRKYVDTIVTVDEDEIAAAILVLLEREKTVAEGAGAISLAAILQSKTGHRGKNIAVLVSGGNLDVTLLARIIEQGMVRDGRRLRLRVRLPDYPGALEGLAAVIAKASANIVETSYNRAHYGVGLNEAAIDITMETRGGDHTSQLLATLKDVPYEFTVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8W6</accession>
    <name>A0A1W1I8W6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49319">
        <property type="protein sequence ID" value="SLM49319"/>
        <property type="gene ID" value="NSJP_3152"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3152"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="109" mass="11799" checksum="13D9D98930246B46" modified="2017-06-07" version="1">MISSRKHVCTVLAGFVVLLYVALAGLSTGCLFTHTVSNVGHNHHKQNSSHSTLCAWYCQATSHAALISQPPSVTAKTVGFQELLPRTIITSVRQTERIHPRGPPLQPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8X6</accession>
    <name>A0A1W1I8X6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose pyrophosphorylase</fullName>
            <shortName evidence="9">ADPGlc PPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">glgC</name>
        <name evidence="11" type="ORF">NSJP_3086</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3086"/>
    <dbReference type="EnsemblBacteria" id="SLM49253">
        <property type="protein sequence ID" value="SLM49253"/>
        <property type="gene ID" value="NSJP_3086"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3086"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00624">
        <property type="entry name" value="GlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023049">
        <property type="entry name" value="GlgC_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="10">
        <location>
            <begin position="6"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha-D-glucose 1-phosphate binding" evidence="9">
        <location>
            <begin position="177"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM49253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="412" mass="46471" checksum="E54C0396220A73A6" modified="2017-06-07" version="1">MNSIFTMVLAGGKGERLKPLTEHRAKPAVPFGGKYRIIDFTLSNCLNSGLRRVAVLIQYKSHSLDRHIRIGWNVLNAELGEYIASIPPQQRISEEWYRGTADAVYQNLFLWEGEQAEYILILAGDHIYKMNYMEMFHWLVAKNADVVVGAIDIPIQEANRFGVMTVDEDYRVTRFDEKPSNPTPLPNDPDTVFGSMGIYLFRSKSLREELIADAKEGTAHDFGKNIIPRMIANRKVYAFKFQDANRKAVKYWRDIGTLDAYWEANLDLVAVDPLFNLYDQQWPIRTYQGQFPPAKFVFAQDYQGGRMGVALDSVVCGGCIISGGRVQNSVLSPNVRVQDHSDVRDSVIMENVVIGEHSRIRRAIVDKDVVIPAKTEIGYDREADAQRFTVTESGLVVISKGMKLHASVDSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I965</accession>
    <name>A0A1W1I965_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3400"/>
    <dbReference type="EnsemblBacteria" id="SLM49567">
        <property type="protein sequence ID" value="SLM49567"/>
        <property type="gene ID" value="NSJP_3400"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3400"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013184481" evidence="1">
        <location>
            <begin position="25"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="171" mass="19113" checksum="E72817E546078789" modified="2017-06-07" version="1">MIRSHFGSALLVICWTLSSLLLTACQDRRADKAYTSGNYEKSAKELEALANLGDARAQYNLGLLYDQGLGVPQSDALALRWYTQAAERGEPRAQYNLGIMYMNGQGMAPDPVQAYFWFSLAVAQGERKASDAREYVMEQMTSEQITRGQQMVMTRLQAQPGGHQRRSDPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I973</accession>
    <name>A0A1W1I973_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dsRNA-binding protein, predicted ribosome maturation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3379"/>
    <dbReference type="EnsemblBacteria" id="SLM49546">
        <property type="protein sequence ID" value="SLM49546"/>
        <property type="gene ID" value="NSJP_3379"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3379"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="215" mass="22558" checksum="FA5B53389E1C1891" modified="2017-06-07" version="1">MATVHPLSPATIPTLASSVRSVIRDGGLIAIPTETFYGLGANPFDTAAVDRLLAIKNREEGKPILVLIGDVGQLPLLIADMPRIGHILTEAFWPGALTILLPAHPSLPLNLTARSGLVGVRLSSCVSLTELLKQIGPVTGTSANRSGHPPAATAEQVQQELGHEVDMILDAGRTAGGLPSTVVDVREPVRIVRDGAIPRQTIRNVLETHGIVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9D6</accession>
    <name>A0A1W1I9D6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49600">
        <property type="protein sequence ID" value="SLM49600"/>
        <property type="gene ID" value="NSJP_3433"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3433"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012732209" evidence="1">
        <location>
            <begin position="21"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="127" mass="13397" checksum="ADE8CFA814740F61" modified="2017-06-07" version="1">MRAFLCAALGAALLVGSANAASGEDDLLIFAVVSAPPKDRSRVAVKASVNDTVSDTKLLASESILNNLIWKKLEICHALRIEGTKAADGYKVVTVRVIDASMLPMTLQSFAGDCLIKKAIEIAPLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9F0</accession>
    <name>A0A1W1I9F0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative polysaccharide export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3445"/>
    <dbReference type="EnsemblBacteria" id="SLM49612">
        <property type="protein sequence ID" value="SLM49612"/>
        <property type="gene ID" value="NSJP_3445"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3445"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012958278" evidence="2">
        <location>
            <begin position="23"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="120"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="201" mass="22004" checksum="25313CBE33B792AC" modified="2017-06-07" version="1">MSRANFFMIAGLSLLCFVVSCAANVPAPGASDSGTAGAQIGPGYRVGSEDVLLVSVWKDEQLTREVVIRPDGMFSFPLVGDVVAEDRTVEEIRADLVKRLIKFIPNPNVSVSVMKVLSYKVYVVGRVNKPGEYLIGHYTDVLQALSLAGGLTPFAGENDIKIVRRVKGQQQVFHFRYGDVRKGHDLEQNILLQRGDVVMVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA96</accession>
    <name>A0A1W1IA96_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49978">
        <property type="protein sequence ID" value="SLM49978"/>
        <property type="gene ID" value="NSJP_3811"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3811"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="302" mass="34379" checksum="67C613A64DBC3981" modified="2017-06-07" version="1">MIGKSPCVTVGMPVYNGEHYLRQSLDSLLSQTVDDFEIVISDNASTDRTKEICSEYAEQDQRIRYFRNSTNLGAARNYNRLIALAAGPYFRWAPADDVFAPTSLERCIEVLNAHPDVVLCYPKTILIDGDGNQLEPYEDKLDLRSQDPAVRYRQALQIGRANAIYGLMRTDVLRMIAPLGSYPGADVDLLIELCLYGRYFEISEPLYFRRMHAGAYSSLTTLKDRQMFFDPTTCGKLHLSHWKRLCVRLAAVWRAPVGLRARLTISYKLVRGAVTSRKEFVNEVVQILRTKGPKRWLEDQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAG8</accession>
    <name>A0A1W1IAG8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 3-oxoadipate enol-lactonase</fullName>
            <ecNumber evidence="2">3.1.1.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.24" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3744"/>
    <dbReference type="EnsemblBacteria" id="SLM49911">
        <property type="protein sequence ID" value="SLM49911"/>
        <property type="gene ID" value="NSJP_3744"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3744"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047570">
        <property type="term" value="F:3-oxoadipate enol-lactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="271" mass="29602" checksum="122EAF15DA192072" modified="2017-06-07" version="1">MPVVHVVGSGTALHYRESGDPDNPTIVFAHPLIWGGDSFGELLAGLTDEFHVVTVDIHGHGLSGYRETMTLEEMTEDFYHVLQSLHVPKVSWLGYSIGGMIGMRLAIAHPDVLDSLVLVATTARPDPSTIKAATFHLWKMFRDGHRKDIVDSAMKFFFADRTYREQPELIAKCRAKFVGITDAQGMFAAALAAFNRFDIGSQIRRIATPTLVIAGREDPAATPALADSIAAQIPKAKLEIVEGTSHLVGIEKPLEVTALVRGFLRTSTQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAH5</accession>
    <name>A0A1W1IAH5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49879">
        <property type="protein sequence ID" value="SLM49879"/>
        <property type="gene ID" value="NSJP_3712"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3712"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="263" mass="30788" checksum="6AD459702188ED4D" modified="2017-06-07" version="1">MGDKMRTVRHRRESGRILVGTSGWTYGSWKGLFYPVGLPNARWLEFFTGQFPTTEVNYSFYHLPKPSTYEKWASQVPQDFIFSVKASRYITHVKRLKDVEDPWRLFLSHARSLGTHLGPILFQFPESFHRDDDRLKDFLEMVRRGSSRLRLVCEFRHESWFSTGVYRLLNRLGAALCIGDSGRYPRRDVVTADFAYVRFHGRSRLFASNYTRRELDEEARKVKGYLRDGYDAYVYFNNDAEGHAVANAKTFMGLIEKPSVRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAV6</accession>
    <name>A0A1W1IAV6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50132">
        <property type="protein sequence ID" value="SLM50132"/>
        <property type="gene ID" value="NSJP_3965"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3965"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="110" mass="12079" checksum="1AA8D680EA8E2117" modified="2017-06-07" version="1">MKWCLLRSGPTKGDLKIEQNGSDQNHAMEGTGNTPSNFRSPPHTGAGRLPHSKAWHRGQDERRLGQQGGMNLIELLGAGKALAKEACHFMPTPRDSMAGRKSVNRSHFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAX7</accession>
    <name>A0A1W1IAX7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Asparagine synthetase</fullName>
            <ecNumber evidence="8">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_4021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50188">
        <property type="protein sequence ID" value="SLM50188"/>
        <property type="gene ID" value="NSJP_4021"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4021"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="7">
        <location>
            <begin position="2"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="364"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM50188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="639" mass="73455" checksum="E6F77A8A524C87A2" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAY8</accession>
    <name>A0A1W1IAY8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4031"/>
    <dbReference type="EnsemblBacteria" id="SLM50198">
        <property type="protein sequence ID" value="SLM50198"/>
        <property type="gene ID" value="NSJP_4031"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4031"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046031">
        <property type="entry name" value="DUF5989"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19451">
        <property type="entry name" value="DUF5989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="50" mass="5813" checksum="D8922AFE1B9A74E8" modified="2017-06-07" version="1">MGEFLQELWAFMRERKKFWLLPIILVLVLLGSLIVLTQGSAVAPFIYTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB58</accession>
    <name>A0A1W1IB58_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphomannomutase/phosphoglucomutase</fullName>
            <ecNumber evidence="9">5.4.2.2</ecNumber>
            <ecNumber evidence="9">5.4.2.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">algC</name>
        <name evidence="9" type="ORF">NSJP_4120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="9"/>
    <dbReference type="EC" id="5.4.2.8" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4120"/>
    <dbReference type="EnsemblBacteria" id="SLM50287">
        <property type="protein sequence ID" value="SLM50287"/>
        <property type="gene ID" value="NSJP_4120"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4120"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="6">
        <location>
            <begin position="3"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="7">
        <location>
            <begin position="149"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="8">
        <location>
            <begin position="252"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="5">
        <location>
            <begin position="368"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM50287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="466" mass="51033" checksum="0B6B47B5B4E770D9" modified="2017-06-07" version="1">MGLFREYDLRGIVGKELTEPIAEQVGRAYATYVNDRGVKTISVGRDGRLSSPGLFQALVRGLLAGGMNVVDVGICPSPLVYFSLFTLPIEGGIMITGSHNAAEYNGFKICVGKEAIHGEAIQDLRRILEAGRFVSGQGRLSEHPIIPDYLAYIKRSFPDVNGKRLHVVIDCGNGVAALVAKQALELLGCRVTGLYCDLDGRFPNHHPDPTVLENLQDLMAAVKQHQADVGIGYDGDADRIGAIDEQGQVLWGDRLLVVYARDILAAKPGSTIISEVKASQCLYDDIAKQGGRPVMWKTGHSLIKSKMKSEKAVLAGEMSGHMFFADRYFGYDDAIYASCRLIEILSKSPRPLSSLVADLPQTSVTPEIRVDMPDAVKFDVVKRVHERFAGYLKTRHEIGQHRLPLRDLVTIDGVRAIFDDGWGLIRASNTQPALVLRFEATSPARLDVIRTTVEHELADAKTSLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBC8</accession>
    <name>A0A1W1IBC8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diaminobutyrate--2-oxoglutarate aminotransferase</fullName>
            <ecNumber evidence="5">2.6.1.76</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rhbA</name>
        <name evidence="5" type="ORF">NSJP_3906</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.76" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3906"/>
    <dbReference type="EnsemblBacteria" id="SLM50073">
        <property type="protein sequence ID" value="SLM50073"/>
        <property type="gene ID" value="NSJP_3906"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3906"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045303">
        <property type="term" value="F:diaminobutyrate-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004637">
        <property type="entry name" value="Dat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43552">
        <property type="entry name" value="PTHR43552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00709">
        <property type="entry name" value="dat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM50073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="468" mass="50891" checksum="AD1E5CBE23A781F4" modified="2017-06-07" version="1">MTVHVDDMRHTFSTSRKAPPAEQRVNPYLERQTERESNARSYPRRLPLALRKAKGIYVEDTDGRTYIDCLACAGALALGHNHPVVLEAIQRFLEDGVPFQTLDLTTPVKDQFVDSLFAALPKTFAEDARIQFCGPSGADAVEAAIKLVKTVTGRRTILSFQGAYHGMTHGGLALTGHLGPKSAVSGLMPDVQFLPYPYEYRCPFGTGGESGHRLSSTYIERLLDDPNSGVVSPAAMILEVVQGEGGVIPCPDAWLQDIRRITRERKIPLIVDEIQTGLGRTGTLLAFERAGITPDVLVMSKAIGGGLPLSVVVYRPELDLWQPGAHAGTFRGNQMAMAAGAATIEFVRTHRLDQHAQIMGERLLTHLRALQASSRSLGDVRGRGLMIGVEVVDTDARPDARGTYPAAPEMARKIQTEALRRGLILELGGRNGCVVRFLSPLVVTEEEIDLIASIFGEAVVAAERDART</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBE1</accession>
    <name>A0A1W1IBE1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_4064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4064"/>
    <dbReference type="EnsemblBacteria" id="SLM50231">
        <property type="protein sequence ID" value="SLM50231"/>
        <property type="gene ID" value="NSJP_4064"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4064"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="47"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM50231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="292" mass="32384" checksum="13BB163142FDE2B1" modified="2017-06-07" version="1">MTAAKDIFAPTPTLQVDVAGGHRILIEPTSSLFHLDFGAIWMHRELLLFLAWRDVKARYAQTAMGIGWALVQPLLSMAIFTVIFSYWAKLPSDGLPYPLFAFAALLPWLYFSRSLDKSAGSLVAEAGLIKKVYFPRVIIPISATLVGLVDFFVGLVLLIGMMIWYGVVPTYGVLALPFLLLLALASSLAVSLWLSAIHVKYRDIGAVLPLIIQLWMYASPVVYSVNMVPEKWRPLYSLNPMVGVIEGFRWALLGKVSPDFLAIGVSTGVVIMLLLGGLLYFKWMERTFADVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZL0</accession>
    <name>A0A1W1HZL0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2062 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0026"/>
    <dbReference type="EnsemblBacteria" id="SLM46198">
        <property type="protein sequence ID" value="SLM46198"/>
        <property type="gene ID" value="NSJP_0026"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0026"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018639">
        <property type="entry name" value="DUF2062"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09835">
        <property type="entry name" value="DUF2062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2062" evidence="3">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="176" mass="19436" checksum="1E8A062E871FD787" modified="2017-06-07" version="1">MPRFRSLMRQLLHLQESPERTAMAFAIGVAIAFCPLYGLHMALVVFCTWAFGLNFVALMAGALVNNPWTIVPVLGATYWTGALILGRTEVPTFDWHDLSFMAVYQQVLPYAIPFLLGGTILSLAGALLAYPMAYRLISKYRRSSHPTEHRSIQQAAAQSPLGTSHPEPLPPRDPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZU8</accession>
    <name>A0A1W1HZU8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0099"/>
    <dbReference type="EnsemblBacteria" id="SLM46271">
        <property type="protein sequence ID" value="SLM46271"/>
        <property type="gene ID" value="NSJP_0099"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0099"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="397" mass="44373" checksum="E97C6BC8FEBEFEE6" modified="2017-06-07" version="1">MRIRFCKLGVLPAIGFLILGLSGCLSPIALNRAVVAYDEAVTDTVSKQLLINIARAHHHQPIHFSGVSNIAATFDFRFSAGATPALTGEASRAIMPVFGGSVAENPTISIAPIEGEEFTKRLLTPFQETKFLLLLRQGVDIDLLLRLMAKELRVKEGGEDVAYRNNPTDRSGYDMFRKAVLHLSSIQDANRLYAESLVFERVWTIPAESVTAEGFKALEQDYFVTYSATEKTYTLRKPVSGRVLITNYDPDTLSDEERTAFHETAEQHLPNDVSFDIRPGPFGGEWPLHGEFRLRSFNAMLNFLGASVDEELEYPVDKDPRTSEVAENPVRTLDLLVQETSPQGADLTVYSHGRHYAVNATGPQGRWNREAFKLLFQLFQMTVTEIPRRDLPITIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I018</accession>
    <name>A0A1W1I018_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease HII</fullName>
            <shortName evidence="11">RNase HII</shortName>
            <ecNumber evidence="11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">rnhB</name>
        <name evidence="14" type="ORF">NSJP_0057</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11 12">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="11"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0057"/>
    <dbReference type="EnsemblBacteria" id="SLM46229">
        <property type="protein sequence ID" value="SLM46229"/>
        <property type="gene ID" value="NSJP_0057"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0057"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="20"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM46229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="224" mass="24656" checksum="C1FE9CB40AFC3917" modified="2017-06-07" version="1">MGPTDEFELEARRCGYRRIAGLDEAGRGPLAGPVVAAAVILPSRCRLAGIDDSKQLTEPERNHLFILITQRAVAIGVGSASHEEIDRVNILEATRLAMYRAVAALSLVPDCLLIDAVSLPRARLPVRSIIKGDALSVSIAAASIVAKVTRDRLMAEYHAVYPQYNFLSHKGYGTEEHRQRLSEHGPSEIHRRTFAPVANILAPRPVPHIDMSFMDMDEQFSENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I075</accession>
    <name>A0A1W1I075_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metal-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0195"/>
    <dbReference type="EnsemblBacteria" id="SLM46367">
        <property type="protein sequence ID" value="SLM46367"/>
        <property type="gene ID" value="NSJP_0195"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0195"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="15"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="212" mass="23259" checksum="1585B3D77D9353E5" modified="2017-06-07" version="1">MADFIRKTFSVPPLGCNCSILGDPVSRQAIVVDPGGAHERILSEVRQLGLSVAVVLHTHAHFDHFLASGEIKKATGAALCLHPADRELWTMLDVQCRMFGVPYVPVPPPDHWLQDEEKIAFGSETAVALHTPGHTPGSMSFHLPGQKLVLAGDTLFRGSIGRTDLWGGDFDTIERSIRERLYTLEDGTVVVTGHGAETEIGWEKQSNQFIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I098</accession>
    <name>A0A1W1I098_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_0256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0256"/>
    <dbReference type="EnsemblBacteria" id="SLM46428">
        <property type="protein sequence ID" value="SLM46428"/>
        <property type="gene ID" value="NSJP_0256"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0256"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="254" mass="27648" checksum="0792F7456170AE22" modified="2017-06-07" version="1">MHYILAVAGNTFRETLRDKILYNLVLFALLLIGASVLLATLTIGEQARIVKDIGLASINIVGVIIAIFVGIGLVAKEIERRTIYTILARPITRSQFLIGKYLGLAVVIAMNMGLMFGMFLITVWVSNAPISESLFQSVQLMVVESLLIVAVAIFFSTFTSSILSATMTLGVYVIGHLTNDMKAIAAKSQNPITEGIMTAIYYVCPNLEWLNIKGQASSGVAVSMTYQALATSYGLLYSGLLLAAACLFFRRRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0B1</accession>
    <name>A0A1W1I0B1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RNA-binding protein RbpF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rbpF</name>
        <name evidence="3" type="ORF">NSJP_0157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0157"/>
    <dbReference type="EnsemblBacteria" id="SLM46329">
        <property type="protein sequence ID" value="SLM46329"/>
        <property type="gene ID" value="NSJP_0157"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0157"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="110" mass="11168" checksum="E7379F74B59D9812" modified="2017-06-07" version="1">MGSKIYVGGLPYSATEQQLSDLFAVHGGVASARIITDKFTGQSRGFGFVEMSSDSEAQAAITALNGSEMGGRTLTVNEARPQEPRAGGGGGGRGGFGGGRSGGGGKRDRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0E0</accession>
    <name>A0A1W1I0E0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Twitching motility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pilT</name>
        <name evidence="3" type="ORF">NSJP_0270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0270"/>
    <dbReference type="EnsemblBacteria" id="SLM46442">
        <property type="protein sequence ID" value="SLM46442"/>
        <property type="gene ID" value="NSJP_0270"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0270"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01131">
        <property type="entry name" value="PilT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="352" mass="38488" checksum="8C9C0F7D629AF501" modified="2017-06-07" version="1">MDISKLLTFSAKEGASDCHISAGEPPMIRLHGDLKKLDHPPLTSEETHALIYDMMSDAQRKTFEEKRECDFSFELGDIARFRVNVFVQNRGLGAVFRNIPTEIIPMEKLGMPPILRQLCDKEKGLILVTGPTGSGKSTTLASMVDYLNNTFEGHIITIEDPIEFVHKTKKCLVNQRELGVHTLSFANALRSALREDPDIVLVGEMRDLETIQLALTAAETGHLVFGTLHTSSAPKTIDRIIDAFPPAQQAQVRTQLSEALEAVITQTLLKKKAGGRVAALEIMVATTAIRNLIREAKLHQIPGIMQASQRDGMQTMDMALIDLAARGVVTKGEAQSRSMNPNLFGGPAVGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0U0</accession>
    <name>A0A1W1I0U0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oxidored_molyb domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0317"/>
    <dbReference type="EnsemblBacteria" id="SLM46489">
        <property type="protein sequence ID" value="SLM46489"/>
        <property type="gene ID" value="NSJP_0317"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0317"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_molyb" evidence="1">
        <location>
            <begin position="94"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="256" mass="28141" checksum="24766184E6B15F67" modified="2017-06-07" version="1">MTPKHGMKRREILKGTLGATSVIALAGCDNLTRSDWFAELLSRAETLTELVQRAVTPVGAMAKEYREADISAVFPANGNIDPGTQKYAEMVRDEFARWEVTVGGLVQAPASFSIGALKAMPARTQITRHDCVEGWSAIGKWTGVPLGDLMRQVRPTPGARYAVFHCADIDEQGVAYYESVAVEDLYHPQTILAYELNGKALDVPHGAPLRLRLERQLGYKHAKYVERIELVASLDGIGGGKGGYWEDQGYEWYAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Z9</accession>
    <name>A0A1W1I0Z9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asparagine synthetase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0489"/>
    <dbReference type="EnsemblBacteria" id="SLM46661">
        <property type="protein sequence ID" value="SLM46661"/>
        <property type="gene ID" value="NSJP_0489"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0489"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01990">
        <property type="entry name" value="Alpha_ANH_like_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005232">
        <property type="entry name" value="LarE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43169:SF2">
        <property type="entry name" value="PTHR43169:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006661">
        <property type="entry name" value="PP-lp_UCP006661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00268">
        <property type="entry name" value="TIGR00268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile and sulfur donor" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006661-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="271" mass="29893" checksum="8F3FCD6CC9F1D98B" modified="2017-06-07" version="1">MNMSPDHLADKLVRLRSILSDMQSVLVAFSGGIDSTLVLKIAHEELGSRALGVTAVSPTFPLLELETATRVAREIGARHEIVRTDQLTISAFVQNDATRCFHCKTDLYRLMDGMKGPRTSRWVADGTNLDDLGDDRPGITAARQWQVRSPLVEAELSKSDVRTLARAFGISTWDKPAAACLSSRIPHGTPITVEKLARVEQAEAILSAEGFRHVRVRDHGEIARLEVGTEEFSRFLEPDLRARIGARLRETGFRFICLDVEGYRSGGVSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I135</accession>
    <name>A0A1W1I135_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="2">N5-CAIR mutase</shortName>
            <ecNumber evidence="2">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">purE</name>
        <name evidence="5" type="ORF">NSJP_0522</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0522"/>
    <dbReference type="EnsemblBacteria" id="SLM46694">
        <property type="protein sequence ID" value="SLM46694"/>
        <property type="gene ID" value="NSJP_0522"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0522"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="4">
        <location>
            <begin position="24"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="200" mass="21101" checksum="003B7395CBE56644" modified="2017-06-07" version="1">MKSTTSSRSRRNHNRGAGLRATQPIVGVLGGSKSDFPILEKATALLGELGVPHELLVVSAHRTPDRLFAYAEQAASRGIEVIIAGAGGAAHLPGMLAAKTHLPVIGVPIPTEHLRGLDSLLSIVQMPRGIPVATVAIGGAENAGLLAAQILGGRYPDVAARVRDFRRTQTESVLNSPEAQGVVDGASWDNRPPRRPRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I143</accession>
    <name>A0A1W1I143_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvoyl-dependent arginine decarboxylase AaxB</fullName>
            <ecNumber evidence="4">4.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pdaD</name>
        <name evidence="9" type="ORF">NSJP_0529</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + L-arginine = agmatine + CO2</text>
            <dbReference type="Rhea" id="RHEA:17641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="EC" id="4.1.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pyruvoyl-dependent arginine decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0529"/>
    <dbReference type="EnsemblBacteria" id="SLM46701">
        <property type="protein sequence ID" value="SLM46701"/>
        <property type="gene ID" value="NSJP_0529"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0529"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01404">
        <property type="entry name" value="PvlArgDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016104">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016105">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase_sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002724">
        <property type="entry name" value="Pyruvoyl-dep_arg_deCO2ase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40438">
        <property type="entry name" value="PTHR40438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01862">
        <property type="entry name" value="PvlArgDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005216">
        <property type="entry name" value="Pyruvoyl-dep_arg_deCO2ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01170">
        <property type="entry name" value="Pyruvoyl-dependent_arginine_de"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56271">
        <property type="entry name" value="SSF56271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00286">
        <property type="entry name" value="TIGR00286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="189" mass="21024" checksum="7627877BB8D89F9D" modified="2017-06-07" version="1">MVPTHMFLTRGVGVHREKLASFEQALRSAGVAYCNLVSVSSILPPNCKIIPRKRGEKLLNPGEITHCVMARSETNERNRLVSASIGLAIPTDRRTYGYLSEHHAHGETDEETGEYTEDLAAQMLATTLGVEFDPNIAWKEREQVFKMAGKIVRTLNITQSAIGKPGKWTTVVALAVFIPLENLPKRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1G7</accession>
    <name>A0A1W1I1G7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4149 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_0676</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46848">
        <property type="protein sequence ID" value="SLM46848"/>
        <property type="gene ID" value="NSJP_0676"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0676"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="DUF4149"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4149" evidence="5">
        <location>
            <begin position="11"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="155" mass="16598" checksum="17E9CA4B4DBB4673" modified="2017-06-07" version="1">MVPLMEYLSMLAVAVLVGKVILLSFVVAPVLAKNLEAEAFGKVVRQLFPAYYALGIGAAGAGLVLVIMRGIAGETDALHHLAAGLWLAVIAAETYCRAPLTPQSNALRDRLKAQESRGAVDPVLQQTWNRLHRRSVYLNSLVLLLGLGLLGLASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1L5</accession>
    <name>A0A1W1I1L5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46885">
        <property type="protein sequence ID" value="SLM46885"/>
        <property type="gene ID" value="NSJP_0713"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0713"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012574129" evidence="1">
        <location>
            <begin position="32"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="194" mass="21838" checksum="6D69C9412EB17C51" modified="2017-06-07" version="1">MRAATRYRSVLPRKFLAGVLLCLPTLSPALGEDIPLTKNSSISEFQNRSEDTRPYDFDAPPKGMFRDITMAEGFDEEIGIHRTHEIVPVKPTDHFTAESTGIFIVFQLHQHYQAFQIFGRCFPETVAGLNPDTMIGQDAMYIALEDESGYLRLTPPTGGWRPGRYKVEIHAGEQVNEMSLMGTMRFTVVADLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1P5</accession>
    <name>A0A1W1I1P5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-nucleotidase SurE</fullName>
            <ecNumber evidence="5">3.1.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nucleoside 5'-monophosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">surE</name>
        <name evidence="7" type="ORF">NSJP_0743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0743"/>
    <dbReference type="EnsemblBacteria" id="SLM46915">
        <property type="protein sequence ID" value="SLM46915"/>
        <property type="gene ID" value="NSJP_0743"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0743"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00060">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SurE" evidence="6">
        <location>
            <begin position="35"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="296" mass="32785" checksum="6713DE5ABF9C8204" modified="2017-06-07" version="1">MYTRRSLRLAPDIRTSVRLSCRCAAFFVPDVHMRILVTNDDGMASAGLTALAEALGKLGDVWVVAPDRERTAVGHAVTLHKPLRIHRQAKRAFAINGTPVDCVNLAIQNILPGLPQLLVSGINKGVNLGDDVLYSGTVSAAVEGTILGIPSIAVSQEGRDTFRFSAGAHHAMRIARLVLEQGLPEETLLNVNIPDRPLARTTGVRVTCLSRRRFDDPIIEKVDPHGRTYYWIAGTRVSWSRNKDSDHEAIAEGAVSMTPIRLDSTHYDAMDRFRAWESLLKHSNRRTRSPRMKRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Z8</accession>
    <name>A0A1W1I1Z8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_0840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0840"/>
    <dbReference type="EnsemblBacteria" id="SLM47012">
        <property type="protein sequence ID" value="SLM47012"/>
        <property type="gene ID" value="NSJP_0840"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0840"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="PTHR33146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="SSF48537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="360" mass="39684" checksum="B0CAB1F802061114" modified="2017-06-07" version="1">MQLFLLWIMALLVWPHDASAWESLGHEAIADAAQEHLSPETAKSIAQILGHGATLPPHALAKASTWPDQIRDLQRHGTAASKLDEHGVKEAQAFNAAFPDNAQWHFVNLPLGSAHYPDDADLDDLLTPFTSPHDVVQMLNVCIETLETVGEVTPWTKTQALRWLIHLVGDVHQPLHVATGYYRTTHQDLPNPVLIENPHDAGRVGVLGDRGGNDLLFSDSARDNLHALWDSCLVKALAGIGACGKAPTAEDAARLVHRIIQRMKLASSFDYRSSGEHFSWAAHWATDSLKTARESKAYAFVRRNGIVRDSHMADASIRMTIDAPPTKTEYSTNHEPVVETQLTKAAVRLADLLNHLAWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I265</accession>
    <name>A0A1W1I265_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47085">
        <property type="protein sequence ID" value="SLM47085"/>
        <property type="gene ID" value="NSJP_0913"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0913"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="50" mass="5391" checksum="547F98C25049637C" modified="2017-06-07" version="1">MTLVIPRVADLTAVLLTAPLNILQAVSEAMRSDVRKIQPRVSASAIGYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I274</accession>
    <name>A0A1W1I274_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47095">
        <property type="protein sequence ID" value="SLM47095"/>
        <property type="gene ID" value="NSJP_0923"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0923"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044245">
        <property type="entry name" value="Spartan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220">
        <property type="entry name" value="PTHR21220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="2">
        <location>
            <begin position="12"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="209" mass="23786" checksum="EDD40A78091C52ED" modified="2017-06-07" version="1">MASSPTPPLTTDELTAIWFDLNVRYFDGALPPIDLVWSRRLTSSIGMFVSRGGPRSSWSETASAKPPRREIRLSLPLLTPLLAGSPHGFTELLSTVAHEMIHQWQYDILKRRPSHGPDFLRKMSEVNRDGSLAVSLYHSLQQEVLALARFAWRCRQCGRIYRRQRRTIQPRRHHCGSCRGALQELGAVRRIESPVPRPSPDRAQLSLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2A1</accession>
    <name>A0A1W1I2A1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47140">
        <property type="protein sequence ID" value="SLM47140"/>
        <property type="gene ID" value="NSJP_0968"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0968"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="170" mass="19032" checksum="D6F07E0D86CB3637" modified="2017-06-07" version="1">MIGAHACRDHKAMIQQVYMRRSIGRTILLCLLLCVGVGCAKPVLKDSMPAPASLPADAGEDRRVLAGEWEYEEGAVVILRLDEQGNGTYAWKDGRFTTTALTGRIWEGLWSQRENDREGGFRVEFSPDFSEGEGRWWYTRIGQDHTPSQKGGTFHVSRKSEGMSRGETPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2L9</accession>
    <name>A0A1W1I2L9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="2">2.7.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cysC</name>
        <name evidence="2" type="ORF">NSJP_1070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.25" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1070"/>
    <dbReference type="EnsemblBacteria" id="SLM47242">
        <property type="protein sequence ID" value="SLM47242"/>
        <property type="gene ID" value="NSJP_1070"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1070"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="210" mass="23580" checksum="1998CD64F8FBEB3E" modified="2017-06-07" version="1">MSIADDGVRGYIDEKLTARRRLNPDPTSPTTHRVLPFAIWLTGLPASGKSTIVSLLRPELEALDLTVEVLESDEVRHILTPAPTYSETERDLFYRALAFLGARLVAHGITVVFDATATRRMYRNLARTLIPRLIEVSVECPLEVCMQRDYKGTYHRGQHGDTSTVPGLQVPYEPPTDPELRIDTTTVTPAEAARRIIALVRTRLFTQEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2S7</accession>
    <name>A0A1W1I2S7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yhhJ</name>
        <name evidence="7" type="ORF">NSJP_1103</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1103"/>
    <dbReference type="EnsemblBacteria" id="SLM47275">
        <property type="protein sequence ID" value="SLM47275"/>
        <property type="gene ID" value="NSJP_1103"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1103"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="389" mass="43126" checksum="436A66029767FBC4" modified="2017-06-07" version="1">MTGDIRTDAHRTVRWWRRLAAMTQKEVRQLGRDIPLLVFLLYSFSFSVYVSGVGLTMQLRNADLMVHDADHSLSSRELIHRFQQPYFRFRGEIADPREGRRHMDEGTTMVLLDIPPRFHEALAGREATAVQLLVDTTNAPQGLSAAGYAAQIVSRFGSEVGFASVGLGSTPSSVPMIVSAHRVWFNPNQDETWFQSISHLLRTITVFAVLLPAVALVREKERGTLEQLLVAPLSPVQIMLSKVLAMTGVILLCASIAVYGVLRPVFHVPIKGPAWLFFLLTGLHVFTTSGFGLVAATVTRNQAQVGMIALFLVGPMMLLSGITTPYESMPKWVQTVMAVSPLRYYIDITYGVLLKGAGLDVLWKSVGTMALLGGGLFVFGMWRFRKQFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2T5</accession>
    <name>A0A1W1I2T5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1145"/>
    <dbReference type="EnsemblBacteria" id="SLM47317">
        <property type="protein sequence ID" value="SLM47317"/>
        <property type="gene ID" value="NSJP_1145"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1145"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="22"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="345" mass="37927" checksum="45EE26435765D090" modified="2017-06-07" version="1">MTRRDIPLGFRADGTELRIPPVGSNLLIAGTSGSGKSSLAHGLLERLSDCGYQVCIIDPEGDYASVDQVIVFGNPQRGPSIEEVLTALDSPTAQVAVNLVGLPLKDRPAFFSDLLPRIQERQAQIGRPHRILIDEAHHLMPKQWEPASELTGRMTGMIFVTVHPEEVSSGVLRSVDAAVAMGEDPARTLGAYAERVGLSLPAGSWTLDQGEAVVWPVRTGGMPEQFGIAPSRGERRRHLRKYAEGELPQDRSFYFRGPREELNLRAQNLMLFCQLADGIDDATWLYHLQRHDYSNWIEGSIKDSDLAGIVRDVESLPSLSARESRLRIAQAIEARYTLPASGAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2U7</accession>
    <name>A0A1W1I2U7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized oxidoreductase YhdF</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhdF</name>
        <name evidence="2" type="ORF">NSJP_1158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47330">
        <property type="protein sequence ID" value="SLM47330"/>
        <property type="gene ID" value="NSJP_1158"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1158"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="289" mass="31474" checksum="F732FE5D0947BFC6" modified="2017-06-07" version="1">MVMTETKKIQRPPQRQKGQPGQEDEMTPRPASDRETRHGSGKLRDKVVLITGGDSGIGRAAAIAYAREGGDVSIVYLNEHKDAEDTKRLVEQEGRRCLTIAGDIGDEAFCRSAVERTVKEFGRLDVLVNNAAEQHPQDRLEEITAEQLERTFRTNIFSFFYMSKAALPHLKEGSAIVNTTSVTSYKGSAHLLDYASTKGAIVAFTRSLSQALADRKIRVNAVAPGPIWTPLIPATFPADKVATFGSDVPMKRAGQPEEVAPSFVFLASEDSSYMTGQVLHPNGGTIVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I300</accession>
    <name>A0A1W1I300_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Permease, MFS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47377">
        <property type="protein sequence ID" value="SLM47377"/>
        <property type="gene ID" value="NSJP_1205"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1205"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="439" mass="46477" checksum="B7E64584652C8808" modified="2017-06-07" version="1">MTRALPNDRPDVSEEPSGTSGWGLLKTRNFALLFWGQMTSQVGDSLNRVALLWFVYQLTGSAMKMVVIGLLQTIPPLVLGPLIGVYLDRVDKKSVMIKVDLARTFLVLMIPVLYAIGELSLERLYVAVFLLAIVSTVFGPALSSSVPQIVRRDQLTSANALLQTTTNVGLLIGPLISGIGIALVGSQNVLYVNAATFFVSALCLVGIRLRPMPKEMAADESARGSWKQELMAGIRFVCFDQSMLVLMLAAALYSLAASAFAFMLPVFAEQNLSAGALELGILWSALGAGMLATSTWLASLAQGDLTRRFTLIFRSMVVGGLAMCGLSVLTAPLVAGALILIIGGSTALFMPIVWGVLQEVTPAPLLGRVFTTFSTGSMASAMAGMAGFGWAADTMGPHVSLLGIGLVLLVTACAAALSSRQFRRLAGVYRPQPAGELAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I342</accession>
    <name>A0A1W1I342_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47426">
        <property type="protein sequence ID" value="SLM47426"/>
        <property type="gene ID" value="NSJP_1254"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1254"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="125" mass="14215" checksum="380D6BA03BE990F6" modified="2017-06-07" version="1">MNDTKRIYRGGWTHFLGSTVAFATLTASETWLRHAESNDQSSAQFRRTETGMHFDKIYQVTIDTPQVVKADLILRSVYGVLFSQSLVFRSAGILRDHTSSSRGYGSSFTQSWIVDISRTSFLRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3I0</accession>
    <name>A0A1W1I3I0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_1372</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47544">
        <property type="protein sequence ID" value="SLM47544"/>
        <property type="gene ID" value="NSJP_1372"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1372"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019494">
        <property type="entry name" value="FIST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013702">
        <property type="entry name" value="FIST_domain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016741">
        <property type="entry name" value="UCP018953"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08495">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10442">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018953">
        <property type="entry name" value="UCP018953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00897">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01204">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FIST" evidence="7">
        <location>
            <begin position="44"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="FIST_C" evidence="8">
        <location>
            <begin position="236"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="405" mass="43651" checksum="8476155D9AB463C4" modified="2017-06-07" version="1">MSYATHTEASTALRFAVALSRKTDTEAALRDLADMIRDQIGNAPVDLAFVFFSAHHAAKAELIAPMIREELHVHTCLGCSGEGIIAGGEELETAAGLTLWVARLPRVSVTPLRLSFSETQDQIHMPGWPEPTAGDSTFILLADPFTTPLHDVLTVLNDRYPGGKAVGGLVGGGHGRGENRLIRNDELFDGGLVGVHLSGPLSVRTVISQGCRPIGDRFVVTKSEQNLVYELGGQPALTRLQDVFESLESSQRRDAHQALHVGIVIDEHRDRFEQGDFLVRNLVGADQRSGAIAIGDTVQEGQTVQFHIRDAKSASDDLHFLLAADRRKHPRPPLGSLLFSCCGRGEGLFGRPNHDSTVVQERLGQVPLAGFFAQGEIGPVGGRNFLHGYTASLALFAEPETSGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3M1</accession>
    <name>A0A1W1I3M1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase TesA</fullName>
            <ecNumber evidence="3">3.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tesA</name>
        <name evidence="3" type="ORF">NSJP_1393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1393"/>
    <dbReference type="EnsemblBacteria" id="SLM47565">
        <property type="protein sequence ID" value="SLM47565"/>
        <property type="gene ID" value="NSJP_1393"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1393"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080030">
        <property type="term" value="F:methyl indole-3-acetate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013207073" evidence="1">
        <location>
            <begin position="23"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="41"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="220" mass="23495" checksum="9E19DB89A640EC48" modified="2017-06-07" version="1">MASLNIATAARCMVLASLLVGAAAAPTLAEAPADVRPKLVAFGDSLTSGLGVAAADAYPAQLQRRLDEAGFRYRVINAGVSGDTTAGGLRRVRWILNSRPTLVILELGGNDGLRGLSLAETRRNLELIVEQLQQASVTVVLAGMKLPPNYGQEYTQGFEEIYPALARRYRLKLIPFFLEGIAGDTALNQADGIHPTAEGYHIIVGNLFESLKPILKRQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3P4</accession>
    <name>A0A1W1I3P4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rpmI</name>
        <name evidence="7" type="ORF">NSJP_1454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1454"/>
    <dbReference type="EnsemblBacteria" id="SLM47626">
        <property type="protein sequence ID" value="SLM47626"/>
        <property type="gene ID" value="NSJP_1454"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1454"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="64" mass="7220" checksum="A8963A1170ACF5B1" modified="2017-06-07" version="1">MKMKSHSGASKRFHKTGTGKFVRKKAGKRHILTSKNRERKRRLSGSVVVDPTKASALARLLPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3R9</accession>
    <name>A0A1W1I3R9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">cmk</name>
        <name evidence="10" type="ORF">NSJP_1478</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1478"/>
    <dbReference type="EnsemblBacteria" id="SLM47650">
        <property type="protein sequence ID" value="SLM47650"/>
        <property type="gene ID" value="NSJP_1478"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1478"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="9">
        <location>
            <begin position="3"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="7"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="219" mass="23490" checksum="B656C02F3B81F5F3" modified="2017-06-07" version="1">MIVAIDGPAGVGKSTVARLLAGRLKYLYLDTGALYRAVAWTVLQRGVDMADQKAVAALLPLTSLKMEFENETVVVRVNDKDVTGELRSPAVSASASVVSAIPAVRAWLLPVQRSIGERGSVVAEGRDIGTKVFPSAPVKFFLEADPTVRAERRHRELVAAGHAREIEQTSTEMAGRDSRDRSRAVAPLVPAEDAHHIDTSRLSAAEVVDLMMGIIAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3S6</accession>
    <name>A0A1W1I3S6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Manganese transport system, periplasmic binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1429"/>
    <dbReference type="EnsemblBacteria" id="SLM47601">
        <property type="protein sequence ID" value="SLM47601"/>
        <property type="gene ID" value="NSJP_1429"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1429"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="313" mass="34148" checksum="98AA7619AC686193" modified="2017-06-07" version="1">MPAPVLRSNLCALLLALQLLFSVVVPALVSANVPNEGLNVVVTIPVLKDFVEQVGGPRVLVTSLLKGYENEHTYSPKPSDLIAVRKARLLFQVGIGLEVWVSPLVKNAGGSALRVVTTSTGIGLIGDAHAAEDGHAGGESTAEGNPHVWLDPANAVMMVRHITEALIQADPEHAEEYRKNQAAYLTRLDRLQVELTGRVKGLADRQFVAHHPAWPYLARRFRFDIVGTIQLQSGGEPSARHIQELIQTMKRHRVKVVVSEIQLSQKFPDLLAKETGARVVVLTTLPGGLPRTDTYLDMLRYNVLQLVNALEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3X1</accession>
    <name>A0A1W1I3X1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">argG</name>
        <name evidence="10" type="ORF">NSJP_1528</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2 9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1528"/>
    <dbReference type="EnsemblBacteria" id="SLM47700">
        <property type="protein sequence ID" value="SLM47700"/>
        <property type="gene ID" value="NSJP_1528"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1528"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="11"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="403" mass="45209" checksum="8277C06C8C30F9ED" modified="2017-06-07" version="1">MTRPIKKVVLAYSGGLDTSVILKWLQETYEAEVIAFCADLGQGEDLKAVKAKARALGVKNVYVEDLRETFVADYVFPMLRGNAMYEGSYLLGTSIARPLIARRQAEIALKEGAEAVSHGATGKGNDQVRFELTYTALAPRLKVIAPWREWSMRSRRELIEYAERHHIPVTATKAKPYSMDLNLFHVSYEGGILEDPWEAPPDEIFQMTVSPEQAPNRAIEVAIGYEAGNPVAVDGKNMSPARLLAHLNKLGGAHGIGRVDLVENRYVGMKSRGVYETPGGTILHVAHRGLESLTMDREVLHLRDSLIPRYADLIYNGYWFSPEREMIQVAIDEAQRDVTGTARVKLYKGNCILVGRRSKQSLYRLDIATFEEDEVYNQKDAEGFIRLNALRLKIRAQRKKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3X8</accession>
    <name>A0A1W1I3X8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Twin-arginine translocation pathway signal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_1361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1361"/>
    <dbReference type="EnsemblBacteria" id="SLM47533">
        <property type="protein sequence ID" value="SLM47533"/>
        <property type="gene ID" value="NSJP_1361"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1361"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="110"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="439" mass="48650" checksum="22381B4F17728BE5" modified="2017-06-07" version="1">MAMINRRRFLIQTGLAVGSAVLARQAALAMPETVQVPVSAGSNWQSVRAQFPLAPGLIHLAGFFLASHPLPVRQAIERHRQGLDADPIGYWFEHEAKQDAAVLQAAAGYLDVDPTEIALTDSTTMGLGLLYGGLKLGKEQEILTTTHDHYSTETSLNLRAARTGAIVRRIPLYQDLRAVSRDHLVETLVRNVRPRTRIVAVTWVHSSTGLKLPIGEMARALKALNASRAEEDRIIFCVDGVHALGVEDIRLGEVGCDFFIAGTHKWMFGPRGTGLVWGRKDAWPIAQAIIPTFNTEAYDMWMKTIPQRDLPQSIYMTPGGFHSFEHRWALDEAFKFHQALGKARVTQRIYELNQQVKEGLATMPHVTLHTPLSQDVSAGIVCFEVAGLPPQSVVKKLREKGIIGSVTPYATQYVRLAPGLLNQRDEIDKVLAEIRRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I412</accession>
    <name>A0A1W1I412_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Saccharop_dh_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1570"/>
    <dbReference type="EnsemblBacteria" id="SLM47742">
        <property type="protein sequence ID" value="SLM47742"/>
        <property type="gene ID" value="NSJP_1570"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1570"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd12144">
        <property type="entry name" value="SDH_N_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005239">
        <property type="entry name" value="CHP00300"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007545">
        <property type="entry name" value="LOR/SDH_bifunc_enz_cons_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04455">
        <property type="entry name" value="Saccharop_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00300">
        <property type="entry name" value="TIGR00300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharop_dh_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="414" mass="44217" checksum="E0F469FFBAC8C195" modified="2017-06-07" version="1">MAEAQETVVLKGHIIDSLILAKVLDTILMMGGTFDLRDVSIGKTRQEPSLARILVRASSSQLLTDILRAVQPHGAAVERETDCHYEPAPTDGVFPEDFYATTHLPTQVRLEGRWLDVERIEMDLGIVVDPKAGRVRAAPMGDVRRGELVVCGRSGVRVSPLQRPQEHDVFSFMESQVSAERPHGHIIADVASRMKILRDRSRQGLPDSHVLLAGGPAIIHAGGREALTWLIEAGFIQVLFCGNALAAHDMEADLYGTSLGYGLSAGRAVPHGHEHHLRTINRIRAIGGIATAVERGVIKQGIMAACVRQGVQIVMAGTIRDDGPLPGVITDSIRAQAAMRAAIPGVGLALLVASTLHSVATGNLLPAMVPTVCVDVNPAVPTKLADRGSFQAVGLVMDAASFLRELARILGAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I424</accession>
    <name>A0A1W1I424_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47573">
        <property type="protein sequence ID" value="SLM47573"/>
        <property type="gene ID" value="NSJP_1401"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1401"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="224" mass="25156" checksum="0FA94037C1407BDE" modified="2017-06-07" version="1">MSNLHRAPRAWECAIVLLLMVWCITTPHLAWAAEFENPFDVNMNDPAALHEATRTLVEEVKLAARPQTYLLIDLAAKAVVLKARGVELHRLPIMEWSADSQEKMTGIFRLTVRPAVARRKVDPSGTEQEPISLTDMPASYDLLFSPPLALTVVSPAEQAPVRWSVLRMKRWWQWLNSQIRALASRSDTQADPSIALTLAENEAQSLAWSLTDGMPAIIRRTSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I437</accession>
    <name>A0A1W1I437_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Universal stress protein UspA (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1592"/>
    <dbReference type="EnsemblBacteria" id="SLM47764">
        <property type="protein sequence ID" value="SLM47764"/>
        <property type="gene ID" value="NSJP_1592"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1592"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.550">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013580">
        <property type="entry name" value="LI-POR_suB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042298">
        <property type="entry name" value="P-CP_red_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08369">
        <property type="entry name" value="PCP_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="2">
        <location>
            <begin position="460"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="694" mass="75911" checksum="78DE795D34D9D6DB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4B0</accession>
    <name>A0A1W1I4B0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Type-5 uracil-DNA glycosylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_1537</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1537"/>
    <dbReference type="EnsemblBacteria" id="SLM47709">
        <property type="protein sequence ID" value="SLM47709"/>
        <property type="gene ID" value="NSJP_1537"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1537"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033958">
        <property type="term" value="F:DNA-deoxyinosine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10031">
        <property type="entry name" value="UDG-F5_TTUDGB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044147">
        <property type="entry name" value="UdgB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="10">
        <location>
            <begin position="46"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM47709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="230" mass="26183" checksum="17EC6ED02F900A16" modified="2017-06-07" version="1">MRSLTVLNNRIASCTACRRLVDYRQAIARTKRRQFQDWTYWGRPVPGFGDAKARLYVLGLAPAAHGGNRTGRVFTGDRSGDWLYEALHRFGFANQALSQHRSDGLALSDAYIGATVRCAPPDNKPAPDEFDACRTFLREEIRLLRNVQVIVALGKIAFDHYLKTCRQEGFIPPSPLPLFGHGREYLMPWRVTLIGSYHPSQQNTFTGKLTRPMFHAIFRRAKQIIDWHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4H8</accession>
    <name>A0A1W1I4H8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1607"/>
    <dbReference type="EnsemblBacteria" id="SLM47779">
        <property type="protein sequence ID" value="SLM47779"/>
        <property type="gene ID" value="NSJP_1607"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1607"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="113"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="187"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="313"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="366"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="440"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="496"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="690" mass="77081" checksum="78C436C5240E0D81" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4M1</accession>
    <name>A0A1W1I4M1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Radical SAM superfamily protein, Coenzyme PQQ synthesis protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1591</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1591"/>
    <dbReference type="EnsemblBacteria" id="SLM47763">
        <property type="protein sequence ID" value="SLM47763"/>
        <property type="gene ID" value="NSJP_1591"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1591"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013580">
        <property type="entry name" value="LI-POR_suB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042298">
        <property type="entry name" value="P-CP_red_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08369">
        <property type="entry name" value="PCP_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="45"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="461" mass="50850" checksum="A95F6B4B70BC2B5A" modified="2017-06-07" version="1">MGKSLPILNNPALSGALGSFQQQITNVFTPAKQGDGPLDGRTVDDFKPYLVALNLTKRCNLKCDHCYLDATTKAAGGDDELSTEECFRLIDQIAQVNKGCLLVITGGEPLVRPDILDIARYAVQSGFMVVFGTNGMLIDDQMARTLVDIGVMGVGISIDSLDAAKHNGFRGVPGAWEAAVAGIEASKRNGLQFQVHFSAQPMNYQELPAVIEWAHGLGARVLNVFFMVCTGRGEELTDITPAQYEEVLGYLVTCQDNYKGMLVRARCAPHFKRLAYEKDPNSPITKATGYMGGGCLAGTNYARVTPNGELTPCPYMPLSAGNVRSNSFADLWEQSDVFNSFRYPQLKGKCGDCEYTDICGGCRARPYVDHGDWLDEDQWCLYTPKGGEKIKVAFNTPEESEVLWDDASALRLSRIPYFLRAMVKKGVEKHAREHHVTLITVELMEELRKKRFGNDAPVFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4M4</accession>
    <name>A0A1W1I4M4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47891">
        <property type="protein sequence ID" value="SLM47891"/>
        <property type="gene ID" value="NSJP_1719"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1719"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="120" mass="13769" checksum="A399C9551717F7E0" modified="2017-06-07" version="1">METIRPYHRGLYRLPVSYPAMYCVLSTIGEGVIVNLSAVGCTIQTDNPLPHERSVALRLLLPDRHDSLPIELGEVRWVDGNRAGIEFTKMDRTANLRLHSFVWDLMVERIQAIQRERVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Q9</accession>
    <name>A0A1W1I4Q9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0173 metal-dependent hydrolase NSJP_1808</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1808</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0173 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1808"/>
    <dbReference type="EnsemblBacteria" id="SLM47980">
        <property type="protein sequence ID" value="SLM47980"/>
        <property type="gene ID" value="NSJP_1808"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1808"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00457">
        <property type="entry name" value="UPF0173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022877">
        <property type="entry name" value="UPF0173"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012099602" description="UPF0173 metal-dependent hydrolase NSJP_1808" evidence="2">
        <location>
            <begin position="27"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="3">
        <location>
            <begin position="36"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="289" mass="30373" checksum="7CD7B9A1D1CF331D" modified="2017-06-07" version="1">MIGRFAGAIPTTLLIGAVLMAAPVFAASQTTLIWHGHAAFEVRTPSGAVILIDPWLANPVNPLAKDKQDPLEQIAKADYILITHGHFDHVGDAVAIAKKTGARLVANFELGTNLVKLQGFPKDQLGFDTLMNPGGEIRIANGEVLVAMTPAVHSSGMGNPMANEQEPDLVYGGNPGGFVLKIDGGPTLYHSGDTAYFKDMEVIGEQYAPDIALVNIGGHFGMEPAMAARAVASVKAKTAIAHHYGTFPVLTQDTNGFAVALKKRGIRLQKMAPGGSVTFDGKAVVTAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4W1</accession>
    <name>A0A1W1I4W1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48036">
        <property type="protein sequence ID" value="SLM48036"/>
        <property type="gene ID" value="NSJP_1864"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1864"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="42" mass="4404" checksum="EE4DEE8DAF190218" modified="2017-06-07" version="1">MATQINQLGSMMAADVLAWGAAVIGIALTASAVIWVMRLMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4X7</accession>
    <name>A0A1W1I4X7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair protein RadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_1863</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48035">
        <property type="protein sequence ID" value="SLM48035"/>
        <property type="gene ID" value="NSJP_1863"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1863"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="44"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="168" mass="18278" checksum="EE09D5A5FC2D4888" modified="2017-06-07" version="1">MDGSQTPRKSKRPRTSTPTFTPYRVPRYRLTLVCESSDSVMSGPIQASSSAVAILRPCFAGLDREQFLVAGLDAKHGIIGINIVSIGSLTLSIVHPREVFKPLILMNAAAFICAHNHPSTDPTPSPEDRLLTQRLRQGADLLGITLLDHLVLGEPSYFSFADHGWLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Y7</accession>
    <name>A0A1W1I4Y7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1888"/>
    <dbReference type="EnsemblBacteria" id="SLM48060">
        <property type="protein sequence ID" value="SLM48060"/>
        <property type="gene ID" value="NSJP_1888"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1888"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19580">
        <property type="entry name" value="Exo_endo_phos_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="120"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="373" mass="41635" checksum="C20331C23F968751" modified="2017-06-07" version="1">MRLATFNVENLFDRPKIMNLPKWSDGAQVLKDYARLNELVAQDSYSTADKQELINIMGKYPGLNSPQKKDSKYIHLRDIRGDFFKKPKSKPVEIVANGRGDWIGWFELKTEHIKEVATENTARIVHLVNADIIGIVEAEDRMGLTEFNSAAIKKIGGQPYEHVMLIDGNDDRGIDVGIMSRKAFAIDSMRSHVDDKKGSLSIFSRDCPEYLFTLPSGTRLLVLINHFKSKGYGTAASSNTKREDQAKRVREIYDLRRQEGIAHIAIIGDFNDIPTSVPLSHLLQQGSDLKDTSQHPQFHGDGRTGTHGDGAASSKFDYILLSPALWAVVQQAGVERRGVWGGKNGKLWPILPEMKSEKDAASDHAALWVDLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Z3</accession>
    <name>A0A1W1I4Z3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48097">
        <property type="protein sequence ID" value="SLM48097"/>
        <property type="gene ID" value="NSJP_1925"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1925"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="132" mass="14561" checksum="481E2354E181BAE9" modified="2017-06-07" version="1">MEGLRVKTSDTGGYFAIIGPHNWSVSADGQQLTWNGYALTRVSGSGVTYVGVWSGTDGDPMEIAFGDDGTYQWRWVNENESVYGHYVVSGNILTAYEKRGDMTATGNRLTMDTVWGRSSGRQLFPQCRSLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I589</accession>
    <name>A0A1W1I589_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48049">
        <property type="protein sequence ID" value="SLM48049"/>
        <property type="gene ID" value="NSJP_1877"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1877"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="88" mass="9406" checksum="2F8A291E25C96F28" modified="2017-06-07" version="1">MLLILYVLLALSLQPLLLDHVFAAGSSHEHSDQDICAWLDHAASAGLHSIKPPASLLHCLLASPLSVGIAFSIVDLFFEPVRGPPLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5D1</accession>
    <name>A0A1W1I5D1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA topoisomerase 1</fullName>
            <ecNumber evidence="10">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">topA</name>
        <name evidence="12" type="ORF">NSJP_2034</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2034"/>
    <dbReference type="EnsemblBacteria" id="SLM48206">
        <property type="protein sequence ID" value="SLM48206"/>
        <property type="gene ID" value="NSJP_2034"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2034"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="10">
        <location>
            <begin position="168"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM48206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="779" mass="87605" checksum="E5C6D3CDC7F79D32" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5K3</accession>
    <name>A0A1W1I5K3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1987"/>
    <dbReference type="EnsemblBacteria" id="SLM48159">
        <property type="protein sequence ID" value="SLM48159"/>
        <property type="gene ID" value="NSJP_1987"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1987"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021796">
        <property type="entry name" value="DUF3365"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11845">
        <property type="entry name" value="DUF3365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="199" mass="22017" checksum="B4926F1DCE186CF0" modified="2017-06-07" version="1">MDLKGFWLGLAVGTISTCLFGPWVFSAASKDTEVSDGIAPQAVADYIHSIVQADRTFYTNEIVERMQTRGIVSASEHWKETGDLPLPAQFVLETGRIVAQQSSGIRYRLISNWPINKRNGPTTEFERTALSKILVNADRPYTGVTMEGKTRVFQALYADKALSQRCADCHNVHPRSARRDFKSGDVMGGILLSIPLSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5N4</accession>
    <name>A0A1W1I5N4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2128"/>
    <dbReference type="EnsemblBacteria" id="SLM48300">
        <property type="protein sequence ID" value="SLM48300"/>
        <property type="gene ID" value="NSJP_2128"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2128"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="182" mass="18337" checksum="A309CE785636E607" modified="2017-06-07" version="1">MVSSGQSIGVRGSRNAAFVVLMCSVGFLGVGHAAEELPKESVLPLAMANKAVQAAVEACKKDGYKVSVSVVDRAGELRAMGRADGAGPHTIDSSRKKAYTAASVRRPTSELADLIGKVPTLQSLRDMNEHVLILGGGLPVEIGGEVVGGIGVGGAPGAHLDDACAQAGLDAIGASPKIPASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5P4</accession>
    <name>A0A1W1I5P4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48310">
        <property type="protein sequence ID" value="SLM48310"/>
        <property type="gene ID" value="NSJP_2138"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2138"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011986336" evidence="2">
        <location>
            <begin position="30"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="130" mass="13744" checksum="E1DC464630B765BE" modified="2017-06-07" version="1">MIKTKKTILFSILTATVAVTFLAAGTVSAKNSKKSQSYSSAAAAASSMGAVPQTQDAPKAGRHDEKPGPAWKTIGGTVQHIEGNAYTVEDYEGNQVKLYVGQGTKQIKQKKVGDTVRAEITRGNFANSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I614</accession>
    <name>A0A1W1I614_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Polyphosphate kinase</fullName>
            <ecNumber evidence="6 7">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">ppk</name>
        <name evidence="12" type="ORF">NSJP_2209</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6 7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2209"/>
    <dbReference type="EnsemblBacteria" id="SLM48381">
        <property type="protein sequence ID" value="SLM48381"/>
        <property type="gene ID" value="NSJP_2209"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2209"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00347">
        <property type="entry name" value="Polyphosphate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015589">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PP_kinase_N" evidence="9">
        <location>
            <begin position="26"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase" evidence="8">
        <location>
            <begin position="145"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C_1" evidence="11">
        <location>
            <begin position="358"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C" evidence="10">
        <location>
            <begin position="529"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphohistidine intermediate" evidence="6">
        <location>
            <position position="461"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="590"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="618"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM48381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="725" mass="81223" checksum="33613D84988B388A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I617</accession>
    <name>A0A1W1I617_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Purine catabolism protein PucG</fullName>
            <ecNumber evidence="4">2.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pucG</name>
        <name evidence="4" type="ORF">NSJP_2147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2147"/>
    <dbReference type="EnsemblBacteria" id="SLM48319">
        <property type="protein sequence ID" value="SLM48319"/>
        <property type="gene ID" value="NSJP_2147"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2147"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="3">
        <location>
            <begin position="13"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="395" mass="42547" checksum="FF7FE7E6BFA07F10" modified="2017-06-07" version="1">MVTREFIPPRRLLLGPGPSQVHPRVLRAMSAPVIGHLDPAFLAMMNDVQSLLRNTFQTGNRFTIAISGTGSAGMEAAIVNAVEPGETVLVGVNGIFGTRLVEVTERCGGKAIRLEAPWGSAIDPQAVEQVLRRSGPVKAIAMVQAETSTGCWQPLEAIAQLAKQHDALLIVDAVTSLGGIPVDVDAAGIDICYSATQKCLSCPPGLAPFTISERALAAVTRRRTRCQSWYLDMKLVAEYWTEGTRTYHHTAPISMLYALREALRLVEEEGLPARFARHHLNSNALLTGLLELGLPPLAQPGQRLPMLNCVTVPDVIPEAEVRARLLNRYGIEIGGGLGPLKGKVWRIGLMGESSTEAHVLRLLNALEELFIEGGWLTTPGLAVGAASRIYSRANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I671</accession>
    <name>A0A1W1I671_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48494">
        <property type="protein sequence ID" value="SLM48494"/>
        <property type="gene ID" value="NSJP_2322"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2322"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012596659" evidence="1">
        <location>
            <begin position="25"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="286" mass="32631" checksum="017CDDEBD30AB2BA" modified="2017-06-07" version="1">MMRPFRDWSLPFCLLVCWCLVLIAASGAQGTSDHIWRQIAGEAERLGLPVKFLKAVPADFVKFEFDDLQAFAAEYHLGEHRMVLNRTLSFNAAGGTLRPLNRLTSSEMETLYHELFHAYMDYLATDGRGATLTFARKQQQCRYGVVLINPVVQRRTETEERFLSEVESWEALNEAWAVFVGWAVWNQSESAGRTMQSLLKSAKSRSDWLRRLESADREGKLRGYYEPENSEERAVARKRFLAPASRISSEEVQHLMREALGFPDDLTRQAGQMLGSGGFPRFPHSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6A7</accession>
    <name>A0A1W1I6A7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">rpsD</name>
        <name evidence="9" type="ORF">NSJP_2364</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2364"/>
    <dbReference type="EnsemblBacteria" id="SLM48536">
        <property type="protein sequence ID" value="SLM48536"/>
        <property type="gene ID" value="NSJP_2364"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2364"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="8">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="7">
        <location>
            <begin position="98"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="208" mass="23606" checksum="D725BB6EF1352782" modified="2017-06-07" version="1">MAKYRGPVCRLCRREGEKLFLKGSRCMTEKCAIERRSYPPGQHGQGRQRTSDYSLQLREKQKLRRIYGLQERQFRGVFERAERQTGVTGEALLRLLESRLDNVAYRLGFGASRREARQLVSHGHVTVNGRKLNVPGALVRAGDVVAVRERSRNLVTIQAALESVDGRGVPEWLELDKAGFTGTVRALPTKDQITLPVNEQMVVELYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6B4</accession>
    <name>A0A1W1I6B4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48419">
        <property type="protein sequence ID" value="SLM48419"/>
        <property type="gene ID" value="NSJP_2247"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2247"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="219" mass="24326" checksum="82BC9BCB15B6870A" modified="2017-06-07" version="1">MATSTATTAEEIERQLKALTEQRPKLEAQLGAARQALTSEEDRHQTLLAAALIDGTTETNTTVNDAEDAVSVAHRKVRTLVRSLETLDRELVRLEREFVRAKQVLARAALHQEARRHQELGRELDRRLAEVGEILSQWMDSAIRCYQCQADAGRSPGRTPKSRFREAWLSFGSKYGRPVLDGPLIPGGFECQSYSAPRPDPQTVVSAPNVSDVTHGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6D5</accession>
    <name>A0A1W1I6D5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Farnesyl-diphosphate farnesyltransferase</fullName>
            <ecNumber evidence="2">2.5.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.21" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2267"/>
    <dbReference type="EnsemblBacteria" id="SLM48439">
        <property type="protein sequence ID" value="SLM48439"/>
        <property type="gene ID" value="NSJP_2267"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2267"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004310">
        <property type="term" value="F:farnesyl-diphosphate farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="PTHR11626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="348" mass="39443" checksum="35DD4D45BE0A0BB4" modified="2017-06-07" version="1">MATDTTASKHELLRDLLKRVSRLFYTTLAVVPANVRDQVSLAYLFARAADTIADTDLIDRPRRLDYLGQLKAQFISDHVAWIQVKDIREAIGPLQQHEAERVLLERLEDCFRLFQSFAPDDRRRVQRLMTTLTQGMEMDLTAFPGTSAADLTSFKTLDDLDRYTYYVAGCVGEFWTDLMCAHRPALRSWDVRAMSEVGVRFGKGLQLTNVVKDIAHDLQRGRCYVPEALLSKAGLTPRHLLDGNNLPRVRPVLTHLVRTAVEHLDQGWLYTMAIPRQEIRLRLSCMWPILSAGESLKRVLNAPDLLNPAVHVKIPRSKVYQILALTTATGACGYVGTAYWGRLRKQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6D7</accession>
    <name>A0A1W1I6D7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="9">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycogen branching enzyme</fullName>
            <shortName evidence="9">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">glgB</name>
        <name evidence="12" type="ORF">NSJP_2231</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2231"/>
    <dbReference type="EnsemblBacteria" id="SLM48403">
        <property type="protein sequence ID" value="SLM48403"/>
        <property type="gene ID" value="NSJP_2231"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2231"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="11">
        <location>
            <begin position="163"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM48403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="644" mass="74233" checksum="DF4B623CBE0E819C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6J2</accession>
    <name>A0A1W1I6J2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48627">
        <property type="protein sequence ID" value="SLM48627"/>
        <property type="gene ID" value="NSJP_2455"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2455"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="39" mass="4673" checksum="BC0DCFD39B786E38" modified="2017-06-07" version="1">MDAQQKESYTEPVLMAHELLRDITGSKYREKYRDKVNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6K3</accession>
    <name>A0A1W1I6K3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rluB</name>
        <name evidence="6" type="ORF">NSJP_2486</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2486"/>
    <dbReference type="EnsemblBacteria" id="SLM48658">
        <property type="protein sequence ID" value="SLM48658"/>
        <property type="gene ID" value="NSJP_2486"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2486"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="5">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="239"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="278" mass="31014" checksum="954A0CFFC0EE135C" modified="2017-06-07" version="1">MEVRLQKLIAGTGLASRRKSEALISAGRVTVNGKVVTELGTKVDPGRDHVKVDGKHLSAAQPFVYLLLHKPKNVMSTLDDPGGRTTVKDYLHGVSVRVFPVGRLDFDSEGLMLLTNNGDLSQALLHPRYHVPKTYLIKIKGVATDDEIVQLERGVKLEDGMTSPAIVKKIKKAEQNSWLEVTIREGRKHQVRRMLETVGHRVIKLMRVKMGPLALGDLAPGEFRFLTDREANALRELVERRLTSDDGQESPTRPRQRPAKREGWARSSRGKKSRGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6L3</accession>
    <name>A0A1W1I6L3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetoacetate metabolism regulatory protein AtoC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atoC</name>
        <name evidence="9" type="ORF">NSJP_2301</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2301"/>
    <dbReference type="EnsemblBacteria" id="SLM48473">
        <property type="protein sequence ID" value="SLM48473"/>
        <property type="gene ID" value="NSJP_2301"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2301"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="144"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="471" mass="51649" checksum="68A74258F3D8B1AB" modified="2017-06-07" version="1">MKTATIVVVDDDAVARELLAEALKKEGYNVEAFGSGEEAIARGREGSVDLVLTDIRMGAVDGLTVLREFKRTSPDTAVVVLTAFGSLEGAIEAIKQGAYDYLAKPFKKEEIKLVVERSLDHCRLVRENARFREELKGKEDWSPLVGSSPAMLEVYKLVARVSEGKSTVLLQGESGTGKELIARAIHANGPRRENTFVPVNCGALPDALLESEMFGHEKGAFTGAVGTKTGLFESASGGTLFLDEIGELGQALQVKLLRVMQEQEVRRVGGTASIKVDVRIIAATNRDLEQLVKEGKFRDDLFYRLNVVRITLPSLKERQEDIPMLAHHFLQKCGVGATRAVRGFHPDTLTLLQHYRWPGNVRELENAIERAVSLSRGPLLTPDDLPSAIRQAGSEPIQRVESAESPGEAYLTLEEVEKRHLIRVLKEMKGNKVKAAKVLGIDRRTLYRMADRFGVDLGDDGEGGEAAPVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6U9</accession>
    <name>A0A1W1I6U9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane-bound lytic murein transglycosylase C</fullName>
            <ecNumber evidence="4">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mltC</name>
        <name evidence="4" type="ORF">NSJP_2417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase Slt family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48589">
        <property type="protein sequence ID" value="SLM48589"/>
        <property type="gene ID" value="NSJP_2417"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2417"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024570">
        <property type="entry name" value="Murein_transglycosylaseC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11873">
        <property type="entry name" value="Mltc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mltc_N" evidence="3">
        <location>
            <begin position="64"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="249"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="414" mass="46609" checksum="F26A6DA651F30D46" modified="2017-06-07" version="1">MPDRRIRFLISAVLSTALLSCESTDRMVAATEQALASRTGRTVLEVVQSKDPSKAVQRRLDQYAQDPDRLLSDLRAAQHDFQTLYKALNGKVAEKWGPKEVKLPEKKKYVKYTQSYKSRAIVDFDKAEITVETLDAGDARRSLNRAITAALLTPQDPRTVDLFSDKETPVTGEEEPYLLGLVLDQQNKPVRTPEAAESFANYLVEKKAATRTIDQNGTSKQATYVTMKMVANLSQKQAEKYRPYVMRFAEHYTMSPSLVLAIMRTESNFNPYAVSPVPAYGLMQLVPTSGGREAYRRAKGQDVTPTRDYLFDPEHNVELGTAFLNVLMFSQLDDVANQVSREYCVIAAYNTGAGNVFKTFSKNRTTALQQINDLQPAALYDRLRSKLPYQETRNYLEKVTTYRKGFVISSNASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Y3</accession>
    <name>A0A1W1I6Y3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bifunctional uridylyltransferase/uridylyl-removing enzyme</fullName>
            <shortName evidence="7">UTase/UR</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Bifunctional [protein-PII] modification enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Bifunctional nitrogen sensor protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="7">[Protein-PII] uridylyltransferase</fullName>
                <shortName evidence="7">PII uridylyltransferase</shortName>
                <shortName evidence="7">UTase</shortName>
                <ecNumber evidence="7">2.7.7.59</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">[Protein-PII]-UMP uridylyl-removing enzyme</fullName>
                <shortName evidence="7">UR</shortName>
                <ecNumber evidence="7">3.1.4.-</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">glnD</name>
        <name evidence="10" type="ORF">NSJP_2401</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13673"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
            <dbReference type="EC" id="2.7.7.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein-PII]-uridylyl-L-tyrosine + H2O = [protein-PII]-L-tyrosine + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:48600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GlnD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.59" evidence="7"/>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2401"/>
    <dbReference type="EnsemblBacteria" id="SLM48573">
        <property type="protein sequence ID" value="SLM48573"/>
        <property type="gene ID" value="NSJP_2401"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2401"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008882">
        <property type="term" value="F:[glutamate-ammonia-ligase] adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00277">
        <property type="entry name" value="PII_uridylyl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005190">
        <property type="entry name" value="GlnE_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010043">
        <property type="entry name" value="UTase/UR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47320">
        <property type="entry name" value="PTHR47320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03710">
        <property type="entry name" value="GlnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006288">
        <property type="entry name" value="PII_uridyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01693">
        <property type="entry name" value="UTase_glnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="9">
        <location>
            <begin position="461"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="701"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="814"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uridylyltransferase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM48573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="892" mass="99696" checksum="33033159B778C768" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I742</accession>
    <name>A0A1W1I742_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_2647</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2647"/>
    <dbReference type="EnsemblBacteria" id="SLM48814">
        <property type="protein sequence ID" value="SLM48814"/>
        <property type="gene ID" value="NSJP_2647"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2647"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0533">Nickel</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="235" mass="24811" checksum="25E146A779B9FAED" modified="2017-06-07" version="1">MMDPSYLTILGFGFVLGLRHALDADHIAAVSTVLATRPSWRASGLIGFSWGLGHTLVLLLVGTVALALQISIPESVANAAEFAVGLMLIALGGVLALRVFRERWHSHSHDHEGRRHDHVHSHAATSGHGHAHWWSDSVKPLCIGMAHGLAGSAAILIVVVTASRTFLEGLAYIALFGLGSIIGMMLIGLVLSLPVIWSLSFGRHALLVVQGVAGLGSIGLGLSMLVRIATGEHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I746</accession>
    <name>A0A1W1I746_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2461"/>
    <dbReference type="EnsemblBacteria" id="SLM48633">
        <property type="protein sequence ID" value="SLM48633"/>
        <property type="gene ID" value="NSJP_2461"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2461"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="201" mass="22207" checksum="D0A7240B39CFCA2B" modified="2017-06-07" version="1">MKQLFHGIWQWSWFSEEKQLDFNGLFLAIGEHKILVDPPPLTAEATTLIRRQGGVEYIVVTNRDHRREAETCRHEFRCQLWVPHEDAGQMDLQPTRTFKDGELLPGGLWVVRLTDQKSPGESALFIPQGKGILVVGDALIGKPAGAVSLLAAEKYADAGKAREGLRRLLKYAFDALLVGDGVSILTGAKPVVELALKDSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7A6</accession>
    <name>A0A1W1I7A6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48865">
        <property type="protein sequence ID" value="SLM48865"/>
        <property type="gene ID" value="NSJP_2698"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2698"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="98" mass="10984" checksum="7FC149EFA8FB210C" modified="2017-06-07" version="1">MCVHASHAVLILISCMPTRRRTEFCCSFQTYADRSFLRLLLRTLLRALPPSSSVEQEGGIREKGATNGRRRGRLRVLPHGLLPVHPSAIPPPMAFPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7H4</accession>
    <name>A0A1W1I7H4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48935">
        <property type="protein sequence ID" value="SLM48935"/>
        <property type="gene ID" value="NSJP_2768"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2768"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="204" mass="22858" checksum="5938381756FD9C43" modified="2017-06-07" version="1">MSVLFTSRRRPLWIQTAIGILLLAGCSTTSLDMTDKPIQPPAPGWGVVVGSVLVEAEDDPPDSWWNRSFGRNAEGFTYEFQIVRVELTDLEGTSHPYARRYQLDAKPRVERTFVARLPVGTYLVKTFRHEGLSAIGGDLDVRFSVEAGRIQYLGRLVLTVPRRVSFGAPYTFRIVDARDSTLTKLQQRHPVLAGEVVNSPMQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7P7</accession>
    <name>A0A1W1I7P7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49037">
        <property type="protein sequence ID" value="SLM49037"/>
        <property type="gene ID" value="NSJP_2870"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2870"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="121" mass="12666" checksum="512D19293CDDB3FF" modified="2017-06-07" version="1">MGKHFATGLVLFGLMTMVAGCTSYYRVTDPASGKTYYTTEMKDAGRGGAVKIKDAKSGSMVTLQSSEVKEISEEEYEAALKAPSMKATAPMPSAEKATAPMPSAEKATAPMPPAEPQPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Q8</accession>
    <name>A0A1W1I7Q8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49047">
        <property type="protein sequence ID" value="SLM49047"/>
        <property type="gene ID" value="NSJP_2880"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2880"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1362" mass="145719" checksum="BF2A457522C74220" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7R8</accession>
    <name>A0A1W1I7R8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49056">
        <property type="protein sequence ID" value="SLM49056"/>
        <property type="gene ID" value="NSJP_2889"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2889"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl" evidence="2">
        <location>
            <begin position="67"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="241" mass="26426" checksum="92997E0449CF8588" modified="2017-06-07" version="1">MNHRHDISRDQAWPQSGLAVLWVLALCVGVSILPGMVTESVADDSLRSKKWEILLSPQYTLTKNLGFTGGTTAKIDDTWGFGLQIGYNFNEHWNLGGFFSWSQPDYQAVVQPAPGNSGPARNISGNLQMNTFGGVLTYNVLSGPLTPYVEGSLAGTYINTDIADGPPVSGCYWDPWFGYICGTTQPTKSGTFMTYGVGGGLRWDINRYFLVRGGVRQQWIDLSNTGIPGFTTFKLDIGFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7W3</accession>
    <name>A0A1W1I7W3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2923"/>
    <dbReference type="EnsemblBacteria" id="SLM49090">
        <property type="protein sequence ID" value="SLM49090"/>
        <property type="gene ID" value="NSJP_2923"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2923"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010328">
        <property type="entry name" value="DUF928"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06051">
        <property type="entry name" value="DUF928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="264" mass="28883" checksum="B6692D03753391BB" modified="2017-06-07" version="1">MNATHPHAFLRTRAARSSGTVLMGVMLATISVIGSDMPPGFAEQVTTQANGTSRDQIPLYQPPKKFTPRARVGGELRGTEGMDPEVQALVPDHVGFTSSQTPVLNWYLSKPTPHEVRFTLIDNQSVRPVYEAPIPTPKQPGIFSIAIKDLGLALDPNIQYRWYVSVVRDPSSPSKDIVGGGVIERCEMSDCLITFDAKITCSVQTVTDNARAGFWYDAMGCLCTLIDANPTDASLRRLRAGLLKQVGLNGVAEWDLRSVQTQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I806</accession>
    <name>A0A1W1I806_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48943">
        <property type="protein sequence ID" value="SLM48943"/>
        <property type="gene ID" value="NSJP_2776"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2776"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="65" mass="7581" checksum="D78EC5C7A646E809" modified="2017-06-07" version="1">MTQYHWSEVKPTKAGWYWFRGQIHEADPFIVLVDDVGQFQWPDGGYQEVTLAKGEWAGPIEEPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I823</accession>
    <name>A0A1W1I823_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49009">
        <property type="protein sequence ID" value="SLM49009"/>
        <property type="gene ID" value="NSJP_2842"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2842"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="240" mass="26935" checksum="C561C10CFBF5EB55" modified="2017-06-07" version="1">MRATVESTTLPLLDRPGDEYAAETKHGASGDWSLALRYAQVPFYPDDKLLLLHGHALVFRLGLHIATERVLGGEPVLYVDGANTFDPFAVGRLARARRRQPRQVLAGIHVARAFSSHQIERLISDCLGAALDRYHSRIAMLAGLFETFYDQAVSDHSAEKLFGRMMNAIIRLTRQGYTIVCLCPSVPILTQAGRQRFDQLRVHADRVLRVQEGQGVVRLHDDGLNDGRSWEIPRTLLTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I842</accession>
    <name>A0A1W1I842_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49091">
        <property type="protein sequence ID" value="SLM49091"/>
        <property type="gene ID" value="NSJP_2924"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2924"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="101" mass="10665" checksum="56E3D6158FD3852A" modified="2017-06-07" version="1">MPLAWVVTCSAKPGGMSEPITLIVASMTPISTVPEDLAARVRRKAWGCVAFMAAALTLDVRLKLQKTILSASTVDDVTLSAGCRDGPQVPLSHEMKADLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8H2</accession>
    <name>A0A1W1I8H2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2926"/>
    <dbReference type="EnsemblBacteria" id="SLM49093">
        <property type="protein sequence ID" value="SLM49093"/>
        <property type="gene ID" value="NSJP_2926"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2926"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ANAPC5" evidence="3">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="ANAPC5" evidence="3">
        <location>
            <begin position="309"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="546"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="815" mass="90441" checksum="A04360477F23ABB9" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8K3</accession>
    <name>A0A1W1I8K3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">recA</name>
        <name evidence="12" type="ORF">NSJP_2956</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the RecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2956"/>
    <dbReference type="EnsemblBacteria" id="SLM49123">
        <property type="protein sequence ID" value="SLM49123"/>
        <property type="gene ID" value="NSJP_2956"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2956"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="10">
        <location>
            <begin position="38"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="11">
        <location>
            <begin position="202"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM49123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="363" mass="39226" checksum="EFDEBF49C7005CC8" modified="2017-06-07" version="1">MAEKDDKKRALDLALSQIEKQYGKGAIMKLGDAEANADIPAISTGSLGLDIALGVGGFPRGRVIEIFGPEASGKTTLTLHAIAEVQKTGGVAAFIDAEHALDLTYAKKLGVQADDLLVSQPDTGEQALEIAETLVRSGAIDLIVVDSVAALTPRAEIEGEMGDAHMGLQARLMSQALRKLTAAIAKSQTTVIFINQIRMKLGVMFGNPETTTGGNALKFYSSVRLDIRRIESLKEGQDVVGSRVRVKVVKNKMAPPFKQAEFDILFAQGISKSGELVDLGVDRKVLEKSGAWYSYRAERLGQGRDAVRDFLQTNQPLAREIEGKLRDIAALPGRGTEKAAAPAKEERRTEEKREERRPHKVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Z3</accession>
    <name>A0A1W1I8Z3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kelch repeat type 1-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3317"/>
    <dbReference type="EnsemblBacteria" id="SLM49484">
        <property type="protein sequence ID" value="SLM49484"/>
        <property type="gene ID" value="NSJP_3317"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3317"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="SSF117281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="327" mass="34771" checksum="1220A8B38B153C0C" modified="2017-06-07" version="1">MLHGLLLVCLLPQPSGAEPTKPDPGQGAWRTARPASLQRTEAVAVTVNGKIYVVGGFEPPGVGTATKLAITPALEEYDPASDRWTARASMPMGLHHTGIGAVGGLVYVIGGYKQSGLSIWQPVASVYAYDPAADKWTERAPMPTARGALAVAELDGMLYAIGGFGEKGNSPAVEIYDPAHDRWMPRTPLPTPRDHLAVVALNRKIYAIGGRLNGDYQRNLAVTEVYDPAVDRWESAPPLPTARSGIAAVSLGNRLYVFGGEGPEGTFRENEAYDPARHEWQRMAPMPTGRHGLGAASLQGGIHVIDGGPTPGGSFSNLHEIFTPPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I914</accession>
    <name>A0A1W1I914_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3126"/>
    <dbReference type="EnsemblBacteria" id="SLM49293">
        <property type="protein sequence ID" value="SLM49293"/>
        <property type="gene ID" value="NSJP_3126"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3126"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010869">
        <property type="entry name" value="DUF1501"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07394">
        <property type="entry name" value="DUF1501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="467" mass="49749" checksum="3E3364B6352C4750" modified="2017-06-07" version="1">MPNRPRLKRDIPEPPPADRDEKERTCACCGESNEILSRRAFLRRVAGTAAAATFLSLFPSVLLKHRQAWAAGNAGKTLVVIFQRGGNDGLNTIVPYSDPEYYVMRPRATSGGIGILPPGTGDGAGLDLPGTGFAMHPSLQPLLSLYTNGALAVVTRAGFAGSTQSHFTDQDTIERGVFTMKNGWLNRYLQAVSPSGSPAMRAAGFGNDLADSLRGEVLVPAVNNLRSLSFARLNSTKGLLEDNLRTMYMQDPALTTTNPFRSLVHQLGPDMLNRIAAIEAIGPAAPQNGAAYPNTSFGTQLRDLAHLIRAGMGLEIATVDIGGWDTHEDQGAGGSFARNQGARLAEMAGGIRAFHDDLGPLMNNVVVMTCTEFGRTVRQNASNGTDHAKGTVWFLVGGGIKGGLYHGTAGWPAALLPANLDQGRYIAPTVEFRDIFSDVLTRHFGTTPSELAAILPGHVHKPVGLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I991</accession>
    <name>A0A1W1I991_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">trpB</name>
        <name evidence="13" type="ORF">NSJP_3206</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3206"/>
    <dbReference type="EnsemblBacteria" id="SLM49373">
        <property type="protein sequence ID" value="SLM49373"/>
        <property type="gene ID" value="NSJP_3206"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3206"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="61"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM49373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="404" mass="43969" checksum="BCC36E8F32D9F3BB" modified="2017-06-07" version="1">MPKKIRKSSAIPDARGRYGIYGGRYVPETLMPALLELEQEYAKARNDTRFQEEFAYYLKQYVGRPTQLYFAQRLTKHLGGAKIYLKREDLCHTGAHKINNAIGQGLLAKRMKKPRIIAETGAGQHGVATATVAAMFGLQCEIYMGTEDMQRQALNVFRMRLLGSTVTGVDAGSRTLKDAISEAMRDWTTNVLTTHYVLGSALGAHPYPMMVRDFQSIIGREARKQIVAAEGRLPDCLIACVGGGSNSIGLFHAFLRDKTVKMIGVEAAGLGVASGKHAARFSGGRLGVLQGTMTYLLQDDDGQINLTHSVSAGLDYAAVGPEHSYLRESGRATYTSATDDEALAAFDLLAREEGIVPALESAHAIAHTVKLAPTMKRNQILLVNLSGRGDKDVQQVARMRGIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9A4</accession>
    <name>A0A1W1I9A4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Ferredoxin-NADP(+) reductase</fullName>
            <ecNumber evidence="2">1.18.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.18.1.2" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3427"/>
    <dbReference type="EnsemblBacteria" id="SLM49594">
        <property type="protein sequence ID" value="SLM49594"/>
        <property type="gene ID" value="NSJP_3427"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3427"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="448" mass="48739" checksum="D14FBCFB666F287A" modified="2017-06-07" version="1">MSAKAAHVIIVAGAGPAGMAVAGTLAKAGHEVIILNRDIKFGGLAEYGIFPSKLKLRGGLKKQYWELLEQQNVHYFGNVSIGKGKDLSVEDLRNLGASAVVYSIGAQGTKAIGVEGDTAAGVFHAKDVVYHFNRLPGFGDRPFDVGRHVAVIGAGDVMVDIAHWLTRYKKVERVTAIVRRGPAERKYNPKEIRAVCSNMDVDDITKEVERIKDRLIAVGQKPDEILKGLLGEFTKCEPKNSDAKMSFKFLASPKRILVDGNNRVRGLEMEDNKLEPKGEDTAAVGLKQFYEFPCDSVVFAVGDKVDETVGLPYKSGVFVTNPVKTNNDPDDALFQAYDDSTGKVLDGVFLAGWARKASEGLVGVAKRDGDWCAEVVGRYLLTKPAPGNPKSVVEKLQATLRERKSHPVGVKGLRVLEAAEKAQQAKDDCIGEFKFATNQDMIRLVEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9D9</accession>
    <name>A0A1W1I9D9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49616">
        <property type="protein sequence ID" value="SLM49616"/>
        <property type="gene ID" value="NSJP_3449"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3449"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="221" mass="23081" checksum="F03039B248EAD7D8" modified="2017-06-07" version="1">MRMTQQSAMKRIMFSVILLLSLVGPWTGADAALVTYSFTGGVSQVNGGLMPTVNLMSPVSGTFQFDNSPATGGNYPGVVTNMTLAIGGYTSNYMAGANTVQVAKGIDLGGTFGDRWRLVTAATGLPINGYSPMRFDLNLDREGSLFANTDMQNPPSLSSLTGSRWRLIFENADGNLVRIQGSLSSLTAVPLPAAMILFGAGLISLVGLGAGGLRSFKGTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9F4</accession>
    <name>A0A1W1I9F4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 1 (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3453"/>
    <dbReference type="EnsemblBacteria" id="SLM49620">
        <property type="protein sequence ID" value="SLM49620"/>
        <property type="gene ID" value="NSJP_3453"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3453"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="592"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1401" mass="155843" checksum="E2D9E063901A733D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9K0</accession>
    <name>A0A1W1I9K0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49601">
        <property type="protein sequence ID" value="SLM49601"/>
        <property type="gene ID" value="NSJP_3434"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3434"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="123" mass="13777" checksum="D47CDBC3A5482153" modified="2017-06-07" version="1">MPTVGTSSSGQFSCATTDQRTLRDLRIKRKGQPVFVLGHLVDRKGQEAVFEVFNDRLAVVKFSDGTMIGYDPFELLLPTDIDQEGTAYFEIRTCRLCEQLFPLTGDECDAPEEPTSCFECRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9M2</accession>
    <name>A0A1W1I9M2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Sulfurtransferase TusA</fullName>
            <ecNumber evidence="3">2.8.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3581"/>
    <dbReference type="EnsemblBacteria" id="SLM49748">
        <property type="protein sequence ID" value="SLM49748"/>
        <property type="gene ID" value="NSJP_3581"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3581"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="80" mass="9017" checksum="60C6FA9017FF0B58" modified="2017-06-07" version="1">MTVRPDAELDLRGVSCPFNFVKTKLKLDTMEEGEVLAILLDDGEPIRNVPQSLRNEGHTIVSQEQTEQMHRVVIRKGGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9M3</accession>
    <name>A0A1W1I9M3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49714">
        <property type="protein sequence ID" value="SLM49714"/>
        <property type="gene ID" value="NSJP_3547"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3547"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="67" mass="7599" checksum="6A949DC526322D40" modified="2017-06-07" version="1">MTWEELPLQEIGLTNRGWYPTAVGDETFSARVIDCGRIGYGIRLRGPLYCGVSMSARVSFGRWMITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9P9</accession>
    <name>A0A1W1I9P9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49599">
        <property type="protein sequence ID" value="SLM49599"/>
        <property type="gene ID" value="NSJP_3432"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3432"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="66" mass="6960" checksum="968F97B2019D1CA5" modified="2017-06-07" version="1">MAILGTLILISSLIYLWTPAGQPQRRTIKAVGTSTLGHGSPPATIPQHSTATGEDGMMTQKTRGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9S2</accession>
    <name>A0A1W1I9S2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Cytochrome c biogenesis protein CcsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3579</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3579"/>
    <dbReference type="EnsemblBacteria" id="SLM49746">
        <property type="protein sequence ID" value="SLM49746"/>
        <property type="gene ID" value="NSJP_3579"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3579"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="6">
        <location>
            <begin position="65"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="266" mass="29009" checksum="AE083D7FCCE16935" modified="2017-06-07" version="1">MAAVFFMVTMALYFTATMVFLALLLRRSEALSTVALSITATGFVTHTLALVARMVGTTASPPSFQEALSFFSWMLILVFLVVEFRHRLHVLGSFILPLALVSLVSAAALPETAPTLQPVFRTLWVHVTLSMLGTVGFAVAFVAGVMYLIQDGLLKSKRFNVLYSKLPALDFLDELNQQSIVFGFPLLTLGIVTGAISAEFARGAYVNWNPEQTWAIVTWLFYFVVLVGRLTVGWRAKRAAYLTIIGFACVILTLVGVAIKSSGAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9V5</accession>
    <name>A0A1W1I9V5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3608"/>
    <dbReference type="EnsemblBacteria" id="SLM49775">
        <property type="protein sequence ID" value="SLM49775"/>
        <property type="gene ID" value="NSJP_3608"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3608"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="73"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="144" mass="15472" checksum="E1FC227585A5D8CA" modified="2017-06-07" version="1">MSTVAKIMKKPVKSVGPTTSVVSAAKTMKSSRIGALLVKKGKQFVGIVTDTDVVRRAVSSGKPLGKLTVQKIMTSPVCTLEGSQSVDDAQDMMGDLGVRHLAVTQNGNIVGIVSVRDLLMHYKRYAQSKIPQVEQYSEPKIGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Y2</accession>
    <name>A0A1W1I9Y2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0060 membrane protein NSJP_3691</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0060 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49858">
        <property type="protein sequence ID" value="SLM49858"/>
        <property type="gene ID" value="NSJP_3691"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3691"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00010">
        <property type="entry name" value="UPF0060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003844">
        <property type="entry name" value="UPF0060"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36116">
        <property type="entry name" value="PTHR36116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02694">
        <property type="entry name" value="UPF0060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="108" mass="12284" checksum="815AAC51F3D260AB" modified="2017-06-07" version="1">MLIMQSIALFLLAGLFEIGGGYLIWHWWRNGGHWSFGLLGAAVLFLYGIVPTYQPAHFGRVYAAYGGWFVVLSLLWAWQVERIAPDRFDLIGGFVCLMGVAVIMYWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Z3</accession>
    <name>A0A1W1I9Z3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">cobD</name>
        <name evidence="11" type="ORF">NSJP_3532</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3532"/>
    <dbReference type="EnsemblBacteria" id="SLM49699">
        <property type="protein sequence ID" value="SLM49699"/>
        <property type="gene ID" value="NSJP_3532"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3532"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM49699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="316" mass="34433" checksum="3CD45F7034507BBF" modified="2017-06-07" version="1">MPSDLLLAGLLDALVGDPPWLPHPVRGMGRLIGAFETTIRPWCKARGSLSLAGVLLACALPSLTFGLAWTMITAATVVHEWLGRSLEIWMAFTTLAWRDLTDHVIRVSNPLKIRSWQEARAALSRIVGRDTDHLSEPEIVRATVETVAESASDGIIAPLFYLILGGAPLALAYKAVSTLDSLIGHRDERYREFGWASARLDDLVNWLPARITAALIILATAVVFRRPGPVRRSVGVLWRDGHKHPSPNSGRPEAAMAGALGIQLGGTNYYDGIPQTRPFLGTAIEPLAVRHITQAKYVMTVAYLFGFAAACGFLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Z4</accession>
    <name>A0A1W1I9Z4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3659</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3659"/>
    <dbReference type="EnsemblBacteria" id="SLM49826">
        <property type="protein sequence ID" value="SLM49826"/>
        <property type="gene ID" value="NSJP_3659"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3659"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="153" mass="17258" checksum="1356CC6DAC077B93" modified="2017-06-07" version="1">MLTRLELRIPPVALVFLFAALMWVVSIYSTFTFALPWRSALAALVGIAGSAIMLSGVLSFRRAKTTVNPLTPEAATTMVTSGIYRFTRNPMYLGFLLVLTGWAIYLSNLPAFALLPLFVWYLNRFQIVPEERVLGVKFPQTFTAYTTSVRRWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA19</accession>
    <name>A0A1W1IA19_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-allo-threonine aldolase</fullName>
            <ecNumber evidence="6">4.1.2.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ltaA</name>
        <name evidence="6" type="ORF">NSJP_3731</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.49" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3731"/>
    <dbReference type="EnsemblBacteria" id="SLM49898">
        <property type="protein sequence ID" value="SLM49898"/>
        <property type="gene ID" value="NSJP_3731"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3731"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="PTHR48097:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="5">
        <location>
            <begin position="9"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="348" mass="36981" checksum="3838C0AFF56F56FA" modified="2017-06-07" version="1">MHSGMTLIDLRSDTVTKPTTAMRKAMAQADVGDDVYGEDPTVNKLQDAVAALLGKKAALFVPSGTMANQLAIRVHTQPGQEVIAESKAHIVRYEQGAAAALSGVQLHCIPGDRGLVGADLVEAAIRPSDPHTVRTALICLENTHNGGGGTIYPLSTIERIRAVAVDRRIPMHLDGARLFNAVTATTLPAASYAQHFETVSLCLSKGLGAPAGSLLASNDLALIERARRFRRMYGGAMRQAGVLAAAGLYALEHHVARLKTDHDNAKRLARRLQHIPAITISPQHVETNIIVFDVPGHRLAPAALVAALKQEGVLINAVGGTSFRAVTHLDVSTEAIDQAADVFARVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAN2</accession>
    <name>A0A1W1IAN2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3656"/>
    <dbReference type="EnsemblBacteria" id="SLM49823">
        <property type="protein sequence ID" value="SLM49823"/>
        <property type="gene ID" value="NSJP_3656"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3656"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014845">
        <property type="entry name" value="GYD/TTHA1554"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08734">
        <property type="entry name" value="GYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="97" mass="10790" checksum="38F7BA4A4CD91A94" modified="2017-06-07" version="1">MPTYIIQSQWTDQGIRNVKDAAKRLDLGRKTLKEMGGDIKAFYLTTGSYDMLAIVDVPDDATLAKHLLWLGSQGNLRTQTVKAFTEDEFRGIIGGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAT3</accession>
    <name>A0A1W1IAT3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-beta-D-heptose 7-phosphate kinase, domain I of bifunctional protein HldE</fullName>
            <ecNumber evidence="2">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfaEa</name>
        <name evidence="2" type="ORF">NSJP_3981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3981"/>
    <dbReference type="EnsemblBacteria" id="SLM50148">
        <property type="protein sequence ID" value="SLM50148"/>
        <property type="gene ID" value="NSJP_3981"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3981"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01172">
        <property type="entry name" value="RfaE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011913">
        <property type="entry name" value="RfaE_dom_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02198">
        <property type="entry name" value="rfaE_dom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="36"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="345" mass="37206" checksum="A96318FD7F3305CB" modified="2017-06-07" version="1">MSRSPRSSTAKSEASGRVEGISNGGLRRYIQRFPQASVLVIGDLILDHYIWGRVSRISPEAPVPVVHVESESMRLGGAANVFNNILALGGKADLCGAIGQDETGRMLLKELGTKRSGRGGVVIDHDRPTTRKSRVIAHNQQVVRYDLERRGELKPVLQKRILRYVESRLRELSCLVVSDYCKGVVTATLMSELTRLAALRQVPIIVDPKVEHFSYYKGVTVITPNHLEATQAAGLHGDDDQVIQEAGSIIRQRLGCQSVLVTRGERGMSLFEADGVSWHIPTRARQVYDVTGAGDTVVGTMALALSTGASMREAASLANQAAGVVVGMVGTATVTAKQLTEALEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAU4</accession>
    <name>A0A1W1IAU4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase_M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_3938</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50105">
        <property type="protein sequence ID" value="SLM50105"/>
        <property type="gene ID" value="NSJP_3938"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3938"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M48" evidence="7">
        <location>
            <begin position="108"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM50105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="364" mass="40947" checksum="2D81C5C385441BD1" modified="2017-06-07" version="1">MPYLRPSVPEPRRILPSRTVRRPGLITIGLVLLCAGLLSGGCVTELTPEERQAREELLEKLRPWRQEQRNRLNFLSLSLQDGPGRPAILPVILYAGQSGDRIDAGCTGDVIALFEGLVRFLSQDDELAFVIAHEMAHCLHGRGSWVRSGVRQSYSSYSLSEETQADAHALTYMYQAGFDVDIGVETLVRLTTEVPKSLTGSYFSLHPHVLERIARAKVHAAALHGGLHPLTNQPLPPPVQKVTFAMTSWVDLNRVTKESRWVQRFDDEMRAFVGVRLNEVQASKLHLRFVEEQGDRSAAERARKESDALVNKLRHEIEDKQIEVLSQTSLPFHRTILQVTREGIQGDPNARLAQLLDHKYLPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAW9</accession>
    <name>A0A1W1IAW9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Sugar transporter of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_3894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3894"/>
    <dbReference type="EnsemblBacteria" id="SLM50061">
        <property type="protein sequence ID" value="SLM50061"/>
        <property type="gene ID" value="NSJP_3894"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3894"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="15"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM50061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="433" mass="45803" checksum="22850E44E0B499DA" modified="2017-06-07" version="1">MTRHSITSTPIRWLILGLLFLTSVVTYIDRVNISVAARHMMPAFGLTDQEMGWVFSAFVAGYALFQIPGGWLADRWGARAVLTGALLWWSVCSAFTALAATSVLADVAGILGALIIVRFLLGVGEAVALPCFNRAVANWMPADARGIGIGIAIGGIGLGSAVTPPIAAWVMVNWGWHIVFYLSAAVGLAMALIWWTLARNDPDEHPWVKNLSTNGPAEQPLHPQPQSDDAVPWRRLARTPTVWWLVLSYTCLGYVAYLYLSWFYLYLVNVRGFDVLRGGLHGAAPFLAMLIGCPAGGWVTDRLAARYGVTAGRGIAGIGGMAAAGCAIIAGAFAVSPLIAIASLSVGAGCLYFTVGAYWASTTDLSKAHAGTLSGLMNTGANVGGAISPVLTPWIAGHWGWPISLAAAGFVAFTGAALWLRIKPGDGLRHVQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAY9</accession>
    <name>A0A1W1IAY9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3914</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3914"/>
    <dbReference type="EnsemblBacteria" id="SLM50081">
        <property type="protein sequence ID" value="SLM50081"/>
        <property type="gene ID" value="NSJP_3914"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3914"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032623">
        <property type="entry name" value="FecR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16220">
        <property type="entry name" value="DUF4880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4880" evidence="3">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="118"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="332" mass="36896" checksum="A6F9B4E0362F38E3" modified="2017-06-07" version="1">MDGAVFDMIDPQLPQRHLQDQAVAWLVRLQSEEATDADRAGFAAWLALSDSHRNAYSEAEMFVGKLRRLALEAWDEQLFKTPSRSRVWARWWVPAVAACMALLFLVFFRPASTPLSPDVLKTAKGEHRRFQLEDGSSVLLNSNTTVRVAFTGQHRGMELEAGEAFFVVAKDSKRPFEVHAGLGTTRAVGTEFNVRLRESTATVTVVEGVVRVSPSPRSGGGTVADSSVEVSHNEAVSYSGSDGMGSLRRSDPVTSLAWQRGQMVFNKRPLAEVIDELNQQWDRRVFVAGPRLRQLPVNGVFDIHDPDAVVRAVERTFHVRSLSLPLNILVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB56</accession>
    <name>A0A1W1IB56_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">7,8-diamino-pelargonic acid aminotransferase</fullName>
            <shortName evidence="4">DAPA AT</shortName>
            <shortName evidence="4">DAPA aminotransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">7,8-diaminononanoate synthase</fullName>
            <shortName evidence="4">DANS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diaminopelargonic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">bioA</name>
        <name evidence="6" type="ORF">NSJP_3984</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate</text>
            <dbReference type="Rhea" id="RHEA:16861"/>
            <dbReference type="ChEBI" id="CHEBI:16490"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="EC" id="2.6.1.62"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.62" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3984"/>
    <dbReference type="EnsemblBacteria" id="SLM50151">
        <property type="protein sequence ID" value="SLM50151"/>
        <property type="gene ID" value="NSJP_3984"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3984"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00834">
        <property type="entry name" value="BioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005815">
        <property type="entry name" value="BioA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00508">
        <property type="entry name" value="bioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="119"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="325"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM" evidence="4">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM50151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="459" mass="51549" checksum="CD4E369F4E9F272E" modified="2017-06-07" version="1">MQKRVTTTQLGQWDRTYLWHPFTQMQEWETEEPLIIERGTGVYLIDRAGRKYLDGTSSIWVNLHGHRHRILDRALRDQLNRIAHSTLLGLSNTPAILLARELIRLAPKGLRRVFYSDDGSTAVEAALKMAVQYWQQHDPAAGPKHLFLHLKLAYHGDTIGAVSVGNIEAFHSRFKPLLFPTLEADPPYCYRCPLNLRFPSCKIACLDPIEQIMRARGHELAGVIIEPLVQAAAGMITAPPGYLKRLRELCTRYNILLIADEVATGFGRTGKMFACHHEDVTPDLMAISKGITGGYMPLAATLATENIYAAFRGTFEELKTFFHGHSYTGNQLGCAVALANLAVFRKERTLVRLRPKIAVMTRLLNSMTSLRHVGDIRQQGFMAGIELVKNKQSREPYPFEMRIGHRVAQEARGRGLLLRPLGNVMVLMPPLATTVPALTRMVTLLRESIQQVTDSRSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB64</accession>
    <name>A0A1W1IB64_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">recO</name>
        <name evidence="9" type="ORF">NSJP_4079</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the RecO family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4079"/>
    <dbReference type="EnsemblBacteria" id="SLM50246">
        <property type="protein sequence ID" value="SLM50246"/>
        <property type="gene ID" value="NSJP_4079"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4079"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM50246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="250" mass="27139" checksum="114FD23E16D9C0FD" modified="2017-06-07" version="1">MPLIKTAAVTLRSRKWGEADRIVTFYTRAAGKVRGVARGARRPKSRLGATLEPLTICELNLFEKSGDSLYRVSQADMVEPFVCFREDLTLMAAAARMANVVTAITPDGDPDPQLFETLEQGLYSLAVSEDPALTALLFQIRLLGLTGFRPQTDHCSACGRGRTIPESQFSPVSGGLVCAACATRQQFHCVPLSRGSLAFLQQALRFAPAVITRLKASGQVRSEVEEAIEGYVTVVVGKRLPPVDFLSQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB70</accession>
    <name>A0A1W1IB70_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rmlC</name>
        <name evidence="4" type="ORF">NSJP_4058</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4058"/>
    <dbReference type="EnsemblBacteria" id="SLM50225">
        <property type="protein sequence ID" value="SLM50225"/>
        <property type="gene ID" value="NSJP_4058"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4058"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="176" mass="20318" checksum="367BACB981C38D36" modified="2017-06-07" version="1">MIFHETILKGAFIVEPERKEDERGFFARTWSTEEYSKHGLNPKISQCSVSYNSRKGTLRGMHYQVPPHEEVKLVRCTRGAIFDVVIDLRPGSSTYTRHTSVVLTEANGLLLYIPEGVAHGYQTLEDDSEVFYQISETFHPESARGVRWDDPCFDIPWPDADRIILPRDRQYPLFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB73</accession>
    <name>A0A1W1IB73_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_4073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50240">
        <property type="protein sequence ID" value="SLM50240"/>
        <property type="gene ID" value="NSJP_4073"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4073"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="57" mass="6383" checksum="E1BB32AD5C8C17A9" modified="2017-06-07" version="1">MDADSTTMPGPARWSASVSELPGAGDSLMCEEAFEEPYNIMPMLDNRMISVNLRKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBE2</accession>
    <name>A0A1W1IBE2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyltransf_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4143"/>
    <dbReference type="EnsemblBacteria" id="SLM50310">
        <property type="protein sequence ID" value="SLM50310"/>
        <property type="gene ID" value="NSJP_4143"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4143"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="161"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="343" mass="38579" checksum="753259A23042CBD7" modified="2017-06-07" version="1">MTPRLSVLGPDDEAAYETFLLGVEESLLYSSLRYKVFLQALLRCEAQYWIAWKDELISGVLPIMWRDGPYGKVINSLPYYGSNGGVLATDQDVAFALTAKYDELVSKPDVAAATWICHPFHAPSVTPAHTVIDERIAQWTSLLWEGHDPESALLGAIDGSARRNIRKAESSGVTVRIDNDQLSFIETVHTENMAEISGKAKSHEFFSKVRTHFNAGTDYRIYVAEQNGILISGLLLFYFNRTVEYFTPVTVSKNRESQPMALILAKAMVDAARQGFLRWNWGGTWLSQDGVLRFKRKWGAKDASYRYFTQLNGPDILKRSKSEILSAYPDFFVVPFHSLTAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZS4</accession>
    <name>A0A1W1HZS4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46245">
        <property type="protein sequence ID" value="SLM46245"/>
        <property type="gene ID" value="NSJP_0073"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0073"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="153" mass="16088" checksum="AC6A3A83290B8632" modified="2017-06-07" version="1">MIDRECVPYYNGFMQDCHELPSHRSLCAAATCFLLLCVAGGGPAWAQTVSGVRGFDGGVAPLFSLVGPGSLYIDNQGTQGYMYNPGNNFQSFSFRNPTTGQAWSGAVMTLGPQLSIGLIQGANQVGSPIVLPSPPRGTAPLPPIESTLLDEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZW8</accession>
    <name>A0A1W1HZW8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46298">
        <property type="protein sequence ID" value="SLM46298"/>
        <property type="gene ID" value="NSJP_0126"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0126"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="29" mass="3411" checksum="C3A098D54ED9FE2D" modified="2017-06-07" version="1">MQHHTLRHRITPKSLALKEKISLSLYHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZY8</accession>
    <name>A0A1W1HZY8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NSJP_0139</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0139"/>
    <dbReference type="EnsemblBacteria" id="SLM46311">
        <property type="protein sequence ID" value="SLM46311"/>
        <property type="gene ID" value="NSJP_0139"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0139"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM46311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="623" mass="68367" checksum="9D475479902A1CA8" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I067</accession>
    <name>A0A1W1I067_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46372">
        <property type="protein sequence ID" value="SLM46372"/>
        <property type="gene ID" value="NSJP_0200"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0200"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="2">
        <location>
            <begin position="25"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="132" mass="14374" checksum="6C708930C9F8D973" modified="2017-06-07" version="1">MLPLSFPAGAVPMSPSGSEEAGRMERRRHRRVPAQINGLLCGNSHEVEGTTVDLSLGGAKIESGLEVYPGKVIVIRLMIPGVEEPVSIPEALVRWVEPNQFGVEFQRVDQKELDELEELLGDFEEAEGSGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I071</accession>
    <name>A0A1W1I071_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.57</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.57" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0233"/>
    <dbReference type="EnsemblBacteria" id="SLM46405">
        <property type="protein sequence ID" value="SLM46405"/>
        <property type="gene ID" value="NSJP_0233"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0233"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="179"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="371" mass="40567" checksum="E830C63DAFAD9C4E" modified="2017-06-07" version="1">MPARLMLLAIGLGVGGTETHILELASRIDRSRYDVTVCCLKTAGCLADELRARGVRVVSLNGTGKLDALVLFRLWKLVRRERPDVIQAFLFWANMAARLLGRAMKAVPVISSYHDEVVSEGWLIRALDRLTFGWSHTIVCCSEAVRRSVSSQVCARPARYTIIPFGLDPQQFNPSDAATRQELGLSQDLPVLGTVCRLVEPKKGLSILLQALAEMRRREGSPLCQILIVGDGPARDMLQTMSEHLGIASRVVFAGCRRDIPRVLPLLHGFVMPSLYEGFGIAILEAMASGKAVIATAVGGIPEFVKQGETGLLVEPGSPLALAEAMTTLLRDQESARRMGSRGRDFVRDNFGIATVVRRHEQVYDACLAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0A3</accession>
    <name>A0A1W1I0A3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0242"/>
    <dbReference type="EnsemblBacteria" id="SLM46414">
        <property type="protein sequence ID" value="SLM46414"/>
        <property type="gene ID" value="NSJP_0242"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0242"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="314" mass="35877" checksum="5F0DD9E381BA63B6" modified="2017-06-07" version="1">MSETATKKSSRPTVFAVIPVFNRLALTRDCLRCLQAQSYSRLVIIVADGGSSDGTEDAIKREYPSVVLIRGDRELWWTGAMRVGIEYALEHRTSDEDVVLMMNNDTLIDSYYVETLVRVSREHKAAVGGLIVDSEEPSRIVDAGESIDWESYTFPVKTTVGAGEVFYDQIDLLSGRGTLVPMTMILQAGNVNAEVFPHYIADCEFFCRLRRHGFRLGVSYEAVVLAKVAETGIVLKSSRLKVREAWELLFSERSAENIRNHWRFIHHCAPVQWRSRAKRLLVLRQLRMIVLKTWMEWVAFPFLWCAQGLRRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0C8</accession>
    <name>A0A1W1I0C8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_0131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0131"/>
    <dbReference type="EnsemblBacteria" id="SLM46303">
        <property type="protein sequence ID" value="SLM46303"/>
        <property type="gene ID" value="NSJP_0131"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0131"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="139"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="319"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="436" mass="47164" checksum="F34EB39793EF8E41" modified="2017-06-07" version="1">MGNLINEALSMGWMILATLVGLLIYFQVSIHDPAAKKRAVFKTFIGILAAFLILVAVANYKNNFYGENRLLPVSLVMITATTFVMALYFTNLAALLKIGGFMFFVAAFLSGYGNWLPQVEGGFPPKEEKLDFSSMTPQQLADEGEKIIFGGIGQNKVQGAIGKGQCPLCHAFHAGMLGERAPNLLGLPERAGKERLEDPKYSKGNPAKREYADKEAFPGSGTADNGQEYIAESHACPSCYVVAGYGVKGTNDKESPMPKIHKPPISLSLPELAAVDTWLYVREGRDAPSFEDITKSYEKFIPEADRPKMQEDAPKAASALMADGSEPVDQIFAKAQCVACHTIPGIPGATGTIGPKLEEGTNAPLRIKDKEYKGMAKSTPEYIMESIVEPSTYVVKPFPDNTMPKVFGQKLSAGALKKIVDYLSQVKAGAPPPKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0F1</accession>
    <name>A0A1W1I0F1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46447">
        <property type="protein sequence ID" value="SLM46447"/>
        <property type="gene ID" value="NSJP_0275"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0275"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010702350" evidence="1">
        <location>
            <begin position="21"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="305" mass="31944" checksum="68C0E1F49554B847" modified="2017-06-07" version="1">MNWFSAIAGVIIFCAGTAEAATLTWNANTESDLAGYRVYQCAGQTCSKSTGSILTTLGKVTSFNIGTPVVTQSYFITAFDSKNNESGSSNVVVYTVSGGSTPPPTTPPPVQGVKLTVVGNPTTGPWGVSGTISDTRAMTVTVRLDGSVHHTENVAPWSFPGDDGVSVTTGTFGKGSHTVEFIFYLKGTTTEVGRASVTVQEGSTGSTPPPPPVNTVVLTVVGNPATGPWGVAAEINDQRAVMAKVWFDGAFHHDENLWPYSFPSDNGVTADKAKFGRGTHTVMFIFYLKGTTTEIGRASVTVNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0I6</accession>
    <name>A0A1W1I0I6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46520">
        <property type="protein sequence ID" value="SLM46520"/>
        <property type="gene ID" value="NSJP_0348"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0348"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013048699" evidence="1">
        <location>
            <begin position="25"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="121" mass="13317" checksum="8B9AC71F2C1CE924" modified="2017-06-07" version="1">MKTQATHTAQAGLLAAVMLLSGCAAEMTDTSAASGQPAGPRFVSQDQARELTAQYQRQASDLRALAARAEWEARWYESQLGVGDQEASRRRTQARQLWAAAEQADQLAIDYRRQVPHGQMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Q5</accession>
    <name>A0A1W1I0Q5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46459">
        <property type="protein sequence ID" value="SLM46459"/>
        <property type="gene ID" value="NSJP_0287"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0287"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="123" mass="13267" checksum="5BBA92B8332D4666" modified="2017-06-07" version="1">MENENVWVNVSEHPVSGLSNADELRVMYSGIDRGTLVMGDAVLIGGGLGRLDLTGTQPVREGMSLTLLIFLPRAEEAAGIAESRVSEVADGHFVVDLLSLVKVSTCDLELYVQQALERQKAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Y7</accession>
    <name>A0A1W1I0Y7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46529">
        <property type="protein sequence ID" value="SLM46529"/>
        <property type="gene ID" value="NSJP_0357"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0357"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="533" mass="57683" checksum="A59812C789A3BC02" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I137</accession>
    <name>A0A1W1I137_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoisovalerate dehydrogenase subunit beta</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bfmBAB</name>
        <name evidence="2" type="ORF">NSJP_0544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0544"/>
    <dbReference type="EnsemblBacteria" id="SLM46716">
        <property type="protein sequence ID" value="SLM46716"/>
        <property type="gene ID" value="NSJP_0544"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0544"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="10"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="330" mass="35842" checksum="4B0F9EBE8F8DB768" modified="2017-06-07" version="1">MTTVAASADVSYLEAISQALDEEMARDGRVFLMGEDIGAYGGAFKITEGLLQKYGEWRVLDTPLAESGFVGAAIGAAMMGLRPVVEMQFADFISCAFDQITEVAAKNHYRWGAAVPMVIRAPFGGGVHGGPFHSECPEGWFFHSPGLKLVAPSTPYDAKGLLKAAIRDPNPVIYFEHKFLYRRIKSPLPREDYIVPIGKADRKRTGNDISVITYGAMVHLALEAAQVLAPEGIDVEVIDLRTLIPLDKDMVYESVRKTGKAILLHEDNKTGGIGAEIAALLAEECFDCLDGPIVRIAPPDTPVPFSTPLEEFFLPKTAEIVEAARTLAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I151</accession>
    <name>A0A1W1I151_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 4-hydroxyphenylpyruvate dioxygenase</fullName>
            <ecNumber evidence="6">1.13.11.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_0539</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.27" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0539"/>
    <dbReference type="EnsemblBacteria" id="SLM46711">
        <property type="protein sequence ID" value="SLM46711"/>
        <property type="gene ID" value="NSJP_0539"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0539"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid family metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="PTHR11959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="5">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="195" mass="21732" checksum="B1A222EE5AA89450" modified="2017-06-07" version="1">MDHSTGIDHITLCVENLDAAEYLFTKVLGFEVIWSARDVGTEKSSMDTVVVQRGSAKIALMQGRNKTTKSQISQFVERYGQGVQHFALEVDDIEAACREWETHGVQFSGSVKEGRDGFGPLKQRFTFPLFPGSGLFIELTQRVHGDEKAKTFVRSTVESLYKDIEQDQASGVERTIIDYGSSPIPGRKKPLKRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I182</accession>
    <name>A0A1W1I182_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxiredoxin</fullName>
            <ecNumber evidence="5">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_0580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.15" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0580"/>
    <dbReference type="EnsemblBacteria" id="SLM46752">
        <property type="protein sequence ID" value="SLM46752"/>
        <property type="gene ID" value="NSJP_0580"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0580"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="8"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="156" mass="17563" checksum="890EA2CA30926569" modified="2017-06-07" version="1">MSDVAPEIKVGDTAPDFNLKDQDQKDVKLSDFRGKKNVVLAFYPLDWSPVCQGENKCLTDDFPKFQNANAELFGVSCDSFFSHKAWADSMDLKHRLLSDVHRTTAKAYGLYFEPLNCSKRATVIVDKNGKVAYVKVQEIKVAREDKDILAELAKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I184</accession>
    <name>A0A1W1I184_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46629">
        <property type="protein sequence ID" value="SLM46629"/>
        <property type="gene ID" value="NSJP_0457"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0457"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="50" mass="5272" checksum="FF88E094C9BAFC79" modified="2017-06-07" version="1">MAVWEEAQASAADQAEAAVEAEMDRDPAEPVRDPELDSVCASDRIAIGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I185</accession>
    <name>A0A1W1I185_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Iron-sulfur cluster assembly scaffold protein IscU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">iscU</name>
        <name evidence="5" type="ORF">NSJP_0572</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0572"/>
    <dbReference type="EnsemblBacteria" id="SLM46744">
        <property type="protein sequence ID" value="SLM46744"/>
        <property type="gene ID" value="NSJP_0572"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0572"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISC_FeS_clus_asmbl_IscU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="4">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="127" mass="13757" checksum="3D690A85D84694EC" modified="2017-06-07" version="1">MAYSDKVVDHFNNPRNMGSFKKDEDGVGTGMVGAPECGDVMKLQIKVQNDTIVDAKFKTFGCGSAIASSSLATEWLKGKTLEEAQKIKNTDIVQELNLPPVKIHCSVLAEDAIKAALADYHKKSDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1A2</accession>
    <name>A0A1W1I1A2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rmlC</name>
        <name evidence="4" type="ORF">NSJP_0589</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0589"/>
    <dbReference type="EnsemblBacteria" id="SLM46761">
        <property type="protein sequence ID" value="SLM46761"/>
        <property type="gene ID" value="NSJP_0589"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0589"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="193" mass="21647" checksum="635A1BC78BDC8F90" modified="2017-06-07" version="1">MRVTTIDIPGVLLLEPTVLRDHRGFFAETYQVQRYRDAGLAESFVQDNLSRSVRGTLRGLHFQEPHAQGKLIMALEGSVYDVVVDIRVGSPTFGRWYGLELSDGNLRQIYVPPGCAHGFCVTSETAIFLYKCTDYYSPRHERGVLWNDPALAISWPISDPILSAKDRQYPPLAAMKDELPSYRAASNAGLKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1B8</accession>
    <name>A0A1W1I1B8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46806">
        <property type="protein sequence ID" value="SLM46806"/>
        <property type="gene ID" value="NSJP_0634"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0634"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="76" mass="8903" checksum="48DF5DFA59CAC41A" modified="2017-06-07" version="1">MINPHKSDDGLWYADAWYGVLDTDQDESIFKRVPSTDHRDLEHSVMSAKRAALQLLWKQGIEEKHVVLNIIWPEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1G3</accession>
    <name>A0A1W1I1G3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46824">
        <property type="protein sequence ID" value="SLM46824"/>
        <property type="gene ID" value="NSJP_0652"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0652"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="152" mass="17264" checksum="88E5B88A483D03BF" modified="2017-06-07" version="1">MPRYSSFLLVVIGVLSLNGCAMYTSPSTYFADRSARKDIAAQAKDANQVQTLLNLITMMETSAKGAEGGKGYDQPFRDLHNQFHAYDKEFCSLDKATRAKPAYDLAVTHNKELWAIFLRTWKFKDDQPQRQQHVALFAAEVKELRETIEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1H8</accession>
    <name>A0A1W1I1H8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46858">
        <property type="protein sequence ID" value="SLM46858"/>
        <property type="gene ID" value="NSJP_0686"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0686"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="286" mass="32375" checksum="51A8C86FAB5976FA" modified="2017-06-07" version="1">MNVRAAYGWTFMAGVLVASLVLGGAAARQASDRERDGLVGLVHRVVSTTGGTSVTNTYSRDGILLETVTRNAPPADQPDVGERMERVVYEYDAQGRRQRDMIDEGDGYRYLSRVYAYDQDGKVLAEASYSMCGTFSSLTLYTYDDAGRVQEDLSYRLRSLFKRTHEFDSHGRMTLRRNYKNNGAISSTGYRYDEHGRLAEESELRPDGTLERKVSYRYDWQGNQILEETTNLADSSLNGTRASSYEYDAQGNWTARTVQHPVVPRGEETSVEITRRTITYYDHPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1U2</accession>
    <name>A0A1W1I1U2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46793">
        <property type="protein sequence ID" value="SLM46793"/>
        <property type="gene ID" value="NSJP_0621"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0621"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="185" mass="20399" checksum="A7A681B2CD7E03CC" modified="2017-06-07" version="1">MPFFGTIDPMESDPLGLLTVHDFDGVAVQHAHHFAREICPPDHRGKDEQHTDNSGPQAHCEALLSCLPICSRRLRCPFRKKLVKVLPGFRIDHQRFHAIFLGSHPSNNGRGHINLLVRGQRHRERTDLTDTQGEITGEAPAHRGDIPDHAEAFELLNLVGHGAAQGDPTEGTNGEVHEDLAGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Y8</accession>
    <name>A0A1W1I1Y8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47026">
        <property type="protein sequence ID" value="SLM47026"/>
        <property type="gene ID" value="NSJP_0854"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0854"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="187" mass="20697" checksum="3EF061FBFEFDF615" modified="2017-06-07" version="1">MHPSSHLIVSWLVGQHLSERRDRVLVAYAGVAPDLDGLSLLAGVDAYGQWHHVLTHGVMGAALVAVMTARLAKDRLRVALMALTAFHLHLLCDFFGSGHGWGLTYWYPFSTWEYMSPLQWDLNAWPNVLATALALGLSGWLAVRHGHSVAETVLPARWDAVIVETLKNRFGNTHHVHPEKLRASANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Y9</accession>
    <name>A0A1W1I1Y9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoesterase</fullName>
            <ecNumber evidence="2">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_0832</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0832"/>
    <dbReference type="EnsemblBacteria" id="SLM47004">
        <property type="protein sequence ID" value="SLM47004"/>
        <property type="gene ID" value="NSJP_0832"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0832"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="4">
        <location>
            <begin position="5"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="193" mass="21110" checksum="64300929791EE3E9" modified="2017-06-07" version="1">MDVHVGIIADTHGLFDPALRRHFQGVDRIIHAGDIGDIAVIDELQRIAPVVAVSGNVDRGQAGKFPAETVIDLAGYRIAVRHVIYEGGKIRRDARRFLDRVEPDICIFGHTHKPCIEWIGRLLLFNPGSAGPRRFSLPRSLGLLTIRNDGREVVHVPLAGRAERPPSAEGRGAGGLRSNHVVQSHGRSIRARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I235</accession>
    <name>A0A1W1I235_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47055">
        <property type="protein sequence ID" value="SLM47055"/>
        <property type="gene ID" value="NSJP_0883"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0883"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031009">
        <property type="entry name" value="Tcm_partner"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04474">
        <property type="entry name" value="tcm_partner"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="275" mass="31518" checksum="7B85C28A15EA8DCA" modified="2017-06-07" version="1">MADSNIDEIGPWSEVKLDIIREYAQAYSQILSAQKEPRLYHIYIDAFAGAGVHLSRATKEFVPGSPLNALNVSPPFAEYHFIDIDQARVDSLQQVAQQRQNVFVHEGDCNQVLLGKVFPRVQYKDYRRGFCWLDPYGLHLDWKVIYTAGQMKSVEIFLNFPIMDMNMNVLKHDPESVPSEQAERMTRFWGDGSWKSAAYSTTGNLFGYEEKLDNETVTKAFRERLLGVAGFKHVSKPLAMRNSRGAVVYYLFFASPKPVALRIVKDIFKKHEKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I283</accession>
    <name>A0A1W1I283_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoaspartyl peptidase</fullName>
            <ecNumber evidence="4">3.4.19.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">iaaA</name>
        <name evidence="4" type="ORF">NSJP_0932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.19.5" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0932"/>
    <dbReference type="EnsemblBacteria" id="SLM47104">
        <property type="protein sequence ID" value="SLM47104"/>
        <property type="gene ID" value="NSJP_0932"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0932"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008798">
        <property type="term" value="F:beta-aspartyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="PTHR10188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="171"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="194"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="142"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="276" mass="28699" checksum="2D259D8369610277" modified="2017-06-07" version="1">MTSQQVQSLKLALEAGYGILQRGGPSLAAVECAIGILEEGGAFNAGRGAYRQLDGVRRMDASIMEGKGLRAGAVASVEGVVHPITAARLVMEKTDHVLLVGPSATKFARHFKLQRLPPTQARQGLSYDRLLARTSMTGERHGTVGAVALDQAGTVSAGASTGGIERMLPGRVGDTPLIGCGVYADDRAGGVSMTGVGEGIIRLAVAGIVCERLAEGKSPAAAARRILNQLVSRIQGVAGMLVVAPDGRFAIAHVTPRMAAGWWRGTGSPIVKDRWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2C0</accession>
    <name>A0A1W1I2C0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47009">
        <property type="protein sequence ID" value="SLM47009"/>
        <property type="gene ID" value="NSJP_0837"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0837"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="867"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1322" mass="142506" checksum="1A6A979F642AFC2A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2F1</accession>
    <name>A0A1W1I2F1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0979"/>
    <dbReference type="EnsemblBacteria" id="SLM47151">
        <property type="protein sequence ID" value="SLM47151"/>
        <property type="gene ID" value="NSJP_0979"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0979"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038767">
        <property type="entry name" value="Transcriptional_reg_pdt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40663">
        <property type="entry name" value="PTHR40663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="101" mass="11769" checksum="4B530E59DDD47137" modified="2017-06-07" version="1">MYSRSQTLRQQLSLLLTGTSRTARQLAALVSISERQVEEHLEHVVRSLARDYSRRFILRPSACHECGFAFRDRTRLTRPSRCPRCRSEAISAPEYMIETRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2F3</accession>
    <name>A0A1W1I2F3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0831"/>
    <dbReference type="EnsemblBacteria" id="SLM47003">
        <property type="protein sequence ID" value="SLM47003"/>
        <property type="gene ID" value="NSJP_0831"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0831"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021383">
        <property type="entry name" value="DUF3015"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11220">
        <property type="entry name" value="DUF3015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013229776" evidence="1">
        <location>
            <begin position="26"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="173" mass="18669" checksum="B72DAC2EC1839D5C" modified="2017-06-07" version="1">MTPLFKGTIAFLLSASFWPATIAYSATTNPDTGPGCGLGRQLWEDWKGKKQIAPQLFMASTNVTGSYTFAITSGTSGCSNDGTIWDSQKAGLFIDINYANVMDDMARGGGEHLASLAALLGVTQEEESIFFSLVQREAFFAAHGEPALLLERLVAVRHDLSQRRMLAASATRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2G0</accession>
    <name>A0A1W1I2G0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:48908"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:12252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90840"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1000"/>
    <dbReference type="EnsemblBacteria" id="SLM47172">
        <property type="protein sequence ID" value="SLM47172"/>
        <property type="gene ID" value="NSJP_1000"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1000"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037919">
        <property type="entry name" value="OGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366">
        <property type="entry name" value="PTHR44366"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="260"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="294"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="345" mass="39106" checksum="A7A9A13325FE270F" modified="2017-06-07" version="1">MSDHRTTCETSLLEGDWERAAQAAMDWVRHPSVAEERDPRPHFVLNVTHLLKGRFAEAWASHAECLQEAEDIAQIKEWTEDLVETHGDQTSAHLIMGLFLAQSGQSEQSQQSYKEAAKLAPASAYPHYFQAQIHERADRPDMAIKEYREAVRLDPGFAPARTNLGVAYQEQGRLEMAIPQYREVIKLNPDDSVAHANLACALAEQGKQEAAVQAYKEALRLNPHDAEVRFALGSLYETRSRMDLAKKEYSEALRSNPDFGPAHTALGWIALRKGHLQDAYEAFNRGLKTNEQDARAYHGIAEYYAQRRKPESAMDNYAKALKYYKDPDMKNTIMNQLFQEGRVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2I6</accession>
    <name>A0A1W1I2I6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0861"/>
    <dbReference type="EnsemblBacteria" id="SLM47033">
        <property type="protein sequence ID" value="SLM47033"/>
        <property type="gene ID" value="NSJP_0861"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0861"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="101" mass="11089" checksum="4AB306C414DEE4DE" modified="2017-06-07" version="1">MKARLVSTLVVFVLLLLPLVPIALPPYATAAAEKGAAEADLLDINTATAEQLKALPGIGDAYSEKIIKGRPYTRKDELVQKQILPRATYEQIKYKIIAKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2P4</accession>
    <name>A0A1W1I2P4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized ABC transporter ATP-binding protein YbhF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybhF</name>
        <name evidence="5" type="ORF">NSJP_1105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1105"/>
    <dbReference type="EnsemblBacteria" id="SLM47277">
        <property type="protein sequence ID" value="SLM47277"/>
        <property type="gene ID" value="NSJP_1105"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1105"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="13"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="342"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="374"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="654" mass="71727" checksum="86D419E7DE622BEB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2W7</accession>
    <name>A0A1W1I2W7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Amylo-alpha-1,6-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.33" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1178"/>
    <dbReference type="EnsemblBacteria" id="SLM47350">
        <property type="protein sequence ID" value="SLM47350"/>
        <property type="gene ID" value="NSJP_1178"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1178"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032856">
        <property type="entry name" value="GDE_N_bis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14742">
        <property type="entry name" value="GDE_N_bis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_N_bis" evidence="2">
        <location>
            <begin position="11"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="GDE_C" evidence="1">
        <location>
            <begin position="277"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="714" mass="80628" checksum="C66D80276D7CEC40" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I323</accession>
    <name>A0A1W1I323_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47407">
        <property type="protein sequence ID" value="SLM47407"/>
        <property type="gene ID" value="NSJP_1235"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1235"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="55" mass="6425" checksum="F3F699062106040B" modified="2017-06-07" version="1">MRMARLNIQLPKPLKTKLDAQRQRGTTASGLIRHLLEEHFNTDRRRTGRNAPRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I327</accession>
    <name>A0A1W1I327_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional regulatory protein ZraR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">zraR</name>
        <name evidence="9" type="ORF">NSJP_1117</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1117"/>
    <dbReference type="EnsemblBacteria" id="SLM47289">
        <property type="protein sequence ID" value="SLM47289"/>
        <property type="gene ID" value="NSJP_1117"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1117"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="18"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="157"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="470" mass="52696" checksum="72368A3761EEDE19" modified="2017-06-07" version="1">MPIEFDRKGIVMTEEWGAVLVVDDDEALRETVSDLLKDRGHQVTTAANGAEALVRLKEADYAAVLTDLRMKGVEGLELLSAIKRLYPDIGVVLMTAFGSVETAVEAMKHGASDYLTKPVKKEELLRVIERVIREASLRREVSRLRKEVHKEYSFHQILGKSKPMQTLFDLIQRVADSPSNILITGESGTGKELVAKAIHYNSDRKASPFVPVNCAAIPEQLLESELFGHVRGAFTDAKADKRGLFEEAQKGTLFLDEISELPLILQAKLLRAIQEKDIRRVGATKSVAVDVRVIVATNLNLAEEVKARRFRDDLYYRLNVIELKLPSLRERREDIPLLIEAFLRKCGHARGNGVKAVGESALAMLIDYDWPGNVRELENVIERAVTLSRGEKILPEDLPAPVQGSRGDRRILDEAAEKTLPLHEVEKEYIRKILEKTGGNKYRAAHLLGIDRKTLYRKLDEIEGTAQAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I330</accession>
    <name>A0A1W1I330_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47371">
        <property type="protein sequence ID" value="SLM47371"/>
        <property type="gene ID" value="NSJP_1199"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1199"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="10"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="156" mass="18046" checksum="470ABCBAA9FFFC34" modified="2017-06-07" version="1">MQVKKREDALALLLRDHERARTLYEAFETAGGDDRYFIASRILRILELHGQMENELFYPVLAAHMSTADPGAKALASAARDHEQLHKRIEQVRDVLAHDEEFQAEIDRLMADVSRHFEEEEQRIFPLARTLLSAAELMQVADDIHRMKEEDPRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3A6</accession>
    <name>A0A1W1I3A6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47497">
        <property type="protein sequence ID" value="SLM47497"/>
        <property type="gene ID" value="NSJP_1325"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1325"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="164" mass="18359" checksum="96D349C3B9C04FA3" modified="2017-06-07" version="1">MNRYDMLQCPMQADSSADSAQYRVTLFFGPEPVEAHPSTQACVFNVKKRSWKGGIQVLVEATEAQIDASRTSIHFSQWLTEALGDATGEERAAQEARASELFVQALCRCRLDRLLQAGITQENQRLTADAWNAQEHADLIKRRDFIRAYVAAEMDLQPGDPTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3F6</accession>
    <name>A0A1W1I3F6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine protease Do</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">degP</name>
        <name evidence="7" type="ORF">NSJP_1356</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1356"/>
    <dbReference type="EnsemblBacteria" id="SLM47528">
        <property type="protein sequence ID" value="SLM47528"/>
        <property type="gene ID" value="NSJP_1356"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1356"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011782">
        <property type="entry name" value="Pept_S1C_Do"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02037">
        <property type="entry name" value="degP_htrA_DO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012732206" evidence="5">
        <location>
            <begin position="29"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="289"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="415"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR611782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="501" mass="51880" checksum="D68CA71605B12482" modified="2017-06-07" version="1">MSSFHVLGRKAGLAVAAVALGATLTLGAQPFMASHASESPSAAPVATAVPVAMPAAGFTDVAKAVTPAVVNITTVLTDKGGDGRNVPDEPRDRMEEFFGAPFGPRGFRGPQGPPEPRGHRGGGQGSGVIVSADGYILTNNHVIDGAREVSVTLPDKREFTGKIVGTDPKTDLAVVKIDAQNLPSVMWGDASKLQVGEYVLAVGNPFGLNSTVTLGIVSALGRGRMGITQYEDFIQTDAAINPGNSGGALVNTKGELVGINTAIFSQTGGYQGVGFAVPTSMSKPIYDSLIKNGKVVRGFLGIGIQDLNGDLASSFGIKDAKGALVSDVREDSPADRGGLKQGDVIVSYQGSPVEDAVALQRLVTRTAVGAKTTLKVVRDGHEQDVTVTIGEQPDTSKIAKAESTDKNYALAGLAVQDLDRDMAKELGLKGHSHGVVVTGVAPDSGADKAGLMPGDVIREINRQPVKSVKEFEKVSSAVKKGDNVLILINRRGNALFLSAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3K0</accession>
    <name>A0A1W1I3K0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">6-phosphogluconolactonase</fullName>
            <shortName evidence="7">6PGL</shortName>
            <ecNumber evidence="5 7">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pgl</name>
        <name evidence="9" type="ORF">NSJP_1400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="5 7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1400"/>
    <dbReference type="EnsemblBacteria" id="SLM47572">
        <property type="protein sequence ID" value="SLM47572"/>
        <property type="gene ID" value="NSJP_1400"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1400"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="8">
        <location>
            <begin position="15"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="255" mass="27666" checksum="E3CEBEAB7336B5CF" modified="2017-06-07" version="1">MTMRPDIRISPDAGWADATAILLRELGRQAIRLRGRFLLALSGGSTPQRLYQALAQPAKSQTEMDWHRTVFLFGDERCVSPDHPDSNYGMARASLFAPLDIPPGHVHRMSGENPDPRAAADEYERSLRTVVGCTEPEIPSLDLVLLGLGEDGHTASLFPGTTTLLESHRLVTVGRSPKGIPLRLTLTLGVINRASVILFLVTGSTKAQIVRRILAPQTAADRALPAALVTPEPGHLIWMLDQAAASELPSHNKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3K9</accession>
    <name>A0A1W1I3K9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="7">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">mnmA</name>
        <name evidence="8" type="ORF">NSJP_1416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1416"/>
    <dbReference type="EnsemblBacteria" id="SLM47588">
        <property type="protein sequence ID" value="SLM47588"/>
        <property type="gene ID" value="NSJP_1416"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1416"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="360" mass="40065" checksum="3515EC3195FF9887" modified="2017-06-07" version="1">MTRPTVLLGMSGGVDSSVAAALLVRQGYDVRGVTLQVWEPEGDDAPVSKKWQERGCCKIGIAKFVSNRLNIPYEVIDTRQAFRQGVIDDFLRGYREGTTPNPCVRCNERVKLRHLIELAEARGIQYVATGHYVRTGQRDGQTALYRSVDVKKDQSYFLYRLRADWLPRLIFPVGGMHKTEVWREAEALGLPADELKESQEICFVSRGDYRTFIEAEMPEAKKAGAFVDREGRYLGAHDGVAFYTPGQRRGLGVATGQRLYVQEVHAATNIVVLGPEDSLARDSCQVDDLNLLDPRLFTGPIRAEVKIRHATPACLATIEPVDQTAVRIRFDQPLRAVSPGQSAVFYQEDAVLGGGIIRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3L9</accession>
    <name>A0A1W1I3L9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CBM20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1445"/>
    <dbReference type="EnsemblBacteria" id="SLM47617">
        <property type="protein sequence ID" value="SLM47617"/>
        <property type="gene ID" value="NSJP_1445"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1445"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM20" evidence="1">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="110" mass="12628" checksum="0B86661AC519085F" modified="2017-06-07" version="1">MKKPSPLKKPVLPRTSPRRSLKRSVTFEYFDPSATTVTVAGTFNQWNPEARPLKPDTGGLWKVTLRLESGIYQYKFVINGQRWEEDPLNLDRIANEHGTFNSVRTIDPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3S9</accession>
    <name>A0A1W1I3S9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rplT</name>
        <name evidence="8" type="ORF">NSJP_1453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1453"/>
    <dbReference type="EnsemblBacteria" id="SLM47625">
        <property type="protein sequence ID" value="SLM47625"/>
        <property type="gene ID" value="NSJP_1453"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1453"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="122" mass="13637" checksum="293EF73FD75F8870" modified="2017-06-07" version="1">MPRVKGGPKTRARRKKRLKLAKGQYGAKSRLFRSATESVDKGQQYAYTGRKNRKRDFRQLWIARISAATRAQGLSYGRFISALKKANVLLDRKILSDMAIKDAAGFEQLIGLAKKQLTPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3X5</accession>
    <name>A0A1W1I3X5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Acyltransferase</fullName>
            <ecNumber evidence="2">2.3.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1479"/>
    <dbReference type="EnsemblBacteria" id="SLM47651">
        <property type="protein sequence ID" value="SLM47651"/>
        <property type="gene ID" value="NSJP_1479"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1479"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="31"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="212" mass="23368" checksum="9191E4B258757A82" modified="2017-06-07" version="1">MYWWLWVLTRAVGWILLGYRVEGQVPRRGGMLVAANHASYADIPLLGCGMRRRAWYLGRSDLFVPGVKGLLQWLGWIPLKLGRLDRRAFEKAVALIQQGKVVVIFPEGGRTLTGHLREAKPGLGMIVAQTGCPVVPAYLNGTYEVLPPGAKRPRRHPVTVRFGEPMTFGRPADGGDTKQFYRHVSRAVMERIAALGGVEPPGHGPGSRSAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Z6</accession>
    <name>A0A1W1I3Z6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-type ATPase subunit delta</fullName>
            <shortName evidence="6">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">atpH</name>
        <name evidence="7" type="ORF">NSJP_1417</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="6">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1417"/>
    <dbReference type="EnsemblBacteria" id="SLM47589">
        <property type="protein sequence ID" value="SLM47589"/>
        <property type="gene ID" value="NSJP_1417"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1417"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="SSF47928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="2 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="179" mass="19363" checksum="27B3F4EE3A064633" modified="2017-06-07" version="1">MIKTAVARRYAQALFELLDPSSIEATRGTLDGLGQAMKESASLRHVVASPAFGVDDKITVLTELGNRLGCPPAAKAFFAQLVKKHRVAFLPEIAEAFANLVDRSKGTQHVLVSSAIALPSAEQDRIKARLRDTLKREVDVAFQTDAALLAGLQIQIGSRVVDSTVRGRLNTMRAALTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4A8</accession>
    <name>A0A1W1I4A8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1668"/>
    <dbReference type="EnsemblBacteria" id="SLM47840">
        <property type="protein sequence ID" value="SLM47840"/>
        <property type="gene ID" value="NSJP_1668"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1668"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="368" mass="40672" checksum="EBF81A94031450B3" modified="2017-06-07" version="1">MWLSVGQALGNGVPLTLPLDDLGLDGPLVRPDEILREIPIVPWLYHIDGYGALLKTFQEAGLTVVSMDYDWRDDLMRAVRHLDETVVNLKRRGIDRIALVAHSMGGLIASYYLRYGAQEIQTATETWKGANEVRTVVLAGVPFDGSMATFRNMIYGRPIGLNDTLLNFEAVSSFPASYYVLPRADSDRLLTPNGTERQGLIGDASNWARYQWGLLRDKDGLAPDVGNKRLAYTVRWLEIAGRFHDLVNRPSTHDRAAGCSLMSIVGIGTSTLAKGRLNDHATGRSSVRFDDGVSSRQAGVQENSVFEDGDGTVTRRASVPPDAYAKRLALNGRTYEATHIDLMNRKDIRRDILNFVVEGLALTPASER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4D5</accession>
    <name>A0A1W1I4D5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47866">
        <property type="protein sequence ID" value="SLM47866"/>
        <property type="gene ID" value="NSJP_1694"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1694"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="110" mass="12507" checksum="76F80125F8CE9FEE" modified="2017-06-07" version="1">MTDPDFGRSSDDPRWQQVLAQSVHYVLAPLILFSSGFFTANFLISGQYTWPRTSRAAALTLTVLVLCYEFVYKEHRTRTGSHEQARAVVLYACVIPYIMGAMIMVALWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4N0</accession>
    <name>A0A1W1I4N0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1667</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47839">
        <property type="protein sequence ID" value="SLM47839"/>
        <property type="gene ID" value="NSJP_1667"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1667"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="143" mass="16299" checksum="F50B75B2029FF3B2" modified="2017-06-07" version="1">MRRFKFILKWIFGVLFVLAGLNHFRVTDFYLRMMPPYLPWHLASVYVSGIAEIALGALLLVPRLQRLAAWGLIALLVAVFPANVHMAVHPELFPEFDAALLWWRLPVQALLIGWACWYTGGSVKHGNITAQTPVLKPIPRRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5E7</accession>
    <name>A0A1W1I5E7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="2 3" key="1">
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            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48109">
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        <property type="gene ID" value="NSJP_1937"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1937"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="162" mass="18228" checksum="CB53AB458FF59397" modified="2017-06-07" version="1">MVSNRLRDTLLVVGVLIGVLVAPWLIGYGKAQKTILGAVPDYLARCVPNWSVISWYRDQELFIPVDEFERYLEKGCGGAERLRYPPGQYISNSLVVFLQHHLDRWYFMGYQTGEDHALKGILPAWNRVVNTSDMTGKVLVSILALVVAGGCALGFYILRRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5H4</accession>
    <name>A0A1W1I5H4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48268">
        <property type="protein sequence ID" value="SLM48268"/>
        <property type="gene ID" value="NSJP_2096"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2096"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="41" mass="4429" checksum="D96031DFE9F38582" modified="2017-06-07" version="1">MVDVGAEVEFLLEKNVAPVKVVAPQMVVLYGKMSANHNAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5S6</accession>
    <name>A0A1W1I5S6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2011</name>
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    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48183">
        <property type="protein sequence ID" value="SLM48183"/>
        <property type="gene ID" value="NSJP_2011"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2011"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="43" mass="4547" checksum="DEB5B6EC35F670C2" modified="2017-06-07" version="1">MRDLIALAIGGLFSVVLVSDCSAWVLPSVLPVKSGLSSHRVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Y5</accession>
    <name>A0A1W1I5Y5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48422">
        <property type="protein sequence ID" value="SLM48422"/>
        <property type="gene ID" value="NSJP_2250"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2250"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="123" mass="13555" checksum="6A493548A93CA253" modified="2017-06-07" version="1">MGNCRTARWLTSKVKILSCLLLIYGTLMLGGCINITTRIQPENKDIPAKKEGSDCVPIILGFGAGTADIDAAMIKEYEENAKGMDGDVVRTVRTPYITRVRRIEIQEIMFLSFGARCVNVIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Z4</accession>
    <name>A0A1W1I5Z4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Histidine kinase (Modular protein)</fullName>
            <ecNumber evidence="8">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_2254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2254"/>
    <dbReference type="EnsemblBacteria" id="SLM48426">
        <property type="protein sequence ID" value="SLM48426"/>
        <property type="gene ID" value="NSJP_2254"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2254"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="251"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="491"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="639"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="545"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="762" mass="84682" checksum="9A16FF59AD9A4A02" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I664</accession>
    <name>A0A1W1I664_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized endonuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48465">
        <property type="protein sequence ID" value="SLM48465"/>
        <property type="gene ID" value="NSJP_2293"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2293"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="136" mass="15327" checksum="37234AED87E57572" modified="2017-06-07" version="1">MQGQQALRIRLNEIDCPEKRQAYGTKAKQAASGLVFGKEVTVHTHGMDKYGRTIADVLLPDGTNVNHALVKGGWCWWYRKYAPTDVTLEQLEQSARAANLGLWADPQPIPPWEYRKAVRGKAPAWLDPELEEGMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I688</accession>
    <name>A0A1W1I688_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SASA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2217"/>
    <dbReference type="EnsemblBacteria" id="SLM48389">
        <property type="protein sequence ID" value="SLM48389"/>
        <property type="gene ID" value="NSJP_2217"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2217"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005181">
        <property type="entry name" value="SASA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03629">
        <property type="entry name" value="SASA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010723470" description="SASA domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="SASA" evidence="3">
        <location>
            <begin position="44"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="275" mass="30038" checksum="4FEA7612B0FC235E" modified="2017-06-07" version="1">MRVLFFTLLLVLTHLPLMAEEVPSGPSSREEVPLSPISDRHTMVALVLGQSNAANHGESRWVSTQRVYNFYQGKLYHAEDPLLGATGDRGSVWTRLGDLLVTDGDYDAVIFVAIAVGSSAVSQWAPGGDLSSHLQATLNDTQKAGLPITHIFWHQGEADAHVTSKTVYMQQFRDMVRAIRENGITAPIMVSIATVCGGNMTVDTTIQQAQKELVDPQNGIFAGPNTDDLGEAFRFDRCHFSTKGLDEAARLWHHALRKASLSEGHEAQAHPAIMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6D9</accession>
    <name>A0A1W1I6D9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rplD</name>
        <name evidence="7" type="ORF">NSJP_2339</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2339"/>
    <dbReference type="EnsemblBacteria" id="SLM48511">
        <property type="protein sequence ID" value="SLM48511"/>
        <property type="gene ID" value="NSJP_2339"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2339"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="207" mass="22187" checksum="4A4CBD108E264FD4" modified="2017-06-07" version="1">MPTVDVIDVNRRKVGSAELPAEVFGCQPHAALVHEAVVMQRACERQGTASTLRRGEVSGSGKKPWKQKHTGRARAGSLRSPVWRHGGSVFGPKPRSYAFSMPKKKYRAALQSALSAKVAGGHVVVMSDLSLAQPKTKVLAKTLSQFGDGVHILIVAGEGQTGLIQAARNLPTVAVVAPDQLNVYDVVRAGTIVIPERELARVKEVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6I3</accession>
    <name>A0A1W1I6I3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2413"/>
    <dbReference type="EnsemblBacteria" id="SLM48585">
        <property type="protein sequence ID" value="SLM48585"/>
        <property type="gene ID" value="NSJP_2413"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2413"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="137"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="202"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="260" mass="29077" checksum="D7FAB5A21952799A" modified="2017-06-07" version="1">MPRRSRTGLQRADILERYLARFRKQLGTFQMFLSRKRPSMPLEDFDEAAEELISQVYGQASDEVEAYFYAKSGEAANLPEEAQENGTHDVERESLQQRRQVLESCLSDLEMRYRLQAKRQPGANGQAMGKRTVEDYMSHEVHSIHRAATIKEAGRLLQKYKVGSLIVDDGSRYIGIVTDSDLSRKAVAKGLDPNTTAVLACMSKPVVSIEETEPISEALGLMKQEKIRHLAVTADRTIIGVLSISDVLRAYEEVTGSPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6L5</accession>
    <name>A0A1W1I6L5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">nrgA</name>
        <name evidence="11" type="ORF">NSJP_2399</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2399"/>
    <dbReference type="EnsemblBacteria" id="SLM48571">
        <property type="protein sequence ID" value="SLM48571"/>
        <property type="gene ID" value="NSJP_2399"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2399"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012890389" description="Ammonium transporter" evidence="9">
        <location>
            <begin position="25"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="10">
        <location>
            <begin position="42"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="425" mass="44031" checksum="2E3144A44361FA71" modified="2017-06-07" version="1">MKKWRLFMWTVAATLPAWTAVARAEDALGAVPAAGLQSGDIAWMLAASALVTGMIVPGLAFYYGGLVRSKNVISTMVQSFGILCVVSLIWILFGYSLAFAPDRGGVVGGLEWMLLSGVGASPNPMYAPTIPHQAFMLFELLFAAFTPALIAGAFAERIKFGSMLLFAGLWSAVVYAPLAHWLWGGGWLMKLGAVDFAGGAVVHVSAGFSAVACAMAVGKRRGWRTDYMAPHNLPFILLGAGMLWLGWFGFNGGSARGANAVSVNAIVVTHLTAVSAAMSWMVAEWKHRGKPTVLGIASGAIAGLATSTAGAGFVGPLAGVALGIAAGLCSYLAIVWKGKIGYDDTLDVMGTHGVGGILGMLGVGLFAANGHLAVQLVAVVASGAYSFIGSYALLKLVDGAGGLRVTPEEESTGLDLTQHNERAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6U4</accession>
    <name>A0A1W1I6U4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dipeptidyl aminopeptidase/acylaminoacyl-peptidase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2553"/>
    <dbReference type="EnsemblBacteria" id="SLM48720">
        <property type="protein sequence ID" value="SLM48720"/>
        <property type="gene ID" value="NSJP_2553"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2553"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="165"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="399" mass="44189" checksum="3BBD5E11E0E6BD69" modified="2017-06-07" version="1">MLSGDTFFEEQAMRTLSHTQFGGADFGECMVTMQRVPPGDMAAWHREWTATADRVAAIGDACAADGHAVSAREAYLRASNYYRTSYLMLFGTPVSPELMHAFERESATFREFASRADPPLEPVEIPYEGTTLPGYFCPSARAKGRAPTLIATNGYDSTIHEMYFAFAVAANRRGYHCLLFDGPGQGRALIKQRLPIRPDWEQVIRPVVDYALTRPDVDPSRLALAGWSFGGYLSLRGAGGEPRLGACIADPALIGLWEPMKKMFAELPPDALANPRAADPALFAPYIARIESSPVMRWKVVRRAFWVHGIQSLADYLAIAREFDNRQALQSIRCPVFLAWEENDSLAATAPQVFDGVTGQKTLVRFLASEGADGHCAMKARSLFHQRMFDWLDSVLPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6U7</accession>
    <name>A0A1W1I6U7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atoB</name>
        <name evidence="7" type="ORF">NSJP_2591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2591"/>
    <dbReference type="EnsemblBacteria" id="SLM48758">
        <property type="protein sequence ID" value="SLM48758"/>
        <property type="gene ID" value="NSJP_2591"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2591"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="8"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="270"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="392" mass="41122" checksum="8DE76C06B7D6E886" modified="2017-06-07" version="1">MNNQPQSVIVSAVRTPMGSFNGAFSTVPATRLGSIAIAEALRRTGVSPDRVDQVLMGCVLSAGLGQAPARQASIGAGIPYSVGATTVNKVCGSSIATVMMAAQAIALGEARVVVAGGMENMTRAPYLLEKARQGYKLGHAELVDSLIKDGLWDVYNDFHMGDAGELCAGKYGLTRQELDDFALESYRRARQTIEAGLFRSEIVPVDVVQRKGTVTDDEEPNRVDLGKLRHLVPAFRPDGVLTVGNSPSCNDGAAALVVMASEEAETLGLTPMARIVGYASAALAPEWLTIAPVEAIKLVLKKTGFSLTDIDLFEINEAFSAVSLAVNRELGLDGRKVNVRGGAVSLGHPIGATGARILTTLLHAMPAMDAKRGLASLCIGGGEALAIVVERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6X5</accession>
    <name>A0A1W1I6X5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">dxr</name>
        <name evidence="11" type="ORF">NSJP_2621</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2621"/>
    <dbReference type="EnsemblBacteria" id="SLM48788">
        <property type="protein sequence ID" value="SLM48788"/>
        <property type="gene ID" value="NSJP_2621"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2621"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="4"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="144"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="259"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="386" mass="42487" checksum="1E3FAFF2E7F87477" modified="2017-06-07" version="1">MKTIVILGSTGSIGTNTLDIVSRFPDQFRVAGLTAGNNDDMLDDQIRRYKPRVVALANDAAAARLRRRCSDVSVEILSGQDGLAHVAALPEAELVVSAIVGGAGLVPTLAAIRSGKHIALANKEPMVMAGQLMQEEARRHKVKIFPVDSEHSAIFQSLEGHRIEDVRRLILTASGGALWTLTKAQLQEVTPEQALQHPNWKMGAKITIDSATLMNKGLEVVEARWLFDIPESRIDVLVHRESIIHSLVEYEDRSMIAQLGLPDMRTPISYAMHYPERLALDLPSLDLTEVGKLSFCKPDHDRFPCLRLGYESLRIGGTMPAAMNAANEIAVEAFLNGGIKFPAIADIIRQTMDAHQRREIDRIETALEADRWAREKAESLAGSLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I713</accession>
    <name>A0A1W1I713_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">(Glutamate-ammonia-ligase) adenylyltransferase, subunit B</fullName>
            <ecNumber evidence="6">2.7.7.42</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glnEb</name>
        <name evidence="6" type="ORF">NSJP_2431</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.42" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2431"/>
    <dbReference type="EnsemblBacteria" id="SLM48603">
        <property type="protein sequence ID" value="SLM48603"/>
        <property type="gene ID" value="NSJP_2431"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2431"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008882">
        <property type="term" value="F:[glutamate-ammonia-ligase] adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023057">
        <property type="entry name" value="GlnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005190">
        <property type="entry name" value="GlnE_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30621">
        <property type="entry name" value="PTHR30621"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03710">
        <property type="entry name" value="GlnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GlnE" evidence="4">
        <location>
            <begin position="121"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="GlnD_UR_UTase" evidence="5">
        <location>
            <begin position="409"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="576" mass="64429" checksum="F3D0A447B8B63CC4" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I727</accession>
    <name>A0A1W1I727_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48804">
        <property type="protein sequence ID" value="SLM48804"/>
        <property type="gene ID" value="NSJP_2637"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2637"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="337" mass="37527" checksum="BBC809A6EFB3CB60" modified="2017-06-07" version="1">MLGWSRPDPLTRDLIHLINARRHDHGDTDAAIDTLQAFLEQGREHDLLTVLAALDEDMAEWLFDLVAEASCAILMDGPADEKLSYAVMAALELPLQANLTHPLKLKIDPVATAELLHRHLRLPSASVVRVEARLLTDSTLEPLSLQSLNEHLSTVADSQRVHSIAARLYPPVENTAFLLFELIGVPDAGLPDSLEDPHRRALLEGLVEQCPELAHAPDSIEAPVYAAYAMFDAQNAVRLHRLADETAAVWRDLDPLVRARTIVHLHTQCGNGVYMPVWTDLFDPELPEEHGPVWTSPDVWVFTADLPIEWPGEMLTNRLLAEGCTRFENHIVEAPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I750</accession>
    <name>A0A1W1I750_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative DNA-binding response regulator in two-component system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yfhA</name>
        <name evidence="10" type="ORF">NSJP_2685</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2685"/>
    <dbReference type="EnsemblBacteria" id="SLM48852">
        <property type="protein sequence ID" value="SLM48852"/>
        <property type="gene ID" value="NSJP_2685"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2685"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="8">
        <location>
            <begin position="144"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM48852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="472" mass="52245" checksum="5C8C920AA5495E18" modified="2017-06-07" version="1">MEQEHILVVDDEEGLLQLVKMRLQAMGFAVTACTTGRDAVSAAKVNRFDLAITDLRLGGEDGLDVTEELLRIHPGLPVIILTAHGSIPNAVEAVQRGAFGYLTKPFDDKELKAKIEEGLSPQRMSREIQRLKSLVNELYGMENVVARSPAMQRLLQQVVQVADSDATMLLFGETGTGKEVFARVTHANSRRSKGPFVALNCAAIPETLFESELFGHVKGAFTSAHGPKKGLFQSAHGGTLFLDEIGEMPLSMQVKLLRAVQEREVREVGAEHATKVDVRIIAATNKDLDEAVKNGTFRNDLYYRISVVPLFIPPLRDRREDIPIMAQQFLALSAKRANKDMRGFTPAALHRLVTNLWPGNVRELENAIEKAVVMARQDMVTPDLLPSTGSAPDAQLKPLTEAKEEFEKTYLKNVLQLTGGNISRAAQFAGRYRADFYKMLKKYGLHPSMTKGKAAPEVEELEEESDLTEAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I792</accession>
    <name>A0A1W1I792_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Dioxygenase, ferredoxin subunit, and Flavodoxin (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_2572</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2572"/>
    <dbReference type="EnsemblBacteria" id="SLM48739">
        <property type="protein sequence ID" value="SLM48739"/>
        <property type="gene ID" value="NSJP_2572"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2572"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="6"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="368" mass="41148" checksum="C9990859FDB5C0B1" modified="2017-06-07" version="1">MAENRWVDVGTVEELKKTPLQEVMCGTTPIALSYKDGVFSAISGVCNHVGGPLGEGTLEGDYVVCPWHYWKFHRQTGRGEAGYEQDQVPTYATRVDNGRLFIDRSSATKRHKQLHAPHPLARPIVRQDGPIRVVGISTTTMTQDHPRFSTSDALLDVALEYARTTLGLEAQCIKLRELNFRPCEGFYSKSALACTWPCSITQMDPNDQLDRVYEAIVHWADVILISTPIRWGNASSLYYKMVERMNCIQNQETIANKHLLKNKVAAFIIMGGQDNVQGVAGQLMTFFSEVGCQFPQFPFIAHSRGWSAEDMERNVSEVRHSQELREGAQELVTRAADMARLMVEGQVPARPLARGGRKAHQLDSEPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7I5</accession>
    <name>A0A1W1I7I5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein SrpI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">srpI</name>
        <name evidence="2" type="ORF">NSJP_2815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2815"/>
    <dbReference type="EnsemblBacteria" id="SLM48982">
        <property type="protein sequence ID" value="SLM48982"/>
        <property type="gene ID" value="NSJP_2815"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2815"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045641">
        <property type="entry name" value="MmpI-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19307">
        <property type="entry name" value="PCLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCLP" evidence="1">
        <location>
            <begin position="65"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="324" mass="36189" checksum="54B06C4A5DB4D365" modified="2017-06-07" version="1">MSDSRTAHDSRTSLSAQAARNLATATVTVPQMTEITPRWLHKLLPWVDVDGGVYRLNRVAKAPKGRPANEFGEVKVDLLTVDSGEPRLPATFVDYELHPREYHLSTIQTIVHTHTRVTDLYSNRVDQLREQVRLTIEAVKEREEWELLNHGQFGLLKEVSAGQRIETRKGTPTPDDLDELLTLVWKKPAFFLAHPKAIAAFGREATRRGVPPPTVHLFGSPFITWRGIPLIPTNKLDIDRAGKTTILLLRVGETHQGVVGLQKAGVAGELEPGLSVRYMGTNEHGIASHLVTRYFSVAVSTEDAIARLDNVSVKFYHDYVYPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7K7</accession>
    <name>A0A1W1I7K7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48911">
        <property type="protein sequence ID" value="SLM48911"/>
        <property type="gene ID" value="NSJP_2744"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2744"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="320" mass="34810" checksum="C26F0ABD61EA1F47" modified="2017-06-07" version="1">MQLAGWPLVGVLLSAGFSGWEPASSPPVHPASSTGQLTGDELLRIGEIHDHQHHFRETLTYYHLALAQFRKAKQPGGIAASLVKIALVHERQGKLQEAYAELQEATSLYARTADRPAQASAWLAMGRIAAGLGQTDVARDALRQAAALFDRAKDRRGTTDAAIRLGLLEVADGQVEPGLALLRRALADAHARQDSSQQLSATVALGDARWLLDQESEARSQYEAGLELARTERDMAMEASLRLKLAYMDDASGRVKEAIESSKQAIFLSQTLRDPLTEAKALSLLSGLYRQTGESAEADAAEQRALSIYRHRQLFVHGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7L0</accession>
    <name>A0A1W1I7L0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48793">
        <property type="protein sequence ID" value="SLM48793"/>
        <property type="gene ID" value="NSJP_2626"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2626"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="155" mass="17376" checksum="5D4BCF8BC89721B5" modified="2017-06-07" version="1">MPLDAELGKKMLQLVTSRYDDRHWRKKIEKTLSLPQSGVSDPTQQQIFMYLKVGLKAYKSRRADPDSWIIGGFATKEVVDRAKFQPQLVDSTVTKDDVSFLGSDPGPEVDEAWWDEMLVQWFDVPEEEKPAEGEGEDQAAESTSAGVPEGKSAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7L1</accession>
    <name>A0A1W1I7L1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48996">
        <property type="protein sequence ID" value="SLM48996"/>
        <property type="gene ID" value="NSJP_2829"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2829"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018743">
        <property type="entry name" value="DUF2292"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10055">
        <property type="entry name" value="DUF2292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="61" mass="7026" checksum="A8555B173E004FDE" modified="2017-06-07" version="1">MRSLSNSTELSDHNVHRQVEQAIIHALKGIRFGSVEIIVHDSKVVQIERKEKTRFDADLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7L4</accession>
    <name>A0A1W1I7L4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_2808</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2808"/>
    <dbReference type="EnsemblBacteria" id="SLM48975">
        <property type="protein sequence ID" value="SLM48975"/>
        <property type="gene ID" value="NSJP_2808"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2808"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="228"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="296"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="510" mass="56750" checksum="5DD54CA2EA7076A0" modified="2017-06-07" version="1">MQHRWIGRLSIGQKFLLSFGLILSLLALSLTALLFYLSRINSYVDRHKRITVPAIVTAAAMQRDAYDLKLVLHLHVERNSVDSLADTLVEVDRHTTDIRNALNLYKRTHAARTHPILYGMLEEHQRIDLADREDRAIENIAESLAELTDAWKRLPAQPPPTRPDMALTDRLMTTVLGGLDQLVEAHTQIDIEMKHEGDRLLGRARFIALALALLLGLVIAATYVLATRYIARPLTTLAATADQVAHHDLTARFAPWPSRDEVGTLAGSLTTMLASLREQSAALMRKTKELEAFTYSIAHDLKGPLREIEGFSSLLEKQFADSSDEQANHHIGVIRSSAIRLTHMIDALLKYSRLEQQELPKQRFNVRDMIDNVVNDRVASGVISPNSVHIALPFSELYGEPVSVRQALVNLFDNAVKFSRGSPDPSIRIEGTDEPAQRVIRITDNGIGIEADQVGKIFGLFERLHGPQEYEGTGVGLAIVKLVMEKHQGQAWAESTPGAGSAFYLAFPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7M5</accession>
    <name>A0A1W1I7M5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49048">
        <property type="protein sequence ID" value="SLM49048"/>
        <property type="gene ID" value="NSJP_2881"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2881"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="182" mass="21374" checksum="57B874FB972420DB" modified="2017-06-07" version="1">MIRLVHRPELLGFRIRELHVARDQQLLVRLELLLQDLHIRVRLCVRRKHRNGHQHGSSQHHRHHFVHEGILSEMGVMERWAGTNSTLISVRHRAGITLNEALIYHTLITLTKWQKLSKLTGGPRGESSTSQYLNHKTQALAPNSHGQTRNSKSEIRNSKPQEMRLWDFWFRISCFEFSCRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7P5</accession>
    <name>A0A1W1I7P5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gly-zipper_Omp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2901"/>
    <dbReference type="EnsemblBacteria" id="SLM49068">
        <property type="protein sequence ID" value="SLM49068"/>
        <property type="gene ID" value="NSJP_2901"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2901"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039567">
        <property type="entry name" value="Gly-zipper"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13488">
        <property type="entry name" value="Gly-zipper_Omp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012009135" description="Gly-zipper_Omp domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Gly-zipper_Omp" evidence="2">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="155" mass="16211" checksum="7D3895726E5BC114" modified="2017-06-07" version="1">MLYTFSVIVMMVVALLAGEASAGLDVFVYPSKGQSKDQQEQDEFACYKWSKEQTGFDPTQTVQQAAPPQQHGQVVHGAARGAALGAVGGAIAGDAGKGAAIGAAVGGTGGAMRRRRQARETEMAQQQAEQKYEASVAGYKRAFTACMTGRGYTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I880</accession>
    <name>A0A1W1I880_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49195">
        <property type="protein sequence ID" value="SLM49195"/>
        <property type="gene ID" value="NSJP_3028"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3028"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="124" mass="13250" checksum="9077F8D178C31E55" modified="2017-06-07" version="1">MRSESPDQKTEGLMQGLLVVMMTVGLAVGPSVAHAAEQRVDAPQSSLQNLSPASPAPPYTEDALSGTIRPQQPDENPDCDDARPSTARPRTMLSRFARLSTTTSDVQCPIPTVADPSTQQELHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I897</accession>
    <name>A0A1W1I897_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3075"/>
    <dbReference type="EnsemblBacteria" id="SLM49242">
        <property type="protein sequence ID" value="SLM49242"/>
        <property type="gene ID" value="NSJP_3075"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3075"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010708">
        <property type="entry name" value="5'(3')-deoxyribonucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06941">
        <property type="entry name" value="NT5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="421" mass="47852" checksum="F1798E4A37D32BD1" modified="2017-06-07" version="1">MTDFHKRISDQLVRLIQIVFGLVLAQSLLLYKEVILHPLHESHWISLLALSTVFITTIMSWIDWHITMELRPYNFDYKNERRRSEEIRLGVDMITVILYAYLLFSIQSIVNGPSQSIAGYLTGFLLVFIAYLLSGLARRHAHGPLASNPVPIIRFGAIYALLLIVYQVVFNRISTSSSSGTYVLNAVTVVVTLAVMVSYRIVRRSAGKMRQQEKDKGFKLGIDIDGVLANQIHGVLPRIKARSGISLRYDEISEWRLTVGDSDIAREIEAALTDDEYVLNMPVHKGARAMSDKLYERNRIILLTARPSASRAATKQWLSSKGFSYDELVNAKEQKKSFYGVDVLVDDYIQNILDYLQNSNGLAILVSQPWNQDRTALKPWLSTRRLFIVNDLSRVSEIISDRPELSTLNLRQQLTAGFVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8E9</accession>
    <name>A0A1W1I8E9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin synthase sulfurylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">moeB</name>
        <name evidence="2" type="ORF">NSJP_3098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3098"/>
    <dbReference type="EnsemblBacteria" id="SLM49265">
        <property type="protein sequence ID" value="SLM49265"/>
        <property type="gene ID" value="NSJP_3098"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3098"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="11"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="267" mass="28688" checksum="E4171A90F9E9CD58" modified="2017-06-07" version="1">MELTEQQVQRYSRHIILQEVGGKGQLKLNSAKVLLIGAGGLGSPAALYLAAAGIGTIGLVDGDVVDLSNLQRQILHSTASLGQPKVESGRNTLAAINPEITIKTYHQLVDADNILPLIKEYDIVLDGSDNFATRFLVNDACFFAKRTLISASMFRFEGQLTTIKPHAGYPCYRCLYPEPPPAGLVPNCQEAGVLGVLAGTMGVLQASEAIKEILGIGETIADRLLIYDALDMKFRKVGRPKDPACRLCGPTPSITDLSTDYTVTCTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Q3</accession>
    <name>A0A1W1I8Q3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lpd</name>
        <name evidence="16" type="ORF">NSJP_3230</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3230"/>
    <dbReference type="EnsemblBacteria" id="SLM49397">
        <property type="protein sequence ID" value="SLM49397"/>
        <property type="gene ID" value="NSJP_3230"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3230"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="7"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="346"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="318"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SLM49397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="469" mass="49332" checksum="128148A7D0B46A06" modified="2017-06-07" version="1">MAETECDVVVIGAGPGGYAAAFQAADLGLRTVVVDQEAQPGGVCLLRGCIPSKALLHAARVISEAEDARAWGIEFDKPRVDLETLRRRVKTIIAKLTKGVQALAGSRKVELIQARATFKDKTTLSLNGSGGSRELTFAHAILATGSRPVVPGSLAIDDPRVMDSTGALDLPDVPARLLVVGGGYIGLELGTVYHALRSEVTVVEALPRLLNGADLDLIRPLQQRMERRFKAIKLETKVDKLESRKDGIAATLAGSGGSTTEVFDRVLVAVGRRPNTEQLGLETTKVALTAKGFVQVDRQLRTAEPAIFAIGDVAGEPMLAHKATHEGLIAARVIAGQQTAFDATAVPAVVFTDPEIAWCGLTEEAAKAAGQAVTVTKFPWLASGRATTLGRNDGLTKLILDKESGRVLGVGICGVGAGELIAEGVLAVEMGAVAEDVAASIHPHPTLSETVMEAAEAFHGYPTHLYSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8S7</accession>
    <name>A0A1W1I8S7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3255"/>
    <dbReference type="EnsemblBacteria" id="SLM49422">
        <property type="protein sequence ID" value="SLM49422"/>
        <property type="gene ID" value="NSJP_3255"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3255"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="181" mass="20105" checksum="66C74EBC0E5845D3" modified="2017-06-07" version="1">MIPLQGNRLTSKAREAFGLHSLGWSSFQQLCLTITREVLGQTVESFLDSGDGGRDGAFVGTWKTARQEHLSGPFVVQCKFTSKINFTLKASDLFDEAKKVKKLVTRGLCDSYVLMTNAEISGTGAEKIQSVFKAVGVKHVVTFGSTWINQQIRESKRLRMLVPRVYGLGDLSQILDERAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Y6</accession>
    <name>A0A1W1I8Y6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49391">
        <property type="protein sequence ID" value="SLM49391"/>
        <property type="gene ID" value="NSJP_3224"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3224"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="154" mass="17526" checksum="D6BBF7D34FEB4819" modified="2017-06-07" version="1">MRNALMARRWGWGIVIGLWGVLLYGCTTPEQPPTLLAPTEAQLKIRNFQTRVFDMTDRNFAIRSVIGSLQDLGFIIERANDVLGLVTAARFAEPNYYDVVTITVTVRQLNATQLTIRANAIYNNRPIEDPKVYQNFFFTLERSLFITKESPTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I949</accession>
    <name>A0A1W1I949_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3367"/>
    <dbReference type="EnsemblBacteria" id="SLM49534">
        <property type="protein sequence ID" value="SLM49534"/>
        <property type="gene ID" value="NSJP_3367"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3367"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="293" mass="32237" checksum="5FBB61F29FD2ABD2" modified="2017-06-07" version="1">MSCSHNPPLIMARPRHFSHFPMYRLISALVLAITLLVVIGCATGRAKDAPPLKQATAEELTALLKQREAALQSLKGLFSAKVRGGILPITTRVEGTLYYERPNALRLRGFTPIGGELFEFLQSDDQFTLRLPTMGRVLSGNGSDTGEMGKLARPFQLSVWAMSGVLGTDAVAPFETVTLSEDGDRYRLDVFGPLTNGGNGLRRRLWFDRQRLLVVQAERLTDSGNIDASIRYDDFRPVGTDAVPVSSPDSAQDRMLRPFKISLEDGRGEGSVQIMFHELIPNQPLKPSDLGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I971</accession>
    <name>A0A1W1I971_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Peptidase M22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3368"/>
    <dbReference type="EnsemblBacteria" id="SLM49535">
        <property type="protein sequence ID" value="SLM49535"/>
        <property type="gene ID" value="NSJP_3368"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3368"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="30"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="250" mass="26895" checksum="D77BBC29D2B8CD7B" modified="2017-06-07" version="1">MKILAVDTATAWQSVALLDDATVLALEEQEARGSHTRLLLPAIRRLFARTGLSLARLDGLAVSAGPGSFTGLRVGLATLLGFRTISGLPLAVVPTLEGMAWNFHGTDVPLCPIVNSRRGEVYWALFRWHGDRLERLAAERAGTAAQLAATLSGRTMLYGEGWTTEGEAIRAACTGKLRALIETPDRNQTPSAVSVGYAGIDKLRRGERAGLGVSPLYVQRPEAEVKYDESGGLSPLARRRAKLARKLAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9F3</accession>
    <name>A0A1W1I9F3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 3</fullName>
            <shortName evidence="5">RF-3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">prfC</name>
        <name evidence="7" type="ORF">NSJP_3500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3500"/>
    <dbReference type="EnsemblBacteria" id="SLM49667">
        <property type="protein sequence ID" value="SLM49667"/>
        <property type="gene ID" value="NSJP_3500"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3500"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04169">
        <property type="entry name" value="RF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00072">
        <property type="entry name" value="Rel_fac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004548">
        <property type="entry name" value="PrfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032090">
        <property type="entry name" value="RF3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038467">
        <property type="entry name" value="RF3_dom_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041732">
        <property type="entry name" value="RF3_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43556">
        <property type="entry name" value="PTHR43556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16658">
        <property type="entry name" value="RF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00503">
        <property type="entry name" value="prfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="22"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="99"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="540" mass="59648" checksum="2A15366179F62C16" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9F8</accession>
    <name>A0A1W1I9F8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Formate hydrogenlyase, membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3394"/>
    <dbReference type="EnsemblBacteria" id="SLM49561">
        <property type="protein sequence ID" value="SLM49561"/>
        <property type="gene ID" value="NSJP_3394"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3394"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="320" mass="33895" checksum="2A4BAD887C87CD57" modified="2017-06-07" version="1">MSIPTILQAIALSVAQAIILSILAPFIVGLIRKLKARLQCRRGPSLFQPYADLAKLFRKQPVVSTTASWIFTATPYIVFGSTLTAGLLVPVFVSQVPLGFAGNIIALVYLFALGTFFLILAGLDAGSAFGGMGGSREAIVASLTEPATIMSIFAIALTAGSTNLSTIVHRTALLEGATDPVPHLMALAALFIVTLAETGRVPVDNPTTHLELTMIHEAMILEYSGRYLALLEWAAAIKLLVFLTLIANVFAPWGIATSPTPPALAIGVAVYVAKVSVLAASIGLIECLFAKLRLFRVTDLLGVAFILALLGLLFFYILQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9P6</accession>
    <name>A0A1W1I9P6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HNH endonuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3601"/>
    <dbReference type="EnsemblBacteria" id="SLM49768">
        <property type="protein sequence ID" value="SLM49768"/>
        <property type="gene ID" value="NSJP_3601"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3601"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
        <property type="entry name" value="HNH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="71"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="181" mass="21257" checksum="3F59F2B7FA59A580" modified="2017-06-07" version="1">MEMTLLLNSTYEPLRVVHWQKAIALLWQGKVEVLEVYDREVHGVSISFKLPSVMRLLKLVRLKDSHRAVKFSRINIFTRDGYTCQYCRSKYRTEELTFDHVVPIAKGGRKTWENIVTACWRCNNRKSGRTPDEAGMRLMKRPVKPRWSPIVTITIGIRNTPESWRDYLYWNMELDADPSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9R6</accession>
    <name>A0A1W1I9R6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase, family 2</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3621</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3621"/>
    <dbReference type="EnsemblBacteria" id="SLM49788">
        <property type="protein sequence ID" value="SLM49788"/>
        <property type="gene ID" value="NSJP_3621"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3621"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031725">
        <property type="entry name" value="ASMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16864">
        <property type="entry name" value="Dimerisation2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dimerisation2" evidence="5">
        <location>
            <begin position="17"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_2" evidence="4">
        <location>
            <begin position="116"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="342" mass="36612" checksum="D649C67E820A4013" modified="2017-06-07" version="1">MPATSVSHAAIPPHAQLVQMATAHWVSHILYVAAKLSLADHLASGPKRVDELATATKTHAHSLGRLLRTLAHLGLVTEHGTQFTLTPLGEALKTGAPGGARSATLTLASPWMTGGWERLMESVQTGRSGLEQALGMPIFDWLAQHPDEASLFSETMVSFHGAEPAAVAAAYDFANMTAIVDVGGATGNLLAAILDKYHGSRGILYDLPHVVRDAPKLIQARGLADRVTVMPGSFFERVPEGGDAYLLSHIIHDWSEEQCLTILGHCRRVMKPTARVLIIEMVLPAGNVQHPGKMLDMMMLVGPGGQERTEPEYGTLLNKAGLRLTKVVPTDSAVSVVEAMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9S5</accession>
    <name>A0A1W1I9S5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 17" type="primary">dnaG</name>
        <name evidence="17" type="ORF">NSJP_3462</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3462"/>
    <dbReference type="EnsemblBacteria" id="SLM49629">
        <property type="protein sequence ID" value="SLM49629"/>
        <property type="gene ID" value="NSJP_3462"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3462"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="16">
        <location>
            <begin position="259"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SLM49629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="601" mass="66690" checksum="DA6B19B21A5138F0" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9T3</accession>
    <name>A0A1W1I9T3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">argJ</name>
        <name evidence="8" type="ORF">NSJP_3589</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3589"/>
    <dbReference type="EnsemblBacteria" id="SLM49756">
        <property type="protein sequence ID" value="SLM49756"/>
        <property type="gene ID" value="NSJP_3589"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3589"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023556420" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023556419" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="193"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="192"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="407" mass="42871" checksum="3AD3EA0151AEE00A" modified="2017-06-07" version="1">MSTETAKSKHSQGVTAPKGFRAAGIHCGIKKPGLLDLALVVSDRPGPIAGVFTNNQVVAAPVVLDRQHLRNGVGRAILINSGNANACTGPAGLAAARRTAAALAKRLNGPLHEAFIGSTGVIGRRLPVERILRSLPELVRQLSPRGGLSAAKAIMTTDLRPKSAALRADINGAVVTIGGMAKGSGMIHPNMATMLGYLTTDAAIASRTLQTALIEAVNASFNCISVDGDTSTNDTVLCLANGLADNRVIREGTAGYRRFTDLLTEACRTLALAICRDGEGVTKVVKIEVAGARTVEEARQVARTIGTSNLVKTAFFGEDANWGRVMAAVGRSGVPIVPSKIALSFDGIAMVSKGVGLGLAAERRIARVFRRKEFTVRVELGQGRHEAQLWTTDLSFDYVRINASYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA55</accession>
    <name>A0A1W1IA55_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49904">
        <property type="protein sequence ID" value="SLM49904"/>
        <property type="gene ID" value="NSJP_3737"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3737"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="7"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="213" mass="23449" checksum="9A57D53C6A413A48" modified="2017-06-07" version="1">MAQLIICFGDSLTAGFQSPTRTHPTGRDTPYGEFLQGWLGASSQVRVSGNCGELTSEMAMRFRQDVLAHRPGYVVILGGTNDLGWNAKPSDIMRNLLTMYELSRAEQIIPVPVTVPSVRIEDAGGAPDAAAWIEDHLQRRRQLNELILAYAHSKQLIAVDLFTETAEPDTGRLAASYSNDGLHLTTAGYRRFAELLFDRVFQRVCPDAPGRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA63</accession>
    <name>A0A1W1IA63_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3770"/>
    <dbReference type="EnsemblBacteria" id="SLM49937">
        <property type="protein sequence ID" value="SLM49937"/>
        <property type="gene ID" value="NSJP_3770"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3770"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="213" mass="25113" checksum="0581F6490104EA86" modified="2017-06-07" version="1">MSAKTKSKRPPLTANISIDEFRAFYWYLHELVEFCRNNGLPTGGQKLAVVSRIERFIRSGKRTGLAESTSIKRRVSTAPRELSILTVVGNDFKCDVTARNFFKSVIGEHFHFTAHVNRFRRERLRRGIRTTYGDLAREWLAEHERRKDPRYKSKIERSWQYNQFVRDFAADKLRNRGKGMRGAAKAWNEIREHRGPHTYAEYVRITERRQPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAF9</accession>
    <name>A0A1W1IAF9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49859">
        <property type="protein sequence ID" value="SLM49859"/>
        <property type="gene ID" value="NSJP_3692"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3692"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="111" mass="11699" checksum="7A8F8BBCA384B016" modified="2017-06-07" version="1">MKIGAIVLMLAVVFFPALSDARCRTVGESASLGSEYGTFPLYPAEAVVETGAKRESVPLQWVGYGIGLPLFVVALPFGMLGAGVGAALHPWTKCAETEGRLPMTEGQALTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAG1</accession>
    <name>A0A1W1IAG1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3813</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49980">
        <property type="protein sequence ID" value="SLM49980"/>
        <property type="gene ID" value="NSJP_3813"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3813"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10147">
        <property type="entry name" value="Wzt_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029439">
        <property type="entry name" value="Wzt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14524">
        <property type="entry name" value="Wzt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="42"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="80"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="450" mass="49731" checksum="A592BD5EDD88F52A" modified="2017-06-07" version="1">MGVIAIKAEALSKQYRLGSAAQSYQSLRDVIMQVATYPLRTVRGLGNGRLKGSGDPEPSLWAAKDISFEIQHGEIVGIIGRNGAGKSTLLKLLSRITEPSSGWVELRGRIGTLLEVGTGFHPELTGRENVFLNGAILGMGMTEIRRKFDDIVTFAEVEKFIDTPVKHYSTGMAVRLGFSVAAHLEPDILLIDEVLAVGDAGFQKKCLGTMGALREKGRTVLFVSHNLAAIENHCSRTIWIDEGRIREDGRTSDVVKKYLASFGSEQDAYKDLRTMERQKAGGAIRYTGLEFLNGHSGQEIVRTGERMALRLHYTVTEPVSYPYFGVEIYNELGTMIASLNTWSSGYEVPLLSPGDGFIDLEVDSLTLMPSQYYLSVWLAGVGPRWHDKIDRCASFDVEARDYYGSGRGVERKFGLVVFPCRWGPLGDGHEHTNELETQVSNTDCQPDILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAN1</accession>
    <name>A0A1W1IAN1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ferrichrome iron receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fhuA</name>
        <name evidence="11" type="ORF">NSJP_3941</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3941"/>
    <dbReference type="EnsemblBacteria" id="SLM50108">
        <property type="protein sequence ID" value="SLM50108"/>
        <property type="gene ID" value="NSJP_3941"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3941"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030148">
        <property type="entry name" value="Fiu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF68">
        <property type="entry name" value="PTHR32552:SF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07660">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0798">TonB box</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012732217" evidence="9">
        <location>
            <begin position="27"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="STN" evidence="10">
        <location>
            <begin position="51"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM50108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="834" mass="92113" checksum="194FF1C954395D70" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAP0</accession>
    <name>A0A1W1IAP0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3893"/>
    <dbReference type="EnsemblBacteria" id="SLM50060">
        <property type="protein sequence ID" value="SLM50060"/>
        <property type="gene ID" value="NSJP_3893"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3893"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007844">
        <property type="entry name" value="AsmA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032712">
        <property type="entry name" value="AsmA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05170">
        <property type="entry name" value="AsmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13502">
        <property type="entry name" value="AsmA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsmA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="AsmA_2" evidence="2">
        <location>
            <begin position="834"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1114" mass="121050" checksum="A8A49624E871400D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAP3</accession>
    <name>A0A1W1IAP3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FG-GAP repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3812"/>
    <dbReference type="EnsemblBacteria" id="SLM49979">
        <property type="protein sequence ID" value="SLM49979"/>
        <property type="gene ID" value="NSJP_3812"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3812"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="792" mass="88075" checksum="2DA2270676510C84" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAP4</accession>
    <name>A0A1W1IAP4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Polysaccharide export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3824</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3824"/>
    <dbReference type="EnsemblBacteria" id="SLM49991">
        <property type="protein sequence ID" value="SLM49991"/>
        <property type="gene ID" value="NSJP_3824"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3824"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012122243" evidence="2">
        <location>
            <begin position="32"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="123"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="208" mass="22502" checksum="D5A1D76DC1BFA48A" modified="2017-06-07" version="1">MHEMIRRGICLRAVILLAAVAASFGGVPGCAQPTIQEREYDAPQQFLLGPEDVVEIAVWKNLELTKTLAIRPDGAISMPIIGEVQAAGLTTDALAQRVTERLKPFIANPSVSVSVKDLNSYAVFVVGEVTKPGKYQLKSYATVLQAISLAGGFTDFAKKNKMQVVRLKSNGDQKLREIHIPVRYDDVVAGRIESGNMILLSGDTVVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAT5</accession>
    <name>A0A1W1IAT5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50009">
        <property type="protein sequence ID" value="SLM50009"/>
        <property type="gene ID" value="NSJP_3842"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3842"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="64" mass="7318" checksum="2A66E0CEB9945FE1" modified="2017-06-07" version="1">MQYWVKVVFVDNQELVVKDAIRHTISDDMEVLEVDSAKEVVIIPMKQIKYVACDATVFATKSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB34</accession>
    <name>A0A1W1IB34_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5672 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50216">
        <property type="protein sequence ID" value="SLM50216"/>
        <property type="gene ID" value="NSJP_4049"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4049"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043729">
        <property type="entry name" value="DUF5672"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18922">
        <property type="entry name" value="DUF5672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5672" evidence="1">
        <location>
            <begin position="63"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="281" mass="33527" checksum="1F33E5C03E2C043D" modified="2017-06-07" version="1">MHFGQPFGDQEKRKVAVVIPLSNRSTFTVDEEISYKQLVHFLGKYDRYFVTPKSLDIDFPESRIRRFDDRYFGSIVAHTKLMLSAMFYDSFSDYEYILIHHLDALVFSDQLLKWCEEGFDYIGPPWIKCDATPWVEVSRVGNGGLSLRKIKSFLRVFDSDRHWVDPDEYWEGFCRAHPLPTQLLNLPRKFLKRLVYFNNVKHELAQWPFRTDGKGNEDYFWADEATRYYPPFNVAPFKVGLRFAFEVAPRLCYQMNNYQLPFGCHAWPRYDRAFWEPYLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB67</accession>
    <name>A0A1W1IB67_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-D-QuiNAc alpha-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4130"/>
    <dbReference type="EnsemblBacteria" id="SLM50297">
        <property type="protein sequence ID" value="SLM50297"/>
        <property type="gene ID" value="NSJP_4130"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4130"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13477">
        <property type="entry name" value="Glyco_trans_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="383" mass="42295" checksum="2DFD5A3369BDD0A1" modified="2017-06-07" version="1">MNARPRLLYLITEDWYFWSHRLDLARAAVASGFDVALATRVTDHETRILKEGVRLFPIRLSRRSKNPLAELLALAELTRLYKRERPAVVHHVGLKPILYGSIAARLASVPTVVNAFAGLGYLFTDEDRQGRFLNKTLGRVLRAVLTSVRSTVIFQNHDDRDLLIKERVVTREQSRIIPGSGVDVSTFTLRPPSGEGPIVMLASRMLWDKGIGEFIEAVRRLKSNGVSARFVLVGRCDEHNPAAILEETVRSWAEEGLVEWWGHREDMPATLALATIAVLPSYREGLPKSLLEAAACGKPMVATDVPGCREILVHGVTGLLVPPKDSAALAAAIHSLLDDPALRTEMGVAARELVVRSFSVETVTEQVIRLYRELLAGKPPGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBB0</accession>
    <name>A0A1W1IBB0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4151"/>
    <dbReference type="EnsemblBacteria" id="SLM50318">
        <property type="protein sequence ID" value="SLM50318"/>
        <property type="gene ID" value="NSJP_4151"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4151"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="859" mass="96962" checksum="F228F74F828EC552" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBC4</accession>
    <name>A0A1W1IBC4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_4135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4135"/>
    <dbReference type="EnsemblBacteria" id="SLM50302">
        <property type="protein sequence ID" value="SLM50302"/>
        <property type="gene ID" value="NSJP_4135"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4135"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="396" mass="43984" checksum="CFB90B45AC5ECF50" modified="2017-06-07" version="1">MEIAPAPIRVLHCPDLVGGQPYQLAKAERAIGLKSQCVALQPHPFGYPADRVLSSGGEAALQLARWRLLAMALRHYDVIHFNFGQSAMPQRLPLDAASKRNLPSWTRRLYNLYAAPLELADLRLLKLNGKSIVMTYQGDDARQGDFLRAHCEIHPADEAGYYTAESDRLKRARIETVGRYADAVFAVNPDLLHVLPARARFMPYAHLDVAAITPPGGTTRAVPMVLHAPSHRGVKGTRFVLDAVNRLKSEGVPFEFVLVEGLSHVEAMRLYAGADLLIDQLLVGWYGGLAVELMALGKPVVAYIRDRDLHFIPPAMRAELPVVNATPDSITRVLRELLTVRRHELGELGMRSRRYAEVWHDPARIASHLKSTYQNLINQSHGGRAAETATVRQDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBD5</accession>
    <name>A0A1W1IBD5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Asparagine synthetase [glutamine-hydrolyzing] 1</fullName>
            <ecNumber evidence="9">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_4149</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50316">
        <property type="protein sequence ID" value="SLM50316"/>
        <property type="gene ID" value="NSJP_4149"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4149"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="373"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM50316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="618" mass="69754" checksum="471786697B80C5B7" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBI4</accession>
    <name>A0A1W1IBI4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_4104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50271">
        <property type="protein sequence ID" value="SLM50271"/>
        <property type="gene ID" value="NSJP_4104"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4104"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013094115" evidence="1">
        <location>
            <begin position="30"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="2">
        <location>
            <begin position="305"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="807" mass="89227" checksum="32488E682430EAA2" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBV0</accession>
    <name>A0A1W1IBV0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen synthase</fullName>
            <ecNumber evidence="7">2.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Starch [bacterial glycogen] synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">glgA</name>
        <name evidence="10" type="ORF">NSJP_4076</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Synthesizes alpha-1,4-glucan chains using ADP-glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4076"/>
    <dbReference type="EnsemblBacteria" id="SLM50243">
        <property type="protein sequence ID" value="SLM50243"/>
        <property type="gene ID" value="NSJP_4076"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4076"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 7 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_5" evidence="9">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="8">
        <location>
            <begin position="292"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ADP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM50243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="494" mass="54566" checksum="376E33F3B14D4814" modified="2017-06-07" version="1">MAASEAVPYAKTGGLADVAGALPSELAKLGHNVILVLPRYPSLDDSGRTFRVLERIPMYTSLGASEATIEEDVVSTPGQLPVRVWALRYDEFFGRSGLYQAQGKDFDDNLARFAWFSRGVIEVIRYLHRQKRWQTDILHLHDWQTALCAVYLKTLDSARPEVQTIKTVLTLHNVGYQGIFPSEKFWQTGLPQPLFRQEGLEFYGSVNLLKGGILFADRLTTVSPTYAREILTPEFGFGLQGVLQARREKLQGIINGIDVDVWNPETDPALPTRYSADKPTGKVQCKRALQKEFGLPSEDVPLLAVIARLTSQKGLDLVEEAIPRLMSLGLQLVVLGTGDPVHESNLAKIRDQFSSRMGLRIGFDEALAHQIEGGADIFLMPSRYEPCGLSQLYSLRYGTVPIVTKTGGLVDTVLPLGSDGKNSDTATGFHLLAPTADALVDAVREAIIAYARPALWSNMVQRGMKTDVSWARSARSYEELFISLLNATDQDRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZR1</accession>
    <name>A0A1W1HZR1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46235">
        <property type="protein sequence ID" value="SLM46235"/>
        <property type="gene ID" value="NSJP_0063"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0063"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="34" mass="3958" checksum="9EE3674824998722" modified="2017-06-07" version="1">MPVKSRDRREHFVDMPGTFRYGPEHESLSVLNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I024</accession>
    <name>A0A1W1I024_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0145"/>
    <dbReference type="EnsemblBacteria" id="SLM46317">
        <property type="protein sequence ID" value="SLM46317"/>
        <property type="gene ID" value="NSJP_0145"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0145"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="462" mass="49184" checksum="351EE5B14EF24CBC" modified="2017-06-07" version="1">MTDVVNRIWLAVALTIAVGIGPDRAVALAAVPGEIQRLYDKQQYQTVLDEIAKLDGAASSASDVRRLKVRSLLKLGNPKEALEEYDRLERVANQDETPLLRDVALGFITVMLKDMREQMRGAAFTALKEADSEELIPYFEDGLSDGSGPVRMLAVEGLSRTEAGRKSPKLRAALDDQAGLVKARVVKALGRSSDPSVVPLLEKASKDELPTVRIAAFGALLRHGRAEAWDALRRAADAVNPEDRAEAIRVMADVKDRRAVPIMLESLSYKQPSVRGAAARGLGHLGRREAREDIQRLLRDPVPAVREAAASALADLGDDASVPALDQALQDGVFSVRAASAAALLQLGQPFETVAPTIRGLTQQSDPGARTSAAHALGKASKGNVPGALSFLGNLSTDPLPGPKIVAVRSLGRIGDPSVLLLVKEALHDQNEAVRTTAGGAILRLLQGKRSSKSGFHPVVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I056</accession>
    <name>A0A1W1I056_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prokaryotic ubiquitin-like protein Pup</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Bacterial ubiquitin-like modifier</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pup</name>
        <name evidence="6" type="ORF">NSJP_0097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic ubiquitin-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0097"/>
    <dbReference type="EnsemblBacteria" id="SLM46269">
        <property type="protein sequence ID" value="SLM46269"/>
        <property type="gene ID" value="NSJP_0097"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0097"/>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008515">
        <property type="entry name" value="Ubiquitin-like_Pup"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05639">
        <property type="entry name" value="Pup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03687">
        <property type="entry name" value="pupylate_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="65" mass="7571" checksum="45243C9BAA9E9E31" modified="2017-06-07" version="1">MEKQERKQEQRKDPQAKEEVKANPKVVEAGKKLKEDIDKLVDEIDDVLEKNAEEFVKNYVQKGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I060</accession>
    <name>A0A1W1I060_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">rpsP</name>
        <name evidence="4" type="ORF">NSJP_0061</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0061"/>
    <dbReference type="EnsemblBacteria" id="SLM46233">
        <property type="protein sequence ID" value="SLM46233"/>
        <property type="gene ID" value="NSJP_0061"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0061"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_S16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="94" mass="10923" checksum="9F094AD6D8F95639" modified="2017-06-07" version="1">MAVHLRLTRTGRHKRPLYRVVAADSRKPRDGRFLEILGIFDPLKPAGLPELKQERVLRWLHQGAQPTVTVKTLLRRSGLWKQFETEKTAKKKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0G5</accession>
    <name>A0A1W1I0G5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Multidrug efflux system, subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mdtA</name>
        <name evidence="4" type="ORF">NSJP_0323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0323"/>
    <dbReference type="EnsemblBacteria" id="SLM46495">
        <property type="protein sequence ID" value="SLM46495"/>
        <property type="gene ID" value="NSJP_0323"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0323"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="79"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="405" mass="43758" checksum="4506B5E3A0C22ECA" modified="2017-06-07" version="1">MAEPIPFAAMLKRWLLGLAAACLLALAGYALLAKSGEEPSRAGQVPGGARAFPVLVVPARTGDIGVYLNGLGSVVPLNTVNVKSRVDGQLMRVLFQEGQLVREGDLLAQIDPRPFEVQLSQAEGQMARDRAQLKNAQLDLERYKGLVKQGYIPKQQLDTQEAMVRQLEGIVQADQSQIDNAKLQLAYSRITAPISGRVGLRLVDPGNMVRANDTSGLLVITQLTPITVVFTIPEDSLPPVLERLNAGRQLAVDAFDREQKKQLASGKLLTVDNQIDPNTGTVRLKAVFANEDGSLFPNQFVNARLLLDVKRGVTLVPSAAVQRGAKGTFVYVVKEDHTVAVRTVALGTTHGEDASIDSGLAAEELVVVDGTEKLREGSKVEVRNRNEPPANVSPPPGPEKPRRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0H2</accession>
    <name>A0A1W1I0H2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate synthase [NADPH] small chain</fullName>
            <ecNumber evidence="7">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gltD</name>
        <name evidence="7" type="ORF">NSJP_0207</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0207"/>
    <dbReference type="EnsemblBacteria" id="SLM46379">
        <property type="protein sequence ID" value="SLM46379"/>
        <property type="gene ID" value="NSJP_0207"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0207"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="6">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="147"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="477" mass="52039" checksum="2F5C60DBF279AF01" modified="2017-06-07" version="1">MGDPKGFMKYAREGPKRKPIELRVLDWKEMYEPIPEDKLKIQGARCMDCGVPFCQGGTGCPVVNLIPEWNDLVYRGRWKDALKALHTTNNFPEFTGRLCPAPCEGACVLGINEDPVSIRVIEWNIIDRGFNEGLVAPILPVVKTGKTVAIVGSGPAGLAAAQQLARAGHSVTLFEKADRIGGLLRYGIPDFKMEKWVIDRRLEQMKAEGVEFKTGVTVGKDITGEQLRKQFDAVGLTMGAEQARELPIPGRELKGVHLAMEYLTQQNKRTAGIAVSDEPITAKGKRVVIIGGGDTGSDCLGTAHRQGCVEAHQFELLSEPPPQRASSTPWPLWPMQLRTSHAHEEGCNRQWSVSTTKFTGHNGHITKLHGHRVKFEGGKFVPMPNTEFEMDADLVLLAMGFTGPVKNGLLDSLGVAYDQRGAVTTDDNFMTNLDGVFAGGDTKRGASLIVWAIAEGRKMAAGIDRFLQAGKSAKTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0I4</accession>
    <name>A0A1W1I0I4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glyco_hydro_63 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0346</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0346"/>
    <dbReference type="EnsemblBacteria" id="SLM46518">
        <property type="protein sequence ID" value="SLM46518"/>
        <property type="gene ID" value="NSJP_0346"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0346"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="PTHR10412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_63" evidence="3">
        <location>
            <begin position="571"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="892" mass="103789" checksum="667DD733466F5DE3" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0I9</accession>
    <name>A0A1W1I0I9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Tetratricopeptide TPR_2 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46515">
        <property type="protein sequence ID" value="SLM46515"/>
        <property type="gene ID" value="NSJP_0343"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0343"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="418"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="469" mass="52770" checksum="7C82566F21E338B7" modified="2017-06-07" version="1">MNGAIAASNRQIICLMILTAVVYANAFSGSFQFDDFSAISENPHLGSWRTFVGHLDHMVRPVLYATFLADRTLFGGNETGYHILNWLLHLGCGILMYLVLTHGVTEQERHVPFWTAAFFLVHPLQTETVTYISGRATGLMAFFYLSAFALYLKATEPRVDGPTQRLYLIAALVLFALALGSKETAVTFPLALLLWDMTIRRLTGAALRRSFMFRHAPFWLLLLAVAAAWIFWHPRYLALARFSLEIRPLTENLLSEVHALSYSLRLLFSPWEQNFDHDLPVFHSVFQWPLPLDLVILGGLAAAALLTLRRVPLFSFGIGWFFLQLIPTSIIPRNDLLSERNLYLASIGLLLAIVISASHLARRPVGVPPLPKIARIGTAALAWLLISTLALMTIQRNGLYRGPVLLWSDAIEKSPRKARPHNNLGHAYALRGDWDNAIEEFRTAARLDPDYALAQENLRAAYLHHIGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0R9</accession>
    <name>A0A1W1I0R9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46574">
        <property type="protein sequence ID" value="SLM46574"/>
        <property type="gene ID" value="NSJP_0402"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0402"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="17"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="129" mass="14183" checksum="90C8C0AAF52C40E5" modified="2017-06-07" version="1">MKKSESKSAPAATTASERRKLVRATLVGSALVSPKSGSKAITAVLDNVNKVGAGLHAKETLGMGERVTVSLAFLDSDRMEQQEKLNGAVAWVKPWEKGYLIGVVWDEVVTKEKNRWLYYYLEETIKSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I118</accession>
    <name>A0A1W1I118_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4HB_MCP_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0526"/>
    <dbReference type="EnsemblBacteria" id="SLM46698">
        <property type="protein sequence ID" value="SLM46698"/>
        <property type="gene ID" value="NSJP_0526"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0526"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="4HB_MCP_1" evidence="3">
        <location>
            <begin position="17"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="262" mass="29102" checksum="64B8E7E4B0CD696B" modified="2017-06-07" version="1">MVHPVQWILSFKPTAAQLVVSILIAGLGWLSGQALSRVDQDLRIMYTEYTLGAADLAHISADVMRYRNTIIRALEADSQKEFERITESLPTQRARIQQAVDRYAAAGLRVSRSGRSEPEDIEAVRRSLDQYFSAASTTVQLLTQEWTASSQSEREVLRRKAEEHAADNAGPKMIQVSLALDRLLDTVADVAKDMRDEGTRAIQDTSLLLVVGSFFIAFLNLFLSKRRHAAPQDDSAELSHTPSSSVPLPLSNDHTNSLLRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I122</accession>
    <name>A0A1W1I122_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Agmatinase</fullName>
            <ecNumber evidence="4">3.5.3.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">speB</name>
        <name evidence="4" type="ORF">NSJP_0528</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0528"/>
    <dbReference type="EnsemblBacteria" id="SLM46700">
        <property type="protein sequence ID" value="SLM46700"/>
        <property type="gene ID" value="NSJP_0528"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0528"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="311" mass="33682" checksum="AE1D73BB2FF35076" modified="2017-06-07" version="1">MTLPDGWEGYERNFLGLEEPWCHPDQAGIYVLPAPYEHTSSYMPGSDKGPSAIIEASHQVEFYDEMLRCEPYREWGGIATTQSLNLAGSVDQAAVDAIEAFVRPHVGTGRFLVTLTGEHTGALGAIRAHAKKYPHLCVLQIDAHGDLRNAYQGNPYSHASVMARVVDDGLPLVQVGVRSICPEEIERIKHTKSITTFFAAPLLDPSGPYEGKASRWIPDVVNACTGPVYLTFDCDGLDASLVPALGTPEPGGLGWYDTLNLVAALANGPGILGMDVSEIAPIEGFVAPQFCVARLIYRMLGRIRAGRRVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I146</accession>
    <name>A0A1W1I146_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_0545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0545"/>
    <dbReference type="EnsemblBacteria" id="SLM46717">
        <property type="protein sequence ID" value="SLM46717"/>
        <property type="gene ID" value="NSJP_0545"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0545"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="105"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="386" mass="41699" checksum="284C523D2E22FCBD" modified="2017-06-07" version="1">MATDIIMPQLGESVAEGTVVKWFIRPGGMIQKDQALVEVETEKVDLDIPSPVTGVLSEIIIPEGGTVPVGTLLARIESTPPSDVINRVGGVIVRPSQPVSDGDGRYSPAVRQLATAHGLDLSHVKGTGTGGRVTKKDVQEFIAETGGLAASPPAGTELSMGEEVRPLTQMRRTIAERMVSSRRTSAHVTTFFEADFSGVAKFRDTLRQSSGQSVTYLPFVIRAVTRAIRDLPVLNSSWREDGIVIKKDIHLGIATALDEGLLVPVVRHADRKGLTLLAKEVADLAERARTKKLNPEEVQGGTFTITNHGGFGSLFSTPIIHQPQTAILGVGAIQKRPMVIDDAIAIRTMGYLSLSFDHRVIDGATADQFMAKVRDYLEQSQWEPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I167</accession>
    <name>A0A1W1I167_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Malate dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 8" type="primary">mdh</name>
        <name evidence="8" type="ORF">NSJP_0411</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible oxidation of malate to oxaloacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDH/MDH superfamily. MDH type 3 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0411"/>
    <dbReference type="EnsemblBacteria" id="SLM46583">
        <property type="protein sequence ID" value="SLM46583"/>
        <property type="gene ID" value="NSJP_0411"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0411"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01339">
        <property type="entry name" value="LDH-like_MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00487">
        <property type="entry name" value="Malate_dehydrog_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011275">
        <property type="entry name" value="Malate_DH_type3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01763">
        <property type="entry name" value="MalateDH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="6">
        <location>
            <begin position="33"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="7">
        <location>
            <begin position="176"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="38"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 4">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="147"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 4">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 4">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="340" mass="35515" checksum="7E87A587D2C56520" modified="2017-06-07" version="1">MSRFNAGGIQPHACSGFGIQESGLIGGDMGRPKITVVGAGNVGGTTAQRLAEKDAYDVVLVDIIEGVPQGKALDISQAGPVCGYSTRVVGTNGYDETAGSSVAVITSGMPRKPGMSRDELLTTNARIVKSVVTELVSRSPGIILILVTNPLDAMVHVALQVSGLPKSRIIGMAGVLDSARMRTFIATELKVPGPEVEAMVLGGHGDTMVPLPRYTTVKGRPVSELLPKERLDAIVKRTRDGGAEIVGLLKTGSAFYAPSASAVDMVEAIHRDQKRVLPCAVLCDGEYGLKNVVVGVPVKIGRGGAEQVVEYELTAEERSALSASAAAVRELCTVVDRLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I178</accession>
    <name>A0A1W1I178_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chaperone protein DnaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dnaK</name>
        <name evidence="5" type="ORF">NSJP_0575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0575"/>
    <dbReference type="EnsemblBacteria" id="SLM46747">
        <property type="protein sequence ID" value="SLM46747"/>
        <property type="gene ID" value="NSJP_0575"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0575"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010236">
        <property type="entry name" value="ISC_FeS_clus_asmbl_HscA"/>
    </dbReference>
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        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01991">
        <property type="entry name" value="HscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="606" mass="65287" checksum="F87D8D5B3FDC601A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I195</accession>
    <name>A0A1W1I195_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46776">
        <property type="protein sequence ID" value="SLM46776"/>
        <property type="gene ID" value="NSJP_0604"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0604"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="71" mass="8039" checksum="5A2EC5C5A2E76B96" modified="2017-06-07" version="1">MRTISEPRSQHKPALLSDRFTAMLPKLIEFLEQEYRNMPRPPASPSHPHRSLLAAAHHSLAALSELQEATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I196</accession>
    <name>A0A1W1I196_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46639">
        <property type="protein sequence ID" value="SLM46639"/>
        <property type="gene ID" value="NSJP_0467"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0467"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="108" mass="12294" checksum="8EB131AC4FAC55E8" modified="2017-06-07" version="1">MPIHPVLWTIGHSTRPSETFIASLHVWGIEQLADVRTIPRSRHNPQFNAEALAVETTRAGMTYIGMPGLGGLRKPRKDSPNKGWRNASFRGYADYSRPVNSRRPWRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1A9</accession>
    <name>A0A1W1I1A9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46785">
        <property type="protein sequence ID" value="SLM46785"/>
        <property type="gene ID" value="NSJP_0613"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0613"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="95" mass="11171" checksum="996B2D91962EBB09" modified="2017-06-07" version="1">MHFVQPSFHLFRHTIKSGVELKVKGIKFLVCDAAFRMESVHKVRVWLEGLHHGRTQDTERFPSSWAKVDLNVFSRHGYLSHLIDEWWETAESPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1B4</accession>
    <name>A0A1W1I1B4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46771">
        <property type="protein sequence ID" value="SLM46771"/>
        <property type="gene ID" value="NSJP_0599"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0599"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="167" mass="18387" checksum="F9383A3D98FA640D" modified="2017-06-07" version="1">MASEIVTHPNPENAPVKPGRIPADDLAAIAARYRAGESLKLIGQSYGVTDEAVRQRLEKWALAGHGDTEFGQMVTDYLVENAIQAKDRMVNASDVLGLARGREEVRYWLWMLERRRPKLYGPKQHIEQDTAVTITINRTPPPVVNAPITVTGSLVDHSGNETDGSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1E7</accession>
    <name>A0A1W1I1E7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0664"/>
    <dbReference type="EnsemblBacteria" id="SLM46836">
        <property type="protein sequence ID" value="SLM46836"/>
        <property type="gene ID" value="NSJP_0664"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0664"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="107" mass="11631" checksum="2E60B870A8FA6989" modified="2017-06-07" version="1">MMSIAEACIDPDHPALAGHFPGNPIVPGVLILSKVLEALDRHYGTLSGPSSWPAVKFIGPLHPGERFAVAVENHSPDEIAFSVIVNRKTIALGTMRRHRPFRTDVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1L8</accession>
    <name>A0A1W1I1L8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_0587</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0587"/>
    <dbReference type="EnsemblBacteria" id="SLM46759">
        <property type="protein sequence ID" value="SLM46759"/>
        <property type="gene ID" value="NSJP_0587"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0587"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="424" mass="47594" checksum="9A0B21FF3A04F09F" modified="2017-06-07" version="1">MKGLSLINPVDPVQLDRETLRIYEICEGCRRCFNLCPSFNTLLDRIDVYEGDVAKLTPADHHRVVDECYYCKLCFNHCPYTPPHQYDLDFPLLMVLWKKRLAAERGVRWRDRLLIMTDVIGRLGSLTAPLTNRFLENRLVRRLLELVLGVHRERRVLHFSRETFPAWFGRRGTPMKGSNPVRKVALFSSCLVNYQATDVGKATVQVLEKNGVEVVLPEQRCCGMPSFDLGDDRAIGVAARANVDSLYPWVAQGYDVVVPTVSCSLMLKREYPGVVADDKTKRVAERTFDVCEYLMKMKKDGQLATDFMRKPGRVAYQVPCHLRDQNIGFKSKDLMECAGAQVEVIEKCSGHDGTWSAKTEFFPLSMTIAAKAVRAIEKNPSDLVASDCPLAGLQLDQAGASAHVGGTASLHPIQIVRDAYGLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1P3</accession>
    <name>A0A1W1I1P3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46904">
        <property type="protein sequence ID" value="SLM46904"/>
        <property type="gene ID" value="NSJP_0732"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0732"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="90" mass="10187" checksum="4F275284344F8AC0" modified="2017-06-07" version="1">MKAGGCRRCDSLKRGLLTLAQNPNLTLERQYLLLQAIRTYCSTSRQHERIVIALLLEPYNASHYQGGPAIQDRVPVNLFHRDGPHLSIDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Q2</accession>
    <name>A0A1W1I1Q2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0742"/>
    <dbReference type="EnsemblBacteria" id="SLM46914">
        <property type="protein sequence ID" value="SLM46914"/>
        <property type="gene ID" value="NSJP_0742"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0742"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="212" mass="23477" checksum="4DA3EFB1B972E18E" modified="2017-06-07" version="1">MGGMIEAIITVLGRFVMNTISSFGYSGIFLTMAIESACIPLPSEIIMPFSGYLVTTGQFSLMGVTLAGAIGNVAGSIVAYYAGVWGGRPFVERYGPYMLVSRRDLDLADRWFQKYGDAAVLFSRMLPVVRTFISLPAGIAGMNFPRFVLFTFVGALPWCYLLAYIGVKMGEQWDQLHDYFHQLDIVIGVLLVLAGGYFLWSHWPRRGSDHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1R5</accession>
    <name>A0A1W1I1R5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="5">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="5">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">truB</name>
        <name evidence="8" type="ORF">NSJP_0763</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0763"/>
    <dbReference type="EnsemblBacteria" id="SLM46935">
        <property type="protein sequence ID" value="SLM46935"/>
        <property type="gene ID" value="NSJP_0763"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0763"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="6">
        <location>
            <begin position="32"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="7">
        <location>
            <begin position="181"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="316" mass="33914" checksum="4CC9D4E77FFBD912" modified="2017-06-07" version="1">MMTNVAQSTLDGVLTVCKEVGWTSHDVVAKIRHVLGGAKVGHAGTLDPAATGVLPVLIGRGTRIAEYLVEWDKEYRAVLRLGETTDTQDATGTLVDRQFTGHITPAAIREVASRFQGAIEQVPPMYSAVKVAGVPLYKSARAGKTVARQARTVTVHSLDILEIDGQNVTLRVVCSKGTYVRTLCADLGAALGVGGHLLSLERSRVGPLMLDQASTVDEVVARYAIGDLGTAVISLDQALKAFPVVVVDDLATERIRHGAPVQMSHVRDIPEDRHAVAESDQPVRVHDGEGRLLAIGKYRVSNEMVLAVEKLLVEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1W5</accession>
    <name>A0A1W1I1W5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHASE3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46987">
        <property type="protein sequence ID" value="SLM46987"/>
        <property type="gene ID" value="NSJP_0815"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0815"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007891">
        <property type="entry name" value="CHASE3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05227">
        <property type="entry name" value="CHASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="CHASE3" evidence="2">
        <location>
            <begin position="45"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="214" mass="24078" checksum="2503E8DA95907F41" modified="2017-06-07" version="1">MRQRNKVWAYLCTGVLLLLFFGAEQIYILKQWHEVSDAQELRNAITVQVLQLRRLATDIDSGFRGYALMRQSVFLVPVVAAEAEIPPALDRLTELTEKTPSLKGSVQVLKRRLAELIETKRQLTFKIGSGQEQEVLNYVRGGDGVALAKTIANVFDDLDSKIEREFRETDEAQDGYWKQAMWQLIAAQAGAVLVGLLLMKVVSAAFAVPRRVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Z0</accession>
    <name>A0A1W1I1Z0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46879">
        <property type="protein sequence ID" value="SLM46879"/>
        <property type="gene ID" value="NSJP_0707"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0707"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="39" mass="4431" checksum="9C6CC1B863662C7C" modified="2017-06-07" version="1">MIDRARVETDSPTSDPPEVLTLFHHFSRLGYSARQSILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I212</accession>
    <name>A0A1W1I212_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0863"/>
    <dbReference type="EnsemblBacteria" id="SLM47035">
        <property type="protein sequence ID" value="SLM47035"/>
        <property type="gene ID" value="NSJP_0863"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0863"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="86" mass="9808" checksum="57D68C04C618B3A3" modified="2017-06-07" version="1">MIELIIFDCDGVLIDSEIIAKRIESEELARFGCTITSEEIMDRFMGSIDNWKLPHPTNHSPLPGSSVMDRERRCIRTRCVFSSFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I272</accession>
    <name>A0A1W1I272_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfaEb</name>
        <name evidence="7" type="ORF">NSJP_0925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-D-glycero-beta-D-manno-heptose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59967"/>
            <dbReference type="ChEBI" id="CHEBI:61593"/>
            <dbReference type="EC" id="2.7.7.70"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.70" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0925"/>
    <dbReference type="EnsemblBacteria" id="SLM47097">
        <property type="protein sequence ID" value="SLM47097"/>
        <property type="gene ID" value="NSJP_0925"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0925"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033786">
        <property type="term" value="F:heptose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011914">
        <property type="entry name" value="RfaE_dom_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02199">
        <property type="entry name" value="rfaE_dom_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="6">
        <location>
            <begin position="32"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="162" mass="17522" checksum="DFDEAC9B371745C0" modified="2017-06-07" version="1">MMSGMSTKVLTMGELVPVLQRARASNKRVVFTNGCFDLMHVGHTRYLAEAKQLGDLLVVGVNSDDSVRALNKAPGRPVVQDAHRAEVLAALESVDYVVVFSEPDPLNLITAVQPDVLVKGGDWPLDRIVGRDVVERRGGVVKTIPLVPGASTTSIIQRIRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2E7</accession>
    <name>A0A1W1I2E7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative thiol oxidoreductase, DsbA family, FrnE subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1014"/>
    <dbReference type="EnsemblBacteria" id="SLM47186">
        <property type="protein sequence ID" value="SLM47186"/>
        <property type="gene ID" value="NSJP_1014"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1014"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="226" mass="25548" checksum="CC5A7FF0ADC9B7C7" modified="2017-06-07" version="1">MNNRPLTIEVYSDVVCPWCYVGKRRLERALAQRQGSVKGEIIWRPFQLNPTMPAEGVERTAYLEAKFGSMEAFRRLEEHVTDAAREERIAFAFERIARTPNTFLAHRLIWYAALRDRQDEVVESLFKGYFQEGEEIGSQASLVRLGRHAGLDGADVERFFRTDEGTVEVKEEEAAGGRLGIRSVPYFVVNRAYGISGAQPVERFVAAIDTIQAQPVTAGDHAPDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2I1</accession>
    <name>A0A1W1I2I1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroloquinoline-quinone synthase</fullName>
            <ecNumber evidence="2">1.3.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Coenzyme PQQ synthesis protein C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pyrroloquinoline quinone biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">pqqC</name>
        <name evidence="4" type="ORF">NSJP_1023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone</text>
            <dbReference type="Rhea" id="RHEA:10692"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58442"/>
            <dbReference type="ChEBI" id="CHEBI:58778"/>
            <dbReference type="EC" id="1.3.3.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PqqC family.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.11" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1023"/>
    <dbReference type="EnsemblBacteria" id="SLM47195">
        <property type="protein sequence ID" value="SLM47195"/>
        <property type="gene ID" value="NSJP_1023"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1023"/>
    <dbReference type="UniPathway" id="UPA00539"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033732">
        <property type="term" value="F:pyrroloquinoline-quinone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018189">
        <property type="term" value="P:pyrroloquinoline quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00654">
        <property type="entry name" value="PQQ_syn_PqqC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011845">
        <property type="entry name" value="PqqC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039068">
        <property type="entry name" value="PqqC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40279">
        <property type="entry name" value="PTHR40279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02111">
        <property type="entry name" value="PQQ_syn_pqqC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 2" id="KW-0884">PQQ biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TENA_THI-4" evidence="3">
        <location>
            <begin position="18"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="253" mass="28977" checksum="C81E48437DD4A548" modified="2017-06-07" version="1">MNRRSDARPLSNEAFLAKLRREGAARYHDRHPFHLRMHQGKLTKRQLQQWVLNRYYYQTRIPIKDALILSKSEDPAFRRVWIRRVRDQDGDDAATGGLDSWLILARGVGLDPDEVRSLRSVLPGVRLACDGYVQFVREASLLEAVASSLTELFAPTLMSRRLDAWGRHYPWVGSGALTYFRMRVSRADLDARHAVSFVMREATTRERQTACIEALIKKAAILWHLLDCIQADCVRPSANGRNAHARFPRQASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2L4</accession>
    <name>A0A1W1I2L4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">UDP-3-O-acyl-N-acetylglucosamine deacetylase</fullName>
            <shortName evidence="12">UDP-3-O-acyl-GlcNAc deacetylase</shortName>
            <ecNumber evidence="4 12">3.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">lpxC</name>
        <name evidence="13" type="ORF">NSJP_1062</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate</text>
            <dbReference type="Rhea" id="RHEA:67816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:173225"/>
            <dbReference type="EC" id="3.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the LpxC family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.108" evidence="4 12"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1062"/>
    <dbReference type="EnsemblBacteria" id="SLM47234">
        <property type="protein sequence ID" value="SLM47234"/>
        <property type="gene ID" value="NSJP_1062"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1062"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008759">
        <property type="term" value="F:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103117">
        <property type="term" value="F:UDP-3-O-acyl-N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00388">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004463">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011334">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015870">
        <property type="entry name" value="UDP-acyl_N-AcGlcN_deAcase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33694">
        <property type="entry name" value="PTHR33694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03331">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00325">
        <property type="entry name" value="lpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM47234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="316" mass="34240" checksum="13BF289ABE9160D3" modified="2017-06-07" version="1">MRLQQTLANTITCTGVGLHSGQPVTMTMRPAPPDTGVVFVNRNGHAGDSLAATVRHLVPTELCTAISGNGFQVKTIEHVLAALAGLNVDNVFVEVDAGEAPVMDGSSASFVRLIRSAGLISQAKRQPYLKMTRPLEVVDGSRRIRIEPSSMPRITYSIQYNHPLIQTQTYTYEYSADAFESEIADARTFGFLEEVEALWARGLGRGGNLDNTVVLSKDGVLNESGLRFADEFVRHKVLDLIGDFALLGVPFIGHLVADRSGHALHTKLVKQILDHPDCWVLLNADHNIDHSLTVPEFLSPVSTSRPAAPVALQAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2M0</accession>
    <name>A0A1W1I2M0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47247">
        <property type="protein sequence ID" value="SLM47247"/>
        <property type="gene ID" value="NSJP_1075"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1075"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="86" mass="9617" checksum="B2023582093F9427" modified="2017-06-07" version="1">MLTRRWASARTCSFISSALPILPPGWTYRLPQPKEHGNEHILERPSRDALPLVVQHGGSCPHRYGRRIRGTGLCGDLAYAVLLELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2U3</accession>
    <name>A0A1W1I2U3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">msrA</name>
        <name evidence="7" type="ORF">NSJP_0971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0971"/>
    <dbReference type="EnsemblBacteria" id="SLM47143">
        <property type="protein sequence ID" value="SLM47143"/>
        <property type="gene ID" value="NSJP_0971"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0971"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012099594" description="Peptide methionine sulfoxide reductase MsrA" evidence="5">
        <location>
            <begin position="28"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="PMSR" evidence="6">
        <location>
            <begin position="38"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="209" mass="23531" checksum="E1DCFA78E34E8753" modified="2017-06-07" version="1">MRRISRIFILLAVIQTSFGALMSPLSAAPNTPPVAAAKAYFAGGCFWSMERAFEKIDGVSGAVSGFMGGTVKDPSYEEVSTGQTGHMESVEVRYDSSKVTYAQLLDVFWKNIDPLTTDAQFCDHGPQYRTAVFYQSEEEKRLAEDSKRALEQSNRFTSPIVTQVLHVSEFFAAEEYHQDFYKKNPVRYRFYNSTCGRTQRLEALWGPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Z0</accession>
    <name>A0A1W1I2Z0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47370">
        <property type="protein sequence ID" value="SLM47370"/>
        <property type="gene ID" value="NSJP_1198"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1198"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009937">
        <property type="entry name" value="Phage_holin_3_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07332">
        <property type="entry name" value="Phage_holin_3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="137" mass="15030" checksum="ABEE23943B32FE5E" modified="2017-06-07" version="1">MNDTTPRHIGVVTLLGGILEDLQTLMRQEAQLLRDEFRLELSKTGRAASGFGIGILCAAIAALFLLLMLVHGLTVWAGLSLWASYGVVGGLLAGLSVVCLVRAQSMAGRVHLMPRRSLFAIKENVQWIKERVTYKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I305</accession>
    <name>A0A1W1I305_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPFH domain/Band 7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47387">
        <property type="protein sequence ID" value="SLM47387"/>
        <property type="gene ID" value="NSJP_1215"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1215"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PTHR23222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012212963" evidence="1">
        <location>
            <begin position="22"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="28"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="297" mass="32718" checksum="C44FB2B7A9DF30CD" modified="2017-06-07" version="1">MSIASRPILVLALTLSAASGAGGCAGTTVQPGERGLFWHPFTEGLSTEPLRDGFYWRAVWNSVYVYDVRWQSYTETVDALSSDDLLVELKTAVIMRPIPQEVYFLAHEIGTDFYPRVVKPELLAAVRSVVSGYAMVHVPEKSAEIASKVQAVVVEKLSGRHLEIASVALADIELAKVVLDAVERKQAKEQEKEQKEFELVIAEKDAEIARRRARGEGDAVRIRSEGEAEGLRIRALGQAQAQDTITKTLTPEYLQYKLYDSPNAKLVLLPDKLNVPVLVSPGLDQPHSLSQGEVPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I307</accession>
    <name>A0A1W1I307_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative thiamine pyrophosphate-containing protein YdaP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ydaP</name>
        <name evidence="6" type="ORF">NSJP_1179</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1179"/>
    <dbReference type="EnsemblBacteria" id="SLM47351">
        <property type="protein sequence ID" value="SLM47351"/>
        <property type="gene ID" value="NSJP_1179"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1179"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="198"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="388"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="583" mass="63084" checksum="367A97DBE48F74B2" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I349</accession>
    <name>A0A1W1I349_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1250"/>
    <dbReference type="EnsemblBacteria" id="SLM47422">
        <property type="protein sequence ID" value="SLM47422"/>
        <property type="gene ID" value="NSJP_1250"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1250"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0680">Restriction system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="164" mass="18523" checksum="AEDC476065735759" modified="2017-06-07" version="1">MSPFATVVHPVRSLYSERYGQCCKGQVNSESHGRLFRRLTKFWVMAWEQAIAIAKVEDDGCVGNHRMLKCESKTDCAVTGFLWYYFTTPDGFDKVYAASPGTWARNRTMTAPSLMAIEVPLPRLIVQQTFDRLHAEVVALKDKHAAIRTANKALLPAILERVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I396</accession>
    <name>A0A1W1I396_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RNA-binding protein RbpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rbpB</name>
        <name evidence="3" type="ORF">NSJP_1273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1273"/>
    <dbReference type="EnsemblBacteria" id="SLM47445">
        <property type="protein sequence ID" value="SLM47445"/>
        <property type="gene ID" value="NSJP_1273"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1273"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="107" mass="11136" checksum="F4124C951F2D236A" modified="2017-06-07" version="1">MGSKLYVGGLPYAATETQLTTLFAAHGKVESARVIADKFTGQSRGFGFVEMSTPEEAQAAITALNGSQMDGRSLTVNEAKPQESRSGGGKRFGGGGSGNDFGGRNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3G6</accession>
    <name>A0A1W1I3G6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47540">
        <property type="protein sequence ID" value="SLM47540"/>
        <property type="gene ID" value="NSJP_1368"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1368"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010696136" evidence="2">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="75" mass="8441" checksum="624053B855E58742" modified="2017-06-07" version="1">MKRMLMAVMAVAVAISFSAPSFAGEEKKDKKDEKKGGHVLVYGEEKKDKKDEKKGGHMDTFGDKKEEKKEEKKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3R6</accession>
    <name>A0A1W1I3R6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">atpG</name>
        <name evidence="10" type="ORF">NSJP_1419</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1419"/>
    <dbReference type="EnsemblBacteria" id="SLM47591">
        <property type="protein sequence ID" value="SLM47591"/>
        <property type="gene ID" value="NSJP_1419"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1419"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="292" mass="32564" checksum="34A6759CF3636947" modified="2017-06-07" version="1">MPSLQSLRRKIAAFKNTQKITKAMKMVAAAKLKRSQDRILAARPYAHKMRSVLGNLSRRVNRTAHPLLRKHGGRKVEILVVTSDRGLCGGFNGNIIRKTVEFLRQSEAQGLQVNLSIVGRKGRDYFRRRAWPIRQEWTGVFDKLSFEHAIDIGDDVSSNFVNGTFDEAYVVYNEFKSAIQQRVIVEKLFPIDAAAEFGSVQAEGTTGGSYLYEPDEAELLNALVPKHVQVQAYRILLESAAAEHGARMAAMDGATRNAGQLIKKVTLYYNKTRQAAITKELMDIVGGAEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3W1</accession>
    <name>A0A1W1I3W1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47684">
        <property type="protein sequence ID" value="SLM47684"/>
        <property type="gene ID" value="NSJP_1512"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1512"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="125" mass="14139" checksum="4DA7A8E33CBB9555" modified="2017-06-07" version="1">MRLQLKEESEGGWQTRMGDENLALDYLIVTPATVSPANRAHHRTQSCHRTNQCEHRKTDHEKEPCTNILEEVMLHDASFISGTSRNQLCQPHAHVHGANGSCFLSHLPQHGQCLVHACRYCLIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I405</accession>
    <name>A0A1W1I405_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1509"/>
    <dbReference type="EnsemblBacteria" id="SLM47681">
        <property type="protein sequence ID" value="SLM47681"/>
        <property type="gene ID" value="NSJP_1509"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1509"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="370" mass="42077" checksum="16BBF71B25C80529" modified="2017-06-07" version="1">MLNKDAPAHISSDPVRAIVEIPQSPQHPNSRGVRRLALYALSFGLSLFVAVVCSELILRSTGHRPWTYDTLDRNEPRMNEPDPELGWHSKRGTYTVPPYVPAGQSTSVTVLDGGRRATGTTDPGGRREIVFVGDSFTYGLAISDHETYPWKLQQMFPSFKVLNYGTSGYGTYQSLLVLERELPLLTSPAVVVFGFFFHQEVRNVATPEWLRGLSLHQRRAHVYLPYVSLDSDGTLVRHLPVRYPILPFMEQSALMTFMVDRYVRFTGERRRAQGRQVMERLVVEMKHLSEKHGARFLVAMLDGPKETMAYYTERFQHHQIELVDCNFPLTDDMRVPGEGHPNDQMNTLWAHCIQQKLVNGVLSSTESPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I418</accession>
    <name>A0A1W1I418_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 2-oxoglutarate-Fe(II) oxygenase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1586"/>
    <dbReference type="EnsemblBacteria" id="SLM47758">
        <property type="protein sequence ID" value="SLM47758"/>
        <property type="gene ID" value="NSJP_1586"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1586"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="121"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="257" mass="29710" checksum="5AAA75BBD9B9D80A" modified="2017-06-07" version="1">MMGGAMTTQTLDTIAEAVDQAVARLDFDRLHREYWEQNEFLVIPQFLDRAMVEEWLVPQAQGVKGDLNRNYIPGHKKGGSVSYYTVMEKAPRFLDLYRSQVFIEFLSRLSHAKLRLCPDNDPHSCALYYYTEPGDHIGFHYDTSYYKGSRYTILMGLVDQSTHCKLVCELFKDDPVRPSKRLELITQPGDMVIFNGDKLWHAVTPLGPNEERIALTMEYVTNPDMGTFKRLYSNLKDSFAYFGLRAVFKRALSLPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4A9</accession>
    <name>A0A1W1I4A9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47781">
        <property type="protein sequence ID" value="SLM47781"/>
        <property type="gene ID" value="NSJP_1609"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1609"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="73"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="270" mass="29748" checksum="F7992952CD703B17" modified="2017-06-07" version="1">MGDRTHGLQVIRGAGQSGTRPQHFRSAQRMNSAIGTTETFGPAKSRDDLAVALRTMEQRLAALVEDRGQLTRDLHDCVLQSLYAIGLTIESTRRAQPQRRPVADQTDDLLIDQLNTLIQEVRGMIRTLESGNVQEFDLASEIKTLIKTYGEISTLQITTDIVPRAVALATNEEKREVLMIIREAVSNCVRHAKATRASISLYAQGRHLRLAIADDGVGFTQGDNRTKGYGFANMSARAKKLGGRLLVRSHVGEGTHILVEFALEPDHLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4E3</accession>
    <name>A0A1W1I4E3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mraW</name>
        <name evidence="6" type="synonym">rsmH</name>
        <name evidence="8" type="ORF">NSJP_1725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1725"/>
    <dbReference type="EnsemblBacteria" id="SLM47897">
        <property type="protein sequence ID" value="SLM47897"/>
        <property type="gene ID" value="NSJP_1725"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1725"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="25"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="291" mass="32401" checksum="9606AD3157951493" modified="2017-06-07" version="1">MPNEIVSWLMPGPDAIVLDCTVGYCGHAESILKSSAPSGRVIGIDRDPQAIHACEVESARFGGRLQLVRGHFVDLKRHLADRGVAQVSGVLFDLGVSSPQLDEPARGFSFRAPGPLDMRMDQSVGRTAAEIVNHADEADLAKMIFEFGEERFSRRIARAIVRDRTRKPLETTEELVATIEGAVPSSYRRGRLHCATRTFQALRIAVNEELDYLEPALRDAADVLKPGGRLCVLSFHSLEDRIVKRTFRSLSDGRLTIKTKKPLRPTEEEMAHNPRSRSAKLRVAERTHEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4H4</accession>
    <name>A0A1W1I4H4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4 11">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 16" type="primary">murC</name>
        <name evidence="16" type="ORF">NSJP_1734</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4 11"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1734"/>
    <dbReference type="EnsemblBacteria" id="SLM47906">
        <property type="protein sequence ID" value="SLM47906"/>
        <property type="gene ID" value="NSJP_1734"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1734"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="13">
        <location>
            <begin position="44"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="15">
        <location>
            <begin position="146"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="14">
        <location>
            <begin position="349"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="148"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SLM47906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="499" mass="54161" checksum="97CB1707443A8BC6" modified="2017-06-07" version="1">MTSVSLLERGHFDGTGQRNGHGFNPSQPISGLRRAPMFRKTQQIHLVGIGGAGMSGIAEVLLTLGYKVTGSDLQASDTTRRLEELGGRIFIGHEESNVGDAQVVVISSAVSPVNPEVIFAKAKQVPVIPRAEMLAELMRLKFGVAIAGAHGKTTTTSMVANVLAQGGLDPTMVIGGKVNALGSHARLGRGDLLVAEADESDGSFLRLSPTVVAVTNLDREHLDHYGSMERINESFLEFINKVPFYGLAVLCADDDRLRALFPKIVKRYQTYGLREIDGISPDFRATDISLKQWGAEFRAFYRGRNLGPFRLSIPGIHNVSNALAAIAIGIELDVPTDLIRKALAAFTGVERRFHLRGEAGGIMVVDDYGHHPTEIKATLAAAKQGWTDRRLIVLFQPHRYTRTRDLLEDFSRAFTDADRVFLTDIYAASEQPIPGVSGARLAEAIRATGHQSVTFVERKEDLVDQVFPEIKPGDLVLTLGAGDIWKSGPALLARLAPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4M2</accession>
    <name>A0A1W1I4M2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="6">RPPK</shortName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="6">P-Rib-PP synthase</shortName>
            <shortName evidence="6">PRPP synthase</shortName>
            <shortName evidence="6">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">prsA</name>
        <name evidence="6" type="synonym">prs</name>
        <name evidence="8" type="ORF">NSJP_1753</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1753"/>
    <dbReference type="EnsemblBacteria" id="SLM47925">
        <property type="protein sequence ID" value="SLM47925"/>
        <property type="gene ID" value="NSJP_1753"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1753"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="6">
        <location>
            <begin position="223"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="38"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="97"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="313" mass="33985" checksum="6F1E4872215F9D20" modified="2017-06-07" version="1">MSRELMIFSGNANLALAHEICAYLGVKLGEATVASFSDGEIRVKIEENVRGADVFVVQSSCEPVNDSLMELLIMIDALKRSSANRITAVIPYFGYARQDRKDQPRVPISAKLVADLISTAGTDRVLTMDLHAGQIQGFFNVPVDHLYALPVLLDYIMKKKVKDLVIVSPDAGGVERARAFAKRLQATLAIIDKRREGPNQTQIMNIIGDVEGKSALLLDDMIDTAGTIVQGAQACADKGAREVWTACTHAVLSGPALDRLQGSCVKQVIVTNTIPLRGKDQTCPKLYQLSVAPLLGEAIRRIHEDESVSSLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4W3</accession>
    <name>A0A1W1I4W3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP citrate synthase</fullName>
            <ecNumber evidence="4">2.3.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">aclB</name>
        <name evidence="12" type="ORF">NSJP_1799</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + ADP + oxaloacetate + phosphate = ATP + citrate + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1799"/>
    <dbReference type="EnsemblBacteria" id="SLM47971">
        <property type="protein sequence ID" value="SLM47971"/>
        <property type="gene ID" value="NSJP_1799"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1799"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp_2" evidence="10">
        <location>
            <begin position="10"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate_bind" evidence="11">
        <location>
            <begin position="231"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM47971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="398" mass="43319" checksum="B33161E2895C4326" modified="2017-06-07" version="1">MAKVLEGPGMGLMKKWGIAVPQYVVVTSSDELAKLGQANEWMKKSKLVAKAHEALGSRFKLGLVKVGLDLNEAVAATKEMIGRQVGSITVTQVILSEMIPHKEEYYCAVKSTREGSEILVANCGGIEVESNWERVKRLVLDVGQQPTAEALEKLAKDAGFSGALTKKMADFSGKMFTCFDNEDAQYLEVNPVVVRESDGELVALDAVTLLDGDAKFRHPDWNFQFAAEFGRAYSKDEMEVMAVDSKIKGSVKFIEIPGGDTAMLPAGGGASVYYSDAVVARGGKLANYAEYSGDPPDWAVEVLTEKVCSLPHIKHIIVGGAIANFTDVKKTFGGIINGFRKAKADGKLKQVKIWVRRGGPREKEGLDAMRALKDEGFDIHVFDRNTPLTDIVDKALLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I524</accession>
    <name>A0A1W1I524_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48085">
        <property type="protein sequence ID" value="SLM48085"/>
        <property type="gene ID" value="NSJP_1913"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1913"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="236" mass="27552" checksum="3E62189E1C6CC571" modified="2017-06-07" version="1">MQEELKLLTSQRNEMFLMLQDNKFSPSEFEWIRWASVTGNFKTVPALRHIPTGYYFVVDRAENRDGEYGFFVQYSPGRETKLEGDEAGEWSVVTLNFARWLSYIMRETELPDLWEGLVKDTQLIRDTDQQSSDNLPFTNEELPRVRNAIEEIKRYIHKTHELSEAQWKMIDARFDYLEQKAGEFGRKDWMHIAVSVLLSIGVDHLQSSTSTRDLFQFASEVFKQALGAILYLAGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I535</accession>
    <name>A0A1W1I535_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48124">
        <property type="protein sequence ID" value="SLM48124"/>
        <property type="gene ID" value="NSJP_1952"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1952"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="60" mass="6837" checksum="3A70A9B1FCCCCB43" modified="2017-06-07" version="1">MKGRSLEMLLAIVCKDRTNPAMQNSKRDSEGFSRVFGVYDDKVSSWDRLSVFWGGYDQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I559</accession>
    <name>A0A1W1I559_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-glutamate O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_1960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="2.1.1.80"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1960"/>
    <dbReference type="EnsemblBacteria" id="SLM48132">
        <property type="protein sequence ID" value="SLM48132"/>
        <property type="gene ID" value="NSJP_1960"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1960"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.155.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036804">
        <property type="entry name" value="CheR_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheB-type methylesterase" evidence="9">
        <location>
            <begin position="27"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="CheR-type methyltransferase" evidence="10">
        <location>
            <begin position="233"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="868"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="687"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="984" mass="110152" checksum="FBEE0839797D1422" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I572</accession>
    <name>A0A1W1I572_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1899"/>
    <dbReference type="EnsemblBacteria" id="SLM48071">
        <property type="protein sequence ID" value="SLM48071"/>
        <property type="gene ID" value="NSJP_1899"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1899"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="286" mass="31337" checksum="CA3DFCEEB0D9D9E6" modified="2017-06-07" version="1">MYRLSYYPWLTQNVPPTEIDRQIRVFASTIASELKSRNHSSPEVEVLPPLDVPEQISQIAENKAEIALMNPLGFIFARRRNNNLSATAVALRIIDGKVGAVYFSQLYTHKKTAIRKLSDVVGKSIGYGVAYSTSNFLIPAFMLKQAGVHPLLSFNRVEFLKGHEVISRAVYEGKVDVGAGHDGVIIDLANQSGYGDAGDVLLQIGRSAPLPSDPVVVNVKDATERKRLQEALVAAGQTELGKIALKIFWGNTQGLEPIDSKAYDGLSDALSTLKLDESDLLRKITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I590</accession>
    <name>A0A1W1I590_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48091">
        <property type="protein sequence ID" value="SLM48091"/>
        <property type="gene ID" value="NSJP_1919"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1919"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="63" mass="7058" checksum="941A29190F3E5AF5" modified="2017-06-07" version="1">MILSVVVTNLGKISHTWLVQSSSHPILDQVVVDVVQSIAPISFKHHSNTPTKTIYVPMTFKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5J3</accession>
    <name>A0A1W1I5J3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Biotin synthase</fullName>
            <ecNumber evidence="3 13">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">bioB</name>
        <name evidence="16" type="ORF">NSJP_2102</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3 13"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2102"/>
    <dbReference type="EnsemblBacteria" id="SLM48274">
        <property type="protein sequence ID" value="SLM48274"/>
        <property type="gene ID" value="NSJP_2102"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2102"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 13 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 13" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="47"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SLM48274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="331" mass="36377" checksum="9B5FDF74A56E3BB7" modified="2017-06-07" version="1">MTDYSALAAKSLDDQVLTRQEALSVLNAPDDELLVLLHAAFQVRARYFGRTVRLQMLQNAKSGACQEDCHYCSQSSISTAPIERYNLLPQNRMIEGARQAAASKAQRYCIVISGRSPLDREIDEIAGAVRAIKQETPIQICCSLGLMSEQQAKRLKAAGVDRVNHNLNTSEAFHASICTTHTFQDRLATIRNARAAGLEICSGGIVGMGEKDEDLVDLAMALREVKPDSIPLNTLHPVAGTPLEHCDNLTPQRCLKVLCLFRFLHPRTEIRIAGGREHNLRSLQPLALYPADSVFVNGYLTTPGAPAPEVWGMIEDLGFKIEVDYQQPVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Y7</accession>
    <name>A0A1W1I5Y7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48414">
        <property type="protein sequence ID" value="SLM48414"/>
        <property type="gene ID" value="NSJP_2242"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2242"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="62" mass="7270" checksum="8AC308C4633D9C3D" modified="2017-06-07" version="1">METLEFAILELRVRALYHIARLKGLKTTAGSIRLLASELSDSEIMSIIQRKNAKWWNLYYWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6B1</accession>
    <name>A0A1W1I6B1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Urea ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_2386</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2386"/>
    <dbReference type="EnsemblBacteria" id="SLM48558">
        <property type="protein sequence ID" value="SLM48558"/>
        <property type="gene ID" value="NSJP_2386"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2386"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017781">
        <property type="entry name" value="ABC_transptr_urea_ATP-bd_UrtD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03411">
        <property type="entry name" value="urea_trans_UrtD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="254" mass="28026" checksum="FC408BB5CC778C70" modified="2017-06-07" version="1">MSERGSIIYLEGVTVDYDGFKALNSLNFIVNFNELRVVIGPNGAGKTTLLDVICGKVKPAAGRVIFGKDTDLIGKREDDIVKLGIGRKFQAPSIYANLTVWENLDLSLKRPSKGVFHTLLSQSTREEQARIHEALATISLEGFSRTRAGSLSHGQKQWLEIGMVILQDPSLLLVDEPVAGMTDKETEQTGILLQSLAARHAIIVIEHDMEFVRQIARIVTVLHEGTVICEGTVEKVQGDARVREIYLGRQKVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6D2</accession>
    <name>A0A1W1I6D2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein NSJP_2372</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhbJ</name>
        <name evidence="2" type="ORF">NSJP_2372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2372"/>
    <dbReference type="EnsemblBacteria" id="SLM48544">
        <property type="protein sequence ID" value="SLM48544"/>
        <property type="gene ID" value="NSJP_2372"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2372"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="287" mass="32509" checksum="4EE7EC658D530557" modified="2017-06-07" version="1">MPGLKLVVISGLSGAGKSHALKSFEDVGYFCIDNLPPALLPPFVELCHQQGGEIRNVALGIDVRERVFFTDLVGVLDRVRALGHSVELLFLEAREEVLVRRFSESRRPHPLLPDLPVLEGVRFEKERLAELRRHADRIIDTSDLTVHELRDLLARQFSQDSVPRRLTISIISFGYKFGVPYDIDLLFDVRFLRNPFFVPELKPLTGEDQRVRAFVLADPDAVAFISHLEQLFKFLIPLFERERRSYLNVAIGCTGGRHRSVSVAKRLQESFAAAGYPSTVVHRDLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6M3</accession>
    <name>A0A1W1I6M3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_2311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2311"/>
    <dbReference type="EnsemblBacteria" id="SLM48483">
        <property type="protein sequence ID" value="SLM48483"/>
        <property type="gene ID" value="NSJP_2311"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2311"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="256" mass="28251" checksum="403359CBC74FF4C9" modified="2017-06-07" version="1">MTPVGAIVAKELRSYFVSPVVYVVGAVFLLIVGLLAYLYIVFAGAQAIQLMQIQGGQAQINLNDLIFRNLFASVRFVLLIILPILTMRLFAEERKLRTFEFLMTSPAGLNEIVAGKFVSVFLVFLGLLAWTSLIPLTLSLFSDFDWHPVLTGYLGLALLGALFLSVGLLASALTENQIVAAFVSFGLLLLLWLLAGMGSLLGDTTAGQIISYVSFMEHYDHLVRGLVDTKDLVYFATAIILLLFLTHRVVDSTRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Q2</accession>
    <name>A0A1W1I6Q2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_2367</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2367"/>
    <dbReference type="EnsemblBacteria" id="SLM48539">
        <property type="protein sequence ID" value="SLM48539"/>
        <property type="gene ID" value="NSJP_2367"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2367"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015221">
        <property type="term" value="F:lipopolysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010664">
        <property type="entry name" value="LipoPS_assembly_LptC-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026265">
        <property type="entry name" value="LptC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06835">
        <property type="entry name" value="LptC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04409">
        <property type="entry name" value="LptC_YrbK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="189" mass="20892" checksum="0635FF06EC00B10B" modified="2017-06-07" version="1">MWRTLAQRGLLGLSVVLACYLVYLLMTNSTAAPPPTRQTGGMDQADATISRFTFTQTKGDKVQWQVDAKQARLFEQKKQALLDTVAVTLFGQAGKELTVEGDEGTLNTDTKNFILANRLEPLVLRTQSGYTIYTNHLSWTDATREIRTGDPVRIVGHGLDVTGVGLLGHMDREEFEVLEDVHVEVSPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Y4</accession>
    <name>A0A1W1I6Y4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2609"/>
    <dbReference type="EnsemblBacteria" id="SLM48776">
        <property type="protein sequence ID" value="SLM48776"/>
        <property type="gene ID" value="NSJP_2609"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2609"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="2">
        <location>
            <begin position="121"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="420" mass="47039" checksum="120A4CA9F307EF59" modified="2017-06-07" version="1">MPMNHDAEANARSRVEEIYRSDSRQVLATLIRLLNDFDLAEEGLHEAFAAAMEQWPRDGMPDNPRAWLVSTARFKAIDVIRRRARFDASLVELARELESRTADQEEEDDDEQIDDDRLRLIFTCCHPALSPEVQAAMTLREVCGLTTEEIARAFLTKPATIAQRIVRAKAKIRDARIPYAVPDETELPDRLDAVLRVLYLVFNEGYSASSGGMVTRHDLSMEAIRLGRLLITLLPQPEAMGLLALMLLQDSRRAARASPNGELILLEDQDRSLWNREQITEGLVLVRQAFSQGQIGPYTIQAAIAAVHAQAPNAAVTDWDQIVRLYTFLSQAEPSPVVDLNRAVAVAMRDGPSSGLALIDAILEKGNLSGYHLAHAARADLCRRLGRTEEARASYQRALSLTQQEPERRFLERRLASLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7C0</accession>
    <name>A0A1W1I7C0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48907">
        <property type="protein sequence ID" value="SLM48907"/>
        <property type="gene ID" value="NSJP_2740"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2740"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="55" mass="6099" checksum="C852AC21F7866E87" modified="2017-06-07" version="1">MEANRFLRAIPNDRTASAVMRAAHEMETAESEVAGPGRRAGGRQAKESRRGRTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7C7</accession>
    <name>A0A1W1I7C7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48948">
        <property type="protein sequence ID" value="SLM48948"/>
        <property type="gene ID" value="NSJP_2781"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2781"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="7"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="112" mass="12196" checksum="01274312109A7213" modified="2017-06-07" version="1">MAGFGLRKHQRFKDSVPVQFRGKGVVGEGRLKDLSLTGASISGDVHVSTGMTLGLQLFFPGDREPLLIDRAIVQWVKGVEFGVELAANPQIAERLTTLISEKVKKRHGPSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7H5</accession>
    <name>A0A1W1I7H5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48972">
        <property type="protein sequence ID" value="SLM48972"/>
        <property type="gene ID" value="NSJP_2805"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2805"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012709512" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="928"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="928"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1070" mass="116810" checksum="30DFC1EC24C36413" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7M7</accession>
    <name>A0A1W1I7M7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_hydro_15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2764"/>
    <dbReference type="EnsemblBacteria" id="SLM48931">
        <property type="protein sequence ID" value="SLM48931"/>
        <property type="gene ID" value="NSJP_2764"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2764"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="54"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="431" mass="49311" checksum="23596C18581FA4D1" modified="2017-06-07" version="1">MPPIVVQNGTLLRYMLDRYDPSSLKRLRRFLERQGVFTFKPLRTHLFPAAIVDRSNRHSGYHHVWVRDNVHVSHALYVHGDARAAARCLSALMEFFSRHRHRFEDVIDGDAAPADIMSQPHVRFDGATLRESREIWAHAQNDALGYFVWMYCLLACRGLLKPTSSDVSVLGMFARYFRAIRYWTDEDCGHWEEERKIEASSIGTVVAGLAKLRELLATGPNRREAAGLSDAELRVLEDRGRTQLRRILPHECIQKTKKRRTDAALLFLVYPLDVVGQAMGKRILADIAERLEGPYGIKRYAGDSYWAADYKEKLSPSERTVDFSDTVEARNALLSPGEEAQWCLFDSIMSAVYGRRFQRTRKPADFVAQTHYFNRALGQLTEPLPGIPAFRCPEAYYLSRGRYVPNDHTPLVWAHANLLVAMKLMETSLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7P9</accession>
    <name>A0A1W1I7P9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_hydro_63 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2869"/>
    <dbReference type="EnsemblBacteria" id="SLM49036">
        <property type="protein sequence ID" value="SLM49036"/>
        <property type="gene ID" value="NSJP_2869"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2869"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="PTHR10412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_63" evidence="2">
        <location>
            <begin position="706"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="911" mass="104666" checksum="03F3FC8DC43A6426" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7R0</accession>
    <name>A0A1W1I7R0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49046">
        <property type="protein sequence ID" value="SLM49046"/>
        <property type="gene ID" value="NSJP_2879"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2879"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="276" mass="30258" checksum="B76F2EBB946E1F04" modified="2017-06-07" version="1">MTERWLRWNTAAGCGVLAIVGLVWSVMLPAAVSAQSPPAPADQGRIKPSEQAVAPEPETYSERVLVKPTEGYIAAFGGYTFGGKFNTDGIGNLAGDSFGNRNLADSGVYGAKAGGFFSDELSWFGVELEAFNTTPNIQQQGAAPGSYMRVTTLAVNAIFRGQFSCTTTTDHTEQVTRRIEMRYEKEFCRLQPYVGIGLGINWTYLQNSNFTARDNFVPGLNVLGGLRYYLTERIGIFTEYKYNRATFDFVSGTGPLTGFQGTYSINHIVAGFSYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7U7</accession>
    <name>A0A1W1I7U7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_2920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2920"/>
    <dbReference type="EnsemblBacteria" id="SLM49087">
        <property type="protein sequence ID" value="SLM49087"/>
        <property type="gene ID" value="NSJP_2920"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2920"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="141"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="218"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="269"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="348"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="483"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="536"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="609"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="794" mass="90229" checksum="4B1D790ADC511E50" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I822</accession>
    <name>A0A1W1I822_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">dnaK</name>
        <name evidence="10" type="ORF">NSJP_2968</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2968"/>
    <dbReference type="EnsemblBacteria" id="SLM49135">
        <property type="protein sequence ID" value="SLM49135"/>
        <property type="gene ID" value="NSJP_2968"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2968"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="513"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="601"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="623"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM49135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="639" mass="69323" checksum="B51887FE18DCD045" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I824</accession>
    <name>A0A1W1I824_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VanZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49167">
        <property type="protein sequence ID" value="SLM49167"/>
        <property type="gene ID" value="NSJP_3000"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3000"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="18"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="160" mass="18032" checksum="BE9E83D3288A7E7C" modified="2017-06-07" version="1">MFARRIHPDLLFAAAWTIVILMVGTLPLKNFVGHSHWEYIKWLPTAQDLRSPAYLLDIASDLIGNTLLFFPLGYFLSRLLNSSKPVRHMLLAGTVGALLSLSIEFYQVYCHSRFPSVFDVVTNVTGTLLGVLIGRSRTKTAMMERNRVLTPTPHNHTLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8C0</accession>
    <name>A0A1W1I8C0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Exopolyphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2942"/>
    <dbReference type="EnsemblBacteria" id="SLM49109">
        <property type="protein sequence ID" value="SLM49109"/>
        <property type="gene ID" value="NSJP_2942"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2942"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030673">
        <property type="entry name" value="PyroPPase_GppA_Ppx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001267">
        <property type="entry name" value="Pyrophosphatase_GppA_Ppx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="333"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="516" mass="57889" checksum="4AB5A0EB2E39D149" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8E6</accession>
    <name>A0A1W1I8E6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphopentomutase</fullName>
            <ecNumber evidence="6">5.4.2.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">deoB</name>
        <name evidence="6" type="ORF">NSJP_2962</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphopentomutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.7" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2962"/>
    <dbReference type="EnsemblBacteria" id="SLM49129">
        <property type="protein sequence ID" value="SLM49129"/>
        <property type="gene ID" value="NSJP_2962"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2962"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043094">
        <property type="term" value="P:cellular metabolic compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16009">
        <property type="entry name" value="PPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010045">
        <property type="entry name" value="DeoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024052">
        <property type="entry name" value="Phosphopentomutase_DeoB_cap_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21110">
        <property type="entry name" value="PTHR21110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001491">
        <property type="entry name" value="Ppentomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143856">
        <property type="entry name" value="SSF143856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="5">
        <location>
            <begin position="286"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="383" mass="40999" checksum="0845E17B482A4590" modified="2017-06-07" version="1">MNRVILFMLGGFGIGALPDADDYADAGTNTLAHLAEASGGVNLPALESLGLGHLGAVRGVRVMAQPSGCFGRLAFRSTGCDSLLGNWELAGCLVTEKATDYSSGYPEKLQSELEQIFGKTLGNQVAFGPSVIRDLGKQHLSSKAPILWSDGHRTCHVAAHDTVLAADQLMRLCREARRALKDPWGIWRVVAHPMTGQPGSWHYKPSRRDFSIEPPAQTMLDVLGRANQILIGVGKVGDLFSGRGFTKTLPSASWTAAFEEVDGMLNRVPRGLIYAGLDLFNDEPAGAAGSLHEFDRRLPHVLEQLRAGDLLVVTGDHGRHLAKKHRLPTREYVPLLVTGPKLAQGVNLGVRSSAADLGQTVVEALLGEPLPVGESFLDALQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8H5</accession>
    <name>A0A1W1I8H5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49159">
        <property type="protein sequence ID" value="SLM49159"/>
        <property type="gene ID" value="NSJP_2992"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2992"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="105" mass="11197" checksum="34BD912043B252BD" modified="2017-06-07" version="1">MDIEAFRQMVAKNPNGFLGRYGLGNKILQEKGSYEEAATHLKVAVQLDPVHVASHFALGRALIGLNKSDEAKSALRAGIDAALSGRSNGGVDLVPEMQALLRTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8P5</accession>
    <name>A0A1W1I8P5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2996"/>
    <dbReference type="EnsemblBacteria" id="SLM49163">
        <property type="protein sequence ID" value="SLM49163"/>
        <property type="gene ID" value="NSJP_2996"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2996"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="253" mass="28826" checksum="23114A82021A1359" modified="2017-06-07" version="1">MADDHKHRARIFLHRGDLLHAREAWEVAADDDRRSGNRRGLSDSLGNLGNTCALLNDLTRAEECYREVLVIQREERDAHAIAHTLVNLGNLHAGTEHPEKSRPYYLEALDMLVELNDHRALGILYNNLALQDAREQQWDQADASFHLALDQHRIVGNEEGLAVTYSQMGKTYLQRGELTGAERCLNNASEHYVRLGHEPAEAAVVRLLASVYEQRGDLVSARRCLERVISIDRRYHLPDEANDVRRLMQLKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8P6</accession>
    <name>A0A1W1I8P6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TNase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49239">
        <property type="protein sequence ID" value="SLM49239"/>
        <property type="gene ID" value="NSJP_3072"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3072"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="110" mass="12206" checksum="B892CFCA4E5C11AF" modified="2017-06-07" version="1">MSVYPASRAAAVRQSNLGLGLRIDTPEICGKCDRKKSSTRKAQAVTSQLLNQAKQIESFEIRRDKYFRFLAGLRLTGRALLDAGLAVPHTGAPRRPSGVLNPSRHRLEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Q8</accession>
    <name>A0A1W1I8Q8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="3">2.7.8.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pssA</name>
        <name evidence="3" type="ORF">NSJP_3227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3227"/>
    <dbReference type="EnsemblBacteria" id="SLM49394">
        <property type="protein sequence ID" value="SLM49394"/>
        <property type="gene ID" value="NSJP_3227"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3227"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="198" mass="21280" checksum="55136D99316FC19A" modified="2017-06-07" version="1">MIREFHLADFLTLANAACGVGAVLFSMRYMGSGASADFLTAAALVPGALLFDWLDGRVARWRHEHTALGRELDSLADILSFGMAPAALGYAAGLRGGWDWFALTFFVCCGVSRLARYNVTAEQLSAGGDKVAYFEGTPIPTTVLLAGLLAILLWQDRLGERLYGGVWTIGVADLHPLSLLFVLSGSLMISKTLKIPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8S9</accession>
    <name>A0A1W1I8S9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49203">
        <property type="protein sequence ID" value="SLM49203"/>
        <property type="gene ID" value="NSJP_3036"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3036"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="90" mass="10301" checksum="666D5BB948CF020D" modified="2017-06-07" version="1">MGRSVPVAGDGEQTNTLKMRTVYMDAKPPQWRDFSLMGVPSTSWSFARKSFVVNHWFSVLIWETLTGPNYWANSHARYHASPPIDYGEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Y8</accession>
    <name>A0A1W1I8Y8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">clpX</name>
        <name evidence="9" type="ORF">NSJP_3299</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ClpX chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3299"/>
    <dbReference type="EnsemblBacteria" id="SLM49466">
        <property type="protein sequence ID" value="SLM49466"/>
        <property type="gene ID" value="NSJP_3299"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3299"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="123"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="8">
        <location>
            <begin position="327"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="132"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="423" mass="46550" checksum="390FE692A2ED7814" modified="2017-06-07" version="1">MFWDRVHPSPEPRPVCWFCGRSETTVRNLVASPVEHSCKSCGVISKVLICEECLQRSLNRDRIGQPSTSSSLPSVIPKPTDIKATLDEFVIGQERAKKVLAVAVHNHYKRIVNRDRLKHVGLQKGNILMIGSTGTGKTLLSQTLARILHVPFAIADATTLTEAGYVGEDVENVVLKLLQNCDYDVPRAETGIIYIDEIDKISRKSESPSLTRDVSGEGVQQALLKLVEGTTCNVPQKGGRKHPEQEFIRVDTTDILFIAGGAFVGLDHIIAERTMPKRLGFDMHDPSVGIDGHTEILGRVRSEDLLKFGLIPEFVGRFPVLTTLADLDVPALIRVLTEPRNALVKQYQALFEIEGVELTFSDSAVRAVARRAALMKTGARALRTILEEVMLDLMYEVPAMGSVKSVEITEDVIAGTAQPRVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I995</accession>
    <name>A0A1W1I995_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein, Hsp20 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3430"/>
    <dbReference type="EnsemblBacteria" id="SLM49597">
        <property type="protein sequence ID" value="SLM49597"/>
        <property type="gene ID" value="NSJP_3430"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3430"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="37"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="149" mass="17003" checksum="01D0C879AE6DF921" modified="2017-06-07" version="1">MALVRWDPFRELEDMSERLNRMFARPAPRTGNGKEALTVADWMPTVDISETDGEYLIKAELPEVKKEDVKVTVEDGVLTLQGERRQDKEEKGKKFHRVERSYGSFVRSFTLPESVDDTAVKAEYKDGILALHLPKTERVKPKAVDVKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9F9</accession>
    <name>A0A1W1I9F9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="8">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="8">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ImGP synthase subunit HisH</fullName>
            <shortName evidence="8">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">hisH</name>
        <name evidence="11" type="ORF">NSJP_3469</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="8"/>
    <dbReference type="EC" id="3.5.1.2" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3469"/>
    <dbReference type="EnsemblBacteria" id="SLM49636">
        <property type="protein sequence ID" value="SLM49636"/>
        <property type="gene ID" value="NSJP_3469"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3469"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000495-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM49636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="202" mass="22167" checksum="F224AEE77DF6FE10" modified="2017-06-07" version="1">MIAIIDYGMGNLRSVSKAFEAVGHRAVVTRNTRVIDDASRVVLPGVGAFGDCMANLERYGLVQSIRKSVQSGKPFLGICLGLQLLFTESEEFGRHEGLGIIPGRVRRFAAGPAVKVPHMGWNQVTLRTDCPLFDGVGDGADWYFVHSYFVEPVDPSIIATTTTYGISFASSIWRDNVVACQFHPEKSQSVGLRLMRNFGGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9V4</accession>
    <name>A0A1W1I9V4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3492"/>
    <dbReference type="EnsemblBacteria" id="SLM49659">
        <property type="protein sequence ID" value="SLM49659"/>
        <property type="gene ID" value="NSJP_3492"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3492"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043878">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044638">
        <property type="entry name" value="ALDH7A1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521">
        <property type="entry name" value="PTHR43521"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="6">
        <location>
            <begin position="36"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="511" mass="55011" checksum="04FFDCC5F97A5C0B" modified="2017-06-07" version="1">MSNAQDILRELGIQGTNAGGSTGSGRWCGPGNAPLLQSINPATGDPIAGIHPCRLPDYERILKDSLEAFQRWRLVPAPKRGEVVRQIGQMLRDKKDPLGTLVSLETGKIKAEGEGEVQEMIDMADLAVGQSRMLYGATMPSERPAHRLSEQWHPLGPVGVITAFNFPVAVWAWNAFLAAIAGDTIVWKPSPKAPLCAIAVQHICNRVMEQQGLSGIFSLFVTDQQSLAETMVQDRRLPLISFTGSVTVGRHVASLVGQRLGRTLLELSGNNAVIVDETADLDLATRAIVFGAVGTAGQRCTTTRRLFVHESRADELIAKLVKGYGQIPIGNPLEPNVLMGPVIDRTAVEAYRQAIEEIKTEGGQILYGGKVLPRAGHFVEPTIVRAHNHWPVVQRETFAPILYVMSFHSLDQAIELQNSVPQGLSSAMFTTNLRHGERFVSAAGSDCGIANINIGTSGAEIGGAFGGEKETGGGREAGSDAWKAYMRRQTNTVNWGTDLPLAQGIKFGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Y7</accession>
    <name>A0A1W1I9Y7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3643"/>
    <dbReference type="EnsemblBacteria" id="SLM49810">
        <property type="protein sequence ID" value="SLM49810"/>
        <property type="gene ID" value="NSJP_3643"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3643"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="99" mass="11079" checksum="1C699ECD0F427708" modified="2017-06-07" version="1">MPDNRVRVLARVTAKTSSVEQVRAILIALVDATRKEPGCISYEFLQNRSDPQEFVSVEEWESAVDEQAHFATEHLKNAIVGLTGHLAAEADIRRYSAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Z5</accession>
    <name>A0A1W1I9Z5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49844">
        <property type="protein sequence ID" value="SLM49844"/>
        <property type="gene ID" value="NSJP_3677"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3677"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="97" mass="10577" checksum="E94C9140E653B193" modified="2017-06-07" version="1">MVIAVVVVFSMMSDIEMWLYVAIIIGLVASVAVGRTSGKPDEFPLQPRLLKFAKGWTLVVALAALSVLHGKWQPMVFFAILGTLSSAFFWVGCRSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA45</accession>
    <name>A0A1W1IA45_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49894">
        <property type="protein sequence ID" value="SLM49894"/>
        <property type="gene ID" value="NSJP_3727"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3727"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013343136" evidence="1">
        <location>
            <begin position="23"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="130" mass="13811" checksum="215CDA4290BB195C" modified="2017-06-07" version="1">MVQSSKGIIVASILSGAIGGFAASTLTGVPGHAEPSDQTTFQVVRAQEFQLVDGKGRTRGVMAFSADGQPYLQLRDEQDISGVWVGIARDTGVAVRDKDGKTRLVLSVDDAGSPSLVVRNRDHQTRSFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA51</accession>
    <name>A0A1W1IA51_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3476"/>
    <dbReference type="EnsemblBacteria" id="SLM49643">
        <property type="protein sequence ID" value="SLM49643"/>
        <property type="gene ID" value="NSJP_3476"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3476"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013094118" evidence="1">
        <location>
            <begin position="34"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="411" mass="41322" checksum="D339A79B506C5846" modified="2017-06-07" version="1">MTALIASAPRPSFRLLQRSLRLVLGVLSLSVMAGCNDVSEAPAPDPGPGALTIVTASLPDATVRQPYSITIGGSGGITPYSWGVTPPLPANLSFNGASGAISGMPAAQGTSSHTFTLQDSSVPPQTTQKTLSLKINQALVPPAITTLSLPAGTVNAPYPQTTLNATGGVPPLVWQPVGMPFGLTFDAASHSISGVPTSSGTANVTFTVNDSAVPFNQTASGTLSITVNVALKIDTTSLPEGSVNQGYGPVQLNASGGGQPYSWTIVGGAPPAPGLTLSSGGVITGQPTTKGAFTNTYRVQDNNGAAVTQSLTITVAELIIDTTGLPTGRVGVAYGPVALTASGGTPPYVWSSSVVPVLPSGLLFDPNSGTVSGAPLVPQINGSHTFSVRDAANRTATKALGLTILDSLTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA86</accession>
    <name>A0A1W1IA86_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Asparagine synthetase</fullName>
            <ecNumber evidence="9">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_3801</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49968">
        <property type="protein sequence ID" value="SLM49968"/>
        <property type="gene ID" value="NSJP_3801"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3801"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="364"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="650" mass="73373" checksum="EB3DFC3FB40FCFDC" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAB9</accession>
    <name>A0A1W1IAB9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3694"/>
    <dbReference type="EnsemblBacteria" id="SLM49861">
        <property type="protein sequence ID" value="SLM49861"/>
        <property type="gene ID" value="NSJP_3694"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3694"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013275123" evidence="1">
        <location>
            <begin position="26"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="242" mass="26147" checksum="D32BCCC31D897C1A" modified="2017-06-07" version="1">MPFVRYQRCLAAVSFIATGIALLLAFPPDGSGTEPSFRHEPAMHLVAGKQPPSVDEPPVAEGIVDRYLVHPRGIVDGLLLRDGAQMHVTPRAAEGLIQIIQPGDHVRVHGRRGANSPLVTPDVIVNVTDGKSFTIPYRLDLPIPPAEARPTANEMRAAGTIEVLLYDYIKGGVNGMLLSDETQVRLPPDVGRDFPASLRPNMDVEVEGHGTTTRYGRALEATAIGRKGHPLTPLDASIQQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAC9</accession>
    <name>A0A1W1IAC9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyltransf_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3789"/>
    <dbReference type="EnsemblBacteria" id="SLM49956">
        <property type="protein sequence ID" value="SLM49956"/>
        <property type="gene ID" value="NSJP_3789"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3789"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="158"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="356" mass="40567" checksum="02B192934BC9427B" modified="2017-06-07" version="1">MAYRIERIDARANDWALTTDNHQERTIYQTRTWLTFLSETQGGEPVIGALKDGRSTVGYFTGLIVTKLGLRILGSPFPGWSSDYMGLNLSSGAIRTKAIQALIDFAFHDLGCVHLEMMDRSITVRDLHDLKTQHRIYTSYEIDLTRDENALFMNMTSACRRCIRKAGKAGVSIEQAHDSAFADEYYEQLGDVFARQRLVPPYKVERVRRLIEHILPTGNLLLLRARDRSGRSIATGIFPHLNGLMYFWGGASRREDRLLRPNEAIQWHAMKIGKQLGNQLYDMGGGGEYKRKYGGTTIQVPWFRISKYAWVRCAREIAQRGHAVAQHFQGRLGNLLTPSEFRAGRVKVHSQSQTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAF7</accession>
    <name>A0A1W1IAF7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3870"/>
    <dbReference type="EnsemblBacteria" id="SLM50037">
        <property type="protein sequence ID" value="SLM50037"/>
        <property type="gene ID" value="NSJP_3870"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3870"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="75" mass="8581" checksum="B5C9D3FF4BF5AE93" modified="2017-06-07" version="1">MDPETFRRICMVFDGLVVGFGLSRVVRELDLASSLTTYGILTIVILINAYLLFRFFRDWDREFPPVSTSSTSLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAI8</accession>
    <name>A0A1W1IAI8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="3">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3764</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fabD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3764"/>
    <dbReference type="EnsemblBacteria" id="SLM49931">
        <property type="protein sequence ID" value="SLM49931"/>
        <property type="gene ID" value="NSJP_3764"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3764"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="5">
        <location>
            <begin position="5"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="286" mass="31131" checksum="E93531C177627D06" modified="2017-06-07" version="1">MLVVAFAGQGSQRAGMGSTLFPRYRDVVNCANRILGYSLQDLCAAGGPRLTRTEFTQPAVFVVNKLLYEDTLANDGIVPDVMIGHSLGEINALHATGVLDFEEALQLVKARGAFMAEHNGNGAMVALVGERDQLLHEVSTNESEVYVANDNSPRQIVVAGTKDGIKRLSQRLSLQQAATVIPLAVSGPFHCPLMAGVDDRMGEYLEGCLLREPCIPVVSNYSAQPYRSDVMRTWLAKQVVSTVRWLETIQYLSGSGPLAVREIATSPVLTPLIEDCLKRMRESVMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAM7</accession>
    <name>A0A1W1IAM7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cyclic peptide transporter</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NSJP_3907</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3907"/>
    <dbReference type="EnsemblBacteria" id="SLM50074">
        <property type="protein sequence ID" value="SLM50074"/>
        <property type="gene ID" value="NSJP_3907"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3907"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005898">
        <property type="entry name" value="Cyc_pep_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43553:SF11">
        <property type="entry name" value="PTHR43553:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01194">
        <property type="entry name" value="cyc_pep_trnsptr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="14"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="337"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="374"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM50074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="565" mass="62099" checksum="3DA2B514EBFF0E34" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAM9</accession>
    <name>A0A1W1IAM9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-54 dependent transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_3885</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3885"/>
    <dbReference type="EnsemblBacteria" id="SLM50052">
        <property type="protein sequence ID" value="SLM50052"/>
        <property type="gene ID" value="NSJP_3885"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3885"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="143"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM50052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="463" mass="52034" checksum="9E224F2A763CA096" modified="2017-06-07" version="1">MNATIFVTDDEPAIRSALVKRITRRNHRVTAFASGEDLVQALDHEVPDLLLLDVKMPGLSGLEALKICRQKAPFSLVIMLTAYGTVQDAVEAMKLGAYDFVIKTVDLEGVEQVLDRALELLALRRRMSFQSEQDMGQYALTELIADSNAMQVLLAQIREIAHNPKSTVLMLGETGTGKEFVARVLHHNGSRSAGPFIGVNCTAIPRELFESELFGYERGAFTGANQRKLGLLDRAESGTLFLDEIGDLDLGMQAKLLRVLQERTFRRLGGTDDIAVDFRLIAATNRDLKKEIAAGSFREDLYFRLNVVALELPPLRQRTEDILPLCMKALLHYGKEFGKDVTDIDQETRALLERYSYPGNIRELQNIIERAMIFCQGRTLTANYLPRELHDQAKQTTTTVVRGEAPLIRVEMEVGKQTLAEIEESVIEETLRLADYNKSLAAKQLGLTRFALDRRLKKIDKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAN0</accession>
    <name>A0A1W1IAN0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Multi-domain non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3899</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3899"/>
    <dbReference type="EnsemblBacteria" id="SLM50066">
        <property type="protein sequence ID" value="SLM50066"/>
        <property type="gene ID" value="NSJP_3899"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3899"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
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        <property type="project" value="UniProt"/>
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    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
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        <property type="project" value="UniProt"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_adenyl_domain"/>
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        <property type="entry name" value="AB_hydrolase"/>
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        <property type="entry name" value="ACP-like_sf"/>
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        <property type="entry name" value="AMP-bd_C"/>
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        <property type="entry name" value="AMP-bd_C_sf"/>
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        <property type="entry name" value="AMP-binding_CS"/>
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        <property type="entry name" value="AMP-dep_Synth/Lig"/>
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        <property type="entry name" value="CAT-like_dom_sf"/>
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        <property type="entry name" value="Condensatn"/>
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    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="1047"/>
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        <location>
            <begin position="2043"/>
            <end position="2118"/>
        </location>
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    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1007"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM50066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="2401" mass="261478" checksum="D7A9F2C62012C192" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAR3</accession>
    <name>A0A1W1IAR3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49989">
        <property type="protein sequence ID" value="SLM49989"/>
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    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3822"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="379" mass="40952" checksum="B1A9F0C59FF93E86" modified="2017-06-07" version="1">MSVSERYDSNVWFAPRSLVPADLPLDDFVTTLSPRLEIKSKSEKRVDATLSAGGTANMFAYNKDLGFLSTDVAGVANLDGWVSQVFRGSTLKLSDTFLYTPEPPAFVTGGTTSAPADTFSRGIQAFRANTFSNIASAVATFQMMDTVDLKGQYTNSIFTVGTLFVTGPTGGVGFFDTKVNDWALGPSLHLSRGDTLSLSYRQYQLSQTGAGPTLNFLARGGELEYNSKLAPGWITKVAAGVKVVEPGNSAFATGRFEVTHALEQNVQLQVRASRDIAPAFFGTGGALVSNTASVFVVHRFARDVSLLGSGNAGYSETTPIKGTKYYSYGASGELRYMFLRDTFASLSYTYTYFDLNQVGALPYLVERSVVMLSVQAMWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB12</accession>
    <name>A0A1W1IB12_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_4037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50204">
        <property type="protein sequence ID" value="SLM50204"/>
        <property type="gene ID" value="NSJP_4037"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4037"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="47" mass="5277" checksum="9FA26DE75654A4F1" modified="2017-06-07" version="1">MLEVAGTSEVSTNIFMIYVLLNHCTRRIHLGLHDNTNRAAVSPIRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB29</accession>
    <name>A0A1W1IB29_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_4039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NodU/CmcH family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4039"/>
    <dbReference type="EnsemblBacteria" id="SLM50206">
        <property type="protein sequence ID" value="SLM50206"/>
        <property type="gene ID" value="NSJP_4039"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4039"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031730">
        <property type="entry name" value="Carbam_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038152">
        <property type="entry name" value="Carbam_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003696">
        <property type="entry name" value="Carbtransf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16861">
        <property type="entry name" value="Carbam_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02543">
        <property type="entry name" value="Carbam_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbam_trans_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_C" evidence="3">
        <location>
            <begin position="407"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="615" mass="69667" checksum="3DF92E909EEE3C8E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB41</accession>
    <name>A0A1W1IB41_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_4067</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4067"/>
    <dbReference type="EnsemblBacteria" id="SLM50234">
        <property type="protein sequence ID" value="SLM50234"/>
        <property type="gene ID" value="NSJP_4067"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4067"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_31" evidence="3">
        <location>
            <begin position="564"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="759" mass="85326" checksum="CA208B0C377FB6BC" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB55</accession>
    <name>A0A1W1IB55_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4065"/>
    <dbReference type="EnsemblBacteria" id="SLM50232">
        <property type="protein sequence ID" value="SLM50232"/>
        <property type="gene ID" value="NSJP_4065"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4065"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10941">
        <property type="entry name" value="CE4_PuuE_HpPgdA_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045235">
        <property type="entry name" value="CE4_PuuE_HpPgdA-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022560">
        <property type="entry name" value="DUF3473"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014344">
        <property type="entry name" value="PEP-CTERM_polysacc_deacetyl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11959">
        <property type="entry name" value="DUF3473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03006">
        <property type="entry name" value="pepcterm_polyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="31"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="296" mass="34190" checksum="557A3163BA805934" modified="2017-06-07" version="1">MNSAKSALHHGLSFDVEEHFQVSAFWSENRRQQWDSLESRVENNTRRIADILAAHDMKATFFVLGWVAERHPELIRSLSLEGHEIASHGYSHELVTTQTPESFRADIRKAKQILENAIGKPILGYRAPSFSITNETRWALEILVEEGYVYDSSVFPIVHDRYGMPGAEPHCHRLATKAGFLWEVPPSTIEVFGLRWPVAGGGYFRLIPYIILRRFLKRIERARQPLVMYLHPWELDPAQPRMEGSLLSRFRHYNNLHKTEPRLVSLLSEFRFGPIQRLIEGMEHSHRESLQSAVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBA9</accession>
    <name>A0A1W1IBA9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_4034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4034"/>
    <dbReference type="EnsemblBacteria" id="SLM50201">
        <property type="protein sequence ID" value="SLM50201"/>
        <property type="gene ID" value="NSJP_4034"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4034"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="416" mass="45319" checksum="C002843E4857F763" modified="2017-06-07" version="1">MKLQRTLAPTSAPLSLSNLIGSLPGLIGGRKYRERLIRELEAKFQARGVFLVSSGKAALVVVLKALAASSRRRRVIIPAYTCFSVPSAIVRAGLEVVLCDVNPRTLDFDFEELERLLSEDILCVLPTHLFGLPADVRRVVQLCRTRDIAVVEDAAQALGGGSEKGLVGTEGDVAFFSLGRGKNLTSGTGGIIVTKSPTLADAIHAEYSKLPAASFGETCRNWAELVLMRAFIRPTWYWLPSGLPFLGLGETKFYTDFPVCRMDEVRACQLVGWDRRLAKANTDRAACAGKLIMGLNQGFNGLQPITHPDGVYLRLPVLLRDRVAKHEACARSQKYGAGVSSSYPTTIQDIPELAGRITDRTCPGAQEVVERLVTLPTHEFVTESDRVKIWRVLGVSEPRSRNTGARSAPVDQCSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBQ7</accession>
    <name>A0A1W1IBQ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_4036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4036"/>
    <dbReference type="EnsemblBacteria" id="SLM50203">
        <property type="protein sequence ID" value="SLM50203"/>
        <property type="gene ID" value="NSJP_4036"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4036"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="363" mass="40460" checksum="4F862897F85764E4" modified="2017-06-07" version="1">MFLNDPTAARVFARVEVLPDPPRPTWWGQQWHRMNLAAFFETRYRQPSYYRMMREKIDALCIEAKVDLIYADLIFMTEYVGEHRAIPAIVDLTDSITLMGLRVLRSEHGLSKKLSAWAHLVRARQLERTVGNVFDLVVTNSVVDEGVIKGLSGSSNTLTVTNGVDMDYFLPGIGQGETDKLVFTGVMGYPPNQDAALYFSDEIFPLIRAKRPHAQFWIVGNGPPENVRRLAQRPGIHVTGEVEDVRPFVRSSALVVCPLRLGTGVKNKILIAMAMKKATVATPLSIEGLDLVDNREVALADSAQVFADKVVHLLENPTEAQRLGANGLARVREHHSWAVMARSLEMAIDSVIVSRNGRSHPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZS0</accession>
    <name>A0A1W1HZS0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">ffh</name>
        <name evidence="9" type="ORF">NSJP_0062</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0062"/>
    <dbReference type="EnsemblBacteria" id="SLM46234">
        <property type="protein sequence ID" value="SLM46234"/>
        <property type="gene ID" value="NSJP_0062"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0062"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="8">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="448" mass="48894" checksum="EA08C5A8287F047C" modified="2017-06-07" version="1">MLDALSEKFEKILKKLRGSGVLTEQNIAEAMKEVRLALLEADVNFKIVKDFVERVGKKAVGQEVMQSLTPGHQVVKVVWDELRAMMGGEKAGLALSSAPPTVVMMVGLQGAGKTTTCGKLARFFKQQGRRVLLVAADPRRPAAGDQLASLGRDLQIDVHRQDQAGASQTDVVRICQDGVRRGTDQGFDVVVLDTGGRLHVDDELMGELVAVKAAVKPHEVLLVADAMTGQDAVNMATQFHERVGVTGIILTKVEGDARGGAVLSIRAVTGQPIKFLGVGEKLDALELFHPDRMASRILGMGDVLSLIEKAQETFTREQAEEAQKRLTSNTFTLEDFRAQLAQVNKLGSLDQILGMLPGGQKLRGAMEGQVPEREMKRVVAIIDSMTRRERRDHTLINGSRKKRIARGSGTNVMEVNRLIKQFLSARKLAKMLTGASGRRQLAQLLNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZT3</accession>
    <name>A0A1W1HZT3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Cell division ATP-binding protein FtsE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ftsE</name>
        <name evidence="8" type="ORF">NSJP_0055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms a membrane-associated complex with FtsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0055"/>
    <dbReference type="EnsemblBacteria" id="SLM46227">
        <property type="protein sequence ID" value="SLM46227"/>
        <property type="gene ID" value="NSJP_0055"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0055"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005286">
        <property type="entry name" value="Cell_div_FtsE_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02673">
        <property type="entry name" value="FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="222" mass="24429" checksum="B40221FFB2D0F879" modified="2017-06-07" version="1">MIELIRVSKQYDRRPALSNVTLEIEKGEFVLLMGASGAGKSTLLRMLIGAERPDDGQVFVYGKNVTALKQGDIPYLRRKVGTVFQDFRLLAKKTVFDNVALPLLVQGISAQDIRRKVTEALRAVGVEHKRDQLPMVLSTGEQQRVCIARAIVNGPVVLLADEPTGNLDPGLTAEIIELFKLINARGTTVVVATHDPQVMTQVNRRVITLSHGTLTPEKWVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZV2</accession>
    <name>A0A1W1HZV2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46286">
        <property type="protein sequence ID" value="SLM46286"/>
        <property type="gene ID" value="NSJP_0114"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0114"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="67" mass="7653" checksum="430BCD03C67C9AF3" modified="2017-06-07" version="1">MHVVEELVVFRVQQAPRYEKVNLAAIEGTFDGGRVFDRRRGRDDGRSGSGGILYRLFTRHMRISSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZV7</accession>
    <name>A0A1W1HZV7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46288">
        <property type="protein sequence ID" value="SLM46288"/>
        <property type="gene ID" value="NSJP_0116"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0116"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="332" mass="38973" checksum="AA912E714789C7EA" modified="2017-06-07" version="1">MELRFQPALLQEVIDSFVEKTEREGDPTYYKEFHELADPIYEKFTLDDRESEFKKLYQYLFGTWGFSDIIRDAFNEYPVLKDQVGIVLVKGVLKEDQEGVDILRKWGSVEHELAKRFEEKGLKGVGIKLIPRRFYDPALTRYCRHELMHISDMLSPQFSYDPDTKVGQNPGEETLILQRYRVLWSLSVDSRLMATGKEPMLRKEDRFKEFRSWYRKIPAPQLKSVFEGLWQTGFFTHSELIEMATDTLRVMDRAVDVEGGEVPETENKVMLMPGFPCPLCRFPTYSWVEDLGHKLETYVLDFIRENHPGWDVEFGACDRCVEVYKLRADGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I006</accession>
    <name>A0A1W1I006_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Proteasome-associated ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">arc</name>
        <name evidence="6" type="ORF">NSJP_0047</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0047"/>
    <dbReference type="EnsemblBacteria" id="SLM46219">
        <property type="protein sequence ID" value="SLM46219"/>
        <property type="gene ID" value="NSJP_0047"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0047"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02112">
        <property type="entry name" value="ARC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041626">
        <property type="entry name" value="Prot_ATP_ID_OB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022482">
        <property type="entry name" value="Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17758">
        <property type="entry name" value="Prot_ATP_OB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03689">
        <property type="entry name" value="pup_AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="271"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="36"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="589" mass="65566" checksum="84C09791ECAF9FB0" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I048</accession>
    <name>A0A1W1I048_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Glutamate synthase, large subunit</fullName>
            <ecNumber evidence="17">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">gltB</name>
        <name evidence="17" type="ORF">NSJP_0208</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="17"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0208"/>
    <dbReference type="EnsemblBacteria" id="SLM46380">
        <property type="protein sequence ID" value="SLM46380"/>
        <property type="gene ID" value="NSJP_0208"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0208"/>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="16">
        <location>
            <begin position="23"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="907"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SLM46380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1506" mass="165902" checksum="A1C5F98B05A4149E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0F2</accession>
    <name>A0A1W1I0F2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46452">
        <property type="protein sequence ID" value="SLM46452"/>
        <property type="gene ID" value="NSJP_0280"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0280"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="110" mass="12480" checksum="8543262220C3E005" modified="2017-06-07" version="1">MTRRNGDWVQGLGLAATVLALSSLVVMDGLSWTSAPAYAGDRGEQRRDKRDDRQDDRQDARDTRQEGREAAKDAKEECKKADDKSNAECRREKRDAKDDARDAARDIRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0H1</accession>
    <name>A0A1W1I0H1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0171"/>
    <dbReference type="EnsemblBacteria" id="SLM46343">
        <property type="protein sequence ID" value="SLM46343"/>
        <property type="gene ID" value="NSJP_0171"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0171"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="500" mass="56346" checksum="189B35120E9585A5" modified="2017-06-07" version="1">MPNRSAGEVGHAVALNALLLLFLVNFTLQPLTEPDFGWHLRTGLDLLHNGLPLPALDPYSHTMPDWPWVEHAWLTDAIIGALYASWMGGLGVIVLFGAVATGAWLIAAGAASVPRSARWLAATLSIWVALPYLGARTQLVSWLGLAVLLRLLSNPAGASQRWIPLLFLVWANLHGGFVMGLVLMSVVACALWVMRWLHAKRAFRFSPADESGFAQWDLRRLVLLTAASALMTLVNPYGWRLHGEIIDSLANQFMVDELQEWQPLSLATTAGRGYVLYLAALSAAMGCWYRRYEPVRWIIWIAFLWFSLRHMRNVPVFLVISLPLAAELTAAAFDWLNRGLGAAAMRHAMLAGAILAALLLIWEGPDHLHHVVQSGTDPARYFRTTSYPIEAVEWIRTHSAQTGARIYNDYGYGGFLLWWMPEHKIFIDGRMPAWRIGNRRIFQDYVALTRGEPVDLSVLEKYAVDWALVRRETPLDRALYRETKWVRVYEDEKVSLYVMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0J5</accession>
    <name>A0A1W1I0J5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46525">
        <property type="protein sequence ID" value="SLM46525"/>
        <property type="gene ID" value="NSJP_0353"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0353"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="99" mass="10467" checksum="C0C75F4A50265111" modified="2017-06-07" version="1">MGQSNDNDAGRANRLAMAAALALLGASVGVDVPTVLASSSPSPMPPEGMRQSGDRMKPDATQQKFDPAQKRMDATQQKHPSVQQKDMVAPGMKPIPPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0K1</accession>
    <name>A0A1W1I0K1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46507">
        <property type="protein sequence ID" value="SLM46507"/>
        <property type="gene ID" value="NSJP_0335"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0335"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="62" mass="6591" checksum="7600FC580F0F2DE5" modified="2017-06-07" version="1">MSNVATPACLARAVEKPAEPGKTANPDDFSTRAVRVGREARASPENGHQRDGCFRGGSHPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I117</accession>
    <name>A0A1W1I117_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alkaline phosphatase synthesis transcriptional regulatory protein PhoP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">phoP</name>
        <name evidence="6" type="ORF">NSJP_0502</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0502"/>
    <dbReference type="EnsemblBacteria" id="SLM46674">
        <property type="protein sequence ID" value="SLM46674"/>
        <property type="gene ID" value="NSJP_0502"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0502"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="133"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="133"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="234" mass="26409" checksum="654E53DE68BCB9A3" modified="2017-06-07" version="1">MFAGKKILIVEDEKDILHLVKLYLDKEGFRTLTAANGIDALRQTRSEHPDLVILDLMLPEIDGLEVCKKLRLTPQTAMLPIIMLTAKSEESDMVVGLELGADDYVTKPFSPRGLVARVKALFRRLARANDREISTYQYGSLHLNLSRHEVTVDGQEVPLTAKEFGLLEHLLRNPGRVLTRDVLLNNVWGYDYHGTTRTVDVHVRRIKQKLPLLNDAILSVKSLGYKLKDLSMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I179</accession>
    <name>A0A1W1I179_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiol oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_0583</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0583"/>
    <dbReference type="EnsemblBacteria" id="SLM46755">
        <property type="protein sequence ID" value="SLM46755"/>
        <property type="gene ID" value="NSJP_0583"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0583"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010538">
        <property type="entry name" value="DHOR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06537">
        <property type="entry name" value="DHOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="332"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="466" mass="49732" checksum="CDC79CE9566A1BF2" modified="2017-06-07" version="1">MLSPTPQWTRLLAISVVMVSVSAGFLLQDGHSQTARITARDPGVRTGPAGSGQMLSGLTALEQRLFSNSRAVFQEVQSVQGTIANTEAGLGPRFNLDSCAGCHSNPDVGGSSPAVNPQVDVAKKEGAVNEIPSFIKRDGPIREARFKLGPGGTPDGGVQALFTITGRHDAAGCSLPQPDFRTAVAARNVIFRIPTPLFGSGLIEAIDDDTILANIAANSPTKQSLGIVGRANRTTGHPNTSGNDGTITRFGWKAQNKSLEVFSGEAYNVEQGITNDLFPHEREELKSCYFNATPESSTHYEALDPIEVPSDVVKFAVFMRLLAAPTPAADTDTVTRGRKLFGDTGCAFCHTPTLHTGKAVVASLRNKEANLYSDLVLHNMGTGLADDVSQGAARGDEFRTAPLWGLGKRVFFLHDGRTKDLLEAIQAHASGGNGQYAASEANQVIAQFNRLNEIDKQHLLNFLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1A4</accession>
    <name>A0A1W1I1A4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional dual regulator HU-beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hupB</name>
        <name evidence="2" type="ORF">NSJP_0592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46764">
        <property type="protein sequence ID" value="SLM46764"/>
        <property type="gene ID" value="NSJP_0592"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0592"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="95" mass="10372" checksum="74C8FC3227034198" modified="2017-06-07" version="1">MAKSMTKSQIADHLAQKSGLTKKAAVQLLDDFAALAYREAKNVFTVPGIGKLKLANRKARIGRNPQTGEEIKIPAKRVVKFRVAKVAKDSILGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1H0</accession>
    <name>A0A1W1I1H0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ketoacyl_synth_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0659"/>
    <dbReference type="EnsemblBacteria" id="SLM46831">
        <property type="protein sequence ID" value="SLM46831"/>
        <property type="gene ID" value="NSJP_0659"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0659"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13723">
        <property type="entry name" value="Ketoacyl-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoacyl_synth_N" evidence="1">
        <location>
            <begin position="38"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="261" mass="27916" checksum="34CCA8C39FE04B39" modified="2017-06-07" version="1">MNVDVLGIGILGPGLEDWPAARSILTGLMPHTVRPTVKPIPHILPNVERRRSSEAARLTIKVADDALTMSDLPRDEVATVFTSSDGDGDITDKICESMAGSPGGVSPTLFHNSVYNAPAGYWSIGTGSRRSSTSLCAFDYSFAAGLLEAAAHTTIEQEAVLLVGYDLPFPEPLRAVRNVAHSLAVAFVLAPPRYGASLMRWWIELESPRPQTGIPDAIDRAVHANPMARSFPLLSVLASGQPQSIVLDYSNEQSLVVACEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1H7</accession>
    <name>A0A1W1I1H7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Regulatory protein, MerR family, Cobalamin B12-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0670"/>
    <dbReference type="EnsemblBacteria" id="SLM46842">
        <property type="protein sequence ID" value="SLM46842"/>
        <property type="gene ID" value="NSJP_0670"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0670"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="177"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="306" mass="34172" checksum="FE1D96908650CFCB" modified="2017-06-07" version="1">MNVHRIHRVAKLTGLSKDVVRVWERRYGLVKPSRSANRYREYTDEEVALLRFLKEELDRGQTIGTLAAEGRSSLLQRMRSSSPPTALELKPHEHLLDELALLLDPLDKTRFEQKINGAIAVIPFEEAVQRILLPLQRRVGELWHEGTLNVAVEHYVTKIIQQKFFSVINQLPVNDAGPRVVIACPEGEFHEIGAQAVAYLAAIRGCQVYYLGPNLPAADLLAFCTRVKPALILLSLTEEMSEATAKRLAEDLDTLGAQWSVGIGGRGSHAIQPLLRDTKIELLDDPLLLRNRLSALVAAKTMASRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1R6</accession>
    <name>A0A1W1I1R6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized zinc protease YmxG</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ymxG</name>
        <name evidence="5" type="ORF">NSJP_0760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0760"/>
    <dbReference type="EnsemblBacteria" id="SLM46932">
        <property type="protein sequence ID" value="SLM46932"/>
        <property type="gene ID" value="NSJP_0760"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0760"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="154"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="407" mass="45976" checksum="D7E1D50AD4C3771D" modified="2017-06-07" version="1">MVTERIPTLKSVTVGIWVNTGSRDEQPSQAGYSHFIEHMFFKGTRSRSAAEISREIDGLGGEMNAFTTRETTTFYVKVLDQQLERALELLSDLFYRSQFNAKELEKEKQVVLEEIRMVQDDPEDYVQELHMMQILGHHPLGQSILGQEKTIRGLKRENILAYIKARYDPARIVIAIAGNFEQHSLEKLVSRYFRFARTGESSSSSSPVRRPPEVKGGLLVRQKALEQVHLCLGLRGVAAGHQDRYAAYALNSILGGSVSSRLFQEVREKRGLAYSIYSFLSGYSDGGTITVYAGTRAKEAARVVDLICREIRRLRNTGVEKRELERAKNQMKGSLMLSLESSHSRMSKLAKDELIHGSRVSLEEILRQIDRIKPEQIDRVGRELFGLDRLSITGLGPISQRALQSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1T1</accession>
    <name>A0A1W1I1T1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46783">
        <property type="protein sequence ID" value="SLM46783"/>
        <property type="gene ID" value="NSJP_0611"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0611"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="85" mass="9490" checksum="5D727F12E5624CF9" modified="2017-06-07" version="1">MSRLIGVCLGGHMSDNVLHCRAWCDTTPHLFTAFNTVFTTPHSLANSTCYHLLEYVTLDVSTLYRSAYGGYHEDGPHRDSNPSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1U0</accession>
    <name>A0A1W1I1U0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0782"/>
    <dbReference type="EnsemblBacteria" id="SLM46954">
        <property type="protein sequence ID" value="SLM46954"/>
        <property type="gene ID" value="NSJP_0782"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0782"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="369" mass="39794" checksum="339B5AB3F2958DEF" modified="2017-06-07" version="1">MSKESIETLVAELVHEEDWRRMRATAACLAGGPKAVQALIDAMHSGPPVLKQEAAAMLARIKDPHAGVALVGLLEDGEAAVRKSGATALEQMAGVLDTETAAALVALLPKTEEGETKRLVTHLVGAIPTAVVPLCQMMKHPDPDAQVTAALMLDQLLDPRSVDAFIDAMGQPAVRDIAVGTLRKLGAIRERIDGTFDALRDVEGASEREEARMATVVDLLGIGRPAVEILIEYLEDEDWLVREAAADLLGKIADVRAVEPLMRRLQHDKDTGVKELAIKALGLIGDARPTALYLEAIPIRPLRVYAMEALAKIKDVEVLRPHKELFDRLRTDRDGLVAYNAGLIADKLEALTAEPAGDQIGDQEGQSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I210</accession>
    <name>A0A1W1I210_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47011">
        <property type="protein sequence ID" value="SLM47011"/>
        <property type="gene ID" value="NSJP_0839"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0839"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="99" mass="11290" checksum="DE5F1D5E9076EFE0" modified="2017-06-07" version="1">MREAESSRIAAIQGYLVRKFPGWTVDHHQETTDTKLEVFTIIGGPTSQTFKVKFAGDFLEECDPPQIEQILEQWQVGDFLKLSGFWPILVTRAGLHSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I238</accession>
    <name>A0A1W1I238_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47052">
        <property type="protein sequence ID" value="SLM47052"/>
        <property type="gene ID" value="NSJP_0880"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0880"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="567" mass="62087" checksum="3C92B099BF23284C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I275</accession>
    <name>A0A1W1I275_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0922"/>
    <dbReference type="EnsemblBacteria" id="SLM47094">
        <property type="protein sequence ID" value="SLM47094"/>
        <property type="gene ID" value="NSJP_0922"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0922"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="330" mass="35818" checksum="5E8DDC6DC672CC6A" modified="2017-06-07" version="1">MAKPPDRKVPLRTARALIPPINVSDLKTYPLKKRHSKVRVSDFAEPWRRGGSFARFYRSLPDILGAKTLRAVAASIAAAHRKRRPVIVGIGAHVVKVGLTPIFVDLMNRGIVSAIAMNGAGIIHDFELALMGHTSEEVDAEIDQGRFGMAEETGRMINDAIIRGANEERGLGEAVGRYINDSPGLFRNHRTSILAAGVRLGIPVTVHVAIGTDIIHMHPSADGAAIGATSLFDFRRLTAVVSRMEGGVYLNMGSAVVLPEVFLKTVSLARNLGHPLTQITTVNMDFLSHYRPLTNVVRRPTQKGGRGYALIGHHEIMVPLLAAAIYEELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2C9</accession>
    <name>A0A1W1I2C9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0801"/>
    <dbReference type="EnsemblBacteria" id="SLM46973">
        <property type="protein sequence ID" value="SLM46973"/>
        <property type="gene ID" value="NSJP_0801"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0801"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010724403" evidence="1">
        <location>
            <begin position="28"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="2">
        <location>
            <begin position="120"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="220" mass="22903" checksum="7AEC42A5056169F1" modified="2017-06-07" version="1">MSSGFRRPNPFLMACLLALLPFSPAPAFDNLHVASVPALAVLSDGRTGAVHYIALQISSDPGADGPVIQFSEINLGGGSLVGDDWKAGVRQAVLTALRHLGMDGRDWVVTVKNRSHNAMTDGMSASGAVAVGIMAAWRGDAIRPGVAMTGQIAPNGDILGVGSVPQKVEAAAREQFNTVLVPRGQSNMGDGNFGSQARRVAVIEVGTLDEAYHAMAGPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2D5</accession>
    <name>A0A1W1I2D5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1008"/>
    <dbReference type="EnsemblBacteria" id="SLM47180">
        <property type="protein sequence ID" value="SLM47180"/>
        <property type="gene ID" value="NSJP_1008"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1008"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="155" mass="17011" checksum="80A92A253F3BCAEB" modified="2017-06-07" version="1">MRGPGPVDSFGTILSGLAKRLGLESRLLELRVQREWGRIVGEPIASHTWPDQIRFKKLYLIVRSSVWMQQLTFLKPALLAKLQQVDGSITDLSLRVGEIPSSRSAVDATSSTNPLPTTEAALIEATAHAAAVQDEDLRQRLTRVMADALSRAGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2D9</accession>
    <name>A0A1W1I2D9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dnaN</name>
        <name evidence="13" type="ORF">NSJP_1004</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1004"/>
    <dbReference type="EnsemblBacteria" id="SLM47176">
        <property type="protein sequence ID" value="SLM47176"/>
        <property type="gene ID" value="NSJP_1004"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1004"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="133"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="255"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM47176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="375" mass="41111" checksum="CFBA480AF3359CF4" modified="2017-06-07" version="1">MKVRIGRDELLTGLQRVQGVVEKRNTMPILSNILLEAKQEGAEIIATDLEIGMRGLYKATVQKTGGITLSARKLYEIIKELPSGDIEITSGENNWTSIQAGKSQFKIVGLPSADYPALPTIEREGLIPLAGAGLLELIRKTLFAAGDNDARYILNGLLVMLISADRKTTLRLVGTDGHRLAVAEQELGKPEGKSVPQEIKAIIPKKAAHEMRRLLEEGGDGEPLIGFTKNLMIFRKSGLLLTSRLMEGNYPNYQQVIPKESNRRISVNRLEFESALRRVSVLSRDKANAVKLSFTAGRLSLFSSSPDYGEATEDLSAQYEGEALNTGFNARYLLDVLGVMDGETLSLQMDNPLSPCLIQEAESPGFKCVVMPIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2K0</accession>
    <name>A0A1W1I2K0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">adh</name>
        <name evidence="4" type="ORF">NSJP_1064</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1064"/>
    <dbReference type="EnsemblBacteria" id="SLM47236">
        <property type="protein sequence ID" value="SLM47236"/>
        <property type="gene ID" value="NSJP_1064"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1064"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="16"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="355" mass="37241" checksum="4C649486368922B2" modified="2017-06-07" version="1">MATMRANVFHSKGKFGVAETPMPKAGYGQAVIRVTLTTICGTDLHIVRGEYQIKPGLVLGHEPVGVIAELGAGIAGYDIGDRVLVGAITPCGQCRACLSGHQAQCGQSAAGYQAIGGWRFGNTLDGAQAEYLLVPHAQANLAKIPAELTDEQVVLLSDIASTGFSGAESGGVRLGDAVAVFAQGPIGLCATIGARLMGAALIIAVDTDPLRLRMAVRMGADIVLDPKQTDVVADIKQLSGGGVDVAIEALGLQETFENALRCLRPGGTLSSLGVYSGKLHVPYDAFAAGIGDYRIVTTLCPGGKERMTRLMELVRHRRIDLAPLLTHRFSLENIAEAYDLFGRRGEGVLKVAVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Q7</accession>
    <name>A0A1W1I2Q7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yqjG</name>
        <name evidence="3" type="ORF">NSJP_1083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1083"/>
    <dbReference type="EnsemblBacteria" id="SLM47255">
        <property type="protein sequence ID" value="SLM47255"/>
        <property type="gene ID" value="NSJP_1083"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1083"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="PTHR32419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="50"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="314" mass="36678" checksum="FA3330467B05FBD0" modified="2017-06-07" version="1">MAGRAQFPDEQSDQGEFKRQDDAFRQWITADGSSGYPAASGRYHLYVSWACPWAHRTIIVRRLKKLESVIGMTVVDPIRDERGWAFREGPGHSLDSLNGFHFLSDAYRATDSHYRGRVTVPVLWDTVAKRIVSNSDDDLMRMLNGAFDGFAESRIDLYPQRLQRDIDDLNEFIYENVNDGVYRAGFSTSQRVYEQAVRRLFDALDQLDARLKTRRYLFGETFVETDWRLFVTLIRFDAVYHGHFKCNIRRIIDYPNLFAYLKDLYQTEGIADTVNFDHIKRHYYVTHDDINPTRIVPLGPIQDLSSPHHRERLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2X3</accession>
    <name>A0A1W1I2X3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Glycosyl transferase, group 1</fullName>
            <ecNumber evidence="3">2.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47344">
        <property type="protein sequence ID" value="SLM47344"/>
        <property type="gene ID" value="NSJP_1172"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1172"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="18"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="174"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="372" mass="41363" checksum="161E39C59C11C2DE" modified="2017-06-07" version="1">MKIAQISPLWESVPPKLYGGTERIVSYLTEELVRQGHEVTLFASGDSKTKAKLQSFCPHALRLHTGLVNRDAPLVLQLERALGAASAEFDVVHSHLDFLGFPMSRRAHVPVVTTMHGRLDLPELGPIFQEYAEMPVVSISNAQRTPLPGANWADTVYHGIPADLYRPHDRPGSYLAFLGRISPEKCPDQAIELAKRVGMPLRIAAKVDPADQDYFKQKIERLLNHPLIEYVGEINDAEKDDFLGHAAALVCPYDWPEPFGLVLIEAMACGTPVLAYRRGSIPEVIDHEVTGFVCDNLDEMVAAVPRIASIDRRRCRQVFESRFTVERMVHNYVALYERMIAQPVRTKPHAHVRAGEHGLVGAGTTLTKTDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Z9</accession>
    <name>A0A1W1I2Z9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA ligase (ATP)</fullName>
            <ecNumber evidence="2">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">NHEJ DNA polymerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ligD</name>
        <name evidence="16" type="ORF">NSJP_1173</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1173"/>
    <dbReference type="EnsemblBacteria" id="SLM47345">
        <property type="protein sequence ID" value="SLM47345"/>
        <property type="gene ID" value="NSJP_1173"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1173"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04862">
        <property type="entry name" value="PaeLigD_Pol_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014146">
        <property type="entry name" value="LigD_ligase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014143">
        <property type="entry name" value="NHEJ_ligase_prk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033651">
        <property type="entry name" value="PaeLigD_Pol-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02777">
        <property type="entry name" value="LigD_PE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02779">
        <property type="entry name" value="NHEJ_ligase_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02776">
        <property type="entry name" value="NHEJ_ligase_prk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="15">
        <location>
            <begin position="316"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="529"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SLM47345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="864" mass="97644" checksum="6CBE8420020D32EE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3A5</accession>
    <name>A0A1W1I3A5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction response regulator, receiver domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1314"/>
    <dbReference type="EnsemblBacteria" id="SLM47486">
        <property type="protein sequence ID" value="SLM47486"/>
        <property type="gene ID" value="NSJP_1314"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1314"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="15"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="135" mass="14778" checksum="31C66243C9EE8A9B" modified="2017-06-07" version="1">MEEYDLERTGNAMPSILIVDDEDQVRQLIRTTFEEAGYRVAEASNGRDALEQYRLQPADVVITDILMPDQDGLECITVLRREAPGAKIIAITGGSDMIGVLGFLDVAKMLGAYSTLQKPFEMKALLEAAESALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3J3</accession>
    <name>A0A1W1I3J3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribose-5-phosphate isomerase A</fullName>
            <ecNumber evidence="2">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Phosphoriboisomerase A</fullName>
            <shortName evidence="2">PRI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">rpiA</name>
        <name evidence="3" type="ORF">NSJP_1398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1398"/>
    <dbReference type="EnsemblBacteria" id="SLM47570">
        <property type="protein sequence ID" value="SLM47570"/>
        <property type="gene ID" value="NSJP_1398"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1398"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00170">
        <property type="entry name" value="Rib_5P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020672">
        <property type="entry name" value="Ribose5P_isomerase_typA_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="31"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="86"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="99"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="232" mass="24915" checksum="40C7F150C7D139E1" modified="2017-06-07" version="1">MSDTDLSAYKRSAALTALDYVKDGMVLGLGTGSTAKEFIMALGTKVAAGMKLRGVSTSRETATLADRSGIVLLDDNDHWPIDVAVDGADQVDPSFNLIKGGGGALLKEKIVAVSAKQFIVLIDYTKRVPFLGKTFPLPIEVISFGWRNTARAIEALTRSRVVLREQAGAPFRTESGNLIVDTHMARIDNPRELDAALHHIPGIVETGLFIDCADVLIVGTPQGVETYHATRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3N1</accession>
    <name>A0A1W1I3N1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YkuD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_1403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1403"/>
    <dbReference type="EnsemblBacteria" id="SLM47575">
        <property type="protein sequence ID" value="SLM47575"/>
        <property type="gene ID" value="NSJP_1403"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1403"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="209"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="368" mass="41412" checksum="F7E625B1B6A32D7D" modified="2017-06-07" version="1">MAALVLSCLLTGCVKTVPEEAVQAVASVDRDLVRLRASEIAPDEYARFTQQWMILKARVEAEDDTIQWPWEPNDLESALRGLHEEGLQAVSRLAEQRESLRHAAEQQLLRAEDRARALARKVGAIDSRLVLGRNPVETELLLKQARSFYQQGEYAHSLAASDQAAQRLATQASLLNSELGHYANRERIARWQQMVKETVDWSRTHRTSAIVVSKADRRLILYRNGQPVLSYSVRLGFNGIREKRYQGDGATPEGRYRVTTKRGQGHTQFFRALVLDYPNAEDRRRFLLDRKTGHIPDSRGIGGQIEIHGTQNELMAASLGCVMLENPQMAWLFNRVDKGTPVTIVGALDEQNSVALVLADLRSHANEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3R2</accession>
    <name>A0A1W1I3R2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">hisC</name>
        <name evidence="5" type="ORF">NSJP_1474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1474"/>
    <dbReference type="EnsemblBacteria" id="SLM47646">
        <property type="protein sequence ID" value="SLM47646"/>
        <property type="gene ID" value="NSJP_1474"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1474"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="32"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="360" mass="39469" checksum="5121E9C6AFD0F238" modified="2017-06-07" version="1">MTIHVHPDILSLSPYVPGKPIEELQREFGLERVIKLASNENPLGPSPKALAVLNEGMATLHRYPDGGAFRLRQALADRWKVTPDQVILGNGSDELLGLLARTFLSPGDEAVMADHTFVIYKMEVVAAHGKAVTVPLVQWRHDVAAMAEAMTPRTKLLFLCNPNNPTGTMVSREEVARLLSQVPEHVVVVFDEAYFEYVRSADFPDSMTYVRQGRNAIVLRTFSKIYGLAGLRIGYGITTPEITNLLNRVRPPFNANSLAQLGALAALGDDEHVATSRAVNESGMDQLKSGLAALGCMPVPSEANFLYFDAGCDGRRIFEALLRQGVIVRHIEGRMVRVTVGQAEENQIFLTALARVLKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3S0</accession>
    <name>A0A1W1I3S0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47615">
        <property type="protein sequence ID" value="SLM47615"/>
        <property type="gene ID" value="NSJP_1443"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1443"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="97" mass="11117" checksum="2D1AFEBBFDFBD1E4" modified="2017-06-07" version="1">MNVHFLLTKTTGTVRKIMGLSLFLSSVVSSFLSRTQWVLGWNHGTDDPPRAHVEDRFANDEWLCHYYNIPTTSMSLYQSNPESYETGGGLFNTYWGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3U9</accession>
    <name>A0A1W1I3U9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47686">
        <property type="protein sequence ID" value="SLM47686"/>
        <property type="gene ID" value="NSJP_1514"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1514"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="2">
        <location>
            <begin position="16"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="116" mass="13043" checksum="C187BAD35F081A41" modified="2017-06-07" version="1">MALRAQSVRESQSIDKRTHPRFTAQFRSTFSGGQREGQGKTLDLSDGGCRIESEHVVVLGATFECRIHVPGLNWPLRIDEAQVRWVKGNAFGVQFTSIQPTERVKLKQVIAHLTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4D8</accession>
    <name>A0A1W1I4D8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Transcriptional regulator acrR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1706"/>
    <dbReference type="EnsemblBacteria" id="SLM47878">
        <property type="protein sequence ID" value="SLM47878"/>
        <property type="gene ID" value="NSJP_1706"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1706"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039536">
        <property type="entry name" value="TetR_C_Proteobacteria"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14246">
        <property type="entry name" value="TetR_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="214" mass="24056" checksum="81E9F78A09634C35" modified="2017-06-07" version="1">MQTMDKRRRPSSQERQAGLIAAAASLFAAKGFNGTTTREIARAAGVSEALVFKHFPTKRALYAAILAEKVSVDGLLGAVEESAKKRDDHRVFMLIAGFRIRPGVDPTLLRLLLFSALEGHELSDIFFAKHHKVFYDHLASYIQLRIKEGAFRDVDPLLAARAFIGIVVHHRLLHEIFGVPMHRTHDETVATYVELFLNGLIRQDGGHRRRRRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4W2</accession>
    <name>A0A1W1I4W2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclopropane fatty acyl phospholipid synthase (Unsaturated-phospholipid methyltransferase)</fullName>
            <ecNumber evidence="2">2.1.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cfa</name>
        <name evidence="2" type="ORF">NSJP_1691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.79" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1691"/>
    <dbReference type="EnsemblBacteria" id="SLM47863">
        <property type="protein sequence ID" value="SLM47863"/>
        <property type="gene ID" value="NSJP_1691"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1691"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008825">
        <property type="term" value="F:cyclopropane-fatty-acyl-phospholipid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="381" mass="43923" checksum="695B81CE075E4CFD" modified="2017-06-07" version="1">MAGAVGHSEQRIMSQKSTIESLLEKAGIQVDGPEPGDIRVHDDRFYARVLAEGSLGLGESYMDGWWDSRRLDDFFAKFHDVPLDHAVVDKYLIMNALKARLFNMQNMRLSKRVAQQHYDLDNAFYEKMLGPHMQYTCAYWKRAQDLETAQKHKLDLICRKLHLQKGERVLELGCGWGGFARYAATHYGCSVTAYNISEQQVSYARKWCEDLPVEVIQGDYRSASGEFDKVAAIGLCEHVGYKNYRTLMETVHRTLKRRGLFLLHTIGNNASVSTADPWFDKYIFPGGMLPSVAQLSAAMDGLLVLEDWHNFGPDYDRTLVAWQENVDRHWDELKAKFDERFRRMWRYYLLSLAGAFRARRIHLWQVVLSKHGALGGYEPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I503</accession>
    <name>A0A1W1I503_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48065">
        <property type="protein sequence ID" value="SLM48065"/>
        <property type="gene ID" value="NSJP_1893"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1893"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="58" mass="6790" checksum="D0E8703FDE1B0CAE" modified="2017-06-07" version="1">MRIVDQEILDPAVSTGDHARNRHQRRLLLVDLGTRNLVFRECLKDGTETFFVEYEAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I531</accession>
    <name>A0A1W1I531_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4-hydroxybenzoate octaprenyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ubiA</name>
        <name evidence="6" type="ORF">NSJP_1859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.-" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1859"/>
    <dbReference type="EnsemblBacteria" id="SLM48031">
        <property type="protein sequence ID" value="SLM48031"/>
        <property type="gene ID" value="NSJP_1859"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1859"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="310" mass="33297" checksum="8A619E5A32610F94" modified="2017-06-07" version="1">MRPQADPMAPVTDSPPQTLAENRGARFSWSAAARLIRLHSQTGTWLLLLPTLWSLVLAARGVPALGLIVTFSAGSFLMRSAGVVLNDLADRSVDREVARTRTRPLASGELSFYHACGLAALLLGAALALVLTLNQLTLLLSPIAMVLAGLYPFAKRVVHVPQAILGIAFGWGTIMAWAASRGTIESPAWLLFGATICWAVGYDTIYALQDREDDRRIGVKSSALFFDRWTWLAVAAAFGGMLTFLVLAGLETGIGWIYYAALAIAAVLFAKQTVELAGSVSAARAFTLFHRHVWIGSGILAGMLAGFLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I534</accession>
    <name>A0A1W1I534_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48095">
        <property type="protein sequence ID" value="SLM48095"/>
        <property type="gene ID" value="NSJP_1923"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1923"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="72" mass="8519" checksum="03794281A77CC55F" modified="2017-06-07" version="1">MPIACIFEHRHSTERFENARADNTCYFLRRVLITAQSFISSIGSTFLNYTYYFFEFFELVASILLDNLTHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I562</accession>
    <name>A0A1W1I562_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48136">
        <property type="protein sequence ID" value="SLM48136"/>
        <property type="gene ID" value="NSJP_1964"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1964"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="101" mass="11056" checksum="59B2118E6F8D8721" modified="2017-06-07" version="1">MSFMAMNHPGRAKVLVIIAIWFFTGGLSFADNFDLTDDLRNSLPDLPQALEPDLDEVRETAEPELASSGHFSPPLFDPAARGTRLQPFSGTSLHEARPAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5A2</accession>
    <name>A0A1W1I5A2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48182">
        <property type="protein sequence ID" value="SLM48182"/>
        <property type="gene ID" value="NSJP_2010"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2010"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="153" mass="17208" checksum="08FCD86F16CB2686" modified="2017-06-07" version="1">MRAVEKTYKPDSVPTRICSQSAEIISLGFGLPRTSSDLPEDLSRASWSPALRKEPMVSSYLALHRTTLTLPVMSPPPRWALTPPFHPYLCRNDERSHRVGHRRSVLCGAGVGLLRLGVTQRPAREVRTFLSSRSAMSDPPVFPLAQSQYRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5B6</accession>
    <name>A0A1W1I5B6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48079">
        <property type="protein sequence ID" value="SLM48079"/>
        <property type="gene ID" value="NSJP_1907"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1907"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="437" mass="49040" checksum="F97B79CC8D7875C2" modified="2017-06-07" version="1">MPGVSRTVATLDYQYRGEESHGTATCGCSDGNLQHGSQYPTLARQGVHQMIESIAQIYAQVQPDSWRQRQDFSAEIREAQAMLFDEASKGRKDAIAKILGKWLERYQPCLFGRVAARLDLIEYCVLLEEDLYKSDEEVLSLIQDARTRWTRDGFYGRKNAFIIFAVSPRLSSALPDATMMRLARRLAFLYLRQEVEPDQIYFDELYLEIPGNSKTTWKWPTGINYFAAHGDGRWWHDHRIPGGIAFSINSIGHMVKSGRLAKGMNDLLELVDSAEEGWNPSLVDSLDKALDLSMRTINGASDTVSGRATFLLPITEEERQRLPTCPIQLPKLLAGNNHCEYAGFYHTDYTIPSEYFLPDVERPIGTTKHILDFTYLFRGDVNNPDYDQLGSGTRIRGGIDMATQASSVRANKGTPIAVDVADVPRLVAALGNEGQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5F1</accession>
    <name>A0A1W1I5F1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48232">
        <property type="protein sequence ID" value="SLM48232"/>
        <property type="gene ID" value="NSJP_2060"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2060"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="60" mass="6465" checksum="E3A8CB9A41008A75" modified="2017-06-07" version="1">MLSEDVRRAVSRSGVTDRIAPNESLAGGTQGPGEERYGRMWEKLPVSAGRTTGKPVTFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5F5</accession>
    <name>A0A1W1I5F5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48161">
        <property type="protein sequence ID" value="SLM48161"/>
        <property type="gene ID" value="NSJP_1989"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1989"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="74" mass="8349" checksum="0907E639FAC9EFFA" modified="2017-06-07" version="1">MPYRMEKNNGALSHMEQTPRFLYMAPRAGLEPATSRLQGLPIFRKGLDYLFTHLGFQGRVSGAREAILGRLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5P9</accession>
    <name>A0A1W1I5P9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein L11 methyltransferase</fullName>
            <shortName evidence="2">L11 Mtase</shortName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">prmA</name>
        <name evidence="3" type="ORF">NSJP_2165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Methylates ribosomal protein L11.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2165"/>
    <dbReference type="EnsemblBacteria" id="SLM48337">
        <property type="protein sequence ID" value="SLM48337"/>
        <property type="gene ID" value="NSJP_2165"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2165"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00735">
        <property type="entry name" value="Methyltr_PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004498">
        <property type="entry name" value="Ribosomal_PrmA_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="298" mass="32924" checksum="73D34B1625D91F73" modified="2017-06-07" version="1">MGPYWKPDMPSTPSDWIDVRILSCPAASEFLGLLDDPDVGGVWEDGESLHLYWPTLRWSSERLDRVRLTLRRLRGEEQLLPEIRIDSLPHQDWNRQWAESVKPLRIGRRIVIRPSWEAAEVQADHVEIVLDPKQAFGTGHHATTRMLLEWLETLALDGATVLDVGTGSGILAMVALRLGAVRAVGFDDDPVAVECAQDYARDNRFGEELTLGCGTLARGERFDLVLANLDAATLTSLTDELAVATGRRLLVSGLLVDQRGEIAEGFARAGLYQGGVRELDGWTAVEFLRADACDGPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Q3</accession>
    <name>A0A1W1I5Q3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATP-dependent DNA helicase Lhr</fullName>
            <ecNumber evidence="4">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2152</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2152"/>
    <dbReference type="EnsemblBacteria" id="SLM48324">
        <property type="protein sequence ID" value="SLM48324"/>
        <property type="gene ID" value="NSJP_2152"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2152"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="29"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="255"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1263"/>
            <end position="1306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1446" mass="159147" checksum="7E5C73B687562DAE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5S8</accession>
    <name>A0A1W1I5S8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48362">
        <property type="protein sequence ID" value="SLM48362"/>
        <property type="gene ID" value="NSJP_2190"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2190"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="157" mass="17834" checksum="86DD239CF10F5C23" modified="2017-06-07" version="1">MAQKFGNGRWVREGFLDNRVEGTVIGRIVLAAVGPVDLFLKGNFKADIAGEIIEFRNRRFEEDDTAAQVIGDMENPQIGTVNLISFDPHPNLVPHPYVEWFSGRSNHFRFELEPDDAWVVAEERRATIDGQSRAIREALADRVVVDRPRSGEESEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5U2</accession>
    <name>A0A1W1I5U2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48239">
        <property type="protein sequence ID" value="SLM48239"/>
        <property type="gene ID" value="NSJP_2067"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2067"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="88" mass="9560" checksum="A2AC76006B623E54" modified="2017-06-07" version="1">MPYRVFMLLQLISVAGALMVLAAYGLNQSGVWRELHSGYLTLNIVGSLLLGIVAIADGRAGFILLEFAWAALGILGVIRAFRARQHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5U5</accession>
    <name>A0A1W1I5U5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Biotin carboxylase</fullName>
            <ecNumber evidence="5">6.3.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetyl-coenzyme A carboxylase biotin carboxylase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cfiB</name>
        <name evidence="8" type="ORF">NSJP_2183</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2183"/>
    <dbReference type="EnsemblBacteria" id="SLM48355">
        <property type="protein sequence ID" value="SLM48355"/>
        <property type="gene ID" value="NSJP_2183"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2183"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004549">
        <property type="entry name" value="Acetyl_CoA_COase_biotin_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00514">
        <property type="entry name" value="accC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="7">
        <location>
            <begin position="3"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="121"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="474" mass="52209" checksum="4F9F1C310BC48A05" modified="2017-06-07" version="1">MKMFRKILVANRGEIAMRIIRACRELNIATAAIYSEADSTGIYVKKANEAYLVGPGPVKGFLDSRQIVELAQRIGADAIHPGYGFLSENAQFAELCDASGITFIGPSPLAITTMGSKVKARELAHKIGVPIVPGTEGGITDVKEGLAFAKQTGYPVIIKANAGGGGRGLRVVRSDAELRENMEVAAREALASFGDGSVFIEKYIERPHHIEFQILADRHGNIIHLGERDCSIQRRHQKLIEIAPSLVLTPKLRTEMGKAATAIARAVNYDNAGTVEFLLDQDGRFYFIEMNPRLQVEHTVTEQITAIDIVRNQIAIAAGKPLDIQQKDVILQGHAIQCRINAEDPKNNFMPCTGIVTDYLSPGGIGVRIDGAVYKDYTVPPYYDALLAKLTVRGRTWEETVSRMRRSLEEYVLRGVKTTIPFMKAIMQDQDFLAGRFDTSYLDTHPDLYTYDEIEQPEDLVLALAAAIAAYEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5U9</accession>
    <name>A0A1W1I5U9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-54 dependent transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2215"/>
    <dbReference type="EnsemblBacteria" id="SLM48387">
        <property type="protein sequence ID" value="SLM48387"/>
        <property type="gene ID" value="NSJP_2215"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2215"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="21"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="2">
        <location>
            <begin position="167"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="489" mass="53961" checksum="B55BEF35DD9A678E" modified="2017-06-07" version="1">MSHGGVLDAKTPGKRSKAPFTILIVEDSPTDIELMLHALEDADLKPLGGDFEMEVRANAEGALQLLAERSVDLVLTDMMLPGLSGLDLVGRIQALDPNLPVLVVTRMNTVSQAVDAMRRGAFDYIVKPVNAADLEMRLHRAIRISEILRRHAIYEHHDRQVYESNSLVGGSRAFEQIISRIREATQSRSTVLITGETGTGKGLIARAIHQQSLQPDHPFQIIDCTTLPEGMMESELFGHVRGAFTGAISDKPGLIELANGGTVFFDEIGELPLPLQSKLLRVLEDNEVRPVGGTRVRTVNIRFIAATNRDLERRVRDGSFRKDLYYRLAVISIAVLPLRERREDIPVIARHLLTKLSREMGKPGCHFDERAMEALVAYDWPGNGRELRNVVERAVLLATNETVRASDIRGLLPGREADSAGIPDIGLTSLPYIEAKERAIDQFTKAYLEAKLVQHGGVITKAAESSGIPRQHFSLLMKRFLGSDAAGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5X1</accession>
    <name>A0A1W1I5X1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative Peptidoglycan O-acetyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_2218</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48390">
        <property type="protein sequence ID" value="SLM48390"/>
        <property type="gene ID" value="NSJP_2218"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2218"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="520" mass="58181" checksum="B0CCD28864E4CF76" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I611</accession>
    <name>A0A1W1I611_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Crossover junction endodeoxyribonuclease RusA (Modular protein)</fullName>
            <ecNumber evidence="1">3.1.22.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.22.4" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2091"/>
    <dbReference type="EnsemblBacteria" id="SLM48263">
        <property type="protein sequence ID" value="SLM48263"/>
        <property type="gene ID" value="NSJP_2091"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2091"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008822">
        <property type="entry name" value="Endonuclease_RusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036614">
        <property type="entry name" value="RusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05866">
        <property type="entry name" value="RusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103084">
        <property type="entry name" value="SSF103084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="164" mass="17597" checksum="EFBA22D534FFE6D1" modified="2017-06-07" version="1">MTATAPSANPRRAEIPAATCPETAGVSLVLPVPPSVNHQYATVRGRRLLSAAGRTYKAQVGNLVLLALSKSSHRATVLARLQSNPLVLSIRFYFTSPLRRDVDGGLKIAQDALCEGLGVNDNRIVETHLYKHVDKLNPRIEVSLTAAPSVDSLHPPVPTVADYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I627</accession>
    <name>A0A1W1I627_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48478">
        <property type="protein sequence ID" value="SLM48478"/>
        <property type="gene ID" value="NSJP_2306"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2306"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="103" mass="11058" checksum="7430604BA813E4B2" modified="2017-06-07" version="1">MLDHSMPSQNGRVSGEVSSVVVAMATAPLIVEGGVAFQVPDVVGENLVPPIRIERTTRGLGNRCSIQLSYGGMVEYHIVARSQGQALFRRSGITAKLSRHFPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I669</accession>
    <name>A0A1W1I669_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2151"/>
    <dbReference type="EnsemblBacteria" id="SLM48323">
        <property type="protein sequence ID" value="SLM48323"/>
        <property type="gene ID" value="NSJP_2151"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2151"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="563" mass="56529" checksum="576CE088D6EF1E6D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6C4</accession>
    <name>A0A1W1I6C4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2257"/>
    <dbReference type="EnsemblBacteria" id="SLM48429">
        <property type="protein sequence ID" value="SLM48429"/>
        <property type="gene ID" value="NSJP_2257"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2257"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="148" mass="16694" checksum="E9E33C63AF7040C1" modified="2017-06-07" version="1">MSLRDRLSEDLKQAMKARDQLRMDVIRMIKAAVLNKEVEVKKDLDDAEMSRIMTTMIKQRKESVEQYEKGNRSELAAKERQEISIIESYLPKALTQEELAEVVSNVIRDTGAASLKDMGAVMKAVMSRLGGQPVDGKQVSDLVRAKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6H1</accession>
    <name>A0A1W1I6H1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperonin GroEL</fullName>
            <ecNumber evidence="6">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Chaperonin-60</fullName>
            <shortName evidence="6">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">groEL</name>
        <name evidence="6" type="synonym">groL</name>
        <name evidence="9" type="ORF">NSJP_2435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2435"/>
    <dbReference type="EnsemblBacteria" id="SLM48607">
        <property type="protein sequence ID" value="SLM48607"/>
        <property type="gene ID" value="NSJP_2435"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2435"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="479"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="546" mass="58286" checksum="2AA969EF7BD61609" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6H6</accession>
    <name>A0A1W1I6H6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48443">
        <property type="protein sequence ID" value="SLM48443"/>
        <property type="gene ID" value="NSJP_2271"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2271"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="126" mass="13922" checksum="CB8E4076D08F292A" modified="2017-06-07" version="1">MTAADSCSACRASGIPLMKLSLGKDFFGRTYDRLSPSSDQSPMWFCEGCSMQKNLQRDFRDIRAEHDKLAAGQHSELSNQEAFQRATLRLREIVAILGGSSGQSTLLNAADVKSLIDRFQTTTMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I708</accession>
    <name>A0A1W1I708_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LptD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2651"/>
    <dbReference type="EnsemblBacteria" id="SLM48818">
        <property type="protein sequence ID" value="SLM48818"/>
        <property type="gene ID" value="NSJP_2651"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2651"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015920">
        <property type="term" value="P:lipopolysaccharide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010033">
        <property type="term" value="P:response to organic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01411">
        <property type="entry name" value="LPS_assembly_LptD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020889">
        <property type="entry name" value="LipoPS_assembly_LptD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007543">
        <property type="entry name" value="LptD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04453">
        <property type="entry name" value="LptD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012935627" description="LptD domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="LptD" evidence="2">
        <location>
            <begin position="300"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="816" mass="90718" checksum="C79C2C5D14612B27" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I714</accession>
    <name>A0A1W1I714_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48828">
        <property type="protein sequence ID" value="SLM48828"/>
        <property type="gene ID" value="NSJP_2661"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2661"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="36"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="303" mass="33882" checksum="D0A0FD29270F2A95" modified="2017-06-07" version="1">MGMRHVVHRTAWALTIGAILVHSSGRHAAAEEHSPEAAIRAMVRANAEKDMAALSRLMAHDSDIISYTIGGRKYVGWPDIERDMLEEFGSAAELDLPIRELKVWTKGDLAWYTMELDYIRTVVQDQKSQRALLPLRETGVLERRDGQWVLLSWHESFRNSGGAVQLADETSHDASVRPTVVSQNGETDLSGEWTILEVEDNKTYKATLDKAGNGPYSQQGGRFITTKLEDRAWHGTWHQTGNDREGGFEVLLSEDGAQAKGVWWYTRVGDKKNIPPRQWGGTYIWKRIAPAPPIGEPAPGVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I752</accession>
    <name>A0A1W1I752_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2532"/>
    <dbReference type="EnsemblBacteria" id="SLM48699">
        <property type="protein sequence ID" value="SLM48699"/>
        <property type="gene ID" value="NSJP_2532"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2532"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="235" mass="26819" checksum="9A4EBB2B2C461DE6" modified="2017-06-07" version="1">MNGIIKIDEFLRSYPRMNAAPIYDGSMCLEGIIDFSADSEECGLISDSFQLRMVVPETFPNDLPIVYELGGRIPRDRSYHINQYDNSLCLGSRLRLLLTISKRPTLMGFTQNCLIPYLYAVSRKLSLGGCFAFGELPHGMKGEVEDYRLLFCLQTTDQVWKTIDCLGMKKRRANKHPCPCGCGRTLGRCRFNRRIRKFRSLTGRTWFQNVARELKREPPTQASLVTTAQKVMACI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I770</accession>
    <name>A0A1W1I770_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48857">
        <property type="protein sequence ID" value="SLM48857"/>
        <property type="gene ID" value="NSJP_2690"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2690"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="56" mass="6730" checksum="C311B78B6F538C67" modified="2017-06-07" version="1">MIAGFLFTWARRRFMNIRRILPELTHQNILMYGISCRTQEVSTPSRSFTHYPTRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I771</accession>
    <name>A0A1W1I771_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ECF subfamily RNA polymerase sigma-24 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48872">
        <property type="protein sequence ID" value="SLM48872"/>
        <property type="gene ID" value="NSJP_2705"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2705"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="111"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="165" mass="19282" checksum="AAB22C3E889E7A7D" modified="2017-06-07" version="1">MSQTQLSQVFLEHEEDLFRFLLRRIKCVFTARDMTHDLFLKISAQGETAHIQNQKAYLFRMAANLATDYLRVEQNRAHILAETNELLWGDTDGRDPERISIAREELARSERVLAQLPLLSRKIFHLNRFEGKSYPEIANELNLSPSTVEHHIRTALRQLSKVRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I774</accession>
    <name>A0A1W1I774_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2552"/>
    <dbReference type="EnsemblBacteria" id="SLM48719">
        <property type="protein sequence ID" value="SLM48719"/>
        <property type="gene ID" value="NSJP_2552"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2552"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033425">
        <property type="entry name" value="MASE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17159">
        <property type="entry name" value="MASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="383"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="481" mass="53095" checksum="21CA2DD1EC51DD54" modified="2017-06-07" version="1">MNQPLVLYLVVTVCGGGALLVSTALHTLWPDWRWQYEPLHSTIEAVGGLVAIGMAMVLPHRYGKSTTDKYRALAAGFLGMGILEEFHAMARPGNAFVLFRNMASLAGGIGFLLVWRSRGTVGGSERRWVPWMIAAGTVMIGTWFLMFPQSIPEMVRNGEFTPTAVAPQSVACLLFLLGAVRFLLDYRRSGQSEDALFASLALLFGLAEFVFMYSIPWDNRWWFWHSLRLIACLLALGFIGNSYFQITSDLQTSLAQNIQAKETISQREGQLRQILSERERMAQDLHDSTIQSLFAIGLNLERCQRLVSTAHHEVAAQLGSAAEGLKGVIRDLRGYILGLESPISNGRALEAALASLVNDVNNSSQLHCLLDVKPEAAERLTPEQAAQMLSIAREATSNILRHASAHTINLSLHLHDGGIRLMVEDDGVGFDRATVHGHGHGLKNMEKRARMLGCRFEVQSGPGHGTRIECLLHHRHDEASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I796</accession>
    <name>A0A1W1I796_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Quinol-cytochrome c reductase, iron-sulfur subunit (Rieske iron-sulfur protein)</fullName>
            <ecNumber evidence="9">1.10.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_2511</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.10.2.2" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2511"/>
    <dbReference type="EnsemblBacteria" id="SLM48683">
        <property type="protein sequence ID" value="SLM48683"/>
        <property type="gene ID" value="NSJP_2511"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2511"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="8">
        <location>
            <begin position="60"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="182" mass="19536" checksum="DBB8B393E5049BD8" modified="2017-06-07" version="1">MSASDLHPSDASGLSTPAGTRRRFFQWVTSAAAGLIGLSLAIPLVGYVISPALKRRAQSWVDVAALDELSVGKPKQVDYVATVQDGYLETKTQKAVWAVKQADGQVTVFSPMCTHLGCGYHWNEGEQKFKCPCHGSVFDLSGRVVGGPAPRPLDALPSKTENGRLLVMYKEFKSGATGQVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7D5</accession>
    <name>A0A1W1I7D5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2791"/>
    <dbReference type="EnsemblBacteria" id="SLM48958">
        <property type="protein sequence ID" value="SLM48958"/>
        <property type="gene ID" value="NSJP_2791"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2791"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="135" mass="15013" checksum="EA984C72E8B9B4B7" modified="2017-06-07" version="1">MGELLHVRTTATKEVVDLTDRVQTIVRQAKMKEGLCCLFVSHTTAGLTTGEIGEGTEEDFLQIVEQIIPRIRFRHAHDPSHAWSHMAASLLGPSLAIPVSSGKLALGTWQSVMLVELDGPRERTIHCMLYPERQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7J8</accession>
    <name>A0A1W1I7J8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">General secretion pathway protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">NSJP_2734</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2734"/>
    <dbReference type="EnsemblBacteria" id="SLM48901">
        <property type="protein sequence ID" value="SLM48901"/>
        <property type="gene ID" value="NSJP_2734"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2734"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011850">
        <property type="entry name" value="T2SS_GspF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001992">
        <property type="entry name" value="T2SS_GspF/T4SS_PilC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02120">
        <property type="entry name" value="GspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00874">
        <property type="entry name" value="T2SP_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="18">
        <location>
            <begin position="80"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="18">
        <location>
            <begin position="284"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="SLM48901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="413" mass="45501" checksum="51DBB7A913916312" modified="2017-06-07" version="1">MPVYQYRGFKQDGGSATGIIDAESPKVARLKLRKDGVFPTEMLEQGNAGQSPAAASRPSAGPPAISGRSALGQGDIAMMTRQLATLLVAGLPLVDALGVLLEQTDKKSVKSILADIREEIRGGKSYSVALERYPREFSQIYVHMVRAGEASGALDQILFRLAEFLEKQLALKHKVTNAILYPALMLLVGVGVLFFLMTFVVPKITAVFANLKQTLPWPTVVLMTLSRWCSDYWPVLAGGAVVLIWTVRRIIRTESGRILADRLILKLPLIGDVARMVSISRLSSTLATMLGSGVQLLEAMDVSRRVMNNRVLEHAVEEARQNIREGETIAEPLKRSGEFPSLVTHMIAVGERSGEMEEMLRRIGQIYDGEVDRVITRFTSLLEPVMILVMGILVFFIVVAILLPIFEMGQMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7M2</accession>
    <name>A0A1W1I7M2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMP-30/Gluconolaconase/LRE-like region-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2855"/>
    <dbReference type="EnsemblBacteria" id="SLM49022">
        <property type="protein sequence ID" value="SLM49022"/>
        <property type="gene ID" value="NSJP_2855"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2855"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="SGL" evidence="2">
        <location>
            <begin position="64"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="323" mass="35600" checksum="6EADF70C9514AB6B" modified="2017-06-07" version="1">MTFSIRPNSEGPTGRLNYRAGRLRGITAIICGLVLLVAQGALRAEDTVLAPGATLQKLAGEFEFTEGPTCDAEGSVFFTDQPNDRIMRWSADGGLSTFLQPSGRANGMYFDYKGNLIACADERNALWSIAPDRQVTVLLGEYQGKPLNGPNDVWVRADGALYFTDPFYRRRWWKHDKMPQDGQHVYFLSADRRQLVRVADDLQQPNGLIGTPDGNTLYVADIGAGKIYRYDIAPDGQLGGRKLFAEYGSDGMTLDEEGHLYLTGEGVRVLDRDGRQIEYIDVPGEAWTANVSFCGRNRRTLFITASKGLYGIKLRVGGANGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7T5</accession>
    <name>A0A1W1I7T5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2878"/>
    <dbReference type="EnsemblBacteria" id="SLM49045">
        <property type="protein sequence ID" value="SLM49045"/>
        <property type="gene ID" value="NSJP_2878"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2878"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025411">
        <property type="entry name" value="DUF4136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13590">
        <property type="entry name" value="DUF4136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4136" evidence="1">
        <location>
            <begin position="27"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="182" mass="20389" checksum="FFC688CD4799CE5E" modified="2017-06-07" version="1">MIADHHAMAGSLACLLFGLAACTSIDVRTEHDPAADFSRFKTFAFAERPVAEESGLDNDAAARDRIESALSRELTNRDVHRVRVEQQPDLTVYYAVAVHEKIQKAWRTGYGWGARYGGGQTTYPYEEGTLIVDLVDPVKQELMWRATMNTHLEETSTGRLDQADRAIARAFEQYPPRTEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7W2</accession>
    <name>A0A1W1I7W2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2844"/>
    <dbReference type="EnsemblBacteria" id="SLM49011">
        <property type="protein sequence ID" value="SLM49011"/>
        <property type="gene ID" value="NSJP_2844"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2844"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029465">
        <property type="entry name" value="ATPgrasp_TupA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14305">
        <property type="entry name" value="ATPgrasp_TupA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="312" mass="36495" checksum="72DB27C4402E49E9" modified="2017-06-07" version="1">MKVWEARQRLNQWSHHDLPRWWEACLPDVYVQKSQFRRVFGRSLNLASPATFNEKLHWLSRHYRDPVMTELADKYSVRAFVEKRAGSEYLNELYGVWEDPSVIPFDRLPGAFALKVTSGSGQNILCRDRLALDRDATIRQLAKWMKHSEYWVSREWAYKDIRARVIAESLLLDESGDVPQDYKFFCFDGVPRFIQVDTGRFTDHRRDLFDLDWQKLPVTYTYPCSDAPLLRPRMLDAMLDLAAKLSQGFPFVRVDLYNIGDSIKFGEMTWYPGGGLERFSPSEYDFVFGEAVTLPQRRRPRGFGMFGLGMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I843</accession>
    <name>A0A1W1I843_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49218">
        <property type="protein sequence ID" value="SLM49218"/>
        <property type="gene ID" value="NSJP_3051"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3051"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009409">
        <property type="entry name" value="DUF1059"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06348">
        <property type="entry name" value="DUF1059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="68" mass="7295" checksum="E9DBE08EB15B69B6" modified="2017-06-07" version="1">MASKPYKQLGCLDVDPKGGCAFQVRAETEDEVLRLTGEHAKLCHKLTAIPPEMAAKVKAAIKTVSVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8B3</accession>
    <name>A0A1W1I8B3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49262">
        <property type="protein sequence ID" value="SLM49262"/>
        <property type="gene ID" value="NSJP_3095"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3095"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="69" mass="7679" checksum="AA0BAD07F18EF0AD" modified="2017-06-07" version="1">MSGSTGRKTVSVMRGLMMLCDTCHSQVLLEKLVDHKNFVMDHEALFDTICMGCTDINRPLIDDMLGSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8B4</accession>
    <name>A0A1W1I8B4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative [lipopolysaccharide]-lipid A 3-O-deacylase outer membrane protein, PagL family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49161">
        <property type="protein sequence ID" value="SLM49161"/>
        <property type="gene ID" value="NSJP_2994"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2994"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018550">
        <property type="entry name" value="Lipid-A_deacylase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09411">
        <property type="entry name" value="PagL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="202" mass="22435" checksum="3BAC49922FE8F039" modified="2017-06-07" version="1">MTRLRPGIIVLLLLLTAGFHPSFARSEEPVSGLRFGMQEVGFSAGYLISVRLTSDHSTKQQGPALMPSWSMILTDPIGKSWYQGQILLGAEIVYVQFQEPVLTHGIGFTPKIKYLFSGYHSLRPYVEFAGGPFYTDLVGYVPEESARLNFILTAGVGLSWFVTPRMALNAGYRFHHISNAGTRYPNVGLNASLPYIGFAFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8C5</accession>
    <name>A0A1W1I8C5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49254">
        <property type="protein sequence ID" value="SLM49254"/>
        <property type="gene ID" value="NSJP_3087"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3087"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="97" mass="11291" checksum="1C7B531E3CA00C10" modified="2017-06-07" version="1">MKQDVVVSSLSKRAAASGKQSGETPLQNALWRLERLEAQMQKLSELVRDHAEDVDRLVRIVAEDRNTIRRQLLRKHHERVRVRKHLRTANAKAVFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8F0</accession>
    <name>A0A1W1I8F0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2007 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49297">
        <property type="protein sequence ID" value="SLM49297"/>
        <property type="gene ID" value="NSJP_3130"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3130"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018551">
        <property type="entry name" value="DUF2007"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09413">
        <property type="entry name" value="DUF2007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2007" evidence="1">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="82" mass="9024" checksum="4229B208EAA72E9D" modified="2017-06-07" version="1">MSLIRIAEPFTPGELVMLQSLLDGSGIEYVLRHANIGSLYPGIPALTSQVFVDERDVARAEHLLSRLRLELREVPQAAPDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8H0</accession>
    <name>A0A1W1I8H0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49304">
        <property type="protein sequence ID" value="SLM49304"/>
        <property type="gene ID" value="NSJP_3137"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3137"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="74" mass="8299" checksum="4E656D4343F1D200" modified="2017-06-07" version="1">MCKLSLRLGETPKYWVLRTRFRPKRSGGDAQKHKKSGTKGALILEFPSNMMMSRDLDNLPAMPAADGPRGRHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8H1</accession>
    <name>A0A1W1I8H1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49221">
        <property type="protein sequence ID" value="SLM49221"/>
        <property type="gene ID" value="NSJP_3054"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3054"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="79" mass="8480" checksum="4F0CE7A6C5F7B363" modified="2017-06-07" version="1">MEAGAKRTMIARIAAGLGTLCGFFGGLASTTKDPWWFTPHGWGIGGILLLLLAIFLLLDGVVSFEKSDPNSIPRRPTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8L6</accession>
    <name>A0A1W1I8L6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3195"/>
    <dbReference type="EnsemblBacteria" id="SLM49362">
        <property type="protein sequence ID" value="SLM49362"/>
        <property type="gene ID" value="NSJP_3195"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3195"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045739">
        <property type="entry name" value="ACT_dom_pair"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19571">
        <property type="entry name" value="ACT_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="72"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="136" mass="14309" checksum="8887173380FA9166" modified="2017-06-07" version="1">MPTTTQLVISGQSKPGVMAQVASVLASAGVNIKAFSAPEVTGTGKLRLLVADLEGARAALRGAKIRFAEETALVLSLENKPGALNEVADLLTQARINIKCGYCTPSREGKRAIVVLTVSNTEKALSVLRDQSLDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8M4</accession>
    <name>A0A1W1I8M4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Anthranilate synthase component 1</fullName>
            <ecNumber evidence="5 11">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">trpE</name>
        <name evidence="14" type="ORF">NSJP_3200</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="5 11"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3200"/>
    <dbReference type="EnsemblBacteria" id="SLM49367">
        <property type="protein sequence ID" value="SLM49367"/>
        <property type="gene ID" value="NSJP_3200"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3200"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="13">
        <location>
            <begin position="33"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="12">
        <location>
            <begin position="229"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM49367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="498" mass="56365" checksum="218ACD42F63A9564" modified="2017-06-07" version="1">MTTAAYSLSLEEFRRYAHEGNLIPLYREILADYETPVSAFAKIDHGPTAYLLESIEGGEKWARYSFLGSGSPIVISEDRGDLMIARGKKKSRIPSKGNPLERLQEYMQEFRPVTVPNLPRFVGGAVGYLGYDMVRTFEDLPSRPKDHLNLPDFAFLMTDTLLIFDNVAQKIKVVANAHLTSTRDRDVTRAYREATERIERMITRLRRPLQRARPHRRRRPITFTSNLSRADFEKMVNRTKEYIRAGDVVQAVLSQRWETNVQAPPLQLYRALRVVNPSPYMYYLRVAGVELVGSSPETLVRCEDGVISVRPIAGTRRRGHTVDEDQQLERRLLADEKERAEHVMLVDLGRNDVGRVSRPGSVSVDSLMHVERYSHVMHIVSNVTGRLDRAKTSYDVLRACFPAGTVSGAPKIRAMEIIDELEPTRRGPYAGAVGYFSFSGNMDMCINIRTVVIKKHQAFIQAGAGIVADSVPEHEYEETCNKAKAMMHAIELAEQGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8N3</accession>
    <name>A0A1W1I8N3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Outer membrane-specific lipoprotein transporter subunit ATP-binding component of ABC superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lolD</name>
        <name evidence="5" type="ORF">NSJP_3210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3210"/>
    <dbReference type="EnsemblBacteria" id="SLM49377">
        <property type="protein sequence ID" value="SLM49377"/>
        <property type="gene ID" value="NSJP_3210"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3210"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="220" mass="24154" checksum="1FC1BA120469F487" modified="2017-06-07" version="1">MITVTDVHKSFLMGERTMTVLQGINLRIERGELVAVIGASGAGKSTLLHILGLLDRPTKGTVLFEGQDVLRLSESAQADFRNRRIGFIFQFHHLLPEFTALENACMPALIQRKRLTEVEDRAVALLNDVGLGARLHHKPGELSGGEQQRVAVARALLMEPDLVLADEPTGNLDTHTGDALFGLMRDINKARGTTFVIVTHNDKLSAQADRIIHIQDGLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8N7</accession>
    <name>A0A1W1I8N7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49382">
        <property type="protein sequence ID" value="SLM49382"/>
        <property type="gene ID" value="NSJP_3215"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3215"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="98" mass="10160" checksum="1BE3A9EFA76CFEE4" modified="2017-06-07" version="1">MGARPVLRGATRPQRHGDVVGAGSGRLRSADATVVDDALEVGLGAAGSLYLAPDRFMLIVIRLGRESPSGARVVEIRGLSPVGQGDHEGLVASVLTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8P3</accession>
    <name>A0A1W1I8P3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49418">
        <property type="protein sequence ID" value="SLM49418"/>
        <property type="gene ID" value="NSJP_3251"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3251"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="61" mass="6921" checksum="E472FF6BF199FC9E" modified="2017-06-07" version="1">MFLMLGFSILTGGGFLVSNFEFAMCYLGLVFEFLALVGNWDRHRRRRRSQSHPDSVAPAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Q6</accession>
    <name>A0A1W1I8Q6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49249">
        <property type="protein sequence ID" value="SLM49249"/>
        <property type="gene ID" value="NSJP_3082"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3082"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="146" mass="15582" checksum="27C26572E43C8A8D" modified="2017-06-07" version="1">MRTRADNGRSIWHWCRMILWLAAAHEEGSAMKRVLLVLSMVAAASLAQAQLDGGVLISPGLSTVFVSPAFNGSANVLRPNQSSLFFNPPSSGSTITRGSDQPSYYIPLSPPPISGFRTTPYGIVMPGHPSVLDRPLAPFGITLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8U0</accession>
    <name>A0A1W1I8U0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49341">
        <property type="protein sequence ID" value="SLM49341"/>
        <property type="gene ID" value="NSJP_3174"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3174"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="690" mass="73267" checksum="66AEC581B039CC6A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Y1</accession>
    <name>A0A1W1I8Y1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49445">
        <property type="protein sequence ID" value="SLM49445"/>
        <property type="gene ID" value="NSJP_3278"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3278"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010742719" evidence="2">
        <location>
            <begin position="24"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="249" mass="28553" checksum="BFAB62C58B56DFC6" modified="2017-06-07" version="1">MRVPILVLVFLVFAALSTLSCSGKPSPHATEEPPPSTGHVDTEDDLMHGDHEAEAVLAMSNPQTHLGPHFRWTTLRPTNQADQATAWDFLRHLRQDLAPFREYRFAEDEGYETFLPNVRQTHYHFTRKTNGFKANFKFDPKQPTSLLYRDAPGGYELEGAMFTAPKWASEEDLNKRIPLSVAQWHAHVNICLPQKKDLQHADWKKFGPKGSILTKAECDQANGRFYPQLFGWMVHIYPYAETPEQIWAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9G2</accession>
    <name>A0A1W1I9G2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Outer membrane protein TolC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3510"/>
    <dbReference type="EnsemblBacteria" id="SLM49677">
        <property type="protein sequence ID" value="SLM49677"/>
        <property type="gene ID" value="NSJP_3510"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3510"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028351">
        <property type="entry name" value="CyaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001892">
        <property type="entry name" value="CyaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012076992" evidence="2">
        <location>
            <begin position="27"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="453" mass="49849" checksum="6A991005DCE1CB09" modified="2017-06-07" version="1">MRTAFIRRTGPLAVLLMFGMSATAWSQSSTEPFEQGSFLALQQAIELALKHHPVVQEANANLKASEARTQQTRSMYYPQIFANADTVAGAGRTNPRFLVGGALLQENQTIFTGGVVANQRLYDFGFTSNLVDSAKLAERAQGQDVNARRALVIVQVQRAYLISLKRQRLVRISEERVRERGIITGQIEILHRQQLKSKLDLDLMRVELVNAESSLIRSRNDLKSSFADLNRAMGVAGREDYVLEDLAVTVTPPKPLESLVSDSLSHPEIQRLKEQTASAEAKLVATKRQYLPTINAIGSGGAFEPFDPRQNQQTGGWWMAGALISMPLFTGFLIENQVVEATAQKEAAAAASMNIEQALTQQVTNSYLDTMTFSQQIKLGEELVKTAQEAQQLSKQRYKLGLGSIVEVTQAEVALTAAQTRLAESQYDYKIAEVTLAYASGGSAQLQIDPTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9J1</accession>
    <name>A0A1W1I9J1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49660">
        <property type="protein sequence ID" value="SLM49660"/>
        <property type="gene ID" value="NSJP_3493"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3493"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009770">
        <property type="entry name" value="DUF1338"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SMART" id="SM01150">
        <property type="entry name" value="DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="42"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="198" mass="22295" checksum="4E2DFACEB1C17134" modified="2017-06-07" version="1">MDRNLELDRLLEKMVAAYLQRNVAAATLKQMLDRVGVGFTPVIDHLTLRTANIDKRATPFVALGYAYDETLEFDDWYAKVYRKDGYPALFVDQAYPDGRGKTSIIPGWVDQFGDEHFHHIAVRVEDIEIAIERLKSQGIVFAGKIVGAQGEQLRQIFSAPEMVGGHPFSVLELAERHRGYRGFLPPQADSLMKSSTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9M8</accession>
    <name>A0A1W1I9M8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized HIT-like protein aq_141</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3464"/>
    <dbReference type="EnsemblBacteria" id="SLM49631">
        <property type="protein sequence ID" value="SLM49631"/>
        <property type="gene ID" value="NSJP_3464"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3464"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="114" mass="12361" checksum="FE29A310BA8EE7E0" modified="2017-06-07" version="1">MGDCLFCKIVDKKIPTAVVYEDDHTLAFDDINPQAPVHTLVIPKRHVDSVHVLDAKDEALLGRLLVSCNQVAGLKGLTAAGFRLVTNAGKDGGQTVPHLHFHVMGGRRMTWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9V2</accession>
    <name>A0A1W1I9V2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_3386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPF0758 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3386"/>
    <dbReference type="EnsemblBacteria" id="SLM49553">
        <property type="protein sequence ID" value="SLM49553"/>
        <property type="gene ID" value="NSJP_3386"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3386"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00608">
        <property type="entry name" value="radc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="102"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="240" mass="26034" checksum="5E7A745090FB6639" modified="2017-06-07" version="1">MGISHWPEAERPRERLLARGAAALTDAQLLAILLRVGRQRSTAVDVGMDILHHVGGLSGLAQCGLEELCAVPGVGEAKAAQLKAALELGRRAMAMPLSKGTRISSSRDLFNHFHSSLRDLRHEIFKVVLLDAKHGIVRETTVSEGSLTLSIVHPREVFSLAVKESAAAVIFLHNHPSGDPTPSREDRLLTARLVAAGEILGIRVLDHLVIGDGHYVSFADQGWLHRSDKTDLTPEEAIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9X5</accession>
    <name>A0A1W1I9X5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49824">
        <property type="protein sequence ID" value="SLM49824"/>
        <property type="gene ID" value="NSJP_3657"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3657"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="91" mass="10040" checksum="502CA05510E9ECE2" modified="2017-06-07" version="1">MFNWSSYRCLTLDVTGDHLLMNSETAAMKPAISFPEAHPYWSGLVLGAVTIPVPRATRAARSAMGGALARHDRGSLCGIRRARRPARREPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA68</accession>
    <name>A0A1W1IA68_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49948">
        <property type="protein sequence ID" value="SLM49948"/>
        <property type="gene ID" value="NSJP_3781"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3781"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="81" mass="9575" checksum="D466FC59C7F0B6FF" modified="2017-06-07" version="1">MSIENWTVQTTNGQNWGYIKRLILDSDTREISHADVILAKTGRLIRLPWRSFEVRDGWIKLRISERPVRSRRQSHLSSREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAH1</accession>
    <name>A0A1W1IAH1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Nitrite transporter NirC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3880"/>
    <dbReference type="EnsemblBacteria" id="SLM50047">
        <property type="protein sequence ID" value="SLM50047"/>
        <property type="gene ID" value="NSJP_3880"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3880"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="PTHR30520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM50047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="290" mass="30404" checksum="DCC5892693D6D194" modified="2017-06-07" version="1">MMDYVKPHDVVKDMVSTGALKLDVPASHLVIRGALAGAYLGIATSMAVTAAVETGSWLVGSLLFPIGLCIAILLRTEIITGSFALLPCATAAGKENACVSRVLVNWGWVFLGNLLGSVVYAAMLAIVLTTAGDAGLSATGTKLIAIAEAKTNYYASHGSAGMLTVFTKAVLCNWMVSLAVVFAFATTSLSGKILAIWGPTLLFFSQGFEHAVVNMFVIPVGMLLGAHVTLADWWIWNQIPVTLGNLVGGMVFTGLAIYFTHRTPATAPVVQAPVESATVPEHGRGYSPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB39</accession>
    <name>A0A1W1IB39_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50131">
        <property type="protein sequence ID" value="SLM50131"/>
        <property type="gene ID" value="NSJP_3964"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3964"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="67" mass="7737" checksum="5869DBF8B912366E" modified="2017-06-07" version="1">MRMRLKLGPSLDSAPQGQVRLRVLLLVLRDHGLQGGHHLLLYGSFSINFVRGRRLLRFGTVSDRRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB54</accession>
    <name>A0A1W1IB54_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Polysaccharide export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_4069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4069"/>
    <dbReference type="EnsemblBacteria" id="SLM50236">
        <property type="protein sequence ID" value="SLM50236"/>
        <property type="gene ID" value="NSJP_4069"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4069"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="128"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="213" mass="23048" checksum="9AF0D5D76C209DB0" modified="2017-06-07" version="1">MGVVKSIFSGKRNGKGRLIAGLLVLLLQYSMVGCQSQDMQYRGSSVPPTEFLIGPEDVLVVTVWRNQDLSKEVIVRPDGKISLPLIGDITAAGLTAQDLSKQVADKLAEYMSTPTVSVQVKEINSYHVFVVGEVAKPGKYVLKSFASVLQGISYAGGFTTFASRNNVHVLRMVKNGQGETKQVMIPVPYQDIVQGRNLEANIVLKAGDVIVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB71</accession>
    <name>A0A1W1IB71_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotase</fullName>
            <shortName evidence="5">DHOase</shortName>
            <ecNumber evidence="5">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">pyrC</name>
        <name evidence="7" type="ORF">NSJP_3994</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3994"/>
    <dbReference type="EnsemblBacteria" id="SLM50161">
        <property type="protein sequence ID" value="SLM50161"/>
        <property type="gene ID" value="NSJP_3994"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3994"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="51"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="323"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM50161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="425" mass="45022" checksum="6E933608EF369844" modified="2017-06-07" version="1">MTIFITGGHIIDPGRYNGVGDVLINQGRIAALGSALDAPLHAKKISAKGRLVVPGFVDLHVHFREPGFEYKETIQSGAAAAVAGGFTTVCCMPNTNPVNDNQAITEFMLERARAAGLANVLPIGAITKGSEGKELAEIGDLRRAGCVAISDDGKPVMNSLVMRRAMEYALAFDIPVVDHCEDLHLAEGGCMNEGLISTELGLPGIPSAAEDVMVARNVALAELTGARLHLAHISTEGSVRMVREAKARGIRVTAEACPHHFTITEESVRGYDTCAKMNPPLRTWKDVQAIKQGLRDGTIDVIATDHAPHATQEKQQGFTEAPFGIVGLETALSLTLALVEEGVLTLEDAVAKLSTAPAAAFGLKKGTLAVGADADVTIVDSQAQWEVDPIKFRSKSRNTPFAGWKVKGRVCTTIVGGKIAFDTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB94</accession>
    <name>A0A1W1IB94_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative N-acetylmuramoyl-L-alanine amidase AmiB</fullName>
            <ecNumber evidence="3">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_4109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.28" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4109"/>
    <dbReference type="EnsemblBacteria" id="SLM50276">
        <property type="protein sequence ID" value="SLM50276"/>
        <property type="gene ID" value="NSJP_4109"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4109"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="2">
        <location>
            <begin position="267"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="429" mass="46455" checksum="73987B535BF973A3" modified="2017-06-07" version="1">MSSFVMPLALWRILVIAVAINLTGPGCYDAPGPATASAESTRSAPDQPSGSKRSRNSRISMTPTTLGITTIHNLRTTVSPDVTRLVLDLDHATRTPAKPALQTEGIVIEIPRAALGKSAQAKLTRGSLAKPFIITQGSDNSVSIALPAGTFESYRLLSLSNPPRLVVDVVPSKHMDISPGPDQVEVPLPFSPPAQPVPPRAKPFTTVVIDPGHGGKDPGAHGQRGTEEKDITLKVALKVRDLLAKEPGLRVLMTRERDVFVELEDRAKFANGNEADLFVSIHVNSHPQRSVRGIEIYHFGEAKDQRALEVAARENGTPLGSTGAGWEYLVADLLTTRKIEASLELAWTAKEAMVSHLNGHYSLVDHGVKTAPFYVLRYTSMPSILAEIAYISNSAEEELLRNQTFTTRVAESLHEGVRVYLAASKQPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBD4</accession>
    <name>A0A1W1IBD4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Lipopolysaccharide heptosyltransferase III</fullName>
            <ecNumber evidence="2">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4167"/>
    <dbReference type="EnsemblBacteria" id="SLM50334">
        <property type="protein sequence ID" value="SLM50334"/>
        <property type="gene ID" value="NSJP_4167"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4167"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="194" mass="21412" checksum="F464385165070242" modified="2017-06-07" version="1">MAGRTPRLWLTPEEERRAADVLSRERVEGAKPLVMLQPGARYWFKAWPWERFAALADRLAEQYGYQVLIGGNQQEFELAERICGAVANRPINLAGRADMRTYAAILKRASLFVGNDSGAMHVAAAVGTPVVALFGPSDPKEWGPRGGAVAVLYKGLDCRICFHPTCERGEENCMKLIGIEEVLSAIGRLRTIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBG2</accession>
    <name>A0A1W1IBG2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_4163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4163"/>
    <dbReference type="EnsemblBacteria" id="SLM50330">
        <property type="protein sequence ID" value="SLM50330"/>
        <property type="gene ID" value="NSJP_4163"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4163"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="3">
        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="537" mass="58614" checksum="B0FCACB553B177E8" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZT9</accession>
    <name>A0A1W1HZT9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46242">
        <property type="protein sequence ID" value="SLM46242"/>
        <property type="gene ID" value="NSJP_0070"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0070"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="94" mass="11346" checksum="2B3DE75A22742E64" modified="2017-06-07" version="1">MAGDGAKGIYDHLYRRFFERRNTHQGYDFQHAPGGSVRPPVVTFRDKLHWWTWNRWQRRKEILRERDQRQRDIVDLGQPRSIMTMTNEGNTSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZZ4</accession>
    <name>A0A1W1HZZ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Response Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0156"/>
    <dbReference type="EnsemblBacteria" id="SLM46328">
        <property type="protein sequence ID" value="SLM46328"/>
        <property type="gene ID" value="NSJP_0156"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0156"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="10"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="166" mass="18155" checksum="E8B5B117F2051EC2" modified="2017-06-07" version="1">MPTFAAQTQTVLVVDDDPGVLSLCRTLLERAGFSVLPAAGSSEALKICKHHSGTIDIMVTDLVLPPPEFSFASGGNEFPHVHGHELAVRALGMRDNLRILLMSGNVEKDLAGYGIRKGSLPFISKPFDNVALIDLVRRTLQEAPPTKESLLQEHQDKHNGTDEWFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I046</accession>
    <name>A0A1W1I046_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46259">
        <property type="protein sequence ID" value="SLM46259"/>
        <property type="gene ID" value="NSJP_0087"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0087"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="279" mass="31409" checksum="C01EB700034DC658" modified="2017-06-07" version="1">MARFRPKQTIKLVNQLVRLNGAAEAVSWTDEPVLPREFRERYAMLQRQCRDQSSHLRLGRLIHRLMQYDYGVRESALAEMELASQLIRVGAAVIFLPESQAKTADLECRVGSDRFFVEVTAMVGSRTPRRNPIAGLAHEGDNLPDRGAILIHRVLARVRQKAKQLADYVDPVVLSLSIPRAELQGAGWIRRRNVSLDLRAMAGSTTMLLTGLRHLSAVLITLWDVEPLPVSAATRLANVDVHERNGRQAGHPRVRLLIRNPSAATPLTERQRDSFDRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0B0</accession>
    <name>A0A1W1I0B0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0111"/>
    <dbReference type="EnsemblBacteria" id="SLM46283">
        <property type="protein sequence ID" value="SLM46283"/>
        <property type="gene ID" value="NSJP_0111"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0111"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="132"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="312"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="592" mass="68064" checksum="DE9040725A6D027C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0E7</accession>
    <name>A0A1W1I0E7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46475">
        <property type="protein sequence ID" value="SLM46475"/>
        <property type="gene ID" value="NSJP_0303"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0303"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="34" mass="3706" checksum="1017BE58BB2C98BE" modified="2017-06-07" version="1">MNSTYVEPVLNLEIWSYSLIPTGKSFHSASYGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0J4</accession>
    <name>A0A1W1I0J4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46511">
        <property type="protein sequence ID" value="SLM46511"/>
        <property type="gene ID" value="NSJP_0339"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0339"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012303276" evidence="2">
        <location>
            <begin position="24"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="163" mass="16209" checksum="C693D4745B8916DB" modified="2017-06-07" version="1">MRISEQRAIVFAAFLGLMAGGCASDGTTGSGNGATAGSTPSSAPAAAPSSAPAASSAAGTAPKFATAEAAAKSVQTDTLRNCLAMIPANATPGAKQVAEESCKRDEQLRANVVGMASTKSGDRAASGTQGDTLDACMARIPKDASAGQRMLAEQSCQRDQANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Q2</accession>
    <name>A0A1W1I0Q2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4136 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46562">
        <property type="protein sequence ID" value="SLM46562"/>
        <property type="gene ID" value="NSJP_0390"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0390"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025411">
        <property type="entry name" value="DUF4136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13590">
        <property type="entry name" value="DUF4136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4136" evidence="1">
        <location>
            <begin position="37"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="168" mass="18956" checksum="23A8DABEA85CEF7E" modified="2017-06-07" version="1">MNIRFLILWLALGLLTAGGCSKVKAWYEDTRYEVHARTNFEPSADFSSFHTFAHSGMTDRGRKIAATDNNSPLRARVKEIVNKQLVAKELRQVGLEDHPDLLVHLLFGMMDADKYQEATLVVNLTESSKKKLVWQAVINETVGDSLEKNFEMIDKGVAKAFKDYPPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0R2</accession>
    <name>A0A1W1I0R2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">purA</name>
        <name evidence="11" type="ORF">NSJP_0400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0400"/>
    <dbReference type="EnsemblBacteria" id="SLM46572">
        <property type="protein sequence ID" value="SLM46572"/>
        <property type="gene ID" value="NSJP_0400"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0400"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
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        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
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        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
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        <property type="entry name" value="Adenylosuccinate_synthetase"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="299"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="331"/>
            <end position="333"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="413"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM46572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="436" mass="47707" checksum="0E93E22C26D36FAE" modified="2017-06-07" version="1">MSNLVVIGAQWGDEGKGKIVDILARDADVVVRYQGGSNAGHTVINQNGTFIFHLIPSGILYRGTLCVIGNGVVVDPAALIEEMDHLGGQGVHIGKNFIISQRAHLILPYHKAIDKASEQSKGSRRIGTTGRGIGPSYADKMSRIGIRVGDLLNPKTFRTKLEENLIEINWFLEQLYKVERFEVEKVFQQYMSYAERLKSHIADAVTRVNKMIDNRKTILFEGAQGTHLDVDLGTYPYVTSSSATAGGAATGSGVGPTKIDAVLGVAKAYTTRVGSGPFPTELSDEVGRGLQERGKEYGSTTGRPRRCGWFDTVVMRHATKVNGLSSLALTKLDVLDGCKELKVCTAYRYQGALSKDMPADLQALQESEPVYKRFKGWSASTTGLTTYGRLPVEAKRYLEYIAEQAECPIDMVSTGSKRDATIILKNPLKASSRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I127</accession>
    <name>A0A1W1I127_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Deoxyhypusine synthase</fullName>
            <ecNumber evidence="2">2.5.1.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0533"/>
    <dbReference type="EnsemblBacteria" id="SLM46705">
        <property type="protein sequence ID" value="SLM46705"/>
        <property type="gene ID" value="NSJP_0533"/>
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    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008612">
        <property type="term" value="P:peptidyl-lysine modification to peptidyl-hypusine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
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        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="PTHR11703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="369" mass="40829" checksum="D6B67402E8A74D38" modified="2017-06-07" version="1">MGAREFRDGAQDGLEALEPLDPEAITSFDGLLTAMRKTAFGGRRLGEAYEVLSAMIEDPDCSVVMTLSGAMTIAKMGKIVSTMIDHGMVQCVVSTGALIAHGLSESVGKTHYRHHPSMSDEELFRKGYNRVYDTLEMESNLNYVEHVVGQTMKRIDPNQPLSSELLTRELGRTLADEFDGAGILKSAYLKKVPVYIPAFTDSEMGLDVGTWAMGRVVDQARAQTKDGTDLDILRTINKSYPSFNPYQDLNSYTTHITSAKRLGIFTIGGGVPRNWSQQVGPYVEISNMRLGLKVRPPRFHYGVRICPEPDYWGGLSGCTYQEGISWGKFVSPEEGGRFAEVLSDATVVWPLLMVGLLERMKLKRTARKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I186</accession>
    <name>A0A1W1I186_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0595"/>
    <dbReference type="EnsemblBacteria" id="SLM46766">
        <property type="protein sequence ID" value="SLM46766"/>
        <property type="gene ID" value="NSJP_0595"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0595"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="225" mass="24506" checksum="660F18597AD0BB6C" modified="2017-06-07" version="1">MSPKSMRGQTIPNDPLRATHSTRLQRQTDGWFQRAEAALLGAVPCRAGCSHCCIGPFPITVLDVQALHEGLARLEPHDREEIQRNAAEQTAVLEQAAPSLKQAPFVDQFADAETDRLVTLLEDAPCPALSAEGLCRVYDHRPLTCRSMGIPVVEPTGTFGACAVQTFVPIRRLPASLREEEETLAAQEAVALHQIRLSSPTPGEEVLLPYGFLPSLHTIAGRSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1B2</accession>
    <name>A0A1W1I1B2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46790">
        <property type="protein sequence ID" value="SLM46790"/>
        <property type="gene ID" value="NSJP_0618"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0618"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="84" mass="9397" checksum="AC7DD169EBE12DB9" modified="2017-06-07" version="1">MSQWGHSMKSVVYEGYTIKSFPQQHLKSGQWKISLDIFWEAHGVTTVKCFTAETHYATEEDADLNGSTYGQDIIDGKVPGLSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1F7</accession>
    <name>A0A1W1I1F7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit c</fullName>
            <shortName evidence="13">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">atpE</name>
        <name evidence="15" type="ORF">NSJP_0491</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_053381401.1">
        <property type="nucleotide sequence ID" value="NZ_LT828648.1"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0491"/>
    <dbReference type="EnsemblBacteria" id="SLM46663">
        <property type="protein sequence ID" value="SLM46663"/>
        <property type="gene ID" value="NSJP_0491"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0491"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="PTHR10031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="13">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SLM46663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="76" mass="7807" checksum="2FCF2ACB6438C63C" modified="2017-06-07" version="1">MDSAAAALLGMGLAAAGFAGAGVGIGYIFGKMIEAVARQPEAEGRVGKYMWIGFALVEAIALYGLVIAFIIMGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1F9</accession>
    <name>A0A1W1I1F9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46822">
        <property type="protein sequence ID" value="SLM46822"/>
        <property type="gene ID" value="NSJP_0650"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0650"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="122" mass="13588" checksum="997D081AE8326653" modified="2017-06-07" version="1">MTLIRNVCLVVLCVVLSGLEPHLEQSASANDVGMRVETALREAAKDVDHRHRESTDRAILDITYLIEQSWKAKEHSRDGARKDYAAQARALIVREARMGHLDIVKTGSVLKLLEELLSDQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1K9</accession>
    <name>A0A1W1I1K9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0718"/>
    <dbReference type="EnsemblBacteria" id="SLM46890">
        <property type="protein sequence ID" value="SLM46890"/>
        <property type="gene ID" value="NSJP_0718"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0718"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="374" mass="41485" checksum="171D52B951809895" modified="2017-06-07" version="1">MRYLSFGSGVATVLILISCGLTSAAQERKPSELKHSPAGAERHLKNIRQLTFGRQNAEAYFSFDGTKLIFQSTNNWTRESFAATLRPAEAGLNCYQMYVMDLESQTIRLVSTGTGATTCGYFFPGDRRVLFSSTHASGPNCPAKPKRDGAYRWALDDYDLYAVRIDGQEMQRLTTSPGYDAEATVSPDGKTIVWTSVRDGDLDLYAMNLDGTKPRRLTDEVGYDGGAFFSPDSKRIVYRASHPTEPAEVARYKELLDQRLVEPGQLEIAVMNADGSGKQQVTSNGASNFSPFFHPDGKRIIFSSNVETRGDGGRPSFHLYLVGDDGTGLERLTFEGQFNSFPMFSPDGKRLVWVSDRHAKQPGEFNVYLAEWVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1L2</accession>
    <name>A0A1W1I1L2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Neisseria_PilC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0726"/>
    <dbReference type="EnsemblBacteria" id="SLM46898">
        <property type="protein sequence ID" value="SLM46898"/>
        <property type="gene ID" value="NSJP_0726"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0726"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008707">
        <property type="entry name" value="PilC_beta_prop_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05567">
        <property type="entry name" value="Neisseria_PilC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012574130" description="Neisseria_PilC domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="domain" description="Neisseria_PilC" evidence="2">
        <location>
            <begin position="1150"/>
            <end position="1307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1794" mass="190341" checksum="22B087065DF30D61" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1P6</accession>
    <name>A0A1W1I1P6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Type IV pilus assembly protein PilV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0729"/>
    <dbReference type="EnsemblBacteria" id="SLM46901">
        <property type="protein sequence ID" value="SLM46901"/>
        <property type="gene ID" value="NSJP_0729"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0729"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013362">
        <property type="entry name" value="Pilus_4_PilV"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02523">
        <property type="entry name" value="type_IV_pilV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="176" mass="18867" checksum="0BF32DA26C7A8BDA" modified="2017-06-07" version="1">MLITELETRVARRDINGSEWGFTLIESMVAALILAVGLLALSGMQAMSLKRNINGNEMTRVSNLAADMVERIQFNRRNVTAYHNINVSSAVTTCPASTVNVMANGDCVQWRTLLLNSGLSNIAGTVVLNPAPPALDPLGLTRSTVTVRLDWMANSNIGSASLMPKSITLVTVVAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Q9</accession>
    <name>A0A1W1I1Q9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0627"/>
    <dbReference type="EnsemblBacteria" id="SLM46799">
        <property type="protein sequence ID" value="SLM46799"/>
        <property type="gene ID" value="NSJP_0627"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0627"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="240" mass="27597" checksum="D5A2CB586BA401C4" modified="2017-06-07" version="1">MDCFGLGGFLLKEEDIPSLKTAHERFCNSWNINYPLHSSSIRGKRGRFSWLRSMERADQFLSELEHLLVSLPGIAIACVIHRPGYVSRYREMYPGQLWFMCKTAFSILVERSAKFSDGQGRKLEIVFEGTGKKEDRNLKHYLKELKRNGSPFSTQTSHGYTPLVADDFRRIILGELHQKTKEVPMLQLADLLLYPMAKAGYEPSYGPFVRLKEAGRLIDCYFTAEECSSRGIKYSCFERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1U8</accession>
    <name>A0A1W1I1U8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46986">
        <property type="protein sequence ID" value="SLM46986"/>
        <property type="gene ID" value="NSJP_0814"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0814"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="39" mass="4567" checksum="ABCFEE36E4DF6653" modified="2017-06-07" version="1">MMQSMSLGLRLREGLAYPVKRGSEGSLSIWWRNEDAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Y0</accession>
    <name>A0A1W1I1Y0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46869">
        <property type="protein sequence ID" value="SLM46869"/>
        <property type="gene ID" value="NSJP_0697"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0697"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="59" mass="6846" checksum="334309FAEDCADB2C" modified="2017-06-07" version="1">MEEAPSERAQSHRGILKKEEFLNYVICRAEWHDSSRQPVWGGQPVCVSPHNYNADFSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Y1</accession>
    <name>A0A1W1I1Y1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0835"/>
    <dbReference type="EnsemblBacteria" id="SLM47007">
        <property type="protein sequence ID" value="SLM47007"/>
        <property type="gene ID" value="NSJP_0835"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0835"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="141"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="492" mass="54954" checksum="D58FBAFC0C3E4FF1" modified="2017-06-07" version="1">MPPQRTGTSGPVIKGSLSETPIPTRNVSNGEFLPVPQTLHQRHVEYRAQRLADRAAQRLGVSRREFLRGTGGLAAVLLAMNGVFGRFFGIGPVELFEPSAFAEQRGDPYFIFDVQNHYVSSEYDPSDAESQRKGAVSKQALIALRRRVRETGVNPALTGDRGTIDDLSWRNFVKEVFLDSETSIGLISTPPGPYPQAAVVPPREMAHIRDEINRLAGSRRMLAHGLATPQLGSADLDFMAMQAETLGVEAWKCYTGACPKGFERGWWMDDEAVAYPMLEQARKLNVKRVCVHKGLPLGPVPDYNHPKDLIKAAKDFPDITFLVYHSGFKTVAGIDDVFARSGEIPWTTEFCSMKKHEPGLTNIYMELGSTFAQLVTAHPGTCAHLIGQIVEAFGVDHVLWGTDSIWSGSPQWQIEAFRRFQMPDEFIERYRYQPLTRDVKAKIFGLNAARVFDVDVTATRLDVPRDYLGRMRMSYLEEGPLPSHRLYGWVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I215</accession>
    <name>A0A1W1I215_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47034">
        <property type="protein sequence ID" value="SLM47034"/>
        <property type="gene ID" value="NSJP_0862"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0862"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="55" mass="5950" checksum="2B53D5D175DFEC06" modified="2017-06-07" version="1">MPQLRKSIGSVSDPHDNIPLGAFHQCAMEGEVTGIGLDRLCLFDIVHSGAYAFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I230</accession>
    <name>A0A1W1I230_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative pterin-4-alpha-carbinolamine dehydratase</fullName>
            <shortName evidence="4">PHS</shortName>
            <ecNumber evidence="4">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pterin carbinolamine dehydratase</fullName>
            <shortName evidence="4">PCD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_0859</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0859"/>
    <dbReference type="EnsemblBacteria" id="SLM47031">
        <property type="protein sequence ID" value="SLM47031"/>
        <property type="gene ID" value="NSJP_0859"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0859"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTHR12599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="116" mass="13105" checksum="70B7274B7F8A3F24" modified="2017-06-07" version="1">MKLANKKCNDSVTVPTLTMRQARGVLKHLARGWRINRNGRLQSQYVFMNFAKALAFANKIGVIAEAEKHHPDLYVAWGKCKIEIWSHKVKGLTESDFVLAAKCDRVSKPSPTRSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I248</accession>
    <name>A0A1W1I248_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">ftsY</name>
        <name evidence="7" type="ORF">NSJP_0721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0721"/>
    <dbReference type="EnsemblBacteria" id="SLM46893">
        <property type="protein sequence ID" value="SLM46893"/>
        <property type="gene ID" value="NSJP_0721"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0721"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="6">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="111"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="193"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="257"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="308" mass="32760" checksum="3E168C21D32060EB" modified="2017-06-07" version="1">MGWIQRLNKGLTRTRSAVRGSLDKLLRRSADPALLEELETALILSDLGSPVVTRTMDHLRQGLLGTNASQSHTVQTVLKQTLLQALAPATGPTLDDLITRGSKPFVILAVGVNGVGKTTTLAKIAQRLVNGGLKPVLVAADTFRAAAIDQLKVWSDRIGAEFVSHRHGADPAAVAFDGLMAAKARNADVVLIDTAGRLHTKSNLMDELRKISRVLKQGMPEAPQEVLLVIDATVGQNALVQARQFNQAVGITGLVLTKLDGTARGGIVVAIADELKLPVRLIGVGESAEDLQDFHPEPFVDALIGTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2F5</accession>
    <name>A0A1W1I2F5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="8">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">hisS</name>
        <name evidence="10" type="ORF">NSJP_1002</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1002"/>
    <dbReference type="EnsemblBacteria" id="SLM47174">
        <property type="protein sequence ID" value="SLM47174"/>
        <property type="gene ID" value="NSJP_1002"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1002"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="22"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="418" mass="46443" checksum="21771B5D8504C774" modified="2017-06-07" version="1">MIKGIRGVKDILPEETPRWRFIEETARRWAERCGFHEIRLPIFEATALFARSIGATTDIVEKEMYTFPDRDGTLLTLRPEGTAGTVRSFVEHNRGADPLPQKYYYLGPMFRHERPQAGRLRQFHQFGVEYFGTQDARADVEVMSLLWRFLSDLTLPDLTLEVNSLGTAADRAAYLPVLVAFLKGRTDRLCANCLRRIDTNPLRVLDCKVPECRAATDDAPRLTDHLSPEARTHFAEVLAGLTSLDIPYHLNARLVRGLDYYCLTAFEVTSSHLGAQNAVGAGGRYDGLVETLGGPHTPAIGFAAGLERISLMLPDTTQPVTVPSVYVASFGTDGAPAGIRVLDALRRAGLVAQTDYRSTTLKAHLRQADRARSRWAVLLGDDEVRRGSVIVRHMGTKAQAEVPFSEIPRHILAQLSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2H0</accession>
    <name>A0A1W1I2H0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Quercetin 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_1013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.24" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1013"/>
    <dbReference type="EnsemblBacteria" id="SLM47185">
        <property type="protein sequence ID" value="SLM47185"/>
        <property type="gene ID" value="NSJP_1013"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1013"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008127">
        <property type="term" value="F:quercetin 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="31"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="4">
        <location>
            <begin position="194"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="298" mass="32247" checksum="EBE0EAA7A62630B5" modified="2017-06-07" version="1">MNRPAAITTAQTKELRGIYHAGSQHMVGDGFPVRNMIPGAGVEEQLSPFLLLDYMGPEYFPPTNRRLGVGEHPHRGFETVTIMYQGKVAHRDSTGSGGVIGPGDVQWMTAASGIVHEELHEEEFAKRGGTLEGIQLWVNLPKSFKMSQPRYQTLVSGEIPAVDLGGGAGRLRVIAGEFRGQRGPAKTFSPVHLYDLRLNGGHSIDLSLPEGFNTSVFVLHGRVVINGTRPAGEAELALFGHSGERITLDATEDSVILILGGEPIEEPIARHGPFVMNTQAELVQAVNDYRAGRMGHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2H1</accession>
    <name>A0A1W1I2H1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47171">
        <property type="protein sequence ID" value="SLM47171"/>
        <property type="gene ID" value="NSJP_0999"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0999"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="80" mass="9048" checksum="41DBF4B1C1B2DF0D" modified="2017-06-07" version="1">MATLTIKNIPEPLVKRLKQQAAAHRRSLNFQVISYLEQMTHSIPIDADALLARARALRRTPKGMKLTDRILDELKVAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2M6</accession>
    <name>A0A1W1I2M6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1085"/>
    <dbReference type="EnsemblBacteria" id="SLM47257">
        <property type="protein sequence ID" value="SLM47257"/>
        <property type="gene ID" value="NSJP_1085"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1085"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="15"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="222" mass="24345" checksum="69AAA09FA6D1B0E8" modified="2017-06-07" version="1">MTKIFRDREEAGYRLGQRLLAYRDNPDGLVFALPRGGVIVGYQLSLALHLPLEVFIACKVGSPENPEYALGAITEMGNLHMNPIYAGDHRRLTTSVEELAEEKRAEILRRRQLYRQGRSLLAPTGRLAILVDDGIATGATFLAAVEALREQAPSRLVAALPVGPAETVEQVRGLVDELVVLACPEPFWSVGTHYADFSQINDEEVLTCLDLANARHDGTVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2N3</accession>
    <name>A0A1W1I2N3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Sulfite:cytochrome c oxidoreductase, subunit A</fullName>
            <ecNumber evidence="6">1.8.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.2.1" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1095"/>
    <dbReference type="EnsemblBacteria" id="SLM47267">
        <property type="protein sequence ID" value="SLM47267"/>
        <property type="gene ID" value="NSJP_1095"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1095"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050310">
        <property type="term" value="F:sulfite dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_molyb" evidence="4">
        <location>
            <begin position="93"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Mo-co_dimer" evidence="5">
        <location>
            <begin position="284"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="400" mass="43968" checksum="867B8F25554EE7CD" modified="2017-06-07" version="1">MSLGGSDSIVSRRTWLKRLLAGIAAARLLAETRLKSAAAGEVGDIPRDTGPLTIRVTRPFDAETPAREFVSFFTPNHRFFVRSHFGPPPERIAEAEWRLRIDGLVEAAKELTLGDIRQMEAVTVTAVLQCSGNGRAFYRPRIPGVQWERGAVGNAQWTGVRLRGILRQAGIRKNARHVQFQGADRPPVPSVPLFTRSIPLGKALHPDTLLAYEMNGRPLPLLHGAPLRVITPGWMADSCTKWLTDITLLSEESDGYYMRTAYRLPLDPIEPAMAGESDRTRPVEAMVVKSLIAAPPEGATVPLAPVMIQGAAWGGESKILSVEVSLDEGKNWQTARFVGEEHPYAWRQWQLVWTPRAPGPVSILCRATDETGTVQPLASPWNPGGFLWNGWDRVTVTVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2S4</accession>
    <name>A0A1W1I2S4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47179">
        <property type="protein sequence ID" value="SLM47179"/>
        <property type="gene ID" value="NSJP_1007"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1007"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="190" mass="21345" checksum="EA9BB727CB1480E4" modified="2017-06-07" version="1">MNDPNPQVIPPPRKKKPLDTVVKLALAVFFGSFGLIWGGMYLSRPDRSIPPYSVGSQEGTAVAVHVPAWTSDTEIETLIQRLRKVGRETRNFGPMKIRPTTPDDPTSRYRRITVYIFTHDAWAEAPILHGYLSGEDREIRDGFRRAMRGYYQLTDSEDEGRIGPLVDGPDTAATAAYSRQLFKEPLRPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2W9</accession>
    <name>A0A1W1I2W9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1176"/>
    <dbReference type="EnsemblBacteria" id="SLM47348">
        <property type="protein sequence ID" value="SLM47348"/>
        <property type="gene ID" value="NSJP_1176"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1176"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="131" mass="14438" checksum="EFDFD5B659FC0943" modified="2017-06-07" version="1">MTAHPVTVLLIDEQKEDRASLRRCFLDVGSHVRVFEASSGETGLDWVRAVQPDCIVLELRMRDVIGMEVLGRIQDELAGRRVPVVIWTVLSHVALRTTASALGVRAYIEKTRGSEQAVVEAVRECLTSPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I316</accession>
    <name>A0A1W1I316_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47365">
        <property type="protein sequence ID" value="SLM47365"/>
        <property type="gene ID" value="NSJP_1193"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1193"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="78" mass="8817" checksum="6A72944CC88AE6F3" modified="2017-06-07" version="1">MVHPVTSLFVIVRWKTVQKVENRGRKQEELSAGRCVAGTFVLMKADAMRNHSWGPPTRRSRNFSMRAHSEGLPVAGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I382</accession>
    <name>A0A1W1I382_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47421">
        <property type="protein sequence ID" value="SLM47421"/>
        <property type="gene ID" value="NSJP_1249"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1249"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="545" mass="61558" checksum="3B4E52496B3DF3A0" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I391</accession>
    <name>A0A1W1I391_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative stress response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yjbJ</name>
        <name evidence="3" type="ORF">NSJP_1131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47303">
        <property type="protein sequence ID" value="SLM47303"/>
        <property type="gene ID" value="NSJP_1131"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1131"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026042">
        <property type="entry name" value="YjbJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039008">
        <property type="entry name" value="YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD" evidence="2">
        <location>
            <begin position="4"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="76" mass="9001" checksum="8973B7D7BD92523E" modified="2017-06-07" version="1">MNADTFKGKWGQFKGELKRQWGKFTDDDLMQIEGNYEKFLGKVQERYGEQKDEISGWADTWFQGPKPDQVEKKPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3E3</accession>
    <name>A0A1W1I3E3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">xerC</name>
        <name evidence="13" type="ORF">NSJP_1350</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1350"/>
    <dbReference type="EnsemblBacteria" id="SLM47522">
        <property type="protein sequence ID" value="SLM47522"/>
        <property type="gene ID" value="NSJP_1350"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1350"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="12">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="11">
        <location>
            <begin position="110"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="9">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM47522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="317" mass="35256" checksum="BDD6DD8BE765EEA0" modified="2017-06-07" version="1">MDGAIRAFIAFLRAERRASPETLRGYTADLRQFHGFLLSHRLATIPVDPGVLSREAVRAYLQWLDRDGIRRSSLARKLASLRSFYRFLVRDGLVECDPTQDIRTPKQPKLLPRVLTKEEAAAVMTTSPDARPQSARDCALLETLYSTGARVSEVAALDLGDVRCSEGIVRLRGKGRKERLVPIGEVALRAIAEYLKQQPILLRTAGLSTGLRSPLFRNHRGGRLTTRSVARIVARHSSGLTGGPVSPHTLRHSFATHLLDEGADLRSIQEMLGHASLSTTQKYTHVTMDHLLAVYDKAHPRADPPARDPERKNSKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3K5</accession>
    <name>A0A1W1I3K5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YkuD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1402"/>
    <dbReference type="EnsemblBacteria" id="SLM47574">
        <property type="protein sequence ID" value="SLM47574"/>
        <property type="gene ID" value="NSJP_1402"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1402"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YkuD" evidence="3">
        <location>
            <begin position="66"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="210" mass="23208" checksum="06CD14A55D12FAA6" modified="2017-06-07" version="1">MKQGRSLLASGFVAFLLLSLAHSTLRIEPERSDASPTISDPAALLALQTRYRSLTRQLTQLTPSRPYIVVDTARNHLFIKRRDRIMLDAIASTGSGTILDKPGETAGQWIFDTPRGEFSVQSKLVNPVWVRPDWAFVEEGLAVPISQADRVEPGVLGAYALGFGKGYFIHGTLYPRLLGKNVTHGCIRLNDDDLKSVYQLARVGTPIMIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3V8</accession>
    <name>A0A1W1I3V8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetylglutamate kinase</fullName>
            <ecNumber evidence="7">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">NAG kinase</fullName>
            <shortName evidence="7">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">argB</name>
        <name evidence="9" type="ORF">NSJP_1351</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1351"/>
    <dbReference type="EnsemblBacteria" id="SLM47523">
        <property type="protein sequence ID" value="SLM47523"/>
        <property type="gene ID" value="NSJP_1351"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1351"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04250">
        <property type="entry name" value="AAK_NAGK-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041727">
        <property type="entry name" value="NAGK-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="298" mass="32172" checksum="717A3A4E9D45BA5D" modified="2017-06-07" version="1">MNKLIKKASVLIEALPYIRTFRGKTVVIKYGGNAMIESSLKERFAQDVVLLKYVGLNPVIIHGGGPQIDKMLDRLGIESKFLHGVRVTSEATMEIVEMVLAGKINMEITDLITRHGGSAVGLSGKDGGLILSKPLTAKAWAESLERDFDGDDAESDFGFVGDIEKVDPSLLLKLQGDHYIPVIAPIGTDREGNTYNINADLVAGAIAGALRAEKLVMMTDIKGIRDANGRHLSTVSRKDVQRMVKKGTITEGMLPKVHACLDALEQGAAKAHIIDGRTPHAVLLEIFTHKGIGTEITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I414</accession>
    <name>A0A1W1I414_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1391"/>
    <dbReference type="EnsemblBacteria" id="SLM47563">
        <property type="protein sequence ID" value="SLM47563"/>
        <property type="gene ID" value="NSJP_1391"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1391"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="67"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="305" mass="33276" checksum="BA787624A1DD059A" modified="2017-06-07" version="1">MDTDPMRNKIPCSAERLSLLDPPMIQGVVDRNAFHIGNQYLSENRVRIVEADDSQISSAVIGNSGLYEQTIKLKDGHLVSRCSCSLPEEPMCRHCIAVLLEYHRWVQPKSQSKKAKQPAASQAAAPEANGGGTPAAAAHGGPDLKLSEVMAFIEWLQPAMKAIGEGHSLPDSSRASGEIGAWIETIRGLDERRRESEERQSTMESERRDREAYVGRLTQQLQTSMAEVQTAQQASQQLQQEISTYQDMFAKIADLASEVAGYDSQIKSISGELLAKGAQLDKLAASFREVASALKTGQRPGPQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I488</accession>
    <name>A0A1W1I488_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1648"/>
    <dbReference type="EnsemblBacteria" id="SLM47820">
        <property type="protein sequence ID" value="SLM47820"/>
        <property type="gene ID" value="NSJP_1648"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1648"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025737">
        <property type="entry name" value="Phenol_MetA_deg_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13557">
        <property type="entry name" value="Phenol_MetA_deg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="342" mass="37464" checksum="8E5C90D7B86C789F" modified="2017-06-07" version="1">MLAMTLVSPGSAQSSCGSVSCFVVIGSQQQVSPAGVLTVNLTYNYTPNGLPPDGANTIPYANQQTKQLILGNTPVSNLETLVQTAALDLNYGLTERFGLQVMLPYKSVQSVGQFGPGTVSSFNDQGLGDILGKVKYNLLPTLRSMLVLEMGVYFPTGTYQQAGPNGQYAESTLQLGRGAFGFQPSFYQTYEILPHRLNQFLQGSWRYTLRNPDGYQFGQEYALNLGFNIVTVPWLTLTEQINFRYKTKDNIEAALYQLVGPPVNRAVLIDGTITGRPVPTTNFTYAAFSTGILVNLWDFAQGYFMAQIPFYRDFNGNLQLDISYIGGLTKYFATPPLFSGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4C4</accession>
    <name>A0A1W1I4C4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Acriflavine resistance protein acrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1705"/>
    <dbReference type="EnsemblBacteria" id="SLM47877">
        <property type="protein sequence ID" value="SLM47877"/>
        <property type="gene ID" value="NSJP_1705"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1705"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043602">
        <property type="entry name" value="CusB_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00529">
        <property type="entry name" value="CusB_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="CusB_dom_1" evidence="4">
        <location>
            <begin position="22"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="5">
        <location>
            <begin position="65"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="408" mass="44570" checksum="BD2B3E4380DCA349" modified="2017-06-07" version="1">MNPVRQHPIVTLGVIIFFAVTALVVFRLSSGAKNDPKKTRTITVGTVRPLKQDLDIRLAYTADITPNQVVNIFSRVDGYISKLYVDKGDFVKANHLLVEIDHTDYLHAVNQAKANLAAARAKVTQQDASVRNARLTLDRMRALIKDQFVSQQDLDNAEVNTDAAVAAQESLRAQVQQMEVALAQAETNLAYSYIRAPFSGYIAERNLDLGAYVTGAATSTSTTSRGILSLHDIEVVRTLIEVVEKDVPLIKIGQKAEVRAEAYPDRAFEGTVTRVVQALNRATRTMTVELDLPNKNHLLKGGMFARVEVLVGKHANALQIPIDAVSRLEDAQYVYIVRDGKAERVSVDIGVRDENRVEITKGLIGDEQVIVSGKDLVQSGTPVQAQSLQPAHDDPATPQQAAPAPPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4F8</accession>
    <name>A0A1W1I4F8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0234 protein NSJP_1722</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0234 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1722"/>
    <dbReference type="EnsemblBacteria" id="SLM47894">
        <property type="protein sequence ID" value="SLM47894"/>
        <property type="gene ID" value="NSJP_1722"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1722"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd11740">
        <property type="entry name" value="YajQ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00632">
        <property type="entry name" value="UPF0234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007551">
        <property type="entry name" value="DUF520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035571">
        <property type="entry name" value="UPF0234-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035570">
        <property type="entry name" value="UPF0234_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036183">
        <property type="entry name" value="YajQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30476">
        <property type="entry name" value="PTHR30476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04461">
        <property type="entry name" value="DUF520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89963">
        <property type="entry name" value="SSF89963"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="165" mass="18548" checksum="546EB08F9040F111" modified="2017-06-07" version="1">MADQFSFDIVSEVDMQELKNALDQAVKEIKQRFDFKDSKTEILLKEKEKELVVVSDDEYKLAAVQEIIKAKCVKRGVSLRAFTHGSIEPALSGTVRQISKIQSGLASDKAKEIAKSIKESKLKVQAQIQGEQVRILGKSKDELQGAIAFLRGKDFGIDIRFTNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4I0</accession>
    <name>A0A1W1I4I0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Esterase, beta-lactamase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1746"/>
    <dbReference type="EnsemblBacteria" id="SLM47918">
        <property type="protein sequence ID" value="SLM47918"/>
        <property type="gene ID" value="NSJP_1746"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1746"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="388" mass="41588" checksum="3144F3AD43FCD086" modified="2017-06-07" version="1">MSLPSAIHAELRSAVNDGVFPGAVVAVRLRGQAPCLAAAGRLSSESDSQPVEVSTLYDLASLTKPLVTVTSILLLAQQAGLCLDDPIEKSLPELARSAVGRAPLSDLLAHSSGLPGWRPLYEKLYGDTPVTDPASQGIDPAAARSAVLNLIRDEPAVYVRGTRSLYSDLGFILLGFLIERTTGVLLDEWYRRAVTDPLGAVSLLFAPVSGMGISSDPSAGKAAGIAPTEYDSWRQRLLRGEVHDENAAALGGIAGHAGLFGTAEGVLAVSGAWLDAYHGNDRFFSPDLVRRFVTRQTNVPQSSWALGWDTPSVPSSSGSYFSECSFGHLGYTGTSVWVDPTRKLEVVILSNRVHPSRRNEKIREFRPRLHDLIIREFALFEKGQAGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4I5</accession>
    <name>A0A1W1I4I5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Daunorubicin/doxorubicin resistance ATP-binding protein DrrA</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">drrA</name>
        <name evidence="5" type="ORF">NSJP_1561</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1561"/>
    <dbReference type="EnsemblBacteria" id="SLM47733">
        <property type="protein sequence ID" value="SLM47733"/>
        <property type="gene ID" value="NSJP_1561"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1561"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="323" mass="35285" checksum="A9243B4C4B2E7C17" modified="2017-06-07" version="1">MDRAIAIDVSHLSKSYDGHAAVTDISFQVYTGEIFGLLGPNGAGKSTTLRTLITLLAPTSGSARILGHDSVRDADTVRQLIGYVPQERAIDRFLTGREHLELLAALYHLPKAEAGRRIIELLKLVELESHADRPAKTYSGGMKRKLDIACGLLPNPKILFLDEPTLGLDVQSRLRIWDYIRMLKARGMTVVMTTNYLDEADQLCDRLAIIDGGTIKVIGSPVELKVGLGGDIVSLTLKETDRIQALTSSLKGQPAIRAVNATATGLDIRVESPEKALPAILESANRLGCGLKFIRYNRPRLDDVFIAHTGRRIQEETPNAGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4J7</accession>
    <name>A0A1W1I4J7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpsF</name>
        <name evidence="6" type="ORF">NSJP_1762</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1762"/>
    <dbReference type="EnsemblBacteria" id="SLM47934">
        <property type="protein sequence ID" value="SLM47934"/>
        <property type="gene ID" value="NSJP_1762"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1762"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="115" mass="13403" checksum="181C3F779A35F878" modified="2017-06-07" version="1">MELYESLFIIRPSVTDEETNALIEKMKAVADKTGVQFIKAENWGRKKLAYEVRRERKGTYVYFYFKAPNNTVAELERAYRLEDNIIKFLTVHLEKELVPRRAAEAPSEEFAGGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4P4</accession>
    <name>A0A1W1I4P4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">ftsZ</name>
        <name evidence="8" type="ORF">NSJP_1739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1739"/>
    <dbReference type="EnsemblBacteria" id="SLM47911">
        <property type="protein sequence ID" value="SLM47911"/>
        <property type="gene ID" value="NSJP_1739"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1739"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 5 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="6">
        <location>
            <begin position="13"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="7">
        <location>
            <begin position="207"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="21"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="392" mass="41704" checksum="485AE464B1D3BAE9" modified="2017-06-07" version="1">MFSFQEDVLSPVRIKVIGVGGAGCNAVNTMIASGLARVDFIAANTDLQALDRSRAAYKVQLGPERTRGLGAGAKPEIGKESALESKDQVRECLEGADMVFVTAGMGGGTGTGAAPIVASIARELGILTVGVVTKPFQYEGHRRMLHADEGLRDLRRHVDTLLVIPNQRLLGIVDKTTPLLEAFKVADDVLRQAIQGIADVITTTGHVNVDFADVRTIMSHTGRAVMGMGVSRGTNRAIEAAQKAICSPLLEEGSVEGARGVLLNITGGPNMSLHEIEEAASIIQQTADQEANIIVGQVINPDMGDDLVVTVIATGFEREEQPATVPVGAARASRTTPQAMNGVGIAVADRHHKDIDRPTFLRRSELVQSVDRAALPGEDEWDVPTFLRKQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4S6</accession>
    <name>A0A1W1I4S6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="3">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fabD</name>
        <name evidence="6" type="ORF">NSJP_1769</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fabD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1769"/>
    <dbReference type="EnsemblBacteria" id="SLM47941">
        <property type="protein sequence ID" value="SLM47941"/>
        <property type="gene ID" value="NSJP_1769"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1769"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="5">
        <location>
            <begin position="8"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="311" mass="31954" checksum="3AB8BFF263036C9E" modified="2017-06-07" version="1">MTAGIGLIFPGQGSQSVGMGKALYEAQPALKQVYDEASSVLGYDVAALCFEGPAERLNLTEYTQPALLVSSIAALRALEPAAIKPVAVAGHSLGEYSALVAAGGLSFGDAVRIVQKRGRYMSEAVTPGTGSVAALLGLSADAVSDVCREAASAGVVQAANFNSPGQVVIAGQKAAVERAIEIAKTKGCKKAIPLPVSVPVHTPLMQSAADRLAKDLAAVSWSDLEVPVITNAEAKSLKRAAEIAPSLVRQLPSSVLWEDSVRTMAAMGVTTFVEVGPGAVLTGLIKRIVPEVATMNVNDPKSLEAAIAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I500</accession>
    <name>A0A1W1I500_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48076">
        <property type="protein sequence ID" value="SLM48076"/>
        <property type="gene ID" value="NSJP_1904"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1904"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="68" mass="8114" checksum="C92C4684872B3819" modified="2017-06-07" version="1">MHHNVDDVKQTHSGQWRGLREKLAFLRANQIPNTATMIEPWVNANDEEFRSLCLWFTQLFKEMRGQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I536</accession>
    <name>A0A1W1I536_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="3">2.3.1.180</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">fabH</name>
        <name evidence="12" type="ORF">NSJP_1827</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1827"/>
    <dbReference type="EnsemblBacteria" id="SLM47999">
        <property type="protein sequence ID" value="SLM47999"/>
        <property type="gene ID" value="NSJP_1827"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1827"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="11">
        <location>
            <begin position="140"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="10">
        <location>
            <begin position="274"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM47999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="363" mass="38037" checksum="F6401F98BF2D1DED" modified="2017-06-07" version="1">MVNCNEVRRVDPLGNGPYNPAAYAMSSRQPRHVMIHARIVGTGSYLPERVVSNAEVAGTLGIDPSTVTRLTGIAERRWADPSQASSDLAVEACRRAMDAAGIAPSSVEAIVLSTTSPDMAFPSTACLLQRKLGCPGGPAFDLSASCSGFLYALSMADAMVRSGQVTQCLVVATEIKSRTLDPNDADTALLFGDGAGAVVVRAEQAGAQPNGGILGLRIHAEGAGHDLIRIPMGGSRTPATEATFSRPGTTLRMRGGPLFRLAVKKLNQAIRDLLKEFGVTLDDVAHLVLHQANGRILSSLAAKLGLPVSKLCSVIERAGNTSSASVPVALDYAVRSGRIRQQDLVVLGSFGGGITWATGLIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I556</accession>
    <name>A0A1W1I556_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48130">
        <property type="protein sequence ID" value="SLM48130"/>
        <property type="gene ID" value="NSJP_1958"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1958"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012619214" evidence="2">
        <location>
            <begin position="24"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="164" mass="17693" checksum="2598D71BFEB16543" modified="2017-06-07" version="1">MNPYRCLVACAFVLSSVATSVSAQDAILPQGDPRLNPDERAQEAIRDSRMKQQGQGPNYRVEGELQGGQRQETTGDPNGLARQDTGLSDPSVNPGQATDMEMVQGTVKQANPKMIVVENQNGRTTTLFVDGTTAGDRDVRPGDVITGRMTKQGLAIAIHKEMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I591</accession>
    <name>A0A1W1I591_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate:ferredoxin oxidoreductase alpha subunit</fullName>
            <ecNumber evidence="3">1.2.7.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">porA</name>
        <name evidence="3" type="ORF">NSJP_1994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.1" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1994"/>
    <dbReference type="EnsemblBacteria" id="SLM48166">
        <property type="protein sequence ID" value="SLM48166"/>
        <property type="gene ID" value="NSJP_1994"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1994"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="1">
        <location>
            <begin position="44"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="2">
        <location>
            <begin position="287"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="403" mass="44702" checksum="FE68DC5904621A9B" modified="2017-06-07" version="1">MAESKSFIGTQNKKGQTFTDPWKMLHEAPRTPSFYTGSEVIKEAVRRSSCDVMIAYPITPQSEAAALIGELFAEGYIGDYFRGESEFAVMSQCAGAAFGGARVFTTTAGPGTMRAMENFPMWAGARLPIQMIVTCRGINSPLSIQPDTLEIAYLLNTGMLVWHAETAQDFFDWILKGFMVSEEPDVHLPLALCCDGFFVTHTKDVVNLTPTDMCLPPYDPYRSPVPCMDMECPPVRMMRDPFVMKSNYISYATHASWQQEIWAAIERSRKHSIHWLNGLIDTENTDADIVIVASGTAVSQGREAIRLLEDEGVRCGLVKIKTLRPWPEEEIREATKNAKHIFVPEFNVTGWLAKELRASIPNPQRVHAGPHVCGGMTMPPEIIVSEIKTALGMKSFSLAGRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5B2</accession>
    <name>A0A1W1I5B2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2020"/>
    <dbReference type="EnsemblBacteria" id="SLM48192">
        <property type="protein sequence ID" value="SLM48192"/>
        <property type="gene ID" value="NSJP_2020"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2020"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="403" mass="41515" checksum="54ACD7F3EFC322D5" modified="2017-06-07" version="1">MMPRELTRKAGAINTVAGTGDGAMSGDGGSAVSACLNEPKSVAFDTRGNLIIVDSENHVIRKVDRLSGVIVTVAGYTEPFQRREDPVQPEGGSIPMEEDPLAEQTSGAQAFAHQTDLSGTVRYVINGGGPSMRFGGDGGPAIKALLNFPTAAAVDADGHLYIADTMNHRIRRVDAASGRITTIAGVGQPRFNGDGGPAEAAGLNEPSALAITASSILYVADQNNNRVRAIDLHTGLIRTVAGTGAATYNGDGIPAIEAALAGPSGLAVGADGTLFIADTFNGRIRSVDPDTGMIQTVVGDGGAYRYQGPAEPASSSLARPYGIALSADGQLFISDSDNHLIRRWNPATGRLDRLAGVGVSAYGGDGGLALDASLNYPFGIAMAADGGLFIADTFNHRIREIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5F7</accession>
    <name>A0A1W1I5F7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48242">
        <property type="protein sequence ID" value="SLM48242"/>
        <property type="gene ID" value="NSJP_2070"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2070"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="57" mass="6697" checksum="7ABB356A3FAD1233" modified="2017-06-07" version="1">MNGQRHERCTHSRSAWFHQAEGGKSSAKSHMDQLRWSGLLSRRTEDKKECRSRRLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5I4</accession>
    <name>A0A1W1I5I4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">lspA</name>
        <name evidence="9" type="ORF">NSJP_2084</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the peptidase A8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2084"/>
    <dbReference type="EnsemblBacteria" id="SLM48256">
        <property type="protein sequence ID" value="SLM48256"/>
        <property type="gene ID" value="NSJP_2084"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2084"/>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00855">
        <property type="entry name" value="SPASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="177" mass="19263" checksum="7C0676D1D10A5118" modified="2017-06-07" version="1">MSPTALRYGGLTLLGILIVLVDQVTKQWVMQSMRLHESIVVVPNLFSITYIRNPGAAFGLLAGSSNAFRMVFFGVTSLFALGLLGTILARLPEKDWIGQVSIAAILGGAIGNLIDRLRFGEVIDFLDVYVDMYHWPAFNVADSAISVGVVCLIVHFAFERKETPLPEPDPPPTSLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5I7</accession>
    <name>A0A1W1I5I7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1921"/>
    <dbReference type="EnsemblBacteria" id="SLM48093">
        <property type="protein sequence ID" value="SLM48093"/>
        <property type="gene ID" value="NSJP_1921"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1921"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="337" mass="38150" checksum="F425E00EB9FCA379" modified="2017-06-07" version="1">MRSIVKAKRKRKRTFHTRLTQVDPTSTIIVHGTWANDEDWWRWGAEFPAYLDQHTNDVYKGADFFSWSGGVSHKDRTEGGKALQRWVVAHPTEKLRIVAHSHGGNVAFLASHDGLKIHTLILLGTPIRTDYSPSMKNIRYIYNVYSPDDGWQTAGAEPYPRGEGKTKGQILPEASDNLKVGGSHFDLHTSSLWKNYKLERIIGTLSTMSTDQELVLRQELLILRLREGDRQERLEAILDLARMMSTNAAPVLRERLENDEPSIQIYAAYALHRIAGDKRGVPILLYYLQGPNKDLREGAVYALGLMGKGILPDLRAALAKAPHSASIRRIMHEVRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5M4</accession>
    <name>A0A1W1I5M4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2146"/>
    <dbReference type="EnsemblBacteria" id="SLM48318">
        <property type="protein sequence ID" value="SLM48318"/>
        <property type="gene ID" value="NSJP_2146"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2146"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021796">
        <property type="entry name" value="DUF3365"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11845">
        <property type="entry name" value="DUF3365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="201" mass="22345" checksum="B27F81F0F6B77783" modified="2017-06-07" version="1">MSDNKPLLWVLGGGAFAFVAVTAYWIFALTLANHMKSDLVPPDKASSYIHALIEANRKNYTENVVNKLHAAGIAEAIEHWKDERGVPLPAQFLLETGRLVAQKDLKFSFRLASLTPIYAWNGANTDFERRGLDAVAKDPEKPFQGFVKLEGGRFYQSIYPDYAVNQSCVTCHNQHPNSPRRDFKVGDVMGGIIITLPIDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Q6</accession>
    <name>A0A1W1I5Q6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48315">
        <property type="protein sequence ID" value="SLM48315"/>
        <property type="gene ID" value="NSJP_2143"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2143"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="226" mass="23983" checksum="111951378B78F518" modified="2017-06-07" version="1">MDTPAIGELLTHDEKKAAEAAFARRPFNPKWSAKARAVYDGLVKALPPTADTTDDLIHDPVSATDSGALHHAPDAGSESSEPDPSQHHESSPKLEASVLPGGIPFAQALETGALIDVTPAAKQLGFSFSVNLTRTLWNTGIAPNEAMPQEEQAARLRDVLMALRLRLATHATISPLIDFPALLTIPPNTVPQPVPLFALLQANGDDGTMVTVLLPNEVSTSIIPMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5T3</accession>
    <name>A0A1W1I5T3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48301">
        <property type="protein sequence ID" value="SLM48301"/>
        <property type="gene ID" value="NSJP_2129"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2129"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012438742" evidence="1">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="151" mass="16994" checksum="3905DFA97F23A0B2" modified="2017-06-07" version="1">MRCRARAAVILLAWSHLVACNSDIPEVAVAEVPSLGFMLTVTRTATHPFLARYNLSMKATAADGCSATSELFPDTGGVSRRNVYAGGTGRLYVIGQYDVRVFDKDRCSVELREFRSLEDRLDYLGTFDLDRERRWKFVPATARPEQPFEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I653</accession>
    <name>A0A1W1I653_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48421">
        <property type="protein sequence ID" value="SLM48421"/>
        <property type="gene ID" value="NSJP_2249"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2249"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="66" mass="7609" checksum="52E17CD8ACFCDB67" modified="2017-06-07" version="1">MNLHTRVSGNRNIKVRGLSLRHLTERDTERVEEAMNCNDTETMLAVVDDLISKAVRRATTRFKKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I675</accession>
    <name>A0A1W1I675_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">rplK</name>
        <name evidence="11" type="ORF">NSJP_2328</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6 8">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2328"/>
    <dbReference type="EnsemblBacteria" id="SLM48500">
        <property type="protein sequence ID" value="SLM48500"/>
        <property type="gene ID" value="NSJP_2328"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2328"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="10">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="9">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="141" mass="15006" checksum="E3B6B8D33F876286" modified="2017-06-07" version="1">MAKEISAQIKLQIPAGKANPAPPVGPSLGQHGVNIMEFCKQFNAKTQKEGDSIIPVVITVYKDRTFTFIMKTPPASDLLKKAAGIIKGSGVPQKDKVGKITRKQLNEIAQKKLADLNAADLEGAVKIIEGTARSMGVVIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6G9</accession>
    <name>A0A1W1I6G9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48590">
        <property type="protein sequence ID" value="SLM48590"/>
        <property type="gene ID" value="NSJP_2418"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2418"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="351" mass="39426" checksum="B65317339CFD8812" modified="2017-06-07" version="1">MKLPRKQAAVVRDAIERWKRDGIIPESQAATLTGTIEVQYFDWRKLAKYSFWIALFSIITSVSAALSDRMLQELFEILFNAPAMLKCACLALAATALYRLGLAKRLQDPEKVYRNEAIFFLGVLATAGAVTQLGVAFDTGSGHYSLLLLLSFILYAVLGVMLESNLIWVFGLAALGGWMGTETGYMSGWGAYYLGMNYPLRFVLFGGLLTGCALASERHPIASRFYRSTLVMGLLYLFIALWILSIFGNHGDMASWERVKQIELFHWSILFGAVAGWAVYYGLRHDDDVTKGFGLTFLGINLYTRYFEFFWDGLHKALFFALLAASFWYIGSKAETIWNLGKEDRSDQAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6I9</accession>
    <name>A0A1W1I6I9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Response regulator, CheY-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2432"/>
    <dbReference type="EnsemblBacteria" id="SLM48604">
        <property type="protein sequence ID" value="SLM48604"/>
        <property type="gene ID" value="NSJP_2432"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2432"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="215" mass="23659" checksum="F51C1094EFE71796" modified="2017-06-07" version="1">MSILIVDDFEEQRELLAFTLKQAGYRSLLFADSASDALQRLGIGSSAPPTDHVDIVLMDIVMPDMDGLEACRRIRGDERLEHLPVIVVTAKTDSSDLTAAYTAGATDYIRKPVIPAELVARVSMAMSVKEELDNRTEREKELDEQAKQLGKTVQELKSLRGTLCLCAKCKRVKTGGGIWQRLEDYLEEKLQAKITSGVCNKCGTPGAPNTVRASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6K6</accession>
    <name>A0A1W1I6K6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2458"/>
    <dbReference type="EnsemblBacteria" id="SLM48630">
        <property type="protein sequence ID" value="SLM48630"/>
        <property type="gene ID" value="NSJP_2458"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2458"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039498">
        <property type="entry name" value="NTP_transf_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14907">
        <property type="entry name" value="NTP_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="430" mass="49068" checksum="6159E209311E96F8" modified="2017-06-07" version="1">MQESSEQLVTPLAPILGFKRTPTSSWFPEARFILLCARTSLSDAVRQRVRETALELLDWSLVLDLARFHGVGPLLWRSISATCADLVPPAALTALRQVTQAGTLLNGALVRETVRISRAFEERGLPAIPFKGAALAAVAYKDANLRDFDDLDFIVPQARLAEAQDILTAHGYRPLSQSRESFQAAHYHEPYHLYVHETSRLLVDLQWVMAHEQFSFRLDRPDIWDRRMSLSVEGGRISTIAPEELLIILCVHGSKHAWERLKWVVDVAALIRAQSPDWDRVLSTANRWKCRRMVLLGLRQAQQMMNAELPPAIWTAIRADADVLDLAARMPKSLLFNQQDGIDEHDGPALYYALKDTILEQWRYALELCRDEHRVVYDAPEWLRHRRFLRQLARAIQPVRSWIVKLPLAKQARRGMARLTGRVGTADLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6R5</accession>
    <name>A0A1W1I6R5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease III</fullName>
            <ecNumber evidence="3">3.1.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xthA</name>
        <name evidence="3" type="ORF">NSJP_2539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2539"/>
    <dbReference type="EnsemblBacteria" id="SLM48706">
        <property type="protein sequence ID" value="SLM48706"/>
        <property type="gene ID" value="NSJP_2539"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2539"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09086">
        <property type="entry name" value="ExoIII-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037493">
        <property type="entry name" value="ExoIII-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250">
        <property type="entry name" value="PTHR43250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="290" mass="32424" checksum="056C7E0948698CEC" modified="2017-06-07" version="1">MRIATWNVNSLKARLEKVLWWLERAKPDVLLMQETKLADADAPVEPFRQAGYELVHHGEGRWNGVAIASRCGIGGVITNFGEPLRPARTSDRGDDEPQAEARMIAAECGGVRIISVYVPNGRLVGSPFYEAKLVWFDRLARWIDETVTPDTPAVIGGDFNVAPEDIDVWDPGACHGGTHVSERERQAFARLLDAGFVDAYRLHHAESGRYTWWDYRAGNFHKNVGMRIDHLLVTVPLKQRIVWTEIDREARKGKPVPSDHAPVVIDIDSPGQPFDAGWASAESRIASRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I737</accession>
    <name>A0A1W1I737_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Regulator protein, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2675"/>
    <dbReference type="EnsemblBacteria" id="SLM48842">
        <property type="protein sequence ID" value="SLM48842"/>
        <property type="gene ID" value="NSJP_2675"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2675"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="78" mass="8626" checksum="DE4E6C246A88DD24" modified="2017-06-07" version="1">MATKAYILIKVKAGRTKDVLQSLKRLTGVEQAHSCFGQPDIFVFISVNDERALSDVVITKIHQIDGVEETDTHIVADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I775</accession>
    <name>A0A1W1I775_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_2683</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2683"/>
    <dbReference type="EnsemblBacteria" id="SLM48850">
        <property type="protein sequence ID" value="SLM48850"/>
        <property type="gene ID" value="NSJP_2683"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2683"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="204"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="264"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="490" mass="54631" checksum="D2DEB492D7EF85C9" modified="2017-06-07" version="1">MRLSIFWRIVLTSLLIIVVMGGVNLYALFQLRQLSALSTSMAVQHYPAIESAKRLLTLAYVQLNSEKKYLAVRDDTFLKHFDEEVEEFRRGMTGLAAQEVSPEGLQLLEHVQRLQQERLGMLNVELEQPVQGKGGASPDYEGRRDLVMDQMTTTLQHYVDFHESGISAGVRRSLESSAQAEAVTEQLVLLALLFGIGLAGIASYTILQPLRQLQSHIKQIGQGNFRESLNIRAPSELRSLVDTVNWMGGKLQELDDMKGEFLAHVSHELRTPMASIQEGTHLLLDEIPGPLQPEQRTTLRIMADSSRRLIHLISTILDLSKMDAGMMEYRIVSSDLRRIADISVNKIRLLADAKHVQLVVESPAQRVWVKADAIRIEQVLDNLLSNALKFSPEGGIVKIHMRPDMKAGVLEVSVSDVGPGVPPDELPHIFERFYQGRQKGRQTLPGSGLGLALAKKVVEAHGGRIWIESELKKGTTVRFILRLTKRGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7C3</accession>
    <name>A0A1W1I7C3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2727"/>
    <dbReference type="EnsemblBacteria" id="SLM48894">
        <property type="protein sequence ID" value="SLM48894"/>
        <property type="gene ID" value="NSJP_2727"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2727"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007690">
        <property type="entry name" value="T2SS_GspM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04612">
        <property type="entry name" value="T2SSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="183" mass="20802" checksum="F41BDD761EEDA87F" modified="2017-06-07" version="1">MMMQVLKERWRHLAPRERMILSIGGAVVLGCVLFLALIDPLLTKMDTLERKTLRKQKERSELTLLAAEYAAKQARLAQREQRLPPAESNFSLLAFMEEAATSAQLRDRIVGMQPQQPTTVQGYQETAVDLRLDGVELPQLLALLVVLEQAPYDVQVRHIQIKPKYDNPVNLDASLRIVTYVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7J0</accession>
    <name>A0A1W1I7J0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Beta-lactamase</fullName>
            <ecNumber evidence="1">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.2.6" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48970">
        <property type="protein sequence ID" value="SLM48970"/>
        <property type="gene ID" value="NSJP_2803"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2803"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="416" mass="46522" checksum="769437C7E4B535B2" modified="2017-06-07" version="1">MNIVFLTIVLIVLGAQVTFAGFADDRKVCEYQVLPRLQTNRLLESATAPGDQYCLAIFNWIGPLAQKNYPVSAQWLQKASNQNHPAAQAMLGFFFQMGHGVTQNYAEAMKWYRKAADQGNLDAMTAIGKLYEQGNGVGKDVNEAVKWYRMAADRGDPTARNNLQALAQPRSVQAVSPGEHYFQEGKRLYLANDYAAAAKPFFKAAEMGHVLAQLQIGSQYEFGEGLPKNYGEAVKWYAKAADQGNAVSQKNLGQMYEDGTGVTENWLEAAKWYRKSADQNYDKGQNALGRAYQFGIGVPQSRREAIEWYKRAAAQGNSQADYFAKHLSYQGTSIGFRNEAEHAQVIAGKLRFSLELLDEPVGVTFRNSSERLAYLTKLRGRVDQNEAKTMWNIKKKEYDDCLRAKRSPCFDPGPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7V5</accession>
    <name>A0A1W1I7V5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ysc84 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2907"/>
    <dbReference type="EnsemblBacteria" id="SLM49074">
        <property type="protein sequence ID" value="SLM49074"/>
        <property type="gene ID" value="NSJP_2907"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2907"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84" evidence="1">
        <location>
            <begin position="107"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="194" mass="20836" checksum="84F96541F966BEA6" modified="2017-06-07" version="1">MTMTTQFSERLRGIRLVVVLALPLLFLTGSLASPAWAASARELDARVADTLERFEKEVPGGKGLLESSQGVLAFPRVLKGGAGFGGEYGEGALRIGDNTVDYYNMFQGSFGLQLGGEIKTVVIIFLQEEALKRFRESEGWKAGVDGSVSLVTLGAGGAIDTHNLKDPIVGFVLGQKGLMYNLSFEGTKFTKLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7X7</accession>
    <name>A0A1W1I7X7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49117">
        <property type="protein sequence ID" value="SLM49117"/>
        <property type="gene ID" value="NSJP_2950"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2950"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="74" mass="7990" checksum="C6D3564BBF8B3836" modified="2017-06-07" version="1">MLPVTDRRSPVNEPPVRPSPVDKAKVEVINTAVRSLIRLIKTLSLHGGVHGSPGATSTTADPQAPIRKFRVLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Y2</accession>
    <name>A0A1W1I7Y2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chlorite dismutase</fullName>
            <ecNumber evidence="4">1.13.11.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cld</name>
        <name evidence="4" type="ORF">NSJP_2949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.13.11.49" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2949"/>
    <dbReference type="EnsemblBacteria" id="SLM49116">
        <property type="protein sequence ID" value="SLM49116"/>
        <property type="gene ID" value="NSJP_2949"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2949"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050587">
        <property type="term" value="F:chlorite O2-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010644">
        <property type="entry name" value="ChdC/CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36843">
        <property type="entry name" value="PTHR36843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06778">
        <property type="entry name" value="Chlor_dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="240" mass="27900" checksum="7C9103F0E50C4B74" modified="2017-06-07" version="1">MAAPEQQAPQQTPKRQFVNFVFYKIDPAWRRLPEDERTKGKQEFLRAVEDYTGKVLVIAYSAVGIRGDCDIMLWRISYELELFQEMSTKIMASGLGKYLSTPYSYLSMTKRSIYVDNHTHEGQESKRLTVVPGKSKYIFVYPFLKTREWFLLTKAARQGMMDEHIEVGHRFPSVKLNTTYSFGLDDQEWVVAFESDKPEDFLDLVMALRETEGSRYTLRDTPIFTCIRRSLKETLDTLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Y8</accession>
    <name>A0A1W1I7Y8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase, subfamily IA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2975"/>
    <dbReference type="EnsemblBacteria" id="SLM49142">
        <property type="protein sequence ID" value="SLM49142"/>
        <property type="gene ID" value="NSJP_2975"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2975"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011949">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02252">
        <property type="entry name" value="DREG-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="239" mass="26969" checksum="24E16065AFE420AF" modified="2017-06-07" version="1">MSTQVRVVFFDAADTLFHVNGAVEEIYLRHAVEFGFRETGESLAAIKQAFGRAFREAPPPVFAAADPAQIKQSERLWWFDIVHSVFYRVGIFERFDDFFDRVFEVFEDPACWKLFPETRTTLDRLRSQGVELGIISNFDSRLFAVLRGLDIAQAFDTVTISSLARAAKPSARIFQLAIDKHAVDPDEALHVGDSLRDDAEGAAKAGLKSLLLDRRDRHRGVHVPTIRTLDEVLAYLADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I805</accession>
    <name>A0A1W1I805_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_3011</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49178">
        <property type="protein sequence ID" value="SLM49178"/>
        <property type="gene ID" value="NSJP_3011"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3011"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="29"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="132"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="193" mass="22012" checksum="6B143023489BD4F1" modified="2017-06-07" version="1">MDTTHDREDSDSDLLGAVVAGEQTAFERLYRLYEKRLYQYVYTLVNDQTVAEDVVGETMMAIWRGAGTFSGTSRLSTWIFGIARHKSLDALRRTGRRQREVDLDSAADLPSSCDGPLEGIHRKQVESLTKQALATLSREHQEVLRLVFYEELPYHEIATLLSIPSNTVKTRVFYAKQHLKRALDRLNQKAPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I896</accession>
    <name>A0A1W1I896_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49224">
        <property type="protein sequence ID" value="SLM49224"/>
        <property type="gene ID" value="NSJP_3057"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3057"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="103" mass="11394" checksum="5BC6CE92B72F2832" modified="2017-06-07" version="1">MPNLQVVEPSVEQAVEQAVKKGRMSEEPSRSPSGTTGAIGTVIRWTVGIVVAFALGSWLVWLTAYLQRHFVLEDIRSSCQRIMPDAVERCVDTVIIQRGGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8H8</accession>
    <name>A0A1W1I8H8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 20">Methionine synthase</fullName>
            <ecNumber evidence="6 20">2.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19 20">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">metH</name>
        <name evidence="30" type="ORF">NSJP_3133</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18 20">Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:11172"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.1.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 20 23">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 20 22">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 20">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="20">Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="6 20"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3133"/>
    <dbReference type="EnsemblBacteria" id="SLM49300">
        <property type="protein sequence ID" value="SLM49300"/>
        <property type="gene ID" value="NSJP_3133"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3133"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02069">
        <property type="entry name" value="methionine_synthase_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033706">
        <property type="entry name" value="Met_synthase_B12-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011822">
        <property type="entry name" value="MetH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000381">
        <property type="entry name" value="MetH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02082">
        <property type="entry name" value="metH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 20 22" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="17 20 21" id="KW-0170">Cobalt</keyword>
    <keyword evidence="13 20 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 20" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8 20 24" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 20 22" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11 20 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="15 20 21" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="25">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Pterin-binding" evidence="26">
        <location>
            <begin position="355"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="29">
        <location>
            <begin position="646"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="28">
        <location>
            <begin position="745"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="AdoMet activation" evidence="27">
        <location>
            <begin position="894"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Methylcob(III)alamin binding" evidence="22">
        <location>
            <begin position="755"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="22">
        <location>
            <begin position="1187"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="690"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="21">
        <location>
            <position position="758"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="803"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="807"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="859"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="944"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR000381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="SLM49300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1225" mass="134940" checksum="C1FB2A7FA740079E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8I8</accession>
    <name>A0A1W1I8I8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49324">
        <property type="protein sequence ID" value="SLM49324"/>
        <property type="gene ID" value="NSJP_3157"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3157"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="445" mass="45977" checksum="10F93D12FDB7B0B9" modified="2017-06-07" version="1">MKGDRHDMDRSGDRRAVSLRLPADPPVHDRHRSGAIVALSLYLLLIGVMAWVWAVTPAFALVSATGYVRVATDSSKLLYLGANRAALLSTVAQAAAVTSPASVAVRLVTGPIGWAALGVSVGLALYQMHYSDTELQAVKQAAAPSNLQTGTGLVLPNGAALETAQSCLYPSCTAGQAQIVTVAIPGKTQATCGLNVQPVAFPLAWFSNLGEAWNSGRNSCVQTFRYVYDGASSNNLVRSGVGVATPQQIQDYVAALPASDPKSIESNTTPLGQGATATPAATTTSTAVSPTEIPTTVKPVGQVAPTDAVVDPNAPKPAGTQTVPATQNTTSTTTTTTNPDGSTTEATQESASVSCSGADHDARSFGSILQAHITTWQGSGLLSALAILQTLTWPDALPIITFTSATWGTHQVDFNQWAAVFTVLRTLTIAGAGFAAYRIIFVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8J2</accession>
    <name>A0A1W1I8J2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49310">
        <property type="protein sequence ID" value="SLM49310"/>
        <property type="gene ID" value="NSJP_3143"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3143"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012303285" evidence="2">
        <location>
            <begin position="27"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="220" mass="23422" checksum="6BE07FE9714BF576" modified="2017-06-07" version="1">MQRTWINYSRWLFGMVLLFGTSAAQAAEGTAKGETSDEKGQQGLGLGPHGQSSNVVMSGPDMVIGKITKIQGEQFTVHGDRGQDISLKVTKDTNKICAGGKGPAKTSSGQESSKEKQEIPPTAFMEQHAAKGRVLSEQEMMQQLHESGTQDEVGALSKDPSKLKDTVGTTDPKAKEDTAKGSGFMVGGQDCNFKVGDKVRVEASDMGTVTTIKQLARATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8S5</accession>
    <name>A0A1W1I8S5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49417">
        <property type="protein sequence ID" value="SLM49417"/>
        <property type="gene ID" value="NSJP_3250"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3250"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="18"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="184" mass="20267" checksum="E2437D5FF2005D5E" modified="2017-06-07" version="1">MDQQQNGQANGAPLPLYVTLILDETGSMQSCKGSAIAGINQYLASLREEEAETRFTLTLFNSKKTEVRHNAVPVRQVNDLDVETYRPDATTPLYDAIGRTLSAAKQEAPNDAKKLCVILTDGLENASQEYTRPQIFDMIKSFEQGGWRFLYLGADHDVWAAGESLGIAGDGRVCFSKLEVAETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8V0</accession>
    <name>A0A1W1I8V0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49299">
        <property type="protein sequence ID" value="SLM49299"/>
        <property type="gene ID" value="NSJP_3132"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3132"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010736240" evidence="2">
        <location>
            <begin position="30"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="263" mass="30004" checksum="7D7F04CE71796C3D" modified="2017-06-07" version="1">MLQHRMYACLPRLLLSFALALGVCAPTRAAASAYFEDGFLGLTQIELHEKLGMPQAVRDRKSALRVFTYYAIADWEKYFRKLVSPENGEDVYMFKRDGIEVRYSFSYAVDPNDHSENRALYVRLVDVEFTPPVPIAQVPALIPEFHPSDDPAAPSFRSNIWLLLFKGAPSPQARFIVKEAAKDQLDWTLAYQLFSLQGLPDPLTIKSPVDRLEIGTQSIELVKRRQRHTHDPVMNPYSKEFLQQPAPPRQTQAKKIPVPQYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Y2</accession>
    <name>A0A1W1I8Y2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49474">
        <property type="protein sequence ID" value="SLM49474"/>
        <property type="gene ID" value="NSJP_3307"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3307"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="55" mass="6268" checksum="1B9004D2155D2BA7" modified="2017-06-07" version="1">MNGLIYQERSGPHRCLPALLARFKGYENCVVIEYTWSTRICRVNAGSYRISDAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I935</accession>
    <name>A0A1W1I935_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylsulfatase A family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49505">
        <property type="protein sequence ID" value="SLM49505"/>
        <property type="gene ID" value="NSJP_3338"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3338"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="32"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="504" mass="55146" checksum="59CCFC3749CD7CA6" modified="2017-06-07" version="1">MDRIVQKMLIYGMVMAAVVEMPVLTQAAERIPNVVFILADNVGYGDMGPYGGGELRGAPTPRTDQLAREGLRLTQFLVEPACTPSRAALMTGQYSIRNGLSLVVIEGSPYTLPGRAVTMGELFKNAGYATAAFGKWHLGGAPHSLPTAHGFDEFYGIPPDISWDSATYVDTIELTHSIPAPRQALLARGPQIVEATAGGPLKHIKPFTQEVRADIDNELVAKSIDFMKRHTDAKKPFFLYLPFSMGHIPNLASGQFKGKSRIGNYGDKLMEGDFHVGQIMDTLKELGVENNTILVFASDNGPSGEAFREFGNNGTPDMGSPGPFRGELGEVTEGSIRTFCFIRWPGHVKPGTTSYAMFSIMDFFPTFAAIIGARVPADRPIDGVDQTDVLLGKSDAGHREHLLSFIGADLVAARWKQWRMYFTDIHPTGQGPQRQPGIFSTSAPLAGYPILYNIEMDPHEDLTAGTFGWVTGPLFKTVQEYLESVKKYPNPPSPNITQFRSETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9H2</accession>
    <name>A0A1W1I9H2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3473"/>
    <dbReference type="EnsemblBacteria" id="SLM49640">
        <property type="protein sequence ID" value="SLM49640"/>
        <property type="gene ID" value="NSJP_3473"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3473"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="779" mass="78692" checksum="DB9368A9D24071DF" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9I4</accession>
    <name>A0A1W1I9I4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3362"/>
    <dbReference type="EnsemblBacteria" id="SLM49529">
        <property type="protein sequence ID" value="SLM49529"/>
        <property type="gene ID" value="NSJP_3362"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3362"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024623">
        <property type="entry name" value="YtxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12732">
        <property type="entry name" value="YtxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="78" mass="8285" checksum="A8F10BD32F4E2FE6" modified="2017-06-07" version="1">MSEQGKQAVKMAAMVAGSAAIGAGLGLLFAPQTGAETRRELNRYAKKAQVQATRWSRAIKSGIQEVADRTKRPVVEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9J7</accession>
    <name>A0A1W1I9J7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Vitamin B12 transporter BtuB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_3550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3550"/>
    <dbReference type="EnsemblBacteria" id="SLM49717">
        <property type="protein sequence ID" value="SLM49717"/>
        <property type="gene ID" value="NSJP_3550"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3550"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012099598" evidence="6">
        <location>
            <begin position="26"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="86"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="244"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="703" mass="77007" checksum="9BDEE6674CB75F6F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Q7</accession>
    <name>A0A1W1I9Q7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49778">
        <property type="protein sequence ID" value="SLM49778"/>
        <property type="gene ID" value="NSJP_3611"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3611"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="412" mass="47144" checksum="2B7848C0350BD02E" modified="2017-06-07" version="1">MATIIPILKAPPVFKNKDYRDVLIRELEGGKIPISLGKTCPVKCEFCYEIDHSYRETLDPPKTTDEDWKFIIDYLNKKPTDPMQFWCLGGNEYMEWTDLFLHPKAMEWVEDFLTSTDKNITFFTVGYVQVPKIHQLAAKYPGRINFELSVITLGDYRQRLMPHAPSVKHLMKVLDGPAVSSANFYSFDVHTMSKDAQAISAVNQKCVLWMGCLTPVKGIKEPTADLMRQGRKYLPDEARRLYDLGLPNVQTIQTEAPITAFMNRKRIVSAFDSLELEKKDTVVMAKSVYKILNMYRKNRARFLMVPNATLGGDSDCSVLLTFDDIARSVTTQKRIHVPKCMMQSGRGLYTDIGGVSPEQFTRKTGVKVSVLHKIDTRFANRLLWRNCLVKNYVEDYVSNPLVQSYENYSITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9U6</accession>
    <name>A0A1W1I9U6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative long-chain fatty acid outer membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_3595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OmpP1/FadL family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49762">
        <property type="protein sequence ID" value="SLM49762"/>
        <property type="gene ID" value="NSJP_3595"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3595"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005017">
        <property type="entry name" value="OMPP1/FadL/TodX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35093">
        <property type="entry name" value="PTHR35093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03349">
        <property type="entry name" value="Toluene_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="488" mass="51311" checksum="DBB12AD50B67B80D" modified="2017-06-07" version="1">MRQAVVEQAGGRPLDRTRYPSGCRRGRVGRWPGAITILACTLLWLCDLAVSSRVASAQVPRIQGQGTAASAMGNAFSAQADDPSAIHYNPAGLTNLHGVEFMGGLLLSGGTTQFTGPTGVTATGDRNGNVAWPPPAHVYLTANVQDLGLTALGPLSAGIGVTSPFGSLMRWPADGPFRSATIFNTLPLLDIKPTVAYGLTRDLSLGAGVDIYTFSKLVGEGQVERQSIWPGGFGIPAGARIELSGADTAAGFNAGLLYTALRNSDGRPLVNIGFVYRSQATLHLSGALLANGTKVSDATATLVLPSVITGAVAFWPYRAASREWKVELNVDRVGWRVVKNLDVHLANGATIPQPLNWQNTYAVMVGTEYKWLALETLPAWDVAVRAGYTNQQTQMPDVSFDPGVPSADVNIVGGGVGFLCRAGGSLFGLIRCGKAGAGSLSMKGIGLDLSYQASLYEPRTIAGNRNPTVNGTYRTTLHTGGLSLRLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA03</accession>
    <name>A0A1W1IA03_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">lspA</name>
        <name evidence="9" type="ORF">NSJP_3710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the peptidase A8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3710"/>
    <dbReference type="EnsemblBacteria" id="SLM49877">
        <property type="protein sequence ID" value="SLM49877"/>
        <property type="gene ID" value="NSJP_3710"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3710"/>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00855">
        <property type="entry name" value="SPASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="163" mass="18118" checksum="B2724922082D5F15" modified="2017-06-07" version="1">MRTLLMLLLLLSCLGCDQVTKKLARTYLAFHPPVSCCHDVVRLHYAENAGAFLGLGWNLSEDMRILIFQIAVGLCLFALFVVLLRSHHHPSSFLVAWTLILSGGIGNVLDRLLHHGRVTDFMNLGIGSLRTGIFNVADVCITVGVVWLLLALRWEDEPRAEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA60</accession>
    <name>A0A1W1IA60_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49880">
        <property type="protein sequence ID" value="SLM49880"/>
        <property type="gene ID" value="NSJP_3713"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3713"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="87" mass="9878" checksum="516F45155A123AE1" modified="2017-06-07" version="1">MALATESVEARIEWCRQQKARAAQPIEREGWHAEAEGLRDALLSEDHSSLYRDCAPTVFERYAMGLQDGRALMLVAVAEQQHAMSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA70</accession>
    <name>A0A1W1IA70_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3723"/>
    <dbReference type="EnsemblBacteria" id="SLM49890">
        <property type="protein sequence ID" value="SLM49890"/>
        <property type="gene ID" value="NSJP_3723"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3723"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="208" mass="23399" checksum="564177A75B057423" modified="2017-06-07" version="1">MPTRKPVSRQLPNAPATQRVVAAARRHFLSQGFRRVTMDELADELGMSKKTLYGLFPSKTALVESVILDKFRCAEADLRRITAASRGDVPGALRRLVAAVQTHTQEIQAPFVRDIQRDAPHLFEVVEQKRRELIRRHFGKLLSEGRRARVIRRDIPMPLIMEILLGTVRAVMNPPKLIELGLTPDQGYSAIMSVIFEGLLAGTSRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAA3</accession>
    <name>A0A1W1IAA3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3810"/>
    <dbReference type="EnsemblBacteria" id="SLM49977">
        <property type="protein sequence ID" value="SLM49977"/>
        <property type="gene ID" value="NSJP_3810"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3810"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="487" mass="55377" checksum="C46BDE012CAD199D" modified="2017-06-07" version="1">MDSGPGMNSVVMIVHDFPPEGNAGVYRPLRFVRQLQKMNWKTTVISAVPGQYERYDPELLKLVPRETEVIRVKGYGAWQALQAWRSRHKRSQNQNPDIPSDQEGTDQGTFPSWIRDAARNLEAWCYHPDMAAPWIERAVRATVSACSGEAVRVIWATAGPVTSFYVAQAASKQTGIPYVLDFRDSWTISYNEFESRRPDWAVRRDRKRMFELLQGSQAVVFRYATEAECYWRAYPMALDYRKVHIIPNGYEGAIEEFVEPDCKRCTILYTGTLTSYRFETLLDALRMLKDTASADACKLRLLFVGEGTEALRSVGDRLGLADLIETRGPVSYSEVARLQREAHAFLVLGRIPTMRGYELLVGAKLFEYLRMGRPIIGVLPSDETTSILRRLKSPIIADVESSEEIVGVLKRVLRAWSTHTLSTLVPDRKICEEFSVERQTVALTKALEGRPADHPFIRGAVDIPKSLQRYFDEERWSEGSARPGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAC5</accession>
    <name>A0A1W1IAC5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Abortive infection phage resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3778"/>
    <dbReference type="EnsemblBacteria" id="SLM49945">
        <property type="protein sequence ID" value="SLM49945"/>
        <property type="gene ID" value="NSJP_3778"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3778"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018891">
        <property type="entry name" value="Abortive_phage_infection"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10592">
        <property type="entry name" value="AIPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="660" mass="75466" checksum="2CEF7A23EEC83FE3" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAK6</accession>
    <name>A0A1W1IAK6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3887"/>
    <dbReference type="EnsemblBacteria" id="SLM50054">
        <property type="protein sequence ID" value="SLM50054"/>
        <property type="gene ID" value="NSJP_3887"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3887"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="105" mass="11710" checksum="EBBB63D8027E88FF" modified="2017-06-07" version="1">MKVVNLSDCQQFSQEKMKKNNIFQTPRFFCDVYCFEPGQEQKGHVHGEQDKVYLVLEGQGTFQVGGEQQVLRSGQGTLAPAGQEHGVKNDSGQRLKVLVFVAPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAK8</accession>
    <name>A0A1W1IAK8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3742</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3742"/>
    <dbReference type="EnsemblBacteria" id="SLM49909">
        <property type="protein sequence ID" value="SLM49909"/>
        <property type="gene ID" value="NSJP_3742"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3742"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="44"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="337" mass="38287" checksum="9A0D693B7CF6EA21" modified="2017-06-07" version="1">MRAMSNPPNPFESRHREYLEPAPTSRLQMFEDATREILSRNDSPDLSFRWSLNPYRGCFHACAYCYARPTHEYWGFGAGTDFESKIVVKREAPALLRRAFDKPSWDGDIIVFSGNTDCYQPAEASFELTRSCLHVCAEYRNPVGIITKGVLVLRDLDVLERLRRDAWVRVYFSIPFADDAVARQIEPHAPSSRKRFEAMAALRDAGISTGISVSPIIPGLNDEDIPELLERAREAGATEAMSTLVRLSGPVEDVFLQRVGEAFPDRKAKIVHRIQEVRSGAMTDGAYFRRHHGTGTYWNMVEQLFALSKRKAGFFPLDHETVPRTFRRPEAAQTVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAN3</accession>
    <name>A0A1W1IAN3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycos_transf_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3804"/>
    <dbReference type="EnsemblBacteria" id="SLM49971">
        <property type="protein sequence ID" value="SLM49971"/>
        <property type="gene ID" value="NSJP_3804"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3804"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="204"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="395" mass="43906" checksum="F65DBB56CF41E1C1" modified="2017-06-07" version="1">MNILVLHSELGVLRGGGENFTRNLFSAFSTRGHRVTAAFVANPSGQYPFSLPPGVTPIPLAGWWSRQFGQAQLLSIGSWIPSTSLLKHQWDRMRGGICWRIHRWHESRFQRRAEHVFANRWAEFDAIYVHGSSKLARLASRFRPTVLRLPGPVSQELAPVLRQVHAVCANGDALVQIRTFLGDHAIEIPLGVDSRTFFPNSRSVRQSLGWAEECSVIGYVGRLIHIKGVDLLATAFREVARVSPHARLLIVGSGEEESAIRAILRCELARGLVHLEPDVPHGRLADWYRAMDLLVMPSRYENFSNAIVEALACGIPFLGSDVGGNKLLAEAGCGHLFEQQSHDSLTSCLRKLMADRATLKLNGAFGVEYVRTHYSWAASAERLEHVLTSRLGVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAV4</accession>
    <name>A0A1W1IAV4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferric uptake regulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fur</name>
        <name evidence="3" type="ORF">NSJP_3948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50115">
        <property type="protein sequence ID" value="SLM50115"/>
        <property type="gene ID" value="NSJP_3948"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3948"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="154" mass="17436" checksum="14A797B0C006ECA9" modified="2017-06-07" version="1">MDIYIPDQEKITMRTMNVAKMSPNRSRLKHSKKRDIILAAFATQNHVTAQKLHNSLAEEGHRISLGTIYRTMRLFCKMGLAQARHCEAKTQYGHTAAKGRHDHLVCTACGNIAEFENQEIERLRKEIAAENGFTLSVHKLELYGLCSLCGHSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB40</accession>
    <name>A0A1W1IB40_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_4045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4045"/>
    <dbReference type="EnsemblBacteria" id="SLM50212">
        <property type="protein sequence ID" value="SLM50212"/>
        <property type="gene ID" value="NSJP_4045"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4045"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="278" mass="32163" checksum="178D8659C86C724D" modified="2017-06-07" version="1">MAGTGFSNSMVVAELRYIQSVREAREFKNPDTWVRRFIPTFRRWQCALLSSRKLADLRSDPFYYYLVARTEYYDRLFLNAIEDNVRFIINVGCGTDTRPYRFNDALEKKGIKVLECDQPVAIAQKEEMSRRQGVFDHVAYMSVNLNDAAWPELESWLSRNRTGKGFVFMEGVSPYVNTDTFDRFLSLLAKELLPGSRVAYDFKLNGVKDDFGRTGRTQHPFRLPAARETISDYHKKFGYRLEHMELGSELSVRLLAGIKQMGAALFEEDALLQLEVMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB48</accession>
    <name>A0A1W1IB48_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_4077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50244">
        <property type="protein sequence ID" value="SLM50244"/>
        <property type="gene ID" value="NSJP_4077"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4077"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="152" mass="17501" checksum="5756703F55DE0429" modified="2017-06-07" version="1">MRYSLYWRRALIICLFGIFAGCSGIPPLAEQEQHIKNNEMPLHQLTPRAFAGVWGVPPYQRVEFMQFFIMKDGSFVPRSRVALGEAPKGWDAGVEAGEALFLVYPDRGWLLVFLDERLVYKEALTAAQLHTLGRDWKMEDRYRSRLESPASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB62</accession>
    <name>A0A1W1IB62_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-antigen export system, ATP-binding protein RfbB (Modular protein)</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rfbB</name>
        <name evidence="6" type="ORF">NSJP_4063</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50230">
        <property type="protein sequence ID" value="SLM50230"/>
        <property type="gene ID" value="NSJP_4063"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4063"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10147">
        <property type="entry name" value="Wzt_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029439">
        <property type="entry name" value="Wzt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="33"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="72"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM50230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="429" mass="47252" checksum="2CA2931A137558B4" modified="2017-06-07" version="1">MGNAAIRAEGLSKQYRIGSTRRRHDRLIDALAYRASNLLGIGASSQPDDNLIWALKDVTFEINKGDSVGIIGRNGSGKSTLLKILSRITEPSSGRAAMEGRFCSLLEVGTGFHPELTGRDNIYLSGAILGMKKREIDRKFDEIVAFSEVERFIDTPVKHYSSGMHVRLGFSVIAHMDPEILIVDEVMAVGDGRFQQKCFDKMAEAGKSGRTVLFVSHDMSAVARLCKKAILLEKGRLINEGPAHQVVGEYLYSAGSITPSKEWVDPESAPGNDTIRFRSLRVRTENEFVKDSVDIGESIGIALEFDVLQPGQVLVPCFLLHTEEGVVVFETYDRDPAWIRRPRPIGRYVSTAWIPGHLLTEGTLIVNCAVITEVPFHDHCHVLDAVAFHVHESGVGTSARGDYAGDILGVIRPLLKWTTYHNPADNGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBD3</accession>
    <name>A0A1W1IBD3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spore coat polysaccharide biosynthesis protein SpsC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">spsC</name>
        <name evidence="4" type="ORF">NSJP_4145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4145"/>
    <dbReference type="EnsemblBacteria" id="SLM50312">
        <property type="protein sequence ID" value="SLM50312"/>
        <property type="gene ID" value="NSJP_4145"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4145"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="381" mass="42207" checksum="068D5921C5E07D0A" modified="2017-06-07" version="1">MTERRQIQIATPSLGEEEWQALREPIETGWLTQGPKVAAFENAFAARHEVKHAVAATSATTGLHLALAALGIGPGDEVIVPAFTWVATANVVLYCGATPVFADVDRVTYNIDPKDVARRLTPKTKAVIPVHLFGLCADMAALRKVLRPDIKIIEDAACAAGASWEGRPAGALGDLGVFSFHPRKSITTGEGGMVTTNDDGLADRVRKLRNHGASVSEEERHHGPRPYLLPEFELLGFNYRMTDLQGAVGLVQLKKLDTFIDERADLAARYRKELAGVRWLRMPEEPPKGRHAWQAFVTYVNPNAAPRSRNEIMEFLQQQGISTRPGTHAVHMLKYYRQRFGLKPDDFPGARDCDRNTMAIPLHNRMSDDDLSYIVQALSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBE3</accession>
    <name>A0A1W1IBE3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_4155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50322">
        <property type="protein sequence ID" value="SLM50322"/>
        <property type="gene ID" value="NSJP_4155"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4155"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="273"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="538" mass="60756" checksum="5BD1D5A34FEEB147" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBJ4</accession>
    <name>A0A1W1IBJ4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">MEP cytidylyltransferase</fullName>
            <shortName evidence="7">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ispD</name>
        <name evidence="8" type="ORF">NSJP_4114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4114"/>
    <dbReference type="EnsemblBacteria" id="SLM50281">
        <property type="protein sequence ID" value="SLM50281"/>
        <property type="gene ID" value="NSJP_4114"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4114"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM50281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="236" mass="25572" checksum="2DBD9170E292A17F" modified="2017-06-07" version="1">MDNRRVVALIPAAGRGLRMGGPVPKQFLALGGFPLIVHSLRTFHSAAVIDAIVLAVPEADVDYCRSEIVRAYGFTKVTEVVAGGKERQDSVRLALSRVGTETEIVVVHDAVRPFVTVGMIDEVVAAARAGGAAIVALPMRDTVKQVGPDRVIERTVDRTPLWLAQTPQAFRRAWLADAHRKAQLEGVQATDDAYLIEWFGRPVSVVEGNGENIKVTRPEDLFIGEAILSSRLSSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBM6</accession>
    <name>A0A1W1IBM6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">General secretion pathway protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gspE</name>
        <name evidence="3" type="ORF">NSJP_4006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4006"/>
    <dbReference type="EnsemblBacteria" id="SLM50173">
        <property type="protein sequence ID" value="SLM50173"/>
        <property type="gene ID" value="NSJP_4006"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4006"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="582" mass="64644" checksum="874B7B2FD96BA57A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZP9</accession>
    <name>A0A1W1HZP9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0042"/>
    <dbReference type="EnsemblBacteria" id="SLM46214">
        <property type="protein sequence ID" value="SLM46214"/>
        <property type="gene ID" value="NSJP_0042"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0042"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="213"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="344" mass="37250" checksum="BDA9D242489D215B" modified="2017-06-07" version="1">MMEQAAVQTERTSTRTFRRMSSFDRTIITGVVLLTSVFPVELFSTAPPPPRGSDGQYSGKQGQVVVVKVPHQEEVTEVKGTILNRTVPFFREYRRGEVPGYVGLIGIDMQDEPGTHELAVVVTKGEEVKHLSYNVLVTKEKFNIEHLTLPKDKVDLDDKAVTRWKAEQEQVKQALVENSASRLWRSSFVEPVSGKRTGIFGSVRVMNGQPRNPHNGEDIGAPLGTEVATTNDGVVRLTVDHFFSGKGIFVDHGLGFYSMYFHLSEVLVKEGDLVKAGQVIGKVGATGRATGPHLHWGVKLNGARVNPYALLDLPFSSAAASGMPPASASSAASPVSAGAISAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZY4</accession>
    <name>A0A1W1HZY4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">secD</name>
        <name evidence="10" type="ORF">NSJP_0122</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0122"/>
    <dbReference type="EnsemblBacteria" id="SLM46294">
        <property type="protein sequence ID" value="SLM46294"/>
        <property type="gene ID" value="NSJP_0122"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0122"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM46294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="547" mass="59647" checksum="AA05B7295566C8FE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I000</accession>
    <name>A0A1W1I000_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46325">
        <property type="protein sequence ID" value="SLM46325"/>
        <property type="gene ID" value="NSJP_0153"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0153"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="71" mass="8133" checksum="B0E3588587812AD1" modified="2017-06-07" version="1">MHCTKCEGLMVPDDLIDMQESSIPMWMKGWRCVSCGNIIDQLIQQHRDLRDSWSKVKSLSPSISRTDKVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I010</accession>
    <name>A0A1W1I010_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_0159</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0159"/>
    <dbReference type="EnsemblBacteria" id="SLM46331">
        <property type="protein sequence ID" value="SLM46331"/>
        <property type="gene ID" value="NSJP_0159"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0159"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="24"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="263" mass="29966" checksum="D79F38CDE928F1C5" modified="2017-06-07" version="1">MKLHRVVALVSRHLYLYRRSLPRIMEIFYWPFLDLVIWGFITLYLAKYQPHVPGFVTFFLGALILWDMLFRSQQGITISFLEELWARNLMNLFASPLTPAEFLAATIAMSIFKVTCVSLVMGVCAWLFYDYNVLVMGLWLFPFVVNLVVTGWSIGVLTTSLIMRFGQEAEVLAWSMVFLFQPISCVFYPLDVLPTWLKAVAWVNPAAHVFEGMRAVLNGTGAPVANLIWACSLNAVMLMGMIVLFYKTFAYCKVQGSLVRIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I020</accession>
    <name>A0A1W1I020_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized amino acid permease YdaO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ydaO</name>
        <name evidence="6" type="ORF">NSJP_0150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0150"/>
    <dbReference type="EnsemblBacteria" id="SLM46322">
        <property type="protein sequence ID" value="SLM46322"/>
        <property type="gene ID" value="NSJP_0150"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0150"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="607" mass="65682" checksum="03B45E8958DE3D24" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I021</accession>
    <name>A0A1W1I021_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_0174</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0174"/>
    <dbReference type="EnsemblBacteria" id="SLM46346">
        <property type="protein sequence ID" value="SLM46346"/>
        <property type="gene ID" value="NSJP_0174"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0174"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012822697" description="Cytochrome c domain-containing protein" evidence="5">
        <location>
            <begin position="25"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="54"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="149" mass="15831" checksum="B299D9F2CC4589F7" modified="2017-06-07" version="1">MGTFSKFLGVSAAVLMLSASVAGAEEKDPLKPRVPADQIAEAKAMKNPVASSPESIAKGKALFEGKGTCFNCHGKEGKGDGPAGAILNPSPRNFTNCKFHKKRKDGELFWVIKNGSPGTGMVSLIPAAITEEEAWTIINYERSFCKGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0N4</accession>
    <name>A0A1W1I0N4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Lytic murein transglycosylase</fullName>
            <ecNumber evidence="4">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0267"/>
    <dbReference type="EnsemblBacteria" id="SLM46439">
        <property type="protein sequence ID" value="SLM46439"/>
        <property type="gene ID" value="NSJP_0267"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0267"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010697868" evidence="2">
        <location>
            <begin position="31"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="404"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="449" mass="49970" checksum="2BD684E1E7DDEA2E" modified="2017-06-07" version="1">MPSLCAIQILSHSLIGLSFLAASWASPVSATTHSDASDIMNAPLPALDGGEGPGDEDELDPNLVPLETETPPSGPAVTEDPSSVPHAEEILEIAPLPNSSASRFADSFNPPVETPQSQASGASELTVYNVPIVMDPSVQSHIRYFNTAIRDRFEQWLLRLSRYQPLVENIFAEFHLPSDLVYLSLVESGFNPYAYSRAKATGPWQFMKGTAKVYGLRVDSYVDERRDPIKSTVAAARYLRDLYDMFGTWPLAMAAYNAGEGKVMRALHKAQAESFSDISKTRLIRRETKEYVPRFMAATIIARDPVRYGFPQSSTEPHQFEEVIVNRPLHFRAIANVTGVPYEELRLLNPELRRDATPPGGENYHLKVPVGFKAKVEQLLERVPNHKFPPLPAKPQFATAKTSLRYKVQGGDTLEKISKRFRIPLKTLKTRNSLTSPVLRPGDFLVISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0N8</accession>
    <name>A0A1W1I0N8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46568">
        <property type="protein sequence ID" value="SLM46568"/>
        <property type="gene ID" value="NSJP_0396"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0396"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="65" mass="7179" checksum="B27F262DB2D6D574" modified="2017-06-07" version="1">MQRLSIQLPAPLKAKLDAEKKRDTSGAELIRHVRTTTAEWSRSTAAWSVGEPSGCNRREEGEPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I119</accession>
    <name>A0A1W1I119_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Hybrid histidine kinase</fullName>
            <ecNumber evidence="6">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_0520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0520"/>
    <dbReference type="EnsemblBacteria" id="SLM46692">
        <property type="protein sequence ID" value="SLM46692"/>
        <property type="gene ID" value="NSJP_0520"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0520"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="256"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="496"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="192"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="612" mass="67028" checksum="C00E5E96F10DA5A0" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I121</accession>
    <name>A0A1W1I121_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0509"/>
    <dbReference type="EnsemblBacteria" id="SLM46681">
        <property type="protein sequence ID" value="SLM46681"/>
        <property type="gene ID" value="NSJP_0509"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0509"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="73"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="127" mass="13654" checksum="69F3FEA8AC920F7C" modified="2017-06-07" version="1">MVTVGQLMKQDLVTVDTGTSVVEAAKLMKACNVGSVLVSQENRIVGIVTESDVVRKFVGVDRVAYFTPVESIMSSPVLGIEARRPITEAADLMNKHRTRHLGVTKAGAIVGVVSVRDFLQPVAVDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1B5</accession>
    <name>A0A1W1I1B5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Zn-dependent peptidase, M16 family</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_0487</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0487"/>
    <dbReference type="EnsemblBacteria" id="SLM46659">
        <property type="protein sequence ID" value="SLM46659"/>
        <property type="gene ID" value="NSJP_0487"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0487"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012754592" evidence="3">
        <location>
            <begin position="29"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="4">
        <location>
            <begin position="42"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="5">
        <location>
            <begin position="196"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="458" mass="51648" checksum="051738EFAFFC0A2C" modified="2017-06-07" version="1">MIVQLSRFLITVLVLAVAAFASARPAQATDPAEFLLSNGMKVLIVEVPKAPVATVQVWYKVGSRNEVMGRAGLSHMLEHMMFKGTNKYPNGSFSRLIRKNGGMDNAFTSQDFTAYFENLAADRVDLALELEADRMQGLILDQNELKTEREVVKEERRLRTEDDPQGALVETLFAQAYMSHPYHWPVIGWFGDLDAMTLEDLQRHYDTYYSPNNATLLVVGDVKADNLLPTIKQLFEPIPRGPEPKAVLTMEGEQRGERRFLLKREAQVPFVMMGFRVPNFSSEDSYALDILESILSRGKSSRLYQSLVYDQKLAIAVGAEYSLLQTDPGLFYFYSLVSPGQKVEQVEEALNREIHRLQNEPPTDQELQRAKNQVEAMHVFEQDSNFRRAMLLGQAESIGAGWKRVDQFLERIAAVTPKDVQRVARQYLIEDTRTVGTLIPVPPKQPDPVPAAAQPGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1C9</accession>
    <name>A0A1W1I1C9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46792">
        <property type="protein sequence ID" value="SLM46792"/>
        <property type="gene ID" value="NSJP_0620"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0620"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025333">
        <property type="entry name" value="DUF4239"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14023">
        <property type="entry name" value="DUF4239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="253" mass="27462" checksum="A6852CB0F3FD607C" modified="2017-06-07" version="1">MSSLAIALIVFLCVFVSGLLGLVIRMCLPSHHLREESMGIVKHGTGLIATLAALVLGLMIASAKASFDTIKSEVGQMAVRVVQLDRVLAHYGPETKETRELLQRVIASAIEVIFSDEGTGQARMDTPERLARIEDIQAKLRDLAPRTDAQRVLQARATELVKELLHMRWLLIVEAESAIPTLFLVVLVFWLAFIFAGFGLLSANNTTVVAIMIVCALSVSGAIFLIGEMDRPLDGLIKVSSAPLRNALAHLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1F4</accession>
    <name>A0A1W1I1F4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rluF</name>
        <name evidence="5" type="ORF">NSJP_0527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0527"/>
    <dbReference type="EnsemblBacteria" id="SLM46699">
        <property type="protein sequence ID" value="SLM46699"/>
        <property type="gene ID" value="NSJP_0527"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0527"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="239" mass="27393" checksum="B77363272134FAE0" modified="2017-06-07" version="1">MADSIRINKFFTQHGICSRREADRLIETGRVTINQKVAVLGDRVRSGDVIARDGKIIPWGQEAVYIKYHKPVGVTTTSEAHVPRNIIAEIGHPERIFPIGRLDKDSSGLILLTNDGDIVNAILRTEHGHEREYEVSVDRPFDRDFLDRMASGVVILGRPTKPCRLDRLGPRRFRIFLTEGRNRQIRRMCRALGYRVTELHRVRIMHITIGELAKGRWQPLTSQERDELFRAVGKSSDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1H2</accession>
    <name>A0A1W1I1H2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA synthetase/AMP-acid ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0665"/>
    <dbReference type="EnsemblBacteria" id="SLM46837">
        <property type="protein sequence ID" value="SLM46837"/>
        <property type="gene ID" value="NSJP_0665"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0665"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="109"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="473" mass="51963" checksum="624EDBC150A1E404" modified="2017-06-07" version="1">MSRMTVADTGVVGGKRATRFKAVPEYYPLLAHAGLDDCVARRDRETYSVRHFLASVRGLTSYVPAKRHAINLCKDRYHFLIGFAAALMSRHISLLPTCRAPRVFTQLKERYPDAYILTDNEDVPQDIPAYRVDHVVPTFDRMDEEIPIISSDQIAAVVFTSGSSGLPRAHAKTWGAMVMGAEALKNQFGPSDASSAMVMGTVPPQHMFGLETTIMLPLQCGWSVHAGHPVLPADIVGALSHIDQPVWLMTTPIHLRAYVRQQIDLPGLKEIVSATMPLTRSLARKAENLWHAPVREMYGCTEAGVIGTRRTTASQTWSLCSGLRLWQEGDATWVSQGHVGPPLRLVDRITIQEPTQFTLHGPSHDLVKIAGKRASLAALNAILARVDGVVDGVFYRSPTAAVADVRLTAFVVAPGVRASAIQAELRKCIDPVFLPRPLHLVESLPRNSTGKLPQDALVTFATEMALRSRRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1J8</accession>
    <name>A0A1W1I1J8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46880">
        <property type="protein sequence ID" value="SLM46880"/>
        <property type="gene ID" value="NSJP_0708"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0708"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013343140" evidence="1">
        <location>
            <begin position="28"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="140" mass="14716" checksum="DF1005C1E35F8CD5" modified="2017-06-07" version="1">MKHTLMYVLGGMALAGMSLVTVPVVQADAISLTNDAIVELTDAPGLGRRTTVDLNKRWGADVSVIASATEKLQQALTEAKSGGNARAVHLLEMAVDFGKGSMHKEARLKAQGALYNLCQTASKTDAPCDKAPKFGSYVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1K5</accession>
    <name>A0A1W1I1K5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46896">
        <property type="protein sequence ID" value="SLM46896"/>
        <property type="gene ID" value="NSJP_0724"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0724"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="80" mass="8880" checksum="1A9416EF156EC361" modified="2017-06-07" version="1">MRNVLGLKNHALACEGCKLSQNSLGVAGGIWRSINREFLTARRKAHAEVIFDQLEVSVMVTEQDSGIGAFSQLKFFHTMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1R7</accession>
    <name>A0A1W1I1R7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0765"/>
    <dbReference type="EnsemblBacteria" id="SLM46937">
        <property type="protein sequence ID" value="SLM46937"/>
        <property type="gene ID" value="NSJP_0765"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0765"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007546">
        <property type="entry name" value="DUF503"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036746">
        <property type="entry name" value="TT1725-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36441">
        <property type="entry name" value="PTHR36441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04456">
        <property type="entry name" value="DUF503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103007">
        <property type="entry name" value="SSF103007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="93" mass="10434" checksum="ABDC9407D8172C19" modified="2017-06-07" version="1">MIVGVCTVELLLSDSRSLKDKRRVLLRLKDRLHGQFNLSVAEVDGQDLWQKAVLGLACVSNEGRHANQVLDQALNLIRSDPTVELIQVKMELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1W2</accession>
    <name>A0A1W1I1W2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46813">
        <property type="protein sequence ID" value="SLM46813"/>
        <property type="gene ID" value="NSJP_0641"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0641"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="69" mass="7947" checksum="1B5078CFAA0A3090" modified="2017-06-07" version="1">MDEKTLTAVSTTLALFQIQLNAILLLLERHVPDGQIREEFQRLVSEGVQFAGMETMQSFRERIREGIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I201</accession>
    <name>A0A1W1I201_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47040">
        <property type="protein sequence ID" value="SLM47040"/>
        <property type="gene ID" value="NSJP_0868"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0868"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007485">
        <property type="entry name" value="LPS_assembly_LptE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04390">
        <property type="entry name" value="LptE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="221" mass="23783" checksum="F86C799A767DDFAE" modified="2017-06-07" version="1">MNCPPAQSPAGASRRSPARVSVADSLVLRTGLALSMAVLPVACGYQFRVEGPGPTIGGSPVAASSVPPPRLVIRTLENKSFEPNLESRFTNYIRHEFASGSGAQVVSDSEAADLMMTGQILSVIVPTLSFDQTTTFESRTEVVVAVKVEETRTKRVLWVQVAKGASEFFITTDLQFNRVLQNRALEQAGQFLAEDLASRFLLQLESGQLTKAASKLESKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I220</accession>
    <name>A0A1W1I220_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-homologous end joining protein Ku</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ku</name>
        <name evidence="5" type="ORF">NSJP_0849</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Interacts with LigD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic Ku family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0849"/>
    <dbReference type="EnsemblBacteria" id="SLM47021">
        <property type="protein sequence ID" value="SLM47021"/>
        <property type="gene ID" value="NSJP_0849"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0849"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01875">
        <property type="entry name" value="Prokaryotic_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="Ku70/Ku80_beta-barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009187">
        <property type="entry name" value="Prok_Ku"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41251">
        <property type="entry name" value="PTHR41251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006493">
        <property type="entry name" value="Prok_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SSF100939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02772">
        <property type="entry name" value="Ku_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="4">
        <location>
            <begin position="53"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="284" mass="32244" checksum="DABEDE99646F681E" modified="2017-06-07" version="1">MARKLETAHISFGLVTIPVGIYSAIDEQDIHFNQLHAPCGSRIKQQRFCPVCNRDVGYDELVKGYEVEKEHYIRITQEELDTLQAAESDAMQILEFVPLTAVDPIYFESTYYLGSEKHGEKAYQLLTQAMEQMERVALAKFVWRGKDSLYVIRAVQGRLLLHRMHYQDEIREFEHAPKSDQKPGAGELKLATQLIESISNDTFDAPAYHDEYRKRVIELIEEKAKGKTLKVSPNSAPHATEVVDLMQRLKESVAQSVQKKTARSRALPAQGARTSVKKAAAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I243</accession>
    <name>A0A1W1I243_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pyruvate kinase</fullName>
            <ecNumber evidence="4 12">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">pyk</name>
        <name evidence="15" type="ORF">NSJP_0906</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 12"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0906"/>
    <dbReference type="EnsemblBacteria" id="SLM47078">
        <property type="protein sequence ID" value="SLM47078"/>
        <property type="gene ID" value="NSJP_0906"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0906"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="13">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="14">
        <location>
            <begin position="368"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SLM47078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="484" mass="51198" checksum="568B6CEC13D0D76B" modified="2017-06-07" version="1">MRKAKIVCTIGPASESLDVLSRLIEQGMDAARLNFSHGTHDSHRRAIRSIREAAASRQAAVAIIQDVQGPRIRVDEVGEKGLDVAPGQSVRLQTALARSGGQLAAASGAPAGGQIDIPVSYPHLARDVRPGGRILIDDGLIELTVTRIAGGAVECLVVTGGRITSHKGINLPGTNVSAPTLTDKDREDIRFGVAAGVDYVALSFVRGPEDIAAAKQLVAACGRDVPIIAKIERVEAVNALPAILDAADGVMIARGDLGVEMGAEAVPVLQKRIIVEANHRRRLVITATQMLESMTQRASPTRAEASDVANAVFDGTDAVMLSAETAIGRYPVETVRVMDRIVRAAEEGIAASASRRRDADGDARSCSEAICTAASTAASAITASAIVAFSELGSTARLISKQRPVAPIIAFTPFEPIRQRMALYWGVTPHCMHQIAQTDERVHEAERRLKAEGIVKPGERIVILSGTRIGQPGGTNLMKLHEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I273</accession>
    <name>A0A1W1I273_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPM_phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_0938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0938"/>
    <dbReference type="EnsemblBacteria" id="SLM47110">
        <property type="protein sequence ID" value="SLM47110"/>
        <property type="gene ID" value="NSJP_0938"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0938"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="6">
        <location>
            <begin position="41"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="298" mass="31894" checksum="7AF0AC80F2EDE129" modified="2017-06-07" version="1">MKLARTRLVWRGPVRLFVLFTLLSVAAPLFALEAPPLTGRVVDSAHVLPASDVDWLTAALKAHEEKTGNQVAVLIIPSLEGESLEEYAHRVATTWKLGQRGTANGVLLLIAVKERRLRIEVGYGLEGTLTDLRSAHIIRDEMVPRFKAGDMPGGVRAGTEAILKTIEGTYEAKDRSAARRGWGQDTDALQLVFIGVVVGFLAGIVLSQGLRRTRALFGSLLAYLVAQSAGMILGVMAAAVTAVLLWLVLRTSRGGWRRTHDDWTWYSSRGGGWSGGSSDSGFSGGGGDFGGGGANGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2C4</accession>
    <name>A0A1W1I2C4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative NADH-quinone oxidoreductase, subunit M</fullName>
            <ecNumber evidence="4">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0994</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0994"/>
    <dbReference type="EnsemblBacteria" id="SLM47166">
        <property type="protein sequence ID" value="SLM47166"/>
        <property type="gene ID" value="NSJP_0994"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0994"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="160"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="436" mass="45907" checksum="BE790B554E4D303D" modified="2017-06-07" version="1">MTGGMMIPSLLAGIPLLGALASLPFRSDPEQLKRSCVTWAVLSLASIAGCANRIEVPTEGLLPLYLLPLAATISILGQPVHEQHRLSWLSTLVFLGIGLSVLSGPPLIAPLTVALLSALIAGLLYQHHSALWPRSWWGIGAYGFGALCAALSAAVGDPLSSLASLLACGVLLPLLPFHDGYLTALTRLPGSLPSFIVVLLPLVGLHLLAAAMPTVSDSVAWTVGFFALAGASYGAFKALAQSRVRLLLAYGSLSFFSIFWWFAAASRTATPRAALLVGTVGLATSGLMVAWQVVRTRYGDDVDPQAISGLATGMPQYAVLLSLLALAAMGLPPFGVFAGFMGLLLGSPFPSLAGLFVTLLAWLAASWYIMQMVQRLLFGIRRPELRYTDLLQAELASLLIVVLVLLALGLVPSTLFASEPAALGIPILGESFTWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2E1</accession>
    <name>A0A1W1I2E1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0969"/>
    <dbReference type="EnsemblBacteria" id="SLM47141">
        <property type="protein sequence ID" value="SLM47141"/>
        <property type="gene ID" value="NSJP_0969"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0969"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="31"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="386" mass="41660" checksum="AA1319CC4D550D52" modified="2017-06-07" version="1">MGRTFINERLARLGHSEIRAMTQACAKAGGLNLAQGVCDTPVPSVVVEAAEQAMRSGNNVYSRFDGLADLREAIAEKLVRDNRVQADPESGITVSAGATGAFHSACLALFNPGDEVIVFEPYYQYHVSALLAVEAVPVIVSMHPPQWTFSIEEVERAVTPRTRAILVNSPGNPSGKVFDRRELEAVAALARQHDLLVLTDEIYEYFLYDGASHVSMAAFPGMADRTITIGGYSKTFSVTGWRIGYAVAAPEWSKAIGAMNDLLYVCAPTPLQVGVAAGIRTLPASFYTALAKEYQGKRDRFCTALNQAGLTPSIPKGSYYVLADASRIHGRNGKDRALHVLEKVGVAGVPGEAFFSGSMGSRFIRFSYAKTDADIDDACRRLSKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2L7</accession>
    <name>A0A1W1I2L7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47256">
        <property type="protein sequence ID" value="SLM47256"/>
        <property type="gene ID" value="NSJP_1084"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1084"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="28"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="185" mass="20288" checksum="57CC4542822D7711" modified="2017-06-07" version="1">MAVSIRDNETVSYSAPRSMQTQPCLRWRALVVDGHTAIREMVRIILEPYGDLIEVVAEASDGDGAIDQALLHKVDVVLMDVNLLSPNGVETTRYLKQSMPHVVILGLSADYTPHIYNSMIAAGAVAFVRKQDAADMLFRTIVYAMFHYCRPREQDQGFGSTAPGRLGDGKPAAVSAPRTSPLPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2W8</accession>
    <name>A0A1W1I2W8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Response regulator, CheY-like (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1143"/>
    <dbReference type="EnsemblBacteria" id="SLM47315">
        <property type="protein sequence ID" value="SLM47315"/>
        <property type="gene ID" value="NSJP_1143"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1143"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="148" mass="16146" checksum="B5CC1FA6FA65B4CD" modified="2017-06-07" version="1">MAEGYGKRILVVDDNADVRFILSTVLEAAGFNVYGAGDGLEAVECLKRRRYDVLLTDYRMPKMDGLELLDMVRAMWPDLPVIMVTGDRASFKHDRLGAEAFAVVDKPFDRAHLLSLVAIAAAKGAGPGVIQQGRRRPEAAPIASAWMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I332</accession>
    <name>A0A1W1I332_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47394">
        <property type="protein sequence ID" value="SLM47394"/>
        <property type="gene ID" value="NSJP_1222"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1222"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="498" mass="55246" checksum="CE20504FA5C96260" modified="2017-06-07" version="1">MMPGIIPFRLRHFEHMPVAARDLIQTWADRLSDHQRLPAVTEMDRPIAPVEGRLLHTVGSLHLYEFVLPAGRAVTIDAPFSIVLTDDMEPTEGVALRSQGSVLLAQTGDAIGPVVTGATIVPDHAGNLASRGTRLTDMLAQADTVRFGPADRLAPMLEAGSGHEEAGGVAMLSTVWSDDPAARRQRIAALAIEAIRGNKRILLVCPDHEAADEMAGTIARAMKAGGLLYKTWISRYEMTLARESAGLPIHEVGFEAQMHQFYAKSRAEKATLRRKYERFRELTPLLAYKSQKQKDLDEVRLLEWRLLTQVNDLRRKLQEGNETLAGYEKLPLLRRLSMQAVGKNVESLHQYRELYEHQIAGLMKELEIARGRIAELAPEAAVPKEIRPEFEELKEDIVRLGGTKKIRELLAAEENTNRQAFIQNRRLVITTAARVLGDPLFSRVRFDVLIADNAPWIGAAELLGSAALVRERIILTGARQDIATAGLWTSTALPSRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I378</accession>
    <name>A0A1W1I378_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47460">
        <property type="protein sequence ID" value="SLM47460"/>
        <property type="gene ID" value="NSJP_1288"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1288"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013139603" evidence="1">
        <location>
            <begin position="24"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="103" mass="11313" checksum="47DD8EB3CBFAFD85" modified="2017-06-07" version="1">MRHLLLSLSLVGAVACWSGAAHAANPMSDKEASPTLGERLTKDTVSGTLMKMEGEYYWIKDNDGKETRIHVDKSSKIDKVVVGDHVKAYVTDRGHTTTLQRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3D1</accession>
    <name>A0A1W1I3D1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47343">
        <property type="protein sequence ID" value="SLM47343"/>
        <property type="gene ID" value="NSJP_1171"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1171"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="55" mass="6214" checksum="DEC8D27FC1F3F438" modified="2017-06-07" version="1">MLEHLLTDQMSLVQTSDPRTGAAFRNIQENAEPKSMPMTTDCPPRDRMSGLKRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3E0</accession>
    <name>A0A1W1I3E0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47485">
        <property type="protein sequence ID" value="SLM47485"/>
        <property type="gene ID" value="NSJP_1313"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1313"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="141" mass="15227" checksum="E1BBFF3DC006E892" modified="2017-06-07" version="1">MHPFWILLVNSLAGSLVVAIGAWLAWDRLSPVGGGIVFAVAAGLLAWRGKTITTIWAWVTLLLGIESFLWPILTMQQLRASTAQPSDEQMGMLLSAALTGILSAAFWLAFSYGLFKRSATPTVESVADTLPPARASSRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3E4</accession>
    <name>A0A1W1I3E4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Terminase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1227"/>
    <dbReference type="EnsemblBacteria" id="SLM47399">
        <property type="protein sequence ID" value="SLM47399"/>
        <property type="gene ID" value="NSJP_1227"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1227"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038713">
        <property type="entry name" value="Terminase_Gp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005335">
        <property type="entry name" value="Terminase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03592">
        <property type="entry name" value="Terminase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="182" mass="20868" checksum="79A43AFDB8066EDB" modified="2017-06-07" version="1">MNNLRLKHRRFVEEYVIDFNGAQAAIRAGYSKKTARQIGQRLLTNVDITKAIEQRMRHFTMQCELKTEAILRQLTRICFSDIRKIFDSDGKPLKLHQLDDDTAAAVSSMEVAGSSIKIRFWNKIDALSLAVRILNLFKEDTLAQTQEDKYVMIVPATATHEEWSKCVEQQTKQKPNGPFGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3G0</accession>
    <name>A0A1W1I3G0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1329"/>
    <dbReference type="EnsemblBacteria" id="SLM47501">
        <property type="protein sequence ID" value="SLM47501"/>
        <property type="gene ID" value="NSJP_1329"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1329"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="59"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="173" mass="19116" checksum="67E904BB18034A88" modified="2017-06-07" version="1">MKYQVVSSLRHKGKTIEMDAAREIVTLLAINGEPMGNLSWDFVIDQILAYRKPPATRESRSEPRVTLSFRVKYKTPEGQHFESRAGGIGGGGLFIESLTPLAVGTILAMEFSLPEKPHEWLPAKGLVAWVCPKADQYTFSPGMGVRFTEIAPDIRNRVVDLVKSIQHVGKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3J9</accession>
    <name>A0A1W1I3J9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47597">
        <property type="protein sequence ID" value="SLM47597"/>
        <property type="gene ID" value="NSJP_1425"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1425"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="59" mass="6662" checksum="34601025BCC913E1" modified="2017-06-07" version="1">MATQVRSCSKCFQLMWLKQDDYELLDEETIRAKCPHCGSLVRFKLTSEGANATGPKMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3M0</accession>
    <name>A0A1W1I3M0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit beta</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">atpD</name>
        <name evidence="12" type="ORF">NSJP_1420</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1420"/>
    <dbReference type="EnsemblBacteria" id="SLM47592">
        <property type="protein sequence ID" value="SLM47592"/>
        <property type="gene ID" value="NSJP_1420"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1420"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="150"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="158"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM47592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="480" mass="52294" checksum="EE82DA1BE80C7E1A" modified="2017-06-07" version="1">MSTGKVIQVIGPVVDVEFPPGHLPNIYNALKVNQEENKAAGKPAVRLTLEVAQHLGENRVRGVAMSSTDGLTRGMDVQDTGAAISVPVGRETLGRLINVLGEPVDEKGPLKAKKTYPIHRPAPKLEDQETKTEVLETGIKVVDLLEPYSKGGKVGLFGGAGVGKTVIIMELINNIALHHGGFSVFAGVGERTREGNDLWHEMQESKVIDPDDFTKSKAALVYGQMNEPPGARLRVGLTGLTVAEYFRDEENQDVLLFVDNIFRFTQAGSEVSALLGRMPSAVGYQPNLSTEMGTLQERITSTKRGSITSVQAIYVPADDLTDPAPATAFAHLDATTVLSRQLAELGIYPAVDPLDSTSRILDPQVIGEEHYKIARGVQSVLQRYKDLQDIIAILGMDELSEDDKMVVARARKIQRFLSQPFHVAEAFTGAPGKYVKLKDTVRSFKEILDGKYDHLPEQAFYMVGPIEEAVAKAEKMGVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Q1</accession>
    <name>A0A1W1I3Q1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroF</name>
        <name evidence="3" type="ORF">NSJP_1475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1475"/>
    <dbReference type="EnsemblBacteria" id="SLM47647">
        <property type="protein sequence ID" value="SLM47647"/>
        <property type="gene ID" value="NSJP_1475"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1475"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041071">
        <property type="entry name" value="DAHP_snth_FXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18152">
        <property type="entry name" value="DAHP_snth_FXD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_snth_FXD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="87"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="337" mass="36866" checksum="11EB138A382C484C" modified="2017-06-07" version="1">MIIVLRPDASEREVDHIVDRLRELGLKSQLSTGQERTIIGVIGDDRILQNQPLTALPGVESVLPILAPWKLVSREFKKDGTVIDVGGVKIGGNKLAIMAGPCAVERLELTVGIAHEVKAAGASILRGGAYKPRTSPYSFQGLGREGLDYLIEARKQTGLPVVSEILDTRDIELFLEKADIIQIGARNMQNFELLKEVGAYDKPVLLKRGLSATIKEFLLSAEYIMSRGNRNVMLCERGIRTFETQYRNTLDLAAIPTLKELSHLPVIVDPSHATGKWNLVAPMSKAAVAAGADGILIEVHSNPECALCDGEESIKPTKFKELMQDMRKIAVAVGREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3R4</accession>
    <name>A0A1W1I3R4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">trpD</name>
        <name evidence="5" type="ORF">NSJP_1462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.18" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1462"/>
    <dbReference type="EnsemblBacteria" id="SLM47634">
        <property type="protein sequence ID" value="SLM47634"/>
        <property type="gene ID" value="NSJP_1462"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1462"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="3">
        <location>
            <begin position="92"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="350" mass="37355" checksum="4A1BE62F13D6CA47" modified="2017-06-07" version="1">MSMHEFIAKIAKGQKASKDLTWDEAKRAMKSLIEGQATPAQIGAFLVAMRVKMESVTELAAFTAAARSYVAPVPTPQDINVVDLPSYAGKQDTFHALAGAAIVAAAAGAAVLMHGYDGIPGRPGQAGVLEALGVPIDLDPKAAGEAVTKQGFAYLDIGLYHPPLYRFLELRRELGVRSVFHPVARLLNPARSRSQVIGLTHPPYFEKTAEALRMLGAPRALVIRGVEGDPELSIAMVTKVLELRDDRITPLTLAPKDVGLNLGTSRDMGGFPPEQRDKEALLLRRVLQNQVQGGARDWVLYNAAMLLYAAGKESSLAACIPRAKRALEDGAAARKLEALGRQPIAAASAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3R5</accession>
    <name>A0A1W1I3R5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47642">
        <property type="protein sequence ID" value="SLM47642"/>
        <property type="gene ID" value="NSJP_1470"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1470"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013207069" evidence="2">
        <location>
            <begin position="32"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="165" mass="16808" checksum="0D4CD3B0F124917F" modified="2017-06-07" version="1">MGITGYRPSVKGICALVAAGVFLAASPAAQADNAGAEPKSIRKTCGQCPDGYAITGVTEAPSICKDGDPTLVECVPLGANLLAVCGACPDGYQEVGRSSVPSRCGRQEGGKLSQCQLQKFESTLPDPSQGRKTCPPDCGSTATPGQGAIPPPTRYLPTPEKQSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3T3</accession>
    <name>A0A1W1I3T3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47660">
        <property type="protein sequence ID" value="SLM47660"/>
        <property type="gene ID" value="NSJP_1488"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1488"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="62" mass="7449" checksum="9D44B806B8D43C60" modified="2017-06-07" version="1">MHCLKCKGFMMVERHYTMVNRRLYARCLNCGFWIDLADLLRFFHKVIDSGFRGSKVRESFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4C3</accession>
    <name>A0A1W1I4C3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Shikimate dehydrogenase (NADP(+))</fullName>
            <shortName evidence="4">SDH</shortName>
            <ecNumber evidence="1 4">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">aroE</name>
        <name evidence="7" type="ORF">NSJP_1501</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="1 4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1501"/>
    <dbReference type="EnsemblBacteria" id="SLM47673">
        <property type="protein sequence ID" value="SLM47673"/>
        <property type="gene ID" value="NSJP_1501"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1501"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011342">
        <property type="entry name" value="Shikimate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00507">
        <property type="entry name" value="aroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="5">
        <location>
            <begin position="12"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="6">
        <location>
            <begin position="250"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate binding" evidence="4">
        <location>
            <begin position="20"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="130"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="284" mass="30241" checksum="A97B8BCD9F5DD6E7" modified="2017-06-07" version="1">MNIDAHTQFCGVIGNPVEHSLSPAIHNAAFQRLGLNFVYLAWRVESIGDAIRGLRALGNFRGASVTIPHKVGVMPFLDNVEPVAGHIGAVNTIVSDKEALAGYNTDATGALRALREGGAPLKNESVAVLGSGGAARAITFALAGQAGVGRIHLLGIEEQERVALARELRDKTAVDILDAVLEEAVLRRILPEVRVLIHCTPVGMSPKVGASCVPAGLLHRDLTVMDIVYNPRHTRLLTDAAAAGCRIIAGLEMFLYQAAAQFELWTGRPAPIDVMRGVLESHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4D4</accession>
    <name>A0A1W1I4D4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1692"/>
    <dbReference type="EnsemblBacteria" id="SLM47864">
        <property type="protein sequence ID" value="SLM47864"/>
        <property type="gene ID" value="NSJP_1692"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1692"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="PTHR10801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="446" mass="51818" checksum="F226A117442CE128" modified="2017-06-07" version="1">MIPFDAYAEKRARAAASMQSLGSEGLSLEKSTSNLFRHRTGSAKPRLDLREFRHVIRIDEQARTAEVEALTTYEELVRETLPFQLMPAVVPQLKSITVGGAIAGIGIESSSFRYGFVHETMRELDVLLSDGRVVTATADNDHRDLFFGFPNSYGTLGYALRTVIDLIPIKPFVKLTHRRFTDPDRYFEAMADACRQGGADFVDGTMFDGRTFYLTTGIFVGQAEWLSDYTYLQMYYRSITEKTTDYLITHDYLWRWDTDWFWCSKHFLLQYPIMRRLWGKERLNSGVYWRLWKRAHGSRVAQLALKMIEGRQEAVIQDVEIPIEQAPRFARFFNERIGITPVWLCPVAVRDPARSYSLYPMEPGMPYVNFGFWDTVKSRHGDGHFNKLVEETVRDLRGHKSLYSTSYYSREEFDRLYNGEAYRRLKGLYDPGKRLKGLYEKCVLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4F4</accession>
    <name>A0A1W1I4F4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfopyruvate decarboxylase, beta subunit</fullName>
            <ecNumber evidence="2">4.1.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">comE</name>
        <name evidence="2" type="ORF">NSJP_1714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.79" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1714"/>
    <dbReference type="EnsemblBacteria" id="SLM47886">
        <property type="protein sequence ID" value="SLM47886"/>
        <property type="gene ID" value="NSJP_1714"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1714"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050545">
        <property type="term" value="F:sulfopyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="47"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="192" mass="20883" checksum="5EB7D6F5300AA382" modified="2017-06-07" version="1">MRPEQGTLISRAQAIGALLELLTDQPVVICNGFPSREAHKIADRATHFYMIGSMGNAPAIALGVALAKPNKQVVTFDGDGNVLMGMGTLATVGALKPKNFIHVVFDNEVYGTTGNQPTISNVVPLDKVAKAAGYVNVERVRDREDLVYEFKDMLKKDGPSMLLVKVNEFAEDAGRVLLEPPDLTKRFMKAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4I9</accession>
    <name>A0A1W1I4I9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1765"/>
    <dbReference type="EnsemblBacteria" id="SLM47937">
        <property type="protein sequence ID" value="SLM47937"/>
        <property type="gene ID" value="NSJP_1765"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1765"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="204" mass="22096" checksum="CECF1958025804EF" modified="2017-06-07" version="1">MLAGAAMGLLTPLIAEITAENLSLVGEVTADELGLTERDAVIRAPLSVSLDLMKADDMIAVTGVVEGTAVRQCVRCLREYDDALAFSVHAAYAREGKEATKDPHPGGRQTRTSDVRKGKPVHGKGEPVAEEEAEDDDRYFYQGDHLDLAPMLREHVILAAPMQPICREECAGLCPRCGQDLNEGPCQCPAEPVPTAFRVIRNMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4R2</accession>
    <name>A0A1W1I4R2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiol-disulfide oxidoreductase ResA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">resA</name>
        <name evidence="3" type="ORF">NSJP_1822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1822"/>
    <dbReference type="EnsemblBacteria" id="SLM47994">
        <property type="protein sequence ID" value="SLM47994"/>
        <property type="gene ID" value="NSJP_1822"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1822"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="47"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="207" mass="23014" checksum="6153E34FBE2C190C" modified="2017-06-07" version="1">MPLLDQSMPVSTSKPGPTRLLILIAGTVILVLTFAIVWLQSAKYEPLAVGKSAPDFALSDLNDKSYRLSDFRGKVVFLNFWATWCKPCREEMPSMEILNKNFEKDGLVILAVSIDRVTTTKEIPPFVKGLNLTFPVLIDSWGKTDKPYKRMGVPETFIIDQEGIIREIVIGPRDWTRLDSLQILTKLLNVTPKAATIGPAGLTIVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4R3</accession>
    <name>A0A1W1I4R3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Squalene--hopene cyclase</fullName>
            <ecNumber evidence="7">4.2.1.129</ecNumber>
            <ecNumber evidence="7">5.4.99.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">shc</name>
        <name evidence="7" type="ORF">NSJP_1836</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; hopanoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.129" evidence="7"/>
    <dbReference type="EC" id="5.4.99.17" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1836"/>
    <dbReference type="EnsemblBacteria" id="SLM48008">
        <property type="protein sequence ID" value="SLM48008"/>
        <property type="gene ID" value="NSJP_1836"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1836"/>
    <dbReference type="UniPathway" id="UPA00337"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051007">
        <property type="term" value="F:squalene-hopene cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006400">
        <property type="entry name" value="Hopene-cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002365">
        <property type="entry name" value="Terpene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="PTHR11764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01507">
        <property type="entry name" value="hopene_cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01074">
        <property type="entry name" value="TERPENE_SYNTHASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SQHop_cyclase_N" evidence="6">
        <location>
            <begin position="79"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="SQHop_cyclase_C" evidence="5">
        <location>
            <begin position="391"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="734" mass="82938" checksum="97192555DC95178C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4U1</accession>
    <name>A0A1W1I4U1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="8">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">folD</name>
        <name evidence="11" type="ORF">NSJP_1779</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1779"/>
    <dbReference type="EnsemblBacteria" id="SLM47951">
        <property type="protein sequence ID" value="SLM47951"/>
        <property type="gene ID" value="NSJP_1779"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1779"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="1 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5 8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="9">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="10">
        <location>
            <begin position="124"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM47951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="286" mass="30150" checksum="91FF75750437ECE9" modified="2017-06-07" version="1">MAAKLIDGKALAQQVRDGLAAQAAKVLAKTGTKPGLATILVGDDPASHVYVKNKQKACELAGIYVDDHKLPSSTTQAELLALIDKKNADPKIHGILVQLPLPKHIDSKVILEAVSPDKDADGFHPYNFGRLVEGHPVFEACTPKGVIKMIESTGVTIEGKRAVVLGRSNIVGKPLALMLLQRNATVTICHSKTKDLAAVCREADLLLVAIGKAKFVTADMVREGAVVIDVGTNKTSDGKLCGDVDFEPVSQKAGWISPVPGGVGPMTIAMLLDNTVESARRMAGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Y8</accession>
    <name>A0A1W1I4Y8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48078">
        <property type="protein sequence ID" value="SLM48078"/>
        <property type="gene ID" value="NSJP_1906"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1906"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="916"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1219"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1351"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1418"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1723" mass="192877" checksum="61D21C0A536AC28B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I537</accession>
    <name>A0A1W1I537_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48110">
        <property type="protein sequence ID" value="SLM48110"/>
        <property type="gene ID" value="NSJP_1938"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1938"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="75" mass="8212" checksum="088D2A7F4C745103" modified="2017-06-07" version="1">MRTRILHFETCDITLAFSLIPILALAASALIEQLPFLALLMGLLIGLASILQKLDGFLGTTAIPLILNFLFRCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5H0</accession>
    <name>A0A1W1I5H0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2095"/>
    <dbReference type="EnsemblBacteria" id="SLM48267">
        <property type="protein sequence ID" value="SLM48267"/>
        <property type="gene ID" value="NSJP_2095"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2095"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044005">
        <property type="entry name" value="DZR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18912">
        <property type="entry name" value="DZR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DZR_2" evidence="2">
        <location>
            <begin position="20"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="157"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="275" mass="30326" checksum="FECBAD216D3B8EBE" modified="2017-06-07" version="1">MLTSFPFTRTGFLGLCRQALRFIVPVDCLACGVGLQGDPVPGFCRRCWELILPLKGPCCALCSQPFVSAAAVSNSPNHHCQDCLEHRPAFSRAWTLYPYLPPLREAVCAFKYRGKIGLAKPLAQLMIDALPPNLDVDLVLPVPLHPSRLRGREFNQSLLLADRVARHLHLPVSIRELARVHATDPQTTLPRNMRLKNVRHAFAVRRPRLVTGRRILLIDDVFTTGATLHECAAALSESGAKSVVALTLARTIGSLVVPDHLFVEEPFRSPSVLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5I3</accession>
    <name>A0A1W1I5I3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nadD</name>
        <name evidence="8" type="ORF">NSJP_2105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2105"/>
    <dbReference type="EnsemblBacteria" id="SLM48277">
        <property type="protein sequence ID" value="SLM48277"/>
        <property type="gene ID" value="NSJP_2105"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2105"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="22"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="236" mass="26271" checksum="3FB17C64577161FD" modified="2017-06-07" version="1">MGSQECLSPPDTSSLRSLRLGLLGGTFNPVHCGHLTMARQIRRALDLDRILFIPTGDPPHKSRQDLASADDRYAMVRLAIASEAGLAISDVELRRPGKSYTIDTVRLLRQEYGSQTELFFLIGLDAFLEFPTWREPDALLELCSFVVMNRPGTSFQHLTRLSWFQTFPGDSLAALDAGTISQVDIPIGNRRLICLRLTPSDISASDIRGRVRTGLPVANLLPPTVESYILQHHLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5J7</accession>
    <name>A0A1W1I5J7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1931"/>
    <dbReference type="EnsemblBacteria" id="SLM48103">
        <property type="protein sequence ID" value="SLM48103"/>
        <property type="gene ID" value="NSJP_1931"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1931"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="10"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="90" mass="10544" checksum="3B855EBD7ECC9419" modified="2017-06-07" version="1">MSNRYTAPISILFVDPDIEGRAYWLRRLATSSPDYFVRTVEDGHTALKLCKFRKFDCVVLELVLPDISGFEVLINLCPPWHRNPRSRWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5K8</accession>
    <name>A0A1W1I5K8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48302">
        <property type="protein sequence ID" value="SLM48302"/>
        <property type="gene ID" value="NSJP_2130"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2130"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="2">
        <location>
            <begin position="101"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="209" mass="23082" checksum="DC2EBA932795854D" modified="2017-06-07" version="1">MTTLTVAESQPAGNPSKQIPHGMQQGYVLWIGVLLFLYSALFFTLAFFGPHLQPLVTLYTGGSLADRQEAALQLLSLSETVWVAVPVLFLGAAIFSLVLTKRVAGPLQVLEQSIVRWAEGDLATRLRFRQVDRLDALEKSINEGIQAIETSLMTFAREQARAEKALGQVRSALETHPGSPQKALQGLDEAGDAFAKMREALRKFRFTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5L9</accession>
    <name>A0A1W1I5L9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribonuclease</fullName>
            <ecNumber evidence="10">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rnhC</name>
        <name evidence="12" type="ORF">NSJP_2007</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase HII family. RnhC subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2007"/>
    <dbReference type="EnsemblBacteria" id="SLM48179">
        <property type="protein sequence ID" value="SLM48179"/>
        <property type="gene ID" value="NSJP_2007"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2007"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004641">
        <property type="entry name" value="RNase_HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00716">
        <property type="entry name" value="rnhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="11">
        <location>
            <begin position="9"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM48179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="215" mass="23391" checksum="DDC9D07AE461F185" modified="2017-06-07" version="1">MPGPVIERIGIDESGKGDYFGPLVIAAVFVDATTQAELTLIQIRDSKKISDGRILEMAPDIKTICPHSIIAIGPQKYNELYTKIRNLNRLLAWGHAKALENLLERVPCSLAISDQFGDERLILNALQAKGRTITLQQRTGAESDLAVAAASVLARAEFLMRLKRLSEDVGTTLPKGASPSVELAGRMVVKKHGRDRLGTVAKLHFKTTKAVLGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Q0</accession>
    <name>A0A1W1I5Q0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48320">
        <property type="protein sequence ID" value="SLM48320"/>
        <property type="gene ID" value="NSJP_2148"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2148"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="117" mass="13179" checksum="E27274510E976C76" modified="2017-06-07" version="1">MPDDRGGHGAQNTGMDLARSRTEQQPPGRYELTSDHPITPTSIGERQYSEVPKSEAMGNMLTRTRLITIPRGFEVKNCHVIVTSRWTLSRIPLFRILFRPRSPTPRPGGAPRTFLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5T5</accession>
    <name>A0A1W1I5T5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2173"/>
    <dbReference type="EnsemblBacteria" id="SLM48345">
        <property type="protein sequence ID" value="SLM48345"/>
        <property type="gene ID" value="NSJP_2173"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2173"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="24"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="179"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="257" mass="28242" checksum="254F08E72D209F88" modified="2017-06-07" version="1">MEETITIQDDLGHHVSAVLSSPVQARGTVVLCHGFLSNKHSTTNKTLTRLFNEQGFATFRFDFFGHGESDGRFEDITVSLALGQAKAAVDFVAARGHGPIGLVGSSFGGLVAILAVAERPAISCLGLKCPVVDFAEELRLEFGVEELARWKDTDRVPDIHGGPNRMRLNYRLYEDSLVRVAYEPATRITAPTLIVQGDCDELVPLHQSRQLMDALQGPKRLDLLPGADHQFSRGEDFRTMTTAIADWLILHLAPPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5V6</accession>
    <name>A0A1W1I5V6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maltose alpha-D-glucosyltransferase</fullName>
            <ecNumber evidence="3">5.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Maltose alpha-D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">treS</name>
        <name evidence="8" type="ORF">NSJP_2225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-maltose = alpha,alpha-trehalose</text>
            <dbReference type="Rhea" id="RHEA:15145"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="EC" id="5.4.99.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. TreS subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.16" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2225"/>
    <dbReference type="EnsemblBacteria" id="SLM48397">
        <property type="protein sequence ID" value="SLM48397"/>
        <property type="gene ID" value="NSJP_2225"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2225"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047471">
        <property type="term" value="F:maltose alpha-D-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012810">
        <property type="entry name" value="TreS/a-amylase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02456">
        <property type="entry name" value="treS_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="7">
        <location>
            <begin position="15"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="558" mass="65248" checksum="DBF18507FBD6B712" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5W9</accession>
    <name>A0A1W1I5W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48394">
        <property type="protein sequence ID" value="SLM48394"/>
        <property type="gene ID" value="NSJP_2222"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2222"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="47" mass="5208" checksum="A825047AECEEC25B" modified="2017-06-07" version="1">MHIKKQPSQKPESTLRYGEPGTGISRPPDSDIHFEKTGSRSVNLTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I609</accession>
    <name>A0A1W1I609_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48309">
        <property type="protein sequence ID" value="SLM48309"/>
        <property type="gene ID" value="NSJP_2137"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2137"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="183" mass="20439" checksum="077EDA01C03E6117" modified="2017-06-07" version="1">MFRRLQQSVGACVCVMMLTGVLVGSIRAGMKEMTEQVSPAVVGAGKKSMEKPSTKQGAFSRDPSKRLSVGDRKAQATQRHKHAIGSSSSRRSKTLPRAEVTRTSKATLMSQPSQRDLAGYGLLETLQRYDPRLNHRTAGMPIAQTPDITRDHFFELDRNRDGHVDPVERAFGRLDMERDFQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I637</accession>
    <name>A0A1W1I637_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2316"/>
    <dbReference type="EnsemblBacteria" id="SLM48488">
        <property type="protein sequence ID" value="SLM48488"/>
        <property type="gene ID" value="NSJP_2316"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2316"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="272" mass="30258" checksum="375AACB8A144A73A" modified="2017-06-07" version="1">MEQSETHDQDLHKEAGSDAASDELTDQVAAELTGETAVAETTDEQPEAVLLEEEKPKDEIDIQIDLLKDPDWVVRREAAITLGEMADERCVEPLCQALRDGDWQVREVAVDGLGQIGSPAVELLLKLLRDWDVRKYAIGALGKIRDERVLDPLMLQLRNDEFKDDATNALVELGAPALSRLIVALKDKDELVRKQAVLALGRIKHTDAIDPLIDMLADKDWFTRLTAAAALEAIGDDRGREAIKPLTKDSDMVVRMRAERILAKWKKQPANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6A0</accession>
    <name>A0A1W1I6A0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3 7">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">malQ</name>
        <name evidence="8" type="ORF">NSJP_2299</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3 7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2299"/>
    <dbReference type="EnsemblBacteria" id="SLM48471">
        <property type="protein sequence ID" value="SLM48471"/>
        <property type="gene ID" value="NSJP_2299"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2299"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00217">
        <property type="entry name" value="malQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="749" mass="82996" checksum="86A2751F2465B0DD" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6F3</accession>
    <name>A0A1W1I6F3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type transport system, ATPase component</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_2414</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2414"/>
    <dbReference type="EnsemblBacteria" id="SLM48586">
        <property type="protein sequence ID" value="SLM48586"/>
        <property type="gene ID" value="NSJP_2414"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2414"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="295"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="509"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="327"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="613" mass="67858" checksum="C5EC8C9158BD2EDE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6K2</accession>
    <name>A0A1W1I6K2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative O-methyltransferase, family 2</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_2464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2464"/>
    <dbReference type="EnsemblBacteria" id="SLM48636">
        <property type="protein sequence ID" value="SLM48636"/>
        <property type="gene ID" value="NSJP_2464"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2464"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031725">
        <property type="entry name" value="ASMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="PTHR11746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16864">
        <property type="entry name" value="Dimerisation2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dimerisation2" evidence="5">
        <location>
            <begin position="12"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_2" evidence="4">
        <location>
            <begin position="128"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="351" mass="39418" checksum="A450123413C46E8E" modified="2017-06-07" version="1">MTGPPETFSEFRDLLAGYRLPRIILTALELKLFTAMGTSTWTPSQLARLLKVSERGVTILCRNLAMAGLLVKKGTRYRNGRLGSTLLNARHPAYRGRYLDLLTSQWNDWAGLTESVRTGKPVDHDEPDQPDHRSRFTWAMHQRTMDLAPRLAERISLRGARSLLDLGGGPGTYALAFLAKNRELKATVCDRPAALRVAKTIAKNHQAGARLWYLPLDLLADPIPGSYDVVWYSNVLHIYSPEQNRSIFRRVRAALNPGGRFIIQDAFLHDREGLRPEDASLFAVSMLLFTETGDTYRAAEVTAWLNAAGFESVRLLRTKKGQEDWEGGVLEARLPRAIARTRANRRRSAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6K8</accession>
    <name>A0A1W1I6K8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48624">
        <property type="protein sequence ID" value="SLM48624"/>
        <property type="gene ID" value="NSJP_2452"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2452"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="331" mass="35757" checksum="4E68F02C74E5AE39" modified="2017-06-07" version="1">MVLVLADTTDPWASLVHAELCRRGLDVLLIPRAELLDRIRLNWPMAAGSPTVAGTMVIDGRSFECGALRGVFVQWVLPLPLLLDDLSVQDRDYVLRETTAAWIAFLNSLPCPVINRPVPGGRPALLGGSAVSAQIARDCGFDLPAARYTSSEADAVLQFAAWNEQAYLKALGSAEPGVVLSRQNGIEHIRQVMERHAVSLQAIPQGQRMTVYVVGGDAAATILHADEESSQRTADLPVFPTGRCVDLVRALGLSFAECHVVVAADGRICCLDVNGAPNYWRCTRAVQRRLVQRLADCLSEERSMAFYDSARGTHGGSGAGQRLCQTGGPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6L1</accession>
    <name>A0A1W1I6L1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2496"/>
    <dbReference type="EnsemblBacteria" id="SLM48668">
        <property type="protein sequence ID" value="SLM48668"/>
        <property type="gene ID" value="NSJP_2496"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2496"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="225"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="529" mass="58947" checksum="F4D2DF3E7F39F952" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6L8</accession>
    <name>A0A1W1I6L8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="7">IMP dehydrogenase</shortName>
            <shortName evidence="7">IMPD</shortName>
            <shortName evidence="7">IMPDH</shortName>
            <ecNumber evidence="7 13">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 15" type="primary">guaB</name>
        <name evidence="15" type="ORF">NSJP_2484</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 13">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 12">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="7 13"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2484"/>
    <dbReference type="EnsemblBacteria" id="SLM48656">
        <property type="protein sequence ID" value="SLM48656"/>
        <property type="gene ID" value="NSJP_2484"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2484"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 7 13" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 13" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="14">
        <location>
            <begin position="94"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="14">
        <location>
            <begin position="153"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="337"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="360"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="384"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="7 8">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="247"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="297"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SLM48656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="488" mass="52163" checksum="C4DB561E0D6431A6" modified="2017-06-07" version="1">MLDKEPRLGLTYDDVILVPAKSAVLPSEVDVRTQLSRNIQINVPIISSAMDTVTESRMAIAMAREGGLGIIHRVLSPADQAAEVDRVKKSESGMILDPVTISPDETIRDAHQLMAKYRISGIPVTKNKKLVGILTNRDLRFETRMDLKVAQVMKRDKLVTAPEGTSLEKAREILHEHRIEKLPVVNKQGELKGLITIKDIEKRIKYPNACKDTHGRLRVGAAVGVGPDTEDRVALLKRAGVDLVVVDTAHGHSQAVLDMVKLIKKQYAALEVVAGNIATAEAAKDLLKAGVDAVKVGVGPGSICTTRIVSGSGMPQLTAIADCAKALAGSGVPIVADGGIKFSGDITKALSAGASSVMLGGLLAGTEESPGETVLYQARTYKVYRGMGSIGAMERGGGDRYGQGGRPAPKLVPEGIEGRVPYKGPISAVMYQLVGGVKSGMGYCGCRTIPDLQQKATFIRQTVAGLRESHVHDVIITKEAPNYRMDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6T4</accession>
    <name>A0A1W1I6T4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cation/multidrug efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2543"/>
    <dbReference type="EnsemblBacteria" id="SLM48710">
        <property type="protein sequence ID" value="SLM48710"/>
        <property type="gene ID" value="NSJP_2543"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2543"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="211" mass="23557" checksum="09306C284ADEC6C1" modified="2017-06-07" version="1">MDSTLTVVAIGFGVLGLAFLWTAVAAVRRRRFLRFSLHSGVALACLAAGLLLLTIHLSLQGYQALTREDLAATIRAESTGPEEFLVTMRFPDGRLETYALGGNEIYVDAHILKWKSWANLIGLHTAYELDRISGRYHDIADERAKPRTIYALSSDRLIDVFTLRRRYAWLAPLVDAEYGSAAFIPARDQATYELRISTTGLLFRSPATDHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Z5</accession>
    <name>A0A1W1I6Z5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc metalloprotease</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ecfE</name>
        <name evidence="11" type="ORF">NSJP_2620</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48787">
        <property type="protein sequence ID" value="SLM48787"/>
        <property type="gene ID" value="NSJP_2620"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2620"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00054">
        <property type="entry name" value="TIGR00054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="149"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="209"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="463" mass="50049" checksum="E516BC4BB1EDE89D" modified="2017-06-07" version="1">MFMALTWAPDSVWLLLQKAWWFLVVLGVLVAFHELGHFLAARWVGVKVLKFSLGFGPKIFGRQMGETEYLVSAIPLGGYVKLFGEDEAEAITPEDRRRSFVHQGLWGKVLIVAAGPGFNFILAYLIFAGWLATGSPLFVPTFKDLSADVEAMVPGSPAAEAGMQIGDRVTKVNGRDISTRTELFDAVAKSNGQAISLEILRDGRTKAISVVPSKPASSSQTEDIPYSLGIEETPALVTSVMHGSPAAHAGLQAGDRVVSIDNQPIYTWSQMTGLVKDHPNQPLHLEVVRESRRMPLTVTPSGEKTTVNGRQVEVGKIGISGPGRSVMRSSNPLLSLYDGLGATWGWTELTAVGLYKMIVGDISSKNIGGPLTIANISGEAASQGVSSVIFLIAILSINLGVLNLLPIPILDGGHLLFFLIEGILRKPLGERQREVAQQVGLVLLVGVMIFAFWNDLERIFFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I706</accession>
    <name>A0A1W1I706_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vitamin B12-dependent ribonucleotide reductase</fullName>
            <ecNumber evidence="11">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">nrdZ</name>
        <name evidence="14" type="ORF">NSJP_2635</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="11"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2635"/>
    <dbReference type="EnsemblBacteria" id="SLM48802">
        <property type="protein sequence ID" value="SLM48802"/>
        <property type="gene ID" value="NSJP_2635"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2635"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02888">
        <property type="entry name" value="RNR_II_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013344">
        <property type="entry name" value="RNR_NrdJ/NrdZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02504">
        <property type="entry name" value="NrdJ_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="10 11" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 11" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuc_red_lgN" evidence="12">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="13">
        <location>
            <begin position="78"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM48802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="565" mass="62748" checksum="C0500E961AB46E6B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I723</accession>
    <name>A0A1W1I723_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nusB</name>
        <name evidence="8" type="ORF">NSJP_2441</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2441"/>
    <dbReference type="EnsemblBacteria" id="SLM48613">
        <property type="protein sequence ID" value="SLM48613"/>
        <property type="gene ID" value="NSJP_2441"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2441"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="7">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="146" mass="16709" checksum="24D04256A7648085" modified="2017-06-07" version="1">MGSRHQSRERALQILFQYDIHGKPGVWLDEFWNQCEATEDVRAFAEELVRGVLEHRAELDALLGRYATNWKVSRMQVVDRNILRLGIYELLWREDVPAKVTMNEAIELAKDFGDDEAAKFVNGVLDKVLAAEARLEAKRKAASGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I754</accession>
    <name>A0A1W1I754_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Histidine kinase, contains GAF domain</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2657"/>
    <dbReference type="EnsemblBacteria" id="SLM48824">
        <property type="protein sequence ID" value="SLM48824"/>
        <property type="gene ID" value="NSJP_2657"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2657"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="206"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="425" mass="47050" checksum="DA6A996535AF1C95" modified="2017-06-07" version="1">MSTRPANPASDSSPTTEFFDQLTRFSIDLGAMTDLGPLSERALQELSRVGGATHGALYLLDREHEYYRRAATTGSPAKTKLPESIALDHPVPHRLSSPQSEIASHHTASFGGSFALDVSDEPALAALGMALALPHISRGQLIAFSLLDAAQPRGQHAASVHALLAVLAQTATNAVDRLMLYEDLHRSHLLMKRTDRLKSLETIAGGFAHEIRNPLTSIKTFIQLAPERKDDPDFIRDFSRIVLDDVYRIERLIDEILDYARYMEPKLTEEDINDIVSSCLYFIDVKADTKGIRIEKELATNLPRVMLDRQQVKQVFLNLFLNALDAMGKAGGFLRVRTKLLNRPGGRVWVQVETEDTGEGIPEGNLEHIFDPFFTTKHESGEHEGTGLGLTIVHQIVQEHRGEIEVRSVPGKGTTFLVNLPALSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7C9</accession>
    <name>A0A1W1I7C9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0301 (AlgH) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2749"/>
    <dbReference type="EnsemblBacteria" id="SLM48916">
        <property type="protein sequence ID" value="SLM48916"/>
        <property type="gene ID" value="NSJP_2749"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2749"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003774">
        <property type="entry name" value="UPF0301"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30327">
        <property type="entry name" value="PTHR30327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02622">
        <property type="entry name" value="DUF179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="198" mass="21318" checksum="015933A2F7515CD2" modified="2017-06-07" version="1">MVAWALSAVLFAAQADADGTFGPSSVKRGVLLVASPTLGDPNFRESVVLIVEHGEEGTLGVILNRPTEVLLSEVLPDIAALKGTRYQLFAGGPVQPAQLLMLFRLKEPQAYARSVFDGVYVGGTPEILERVIRQPKPTETFKAFAGSAGWAPGQLAYEMHQGAWAVLAPDAAGIFDRKPSTLWRDCLDRLQAPRAIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7E9</accession>
    <name>A0A1W1I7E9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_2763</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2763"/>
    <dbReference type="EnsemblBacteria" id="SLM48930">
        <property type="protein sequence ID" value="SLM48930"/>
        <property type="gene ID" value="NSJP_2763"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2763"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008168">
        <property type="entry name" value="Cyt_C_IC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00605">
        <property type="entry name" value="CYTCHROMECIC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012415909" description="Cytochrome c domain-containing protein" evidence="5">
        <location>
            <begin position="25"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="31"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="115" mass="12479" checksum="E5F7F6E977D42BE7" modified="2017-06-07" version="1">MKDRMAVYGFLAAWIWWVLPPATAQSGAGHGDVAKGKVLFERNCAGCHGAEGKGNGYKLLGPDPADLTSRRTAAKSDGELLKTIHDGKPNMPAWKNLLSDEQARDVLVYVRTLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7F4</accession>
    <name>A0A1W1I7F4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48978">
        <property type="protein sequence ID" value="SLM48978"/>
        <property type="gene ID" value="NSJP_2811"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2811"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="56" mass="6221" checksum="DFD5FE7CB158BD18" modified="2017-06-07" version="1">MTVFLIGVLTVTALVSLIVVTLGNESDARRRQIVRDKSNASSEERRVDYVESRQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Q3</accession>
    <name>A0A1W1I7Q3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2885"/>
    <dbReference type="EnsemblBacteria" id="SLM49052">
        <property type="protein sequence ID" value="SLM49052"/>
        <property type="gene ID" value="NSJP_2885"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2885"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="137" mass="15335" checksum="11F3BFF7296206F7" modified="2017-06-07" version="1">MASQPTETSVDRPVDPLVTWARVVYALHAFSLLTAIIGTATLVGAFLTGWPSIIAVILNYLKRSEVRGTWLESHFRWQIRTFWFGLLWVSLCVAFVVATLGIGILVAWLPLGVVGLWFVYRIVRGWVTLGDGRPMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7R6</accession>
    <name>A0A1W1I7R6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">glgP</name>
        <name evidence="11" type="ORF">NSJP_2867</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2867"/>
    <dbReference type="EnsemblBacteria" id="SLM49034">
        <property type="protein sequence ID" value="SLM49034"/>
        <property type="gene ID" value="NSJP_2867"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2867"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="PTHR11468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM49034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="833" mass="93409" checksum="FDA2F85EF0158D1F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Y4</accession>
    <name>A0A1W1I7Y4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49095">
        <property type="protein sequence ID" value="SLM49095"/>
        <property type="gene ID" value="NSJP_2928"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2928"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="73" mass="7738" checksum="0E455B6327E5851A" modified="2017-06-07" version="1">MTARAMGVSQEAPPSSYRHIGWGSLVGSLLAVSIAQAQIAPPIFDPSGRSSCRPLPCRPRNRPSSDWARSGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I821</accession>
    <name>A0A1W1I821_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49150">
        <property type="protein sequence ID" value="SLM49150"/>
        <property type="gene ID" value="NSJP_2983"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2983"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="123" mass="13398" checksum="E704A1C9DBF4814B" modified="2017-06-07" version="1">MAERVGFEPTVPLPGQQFSRLPDSAALAPLRVLVRLTLGGTGKPPFNSAATGAYPASRHFSIGFPAGRSSGFPSSSRHLIPGIFTMIFGPKLGFLLWFWEFVYYVVCWRSVLRGNSLVGILIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8B1</accession>
    <name>A0A1W1I8B1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pvuIIM</name>
        <name evidence="8" type="ORF">NSJP_3073</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3073"/>
    <dbReference type="REBASE" id="194838">
        <property type="entry name" value="M.NjaNJ11ORF3073P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49240">
        <property type="protein sequence ID" value="SLM49240"/>
        <property type="gene ID" value="NSJP_3073"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3073"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="7">
        <location>
            <begin position="73"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="346" mass="39766" checksum="830368F091CB5E34" modified="2017-06-07" version="1">MVSLLIQCAELIRSRTIAPQFPLHRMNRMPKRPVKSELNTLKKAYISTRGLMLSGRSEQFLRSRRAKRLGGKIQLIFTSPPFPLNHKKKYGNLTGDAYVDWFASFAKPFRKLLTRDGSIVIELGNAWEAGKPVMSTLALRALLAFQERGDFNLCQQFICYNPARLPSPAQWVNVERIRVKDSYTHLWWLSPSERPKADNRRVLKQYSDSMLRLLSSNKYNSGHRPSQHRIGEKSFLKNNNGAIPSNVLILSNTNSTDPYLKYCRKEGLPLHPARMPTQLAEFFIKFLTTPRNLVFDPFAGSNTTGAAAETLKRRWLSVEAERDYILGSRVRFRATRRGQNDKRRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8W8</accession>
    <name>A0A1W1I8W8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49243">
        <property type="protein sequence ID" value="SLM49243"/>
        <property type="gene ID" value="NSJP_3076"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3076"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="89" mass="9813" checksum="7AB3C1BB46042D4C" modified="2017-06-07" version="1">MDQIRRDHRETRQFLRNPRRRTRQERTHRLANATPAQPVGGLQRADGLSPAPSYSGEAPGGQAWDSGPRGGGPGIGSQRVTVPIIFETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I913</accession>
    <name>A0A1W1I913_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NSJP_3337</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM175 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3337"/>
    <dbReference type="EnsemblBacteria" id="SLM49504">
        <property type="protein sequence ID" value="SLM49504"/>
        <property type="gene ID" value="NSJP_3337"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3337"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010617">
        <property type="entry name" value="TMEM175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06736">
        <property type="entry name" value="TMEM175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="164"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM49504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="214" mass="24037" checksum="2BC8C090B5E58AE6" modified="2017-06-07" version="1">MKVLHLFLKRSHTHERLCAVSDGVYAIALTLLVLDLKVPEVRGITNSELTTDLVEQLPNFVAYVVAFFLVARFWINHHRIFQSAALCDEKALSLNLAHLFFISLTSYTASLIGHYEGDRIATIIFSSNLGLSSLTLSILGHYVLERKEWRTKESGGTWVKISWWTAYTAPGVALASILVSFLSINAALLLWLVVPLRDLMLLNRLSSPHVHQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I951</accession>
    <name>A0A1W1I951_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49333">
        <property type="protein sequence ID" value="SLM49333"/>
        <property type="gene ID" value="NSJP_3166"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3166"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023204">
        <property type="entry name" value="SP1917_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014580">
        <property type="entry name" value="UCP033199"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09966">
        <property type="entry name" value="DUF2200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033199">
        <property type="entry name" value="UCP033199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="116" mass="13420" checksum="4E2F1639D183CB0A" modified="2017-06-07" version="1">MTKHRIYTISFARVYPMYISKAEKKGRTKAEVDEIIRWLTGYSQKKLDAKLKQQADVETFFSEAPQLNPSRALIKGVVCGVRVEDVAEPTMREIRYLDKLIDELAKGKAMEKILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I975</accession>
    <name>A0A1W1I975_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49564">
        <property type="protein sequence ID" value="SLM49564"/>
        <property type="gene ID" value="NSJP_3397"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3397"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="78" mass="8631" checksum="90D6EC7E65E0A9E1" modified="2017-06-07" version="1">MSTEWINRLTTLQRTLTVCPTNGSARCELASLLERLNQSEEALVHWKMLLAADPNSLQAREGIARCAPKVGRPLQSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9E6</accession>
    <name>A0A1W1I9E6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3443"/>
    <dbReference type="EnsemblBacteria" id="SLM49610">
        <property type="protein sequence ID" value="SLM49610"/>
        <property type="gene ID" value="NSJP_3443"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3443"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="589" mass="66221" checksum="EA095A1CA5A93DA3" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9G1</accession>
    <name>A0A1W1I9G1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Blue (Type 1) copper protein, cupredoxin family (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49654">
        <property type="protein sequence ID" value="SLM49654"/>
        <property type="gene ID" value="NSJP_3487"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3487"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupredoxin_1" evidence="1">
        <location>
            <begin position="34"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="139" mass="14692" checksum="3EF5F9262B4CE7EB" modified="2017-06-07" version="1">MNAHLRSLTLLAGIFLIGSDPVIGGTGPGDTGIVEILFESSAPYYEPPLAVVSAGIPVRWSNATASPHSIRHDECLKEDGQCVFQSLAVPPENSFAIAPLPPGRYSYHCELHPVMRGTLVVVESQAATEMSGPSAHSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9J5</accession>
    <name>A0A1W1I9J5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3372"/>
    <dbReference type="EnsemblBacteria" id="SLM49539">
        <property type="protein sequence ID" value="SLM49539"/>
        <property type="gene ID" value="NSJP_3372"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3372"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012484084" evidence="1">
        <location>
            <begin position="27"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="349" mass="37270" checksum="52EB440BF9C64CA2" modified="2017-06-07" version="1">MTVIASRLLQLLWFVILAGLAFPAAAQHGPQPDDPTQTIPAQQAASIQALTAAGNQSLYAGSFGHGLFHSGDRGATWTKSGDGITDPFILSLATSKDGTVYAGTFRGGVFRTRDHGKTWRPVNDGLKRHEIKTLLPVGDVLYAGTADGAYRLGRGEDRWAVVTTGLDEILVHALAQSSDGTLYAGTSGKGVLRFKANSTGWVRLRQGLKDHEGMIENFIRVLTIDSEGAIYAGTFDGGVFRSEDAGATWRPISRALPNDSIRGIVFNTRGLFVATGHGIFKTVDRGRQWTPLNNGLTSMSVQVLIESDSGSLYAGTNAGAFRSDDDGKTWAAINHGLEGGLPPPPFLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9K5</accession>
    <name>A0A1W1I9K5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3498</name>
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    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3498"/>
    <dbReference type="EnsemblBacteria" id="SLM49665">
        <property type="protein sequence ID" value="SLM49665"/>
        <property type="gene ID" value="NSJP_3498"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3498"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="242" mass="26631" checksum="132A2F9E0A3FC577" modified="2017-06-07" version="1">MAQVTEIAPDVFRLTTFIEAFDLQFSQFLVRDEEPLLFHTGPRALFPMVKEAVASLIDPAALRWIGFSHFEADECGTLPEWQGIASEATAVCSMVGKLVSVDDCLAVRPARGMSDGEVLSTGKYRFRFLSTPHVPHCWEAGLLFEEVNRTLFCSDLFHQSGNVEPVAGVEVLERCRKVLVEYQQGPLANYIPYSTLTEPTLYRLAELNPKTLAAMHGSALAGDGAGALRELAAIWKDVLATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9P8</accession>
    <name>A0A1W1I9P8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cobinamide/cobalamin adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yvqK</name>
        <name evidence="6" type="ORF">NSJP_3548</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3548"/>
    <dbReference type="EnsemblBacteria" id="SLM49715">
        <property type="protein sequence ID" value="SLM49715"/>
        <property type="gene ID" value="NSJP_3548"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3548"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="5">
        <location>
            <begin position="6"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="197" mass="22045" checksum="8792AF02AEB8876C" modified="2017-06-07" version="1">MRITKVYTRTGDAGQTRLAGGQQVWKDSLRVEAYGTVDELNASVGLVRAMNDESSGATDSARQLEEDLRWIQNKLFDLGSILATAPGQSFKNMPTITAPDVVRLERMIDRCQKDLAPLKEFILPGGGKVSATLHQARTICRRAERIGVRLAKEEAVDPQMNKFLNRLSDALFVLARWAAKQRGEPEFLWQRNADETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Y6</accession>
    <name>A0A1W1I9Y6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="7">3-dehydroquinase</shortName>
            <ecNumber evidence="5 7">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">aroQ</name>
        <name evidence="9" type="ORF">NSJP_3416</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5 7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3416"/>
    <dbReference type="EnsemblBacteria" id="SLM49583">
        <property type="protein sequence ID" value="SLM49583"/>
        <property type="gene ID" value="NSJP_3416"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3416"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="123"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="188" mass="20349" checksum="E22EBAAC5512FD8B" modified="2017-06-07" version="1">MPPCRSPVKAACRALHPTTELFMLRILVLHGPNLNLLGTREQGIYGSVALDAIDGDIVKLAEELSVEVDIRQSNHEGELVSWIQEARSGCHGVIINPAAYTHTSVAIRDALSAVSLPTIEVHLSNIHQREDFRHQSYVAGVALGQISGLGPAGYLLALRGLHGHLTARPPRTQPSSKAATSHRRTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA08</accession>
    <name>A0A1W1IA08_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49751">
        <property type="protein sequence ID" value="SLM49751"/>
        <property type="gene ID" value="NSJP_3584"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3584"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="1">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="155" mass="17476" checksum="7D0F9F6555349D35" modified="2017-06-07" version="1">MITQMHLKGLMFDPYNNAYIVVLRDEDGSEMLPIWVGKSEANSISMALENVGPPRPMTHDFMKSFLDAYDAKLLSVVITDLADHTYFAKIHLMYGDSEYTVDARPSDAIALALRSQAPIFAKESVLTKQSSEELEQWLENLKPEDFGKLDSGEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA48</accession>
    <name>A0A1W1IA48_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49928">
        <property type="protein sequence ID" value="SLM49928"/>
        <property type="gene ID" value="NSJP_3761"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3761"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="12"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="130" mass="13945" checksum="0626BD2AAE935A97" modified="2017-06-07" version="1">MCEDSGEGTVLAVHFSTSAAALLRPHSTGLDRELFIVVGLDAKHRVIGINLVSIGSLTLAIVHPREVFKPLILMNASVWLCAHNHPSGDVTPSLEDRTLTKRLREAADLLGMVPVGSSQSHWSGEIQLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA52</accession>
    <name>A0A1W1IA52_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3624"/>
    <dbReference type="EnsemblBacteria" id="SLM49791">
        <property type="protein sequence ID" value="SLM49791"/>
        <property type="gene ID" value="NSJP_3624"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3624"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="2">
        <location>
            <begin position="18"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="237" mass="27123" checksum="1551742F5A485869" modified="2017-06-07" version="1">MVVAILSASMPRIPRGQVGGYAYHVLNRGNGGTAVFHKDGDYSAFFALLARAREKFPVKVLSVCVMPNHFHVVVQPAAEAVLSSSMQWWMTSHVRRYHRHYRTHGHVWQGRFKSFPIQQDAHLLTVMRYVLRNPVRSGLADCVMDWPWSSLRFPQLSDPIPIETPKNWLEWIDQPLFEHELTKLRLCVNRQQRFGEEAWQTATAAALGLESTLRRRGRPSKTAEKKPVPYLGPVSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAK4</accession>
    <name>A0A1W1IAK4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative HTH-type transcriptional regulator, rrf2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3869"/>
    <dbReference type="EnsemblBacteria" id="SLM50036">
        <property type="protein sequence ID" value="SLM50036"/>
        <property type="gene ID" value="NSJP_3869"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3869"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="144" mass="15763" checksum="AC1D350EF6529727" modified="2017-06-07" version="1">MKLSKKSEYGLRALLELTLANGSKTLQRHEIADRQGIPVEFLEQILLALKRAGLLSSRRGVRGGYVLIKPPSQITLGQVIRILDGPLAPIGCVSKTAYQKCSDCPYAEKPRCPVQHVMGTVRDAIADILDNYTLEDFSAGQQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAL1</accession>
    <name>A0A1W1IAL1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Riboflavin biosynthesis protein RibD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Diaminohydroxyphosphoribosylaminopyrimidine deaminase</fullName>
                <shortName evidence="7">DRAP deaminase</shortName>
                <ecNumber evidence="7">3.5.4.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Riboflavin-specific deaminase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
                <ecNumber evidence="7">1.1.1.193</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">HTP reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="primary">ribD</name>
        <name evidence="12" type="ORF">NSJP_3863</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17845"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58421"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="EC" id="1.1.1.193"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 10">Binds 1 zinc ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">In the C-terminal section; belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.26" evidence="7"/>
    <dbReference type="EC" id="1.1.1.193" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3863"/>
    <dbReference type="EnsemblBacteria" id="SLM50030">
        <property type="protein sequence ID" value="SLM50030"/>
        <property type="gene ID" value="NSJP_3863"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3863"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011549">
        <property type="entry name" value="RibD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006769">
        <property type="entry name" value="RibD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00227">
        <property type="entry name" value="ribD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="11">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="307"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM50030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="373" mass="39742" checksum="179B3E2E54A815DB" modified="2017-06-07" version="1">MRVNPADDDRYMSLALRLAEKGRGTTSPNPMAGAVVVRRGRIVGRGFHLRPGLPHAEILALLEAGPLSEGADLYITLEPCCHTKKRTPPCVPAVLDSNLRRVIVATTDPNPLVDGKGVAALRRAGLPVTLGVKEREAQALNRTYSHWVTARRPYVILKAGMTLDGQIATSTGRSRWITGMPSRRDAHRLRTQVDAVLVGVGTVLKDDPSLIARTGPRLLAPADRQALRVVVDSTLRVPPGAHVLSEQETAKTLVATTTAASVSRRRALEQLGIEILILPSAEKQVSLPALLRALGHRGITSVLVEGGGEINASLLRGKLIDHVCLYVAPMLLGGADAMGLIGGRGPVRLASASGLRGMKIRSLGEDFLVEGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAP1</accession>
    <name>A0A1W1IAP1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49959">
        <property type="protein sequence ID" value="SLM49959"/>
        <property type="gene ID" value="NSJP_3792"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3792"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10941">
        <property type="entry name" value="CE4_PuuE_HpPgdA_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045235">
        <property type="entry name" value="CE4_PuuE_HpPgdA-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022560">
        <property type="entry name" value="DUF3473"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11959">
        <property type="entry name" value="DUF3473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="22"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="301" mass="34259" checksum="338010B6211B459F" modified="2017-06-07" version="1">MRKTLTCGPPVISIDVEDWPQSTWNRDLPITDRAVGNTRRVLRILRNANVRATMFILGKLAERFPYLVKEIQADGHEVACHGYGHMEIAQLSPDEFLADVRRSKDLLEQITGEPVVGYRAPDFSIVENTLWAFDALAEAGFQYDSSVVPVRVVRYGIPDWPGAPVRVKLANGRTIQEAPLATFQMLGKNWPVGGGGYHRLLPGFLTRSLARQVMKTAPFVFYCHPYEFDVWELEEIPISLPLSVRWHQGAGRRYFERRFNSFVHEFGGQRMQDMLASQVWPEFELPSVNRGSIRKRTSGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAS6</accession>
    <name>A0A1W1IAS6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-24 (FecI-like)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50085">
        <property type="protein sequence ID" value="SLM50085"/>
        <property type="gene ID" value="NSJP_3918"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3918"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="108"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="168" mass="18779" checksum="983BAB892192ACD8" modified="2017-06-07" version="1">MLEQLFVTHRHTLVSTIARMVGCRHTAEDLAHEAYLRVSQALDARPILNLQNFLYQTARNLAIDYIRRERLRRGFMNDAAEADTLTAVPSAQPSPETQTMDGQRLALFDAALSTLPVRARRMLLLNKIQGLGYPEIAAQLGVSESTVYNDIRFAVAHCLAAMVEKDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAY2</accession>
    <name>A0A1W1IAY2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pepP</name>
        <name evidence="5" type="ORF">NSJP_3892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3892"/>
    <dbReference type="EnsemblBacteria" id="SLM50059">
        <property type="protein sequence ID" value="SLM50059"/>
        <property type="gene ID" value="NSJP_3892"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3892"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="144"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM50059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="381" mass="42211" checksum="EF02751881F05CD2" modified="2017-06-07" version="1">MSRSASQSHKAVVFIAASETDANLYYATRFIAPDPFIYLEIKGERLLVMNDLEIDRAKSQASVDRVLSYTEIEQRARDQGVASPGSADIVHVVLRDAKIKQVLVPGNFPFRHATRLQELGYQVHAKPDPFYEQRVVKTAEEVRHIEEAQRATEAAVAAAHAVLRRATIVKNELWFEDSPLTSERVKKLINVKLMEADCVAQHTIVAGGEQACDPHNEGSGPLPANRSIIFDVFPRSATTRYFADMSRTVVRGTPSPELVRLYQTVKDAQEEAITKIKDGADGMRIHRGICDRFEKAGYKTGLVNGRMQGYFHGTGHGVGLDIHEAPRISRTGSLLQEGHVVTVEPGLYYPGLGAVRIEDMVLVTSDGCRNLTDFPKTFELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAZ2</accession>
    <name>A0A1W1IAZ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4017"/>
    <dbReference type="EnsemblBacteria" id="SLM50184">
        <property type="protein sequence ID" value="SLM50184"/>
        <property type="gene ID" value="NSJP_4017"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4017"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="2"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="51" mass="5829" checksum="CFDEA1DA9489A0C6" modified="2017-06-07" version="1">MFESLEQVREISAKWLQSYNEERPHDALAGLPPAIYRAQLERGSSPLTVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB44</accession>
    <name>A0A1W1IB44_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_4059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4059"/>
    <dbReference type="EnsemblBacteria" id="SLM50226">
        <property type="protein sequence ID" value="SLM50226"/>
        <property type="gene ID" value="NSJP_4059"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4059"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013630">
        <property type="entry name" value="Methyltransf_Zn-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038576">
        <property type="entry name" value="Methyltransf_Zn-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013691">
        <property type="entry name" value="MeTrfase_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08421">
        <property type="entry name" value="Methyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08484">
        <property type="entry name" value="Methyltransf_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_13" evidence="1">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_14" evidence="2">
        <location>
            <begin position="246"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="411" mass="46286" checksum="FFE42AD4571A4D59" modified="2017-06-07" version="1">MKQSLCRSCGAAIEHTFVDLGMSPLANSYVKPEQRNRMEPFYPLHVYVCAKCWLVQLEQFTSPHDIFSDYAYFSSFSDSWLAHAKAYVEMIAARFNLNSCSKVVEIASNDGYLLQNFVARKIPVLGVEPAGNVAEVAKGKGINTKVAFFGEKTALDLKSEGWTADLIIGNNVLAHVPDLNDFVKGLKILLKPTGAVTMEFPHLLRLMDQNQFDTIYHEHFSYFSFLAVEQVFARHDLALFDVEELPTHGGSLRIYGRHSEDGSKPTTDRARELKAREVAGGFNRLSHYLTFGPQVEATKRKLLSFLIEARQEGKTIAGYGAPAKGNTLLNYCGVRTDLVAYTVDRSPHKQGHYLPGVRIPIYSPDQIKLTRPNYVLILPWNLRDEIMEQMAFVREWGGKFVVPIPEVKVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBE0</accession>
    <name>A0A1W1IBE0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_4042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4042"/>
    <dbReference type="EnsemblBacteria" id="SLM50209">
        <property type="protein sequence ID" value="SLM50209"/>
        <property type="gene ID" value="NSJP_4042"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4042"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="334" mass="38326" checksum="F10D39EA19735E5F" modified="2017-06-07" version="1">MFEPLVSVIIPTYNSQDYIREAVDTVLKQTYANLEIIIVDSSTDDTKQALERYGEKVRYFYQEPKGVSAARNFGLRQARGSLVAFQDADDRWLPGRIEAQILALRHFPDAALVFSDYAMFDHSGVILPSACWPHFKIWLEEHRVTEGDLAYGQLYWELMLGNCIGTCAVLAAKDVLEEFGGFDETFKTCEDLDLWLRVSTKHSFLYIDKVLAEYRVHSSGLSGAQDTRDMTWALDRARVREKHLRADLVPQDLRSRVERLQGKDCWELGIACLDRGDRPLARTLFSMGLRYRPFDILTWLYIGFSLLPNSFIAIGKRMKRGIHQGPAWSSEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBI8</accession>
    <name>A0A1W1IBI8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50133">
        <property type="protein sequence ID" value="SLM50133"/>
        <property type="gene ID" value="NSJP_3966"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3966"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="85" mass="9189" checksum="8B0DED87B3969809" modified="2017-06-07" version="1">MSFYAHSSRQHGWPQIGESFALCLLTVLEMKKPNATPTGDLGLCTQSALASATTTSRHVAYTAMNLIISISTRFSKAPSSRGRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IC04</accession>
    <name>A0A1W1IC04_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_4136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50303">
        <property type="protein sequence ID" value="SLM50303"/>
        <property type="gene ID" value="NSJP_4136"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4136"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="292" mass="33273" checksum="752E44AEF4C70CC4" modified="2017-06-07" version="1">MADNTRHSFKDKWENNPHLALDQTLEEGSDINRWILTRNGFASKAELAAYLATKRRILDAGCGNGRVTALLRSCSPVDHTDIVAFDLVAADVARRNLAGYERIDVREADLLGDLSGLGRFDFIYCQEVLHHTSDPEKAFRNLCSLLEPGGEIAVYVYKQKAPVREFVDDFVRARISGLSYEDAMKTAEQITALGKVLSELRTDVDVPAVEALGIPAGRYDLQRFLYHFFMKCFWNPELSFHDNAVINYEWYHPQLCSRHTVEEIRAWFDRAGLRVLHEHVDFYGITMRGRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZH8</accession>
    <name>A0A1W1HZH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Lipopolysaccharide heptosyltransferase II</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0008"/>
    <dbReference type="EnsemblBacteria" id="SLM46180">
        <property type="protein sequence ID" value="SLM46180"/>
        <property type="gene ID" value="NSJP_0008"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0008"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="342" mass="36887" checksum="6AA2A8AFEC97E5D8" modified="2017-06-07" version="1">MKAYQHILFIKPSSLGDIVHAMPALAAVRRAHPGATVGWLVKRQWAGLVERIDGVDHLWEVEPGVKGWLSLVPALRADRFDLAIDLQGLFRSAAMARLSGVPERIGFANAREGSPWFYTRHVPVPHPNMHAVDRYLLVAKALGADEHPAEFKFRIPHRDHETVDRALKQAGWTAGERFVAVNVSARWPTKRWPVASFAALSDLIVQRGIGSVLFIGGPNERAEVAQVKALMKARSLDLCGALPVGLLPALLGRADLLVTNDSGPMHVAAAVGTPVAAMFGPTSPLCTGPYGAGHGVLMHPVPCSPCFSRTCSNSKHLACLTDITVDRAFSVVASLPRRSAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZP6</accession>
    <name>A0A1W1HZP6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rplS</name>
        <name evidence="8" type="ORF">NSJP_0058</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0058"/>
    <dbReference type="EnsemblBacteria" id="SLM46230">
        <property type="protein sequence ID" value="SLM46230"/>
        <property type="gene ID" value="NSJP_0058"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0058"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="143" mass="16077" checksum="AC84FB9732B6A480" modified="2017-06-07" version="1">MNQLERVQRSLTKKSMPHFEIGDTVRVHVKVIEGEKERIQVYEGAVIARKGTLNTEMFTVRKVSYGVGVERIFPVHSPIVTKIDVMRQGKVRRAKLYYLRGKKGKFSRVEDREFVAESKAQAPAARAEEPAGAKVESASPAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I052</accession>
    <name>A0A1W1I052_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0204"/>
    <dbReference type="EnsemblBacteria" id="SLM46376">
        <property type="protein sequence ID" value="SLM46376"/>
        <property type="gene ID" value="NSJP_0204"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0204"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="384" mass="43206" checksum="B92BA3296B657357" modified="2017-06-07" version="1">MGRAGVIPVVMALLLGLPLLGVWLAGKPLWPYLEFPPRTILAVHAPFSWMAFLAVGLSIGLTVGPILYQVLTSHSRFRHATRATHDSALGTQHRHVPWWGWAGIAWTITWWLLAWTRFAWMTSIQEHTFTPLWLGYVVTVNAWTVFRTGRCLLLNRPRFLLALFPLSAGFWWLFEYLNRFVQNWYYVGIDELSPLSYVLRGTVSFSTVLPAVACTAGLLASFPCLTAGLDRFWAIPVRHTGALAWSGLAVSCAGLLCIGLWPDSLFALVWIAPLLLAVSLQAVYGESTILSPIMQGDWRLPWLYGLAALVCGIWWELWNWGSLAKWQYTVPFVHRFQVFEMPLLGYAGYLPFGLECLVVIHWWSQHSGSAESAISALHRVDSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I074</accession>
    <name>A0A1W1I074_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0219"/>
    <dbReference type="EnsemblBacteria" id="SLM46391">
        <property type="protein sequence ID" value="SLM46391"/>
        <property type="gene ID" value="NSJP_0219"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0219"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="320" mass="34016" checksum="DED40086F002A23F" modified="2017-06-07" version="1">MDSVLSGVASPTDFSFSVKRPDGRQYVYSRGASTLQTSYSSASTSKLVSAVIIMRLVEQGRLSLASKPQDLIGTWPIGGGDPLLNMTLAQLLSFTSGLTIEPSCLDDGTSEYEACVTTIGTANGGTGITPGQQFFYASTHLQVAGLMAIKARPAATWQDVFLEFKQQTNLFPTASYDSPSPNNPALAGGMHWTGEEYLAFLDALRKGELLNAGSMGQLLADHTASAAIVSSPIAVAPPDGLGEDWHYGFGLWHECQSANFNCTPGTRVSSPGIYGAYPFWDRSKGYVGIVAMQGPSNSIPIGIGIERSVRPTVEQWVACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I087</accession>
    <name>A0A1W1I087_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46392">
        <property type="protein sequence ID" value="SLM46392"/>
        <property type="gene ID" value="NSJP_0220"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0220"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018550">
        <property type="entry name" value="Lipid-A_deacylase-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09411">
        <property type="entry name" value="PagL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="229" mass="24860" checksum="73389A8A59D6E963" modified="2017-06-07" version="1">MGILPILMKTMLRLFSTGLITAFRGLIFFTKGDSMGRVRIGARLCPGALIGLMIFMAATSAIAEGFRLESLNVRAGLSGSSVIGKDQQTDFNQVDLALAARLPWEWSVGSDWLFATRALTSAGALHGSGETHAVFTLVPFDVMFGRRDGLISIDMGVGGALLTDSKFGDQNFGGPFQFVWTFGATSRLFGPLGVGYHFQHYSDATMYGPDSRGVDLHLLELIYWFDTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I099</accession>
    <name>A0A1W1I099_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0225"/>
    <dbReference type="EnsemblBacteria" id="SLM46397">
        <property type="protein sequence ID" value="SLM46397"/>
        <property type="gene ID" value="NSJP_0225"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0225"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025961">
        <property type="entry name" value="Metal_resist"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13801">
        <property type="entry name" value="Metal_resist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012845469" evidence="2">
        <location>
            <begin position="29"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="206" mass="22204" checksum="6DFEA25840E9C7AA" modified="2017-06-07" version="1">MKKGIRNVMTLGAASAFTLALATSGVWANEPGYGKDGHGGGEHGGMRGHGMGMMHSSAGHLIRHLLKHEKEIGLTPDQVTKLKEIQLNLDKTRIKSEADIQVAEREIKALTDNEKSDLGAIEAKLKQSEDLQVALRMTSIKTRREVLALLTPEQRQKEQAEHEKMMQQHKEGGKDGKNPHGGGMGNPHGGMTPGHPPKAADAPPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0G6</accession>
    <name>A0A1W1I0G6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0309"/>
    <dbReference type="EnsemblBacteria" id="SLM46481">
        <property type="protein sequence ID" value="SLM46481"/>
        <property type="gene ID" value="NSJP_0309"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0309"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13463">
        <property type="entry name" value="HTH_27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="46"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="235" mass="25667" checksum="13BCFF9B084512A0" modified="2017-06-07" version="1">MSELHMIDPAAQPSSEATPTPSEPMVVQLASGFEKIGLAMKSRSWRREGRPGLGPLQRQILTLLRSKPGRTAQVSTIANELVVRLPTASEAVATLERKRLVRRRRTMQDGRVVTVELTARGLRACGPTAGAPDHLTMAIGLLPAAEQASLLKALVKVIRTLQNKGEISVARMCVSCRYFQPNRYPDPDRPHHCSYVNAPFGDVSLRLDCGEYEAAVPDQARDAWALFAGEQTATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0P5</accession>
    <name>A0A1W1I0P5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0389"/>
    <dbReference type="EnsemblBacteria" id="SLM46561">
        <property type="protein sequence ID" value="SLM46561"/>
        <property type="gene ID" value="NSJP_0389"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0389"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="338" mass="38706" checksum="00C531EC4E27FA3A" modified="2017-06-07" version="1">MQQDVGRSEMDPFVSVIISAYNLGWCIEDTIRSVLAQTYQDFEVIVVDDASTDDTETRVAGFGDRIRYVRHASNQGTVRNAEGAPTRNTGVRHSRGELLAFLDGDDLWEPEKLAVQIEAARRYPDAGMIAVDGIQFNSSNGMIITPTLFNGIVKEYETLPYGAMLSASLYLPMLHHCLIETPSQVIIPKQVLDRVGLFHEGGGSSDYDMFIRVAARFPIILIKQSLVRYRYQPSSWSGQIDRRRFKHFEPNIAIWSRHLGIADEETQPVIRRRIAQELYEVTTSAFEDGRNGHRAWALSFLFGQFRRRPSWRTAYLFFRLWCPQRLEAALKPVIRRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Y2</accession>
    <name>A0A1W1I0Y2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Cell division protein ZapA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0483"/>
    <dbReference type="EnsemblBacteria" id="SLM46655">
        <property type="protein sequence ID" value="SLM46655"/>
        <property type="gene ID" value="NSJP_0483"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0483"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007838">
        <property type="entry name" value="Cell_div_ZapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036192">
        <property type="entry name" value="Cell_div_ZapA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34981">
        <property type="entry name" value="PTHR34981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05164">
        <property type="entry name" value="ZapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102829">
        <property type="entry name" value="SSF102829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="98" mass="11280" checksum="D00807EDCC1B4347" modified="2017-06-07" version="1">MTKTTYVEIYGQRYAIRGEADEDYIRRLASFVDGQMRHLAEGLNTTTPSKLAVLTAVNLAHQLFEAEKKRTEGEEVVERRMITLMESIEEQVPTSLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Z7</accession>
    <name>A0A1W1I0Z7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46539">
        <property type="protein sequence ID" value="SLM46539"/>
        <property type="gene ID" value="NSJP_0367"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0367"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="2">
        <location>
            <begin position="74"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="394" mass="42888" checksum="0FFA772D108E3E4B" modified="2017-06-07" version="1">MMKMLTGRYIAVALGLLFVAYIGYRIHESRSDAALLREKTVEDAVPTVAVVHPKPGDPSETITLPGNITAWFEAPIYAQVSGYVKMWYKDYGAQVKKGDILAEINAPALDAQYAQAKADLESERAKYALADITAKRWLALRKNHAVSEQSISVQVAHAKAEAAKVKAAEQNVRNFEALIRFKTIVAPYDGVVTVRNINVGDYVNKEGTISTPVSISNLFTVADVSMMRLFVSVPESFGPFLQPGLTADVTVPQLPTRHFIGKFLTVARGFDVNTRTAVTVFTIENEDRALWPGSYGKVVLTAPVDRKVFMIPSTALVFQEHGTQVAVVKDDDRVHMQPITVSRLLDSAVEVSDGISANDRVVNNPSAALLDGDKVRVVKPAAGYDLISGESAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I158</accession>
    <name>A0A1W1I158_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enoyl-CoA hydratase</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fadB</name>
        <name evidence="2" type="ORF">NSJP_0555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0555"/>
    <dbReference type="EnsemblBacteria" id="SLM46727">
        <property type="protein sequence ID" value="SLM46727"/>
        <property type="gene ID" value="NSJP_0555"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0555"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="260" mass="27715" checksum="D8247F1DCC6FED74" modified="2017-06-07" version="1">MSHQLLLTVSHHVARITLHNPPANVLNLSMLKQLEHVLSEVEEDEFVRVMIVTGSGRFFCAGADLNELAHLNTMHGGAEFAVRGQSLLNRIERSEKPVLAALNGTSVGGGLELALACHIRLAAAGIMMGLPEVKLGLIPGFGGTQRLPRVVGASRAAEMILTGESLSAEEGQRIGLVSRVVPQHELMAQAEAVATVISSRGKPAIEAALHAIRGGLDIPLSEGLDREAELFGRLCATDDKRAAVQAFLEKRHSRLTEANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I183</accession>
    <name>A0A1W1I183_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2Fe-2S ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fdxB</name>
        <name evidence="3" type="ORF">NSJP_0569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0569"/>
    <dbReference type="EnsemblBacteria" id="SLM46741">
        <property type="protein sequence ID" value="SLM46741"/>
        <property type="gene ID" value="NSJP_0569"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0569"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="PTHR23426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="138" mass="14691" checksum="46C2958548909778" modified="2017-06-07" version="1">MGGTNPYIEKSDVDLPTRPYTVTFVAPNGEVTKVQVDPNKIPYGMTGLPGSLLDIAMGNGIELEHVCGGVCACSTCHVIVKQGLESCNEGTDDEFDQLDEAPMTTLQSRLGCQCVPNGTKDIVVEIPAVNKNLVKEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1M1</accession>
    <name>A0A1W1I1M1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_0712</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0712"/>
    <dbReference type="EnsemblBacteria" id="SLM46884">
        <property type="protein sequence ID" value="SLM46884"/>
        <property type="gene ID" value="NSJP_0712"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0712"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="473" mass="53721" checksum="B8DB61EFC66F88DB" modified="2017-06-07" version="1">MLQDADALPQLIGDYKPVDQWQVHINHLFYKFRSDFIRNYYQTFASADYRLAHALASDYFERVVKRDASPSSAGKDSSPLTVMEWGPGNGNLAACFLSHLRTLDNQGQVYPRIRYVMVDWEPSLLDRAVASPSLVQHRDRIEPLCTTVDRISDIADGTVDRIICNELWNDLPAKLMCRQGGDMEEEFLRPNLSDTLHAKIDDWAAFVRAFDAKDVETLRRFPPFFDDLVWEREYRTVDWKDVPYRKTITEFLRRFDEQIVVPVNIGAFVTLKEATRLLAPDAAGFSSFDAGSTDLKVLNDPDKPCSGQFGGQQSYMVNFPLVEAVAKQLKAGRVAVESQREFIGRSLGTNVLTLMDLLATHPLAGTRMEPWEQDRLLLRTIRAFDEVYESPYERKMEFSLRADTPAAERDALQAMADGLKATGVPDTVAYLTEEELTAASRNLEEIGYDPHSFLIALTAPPSPVDYFHLSMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1N1</accession>
    <name>A0A1W1I1N1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0725"/>
    <dbReference type="EnsemblBacteria" id="SLM46897">
        <property type="protein sequence ID" value="SLM46897"/>
        <property type="gene ID" value="NSJP_0725"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0725"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="309" mass="33246" checksum="744A79DCF1A16D7A" modified="2017-06-07" version="1">MYRILGGLTIGVLLLDLGCTSEERYAGSTAAGNDPPSMHSITIVPNPIIRHGIVTAVAETQDPNQDEVAVRFRWFVNGAEASGESSATLSPMRLKRGDRVSVEATPHDGKVAGSSLRSSEVLVGNTPPIIQTVALEPQEPKVGEIIHAELEGADLDGDAVKYNYTWRRNDQVVVTGEQNVLDSAGFSRGDTVSVWVTPHDQGGEGKEARSPSVTISNRPPKFTSLASPVVAEGEFQYQVSANDPENDPVTFSLDSAPPGMTINEKTGQLRWSIPPSAQGVFRVKVMARDDHQGWAFQEFDISPKAQAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1S2</accession>
    <name>A0A1W1I1S2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46960">
        <property type="protein sequence ID" value="SLM46960"/>
        <property type="gene ID" value="NSJP_0788"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0788"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="188" mass="20791" checksum="6021DAA156EC51AE" modified="2017-06-07" version="1">MARPMRWSPRPGSAHLVGIVSLAFFSIIWSEKPPEAAAPDQDDVRSHAEQSFSRLPPATGAAPSHRDQGAAYPPDQYLIGTGQGDMAKGTSVCRRVSELSARTEIAKQIRILVKEHMVDRVRERNGRETDQDIELTREEIVQEYLQGVMIVDRQVDEAAHTCSATAVMSKKYLQVSPTQPDSSPALVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I213</accession>
    <name>A0A1W1I213_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0884"/>
    <dbReference type="EnsemblBacteria" id="SLM47056">
        <property type="protein sequence ID" value="SLM47056"/>
        <property type="gene ID" value="NSJP_0884"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0884"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="192"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="455" mass="49498" checksum="3C08E7D346A50F92" modified="2017-06-07" version="1">MNLKAALERYVPDRRAQFEDLLGHMVEIPSISMDPARAGDIRRMATMAVDVLNGLDAKARIVETGGYPIVSGGWMTGARYPTVTIYNHMDVQPAQEAEWKRDPFAFANENGIYRGRGATDDKGPALSALFGARLAVEQGVPINIRFLWELEEEIGSPHFAAGLKDREGIPCPDSVVVSDTIWIAKGRPAAPYGLRGLIGARLSLRTGSKDAHSGVTGGAARNPLAELMDVAMACVNAKTGEVKIPGFYKDVVPPTKAEVASFLKSGFEVKRFKEAYGFHSLRTEAPAEVTRRIWAAPTFEVHGLTGGYHGPGIKTIVPGQAELKVSMRLVPNQAPERIFALLKAHVRTLNPNVRVEPEGMLHPFKGSFEGPYIDCVKRAAKAGFGKEPAFIREGGSIGAVVTMQKMWKVPILFLGLSLPEHGYHAPNEYFDWGQASGGMKAFAHYFAEVAKMKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I228</accession>
    <name>A0A1W1I228_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47066">
        <property type="protein sequence ID" value="SLM47066"/>
        <property type="gene ID" value="NSJP_0894"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0894"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043462">
        <property type="term" value="P:regulation of ATP-dependent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011726">
        <property type="entry name" value="KdpF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09604">
        <property type="entry name" value="Potass_KdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02115">
        <property type="entry name" value="potass_kdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="29" mass="3254" checksum="25F7F5AA7E45439A" modified="2017-06-07" version="1">MALMYWIGAILSTAALIYLLVALLKPEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2C3</accession>
    <name>A0A1W1I2C3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47144">
        <property type="protein sequence ID" value="SLM47144"/>
        <property type="gene ID" value="NSJP_0972"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0972"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="60" mass="7015" checksum="84BC4E014303CC8E" modified="2017-06-07" version="1">MFGAADNGDIRAPKDVWMTANRMNIRDMRRIVGTPGQTRKGQKLLYLSTNFVRKRMCRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2H3</accession>
    <name>A0A1W1I2H3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Coenzyme PQQ synthesis protein B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Pyrroloquinoline quinone biosynthesis protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">pqqB</name>
        <name evidence="8" type="ORF">NSJP_1022</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May be involved in the transport of PQQ or its precursor to the periplasm.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PqqB family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1022"/>
    <dbReference type="EnsemblBacteria" id="SLM47194">
        <property type="protein sequence ID" value="SLM47194"/>
        <property type="gene ID" value="NSJP_1022"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1022"/>
    <dbReference type="UniPathway" id="UPA00539"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018189">
        <property type="term" value="P:pyrroloquinoline quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00653">
        <property type="entry name" value="PQQ_syn_PqqB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011842">
        <property type="entry name" value="PQQ_synth_PqqB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02108">
        <property type="entry name" value="PQQ_syn_pqqB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0884">PQQ biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Lactamase_B" evidence="7">
        <location>
            <begin position="51"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="307" mass="33303" checksum="FB91389C283B9CE6" modified="2017-06-07" version="1">MILRILGSAAGGGFPQWNCACTNCSGLRQGLIVASPRTQESSCLSVDGRAWFLINASPDIRVQIESFGPLHPAIGRATPIEAIFLTNGDLDHCLGLLSLRESQPVVIYATDTVRRGFTEGNVLYRTLERFPGQVTWRRLVLGEEDAVRHANGVPSGLAVTAFAVPGKPPVHLDGMVDREQPELNVGLRFRNVENGRVLAYVSSVGRITEAVLEGLAGAEGILFDGTFWSSDELSGPGFLRKSAEELAHCPIGGMDGSLARLTGLPARHRIFIHMNNTNPILREDARERTMVEASGWQVGRDGMEIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2H5</accession>
    <name>A0A1W1I2H5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PqqA peptide cyclase</fullName>
            <ecNumber evidence="7">1.21.98.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Coenzyme PQQ synthesis protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pqqE</name>
        <name evidence="9" type="ORF">NSJP_1025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[PQQ precursor protein] + S-adenosyl-L-methionine = 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:56836"/>
            <dbReference type="Rhea" id="RHEA-COMP:14800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:141026"/>
            <dbReference type="ChEBI" id="CHEBI:141027"/>
            <dbReference type="EC" id="1.21.98.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with PqqD. The interaction is necessary for activity of PqqE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the radical SAM superfamily. PqqE family.</text>
    </comment>
    <dbReference type="EC" id="1.21.98.4" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1025"/>
    <dbReference type="EnsemblBacteria" id="SLM47197">
        <property type="protein sequence ID" value="SLM47197"/>
        <property type="gene ID" value="NSJP_1025"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1025"/>
    <dbReference type="UniPathway" id="UPA00539"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009975">
        <property type="term" value="F:cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018189">
        <property type="term" value="P:pyrroloquinoline quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00660">
        <property type="entry name" value="PqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011843">
        <property type="entry name" value="PQQ_synth_PqqE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00280">
        <property type="entry name" value="coenzyme_PQQ_synthesis_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02109">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 7" id="KW-0884">PQQ biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="4"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="366" mass="40955" checksum="8F6FE48714FA65DA" modified="2017-06-07" version="1">MTSPYRPYTLIAELTHRCPLRCPYCSNPVESPGPGIELDTETWLRVFDEADALGVVHVNLTGGEPLLREDLERLVERAAERDVYTNLITSGIPLTVERLRRLKAGGLNSVQVSVQGARQPGADVIAGGSFFNRKLEVMRWVKAVGLPLTMNVVLHRENLDEIEDVIRLAERMEADRLELANTQYLGWALHNRTALLPTREQIERARAVATEAKRRLRGTMDVCFVLPDYYADRPKACMDGWGRRYLVVNPEGLVLPCHLAHTLPGLSFDNVRQRSLTEIWDASAGFNRFRGEEWLPDPCRSCPSRSEDFGGCRCQAYHVTGKADAADPACALAPDHRLIEAARTGAVQSGTPVVFAYRELRRSVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2H9</accession>
    <name>A0A1W1I2H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47208">
        <property type="protein sequence ID" value="SLM47208"/>
        <property type="gene ID" value="NSJP_1036"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1036"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="83" mass="9185" checksum="6134BF1203E74BD1" modified="2017-06-07" version="1">MRRLLEWSNGKPPVRWMNTSGDRKGAAYATFSLVDEYPVGVPGDRSDPCPAEAPARQKIGRIEDQSSDPANVTNGVYCHDIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2L8</accession>
    <name>A0A1W1I2L8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47119">
        <property type="protein sequence ID" value="SLM47119"/>
        <property type="gene ID" value="NSJP_0947"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0947"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="169" mass="18408" checksum="EC1A5D6F46534A5A" modified="2017-06-07" version="1">MTGILRSLAWIRCSNSMPLIPGSRTSVITRSIRLSSRTFNAPSARAAITKSTCSSASRGSSASTVRRKTSTSPPLSSTSRMVKILSVTGLMLIAFRWVLVSQLLGYHRRAAVLQQRMSGRHFTKGFDRIKMREEGRGKKERGGAESKGIAEIVTAEFYGNIISPPTFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2N0</accession>
    <name>A0A1W1I2N0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47139">
        <property type="protein sequence ID" value="SLM47139"/>
        <property type="gene ID" value="NSJP_0967"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0967"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="106" mass="11939" checksum="FCCAC75A19AB25B5" modified="2017-06-07" version="1">MIQRKSPRFAVQLPIRFQDDTAEAGGTILNISHDGCMITASRTPDTATYLRLDLHLREGEPPVKVSLAAVRWASKSQFGLEYIKVGAEERERLKSFMTMLERSPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2W6</accession>
    <name>A0A1W1I2W6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1139"/>
    <dbReference type="EnsemblBacteria" id="SLM47311">
        <property type="protein sequence ID" value="SLM47311"/>
        <property type="gene ID" value="NSJP_1139"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1139"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="367" mass="41260" checksum="69669889AD84B632" modified="2017-06-07" version="1">MSRQSEGPRHPLSQAARSDADRISETSLHERPRPSAGCHVCHATQWTLVCSSGEIFSQRRQLERFYRRRWHAQPSGTSEDRWIFTQNYLTSIVACLECGLLYRNPRPRPEAITRAYLATRNDHESVRTEFETQGRWFRSKAGMLCGYLPVRSRTAPRVLEIGGGTGGFLAEGQALGWEMLDLDPDHALTDLGRRRGSATLQSTIEDAGWSGETFDAVTIWNSFGQLSDPHPLLNSVVPLIRSGGMLVIRIPNGACFEWAMALRAKLPKPWRRPLDAALAWNDLLTFPYLYGYSPVGLTSFMSSFGLTLRACHADTLPSVPAARLKWWAGLEERMVKGGCRTACAVSRQPVRGDFHLAPWLDVYFERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2X7</accession>
    <name>A0A1W1I2X7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47321">
        <property type="protein sequence ID" value="SLM47321"/>
        <property type="gene ID" value="NSJP_1149"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1149"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="60" mass="6834" checksum="B8DAA83C6518F887" modified="2017-06-07" version="1">MITLTTLVLFLCAMVMALYAFGFINAPSRGTFRTFQWTFYLLAVLTVLSVWFGITDEPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2X9</accession>
    <name>A0A1W1I2X9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">D,D-heptose 1,7-bisphosphate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gmhB</name>
        <name evidence="6" type="ORF">NSJP_1153</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GmhB family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1153"/>
    <dbReference type="EnsemblBacteria" id="SLM47325">
        <property type="protein sequence ID" value="SLM47325"/>
        <property type="gene ID" value="NSJP_1153"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1153"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004446">
        <property type="entry name" value="Heptose_bisP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42891">
        <property type="entry name" value="PTHR42891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="200" mass="22196" checksum="D6DBA2B76FFBF0B8" modified="2017-06-07" version="1">MIRAVFLDQGGALESPCYGTEPSRLMSDTFEGLRLLQRAGYAVVVVTHQGGVAKGFLGEPDVHRMKAYLEARLIEEDIPLGGFYYCPHHPDGKVRRYAVHCLCRKPQPGLLIRAASELRVDMGQSWMVGATLDDIETGRWAGCRTVLLTNGHETEWNLTEPRWPDYIAGTLLEASQLIALSSPRGVTQVPLDRLSRPPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Z8</accession>
    <name>A0A1W1I2Z8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to maltooligosyl trehalose synthase treY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">treY</name>
        <name evidence="2" type="ORF">NSJP_1200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1200"/>
    <dbReference type="EnsemblBacteria" id="SLM47372">
        <property type="protein sequence ID" value="SLM47372"/>
        <property type="gene ID" value="NSJP_1200"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1200"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11336">
        <property type="entry name" value="AmyAc_MTSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012767">
        <property type="entry name" value="Trehalose_TreY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02401">
        <property type="entry name" value="trehalose_TreY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="17"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="966" mass="110692" checksum="2E73F7072042F017" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I329</accession>
    <name>A0A1W1I329_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1203"/>
    <dbReference type="EnsemblBacteria" id="SLM47375">
        <property type="protein sequence ID" value="SLM47375"/>
        <property type="gene ID" value="NSJP_1203"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1203"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014004">
        <property type="entry name" value="Transpt-assoc_nodulatn_dom_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00749">
        <property type="entry name" value="BON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="190"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="268"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="339" mass="36810" checksum="BD9CB07FC699A3ED" modified="2017-06-07" version="1">MISRPVNAVNVIGRSRHLGALSGIIRKAGAVGWLAFLCFLVLSWDVARLDASDNNDDRSKDSGAAPESKKKPDSEAKPDAGAKPAAEEKAKEEKPRVEDKGKSDEKVKAEDKGRSEDRGKSEEKAKIDEKPKTEEKAKTEEKGKAEDKVKAEDKTKSEEKAKVEEKAKVEEKAKPEEPAQAKTEESGKKPVTSLNLTIKLALMGDPLLFPFDIEVEVDNRKAVLSGNVPTEEEKTRAAEIVKKIDGVDSVVNKLTPSPALRATLSKKQDETIAHLVRDRLARSETLKAVGFDVKAENGVVLLSGKTRFQVIALEAAEAARHIPGVRAVNTSGVQIIAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I347</accession>
    <name>A0A1W1I347_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47395">
        <property type="protein sequence ID" value="SLM47395"/>
        <property type="gene ID" value="NSJP_1223"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1223"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="118" mass="13731" checksum="F75ACAE5805E3448" modified="2017-06-07" version="1">MNIYEWGAIQAFRRGDREPLAKLLKERDLSMPLSKKLYEVFQELVDGKTGRAKGRPVVGDLCEQMYLAYLVGFHVRNGLRVKEALDKVSKERKRTFSYVERAHQKHRTVASLFFDPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I354</accession>
    <name>A0A1W1I354_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Acyl-CoA synthetase (NDP forming)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1091"/>
    <dbReference type="EnsemblBacteria" id="SLM47263">
        <property type="protein sequence ID" value="SLM47263"/>
        <property type="gene ID" value="NSJP_1091"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1091"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="86"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="755"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="974" mass="104418" checksum="DCA2783F13B6CE85" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3T8</accession>
    <name>A0A1W1I3T8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfate adenylyltransferase subunit 2</fullName>
            <ecNumber evidence="2">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-sulfurylase small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sulfate adenylate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cysD</name>
        <name evidence="7" type="ORF">NSJP_1463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1463"/>
    <dbReference type="EnsemblBacteria" id="SLM47635">
        <property type="protein sequence ID" value="SLM47635"/>
        <property type="gene ID" value="NSJP_1463"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1463"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019419">
        <property type="term" value="P:sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011784">
        <property type="entry name" value="SO4_adenylTrfase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002936">
        <property type="entry name" value="CysDAde_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="6">
        <location>
            <begin position="25"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="265" mass="30734" checksum="22519D31BEA200D6" modified="2017-06-07" version="1">MKHLRQLEDQSVYILREAYKHFDNLAMLWSMGKDSTVLLWLARKAFFGHVPFPLLHVDTSYKIPAMIEYRDRLAREWHLNLVVGQNKEALAAGMNHTLGRVTCCTALKTNGLKQLLEQKGYTGVILGVRADEEGTRAKERYFSPRDKHGDWDFRDQPPELWDQFKTTFPPGTHIRIHPLLDWTEINIWEYIKLENIPFIDLYLDKGDGTRYRSLGCAPCTMPIKSTAKNVDDIIEELRHTTVAERSGRAQDEGRGMELLRKDGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3U3</accession>
    <name>A0A1W1I3U3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G:T/U mismatch-specific DNA glycosylase</fullName>
            <ecNumber evidence="2">3.2.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mug</name>
        <name evidence="2" type="ORF">NSJP_1367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1367"/>
    <dbReference type="EnsemblBacteria" id="SLM47539">
        <property type="protein sequence ID" value="SLM47539"/>
        <property type="gene ID" value="NSJP_1367"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1367"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000700">
        <property type="term" value="F:mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="PTHR12159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="1">
        <location>
            <begin position="14"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="180" mass="19925" checksum="5EF6391D1591157D" modified="2017-06-07" version="1">MDKVSAPQTRLILPDYVRPGLRVLFVGINPGLRSAAIGHHFGGYSSRFWKLLFDAQLITEPLGPTQDFRLLEWGLGLTNVVARATAGIDALTARDYRLGAVRLLRLIRKNQPKIVAILGITPYRHIFRIPPGRPVDLGKQTVMLGTASIFVLPNPSGRNAHYPYGTMLESFCALRKAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3W5</accession>
    <name>A0A1W1I3W5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1387"/>
    <dbReference type="EnsemblBacteria" id="SLM47559">
        <property type="protein sequence ID" value="SLM47559"/>
        <property type="gene ID" value="NSJP_1387"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1387"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="213"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="378" mass="42694" checksum="9760A108B78ECB6D" modified="2017-06-07" version="1">MTRGFRHDWDLLRARLRLVATRRSIRLTPEGTRFLLFTVAIGVAAINTGNNLFYLLLALMLSLIVISGLLSEHCLRRLSFHRHVPDLIMAHDPATVSLSVTNRNSHLPSFSLRLFDVVGGSDVDRGLFIRQLSAQRSVLLSYPLLATKRGRIVLEQIRAETLFPFGLFLKRALYPIVTEVLVGPPIKPLSLRFIDDLVSEGQGRSLPRRGHGMQLYNLRLYRPGDDSRAIHWMTTARTAQLIIRETEAEDQRRITIALFCTAPDPLDDLFERSVTLVASLLWQLTQRNFPLRLLVGEEDSGSGVGSEHLLFMMRLLAVCRRRPPDQRHDGPDMTALSDSDSGYTLAVVPWTDPEKSRMTITADRIVEGAQIEDLTHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4B1</accession>
    <name>A0A1W1I4B1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1676</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1676"/>
    <dbReference type="EnsemblBacteria" id="SLM47848">
        <property type="protein sequence ID" value="SLM47848"/>
        <property type="gene ID" value="NSJP_1676"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1676"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="378"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="609" mass="66095" checksum="1049C25753810B70" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4B2</accession>
    <name>A0A1W1I4B2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47815">
        <property type="protein sequence ID" value="SLM47815"/>
        <property type="gene ID" value="NSJP_1643"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1643"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="102" mass="10614" checksum="A01BB3E173938899" modified="2017-06-07" version="1">MTRLLAPFAGAMTVLYLALTIGTAAYLSEPAAFSATAHHHSPSHVSHSALCVWACQANPAVAGLFVAPAKVVFTFLLLPPLLSLTVHSRISSPGSPSRAPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Q2</accession>
    <name>A0A1W1I4Q2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47984">
        <property type="protein sequence ID" value="SLM47984"/>
        <property type="gene ID" value="NSJP_1812"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1812"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012686949" evidence="1">
        <location>
            <begin position="25"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="222" mass="24353" checksum="4C853FC9ECC2B897" modified="2017-06-07" version="1">MIARALGIVVVCLLAMQPWETAQAFTVGPAEIELEPYAKGGTIAWDQLEGVGGHKSLVALGINALARFDRLGVGFNFENWWLGEKLDDDAGIIPNEGRRFYADLRYGFRPTEKLELYPFAGLGYEHWSRENAVNSWTSINFPYAAVGGGAEYEHCYAKIGVLMPFAATANVAPNPTSRIGVTADAGLRLFNFTVGVFFRSVGFEDPDAKMVQAGVMLGYRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4X1</accession>
    <name>A0A1W1I4X1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1905"/>
    <dbReference type="EnsemblBacteria" id="SLM48077">
        <property type="protein sequence ID" value="SLM48077"/>
        <property type="gene ID" value="NSJP_1905"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1905"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="242" mass="28022" checksum="7BA872D8B4D7365D" modified="2017-06-07" version="1">MKELRQTKLTFGLEPEVDLYRVSARLGFRDFRKTSCIVRSVTARDHHTCQFCGFRSAKYQQIVPVSEPLRDLNNLVTSCIFCEQVAHLNLVPQYRSGVLIWLPEVSQIELNRVMPAVYVCRITQGLGATKARSVLDRLVETRGHARRRFGSDDPEELVKSLRTRKEGMHAQLQPPVIEEGLRLMPLDRRIVRESELEFNQFPQILAFWRSKNGPLYGEKASTILEHFIERLTKRDGPYRGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Y0</accession>
    <name>A0A1W1I4Y0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1863 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1884"/>
    <dbReference type="EnsemblBacteria" id="SLM48056">
        <property type="protein sequence ID" value="SLM48056"/>
        <property type="gene ID" value="NSJP_1884"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1884"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036490">
        <property type="entry name" value="MTH538_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015032">
        <property type="entry name" value="MTH538_TIR-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08937">
        <property type="entry name" value="DUF1863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52206">
        <property type="entry name" value="SSF52206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1863" evidence="1">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="109" mass="12341" checksum="27B611ED313C284C" modified="2017-06-07" version="1">MLSGQSVFPDSPFEFKDASVKDHLTGDWQEKVRRKMDNIDVVIVLCGERTHTARGVAAELTIAQEKDKSYFLLAAYGDKQCTRPTSAKSTDKLYNWTWENLKTLIDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I501</accession>
    <name>A0A1W1I501_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1900"/>
    <dbReference type="EnsemblBacteria" id="SLM48072">
        <property type="protein sequence ID" value="SLM48072"/>
        <property type="gene ID" value="NSJP_1900"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1900"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="845"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="948" mass="106517" checksum="C094A8B80A43E825" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I526</accession>
    <name>A0A1W1I526_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1817"/>
    <dbReference type="EnsemblBacteria" id="SLM47989">
        <property type="protein sequence ID" value="SLM47989"/>
        <property type="gene ID" value="NSJP_1817"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1817"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="283" mass="31317" checksum="BED8609BC3E903E1" modified="2017-06-07" version="1">MKSESVFQRDRYPTGLMLGLGMYAMMSVACAEHPPQPPFSALPQSRLVDLTHPFGSETIVWPTEQDIKVIVQHAEDMPGGYYYASNRLELPEHGGTHMDAPIHFARGTQTLDQIPIDRLVGGAVRIDVADQCANDRDYRVEIRDLERWESRHGRIPVHAIVLLDTGFGRLWPARQQYLGTELRGAEGVDALHFPGLHPDAAVWLVRERQVKAVGIDTASIDYGRSTKFETHVALLSHNVPVFENLADLSGLPNHGFDVIALPMKIAGGTGGPLRIIAIVPEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I542</accession>
    <name>A0A1W1I542_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1965"/>
    <dbReference type="EnsemblBacteria" id="SLM48137">
        <property type="protein sequence ID" value="SLM48137"/>
        <property type="gene ID" value="NSJP_1965"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1965"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="121" mass="13717" checksum="9BB127E1273CC65D" modified="2017-06-07" version="1">MYEGDKWFDLVVRFLPEFRRDIDSIGQILVQVTGVNVLLRHVRESGHPSLKQGTLLEKALPGFPLPAERTPVFRESCGARMREKCWRGGPIGASMGHGASFLRFRPRHPRHVCGAVRPLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5A6</accession>
    <name>A0A1W1I5A6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2022"/>
    <dbReference type="EnsemblBacteria" id="SLM48194">
        <property type="protein sequence ID" value="SLM48194"/>
        <property type="gene ID" value="NSJP_2022"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2022"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021320">
        <property type="entry name" value="DUF2905"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36443">
        <property type="entry name" value="PTHR36443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11146">
        <property type="entry name" value="DUF2905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="84" mass="9169" checksum="3CF633254929A56D" modified="2017-06-07" version="1">MAEWASLGKVLLGIGAVIALVGLLLLLSDRVPGLGGLLSLFGRLPGDISFKRDNFSLYIPLGTSLVLSILLSLVFYFLSWMFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5H1</accession>
    <name>A0A1W1I5H1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48254">
        <property type="protein sequence ID" value="SLM48254"/>
        <property type="gene ID" value="NSJP_2082"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2082"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="242" mass="27252" checksum="A9C5D1749B806D31" modified="2017-06-07" version="1">MIVILHFRLGQRGLILRTPQHRLETLVDAPTLHELAELPHDRRFVARIHGQIRVLPIAERAQTLKLFALDVAELLGIFPAEPADRRGIEGLLLFAEILQHLMLDRQTMAIPTRHIRHVKARHGFRLDDDVLENLVQGVADMNSAVGIRRTVVEDVAGPPLPGLLDLFVQAFLFPPSQQFGFPLRQVRLHGKIGFGQIKRCFVVHRFGLLCLILIRRLTVDGNLQEEEVGGNLHLASIRHGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5U3</accession>
    <name>A0A1W1I5U3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48311">
        <property type="protein sequence ID" value="SLM48311"/>
        <property type="gene ID" value="NSJP_2139"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2139"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="69" mass="7689" checksum="D2D1100FFB77C9C2" modified="2017-06-07" version="1">MAEPAVTRLHALPTRGSHALWVKPVIFAQFHAVFSLRHHSTREAGTDPPAKVFVFPMRTTECEPGHVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5U4</accession>
    <name>A0A1W1I5U4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48376">
        <property type="protein sequence ID" value="SLM48376"/>
        <property type="gene ID" value="NSJP_2204"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2204"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="2">
        <location>
            <begin position="63"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="471" mass="53051" checksum="F7E07804783E1342" modified="2017-06-07" version="1">MKKASLWVLVGLIVLLSLIFGGEYVRPTMNAPLPKWNPEYGYRFANLPPSVEHSTDSLFMVASFSGGGARASALSYGVLRELAKTPIVWEGYRKNLADELNIINALSGGSFTAAYYALYHDRIFRDFESRFLRKNWEHELRARILQSPRNWLRLLSPYFGRAHIFAELLDEGLFGGATFNDLVSSSQRPIIFIHASDMATVSRFEFNQRQFDLICSDLSKMPLSVATAASSALPLVLSPISLKNYAGECGLDPPAYLSETKRTSWGRRRANELRSYINADKRPYIHLLDGGLADNMGMRSVLELSALVDDLEATFQILGVKKVRKLVFLMVSAETDPDLSHYELDELPSLTRVLNALVDIPINRYSDDTLELMRQAVVQWQVQLHQRARTEKSVFAPDAEIYFIDASLSELDDPVERGRLMSIPTNLALTDSQVDDLLLAGSKLIRSDKDFQRLVRDLKIEAAKAPIISRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5X9</accession>
    <name>A0A1W1I5X9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48404">
        <property type="protein sequence ID" value="SLM48404"/>
        <property type="gene ID" value="NSJP_2232"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2232"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="96" mass="10716" checksum="4E058D7A960C9C80" modified="2017-06-07" version="1">MAGLIPSHWHYPHYPAYFLNTIPADIARDEGGLPCSSVSQLRKGQRECRFTATGTCDRLLMGIKVVDEFGGGHPLPDLFRPTILVKLLQHRRESTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I607</accession>
    <name>A0A1W1I607_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48415">
        <property type="protein sequence ID" value="SLM48415"/>
        <property type="gene ID" value="NSJP_2243"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2243"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="42" mass="4523" checksum="8DEC087E72F17438" modified="2017-06-07" version="1">MRRSSPHLALVKLLAEIAVASYLEKSNPSSAANNQLEVKNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I613</accession>
    <name>A0A1W1I613_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Acylphosphatase</fullName>
            <ecNumber evidence="3 4">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">acyP</name>
        <name evidence="7" type="ORF">NSJP_2274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="3 4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2274"/>
    <dbReference type="EnsemblBacteria" id="SLM48446">
        <property type="protein sequence ID" value="SLM48446"/>
        <property type="gene ID" value="NSJP_2274"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2274"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="6">
        <location>
            <begin position="11"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="102" mass="11032" checksum="F6D2A35EACE27167" modified="2017-06-07" version="1">MTDSTDPATVRATISVAGRVQGVGYRAFALRVAAARGLRGTVRNLDDGRVELDVEGPKERIESLLNDLRTGPPAARVTDVRIEWGRATGRFSDFRISYEGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I623</accession>
    <name>A0A1W1I623_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2219"/>
    <dbReference type="EnsemblBacteria" id="SLM48391">
        <property type="protein sequence ID" value="SLM48391"/>
        <property type="gene ID" value="NSJP_2219"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2219"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="345" mass="39470" checksum="78795B09BA6A645B" modified="2017-06-07" version="1">MGHHLRYLMLVALTGLLAVFLHLSLFVYQLGAPVKAEYWLRELKIVKRVIAANIKGPKLVVLGGSNALVGIDSTMLEETVGIPTVNLALHGALNIHYLLLDAREVLRPYDYLLLALEYEAYTRDPNTLWFTNQVMTWDTTYFWDLPLKDKGTFIHAVPLNRLMAGAVAQLQRGRTANVLHRTVANDDDVLRRYAQAFTDTSTGSREVYSVENVDAHGDLRRLPQSRSYREDSDYGLSTPFVAPAHVWDELREFSEYCQARHITLFFAWPPSIKSPMLDAPAVINHVQQHQAYMRQHRMQMLGLPWEFSYERTFFSDTGYHLTPAGRSKHTEALLRYLRPLMLAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I680</accession>
    <name>A0A1W1I680_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="7">RNAP subunit beta'</shortName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">rpoC</name>
        <name evidence="11" type="ORF">NSJP_2332</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2332"/>
    <dbReference type="EnsemblBacteria" id="SLM48504">
        <property type="protein sequence ID" value="SLM48504"/>
        <property type="gene ID" value="NSJP_2332"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2332"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RPOLA_N" evidence="10">
        <location>
            <begin position="236"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1367"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="796"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="870"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="877"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="880"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1393" mass="154524" checksum="F119F37B7A46E68E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I690</accession>
    <name>A0A1W1I690_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpsS</name>
        <name evidence="7" type="ORF">NSJP_2342</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2342"/>
    <dbReference type="EnsemblBacteria" id="SLM48514">
        <property type="protein sequence ID" value="SLM48514"/>
        <property type="gene ID" value="NSJP_2342"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2342"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="95" mass="10789" checksum="0DCC59454D2BB7E5" modified="2017-06-07" version="1">MPRSVSKGPFVDDHLLKKVEQMNQTKDRKIIKTWSRRSTVVPDMIGHTFAVHNGKKFIPVFVTENMVGHKLGEFAPTRFFKGHGQAKTEKAVALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I693</accession>
    <name>A0A1W1I693_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rplQ</name>
        <name evidence="6" type="ORF">NSJP_2366</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2366"/>
    <dbReference type="EnsemblBacteria" id="SLM48538">
        <property type="protein sequence ID" value="SLM48538"/>
        <property type="gene ID" value="NSJP_2366"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2366"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="136" mass="15355" checksum="CA2E4334C18420A4" modified="2017-06-07" version="1">MRHRKKGRQLGRQTKHRWALFRSLVTSLLEHERIETTEAKAKEIRGFTDRMITLGKDGSLPARRRALSFLRSKAVVTKLFSDVATRFKDRPGGYTRMVKTRRRIGDAAELVAIELVSRTEAPAAKPASPATPAEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6A6</accession>
    <name>A0A1W1I6A6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">rplV</name>
        <name evidence="12" type="ORF">NSJP_2343</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8 11">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2343"/>
    <dbReference type="EnsemblBacteria" id="SLM48515">
        <property type="protein sequence ID" value="SLM48515"/>
        <property type="gene ID" value="NSJP_2343"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2343"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM48515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="116" mass="12813" checksum="7AF2635E5CD774D4" modified="2017-06-07" version="1">MAEARAVLRFVRVAPRKARPVVDMIRGQQVPLALAMLKHLPRHAARVIEKVLRSAVANAEQKELGDSDSMRVSKAFVNCGPTYKRFRARSMGRANAIQKRTSHITVVVEAPGLTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6B2</accession>
    <name>A0A1W1I6B2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">purM</name>
        <name evidence="15" type="ORF">NSJP_2201</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2201"/>
    <dbReference type="EnsemblBacteria" id="SLM48373">
        <property type="protein sequence ID" value="SLM48373"/>
        <property type="gene ID" value="NSJP_2201"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2201"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="13">
        <location>
            <begin position="57"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="14">
        <location>
            <begin position="173"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SLM48373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="345" mass="36716" checksum="1A03C142BFF9F17E" modified="2017-06-07" version="1">MTTYRDAGVDIDAGDEFVDRIKPLVRSTFRPEVLTDLGGFGGLFRFQASRYTDPVLVSGTDGVGTKLKIAFLMDKHDTVGIDLVAMCVNDVAVSGAEPLFFLDYFASGKLSLAKAQKVLEGIAEGCRQAGCALIGGETAEMPSFYPDGEYDLAGFAVGVVDRPKLIDGKSILPGDAVIGLASTGLHSNGYSLVRRILFDKAKLNVDSRVAGLDRPLGEVLLTPTRIYAKQILALASEQPVKGIVHVTGGGITENLPRVLPDGIGARIHRKSWPVPPVFDVVARLGQVDREEMYRVFNMGIGLILVAPASSAAGLVKRAAMLGDRGWVIGEIVAGNSGEPQVEYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6D1</accession>
    <name>A0A1W1I6D1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-dehydroquinate synthase</fullName>
            <shortName evidence="8">DHQS</shortName>
            <ecNumber evidence="8">4.2.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">aroB</name>
        <name evidence="11" type="ORF">NSJP_2378</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2378"/>
    <dbReference type="EnsemblBacteria" id="SLM48550">
        <property type="protein sequence ID" value="SLM48550"/>
        <property type="gene ID" value="NSJP_2378"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2378"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="DHQ_synthase" evidence="10">
        <location>
            <begin position="84"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="122"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="146"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="186"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="390" mass="42392" checksum="0FDCF121216A2D3D" modified="2017-06-07" version="1">MKLKTSDKVSNVPFQAEKVVRVDLGMRSYEIAVEPGLLPTVGSRLAGLTRGRKVGIVTDTHVASRYLTGLRRSLSREGLEPVAIILPPGERSKTLRTAGTVLDVLARHKFDRQSMLVALGGGVVGDITGFAAAIYLRGIPFVQIPTTLVAQVDSSVGGKTGVDHRLGKNLIGAFHQPRAVFIDPDTLRTLPRREWVAGLAEVIKYGIIADEAMFSSLERTMPALLKLDLSAVVPVIVRSCEIKAQIVVEDERETDRRRTLNYGHTIGHALESLGGYRGLIHGEAVGIGLVQEASVASFMGLCGEDVVNRITSLVRLAGLADQMGPVSLPSLWEAMLHDKKAVAGQVIGVWPVRIGETVIKPVDKKVFGDWYKKRVKHTKGLRARNQRSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6N5</accession>
    <name>A0A1W1I6N5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">aroC</name>
        <name evidence="11" type="ORF">NSJP_2488</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2488"/>
    <dbReference type="EnsemblBacteria" id="SLM48660">
        <property type="protein sequence ID" value="SLM48660"/>
        <property type="gene ID" value="NSJP_2488"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2488"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="357"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="293"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="387" mass="41203" checksum="7E5B4F08FBCF939D" modified="2017-06-07" version="1">MAANTFGRLFTVTSFGESHGPAIGCVVDGCPPGLVLTTEDIQKDLDRRKPGTSRHVTQRQETDAVEILSGVFEGKTTGTPIALLIRNQDARSRDYGNLIDTFRPGHADYTYWQKYGIRDHRGGGRASARETAVRVAAAAIARKWLNEKYGVVIRGYLSQLGPLPIPFKNWEEVGANAFFAADPGIVDQLEAFMDELRKSGDSVGARITTVAEHVPVGWGGPVYAKLDADLAAAMMSINAVKAVEIGAGFASVAQRGSEHGDELTPEGFASNHAGGILGGISTGQDIVVSIGIKPTSSIRLPRRSIDKQGNAVTVETNGRHDPCVGLRATPVAEAMLALVLMDHALLQRAQNADVRTATPKIAGSIGRSRQPVRPSSASKVDPEPHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Q0</accession>
    <name>A0A1W1I6Q0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein AraC type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2541"/>
    <dbReference type="EnsemblBacteria" id="SLM48708">
        <property type="protein sequence ID" value="SLM48708"/>
        <property type="gene ID" value="NSJP_2541"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2541"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="234"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="367" mass="41188" checksum="1A3A65CEC29B9171" modified="2017-06-07" version="1">MAAAQKSGETQVDVLIVAVPETAGSALYGMLDVLKAAGSVWETLTRQGDGKSFFNVRIVAPKRKAFVCGNGIPVRPDCVIADEPKALIVILPELWLGPDEDIRDRYPTLMAWLRRAYKQGAFLYSACSGAVMLAATGLLDGCSATSHWAYQDLFRRRYPNVQFHPEPNLVIADRDGRIVTAGGTTSWHDLAIHIIARHANPGEALRIAKVYLLKWHGEGQLPYAPLSRISPHADSVVRECQRQLDRRYRESDVIQQIVEKARIPERTLKRRFKAATGITFIEYVQNLRIEEAKRLLETTGMNTEEIGPAVGYEDYSFFNRLFRRLTGLTPARYRRMFQPVLDGFSVSRTEGGVKSAGFSTRRRSVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6R0</accession>
    <name>A0A1W1I6R0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein DevR (DosR)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">devR</name>
        <name evidence="5" type="ORF">NSJP_2551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48718">
        <property type="protein sequence ID" value="SLM48718"/>
        <property type="gene ID" value="NSJP_2551"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2551"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="11"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="153"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="221" mass="24242" checksum="7FD39CCA7FF1689C" modified="2017-06-07" version="1">MKPQSETKPIRLLLVDDHEVLRIGLRTLFTEAGAFHVVGEAGTMADAVREAAKLKPQVVLMDVRLPDGSGIEACRTIRAHHRDTRVLFLTSFADDDAVLATILAGADGFLLKEVSSKQLIQAVMTVASGRSILDSAVTQRVLAKVRSMSTPAPQHKHDPLSPQEERVLALVAEGKTNKEIALTLNLSDKTVGHYLENIFQKLQVTRRAQAAVFFTQQQSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6X1</accession>
    <name>A0A1W1I6X1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2577"/>
    <dbReference type="EnsemblBacteria" id="SLM48744">
        <property type="protein sequence ID" value="SLM48744"/>
        <property type="gene ID" value="NSJP_2577"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2577"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="SSF50405"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012529062" evidence="2">
        <location>
            <begin position="24"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="399" mass="42517" checksum="982F198E60875C2D" modified="2017-06-07" version="1">MQHARPVSIFVAGILVFNLAACATESTPSVSQDAQAVSTTDTNPQPGQLPDSDIQERGLSPRLKPSVGSQIPSRPIQLAPTPLPGAFAIQTFNQNFVTAVDGGGRTTNVLHTDARGIGAWEQFKLLGGSGFGGQYAFQTMKGTYLTAVNGGGLSNAVLPNGQPTDPLHTDATQVQSWETFKIVLDQYGWRNAIQTVNGHYLTAVGAGGKTTDAFHTDAVKPNSWEQFYLWKCGDLGSGYQYAISALNGPSGVLFAYGGGGHVATHPDIVVTGALGVLSDYNARPQPFDNAWQRFRLIRQGDGSYALQTSNGINYVTAVKGGGLPHGTISYDSLVTDRTQVQAWETFRFVEHGACTYVIQTVGGYYLGKSTAAPGTALGWFATNVQDINAATKFRLLMVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Z0</accession>
    <name>A0A1W1I6Z0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2597"/>
    <dbReference type="EnsemblBacteria" id="SLM48764">
        <property type="protein sequence ID" value="SLM48764"/>
        <property type="gene ID" value="NSJP_2597"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2597"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="2">
        <location>
            <begin position="14"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="403" mass="45397" checksum="8C49CC64D0CE7A5C" modified="2017-06-07" version="1">MRSLSDKFGKVIFVFCGGGCKAIIQAVAAAEFVNAGITPSHIVSSSAGSCNALGFVENPGPVGAEKTVRIWEDYITSPEAIYEVHPFFREKLARLLGVVPRATKGLAPGSAFHDVKRAFRFFPLVFSLGLRMPFRAAGRAVSFIFRLMDTFESQQKSFRRLVQSPEILEAFGEVDKYFEFKRMKAFLDPFPLLAKLGEQIDLQKVIGSSIVWHIMTERYEDGATVVFSNKDADVRAAIGGDAKTQKVVYDAFFKRIRASMALYPLFEMVEMDGYRYLDADLANPLPVEEAFSHGCDTVVIFLNVPANSVRIDPHPLRDLLELNDLLRLNERYIHHRLQEAQMKAKETGVNLFVVRPESIPPGLGLLDIDDKVIEYVKQHERQRMKEYLADLDAHNLRFSPPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I726</accession>
    <name>A0A1W1I726_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Response regulator with HD domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2655"/>
    <dbReference type="EnsemblBacteria" id="SLM48822">
        <property type="protein sequence ID" value="SLM48822"/>
        <property type="gene ID" value="NSJP_2655"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2655"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="15"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="179"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="384" mass="42332" checksum="FDD6811CC61B17CF" modified="2017-06-07" version="1">MHVALSEKRSQAKPTVLVVDDEAGPRDALKVILRPFFNIQAAGSARAAIDVLNSQQIDLITLDQKLPDRQGLDLLQEIKHDHADVEVIIITGYGSLKAAMDGIRHGAAGYLLKPFNVTELVTLVNQTLHKKQRLDYLRRFVHYPEAMWESEASCAATWNEIRSGYAAISAQPDVMTATEAAEFRFLLPLLSDLLEAKERELLNHCSRVSFYATLLANRMDLTEGEQKSLALGAFLHDIGRIVAGPCHFADDAIRSLGGTQDHKRHTELGVRMIEPLGLPAEVGQIIGYHHERWDGTGYPHGLQGEGIPLLARIVCLAQAFDHLTAELPDRNSLSLDEACDFITGHTGDYFDPTLTTLFVRVVQECKASLPAMAIATNPSRPPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I731</accession>
    <name>A0A1W1I731_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transglut_core3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2451"/>
    <dbReference type="EnsemblBacteria" id="SLM48623">
        <property type="protein sequence ID" value="SLM48623"/>
        <property type="gene ID" value="NSJP_2451"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2451"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032708">
        <property type="entry name" value="McjB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13471">
        <property type="entry name" value="Transglut_core3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglut_core3" evidence="1">
        <location>
            <begin position="19"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="156" mass="17814" checksum="14A4EFB44EAD31FD" modified="2017-06-07" version="1">MIQMLSKYGTIALVGLLVCAVRFLLRWKSLPNVLGMLDRGALAAGRDLATLEHRVYYLDRWLELLPYNTKGNCFPRAVTLYWLARRAGCPVRLHCGIKREGLKLDGHAWLTLDREPFHEPSDQWRQYAVTFSYPELTVSEEGTHSRPTPTDSARVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I786</accession>
    <name>A0A1W1I786_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48845">
        <property type="protein sequence ID" value="SLM48845"/>
        <property type="gene ID" value="NSJP_2678"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2678"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="71" mass="7708" checksum="9CF93AFFDF5B3A3C" modified="2017-06-07" version="1">MVSALKVFLWWFVIGATMALAVIMLQGGIREVMQAQGSVWELKLVELMTTIMGGGLLGGCIALILDRIKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7D6</accession>
    <name>A0A1W1I7D6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48779">
        <property type="protein sequence ID" value="SLM48779"/>
        <property type="gene ID" value="NSJP_2612"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2612"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="28" mass="3137" checksum="BC386E748A15BB19" modified="2017-06-07" version="1">MKAPLRVPTNSRTLLMDGSFLTYKPLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7G1</accession>
    <name>A0A1W1I7G1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48940">
        <property type="protein sequence ID" value="SLM48940"/>
        <property type="gene ID" value="NSJP_2773"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2773"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013184479" evidence="1">
        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="209" mass="23402" checksum="EC4DEC3298256AC1" modified="2017-06-07" version="1">MRTFLTTTAFIMCCSGPSMAQIQEPLPSPTFTIPFDEIDEAELQAEVSGQVTAFLQTVHAHLGKDRAALRTSVVGDVREDDQSKLIYLRNIGDHGVLEGYEFSRDTLAHGQYVLLQRPLNGLNEFIGYYLALKRTLTDTYGAPTDDHVVWDNDLYQPLPDYWGVAVMIGHLRYHATWNTPDGTVTLELTGARHSRLSVDYRIRDAGALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7H9</accession>
    <name>A0A1W1I7H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48819">
        <property type="protein sequence ID" value="SLM48819"/>
        <property type="gene ID" value="NSJP_2652"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2652"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012551622" evidence="1">
        <location>
            <begin position="32"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="182" mass="20326" checksum="9C92C445ACA13E4F" modified="2017-06-07" version="1">MKQGLLSRVECKRPVAGLCLALLLCWSGANGAWGGQDGPLPHLHRAKIYLAAGDFRRAIEACRHEVDARPSVEAYLYLTYVYQALDAYVESLAKADQWVPLEHLYLSLVTGKPEDLVDAPDVLSRIAKELMQSGARQQADIAAELATRLDSAAVARIWPQQTAWRKSKPDGWWFGIPPEWSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7J5</accession>
    <name>A0A1W1I7J5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2825"/>
    <dbReference type="EnsemblBacteria" id="SLM48992">
        <property type="protein sequence ID" value="SLM48992"/>
        <property type="gene ID" value="NSJP_2825"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2825"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004380">
        <property type="entry name" value="Asp_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF7">
        <property type="entry name" value="PTHR21198:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00035">
        <property type="entry name" value="asp_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="266" mass="29526" checksum="A079DEE09E4FF06D" modified="2017-06-07" version="1">MTYLPFEAIPHIGIVAGTAEGAALCYRTLCHEAERFMGRHAHPEITIHTFSLRSYFDLIDGDDWPGVADLLSRSANKLAHAGADFIICPNNTLHRAYDLVQSPVPWLHIAATVAAEAARRGFHRVGLLGTRAVMEDSMYSRHLNKEGIELIIPLADERDNIQRIIRHELIAGRFTSHTRNVLRAVINRFRTSGCDAVILGCTELPLIVSSEGSPLPLLDSTRLLARAALEQVECRQTPDDHIETSEHRNMVGMATGRFHLVSSDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7M8</accession>
    <name>A0A1W1I7M8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2850"/>
    <dbReference type="EnsemblBacteria" id="SLM49017">
        <property type="protein sequence ID" value="SLM49017"/>
        <property type="gene ID" value="NSJP_2850"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2850"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="164"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="239"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="496" mass="54873" checksum="192AD2111E69AD9B" modified="2017-06-07" version="1">MGVTAYRRQQADLSANRAAGFSPAQSGPQPDTCRDNQNEWASTILDSLGQRLAVLDSRGTIVASNDAWREFSRSNADCSHAAAETGINCLDRWHEAAQAGSHQDAQILAGVRNVLSGISPSFEFEYMWSSPTGPQWFLLTAVPLRRKEGGAVITHLDVTSQKLTDRQYGSLIESLGAIVWKAEPASLRFTFVSKQTEAILGYPREQWYRQNFLASHLHPDDQLRVLASCRRSVEGKRHRTLDYRMLTAAGDTVWLHSSIHVITEGGHTKELIGIMIDITDYKRAETSLKEMTGRLLGVQEEERRRIARELHDNLNQRLALLAIGLQRLDFSPGAEPEAQVESLHTLTQELASDIHRLSHRLHPAKLEHLGLVAAINGLCRELSEQHAVRIDCLHRDVPRAIPKEAALCLFRVAQEALSNLVKHSGVESGKLELIGDRGALHLCVSDAGAGFDLRAASAKGRLGLISMQERVRTIGGRISIESFPSRGTRIVVQITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7R1</accession>
    <name>A0A1W1I7R1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Patatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49040">
        <property type="protein sequence ID" value="SLM49040"/>
        <property type="gene ID" value="NSJP_2873"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2873"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="64"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="485" mass="54692" checksum="57B9916CBF9B8EBC" modified="2017-06-07" version="1">MMQWRIGKSPWFAVLLLLSFAGCEYVRPTLNQPLETWNPTGGYRFTNVAPPESDNSDSFLFVAAFSGGGTRASTLAFGALRELALQEIVWEGKRKRLLDELDLIHALSGGTFTGGYYALYRDRIFHDFEYRFLRKNWENELKARVFKSPSNWIRLWSPYFGRAHLMSELLNEALFDHKTYADLAALHQRPMLIIHASDMATLARFEFTQFQFDIICSDLSQLPIADASAASAALPLVLSPISLKNYANNCKYEVPAWLEEAKRRGKIGGQRANELLSYTDVKKRPYIHLLDGGLSDNLALRGIIENSGLQGGFEKLLVAAGVKNIKKFVILTVNAETSPDVMEFRSDHVPVISKAMSSLVDIPINRYSFDTTTLIKMGVEKWRTELQLKPRPPGGPFAEDADIYFINASLNEIEDPDERISMMKIPTTLYLTDDQIDRLVTTAAKLIRNDKEFQRLMKDIKAPDIPAPSERTSESQPVGAEAQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7R9</accession>
    <name>A0A1W1I7R9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3943 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49072">
        <property type="protein sequence ID" value="SLM49072"/>
        <property type="gene ID" value="NSJP_2905"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2905"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025079">
        <property type="entry name" value="DUF3943"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13084">
        <property type="entry name" value="DUF3943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012393408" description="DUF3943 domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3943" evidence="3">
        <location>
            <begin position="126"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="505" mass="56221" checksum="598DC316DA4CC225" modified="2017-06-07" version="1">MKRKAVRWLLFLIGVVALTFAPIHSSLAQDPTVDSSPIQGPPSPFEPPPAHVPHQPADKVIRTTRDWWNDKLVWETGAGRSYVLPAGEILAYEFFLNLFDRNFVEPKSDYQTDWNTIWNHLSDGKWVIDNDQFSVNQFLHPYGGSIYYGLARSTGLNFWESFLYSVAGSFVWEIAGETTNPSINDMIATPIGGTFLGESFFRMASLLLEDSDGKPGFWRELGAAVISPPMGFNRLVFGDKFDAVFPSHKPATFMRLQAGGTISSSSRNVSSSVEETGAIADFTFSYGLPGKPGYTYKRPFDYFDFHVTAVTANVLESLNIRGLLLGTDYSAGNSTRGIWGLYGNYDYISPQVFRVSNTALSLGTTWQSWLSQNVAMQGTALAGAGYGAAGNIEQTGERDYHYGLTPHALLSLRFMFGDRVMVDLSGREYYVSNTFASEEGWEHIMRGDSSLTVRVYDRHGLAVRYSHSHRNASYPAIEFKDQSVGTVSLMYVFLGETGFGTVEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7S2</accession>
    <name>A0A1W1I7S2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49050">
        <property type="protein sequence ID" value="SLM49050"/>
        <property type="gene ID" value="NSJP_2883"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2883"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="19"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="225"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="290" mass="31235" checksum="57AB70EEC4514620" modified="2017-06-07" version="1">MPAADSNDVAILQQVFHPSDFTPASETAFAHALKAALVAQADLTILHVSTKENSDWTEFPGVRATLERWGLLPRNSSTSDVAKLGIGVKKIQARHDDPVESVTAYLKSHNADLIVLATDQSKEQFQWLSKSVAEPIARKTRLMTLFIPKGLNGFVSLKDGSISLNSILIPVATVPPPQPAIQAAVRLARRMNIPKGVFNLVHVGDKTTMPAVSVPDLPGWTSNVLTKQGEVIDVIVETAAEVKADLIVMTTDGRNGFLDALRGSHSERILRRTPCPLLAIPAGGFISSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I828</accession>
    <name>A0A1W1I828_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative RNA polymerase sigma factor, sigma-24 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49156">
        <property type="protein sequence ID" value="SLM49156"/>
        <property type="gene ID" value="NSJP_2989"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2989"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="38"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="133"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="200" mass="22609" checksum="D93C8BF999C8D46A" modified="2017-06-07" version="1">MDTPTRRATSTIDPALFARIVKGDQQAFSELYDLSCTLLYTLAIRILGNREEAEEVLQDVYLEVWRKVARYDVGRGTPVAWLITLTRSRAIDRLRARSARGYQTTDSLERDAAAQIRDMSPSPFETQADQELRLAVGTAMASLPAAQQQAIELAYYEGLSHMEIAARLNQPLGTVKTRIKLGMSKLRDTLRHCWDQGEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I844</accession>
    <name>A0A1W1I844_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulator of SigK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sigma-K anti-sigma factor RskA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_2988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2988"/>
    <dbReference type="EnsemblBacteria" id="SLM49155">
        <property type="protein sequence ID" value="SLM49155"/>
        <property type="gene ID" value="NSJP_2988"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2988"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018764">
        <property type="entry name" value="Anti-sigma_K_RskA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10099">
        <property type="entry name" value="RskA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="145"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="339" mass="37143" checksum="CD1BA6DB2DDCDD49" modified="2017-06-07" version="1">MTHEEIEDAVPLYATGVLDRAERQALEAHLLSGCTSCHHALKEYQAVAAMLPLGLAQTSPARNLKAQIMASRNPVAAALENGQKDEPKPSLEPGEWMNHLFPPITPARSVSLPWALGIAAVLLVTVAGYLGWSFTTRLSSDGAKIEQLETALQEQTTKLVGLQRVVADRDRTVAILERDGERRGHDIAELKEQLIERETELEGLEQQLTSRSAAGARGKTPQDELAALLRQPSIRVVSLNGSEMAKNASGLLLYDAKTQKIWLYAVNLPECVNGTMYQLWAIDQRPKSIGTFHMDSGETAHLMVKRLPDFERTKKFAVSLEPPGGRPQPTGALYLVSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I854</accession>
    <name>A0A1W1I854_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4384 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3009"/>
    <dbReference type="EnsemblBacteria" id="SLM49176">
        <property type="protein sequence ID" value="SLM49176"/>
        <property type="gene ID" value="NSJP_3009"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3009"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025493">
        <property type="entry name" value="DUF4384"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14326">
        <property type="entry name" value="DUF4384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012099606" description="DUF4384 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4384" evidence="3">
        <location>
            <begin position="548"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="750" mass="79669" checksum="3246E77B61F952D2" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8A0</accession>
    <name>A0A1W1I8A0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3067"/>
    <dbReference type="EnsemblBacteria" id="SLM49234">
        <property type="protein sequence ID" value="SLM49234"/>
        <property type="gene ID" value="NSJP_3067"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3067"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="5"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="72" mass="7705" checksum="E50211CD4911FB59" modified="2017-06-07" version="1">MDKLVSVKEAAKRLSCSEDTIWKWLKTGSLRRLKVGRLTRINEQDLDAVVRVGLPIGGKAGASAGVSGPTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8C6</accession>
    <name>A0A1W1I8C6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2886"/>
    <dbReference type="EnsemblBacteria" id="SLM49053">
        <property type="protein sequence ID" value="SLM49053"/>
        <property type="gene ID" value="NSJP_2886"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2886"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="193" mass="20486" checksum="EDC0D659B92FD943" modified="2017-06-07" version="1">MTIIKKSAIRSALILVIVTAVGCAGGLVGSKEKKLAYFNSLEQETLARLVKEHPKAEQELRDSVGYLVAEKDVVKVPMFGAGGGAGVVFDKETATRSYLRIPELQFGAGWGGRAEKVVLIFQDVHKLRDLADGKWHAGMEAEATAKVADVGLAGSGNTTELLKKGFSTYVLTDAGASATATVSMIRAQPYSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8D1</accession>
    <name>A0A1W1I8D1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49282">
        <property type="protein sequence ID" value="SLM49282"/>
        <property type="gene ID" value="NSJP_3115"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3115"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="111" mass="12350" checksum="A7DDA07E0E2E5C8E" modified="2017-06-07" version="1">MERRAASHTEEEEMNQRRRLLNAAKKGDQKAVAKLFELYQVRVYNSEMVTKLNRAAGTHKLQSKGAPGKQPKGAVPAKNAPAKGKHQQVKDAPQKKSGPLQTKDRAAKHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8H3</accession>
    <name>A0A1W1I8H3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmid replication initiation factor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3155"/>
    <dbReference type="EnsemblBacteria" id="SLM49322">
        <property type="protein sequence ID" value="SLM49322"/>
        <property type="gene ID" value="NSJP_3155"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3155"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003916">
        <property type="term" value="F:DNA topoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003491">
        <property type="entry name" value="Rep_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02486">
        <property type="entry name" value="Rep_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="344" mass="38448" checksum="7C6DFFD305945795" modified="2017-06-07" version="1">MSWTCLVGWLRFTVPQAIVDEVMTLMGGDWVADEKGFLGYGRSWICRGQTGGYGRIGTGAKRAPQEVHVDLSQELLSGWTYQQFQAVAQWVFAKDGHFGRLDVALDDRSGIIDVDGIYVAVVAGHCVSHFRKSQLIAGLDVGSGADTGKTLCMGSRQSDTYLRIYDKAAQQQSKGIVVEGPWVRWEMEWKDERAQAVGLALSVLDQERFQAYIVGVFRTALDFRDCTRADDPKDRYHAPLLPWWKTLTEGMQRAKLEVVKAVKKIEDVKQWAAKSLSPMLGLLCVHPEAGERWLVSTIIEGVERWRAKHYALLAKGQDAQQVLKKVRWWKPTDGFAAGCASTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8S6</accession>
    <name>A0A1W1I8S6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdopterin synthase sulfurylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">moeB</name>
        <name evidence="3" type="ORF">NSJP_3102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3102"/>
    <dbReference type="EnsemblBacteria" id="SLM49269">
        <property type="protein sequence ID" value="SLM49269"/>
        <property type="gene ID" value="NSJP_3102"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3102"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="ThiF" evidence="2">
        <location>
            <begin position="11"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="270" mass="29065" checksum="FB9E09986CFDFC1F" modified="2017-06-07" version="1">MEFTEEQINRYSRHILLPEVGGKGQKKLAKARILLVGAGGLGSPAALYLAAAGVGTLGLIDSDVVDITNLQRQILHHTSDVGRPKVLSGKEKIHGLNPDVAVTMYEERLTAGNAIKIFQDYDVVIDGVDNFTAKFLINDACFFADKPLVHGGILRFDGRVTTIIPRKSACYRCVFKSPPPAGLVASCQEAGVIGVLAGVIGTIQATEALKLVLGIGRPLTDRLLDYDARKTQFREIRVKRNPACALCGEHPTITELFDDGDPFAGCASRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8W5</accession>
    <name>A0A1W1I8W5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49478">
        <property type="protein sequence ID" value="SLM49478"/>
        <property type="gene ID" value="NSJP_3311"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3311"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="92" mass="10644" checksum="9C78777458CF43A8" modified="2017-06-07" version="1">MARSRRPELEKDNPSAPQTYVGRRRKRNTLHVDAEHGMIETLEHLTDAAERFINRVPRLRKHEAERLALLDAITQAQLTLSVHTVPSHHPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8X5</accession>
    <name>A0A1W1I8X5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49329">
        <property type="protein sequence ID" value="SLM49329"/>
        <property type="gene ID" value="NSJP_3162"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3162"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="42" mass="4446" checksum="FDF297E3AF190218" modified="2017-06-07" version="1">MVTQINQLGSMMAADVIAWGAAVIGIALTASAIIWVMRLMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I916</accession>
    <name>A0A1W1I916_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA_13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3254"/>
    <dbReference type="EnsemblBacteria" id="SLM49421">
        <property type="protein sequence ID" value="SLM49421"/>
        <property type="gene ID" value="NSJP_3254"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3254"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026866">
        <property type="entry name" value="CR006_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13166">
        <property type="entry name" value="AAA_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_13" evidence="2">
        <location>
            <begin position="10"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="407"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="741" mass="83052" checksum="0A66D5FBD6873123" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9D3</accession>
    <name>A0A1W1I9D3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate hydratase class II</fullName>
            <shortName evidence="2">Fumarase C</shortName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Aerobic fumarase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Iron-independent fumarase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">fumC</name>
        <name evidence="6" type="ORF">NSJP_3428</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3428"/>
    <dbReference type="EnsemblBacteria" id="SLM49595">
        <property type="protein sequence ID" value="SLM49595"/>
        <property type="gene ID" value="NSJP_3428"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3428"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lyase_1" evidence="4">
        <location>
            <begin position="27"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="5">
        <location>
            <begin position="423"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding (B site)" evidence="2">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="338"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="485" mass="51573" checksum="CE1A9D5D0F1E0407" modified="2017-06-07" version="1">MKQTRDSHATAPSSSDGATRIERDTMGELAVPADAYYGVQTARAVENFPISSLRMPRSVIRAMGLIKRAAASVNHSLGLLDQRHADAIRQAAAEVVEGKLDAQFPVDIFQTGSGTSTNMNTNEVISNRATELLGGARGSKLVHPNDHVNLGQSSNDVIPTAIHIAASETIQRQLLPALSRLHRALEDKAREFDKVVKIGRTHLQDATPVRLGQEFGGYARQIELGIARMKRAQEALSEVALGGTAVGTGLNCHPEFSGKVMAIISQETGCRFQEAVNHFEAQSAQDSLVEASGALRTLAVSLTKIANDVRWLGSGPRCGLGEISLPETQPGSSIMPGKVNPVIAESVTMVCAQVVGNDVTVTVGGQAANFELIVMLPVMAYNLLQSIELLATASNNFSAKCIEGIKANEARCNSLIEESLAMCTALAPEIGYEAAAKLAKDAFKSGKTVRQVAQEQHVLPEKRLTELLDPWRMTEPGGPVGSAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9E4</accession>
    <name>A0A1W1I9E4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Histidine kinase</fullName>
            <ecNumber evidence="8">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_3490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49657">
        <property type="protein sequence ID" value="SLM49657"/>
        <property type="gene ID" value="NSJP_3490"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3490"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029095">
        <property type="entry name" value="NarX-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13675">
        <property type="entry name" value="PilJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="238"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="467" mass="51251" checksum="520415215C0511F8" modified="2017-06-07" version="1">MADIVLAPADYARPAKWTVAGIFGLLVITLLAFVPLTMTFLQSLDSDALLIDLAGRQRMLLERHMKELLLSAQELPSTYDQTRRTLGERLDTLLNGGTVIVRSDRQAVILSGAPTAEIRERLLDQRRLLESFEAKADRYFRTQTASPERAAARDELLADNAVLLETANAAVELLTRYSEARSRRLIQWETWTVLLVVTVTSLLIWRFIETEKALQRSERAIVEALRQSDAMKSALLSSVSHELRTPLTAIKSMLFSLRDDPGAQSSPVRQEFVRSMDKQLDHLNRFVGNLLDMSRLESGGLPSRREWHVLDELAEGAIRVAAPVLEGRVLKIELASDIPPVYVDGMQIQQVLINLLENAVKFSAPSSSVRLAAAVAGDTIEVSVSDTGAGIPADELSRIFERFYRAQSARNGGIPGTGLGLAICKAIVEAHGGRIVATSVPAEGTTIMFTLTTSRDPLRGPSGSTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9E5</accession>
    <name>A0A1W1I9E5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ca(2+)/H(+) antiporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3332</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Ca(+)/H(+) antiporter that extrudes calcium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49499">
        <property type="protein sequence ID" value="SLM49499"/>
        <property type="gene ID" value="NSJP_3332"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3332"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="PTHR31503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="24"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="206"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="352" mass="37218" checksum="994985A84422089A" modified="2017-06-07" version="1">MSLNWLLVFIPLALGLDWYGASPIAIFCVSALAIVPLAGLMGQATEQLSIYVGATIGGLMSASLGNAPELIISGFALKEGLGDIVKASITGSILGNLLFSLGLSMIFGGWGRQRQQFNKTVAGVNGGLLFVAAVGLLIPALFHFATGKEREVSTEIAIVLFFAYIASLVFTLKTHRQLVETEPGQYGPGKEQVEEEEGRWSKGKAIAVLGGVTVLIAIMSEMLVGAIEPASASLGFTPIFAGVIFLALVGNAAEAMNAVRFARNDQMDLSFGIAVGASTQVALFVAPVLVFLGYAVGQPMNLHFTYFEIIAITLTVAVVSRLTSDGECNWMEGVMLVCVYLMFAIGFFFLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9R5</accession>
    <name>A0A1W1I9R5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="2">M1Pi</shortName>
            <shortName evidence="2">MTR-1-P isomerase</shortName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">mtnA</name>
        <name evidence="3" type="ORF">NSJP_3565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3565"/>
    <dbReference type="EnsemblBacteria" id="SLM49732">
        <property type="protein sequence ID" value="SLM49732"/>
        <property type="gene ID" value="NSJP_3565"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3565"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="45"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="246"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="342" mass="37021" checksum="D5496B5F66955B2B" modified="2017-06-07" version="1">MVPTVCWHEGAIRLLDQSRLPEHVEILECRDVESVARAIRELKVRGAPAIGVTAAMGVALGAQLSEAENYFQLENDLSGVCELLAATRPTAVNLFWAIERMKRTLHELRSQPLSAIKTGLVRESQSILEEDIALCKAMGRHGARLIEDGQTILTHCNAGALATAGYGTALGVVRAAWEEGKRIQVIADETRPVLQGARLTAWELMQDGIPVTLITDGMAGIMMRQGKVQLCIVGADRIAANGDVANKIGTYSVAVLARAHGIPFYVAAPYSTIDLKTPSGNDIAIEQRNPQEVTTMLGDRIIAPKGVSVYNPAFDVTPAEFIAGIITERGVFRPHEVLRHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9S8</accession>
    <name>A0A1W1I9S8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">radA</name>
        <name evidence="8" type="ORF">NSJP_3366</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3366"/>
    <dbReference type="EnsemblBacteria" id="SLM49533">
        <property type="protein sequence ID" value="SLM49533"/>
        <property type="gene ID" value="NSJP_3366"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3366"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01121">
        <property type="entry name" value="Sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="7">
        <location>
            <begin position="65"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="5">
        <location>
            <begin position="350"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="5">
        <location>
            <begin position="251"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="94"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="453" mass="48573" checksum="1A8B9AA6DDCC9AFA" modified="2017-06-07" version="1">MKAKTVFSCQACGHQSPRWLGRCPDCGGWNTMKEERQAPTGKGRPAAMTAAPARATPIADIEVVGENRRLTRIGEFDRVLGGGVIPGAVVLIGGDPGIGKTTLLLQALPRLASSSQPVLYVSGEESPRQIKMRGQRLGVEHPHLLILAETSLEQILKAIQEIGPAAVVVDSIQTVYTEQMTSAPGSISQVQEVAGQLMWFAKRAGVPVFIIGHVTKDGAIAGPRLLEHIVDTVLYFEGDKGHSYRILRAVKNRFGSTNEIGVFEMKDAGLEEVSNPSELFLAERPQRSTGSVVVSSLEGSRPILVELQALVSPTSYPMPKRMTNGVDLNRVSLLLAVMDKRLGVHLSGQDVYVNVVGGMHIDEPAIDLGIVSAVTSSLREIPVEPGLLILGEVGLGGEVRAISQAELRIREAAKMGFKRALLPERNLPKLEGVEGIELIGIADVREALDVVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAD6</accession>
    <name>A0A1W1IAD6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3788"/>
    <dbReference type="EnsemblBacteria" id="SLM49955">
        <property type="protein sequence ID" value="SLM49955"/>
        <property type="gene ID" value="NSJP_3788"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3788"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="173" mass="18847" checksum="34A4EE2EE9EF26BC" modified="2017-06-07" version="1">MTSRERVIRAKLSILAIAAELKNVAKACRLSGVSRSQYYALRRTLNTQGRDGLAPKIRRKPVMPNRTPALMERQILLKTHSNPTVSYVRLARQMTLDGVSVTPGMVRYVWEREGLSTRSARLRWVKGAKGHIDSPAVALAASVTATSSVSLCGPAECFAQASRCSSAHGSPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAF8</accession>
    <name>A0A1W1IAF8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 6-phosphogluconate dehydrogenase YqeC</fullName>
            <ecNumber evidence="5">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yqeC</name>
        <name evidence="5" type="ORF">NSJP_3734</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3734"/>
    <dbReference type="EnsemblBacteria" id="SLM49901">
        <property type="protein sequence ID" value="SLM49901"/>
        <property type="gene ID" value="NSJP_3734"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3734"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="4">
        <location>
            <begin position="167"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="297" mass="32187" checksum="C0144B452563CFD4" modified="2017-06-07" version="1">MELGFIGLGKMGMNMVTRLRRDQHRVVVYDRSADLVSQATTHGCIPASSLADLTAQLNAPRAVWCMVPAGAPTEETIRALGTLLKSGDTIIDGGNTNFHDDVRRADELKGKGIAYLDAGTSGGVWGLEAGYCLMVGGDKAAVERLAPVFTTLTPENGWAHMGAVGSGHYVKMVHNGIEYSMMQGYAEGFELMSKSDYRLDLPRIADLWMQGSVVRSWLLELAAGALKENPKLDHLKGFVQDSGEGRWMIADAIEKGVPVPTLASALFTRFRSRQDDSFAEKMLAALRNAFGGHAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAH3</accession>
    <name>A0A1W1IAH3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Polysaccharide export protein (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3825"/>
    <dbReference type="EnsemblBacteria" id="SLM49992">
        <property type="protein sequence ID" value="SLM49992"/>
        <property type="gene ID" value="NSJP_3825"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3825"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012484085" evidence="2">
        <location>
            <begin position="28"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="159"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="254" mass="26927" checksum="0E184B22F343BFFB" modified="2017-06-07" version="1">MTHLYTAVSMGLAVVICSAAVSGNAQSGTASSVPTAKMGTDASVLHVSPVSIEKVESPAYADGTRSAVDAAEKLFNAVTGDYLIGAEDILEISVWRNPDLSRVVQVRPDGRISLPVVRDIVVIGKTPSQLGDELTKKLKEYVQNPVVAISVKEVNSYNVFLLGEVLKPGKYPLKSKTTLLQGITIAGGFTPVAARNQVVIFRFDENGNGTRTLSASYDDIVLRGGIGQNLELKAGDTVVVPSETMVVFPGQRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAR2</accession>
    <name>A0A1W1IAR2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase, sigma-24 subunit, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50082">
        <property type="protein sequence ID" value="SLM50082"/>
        <property type="gene ID" value="NSJP_3915"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3915"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="121"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="184" mass="20271" checksum="F3574CB79433C36C" modified="2017-06-07" version="1">MTEPNSESSPQPFGESQLFNAFHACVKELKSFLTRRVGCPEAAADIVQDTYIRLAMRGEQPRHTNPRALVFRVAANLATDHARHERMREKLDAGSIDDLVVASTAPAPDAAIAAKQEDRLFKQAIAALPEKCRMVFLLRMSQELSYGQIADRLGISISAVEKHMSKAIIHCRGYVEGRGDASHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAS4</accession>
    <name>A0A1W1IAS4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3854"/>
    <dbReference type="EnsemblBacteria" id="SLM50021">
        <property type="protein sequence ID" value="SLM50021"/>
        <property type="gene ID" value="NSJP_3854"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3854"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012190352" evidence="2">
        <location>
            <begin position="35"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="375"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="461" mass="50950" checksum="0B392AEE98B719FE" modified="2017-06-07" version="1">MSPRFASRVRFFVRSLCSCLLLASVTSSTFSAWAQMGKPEGLYYKSWAVVIGIENYVVAPKLPGAREDAKAMAQALRGLGFEEVVELYDGEASFRRLQQLLSDFLPRKVGRQDRLVIYFAGHAGMARDQSGSEAGYLVPWDAQPNNVSKAVTFDQLKEFSRRTASKHTLLLLDVAVRGWEVSAAQPLSLEGRITPEDDQEKRAVQVLTAGDKGETAVRTQDRSLFVQVLAAGLAGAADLDKNGWLMASELGHYAIQQIQEQSKGAQHPLFTQLEGDGDTILIEGRKAAFRLGGEPQSPAERKQAAKLQYEQAFALLQTGKSADEALDRLNRALEYDPEYGDAYVLKSYVRLEVLPDLNEALSAGTLAVQHAPKNPDSHYTLGLIYEKRGQYQEAEQAMLNALAVNPAYMDVYFSLGVLYEDELKNDQKAIEAFQRYLELGGNHVRAREAVARGNRSQPGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAU8</accession>
    <name>A0A1W1IAU8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transketolase</fullName>
            <ecNumber evidence="8">2.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tktA</name>
        <name evidence="8" type="ORF">NSJP_3874</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3874"/>
    <dbReference type="EnsemblBacteria" id="SLM50041">
        <property type="protein sequence ID" value="SLM50041"/>
        <property type="gene ID" value="NSJP_3874"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3874"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="7">
        <location>
            <begin position="317"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM50041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="621" mass="66101" checksum="905D71BB4C36A380" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAW3</accession>
    <name>A0A1W1IAW3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49913">
        <property type="protein sequence ID" value="SLM49913"/>
        <property type="gene ID" value="NSJP_3746"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3746"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="73" mass="8609" checksum="83B62F4E4B12CD28" modified="2017-06-07" version="1">MQQRRAVEHTLEVGEAELKKGWEEKCGYLMDCKVLIGQYLTNYSESYCRLLFLRNRSSLASFEWAAMRDVSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAX0</accession>
    <name>A0A1W1IAX0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">pyrG</name>
        <name evidence="12" type="ORF">NSJP_3979</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3979"/>
    <dbReference type="EnsemblBacteria" id="SLM50146">
        <property type="protein sequence ID" value="SLM50146"/>
        <property type="gene ID" value="NSJP_3979"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3979"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="3"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="300"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="380"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="146"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="186"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="238"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM50146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="533" mass="59350" checksum="14AC331EBE10443F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBA2</accession>
    <name>A0A1W1IBA2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50270">
        <property type="protein sequence ID" value="SLM50270"/>
        <property type="gene ID" value="NSJP_4103"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4103"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012144914" evidence="1">
        <location>
            <begin position="25"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="147" mass="16254" checksum="9E5FA1338770AB2B" modified="2017-06-07" version="1">MKILTRVAMLNVVALLICTLPVSAFAVASDEATHQSDHQEDVLELPEVHVHGLSLNKDQQLGPVPKSTPWPRIPPALEGTILDDWMKARVLVSKAAKTTVIVLEPAKHRELTQAGIAALNKWTFDPQMKGDDPVDGELTVRIHFRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBD9</accession>
    <name>A0A1W1IBD9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tagO [H</name>
        <name evidence="7" type="ORF">NSJP_4128</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4128"/>
    <dbReference type="EnsemblBacteria" id="SLM50295">
        <property type="protein sequence ID" value="SLM50295"/>
        <property type="gene ID" value="NSJP_4128"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4128"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM50295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="355" mass="38556" checksum="1D785648D29095BC" modified="2017-06-07" version="1">MMGLLVFAVVGTLAWWITGRLAREASFLRSLDHPNERSLHSAPTPRSGGIALLVSILIGLGLAAIGYALVPQSKGFLPKGFASASLWIVGSIALVTVVSFLDDRGGLPVWVRFGAQAAAAAIVVWGVGLRVSSVPIPGVGPVALGWFAAPVSVLFLVWMTNLYNFMDGMDGFAGGMTAIGFGFLAFFGWRSGHPFMLLITSLVAASAAGFLIHNFPPARIFMGDVGSIPLGFTAGALMLLGVRDRLFDIWVPLLIFSPFILDATVTVVRRAWRGARIWEGHREHYYQRLVLSGWSHRRSVLVEYGLMLWCGGLAIVYRGATDRWRMVILFVWMAVFAGLALAVHRRESRADLGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBF0</accession>
    <name>A0A1W1IBF0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_4165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4165"/>
    <dbReference type="EnsemblBacteria" id="SLM50332">
        <property type="protein sequence ID" value="SLM50332"/>
        <property type="gene ID" value="NSJP_4165"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4165"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="206" mass="23423" checksum="8E3E7EFD8B36B7EF" modified="2017-06-07" version="1">MDVQGQRDLLLLSEVERNAHLTQRSLSSRLGVALGLTNLYIKRLARKGYIEIETVPPNRVRYQLTPQGAAEKARLTYEYMDYSLAYYRDIRIRLKEMLISVGRLDGRRFVIFGTGELAELAYLSLREMDGTCVGFLDDERRESFLSYPVCFPEAIGRWEFDKVLIADLDHAPAHEARLIGCGVSPEKIMRLVLTSLRKASADVAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBH8</accession>
    <name>A0A1W1IBH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50123">
        <property type="protein sequence ID" value="SLM50123"/>
        <property type="gene ID" value="NSJP_3956"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3956"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="75" mass="8113" checksum="628807012EAA8740" modified="2017-06-07" version="1">MPPTTVHMDRTATAPTIIPSATARLMSTGKLSFWHIESLLTLHSIDQRVEDDATEMAEGFDARPSSTISALCVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBW0</accession>
    <name>A0A1W1IBW0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4086"/>
    <dbReference type="EnsemblBacteria" id="SLM50253">
        <property type="protein sequence ID" value="SLM50253"/>
        <property type="gene ID" value="NSJP_4086"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4086"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009293">
        <property type="entry name" value="UPF0478"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06103">
        <property type="entry name" value="DUF948"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="135" mass="14260" checksum="2E3E470F9A1D6EB4" modified="2017-06-07" version="1">MNAVEIAAILIAVAFAVLVGYLVPLLIQIRKTVAESEQLLSKMNTDMPALVSELRAMSQNLNDLAEQARGGVEHAAVLLHAVGEVGESVQQVHNVVRGSSGGLLTNVASVVAGLKAATQVVRERYRREGEPHNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZM8</accession>
    <name>A0A1W1HZM8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Tetraacyldisaccharide 4'-kinase</fullName>
            <ecNumber evidence="3 13">2.7.1.130</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Lipid A 4'-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">lpxK</name>
        <name evidence="14" type="ORF">NSJP_0010</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the LpxK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.130" evidence="3 13"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0010"/>
    <dbReference type="EnsemblBacteria" id="SLM46182">
        <property type="protein sequence ID" value="SLM46182"/>
        <property type="gene ID" value="NSJP_0010"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0010"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009029">
        <property type="term" value="F:tetraacyldisaccharide 4'-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00409">
        <property type="entry name" value="LpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003758">
        <property type="entry name" value="LpxK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42724">
        <property type="entry name" value="PTHR42724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02606">
        <property type="entry name" value="LpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00682">
        <property type="entry name" value="lpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 14" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM46182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="352" mass="37958" checksum="5A2D303DACF33FC2" modified="2017-06-07" version="1">MRWWLLWAGWLYGLAGRIRATSYRRGWLARRKLPVPVVSVGNLTVGGTGKTPFVIRLAEGLSREGKRVAILSRGYRRGGAAPRLIVSNGAKVLGTPDEAGDEPYLMARRCPTAVVAVGADRYALGRWVLDQFPVDYVLLDDGFQHLAVQRDVDLLLVDATDFEGLRAVFPAGRLREPIGAAARASMIVVTKADRPEQAAAIADLLQPIIPGVPIAQAVFRPETLVSVADGSPQPLDWCRGKTAVLCSGIADPAAFRALAIRLGMTPVEHMIYRDHHRYTREDVTDVRAKAAAAKTDLILTTEKDAGKLAPLLAPSDGGWWAVRLGTDIVAGERELRELIAKASAGGTGTAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZR9</accession>
    <name>A0A1W1HZR9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiazole synthase</fullName>
            <ecNumber evidence="1">2.8.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.8.1.10" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0050"/>
    <dbReference type="EnsemblBacteria" id="SLM46222">
        <property type="protein sequence ID" value="SLM46222"/>
        <property type="gene ID" value="NSJP_0050"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0050"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34472">
        <property type="entry name" value="PTHR34472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="80" mass="8592" checksum="A892C27830D44953" modified="2017-06-07" version="1">MNQSIHIRVNGEPRGFQSGGTVGDLLRELAITTERVAVELNLEILDRAEFDRRGLQDGDRVEILGFIGGGTGIADAASLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZS9</accession>
    <name>A0A1W1HZS9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">rimM</name>
        <name evidence="5" type="ORF">NSJP_0060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimM family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0060"/>
    <dbReference type="EnsemblBacteria" id="SLM46232">
        <property type="protein sequence ID" value="SLM46232"/>
        <property type="gene ID" value="NSJP_0060"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0060"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="3">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="4">
        <location>
            <begin position="102"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="180" mass="19723" checksum="546DE05F73C1A862" modified="2017-06-07" version="1">MVAAQDDRVTVGRIERPFGVKGEVKVRPLSDVPGRFDRLKSVSVVGAEGLVRNEEVTHVRRAGASYIMRFAGITTPEAAGLLRGTLIQVPPREKGRAAEPADVFYECDLVGMRVEDEGGRALGTIDALWELPGQHIIVVRDGDRELLIPAVKNFVASVDVLGRRMIVRALEELVEDRDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZT0</accession>
    <name>A0A1W1HZT0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Peptidase, M28 family</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0072"/>
    <dbReference type="EnsemblBacteria" id="SLM46244">
        <property type="protein sequence ID" value="SLM46244"/>
        <property type="gene ID" value="NSJP_0072"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0072"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="2">
        <location>
            <begin position="164"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="3">
        <location>
            <begin position="320"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="521" mass="55042" checksum="C24071A750FBBB7F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZW1</accession>
    <name>A0A1W1HZW1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hist_deacetyl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0085"/>
    <dbReference type="EnsemblBacteria" id="SLM46257">
        <property type="protein sequence ID" value="SLM46257"/>
        <property type="gene ID" value="NSJP_0085"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0085"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="2">
        <location>
            <begin position="21"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="314" mass="33781" checksum="54018433999A732F" modified="2017-06-07" version="1">MGKTGLVYHTAYLDHDMGAGHPESPNRLRAIMQQLEYGGTAARLLKIEPRKAEHEWVTQIHGSRYVTALEDRAPSTGRVSLDPDTSMSPGSLAAAYLAAGGVLAGVDAILAAQVDHVFCAVRPPGHHAERDRAMGFCFFNNVAIAARYVQKKHGLAKVLIVDWDVHHGNGTQHSFEDDPTVLFFSTHQYPHYPGTGRATERGRGAGEGFTVNVPMEQGEGDEAYRDAFLKSLVPAADAFKPEFVIISAGFDAHRDDPLAGMGLTEAGYADLTGIVAGIARRHARGRILSSLEGGYHLPALANSVEAHVRALLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZY0</accession>
    <name>A0A1W1HZY0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46305">
        <property type="protein sequence ID" value="SLM46305"/>
        <property type="gene ID" value="NSJP_0133"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0133"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="40" mass="4735" checksum="BCBED65B43E86FB2" modified="2017-06-07" version="1">MGQAIVYGVISLIICVAYFTLVDHFLMDMQGLDYWYLFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I042</accession>
    <name>A0A1W1I042_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0041"/>
    <dbReference type="EnsemblBacteria" id="SLM46213">
        <property type="protein sequence ID" value="SLM46213"/>
        <property type="gene ID" value="NSJP_0041"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0041"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="161"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="336" mass="38756" checksum="E970606FF1FB2146" modified="2017-06-07" version="1">MGRHYAQLSLEDRCTIARARDAGQTIRQIAAALDRAPSTILRELRRNRGQQVGYAPAYAQQQTRSRRWRGSRLLRHPALQVHVLRWLGWGWSPAQVAGRLKRDGGVLRISYESIYRFIASQIRRTKDYRWRHYLPRGKSKRGWRGRKGGSAVDHIRRRVAIGERPAAVQQRQEPGHWEADLMLFAKYGQAVLVTHERRSRVLVASRQPSKAASPVARRLTALFQTLPPALRRTITFDNGTEFAYHYQLHPLGMQTFFCDPHAPWQKGGIENGIGRMRRALPRKTDLATLSTRRLLALVRAYNHTPRKCLDYETPAEVSTRDLLHFKCDSTFPLSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I061</accession>
    <name>A0A1W1I061_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Phosphotransferase</fullName>
            <ecNumber evidence="2">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0214"/>
    <dbReference type="EnsemblBacteria" id="SLM46386">
        <property type="protein sequence ID" value="SLM46386"/>
        <property type="gene ID" value="NSJP_0214"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0214"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="38"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="367" mass="41661" checksum="162AEA297580E731" modified="2017-06-07" version="1">MGTTDPASPQKPLASPDQSRIVEAVETRLPFSRTFKNLTALAGDASNRRYFRVEFNESAPGSLILMQLAEPEAFKHSEEAVSGASHQITELPFLNVRTQLANAGVPVPGLYYYDQTAGLLYLEDFGDLTLSEACRDAPPHRVEMLYRQAVDVLADMQIKATSLADARCLAVHRGFDVPLLMWEFDHFLEYGIAARRGRPVADGEFSEIRDEFRKIAEQLAGQPRVFVHRDYHSRNLMVDGRRLGVIDFQDALMGPATYDLASLLRDAYIALDETLIDRLIGHFLDRLEERGHLRTDRDAFRRLFDFTSIQRNLKAAGRFVYIDQVKGNPKFLADIPRTLGYVKRNLHKYPELKALRRLLSAHVTELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0A4</accession>
    <name>A0A1W1I0A4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">ATP phosphoribosyltransferase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hisZ</name>
        <name evidence="8" type="ORF">NSJP_0263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heteromultimer composed of HisG and HisZ subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0263"/>
    <dbReference type="EnsemblBacteria" id="SLM46435">
        <property type="protein sequence ID" value="SLM46435"/>
        <property type="gene ID" value="NSJP_0263"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0263"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00125">
        <property type="entry name" value="HisZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004517">
        <property type="entry name" value="HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00443">
        <property type="entry name" value="hisZ_biosyn_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="25"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="442" mass="48398" checksum="7D17F5C2567E5610" modified="2017-06-07" version="1">MATILPHAARQVRHLEGQLLAQIGRWGYDEIILPTFEYLDVLAPGLETELLETCYQFIDRTTGRTLLLRPDATAQVARTVAMGLTGARFPQRLAYRTSVFRYEPEHAGRGREIFQIGAELIGLKDVTGDAEVITILIECLQSIGLRSFTIALGHVGFIKGLMARSGLSVRARKRAEQAAARKDLPRLEEILKAERIARSTAMAIREAPELTGRKEVLTRGRALAAGDSALLEPLERLAELYQLLCSAGYEDAVLLDLGEFRGVDYYDGAVFDVFAPGVGAELGGGGRYDHLIGRFGADLPSTGFALDVDRLFRAVAFPEETEGVPRIDYLVIGPQRAMSGVSEVAAQLRRRQFRVAQQIVNKSPRRLLTSAVQQGQAQGARAVVVIGMPGQNRSDEFTVIERAAHRTNPARNGRPSVKKMNLAALIKATQYMPNTPNINGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0L5</accession>
    <name>A0A1W1I0L5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0247"/>
    <dbReference type="EnsemblBacteria" id="SLM46419">
        <property type="protein sequence ID" value="SLM46419"/>
        <property type="gene ID" value="NSJP_0247"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0247"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="70"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="228" mass="26655" checksum="7E4B870B97A03105" modified="2017-06-07" version="1">MMTSSIDRKFDTGYVYTDRQTKAKYVWLKYRDILAGRILDVGADACHLREHLPSETHYCGIGLGGRVDRVVDLERSPLPFPDRSFTSVLCLDVLEHVDNIHAVFDEVCRVSQKYVIVSLPNAWVDFYNMLRRGDYRPDQPMKFYGLPVEPPPDRHKWFFCPEEAERFVRYRAEKNGMRIVQEDYEGTANEGSGWRGMVKTWARRILMRPDLAVKNLYAGTLWVVLERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0P3</accession>
    <name>A0A1W1I0P3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0375"/>
    <dbReference type="EnsemblBacteria" id="SLM46547">
        <property type="protein sequence ID" value="SLM46547"/>
        <property type="gene ID" value="NSJP_0375"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0375"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="22"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="86"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="144" mass="15465" checksum="9AC67F1B5B13AE7E" modified="2017-06-07" version="1">MASTTMEGVPPGGFKTLGEIDATNDLRIHTKKTGMDVALELLATHSSGAPIVDDQGKFMGFVSEFDLLRAIESGKDLNTVTADQIMSTSHFVANESTTIGDAIRIMNEKHLINIPVIKEGQVAYSVTRHDLLRARIGLGPGIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0S5</accession>
    <name>A0A1W1I0S5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">NSJP_0419</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0419"/>
    <dbReference type="EnsemblBacteria" id="SLM46591">
        <property type="protein sequence ID" value="SLM46591"/>
        <property type="gene ID" value="NSJP_0419"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0419"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="347"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="17">
        <location>
            <begin position="425"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="476"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="17">
        <location>
            <begin position="556"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="797"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1042"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="12">
        <location>
            <position position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SLM46591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1163" mass="128328" checksum="B226192F2B8DF8FE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0S7</accession>
    <name>A0A1W1I0S7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46584">
        <property type="protein sequence ID" value="SLM46584"/>
        <property type="gene ID" value="NSJP_0412"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0412"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="134" mass="15660" checksum="B290B9D893451839" modified="2017-06-07" version="1">MTHQPVKPTVPPWLYKLFTGHQYPYVRRLAKFAQPIKPGEDRPEPTKDMIEAKFWEVYPRCSIKVLQEVKVGMIVVFHDLGEYPAGGYQELVDNPEEFLARTYGKKKIKVNFYDGDNFVCTINFKVAGWTEHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0X1</accession>
    <name>A0A1W1I0X1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0452"/>
    <dbReference type="EnsemblBacteria" id="SLM46624">
        <property type="protein sequence ID" value="SLM46624"/>
        <property type="gene ID" value="NSJP_0452"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0452"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021796">
        <property type="entry name" value="DUF3365"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11845">
        <property type="entry name" value="DUF3365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012800051" evidence="2">
        <location>
            <begin position="26"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="215" mass="23812" checksum="6540E3196962B8B1" modified="2017-06-07" version="1">MRRLYWATGFSFAGLLMVAGWTAHAADPSFETTARYILEVVKAFRTAYVLQVVEHIKGTGVSVQEDWEKNAHLLPLPAQFVKGAADQVDGLEIGLIGLAPLNPANRPKTTAEVNALIQLEKNRDKRFVGFMDGDQFKALSADLALVQSCVDCHNRHPRSSRRNFQRWDVMGALVVRFKPDGMTEGLSLPAEPPKRGPGPLERMTPPPTTAPPWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1C1</accession>
    <name>A0A1W1I1C1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46787">
        <property type="protein sequence ID" value="SLM46787"/>
        <property type="gene ID" value="NSJP_0615"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0615"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012144910" evidence="1">
        <location>
            <begin position="25"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="204" mass="21605" checksum="2ADBE6D80444B874" modified="2017-06-07" version="1">MQVTMMLLAIVLLSFVPTVTPAHAQAVAPQCVDEVETHCGHIEPGNLRIQQCFEANINKFSSLCQTELSEGKADAAAGVARARKNKGAPQVDAITLTNDAIVELTDAPGVGRRTTVDLDKRWGADVSVIASATEKLQRALTEAKSGGNARAVHLLEMAVDFGKGSMHKEARLKAQGALLNLCQAAKKTEAPCDTVPKYGAYVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1F8</accession>
    <name>A0A1W1I1F8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46840">
        <property type="protein sequence ID" value="SLM46840"/>
        <property type="gene ID" value="NSJP_0668"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0668"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="172" mass="18863" checksum="E53501DF767F1C56" modified="2017-06-07" version="1">METLSDGLSLRQLLRGFPIPPRRLAAFARGTEFVLQGMPLVADATRILDRVSLQQNGDESFHQIGRLDGEDIMKRLWISVAVVLLGGCGPHYTIPNFESDEIEKVVSSGRSPQACIENLKEDATNLNVKVRLTDMHHEPASGPVAWIYSNAYVCTGKVVKATASSSEEKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1K1</accession>
    <name>A0A1W1I1K1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Homoserine kinase</fullName>
            <ecNumber evidence="1">2.7.1.39</ecNumber>
            <ecNumber evidence="1">3.1.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thrH</name>
        <name evidence="1" type="ORF">NSJP_0703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.39" evidence="1"/>
    <dbReference type="EC" id="3.1.3.3" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0703"/>
    <dbReference type="EnsemblBacteria" id="SLM46875">
        <property type="protein sequence ID" value="SLM46875"/>
        <property type="gene ID" value="NSJP_0703"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0703"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="206" mass="23408" checksum="004631AD944CA5A4" modified="2017-06-07" version="1">MQKPVIACLDLEGVLVPEIWINVAQKTGIEELKITTREMPDYDALMKRRLAILKEHSLAIADIQAVIDKMGPLEGAPAFVAWLRERCQVIILSDTFYQFALPLMRQLDFPTLFCNQLEIDPRGNILAHHMRMPNQKKHSVAAFKSLNFFTMAAGDAYNDTAMLGEADAGFFFRPPDHLPKEFPQFPVTQTYKELQMQFGKAGNLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1K8</accession>
    <name>A0A1W1I1K8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Fumarylacetoacetase</fullName>
            <ecNumber evidence="2">3.7.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0541"/>
    <dbReference type="EnsemblBacteria" id="SLM46713">
        <property type="protein sequence ID" value="SLM46713"/>
        <property type="gene ID" value="NSJP_0541"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0541"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="114"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="328" mass="35481" checksum="19C78DE91E99C440" modified="2017-06-07" version="1">MKLVSFRVSTPVGTFTRVGAMHGRSLVDLNMAYTRWLADHGEAQPHRLANAQVPSSMLAFLEGGTSTMSAARQAMGYAVTLDPSATGPSGETIVYATAGVQIAAPLVDPPSLRDFIAFEDHIAATSKRRGQPIPPEWYKAPVYYKGNHRTIIGPDEDLAWPLNTTMLDYELELACVIGRKGQDIAERDAQHYIAGYTIMNDFSARDVQFQEMACRLGPAKGKDFATALGPCLMTSDEAADLGGLSMVARVNGEEWSRGRFGTIHWSFPQMIAHVSRGETIYPGDIFGSGTVGGGCGLELDRYLKPGDVVELEIQPIGVLRTRIVGATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1N6</accession>
    <name>A0A1W1I1N6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">apgM</name>
        <name evidence="6" type="ORF">NSJP_0748</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0748"/>
    <dbReference type="EnsemblBacteria" id="SLM46920">
        <property type="protein sequence ID" value="SLM46920"/>
        <property type="gene ID" value="NSJP_0748"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0748"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16011">
        <property type="entry name" value="iPGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004456">
        <property type="entry name" value="Pglycerate_mutase_ApgM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042253">
        <property type="entry name" value="Pglycerate_mutase_ApgM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31209">
        <property type="entry name" value="PTHR31209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10143">
        <property type="entry name" value="PhosphMutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="5">
        <location>
            <begin position="2"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="413" mass="44520" checksum="18860D3607726BCE" modified="2017-06-07" version="1">MKYVILHVDGIADQPRTELGGKTPLQAASISHLDDIAQGGEFGVLTVPQENGRHGSGLAGTCILGYEPRKYYQGPGPLEAASLGVTVGEHDVVYRCTMVTLKAEPQPGAKGGAAEIKKLGPHVMMEDATAGLITGEEARELIDAVNEQLGSEIIQFYPGSGHRHLMVWVNGKSRALCTDPQSLVGKPIGDALPAGDGADMLRKLMDASLTILRDHPVNDERREAGLAPANCLWLWGEGRAVTWPSLIERFHVSGAVVSSSDVHRGLGLLAGLDAVDPERLSETDLATRAAVALEELRKREFAYVHVELPDTVVYGTDVKAKVTGIEDIDRELVRPLLQGMAQLGPYRLMVLCDSGGVQQGKPTDGQWFYAFRDSSIQQAANPTRRFTEVDAQASGLSPRDATKFVIRLFSKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1R4</accession>
    <name>A0A1W1I1R4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46948">
        <property type="protein sequence ID" value="SLM46948"/>
        <property type="gene ID" value="NSJP_0776"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0776"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012732210" evidence="1">
        <location>
            <begin position="23"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="160" mass="17133" checksum="02377226F4849963" modified="2017-06-07" version="1">MGKTTMLGVFFGLVMVIAGASAVLAHQAGGVEVGDWETGSVVGQPFKELDVDAELYSVEIGNMKTWYPPTTVIDFKVRPGRPVLLKVTNNGTTEHGFQLTDATTQAAPTAVNAKLVLKPGETKYVGIPTSDLFYATMGNTLNYRCHLHPAHVGGKLVMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1S6</accession>
    <name>A0A1W1I1S6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inhibitor_I42 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46942">
        <property type="protein sequence ID" value="SLM46942"/>
        <property type="gene ID" value="NSJP_0770"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0770"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036331">
        <property type="entry name" value="Chagasin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018990">
        <property type="entry name" value="Prot_inh_I42_chagasin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09394">
        <property type="entry name" value="Inhibitor_I42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141066">
        <property type="entry name" value="SSF141066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor_I42" evidence="1">
        <location>
            <begin position="23"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="116" mass="12732" checksum="60875295E3AF4303" modified="2017-06-07" version="1">MTTSPDEGSHSSNADVKAIQAVVGRPITIHLWEDRTRGEQWVPSYDAASLALLGDEYLRVAGNNAVDNGTRTFEFQPIKPGNVHIIFEKRMGWKFTAEDRRVFSISVSGSGLQGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1X8</accession>
    <name>A0A1W1I1X8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_0822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0822"/>
    <dbReference type="EnsemblBacteria" id="SLM46994">
        <property type="protein sequence ID" value="SLM46994"/>
        <property type="gene ID" value="NSJP_0822"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0822"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012754586" evidence="5">
        <location>
            <begin position="27"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="329" mass="35444" checksum="5164C98C119BDF93" modified="2017-06-07" version="1">MATLLHMGLILLAAVCMSGLPGIAISADPGSSSGTSPSAGPAKRWTRFELSQTGSGGDLQPGKPLTLDITLGGVVQSSVPVVAICESVLFESQTATLDPEGDSMTLKTTVTLEPMPMSRTSVRPKSARIQVSFARFRQDKFERFMRRVVYVTLNQQEPSADSVDPTPTKPEEPAAVELIADEVQPDVIPVTGEALAEEDLMPFADPGQGRAYWQHVSHLVSRSWARQVREMRRGPGGETVRVHFQLFPNGRAQLIEIEKGSGAREIDEAGIYTIINAQPFPPFPNELGDEAVDVHVRMRTGAKPKPRDVQSVTNQSAGRPDAPGGGVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Y2</accession>
    <name>A0A1W1I1Y2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MMPL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_0661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0661"/>
    <dbReference type="EnsemblBacteria" id="SLM46833">
        <property type="protein sequence ID" value="SLM46833"/>
        <property type="gene ID" value="NSJP_0661"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0661"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="633"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="685"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="718"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="157"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="772" mass="82687" checksum="0EA963DEFE87A6DE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I207</accession>
    <name>A0A1W1I207_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0850"/>
    <dbReference type="EnsemblBacteria" id="SLM47022">
        <property type="protein sequence ID" value="SLM47022"/>
        <property type="gene ID" value="NSJP_0850"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0850"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="172"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="273" mass="30616" checksum="1A483E4E10931327" modified="2017-06-07" version="1">MSGDYSPADLCRILGLTDAQLRACLRTALLPGPRTTPPCTYSFQNLVLLRTAKGLTEAGVSSRHIRKVLERLLPQLGEGQALTSLKIYASGKRVVVWDGESRWQPDSGQFVLNFDTAQMLPPVPLPARHDVQSSPSEAARRWFDRAIALEPDSPEEAYRAYEEALRLYPGLVDAQINLGLLHHNAGHLAEAEGWYRRALEQDPTRALTHFNLGVVLEDQQKRKDALAAYEEAVRLAPEFREAHCNLAQLYETLGRQRDALRHYATAKRLPESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I266</accession>
    <name>A0A1W1I266_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">hemL</name>
        <name evidence="9" type="ORF">NSJP_0912</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0912"/>
    <dbReference type="EnsemblBacteria" id="SLM47084">
        <property type="protein sequence ID" value="SLM47084"/>
        <property type="gene ID" value="NSJP_0912"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0912"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="427" mass="45436" checksum="D97F529EB3F52310" modified="2017-06-07" version="1">MKTTRSAKLFERGQQLIPGGVNSPVRAFRSVGGQPRFISRAKGSRLYDVDGNTYIDYVLSWGPMILGHAAPSVIAAVRKAAGRGTSFGAPTELEVSLAEMIREAFPSMEKIRLVSSGTEAVMSAIRVARGFTKRDTILKFEGCYHGHSDYLLAKAGSGLATLGIPDSPGVPEDFAKHTLTAPYNDIGAVRRLVDNHRGRLACIILEPIAGNMGVVPPAPDFLSDLRKLTLEHDILLIFDEVITGFRVAYGGAQSLYGVTPDLTVLGKIIGGGLPVGAYGGRREIMDLIAPSGPVYQAGTLSGNPLAVTAGIATLTKLKGRGVYTGLEARAAAFAKGMGAAAKKAGIPLTQTRVGSMLTSFFTASPVRDWTTVKQSDTQRYGRFFHKMLDQGIYLAPSQFEAVFLSTAHSSAEIDKTLRAASAAFKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2D8</accession>
    <name>A0A1W1I2D8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Energy-dependent translational throttle protein EttA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translational regulatory factor EttA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">yjjK</name>
        <name evidence="7" type="synonym">ettA</name>
        <name evidence="11" type="ORF">NSJP_0985</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">Associates with ribosomes and polysomes.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0985"/>
    <dbReference type="EnsemblBacteria" id="SLM47157">
        <property type="protein sequence ID" value="SLM47157"/>
        <property type="gene ID" value="NSJP_0985"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0985"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00847">
        <property type="entry name" value="EttA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022374">
        <property type="entry name" value="EttA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43858">
        <property type="entry name" value="PTHR43858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03719">
        <property type="entry name" value="ABC_ABC_ChvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="10"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="329"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="PtIM" evidence="7">
        <location>
            <begin position="247"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="361"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM47157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="560" mass="63065" checksum="FDC5C84F38D33527" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2J1</accession>
    <name>A0A1W1I2J1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4412 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47226">
        <property type="protein sequence ID" value="SLM47226"/>
        <property type="gene ID" value="NSJP_1054"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1054"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025524">
        <property type="entry name" value="DUF4412"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14371">
        <property type="entry name" value="DUF4412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012574122" description="DUF4412 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4412" evidence="2">
        <location>
            <begin position="25"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="215" mass="23647" checksum="834FC74DB181801F" modified="2017-06-07" version="1">MKGATIAMLLMLWCGQTTPSLAAAFEGVITLKEIAGEETETRVFYFKGEKMRIDDGDTGFSVWDAKKKDGFFVDRDDQTYTTMSWAEMGVMDPKSILDDITVTKTGKNAKIAGYSCEGYLAKDKSDGSTSELCIAKGLSNAALFGILAADASAGGGYPAWFRDFLKEGGFPLRQIDYDEAGKEESRSEVTKIDAKRLDDRLFHPPAGFKKLELRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2J2</accession>
    <name>A0A1W1I2J2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative S23 ribosomal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47089">
        <property type="protein sequence ID" value="SLM47089"/>
        <property type="gene ID" value="NSJP_0917"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0917"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="105" mass="11512" checksum="3064D45F5D3EE1D6" modified="2017-06-07" version="1">MAKEYATTVYAATAKFPRHEDYGLKSQMNRAANSIGLNIAEGSAQKSNKVFDYHLEIALGSTYEVVAGAFLAKDRVYITEPEHNKICTSIASGLPRVSMHSEILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2L3</accession>
    <name>A0A1W1I2L3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47248">
        <property type="protein sequence ID" value="SLM47248"/>
        <property type="gene ID" value="NSJP_1076"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1076"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013275117" evidence="2">
        <location>
            <begin position="23"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="479" mass="51108" checksum="21CAAFFA267FC1F8" modified="2017-06-07" version="1">MSTFSSVLRATRCLLSSSTAGAVLIAMGVAFEEPASAGTLPMPSCSSSYKKQVVPAKQLRAIVRSHGQWLEERHHPGHRKADLCQADLRQASLAQANLERANLEGAILRQADLSQSTLVQARLAETDLTKAHLEMANLSGADLRRARMSGADLTQVVGDEAAFLGAVLIEARLREAALERAHFEGANLTSADLTGADLVDSHFYGALLHRAILSGADLLEADLRRTDLSKAHMKGTNLQSALFDGAILRGTQLVDADLEGAYFDDADLTEANLQDALLRGADFRFSNLHAANFYRADLEGANLEGARLTGANFRAANLKMAIIYLATADGADFRNARMDRAILIGTTGTGATFVAAELSEAYAPKVSLRNALFNDATLESAYLVSADLRGAEFNRAKLAHANLQEADLRGASFSRADLTGTRLEGANLRDADLRGADLKSAIGLTQAQLESACTDSSTVLPGDLNRPGPCRFPSKKGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2R6</accession>
    <name>A0A1W1I2R6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47169">
        <property type="protein sequence ID" value="SLM47169"/>
        <property type="gene ID" value="NSJP_0997"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0997"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="89" mass="10120" checksum="380969EE67C7A2BA" modified="2017-06-07" version="1">MKGLRFERIGQGRYYNVVFHLGSTYVPVSDETVDELKAQSLLPAERFLDLLLDRVGYSSYLKDQIRSELRSSGDPVTQITVLQGAIREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2X5</accession>
    <name>A0A1W1I2X5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1185"/>
    <dbReference type="EnsemblBacteria" id="SLM47357">
        <property type="protein sequence ID" value="SLM47357"/>
        <property type="gene ID" value="NSJP_1185"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1185"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="131" mass="15207" checksum="7FEE442BA8002746" modified="2017-06-07" version="1">MDSIIPPDIRRFVLDRIDSIAELEALLLLRNSPDTWWEDAAAAQRLYLGAEQGRAVLIRLEAAELLISQDDAPGRRWRYRPQSGDLREMVDRLAYYYTKHLVPVSNLVHDKSKSRIKEFSRAFELPETQDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Y3</accession>
    <name>A0A1W1I2Y3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Permease, MFS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47376">
        <property type="protein sequence ID" value="SLM47376"/>
        <property type="gene ID" value="NSJP_1204"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1204"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="436" mass="45767" checksum="979570DE49CF1452" modified="2017-06-07" version="1">MQDRPAPLTIQGVPRRWLLSHDFSLVWWGQVVSQVGDGISKLALVWFVYSVTGSPLKTSIIGLLQTVPAIVLAPLIGVAVDRLPKKTLLILSDLVRALVIGLIPCWMPVDTFTVSALYVLVTLHAMATAVFGPALTASIPSLVAPAQYTSANALLQVTTSLGIIMGPALSGLGIAALSSQEVLCLNAATYVISAACFIPIRFAPSVSSGASQSLASTWRDVVEGFYYVVRGRPLVLFLTATASLYTFATAAFTTLFPVFARKLLDLGPVEVGYLWSMLGIGLLSVSVVLTTISAWSVKRRLKIIAMASAASGVALLGLVWASRPAAAAGLLILLGGGLGVLTPVAWGVLQEVTPAQLLGRVLGFYTMGAMGAAMGGITFFGWVTGEYGVPISISVIGLVMVGTGLWTGHFLGRMTERSLAYVVQQPVEGEGDTCQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I374</accession>
    <name>A0A1W1I374_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1111"/>
    <dbReference type="EnsemblBacteria" id="SLM47283">
        <property type="protein sequence ID" value="SLM47283"/>
        <property type="gene ID" value="NSJP_1111"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1111"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012845477" evidence="3">
        <location>
            <begin position="39"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="711"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1644" mass="181399" checksum="F7E44F7701F7A467" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I376</accession>
    <name>A0A1W1I376_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47444">
        <property type="protein sequence ID" value="SLM47444"/>
        <property type="gene ID" value="NSJP_1272"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1272"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="58" mass="6748" checksum="6AD8622DE5D2A6E0" modified="2017-06-07" version="1">MFISESFLPVLRYTPTPVSGYVAIQREPNRNKRNLTNLKLVPFPRFPLFSSNSMCFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3D2</accession>
    <name>A0A1W1I3D2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-quinone oxidoreductase, membrane subunit M</fullName>
            <ecNumber evidence="6">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoM</name>
        <name evidence="6" type="ORF">NSJP_1299</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1299"/>
    <dbReference type="EnsemblBacteria" id="SLM47471">
        <property type="protein sequence ID" value="SLM47471"/>
        <property type="gene ID" value="NSJP_1299"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1299"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="5">
        <location>
            <begin position="180"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="562" mass="61776" checksum="B8208FD276EA5345" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3H9</accession>
    <name>A0A1W1I3H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47577">
        <property type="protein sequence ID" value="SLM47577"/>
        <property type="gene ID" value="NSJP_1405"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1405"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="106" mass="12091" checksum="1B83B7047D970086" modified="2017-06-07" version="1">MLENIGDCRCRGNRFDGTLGQSSVVGWKGLQNRLNLTGFSMAYWYASITSMPSIHDERTGRIGRERLRRRGLTGTRPLPIMHRSFANDRRIQGVLGCHLPFNSRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3I8</accession>
    <name>A0A1W1I3I8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1396"/>
    <dbReference type="EnsemblBacteria" id="SLM47568">
        <property type="protein sequence ID" value="SLM47568"/>
        <property type="gene ID" value="NSJP_1396"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1396"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="119" mass="12773" checksum="BE4E341B51D00A54" modified="2017-06-07" version="1">MIKSIAFTMYPAQDLARARDFYERLLGLRPSRDFGGAWIEYDLGGGTFAMSTMAEGVTPSADAGGSIAFEVADVDGLVARLRDQGVRIKVAPFTTPVCRMAVILDSEGNALTLHQATTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3J1</accession>
    <name>A0A1W1I3J1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cofac_haem_bdg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1390"/>
    <dbReference type="EnsemblBacteria" id="SLM47562">
        <property type="protein sequence ID" value="SLM47562"/>
        <property type="gene ID" value="NSJP_1390"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1390"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd14727">
        <property type="entry name" value="ChanN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007314">
        <property type="entry name" value="Cofac_haem-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04187">
        <property type="entry name" value="Cofac_haem_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cofac_haem_bdg" evidence="1">
        <location>
            <begin position="72"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="337" mass="37646" checksum="54CEC9D5664CC422" modified="2017-06-07" version="1">MRSITTTWVLSADGWWRATIGLLLLSWTTACTVAEKKESVHSDEAASALRIGQIIDTATGQALSLEQLGLILRRQEVIYLGEEHHNRFHIDAARGVLDGLISGGRRPVLAMEMFGWDGQAALDQYLGPEGLGREEFLTAVQWKQNWGGSFEDYEPLVQFAKEHHLPLVALNPPKIVVRNVAKQGLEQARRSAEMEQWGMADESIVEDPAYRSRILHQLKACHGGEDAMYQAMYEASMVRDEGMARTISAQVRRIREGSDHAAGPVVSYTGGGHVQYNLPVPKRVLRRLNGDVRQVSIYMTSFEGSRTEEIREVLGEKIADYVWLTAVSPQGAPHRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3P0</accession>
    <name>A0A1W1I3P0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47612">
        <property type="protein sequence ID" value="SLM47612"/>
        <property type="gene ID" value="NSJP_1440"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1440"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="51"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="167" mass="18912" checksum="B81863F0DD34D57B" modified="2017-06-07" version="1">MLAAASWHLLEQRALRLKGLLAGNAVSPASVPSGITSQFRQQPYVIDFYADRLEDAILIRNTDGTIQGWNQGAKRLYGWDANETVGKTSHFLLKTIFPCSLSSIETQLVQRGFWEGKLIHKCRDGAQLVVHSKWLLLHEVENSDAVVYEVNSQKVQMDKHWKEAYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3S7</accession>
    <name>A0A1W1I3S7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1321"/>
    <dbReference type="EnsemblBacteria" id="SLM47493">
        <property type="protein sequence ID" value="SLM47493"/>
        <property type="gene ID" value="NSJP_1321"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1321"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020948">
        <property type="entry name" value="P_starv_induced_PsiE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06146">
        <property type="entry name" value="PsiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="158" mass="17850" checksum="E6E302A89CA75E17" modified="2017-06-07" version="1">MKDRREVMNRWCGVMEWLDRLGYMTAGFSLLVLGMLLFAHAWYVFATKAGQIGLLPSGLKLLNDILLVIILLELFRTVIRFLQTEVLDLEPYLAVGIIACTRRVLTASAELSHLPSMSEGQFYQYLMDVGLNVMVIMVLVIGVFLMRKRPVPSSVPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3T5</accession>
    <name>A0A1W1I3T5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trypsin-like serine peptidase, S1C</fullName>
            <ecNumber evidence="4">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.-" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1496"/>
    <dbReference type="EnsemblBacteria" id="SLM47668">
        <property type="protein sequence ID" value="SLM47668"/>
        <property type="gene ID" value="NSJP_1496"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1496"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012912918" evidence="2">
        <location>
            <begin position="32"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="251"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="351" mass="36343" checksum="150678591D50A3B7" modified="2017-06-07" version="1">MMRVMTLFHKSCRLCFLLCVFGVMSNSPSWGDPGSAPVSASDKTLSVPAVVAKVRPSVVTILTRGAPAASPTQSQSGSGSGVIIDEGGYILTNNHLVTGSKSIVVGLSTGRMTPGRVVARDFLLDLALVKINAQDLVPAALSPSPTLEIGESVVAIGNPLKGGSTVTVGVVSALDRSVLTPDGETLYDLIQTDAAINPGNSGGPLVDLSGRVIGINVAIAPSAQAISYAISMDAIYPHIQSMIVRGSIYRPDLGFVPVTVTPSIMATFGLDGDRGVLALEVDGTKPAAIGGLQDHDIITAVDQRQIFNTGDFWHALLRSGDQPTVQLTLHGKSGPATLELPKPPAPIRTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I407</accession>
    <name>A0A1W1I407_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Outer membrane lipoprotein carrier protein LolA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1585"/>
    <dbReference type="EnsemblBacteria" id="SLM47757">
        <property type="protein sequence ID" value="SLM47757"/>
        <property type="gene ID" value="NSJP_1585"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1585"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd16325">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004564">
        <property type="entry name" value="OM_lipoprot_carrier_LolA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35869">
        <property type="entry name" value="PTHR35869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03548">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012393411" evidence="1">
        <location>
            <begin position="23"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="236" mass="26507" checksum="05B7A6479E27FCD4" modified="2017-06-07" version="1">MRRIIVMAMAVCLLAGPCLVSAEEPADPQERKEIQDIVKRLQARYEKTKDLQADFTQKTTIEGFERPMLSTGKVYIKKPGRLRWNYLDPSTEDIYVNRDDVKVYVPEHKQVLVGKLTQMAASRAPLELLQGAAKLEESFVVEPTPGKAKGLGGLRLLTLLPKGEGHETVRSLQRIVIEVFPKTYFIRTISLHEHSGNVSYFEFSSLQDNVGLGDEVFEPKFPADVEVVKAPVLSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I411</accession>
    <name>A0A1W1I411_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1519"/>
    <dbReference type="EnsemblBacteria" id="SLM47691">
        <property type="protein sequence ID" value="SLM47691"/>
        <property type="gene ID" value="NSJP_1519"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1519"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031321">
        <property type="entry name" value="UCP012641"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15887">
        <property type="entry name" value="Peptidase_Mx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="372" mass="43971" checksum="DB164633A0748779" modified="2017-06-07" version="1">MAWPGLLYFICHSRNPAVGLAKIDDKGNMNQHSGRTEPLWATWGDERLLDLPIRRLGVNLHSPFLTAQIERLHQELEAKRLRFRPHCWLSNEWFTPDGVPGIAIPFYLAHPRLIKLELNQMLEVEGGTSEWCMRILRHEAGHAIENAYRIRRLHSRQRIFGRSSEPYPKYYSPRPYSRSYVRHLDLWYAQSHPDEDFAETFAVWLTPDSMWADRYKGWPVLRKLHYMDGLMRDLEGVAPKVTTTETVDPVHSLKRTLREHYDRKRVHYGIERPSSYDPDLKRLFSETSLHADRTSAAVFLKRFRREVRRKVAGWTGEYQYTIDQVLEDMILRCQELRLRVPSPEEQVKLDFTILLTMHTMNYLRSGRHKVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I419</accession>
    <name>A0A1W1I419_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ca2+/Na+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_1578</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1578"/>
    <dbReference type="EnsemblBacteria" id="SLM47750">
        <property type="protein sequence ID" value="SLM47750"/>
        <property type="gene ID" value="NSJP_1578"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1578"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="8"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="198"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="335" mass="35631" checksum="5154811AFA2D6453" modified="2017-06-07" version="1">MNLALYGLLFVASVVVTLGACALFTNAIEWLGKRLNLSEGAVGSVLAAIGTTLPETSIPIVAIFFGGTREEAEVGLGAILGAPFMLSTLVIPILALLLVLYAGLGKRNAVFRLNYKDVSVDLAFFAAAYAVALGCVFAPAPVHVAAAVGLIAWYLYYVKLKFTETGDEEEGELNELGALFFSRRADTPSYGMIVLQALTGLGGLVIGAHMFVTAAESTAQYLSISPLILALLIAPLATELPEMSNSFLWLYQKKDRLAVGNVTGAMVFQGTIPVSVGLLGTEWALAPSALLTMMLAVLATLTLLFQSAVGRTWRPWLMSACALLYIGYAVYLYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I428</accession>
    <name>A0A1W1I428_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47760">
        <property type="protein sequence ID" value="SLM47760"/>
        <property type="gene ID" value="NSJP_1588"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1588"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="81" mass="8379" checksum="A3C79D932B1BC271" modified="2017-06-07" version="1">MTFGSCPSEATLSPRAHADEAACAAKGARPFIVDARMARPARITVADYSSLAAEELYGSADVSALGPGRTIPRQCHDGISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4P3</accession>
    <name>A0A1W1I4P3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP citrate lyase, alpha subunit</fullName>
            <ecNumber evidence="10">2.3.3.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aclA</name>
        <name evidence="10" type="ORF">NSJP_1800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1800"/>
    <dbReference type="EnsemblBacteria" id="SLM47972">
        <property type="protein sequence ID" value="SLM47972"/>
        <property type="gene ID" value="NSJP_1800"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1800"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA_binding" evidence="9">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Ligase_CoA" evidence="8">
        <location>
            <begin position="175"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="606" mass="65293" checksum="A4345585B825E2F2" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Q5</accession>
    <name>A0A1W1I4Q5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47982">
        <property type="protein sequence ID" value="SLM47982"/>
        <property type="gene ID" value="NSJP_1810"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1810"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="PTHR31851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="322" mass="35030" checksum="CD13C897265CAFBF" modified="2017-06-07" version="1">MTDPRVSHDLSLARTLILDELFDLSLYRKLRDITRDPDAQRILDALIAVEVDHLAFWKRFFAMDIEHLDVRRSIKLRLLTLTCRLFGVTAVHLVLEAIEVHGVRKYLTLWTQFHGQSLGAALHDILMDEFKHEDVLVTSLTERKINAEKIRNIFLGLNDGLVEILGAVSGFFGAFGSASLVLIASSTTAVAGALSMAAGAFLALNSEQEVRATESAKKRFLGEISESTVMAEPPLASAAFVGIAYLIGATIPVFPVLLGADTAVFSVITAGLMVVIISTILSFLSGMDITRRILLNLAIITVAVSVSYGIGLLAKRIWGIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4R0</accession>
    <name>A0A1W1I4R0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47986">
        <property type="protein sequence ID" value="SLM47986"/>
        <property type="gene ID" value="NSJP_1814"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1814"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="105" mass="11637" checksum="A0D57D1476122362" modified="2017-06-07" version="1">MLKSAGYDVLESCDGLDALDHLRNMPSPPALVLTDVMMPRMTGPQLAVQIEAMMPGVRLLYMSGYSDQILGPLDGTLRSFIAKPFRRQHLILRIREALLGRSEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4S4</accession>
    <name>A0A1W1I4S4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_1855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48027">
        <property type="protein sequence ID" value="SLM48027"/>
        <property type="gene ID" value="NSJP_1855"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1855"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="73"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="207" mass="22230" checksum="81F9FDED14447BAD" modified="2017-06-07" version="1">MSEVVKLQLIGLSVVGLGIVILLFVRAQFARVIGFVAIVLGLFSLVALAVPQMASLPPAEEKFDIATVKTPTDMAAIGQKIFFSKGQCALCHSIGPSESARCPDLKGIGAKLSREFIFESLTQPQAYIYLDYRHEGLPKEYPARMPYINKNPIGLTKNEILSVIAFLQQMSGEPISVNPSELEVPGQTPAAPVKAAESNPVAVAKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5C3</accession>
    <name>A0A1W1I5C3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8 10">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_2046</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Magnesium. Can also use manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the ApbE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="2 8 10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2046"/>
    <dbReference type="EnsemblBacteria" id="SLM48218">
        <property type="protein sequence ID" value="SLM48218"/>
        <property type="gene ID" value="NSJP_2046"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2046"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006268">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010598266" description="FAD:protein FMN transferase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006268-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="349" mass="38077" checksum="0FAD7EC3173AD789" modified="2017-06-07" version="1">MLAIAMASAVLISGCSAFPKDNQSITVTRTQMHMGTLVTITAAAPTESVALAASTEGFSEIHRLDVLLSTWISSSELSAVNAAAGKAPVRVSSDTLQIVKLALRVAELTDGAFNIAIGPAVDLWNVMERQDVPTVEELEHVRDQIVLSGVRIDNAERTIFLERAGMRIDVGGIAKGYAADRAVMRMKKAGATGGIVALSGDIKAFGRLPKEKRATVGIQHPRMPEELLLVIDLDDEAISTAGDYERYFERDGVRYHHILDPATLQPAKECQSVSIIAKEGVWADGLDTGIFVLGPERGMRLIERLGDVQAIIVDREGKVHMSAELRKRVRLHLGEEEQPWQQDTVLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5D3</accession>
    <name>A0A1W1I5D3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Heavy metal efflux system, membrane fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2056"/>
    <dbReference type="EnsemblBacteria" id="SLM48228">
        <property type="protein sequence ID" value="SLM48228"/>
        <property type="gene ID" value="NSJP_2056"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2056"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012596660" evidence="2">
        <location>
            <begin position="22"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="75"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="397" mass="43767" checksum="791481791F92A41A" modified="2017-06-07" version="1">MCIQPRHGRFLLLGWVLASLAAASTGCDSTPSDAVRLKPVVAPAAGVVVLSPEDSSRVGLIVQQVSRSEFRTHRDFPAIVQPNQRAVADITTLVRGRVVDVYADLGQQVEANALLAILYSSELGLAQSAYLKSQAKLHVAEQAYARAKFLLQEKVIGEAEAQRRKAELLSMQAEANEARDHLKLLGMNDGEFRRLDQTRTIRSHVPIVAPFAGRIIGRNLTRGEVVETTEKLFVVADLSEVWVRANIPEKDIPFVHVVHASGGTHADVRVNAYPNEVFKGTITYVGDVLDPATRTMQLRLELPNPEGRLKPEMFATIRLYSEPQPDRLALPESALQRDHDRTFVFVRRSENEYEARDVQIGESNGALTTILSGLSEGDPVVTQGAFVLKSELLKKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5H8</accession>
    <name>A0A1W1I5H8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48250">
        <property type="protein sequence ID" value="SLM48250"/>
        <property type="gene ID" value="NSJP_2078"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2078"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="75" mass="8442" checksum="D41C4A5AD4C5F010" modified="2017-06-07" version="1">MFRDRLGRLGRPRHPPHGTGFRVYATIRSIRSGVDQEKAEAGVGAYSKEHMAKAGLKDCAYLISRLRYMPYAICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5K9</accession>
    <name>A0A1W1I5K9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 7 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">pgk</name>
        <name evidence="11" type="ORF">NSJP_2114</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 7 10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2114"/>
    <dbReference type="EnsemblBacteria" id="SLM48286">
        <property type="protein sequence ID" value="SLM48286"/>
        <property type="gene ID" value="NSJP_2114"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2114"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="23"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="353"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="399" mass="42537" checksum="646FFB11B1035096" modified="2017-06-07" version="1">MNLHKQTIDDLTLAGKRVIIRADFNVPLDDSLQITDDTRIRSTLPTINRVVDDGGKVILCSHLGRPKSRFDPKYSLAPIAKRLGRLLGKNVIFAPDCVGPAVEGLVAKMSPGDVMLLENLRFHEGEEKNDESFSKALAALGDVYINDAFGAAHRAHASTVGITKFIPASAAGFLLKKEIEYLEGAVANPVRPFVAILGGAKVSGKIGVIENLGKRVDKVIIGGGMAFTFLKAKGLEIGNSLVENDMLDFAKGIEDHAFSRGVKFYLPVDCVVAASREPGAETKIVPVQEIPKGWYALDIGPASVKLFREAVQNAKTILWNGPMGVFEIDAYARGTLSVAHAVADAYALTIVGGGETAMAIHRAGESENISFISTGGGAALELLEGKQLPGLTALPERKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5S5</accession>
    <name>A0A1W1I5S5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48356">
        <property type="protein sequence ID" value="SLM48356"/>
        <property type="gene ID" value="NSJP_2184"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2184"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="70"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="155" mass="16573" checksum="F8FE6E605BE9AA06" modified="2017-06-07" version="1">MQTWRSSGLMMMTLGGFILLAPVSTPRAEEDGKGAIVEGAGFTLYDMESIKGSDAEKLDKDPVCDRNKRPRIAKVEPDEAMPGDKVVISGENFGTKECFHTVTFSASPKAPVEYKFVNDTTIEATVPDAKAGMSFLIIVAGGGSAQSKPLLIKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5T0</accession>
    <name>A0A1W1I5T0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48367">
        <property type="protein sequence ID" value="SLM48367"/>
        <property type="gene ID" value="NSJP_2195"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2195"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="137" mass="15406" checksum="25B997C00FAFE657" modified="2017-06-07" version="1">MATDNKLTVLEVTGPFREPREPVFSYDYAVQRVSWSMPHAVRVKVAIAEELDVIKGRLLGQVTGSPGQHLLIARALSRRIADEKLKIAEAEGTLSDRRDVVIEPFTGQQAHLFAQLDEWFERERQVLLAEVKARAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I610</accession>
    <name>A0A1W1I610_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48434">
        <property type="protein sequence ID" value="SLM48434"/>
        <property type="gene ID" value="NSJP_2262"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2262"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="94" mass="10761" checksum="FA9477E12D3B0849" modified="2017-06-07" version="1">MGTRVKITDPEKLALLYERFRDVCLVEKEVWKEIFMPREVSQGPVRTNIQDRYDVEIDDPAVEDTLDANISLGGAALGAAIQEYRQHIGFYRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I667</accession>
    <name>A0A1W1I667_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpmC</name>
        <name evidence="6" type="ORF">NSJP_2346</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2346"/>
    <dbReference type="EnsemblBacteria" id="SLM48518">
        <property type="protein sequence ID" value="SLM48518"/>
        <property type="gene ID" value="NSJP_2346"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2346"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="69" mass="7954" checksum="0707A6F46608F069" modified="2017-06-07" version="1">MDLKELKQLSAPELSEKAKELTQELFNLRFQLGTGRLENPMQIRKTKRTIAQVKTLLRETERASQKPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6I0</accession>
    <name>A0A1W1I6I0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2422"/>
    <dbReference type="EnsemblBacteria" id="SLM48594">
        <property type="protein sequence ID" value="SLM48594"/>
        <property type="gene ID" value="NSJP_2422"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2422"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021866">
        <property type="entry name" value="SpoIIAA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038396">
        <property type="entry name" value="SpoIIAA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11964">
        <property type="entry name" value="SpoIIAA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="120" mass="13243" checksum="B926342241D5A332" modified="2017-06-07" version="1">MLVHQLLANEGILLIRPDGPIAAGDFELVAKTVDPYIENKGTLRGVMIEAPSFPGWDSFAALMSHLCFVRDHHRFVAKVAAVSDSPILSIAPEIAKHFVQAEVRHFNATDRDAALAWLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6W1</accession>
    <name>A0A1W1I6W1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48734">
        <property type="protein sequence ID" value="SLM48734"/>
        <property type="gene ID" value="NSJP_2567"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2567"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="193" mass="21853" checksum="1C4A08BC3C3F4E65" modified="2017-06-07" version="1">MREAQSTRMPGAMMALGSMVAVLTLTACESTPKWVKTGVYTGSDAKAFYSTGEVMGIRNEPLAWDVAENRARAQMVKILSTYTAYLMRDYAASTVGSDFKRTAEEQHVEEATKTFAAATLNGVRPVDRYKDEKKGIYYVVVKMELEDVKDMIVQSKELNGQMRDYVRKNADRAFERLEKEEQKREAPVQKPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6W9</accession>
    <name>A0A1W1I6W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lcfA</name>
        <name evidence="3" type="ORF">NSJP_2595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2595"/>
    <dbReference type="EnsemblBacteria" id="SLM48762">
        <property type="protein sequence ID" value="SLM48762"/>
        <property type="gene ID" value="NSJP_2595"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2595"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="32"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="460"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="552" mass="61014" checksum="4E8BC246834573DE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I744</accession>
    <name>A0A1W1I744_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48827">
        <property type="protein sequence ID" value="SLM48827"/>
        <property type="gene ID" value="NSJP_2660"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2660"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012144913" evidence="1">
        <location>
            <begin position="21"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="335" mass="36893" checksum="BB475D62B02417CE" modified="2017-06-07" version="1">MSSAFIVLFVSLCMLSPAWASGGHNAHDHHAVPTLANQVTTTVTIEDDLVRLTFGPIDLPSAHDGDLAASMPKHVFQLPKDMYMVGFKSEVFTKDGTQLPRNYLHHILMLNNDKPSVSCPGEPLFFGGAGLEMTEAKFPDGYGVKLAKGQNLMSVVAFYHKAPPTRDVMASFTMYMARDGASVKEMDVYQVGVNVVCYSKFSQRGADQTDEGIEIKPGVQVHAAPLKFSMDGCVKFAYPHGHDELLLIALENKTRKETLLRTVPDVSMDGTFLEFPPHQVYKNGQGFAVTKSDDYEMVMVHHHPLQKKEDQHGMGNYLLYMTPGACPGPSTAQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7A7</accession>
    <name>A0A1W1I7A7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48693">
        <property type="protein sequence ID" value="SLM48693"/>
        <property type="gene ID" value="NSJP_2526"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2526"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="294" mass="32282" checksum="A36E012413217DCE" modified="2017-06-07" version="1">MPDTDFHPDKDSEELARKLASIGVEDIRRSGEPSYASDALPVFLEMHARELGIEAPMRDVAYVMQEFAWQWGLGREFGRMPCVRIASGEQSEIVPLSLPFDFPFPRGVRPWPWLRRLYPFPPGFLFEAYEDFLRSRGDSEGISIESVDYVLERLRNGLASFLAYRIAGFRDWAMGKEKGGQGNLGGKGGKRARGKGGGGQGGSGSGGPLPPASLSSGGGMGVEMWCTSPGLTIEFSHAYFIHFLNFGAPSFPVSNTLLGGRYVFQGKGPTYPSGTVRSQVFRIPPDYKAVTTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7A8</accession>
    <name>A0A1W1I7A8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48928">
        <property type="protein sequence ID" value="SLM48928"/>
        <property type="gene ID" value="NSJP_2761"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2761"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012980888" evidence="2">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="91" mass="9324" checksum="DDCC5DAC5591312B" modified="2017-06-07" version="1">MRHTGLGIAAALLGLVAFASPALAGETSATMEKMKGEAKATTEEVKGQTKGAVEDAKGNKMSAEAERAKGNAKGSMERAKGEANAMKEKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7J2</accession>
    <name>A0A1W1I7J2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48891">
        <property type="protein sequence ID" value="SLM48891"/>
        <property type="gene ID" value="NSJP_2724"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2724"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="313" mass="34010" checksum="39A1A76D551DF307" modified="2017-06-07" version="1">MRTMITVPFMGTRWILGIGLVIAAAGLPGCAALMGEKTTFNQGGAKVGLERDPTIARAKTDVHNAHPANLTGAEVRTLLGAVEVSGWTGTIVGIFENPRPVPLLTEEQLNAYAGPISDAFRQAGPAERVTFSFPKPDVKYSDNRTIGFLFVRDKYLHIVLTDHASLTRADTGGDELKDPRDTKGMKLWVALPARAAVVPDIQEPTWAAFETVHVSLNMQEVIALRSAKPPVLVGRESAVPPSPVASDAGPSKQDLQNQVRELTNSNLELRGRLDDQAKQMKTLNDEMNRLRLEMDQAKPPKSPPRKSPAPFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7K3</accession>
    <name>A0A1W1I7K3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48965">
        <property type="protein sequence ID" value="SLM48965"/>
        <property type="gene ID" value="NSJP_2798"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2798"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="76" mass="7901" checksum="D7306881D050A07C" modified="2017-06-07" version="1">MSTVPFIRQRVTFNVSGALLFPEADEAVTVTFEEPAGVPVAGAPPVELSGGGEEESLPPQPAVAITTSSSNPVHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7K9</accession>
    <name>A0A1W1I7K9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48849">
        <property type="protein sequence ID" value="SLM48849"/>
        <property type="gene ID" value="NSJP_2682"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2682"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="68" mass="7193" checksum="6735C1904EE43E81" modified="2017-06-07" version="1">MYGFTYTPCISLGLLKEEVGAPIDLLADRSYLLAHHCGDGRGESVCVVSTAPALRLEHQYGGPALSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7P1</accession>
    <name>A0A1W1I7P1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe2+-dicitrate sensor, membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2712"/>
    <dbReference type="EnsemblBacteria" id="SLM48879">
        <property type="protein sequence ID" value="SLM48879"/>
        <property type="gene ID" value="NSJP_2712"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2712"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032623">
        <property type="entry name" value="FecR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16220">
        <property type="entry name" value="DUF4880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4880" evidence="2">
        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="1">
        <location>
            <begin position="123"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="333" mass="37047" checksum="3AECC3DCBB760A4F" modified="2017-06-07" version="1">MSEPQEPQLKNLGTPDERLSRIARDWVIRLASGHMSEAELRRFKQWLAEHPSHQRVFDDERVFWQQLEPLKTVIPANHKTEQLSISRKQRLRPHWRVVITGAVAAGLAGLLFYQDIRLFLSADHRTATGQQQIVQLPDGGLAHLNTDTAIAVSYTEHERRIEILKGEAFFEVVPNRQAPFRVLTQGGITQAVGTAFAVHAQDRQATVTVTEGTVDVATKVTGKDQPASVTVHKDQETLYRVGEAPRAAMAIDGRSALSWIRGGIVIDKKPFAEAMAELNRYRPGRIVVLADPARTKLVSGRFILQGLDDAVTALAKTQGLTVVRLTPYLVLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7T2</accession>
    <name>A0A1W1I7T2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2899"/>
    <dbReference type="EnsemblBacteria" id="SLM49066">
        <property type="protein sequence ID" value="SLM49066"/>
        <property type="gene ID" value="NSJP_2899"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2899"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025738">
        <property type="entry name" value="BatD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40940">
        <property type="entry name" value="PTHR40940"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="449" mass="49952" checksum="7D596CDDFD8F4993" modified="2017-06-07" version="1">MMLPLMLLVCLLPGYVFAGDGAQWMVRARLEPSGPVVVGQPVQLVVDVLVTTWFAGAPQFPALDVPGALATLSDDQPAHLTEDIQGTRWFGISRIYRITPMEPREYAIPRLQILVHPGLVEKPVRLWTPARKLHARVPPGAEGMAQFFATTHLDVSQRFDRRLDGLRVGDAFTRTLTLTADGMPGMFLPPLSFAEVDGLAVYSKAPVVENLSKDRQGFVAGRRTESATYTIQRAGHYRLPEVTVQWWDSVGKKVRGETIPSVTFDVAAISGYRPEIAIPEEVAAAGATRAEEALKPSRVWMVGLVGLLMVLGWLWPRLKRYGAQWAEHRAIQRRIYESSEAAAFARLSSAAEGNDDEGTVRSLYRWLDRCEPVGKPALAERAIDLAGDDQYRLATETLFDRRFGSTPPSPDHSIRDLERALTRVRTRLSEDHAMFRRQSDNSLPPLNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Z5</accession>
    <name>A0A1W1I7Z5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2812"/>
    <dbReference type="EnsemblBacteria" id="SLM48979">
        <property type="protein sequence ID" value="SLM48979"/>
        <property type="gene ID" value="NSJP_2812"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2812"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="72" mass="8148" checksum="C1B96B1F1E97236D" modified="2017-06-07" version="1">MRCFEMAVVKMAQALTAKKIKELAAGQVVEVVSDDEGIKKDMPAWWVRYSTDQFAPKGISVEWWWRCASAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Z6</accession>
    <name>A0A1W1I7Z6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Outer membrane protein transport protein (OMPP1/FadL/TodX)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_2874</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OmpP1/FadL family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2874"/>
    <dbReference type="EnsemblBacteria" id="SLM49041">
        <property type="protein sequence ID" value="SLM49041"/>
        <property type="gene ID" value="NSJP_2874"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2874"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005017">
        <property type="entry name" value="OMPP1/FadL/TodX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35093">
        <property type="entry name" value="PTHR35093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03349">
        <property type="entry name" value="Toluene_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="435" mass="46395" checksum="32BED455A51E5F31" modified="2017-06-07" version="1">MAKYRHAVSCVARVVCLVVLLSESETWAGGLSLYEIATADVGLASAGWAARAQDPATLLKNPAGMSRLTGNQFQAGAQLLQAGIGFSPSAGTTVDGNSGGNPVGVLPSMSLFYVHGLGEDVKVGLGVFSNFGLGMSYNSGWVGRYYAQENTLIGISIMPGLSYRINDKFSIGAAANVMIGYLNYSAAVNNRAFLNVPDGNMQMTDTTVGAGGNVGILFEPRTGTRFGVTYYSQIKLNFGATPTFTNLTGPLGTALQNNGLLNRTLDLGMTVPQSVMVSSYHEFTDRWAMMLDFGWQDWSQFGKVDVGVTGGNATPSLTTAINYQDTFHVALGNRYRLAEAWLLNSGFAWDSSMLKDQDRTVTLPIGQQFRFGLGAEWQANPKLNVAFSYELAYGGDLPVNQNRGPLAGAVVGQFPGTYINFFQVSFIWGKGAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I846</accession>
    <name>A0A1W1I846_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49174">
        <property type="protein sequence ID" value="SLM49174"/>
        <property type="gene ID" value="NSJP_3007"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3007"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="75" mass="8527" checksum="79CB8EBCCF736559" modified="2017-06-07" version="1">MSEIHVAFCCEVCRKVKDEHLVEVAGHEWCSISEYAKRHLVHAEDILLSHTYCPDCTTSYERLMLYGRGSIAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8C7</accession>
    <name>A0A1W1I8C7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Acriflavine resistance protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3089"/>
    <dbReference type="EnsemblBacteria" id="SLM49256">
        <property type="protein sequence ID" value="SLM49256"/>
        <property type="gene ID" value="NSJP_3089"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3089"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="77"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="397" mass="43118" checksum="E4D36C671AB979B3" modified="2017-06-07" version="1">MNIGTGDAPEGDDNRHAAAGSLLIFSVCAALLFLISCGRADQPPHSNAAIPPKAAPHPTDLGPRVEIGTVEMGSGEHDLTLSGKVAYGEDRYSRISSPLQGRVVEVRAHLGDRVKAGDIVLVVDSPDIAQAYSEYVKEDSDLQYAVRAHELAKDLYENKALPLKDLKQAENELVKARAEFRRAKERLLSLRIPQEELNKPVDKQTITSRFEMKSPLTGIVVERAVTPGQSVGGDPSQILFTVADLAMLQVVADVYERDLALVKEGQYAKVMVEAYPGVAFPATVAAIGDVVDPTTRTIKLRAWVNNQENKLKPEMFARLVLRVGGTTPLLTIPREAVLEAEGKQFVYLVEGENQYVKREVTVTPISSDQVRVVEGLASGQRIVIKGAVLIKGQEAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8D2</accession>
    <name>A0A1W1I8D2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cinA</name>
        <name evidence="3" type="ORF">NSJP_2952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CinA family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2952"/>
    <dbReference type="EnsemblBacteria" id="SLM49119">
        <property type="protein sequence ID" value="SLM49119"/>
        <property type="gene ID" value="NSJP_2952"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2952"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00226_B">
        <property type="entry name" value="CinA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008135">
        <property type="entry name" value="Competence-induced_CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006728">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00200">
        <property type="entry name" value="cinA_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="2">
        <location>
            <begin position="14"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="431" mass="45722" checksum="F4EE6D5B24562F0F" modified="2017-06-07" version="1">MPPRRPVRSLLLAETIAIGSELLVGGRTDSNSLRIAEEFGRLGIGVRFKSIVGDDRQDIRTAVATAAGRVGVIVLTGGLGPTVDDCTREAISDATGRRLALRKDAFEALKTRLAEWGRVPNAGQRRQALIPDGATVIANPVGSAPGFWMKWKGALLISLPGVPWEMEAMLRDSVAPVLSSELTRARLRPSPITRLVFHTFGLPEAEVDAKIKGLVKPSMPVDLGLLASPTGVLVSLTTRPRPVLSGPRLQRLADGVRSRLRDQLYAEGLETMEEVVGRLLTAQHKTVAVAESCTGGLIGHRLTQVPGSSAYVDRGVVCYSNQAKTDLLGVPPALIEGHGAVSAEVAAAMARGMRERSGVSVALSVTGIAGPGGGTPTKPVGLVYLGLDAEGGPSATREYRFSGDRMVVKQRASQAALDLLRRWLLERAEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8M0</accession>
    <name>A0A1W1I8M0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="8 9">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">miaB</name>
        <name evidence="13" type="ORF">NSJP_3187</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="8 9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3187"/>
    <dbReference type="EnsemblBacteria" id="SLM49354">
        <property type="protein sequence ID" value="SLM49354"/>
        <property type="gene ID" value="NSJP_3187"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3187"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="7"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="150"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="381"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM49354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="455" mass="51152" checksum="DBA973D46837FAE5" modified="2017-06-07" version="1">MSRQQPPQVHLETFGCQMNEYDSELVRSLLTRDGFVFTDDRERADVILMNTCAIRENAHNKVYTHLSDLRALKRQRPLVVGVLGCMAQNLKEELAEKEPLVDVLAGPDSYRHLPELITKAMESQEQGELRRQMAVDLSEYETYDDVAPDRRDGVNAWIAVMRGCDNFCSFCVVPYTRGRERSREPEGIVAEARLAAAEGFKQITLLGQNVNSYRCGDWDFARLLVAVADVPGIERVRFTSPHPKDFPPSLLDAVVSHPKICKHIHLPVQSGNDRILGLMNRTYSRSAYLSLVDQIRSSAPDIVLTTDVIAGFCSESDEEFSDTYRLLEEVRYHAAFIFKYSERKNTIAARKWPDDVPETVKSERVTALADLQRRISHERNRAYLGTTLSVLVEGDAKRSSLQSKGKSDGNITVVWSKESVPADPGQMVRLSVYDCSASTLYAASTGDRACRPKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8M1</accession>
    <name>A0A1W1I8M1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49356">
        <property type="protein sequence ID" value="SLM49356"/>
        <property type="gene ID" value="NSJP_3189"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3189"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012190346" evidence="1">
        <location>
            <begin position="24"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="135" mass="15691" checksum="B232ED988BFA7064" modified="2017-06-07" version="1">MITSPRTLFILVCFMLVFSAAGASTKELLPNEPDLSTRIDELYDHEARMFLMLYSLSGNGQVDYVTGRMVQEYARSNYGNPVYQTEAYPLFYWWNHTMWNDPEQDGVNGNERVYQENVEFDISRYKPCAFNGQPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8M7</accession>
    <name>A0A1W1I8M7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49219">
        <property type="protein sequence ID" value="SLM49219"/>
        <property type="gene ID" value="NSJP_3052"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3052"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="69" mass="7870" checksum="A7CD485813921147" modified="2017-06-07" version="1">MLGQCPIEDRLIGPSVCHLSLRPIDRWTLEFPLDDNPCLLSVSPGDSKQHDLGELADVFLILEYRVREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Q4</accession>
    <name>A0A1W1I8Q4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">46 kDa membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ag</name>
        <name evidence="11" type="ORF">NSJP_3006</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3006"/>
    <dbReference type="EnsemblBacteria" id="SLM49173">
        <property type="protein sequence ID" value="SLM49173"/>
        <property type="gene ID" value="NSJP_3006"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3006"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="10">
        <location>
            <begin position="15"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM49173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="445" mass="48560" checksum="0D2B136011ED2351" modified="2017-06-07" version="1">MSDVSLSLLIFGLTYLLIITERIHKTIIALFGAALMIALGIVTQEEAFYSHEFGVDYNVIFLLIGMMVIVNIVRETGLFEVLAIWTAQRSDAQPFRMLLLLAVITALLSATLDNVTTVLLMAPVTLSITKRLDLNPVTFLLVEAMASNIGGTATLVGDPPNMMIASKAGFGYLDFLVRLGPIAVVILTVFLGSLWWLAGRSMRVDSSLRDTVLTLRIEDAVQDRGMLRRCVWLLIIVNTAFCAHGWLRLEPATIALLGASLFMLFGHRRGSSGTAEELSYLTEVEWKTIFFFIGLFILIGALVKVGVIRRAAELLVAYTSDNPAGTTIAILWGSALLSAVVDNIPYVAAMNPLIVDLARSRHPSLIDQPALLHQPDILPLWWALALGACLGGNATIIGASANVIIVDLARKAGYGISFWQFARIGVPVTIGSMLLSSLYLWWLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8V2</accession>
    <name>A0A1W1I8V2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3056"/>
    <dbReference type="EnsemblBacteria" id="SLM49223">
        <property type="protein sequence ID" value="SLM49223"/>
        <property type="gene ID" value="NSJP_3056"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3056"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020080">
        <property type="entry name" value="OM_adhesin/peptidase_omptin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69917">
        <property type="entry name" value="SSF69917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012348148" evidence="1">
        <location>
            <begin position="28"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="329" mass="35982" checksum="97997598B5DED246" modified="2017-06-07" version="1">MKLSFPAGRMVLATALTCVSLISPVLAQEPEDEARRPPTEITIGTWISVGETKWAHNASSVPGLGNPTSKLDYKDVGTNVIDVAGKFWFSPKVFTKLNVGFANIGGGRLTDDDYGAGQQLFSSTQSNINGNNMWYVNADLGGRVTEFAHHRGYFDVFGGYQYWHTEYEAVGVAQISCNPAAIPGLTCLPPGTSTNQGQTVITNTTSWHSLRIGATSEYRITRRISIHGTAVFIPASYLDNKDQHHLRPDLQQNPSFAMTGYGIGADADVGLRFQFMKNFAAEVGYRVFWNQLISGNLTVYPVNDSSQSFPLTQFQSLRHGLTAGLTLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I934</accession>
    <name>A0A1W1I934_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3274"/>
    <dbReference type="EnsemblBacteria" id="SLM49441">
        <property type="protein sequence ID" value="SLM49441"/>
        <property type="gene ID" value="NSJP_3274"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3274"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="181" mass="20792" checksum="1AC8D7B8687C60CD" modified="2017-06-07" version="1">MANREEKVDARSLFLAAPGRSPEITESADAYGWLVGSWELDIRVYWATDVSAKGLKGEAHFGWALEGRAIQDVWIMPRVAERTSNQDKHMNMYGTTLRVWDASIQAWRITWINPAGDHREEQIGRWSGKDFVQLGVRSDGTPTRWMFTNIMPNSFRWTGEALKPDGTTWTLEGDFRVTRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I972</accession>
    <name>A0A1W1I972_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ppiB</name>
        <name evidence="8" type="ORF">NSJP_3373</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49540">
        <property type="protein sequence ID" value="SLM49540"/>
        <property type="gene ID" value="NSJP_3373"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3373"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="170" mass="18357" checksum="280A1272EA0F7347" modified="2017-06-07" version="1">MSEATDKTKATIAVTSKGQPMGEIVLRFFHSVAPGHVKNFVDLAQKGFYNGTAFHRVIPGFMIQGGDPNSKSADRASHGTGGPGYRIKAEFNSTPHKRGILSMARANDPDSAGSQFFICVADANFLDWQYTAFGEVVSGMDVADKVVSVKRDGRDNPLERIEMTVTISEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I997</accession>
    <name>A0A1W1I997_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Formate hydrogenlyase, membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hyfB</name>
        <name evidence="9" type="ORF">NSJP_3395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3395"/>
    <dbReference type="EnsemblBacteria" id="SLM49562">
        <property type="protein sequence ID" value="SLM49562"/>
        <property type="gene ID" value="NSJP_3395"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3395"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:ATP synthesis coupled electron transport"/>
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        <property type="project" value="InterPro"/>
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        </location>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="421"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
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        <source>
            <dbReference type="RuleBase" id="RU000320"/>
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            <dbReference type="Pfam" id="PF00361"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SLM49562.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="675" mass="72539" checksum="52C46A8A0BDDE79A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I999</accession>
    <name>A0A1W1I999_9BACT</name>
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        <submittedName>
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        <name evidence="2" type="ORF">NSJP_3344</name>
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        <lineage>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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    </dbReference>
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            <begin position="15"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF18599"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="SLM49511.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="241" mass="26765" checksum="A656E7F692D94800" modified="2017-06-07" version="1">MSWKSSLAREFPGAVSQDRFVAGSHEALHCHGFRAENTIAFASVCRDEVALSLVEAIEKTWGEVFTFSSLGGMLTLGKTGFSAAQQHAPIEHGRERYAYYALPHIAIDAQGEFGNYYRPGRQKVSHACGALVAFHHELANGALELALDPDDLEQSILKQHLLRKLKYGEVPNLLSLTRIAHAVIVEELERMIRLTVDPMRSDYGLFTGIQIHAPEGRHFVWPGTAYAVLNGTQFNLPTMKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9A5</accession>
    <name>A0A1W1I9A5_9BACT</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3440</name>
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        <name type="scientific">Nitrospira japonica</name>
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        <lineage>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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    </dbReference>
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            <dbReference type="Pfam" id="PF00248"/>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
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    </evidence>
    <sequence length="1247" mass="138996" checksum="7AFCB5F7D6E5F613" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9E9</accession>
    <name>A0A1W1I9E9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Ribosomal RNA small subunit methyltransferase D</fullName>
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        </submittedName>
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    <gene>
        <name evidence="3" type="ORF">NSJP_3384</name>
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        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3384"/>
    <dbReference type="EnsemblBacteria" id="SLM49551">
        <property type="protein sequence ID" value="SLM49551"/>
        <property type="gene ID" value="NSJP_3384"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3384"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="190" mass="20458" checksum="CC58E3563CC2FB7C" modified="2017-06-07" version="1">MRIIAGSHRGRHLCGPQGTTLRPTSDKVREALFSILGARVSGRRFLDLYAGTGAVGIEAISRGATAVTFVECDSRALQVLRKNLAACGFEDHAQVRVGRTENFLARPDWWDGPYGVVFADPPYADTQAIETVRIVWATELLAEDGVMVIEQDARAVLPPSVAGAALIRRYLYGDTALFLYGAAPRPGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9I7</accession>
    <name>A0A1W1I9I7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
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            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49463">
        <property type="protein sequence ID" value="SLM49463"/>
        <property type="gene ID" value="NSJP_3296"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3296"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="317" mass="34286" checksum="3B920F85722FD9D9" modified="2017-06-07" version="1">MSYRYNSVDIIVGVGMCAILFGALLLFAAANGTYQVAVPEPAITQEPVESLSGLNWLQPVIGQALVDGAIFERRTNQLLDQSTAELNRATIAANDFTSTAEDPFGSVMHQAEMMPVAHQARVQGIMGRAIVNDTKRGIRSGVLSADLYLSDYNTRMIRTIETRGQQLDEEFASTWQAVLGRSIVDAFQRYTDRAGAIQEQMGSALVHLTQGQWMAEEGGTALASQMGSLVLAAVRTEALEERLTLLAAIESSPEEPALPTTEPASWPDIPVGFVAAAGVLLMAVFFGGITLSAQRRDRIAMAEIQHQASKWVYRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9K1</accession>
    <name>A0A1W1I9K1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3561"/>
    <dbReference type="EnsemblBacteria" id="SLM49728">
        <property type="protein sequence ID" value="SLM49728"/>
        <property type="gene ID" value="NSJP_3561"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3561"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004509">
        <property type="entry name" value="Competence_ComEA_HhH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00426">
        <property type="entry name" value="TIGR00426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="152" mass="16373" checksum="50F40EE9B4CD7365" modified="2017-06-07" version="1">MIVSFLIKCAMVALTMGVIFWIGWTLPQPEPDGVRVLPDEAAPALHVEGPVGAAPIPVPITEGAEPVKRTSPTKGVGKIDLNRATEKDLESLPGIGAVLAGRIMKYRQDVGPFSRVEDLRDVKGIGKKKFDRIKNLIQVTIWPPDGDGRVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9X1</accession>
    <name>A0A1W1I9X1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 2-octaprenyl-3-methyl-6-methoxy-1, 4-benzoquinol hydroxylase</fullName>
            <ecNumber evidence="2">1.14.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.14.13.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3544"/>
    <dbReference type="EnsemblBacteria" id="SLM49711">
        <property type="protein sequence ID" value="SLM49711"/>
        <property type="gene ID" value="NSJP_3544"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3544"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="7"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="422" mass="45989" checksum="470F146ED8C40E1F" modified="2017-06-07" version="1">MNKGMIETDVAIVGAGGGGAVLALALAKQNIRTVVVDQAGSPSKSLRGEIIQPNGQAVLDRLGVLSSLPADATLSVRLFHFCRAGGTRLCSIDYGDLPPPYNRAIVTLANVAHHAIIAAIQQQKSVALHYGTSFTGLIREDERVVGISAEGRDGPLTIRAKVVVGADGAFSKVREALKIPVDLHLYGDGYLIAILESDDQIADTSYYVGNKTILGLFPVTGKKAYILYMIPKDSMEAVKQRGIPALQQTWSQIAPQFSRLFRNLNEWSQVGYLPTCRVRTPRWVANGAVLIGDAAHAMNPHASQGRMQAMVDAMTLADLIPSCLADKDYSAARLSAFERARRPQVNMLQRLADQQVFYWNTGNPVVARLRDRVFQTLDRNARLRYQVLSTTAGLRTVSPFSGIDRLIAAGLFPDIRSHERSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Z6</accession>
    <name>A0A1W1I9Z6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppnK</name>
        <name evidence="5" type="synonym">nadK</name>
        <name evidence="6" type="ORF">NSJP_3426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3426"/>
    <dbReference type="EnsemblBacteria" id="SLM49593">
        <property type="protein sequence ID" value="SLM49593"/>
        <property type="gene ID" value="NSJP_3426"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3426"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="69"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="143"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="184"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="286" mass="30954" checksum="F0CCBCF52E8124EB" modified="2017-06-07" version="1">MKSKSIGILTKPKFPEVKTTLQAVVSWLRARNIDVILDTTSAALLEEKGGLQKTQLAQKADVLLILGGDGTMLNAARLAGERGIPILGVNMGGLGFLTEVRLEHLYPSLERVFANDFVLDERLMLKTHVHRHGETVAQGIVLNDVVVSKGTLARMIELRISIHGQFVTNLRGDGLIISTPTGSTAYSLSAGGPILEPAVHSLILTPICPHTLTHRPLIVPDNVEIDVTLTSKDEGAMATLDGQVGIALTQGDTVALSVSELRTRLIRFPESTYYDVLREKLKWGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA13</accession>
    <name>A0A1W1IA13_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DGPFAETKE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49840">
        <property type="protein sequence ID" value="SLM49840"/>
        <property type="gene ID" value="NSJP_3673"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3673"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="130" mass="14773" checksum="DB4FB52A9E1C0FAD" modified="2017-06-07" version="1">MKYVCFGYLDAEQWGRLSPEEQQAMIDRCFTYDETLKRNGNWVYGDGLQGPDSTVSLQYQKGKVAVTDGPYAETKEILGGLLIIEALDSNHAVQLISNHPGLRMGRWEIRPALDLTPMIQESERRRGIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA59</accession>
    <name>A0A1W1IA59_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Rieske-type ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_3602</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3602"/>
    <dbReference type="EnsemblBacteria" id="SLM49769">
        <property type="protein sequence ID" value="SLM49769"/>
        <property type="gene ID" value="NSJP_3602"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3602"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="110" mass="11545" checksum="3D13E577BF5843A3" modified="2017-06-07" version="1">MSDFVTVATVDQIPPGSGRTVEVHGVRIALFNVDGTFYAVDNTCPHAGGPLGEGFVCGDAVECPWHGWKFNLRTGERCGSPNITVACCLVQVADGTIQVALPPDFNPQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA72</accession>
    <name>A0A1W1IA72_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49811">
        <property type="protein sequence ID" value="SLM49811"/>
        <property type="gene ID" value="NSJP_3644"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3644"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="84" mass="9077" checksum="D206D1B72B0D0EC0" modified="2017-06-07" version="1">MVGHRASEIRSALGLFVVVGLCLYCIPSYADTQRGIAAFDRKDYPTAFREFMESAKKGDAEAQAGVGAMHVEKINPPGTGKPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA99</accession>
    <name>A0A1W1IA99_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3674"/>
    <dbReference type="EnsemblBacteria" id="SLM49841">
        <property type="protein sequence ID" value="SLM49841"/>
        <property type="gene ID" value="NSJP_3674"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3674"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="139" mass="15698" checksum="21EC0FCAE8F7D2CF" modified="2017-06-07" version="1">MDQWISKDTLHWIYAGSGLLLLVIAIAVPWVLITMPRDSFSHPNRHNWLDRKPAAIRVPLRILKNVLALTLIVVGIAMFLTPGPGIFPILLGIFLADFPGKTTLQSRVVRKPTVMNSLNWLRRTFHRPPLQLPPKKLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAC2</accession>
    <name>A0A1W1IAC2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49997">
        <property type="protein sequence ID" value="SLM49997"/>
        <property type="gene ID" value="NSJP_3830"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3830"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="240" mass="26038" checksum="037A8666AC984A07" modified="2017-06-07" version="1">MRRGIGIVLGFAVITGCTGVTPTPAERNVQDVAATRAWLRGPMKESCDRLPGPESRKGCALALDGTLAKLRGDHLTRDDNFRIELARAKGADELRRLWTRPDHEAWLRGIRTAACQRAPYPESARRCLDGIEAELLRLSHPDEVASEQPEVRAKRAVARIEAREQARAAEQQRPREREFSLVGLAGESGQAQPSVSLSVSKHPVVVKPVQPGLGMPVAPLSPPVSCTSTVVGGAVRTDCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAJ3</accession>
    <name>A0A1W1IAJ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50012">
        <property type="protein sequence ID" value="SLM50012"/>
        <property type="gene ID" value="NSJP_3845"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3845"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012754596" evidence="1">
        <location>
            <begin position="25"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="172" mass="18378" checksum="49FB9562639F1D29" modified="2017-06-07" version="1">MPSMLAQMRISLVVALCTLPHAQAAWSQVIGEAAELDRLRARAEEAIGNDDPDGAALSMGRAALMAKQLSKSHRDDPAAAKLYQGAEPLFRAQEHGYRAIALFRRAGGQLPASSGVCGSLALAQGSLQQALVLLVPDEQAPADVRERTKKLREAADDWVTVVASMISDYQCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAS7</accession>
    <name>A0A1W1IAS7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49999">
        <property type="protein sequence ID" value="SLM49999"/>
        <property type="gene ID" value="NSJP_3832"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3832"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="113" mass="13156" checksum="610A19D4C3230F49" modified="2017-06-07" version="1">MLGTDIRGIMAEEEEVQRRRQALKSLLSMRSKQLRESLDQRIKRARTGGDWIQLSKEECATLHRQEKAHLKSQLEQLQHEDDRTRGKLTALKRAKARAQRIRAAEAASGRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB68</accession>
    <name>A0A1W1IB68_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichyl-phosphate mannose synthase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50264">
        <property type="protein sequence ID" value="SLM50264"/>
        <property type="gene ID" value="NSJP_4097"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4097"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="264" mass="30059" checksum="615C19B4910BDC17" modified="2017-06-07" version="1">MLTKGIADTRVMKLSIIIPAFNEAETIEAVVERIRAVDLGNISKEIVVVDDASDDDMPRILDRLTGIQVIRHSVNSGKGAALSTGIRAATGEVVIFQDADLEYAPEDYPAVIEPILNGVCDVVMGSRFLRERPVFWGQHKSPYLNHYIGNLLIQHVTNILYGRRFTDYEGCYKAFLRSHLLDTPIEATGFEFDNELICKLLRKHMRIREVPIRYNPRTYSQGKKITWRHGLIILWTIVKWRFHPLEVTGPAPIGTRRYRSDPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB99</accession>
    <name>A0A1W1IB99_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_4160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4160"/>
    <dbReference type="EnsemblBacteria" id="SLM50327">
        <property type="protein sequence ID" value="SLM50327"/>
        <property type="gene ID" value="NSJP_4160"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4160"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="378" mass="42903" checksum="BB0439D32F62B815" modified="2017-06-07" version="1">MRYEFGKNWSEFARRHVTDERITTACRCLLDFLKLDDLRGKTFLDIGCGSGIHSLAAYRAGASRIIGFDYDPDSVRTSQMVREQAGSPDNWEILQGSVLDRSFLDKLDRADVVYSWGVLHHTGSMWEAVANASSLMKPDSVFCIALYTTDIFIDPTPEYWLSLKQRYNRAGAMARRYMEWRYALRATILPELRAGRNPLAYIREYGRSRGMSYWTDVKDWLGGWPMEFAGIAETKAFCTNQLGLELLNITAGEANSEYLFRKKGSTNYWDGIAGRRTEMALDTPFVHRGGQAWIAYVPQYLPEADTVEEPRRSRLMLCEDGLPLGFAHAPHSQIEAYGGSRYSHWGDSLIFSTTDRSDPNTNGRRYSIYLDAGSGSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBB6</accession>
    <name>A0A1W1IBB6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Cell wall biosynthesis glycosyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50189">
        <property type="protein sequence ID" value="SLM50189"/>
        <property type="gene ID" value="NSJP_4022"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4022"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="418" mass="45853" checksum="16CF48ECA6DC31E9" modified="2017-06-07" version="1">MVLLARRMPTKAHSLVPSMNTVLAILLILILIPLSALLLYQWFLAVASFFFRSPAASARTAKSHFVILIPAHDEEVGIGSSLESIGRLNYSSTHYHVVVVADRCTDDTATIARKMGAQCFERSDGQSGKGAALAWGIQQARNANIPFDAVVIVDADTVVDRNLLSAFDEKLESGHEVQQGYNYLSNPWSTPFTRIIAVTSTLRNGRYYTGKTVLGIPGMLTGTGMCISAEVLNRHGWTAFSVGEDWEFSVQLLLAGDSIYFNPAARAFARESQGLKQASRQRLRWASGRYAIMGEKLWALISTGVRNRSYSLVDEAVTLLAPNYSSQASLALLCLVGSWLVASDPLWTFVWYWSIGAFITIAGYFVLGVLSTEAPGKALAGLALVPIFLPWRMTIELLGMMGYGRRHWGRMSRGKVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBJ3</accession>
    <name>A0A1W1IBJ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4092"/>
    <dbReference type="EnsemblBacteria" id="SLM50259">
        <property type="protein sequence ID" value="SLM50259"/>
        <property type="gene ID" value="NSJP_4092"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4092"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007462">
        <property type="entry name" value="COV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31876">
        <property type="entry name" value="PTHR31876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04367">
        <property type="entry name" value="DUF502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="222" mass="24183" checksum="B55301518C34474F" modified="2017-06-07" version="1">MLKASLKRYFLTGLLVITPIWGTVLILKTLFVAVDGILGNLLAEMVPNHYVPGLGILALIVLVFATGLFAANFMGKQIVKVWEGWLNRVPLVRGIYSTLKSMMDILSFSERGSYHRVVLIQFPKNGHYCFAFVTGVTKGEMQEITQDALVHVYVPTSPNPTSGYFLLVPEREVTSVDISVEEAMKLIISGGLYSPTPSLAATASAEAKWGSIKQPDPGVPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBT8</accession>
    <name>A0A1W1IBT8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Undecaprenyl-phosphate galactose phosphotransferase RfbP</fullName>
            <ecNumber evidence="9">2.7.8.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_4066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.6" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4066"/>
    <dbReference type="EnsemblBacteria" id="SLM50233">
        <property type="protein sequence ID" value="SLM50233"/>
        <property type="gene ID" value="NSJP_4066"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4066"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047360">
        <property type="term" value="F:undecaprenyl-phosphate galactose phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017464">
        <property type="entry name" value="Sugar_tfrase_EpsB_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03013">
        <property type="entry name" value="EpsB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="169"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM50233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="357" mass="40683" checksum="2A4F4F49BF126B23" modified="2017-06-07" version="1">MSLIVSSSDRSGSQRVRPFVDERAPKAIFRVPGAKRRILILGTGPLARDLSQILLSRRRMFTDVVGMLAKDDAQMLEGSREQTVIGVMDQLVDVVERHRVDTIAVCLEDRRAILPLKELLDLKGMGIDVFDGHHLYEEESGRIPIDELKPSAIIFSTGFRAGFIVKTLKRFIDVCLSFVGLAALLPVMVLVGIIIRLDSPGPVFYRQVRVGLRAQPYMIWKFRSMFIDAEKGGARWTTEKDPRVSRVGRYLRKWRLDEIPQLINVLKGEMSLVGPRPERPVFVQELRSVIPYYDIRHAVRPGITGWAQTQFRYGASVEDSHVKLQYDLYYVKHLSLRLDFRILIETVRVISLGEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZN0</accession>
    <name>A0A1W1HZN0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proteasome subunit alpha</fullName>
            <ecNumber evidence="2">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">prcA</name>
        <name evidence="2" type="ORF">NSJP_0044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.25.1" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0044"/>
    <dbReference type="EnsemblBacteria" id="SLM46216">
        <property type="protein sequence ID" value="SLM46216"/>
        <property type="gene ID" value="NSJP_0044"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0044"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022296">
        <property type="entry name" value="Proteasome_asu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF69">
        <property type="entry name" value="PTHR11599:SF69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03691">
        <property type="entry name" value="20S_bact_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="227" mass="25026" checksum="CFCB7EDF0B00F1D9" modified="2017-06-07" version="1">MAMPYYVSPEQMMQDKAEYARKGIARGRSIIAMEYVNGILLAADNPSASLHKISEVYDNIAFAGAGKYSEFENLRKAGIRHADLKGFMYSREDVTARSLANGYSQSLGTIFGQELKPLEVEILVVQVGNNGHANEMYRISFDGSIIDERLYAVIGGKSEAVQALLKDKLPAEPPDLKAALSLCVSSLDPTGSQKLSPESLEVAVLDRTRDSRKFRRFTPTETKQLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZU6</accession>
    <name>A0A1W1HZU6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 18" type="primary">uvrB</name>
        <name evidence="18" type="ORF">NSJP_0065</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0065"/>
    <dbReference type="EnsemblBacteria" id="SLM46237">
        <property type="protein sequence ID" value="SLM46237"/>
        <property type="gene ID" value="NSJP_0065"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0065"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="25"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="430"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="15">
        <location>
            <begin position="624"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SLM46237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="667" mass="75637" checksum="22916223D9BB929E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I019</accession>
    <name>A0A1W1I019_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46341">
        <property type="protein sequence ID" value="SLM46341"/>
        <property type="gene ID" value="NSJP_0169"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0169"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="280" mass="30956" checksum="2EA058BD6DBEECCF" modified="2017-06-07" version="1">MLYFREEKAPNGRMTEGQVSRKGARGVSFALVSAMLLASCASAVPPSRLGDYLSPESQADAGVFGRLEPRPVPAGLLLVSDTAHPGASPNLPDEALRQLGESLKQEVSRAIPVRIKEMVPPESIQPQANGDWAQFAELAKKHELEYLVLVVLSSTEQEYPVTLFLGWTTYAQPGFRRDNWSLLEVALLDVRNNRVLIQAEGRGWATLDSPTAPGINQWYPVIYLRPQDPERRIWPPTYEGAPNTLRVVSFDQAAKRMTLNLQKAWIESLQAAGAEVHESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I039</accession>
    <name>A0A1W1I039_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Extracellular ligand-binding receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0189"/>
    <dbReference type="EnsemblBacteria" id="SLM46361">
        <property type="protein sequence ID" value="SLM46361"/>
        <property type="gene ID" value="NSJP_0189"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0189"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="308"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="677" mass="74187" checksum="C2D22C1DEF476205" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I086</accession>
    <name>A0A1W1I086_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0234"/>
    <dbReference type="EnsemblBacteria" id="SLM46406">
        <property type="protein sequence ID" value="SLM46406"/>
        <property type="gene ID" value="NSJP_0234"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0234"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="254"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="455" mass="51296" checksum="C24162C09F06381B" modified="2017-06-07" version="1">MKILQISTYDKGGGAEAVAWELFSAYRRRGHLSRMAVGDKRTGDSDVTTFPLDERRWPVRLSRRLAPYEGRIRGAWRLRRWLELYAAYPPAWVQSRLGRENFNFPETWRLFQQMENQPDVVHCHNLHGGWLTRGGYFDLRMLPWLSRRVPTMLTLHDTWLLSGHCAYTLGCDRWKTGCGRCPDLSIYPALARDGTAHNWRMKQSIYDDSRLYIATPSRWLMRQVEQSMLAPAVIEGRVIPNGVDSAVFCPGRKDEARASLGLPQDAAILLFVANAAKQNIFKDYKTVEACAIRVAARFRTRKVLLLVLGEADETHVFDNGEIRCVPFQTQRAVTARFYQAADVYVHAAKSDTFPNTILEALSCGIPVVATAVDGIPEQVEEGRSGFLVPAGDADSMAAHVYRLLSTESLRAAIGRAAAERASRLFGLDRQVDAYLGWYGEMAARNQTKKELAHAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0C9</accession>
    <name>A0A1W1I0C9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46458">
        <property type="protein sequence ID" value="SLM46458"/>
        <property type="gene ID" value="NSJP_0286"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0286"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="111" mass="13138" checksum="4AD0B6BA5CF86B4E" modified="2017-06-07" version="1">MIRHDWLRTFCTGFTDPLQRERERIRTEMAGIWGLLGLLMKQRNGAWWATEERRRLGLELRRVVALCPYLLALLAPGSFVLLPVVAWWLDRRRQSRCVNHVQPARPLTMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0E5</accession>
    <name>A0A1W1I0E5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46461">
        <property type="protein sequence ID" value="SLM46461"/>
        <property type="gene ID" value="NSJP_0289"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0289"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="37" mass="3921" checksum="025DF386E3A27D8D" modified="2017-06-07" version="1">MDALMAADMPMGGTNAQRIDRLLSIASPVDVSQFLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0K2</accession>
    <name>A0A1W1I0K2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family group 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0340"/>
    <dbReference type="EnsemblBacteria" id="SLM46512">
        <property type="protein sequence ID" value="SLM46512"/>
        <property type="gene ID" value="NSJP_0340"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0340"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="337"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="744" mass="82637" checksum="87121FA27C7228EF" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0M3</accession>
    <name>A0A1W1I0M3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0378"/>
    <dbReference type="EnsemblBacteria" id="SLM46550">
        <property type="protein sequence ID" value="SLM46550"/>
        <property type="gene ID" value="NSJP_0378"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0378"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="321" mass="34579" checksum="8A5BAEB03BE7914C" modified="2017-06-07" version="1">MRFSQPLAVALSQALIATGCSFIIPSTQTTTPERYCGPVRPMNVEIAHAPASVDPTAIPLSERSLQLAAVMNVLPLLSKMAVLDHAGESHGLAFLELRQMLTDRLLLTLFEVSSTTAEIVCERDRADQVADRMDEIDSARVKKLTLVSIVVAGVASIVSGAIGLAGAATTASDASTVASGVLASLFGGMALFTATKQEFSHERNLLKEVWDNPTRSTIFSPAVWRFLQRPHHADRSATARDDVINAWRQQGRLGEPGSPGEDDRMALIFGAGGTYASADLRARASMLETLEAHVQLFSEELEQFLGEFIHVRHEAMKGAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0P2</accession>
    <name>A0A1W1I0P2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46423">
        <property type="protein sequence ID" value="SLM46423"/>
        <property type="gene ID" value="NSJP_0250"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0250"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="78"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="253" mass="29067" checksum="2D2C090ACD489EF3" modified="2017-06-07" version="1">MKTETVSAYALPSPHVISKRAAILQSDGSMNRSLRREFVDEFFSRHVAVISKGSTVLDLGGHRPPRRGRFDIDRYGLSVRSANISVSRRPDVQTDASRLPFLTESFDAIICSELLEHVPEPLPVLREVHRTLRPHGVLLMSVPFLFHIHADPHDYGRYTDQYWKENLDRIGFRDVVIEKQGLFWSVIVDMMRGWLCECRRTGRLHSALSDRVATMVIRRAKKWALEREQLIPVASEQYVSRYTTGFGIRAVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0P8</accession>
    <name>A0A1W1I0P8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="5">4.1.2.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Queuosine biosynthesis protein QueD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pts</name>
        <name evidence="11" type="ORF">NSJP_0406</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.50" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0406"/>
    <dbReference type="EnsemblBacteria" id="SLM46578">
        <property type="protein sequence ID" value="SLM46578"/>
        <property type="gene ID" value="NSJP_0406"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0406"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003874">
        <property type="term" value="F:6-pyruvoyltetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022470">
        <property type="entry name" value="PTPS_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00987">
        <property type="entry name" value="PTPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM46578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="136" mass="15392" checksum="F5101FF04CB9F8CD" modified="2017-06-07" version="1">MQFTMTRRYRFCAAHRLHTDHLTPEENRTAFGKCNNPNGHGHNYVVLVTVRSGANEGAVALERLDRIVEETIVERFDHQDLNQDSEFAALTTTGENLVKLIWNLLAPKLPAGILEKVGVIETRDNYFEYAAPTGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0S3</accession>
    <name>A0A1W1I0S3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0410"/>
    <dbReference type="EnsemblBacteria" id="SLM46582">
        <property type="protein sequence ID" value="SLM46582"/>
        <property type="gene ID" value="NSJP_0410"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0410"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010389">
        <property type="entry name" value="Urate_ox_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06181">
        <property type="entry name" value="Urate_ox_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Urate_ox_N" evidence="2">
        <location>
            <begin position="36"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Urate_ox_N" evidence="2">
        <location>
            <begin position="115"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="195" mass="20859" checksum="43241C5E4E085B00" modified="2017-06-07" version="1">MKFLEDPMQTIGAGFALSVVLIIVYLGLSGVGAGDADWAGILLRWIHFLAGITWIGLLYFFNLINAAFMKSLDGPTKNVVIPKLMPSALNWFRHGATVTVLAGILLYGKLYMHGGTGAYALAIGGLLGIIMMVNVHAVIWPNQKKIIAAVTAAAQGTPAPAEMAQWGRTALLASRVNFLLSIPMLFFMGAGSHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0S8</accession>
    <name>A0A1W1I0S8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Response regulator, CheY-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0436"/>
    <dbReference type="EnsemblBacteria" id="SLM46608">
        <property type="protein sequence ID" value="SLM46608"/>
        <property type="gene ID" value="NSJP_0436"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0436"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="19"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="145" mass="16078" checksum="436046A77EAE851B" modified="2017-06-07" version="1">MGAEFTSGFFMPDHATNGRVLVVDDEADIRKVVRMTLQKAGYDVLEAENGEKAIETINAGENRLLLDVVICDIRMPKINGVEAIAYFRSNYPRVPLIVLTGFPDTDMATSLLRQGVVDYLVKPVEGEKLREAVARAMGQRELAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0T1</accession>
    <name>A0A1W1I0T1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46479">
        <property type="protein sequence ID" value="SLM46479"/>
        <property type="gene ID" value="NSJP_0307"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0307"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="187" mass="20419" checksum="BA22670D0527BA27" modified="2017-06-07" version="1">MTERPSTHRSGFILLGLVLLSSPGCLHNIHVTPLPQTEAQTTIPASAQVVVPFLALEGADHMPGIGSLDWPVKDFHAAAIDYFAKRRTFLSVGDEPAALTLTIKAWLTMRSRSSYVYKLRLESDLGPAGEPPTSSYLSEKTAIGSSVRWVTASDRDPIQRAVQEALDDLAQQIEADARLHESKKSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0U9</accession>
    <name>A0A1W1I0U9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_0327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CpxP/Spy family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0327"/>
    <dbReference type="EnsemblBacteria" id="SLM46499">
        <property type="protein sequence ID" value="SLM46499"/>
        <property type="gene ID" value="NSJP_0327"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0327"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012899">
        <property type="entry name" value="LTXXQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07813">
        <property type="entry name" value="LTXXQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012099595" evidence="6">
        <location>
            <begin position="26"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="199" mass="21505" checksum="F1635675BCD95344" modified="2017-06-07" version="1">MRPRTSLMLGLVLGSSLIGLPAAWADGGGRCAGKSHQMSFHQDGHRHGGFTSHLLKHLLKNKQELGLTDDQVAKMRTIALDADKARIRAEADVMVSERELRSMMWDDKAQLPAIEAKIKEGEAYQATVRIIGVRAARELIGTLTPEQQAKQKTLWEQSRHHRHQGAGADQYPGRTSGIESGTGPSAAGESEPVDGPSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Y6</accession>
    <name>A0A1W1I0Y6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATP synthase F0, subunit I</fullName>
            <ecNumber evidence="2">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.14" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0494"/>
    <dbReference type="EnsemblBacteria" id="SLM46666">
        <property type="protein sequence ID" value="SLM46666"/>
        <property type="gene ID" value="NSJP_0494"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0494"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032820">
        <property type="entry name" value="ATPase_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09527">
        <property type="entry name" value="ATPase_gene1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="73" mass="7792" checksum="02EDCBC99473A04C" modified="2017-06-07" version="1">MPPSQDPFYAGLGQAVRMGTELLAALIVGGGLGWAADTYLWETNPWGMVSGLVLGVIAGIRNAYRSAQRWPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0Z0</accession>
    <name>A0A1W1I0Z0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46513">
        <property type="protein sequence ID" value="SLM46513"/>
        <property type="gene ID" value="NSJP_0341"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0341"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012596661" evidence="3">
        <location>
            <begin position="28"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="347"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="401" mass="44156" checksum="0F980F8FA3F4EB19" modified="2017-06-07" version="1">MTSMSSIQWVCTAACACILLSFSPSHAPAAQPAAGAAPSPKTVLVKKYLDDCRAQSSKEASCDKLRKDAIDILTDDLHTLGSSADRVYFLSILPVFKSDAPELRIAAADAIGMIGPQDGDVDVLAPLANDPVPDVRQAVSQMIGRGKGTALSLLKQRLISMRTGRVPDRPADPTKLGLPVAPNSLYLFDWSDESLGRLSYLAKNMNEAASFFKGKAKKGPFPLEEFKDKYRFQFQDEEEAMRSAQEAEAKQMEQSKPPDPTNVQAYTEFMQKIASVGARQGGRLLLDSYQPNLFGSPTVYVLEERQIGQRSYPTRYVVLYQEQALRKPGYRFSWMTATDDAIKTAQVASLAEEKQELANKAENEAQKKKAAELEALTKKKDAAEKKQFKKGQDDLEKALGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I105</accession>
    <name>A0A1W1I105_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anthranilate synthase component 1</fullName>
            <ecNumber evidence="3">4.1.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">trpE</name>
        <name evidence="3" type="ORF">NSJP_0495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.3.27" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0495"/>
    <dbReference type="EnsemblBacteria" id="SLM46667">
        <property type="protein sequence ID" value="SLM46667"/>
        <property type="gene ID" value="NSJP_0495"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0495"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="2">
        <location>
            <begin position="31"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="216"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="495" mass="54561" checksum="BDA6742244947990" modified="2017-06-07" version="1">MIRLSLPSKSAFLNGPPQPLVLTLASPQPVRPVDLYARLASISGPSFLLDSGSPQHGSGRFSYIGSSPVTVFSSRQTGGCAPEPDPFHVLRKEIAVGPIARTPHLPPFFGGAVGYLSYDFARRLEHLPATAPVDLSLPDLQFALFDVVTAVDHDQNRIHIMFCPSATRFLGEDRAKLLQEGLDKIAGCEASYAASQTDPPSDSAIPSVSFVPEQSREAYLDRVGRCQRYISDGDIYQANLSHRFTFRIPGCRTRAERLRYEQALYRRLARVNPSPFSGLLRFDDVTLISASPERLVRVRDGWADTRPIAGTRPRGRDSEEDRRLVAELLATEKERAEHVMLVDLERNDLGRVCEFGSVRVDEFMAVEQYSHVSHIVSNVSGRLQPNVAPFDVIRAVFPGGTVTGVPKIRCMEIIDELEPVRRGPYTGSFGYIGWNGDVDLNIIIRTLVLSEHTGYLQVGAGIVADSDPALEYDETLHKAEAFFSALQRGHSCGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1G4</accession>
    <name>A0A1W1I1G4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46709">
        <property type="protein sequence ID" value="SLM46709"/>
        <property type="gene ID" value="NSJP_0537"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0537"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="320" mass="36563" checksum="F42F1231CAA5818D" modified="2017-06-07" version="1">MSDISKYLESVKERFALSSDYAVAKKLGIAQPEANLIRRGLKIPKPELCIKIAKLLDKNPVELLLIAQKDKAPSSAKEYWTLALTAVDVMLHVPKNPKYIPRKVEAIGRELRQLETQTLTYEGAEANAEAVRLVQTAEQSIDAVMERWNIWKKGEALYPNYLLANQEAAKRGVRIRRLLVLTREQMEQEPVVHDAIQVMDDQQRAGIDIFFAFREELERAPTFQRFEEDYRSQGAARDLNAAIFDGEILIFSQSYGQVQLGVVGPPTPITMINQLEITWKPDLLRDLDPAPLFDMTRYVFEYKDPRAFRGELARFKKAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1M7</accession>
    <name>A0A1W1I1M7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0744"/>
    <dbReference type="EnsemblBacteria" id="SLM46916">
        <property type="protein sequence ID" value="SLM46916"/>
        <property type="gene ID" value="NSJP_0744"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0744"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="114" mass="13474" checksum="22983B080052006D" modified="2017-06-07" version="1">MGNEPRLGSKVFYKIGEVSQVTKLPAYVLRFWESQFPFLNPKKSRGNQRLYVRRDIETVLEIKRMLYEEGHTLEGVKRYWARRGRISPQRVKPKELAQKLRGSLRAILKLLESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1P9</accession>
    <name>A0A1W1I1P9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integration host factor subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ihfA</name>
        <name evidence="9" type="ORF">NSJP_0745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0745"/>
    <dbReference type="EnsemblBacteria" id="SLM46917">
        <property type="protein sequence ID" value="SLM46917"/>
        <property type="gene ID" value="NSJP_0745"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0745"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13835">
        <property type="entry name" value="IHF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005684">
        <property type="entry name" value="IHF_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM46917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="91" mass="10120" checksum="58EBC2554FFA51CA" modified="2017-06-07" version="1">MRKADIANEIYKQVGISKNEAADIVELVLNMLKAVLQKGESVKIAGFGNFVVRSKGARKGRNPRTGEEIGITPRRVVTFRPSQVFKKYVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1S7</accession>
    <name>A0A1W1I1S7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46947">
        <property type="protein sequence ID" value="SLM46947"/>
        <property type="gene ID" value="NSJP_0775"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0775"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="116" mass="12975" checksum="CDBBB119F1DB2B95" modified="2017-06-07" version="1">MANRWAFPVLLSAVALLFEPHFPPIPSSAVASDVGTIIEQFVTQRFPEAATHYWIINETQWDGDEIIIDVHTIVQDRRDPEPTLNRFLLLIVAGELKGSQNIPLEPGAECRPEQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1S9</accession>
    <name>A0A1W1I1S9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46966">
        <property type="protein sequence ID" value="SLM46966"/>
        <property type="gene ID" value="NSJP_0794"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0794"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012167333" evidence="1">
        <location>
            <begin position="34"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="118" mass="13408" checksum="75462C8C490B1E83" modified="2017-06-07" version="1">MSIFARTQSRPWSFPALLLALLTVFLAPMPALAGSDDLRIEITKKGLGKEVVITQGTREWYMLVEVTPENTVVVRQEKEQDRYLVDESETHDRPLAPIEVDGAITDYINSVKTRVHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1T7</accession>
    <name>A0A1W1I1T7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0785"/>
    <dbReference type="EnsemblBacteria" id="SLM46957">
        <property type="protein sequence ID" value="SLM46957"/>
        <property type="gene ID" value="NSJP_0785"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0785"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="455" mass="48312" checksum="855ED0D9BE53A762" modified="2017-06-07" version="1">MAQTLERLLDALEDVDDATREEAAKALAELADPKGLEALISACSDEYWSVRAHAASGIAKIGGQKAVEALVELFDDPIMEVRNQAVESAARIGAAVLDRMLAGLKDQRWRVREHAAKTCGEIRDPRVVDALVVACRDRDGAVKSAAAEALGKIGDPKAVPVLIKLFRDTSKIVRETAGTALVYIGPPSVDPLISCFADKDFVVRCHAARALGGMTTDYQIGRTWVREPKVVDALVAALKDPDRAVREDATIALGMIGDARAIDALIEAMKDGAVKRHAIASLGMIGDPRALPPVLDALKGKGIRQDGTPTPGCIVSEDAFIKEAAATALGQFRDPRVIPDLIMLLKDGVLREKASAALAAIGDTAIEPLIAFLYDPKASEVASEGERVLSYASVRLSAKDALRQLVMETLEKLGWILPQEDSTVDSSNVDNARVDLPLGAGGRFGPSGDFAKGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1U6</accession>
    <name>A0A1W1I1U6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46962">
        <property type="protein sequence ID" value="SLM46962"/>
        <property type="gene ID" value="NSJP_0790"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0790"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011963832" evidence="1">
        <location>
            <begin position="31"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="137" mass="14530" checksum="2D3AEC362567DE46" modified="2017-06-07" version="1">MRSVKTVSRFIGSAITLTLLVTLTIPAAHAAPARVAKDGGERSKAVAMAARYLQGPGFADPMLAAETAPDASLSVEVDHKGWARMDREQRMDFLDRMNGGVLRANGGVSVDIHVSMNGSKVATSTFSSGQQVMRLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Y4</accession>
    <name>A0A1W1I1Y4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0819"/>
    <dbReference type="EnsemblBacteria" id="SLM46991">
        <property type="protein sequence ID" value="SLM46991"/>
        <property type="gene ID" value="NSJP_0819"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0819"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="193" mass="22660" checksum="543AE5FEBE3EB94E" modified="2017-06-07" version="1">MRLWIVTGLIAGIWVGQGQPAAALEFTADQFTKIDGRTHKSSIYYRDQMWRIEHHSMGPVNVSIVRKDKQVVWLLLSRMKHFKEVPYDPDQDLRVTEKLEGEISRQEIGTEVREGHPTVLYEVSTKHGERIENYYQWVATDIHFPMKLAKKDGSWIVEYQHVKLRSVSDYLFNLPLNFHPLEEFHKDLSNQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I278</accession>
    <name>A0A1W1I278_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Formimidoyltransferase-cyclodeaminase</fullName>
            <ecNumber evidence="6">2.1.2.5</ecNumber>
            <ecNumber evidence="7">4.3.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Formiminotransferase-cyclodeaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">NSJP_0797</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the formiminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.5" evidence="6"/>
    <dbReference type="EC" id="4.3.1.4" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0797"/>
    <dbReference type="EnsemblBacteria" id="SLM46969">
        <property type="protein sequence ID" value="SLM46969"/>
        <property type="gene ID" value="NSJP_0797"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0797"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030412">
        <property type="term" value="F:formimidoyltetrahydrofolate cyclodeaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030409">
        <property type="term" value="F:glutamate formimidoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007044">
        <property type="entry name" value="Cyclodeamin/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013802">
        <property type="entry name" value="Formiminotransferase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037070">
        <property type="entry name" value="Formiminotransferase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004227">
        <property type="entry name" value="Formiminotransferase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012886">
        <property type="entry name" value="Formiminotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037064">
        <property type="entry name" value="Formiminotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022384">
        <property type="entry name" value="FormiminoTrfase_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036178">
        <property type="entry name" value="Formintransfe-cycloase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02971">
        <property type="entry name" value="FTCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04961">
        <property type="entry name" value="FTCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07837">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01221">
        <property type="entry name" value="FTCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01222">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101262">
        <property type="entry name" value="SSF101262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55116">
        <property type="entry name" value="SSF55116"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02024">
        <property type="entry name" value="FtcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="15 23" id="KW-0456">Lyase</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 23" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FTCD_N" evidence="22">
        <location>
            <begin position="3"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="FTCD" evidence="21">
        <location>
            <begin position="182"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="511"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00017787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM01222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SLM46969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="557" mass="60408" checksum="36872272FE35F157" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2C1</accession>
    <name>A0A1W1I2C1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="12">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alpha-IPM isomerase</fullName>
            <shortName evidence="12">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">leuC</name>
        <name evidence="14" type="ORF">NSJP_0960</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="12"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0960"/>
    <dbReference type="EnsemblBacteria" id="SLM47132">
        <property type="protein sequence ID" value="SLM47132"/>
        <property type="gene ID" value="NSJP_0960"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0960"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 12" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="10 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="13">
        <location>
            <begin position="8"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM47132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="467" mass="50198" checksum="FF60DA59F6230691" modified="2017-06-07" version="1">MSSRTLFDKIWDSHVVRQEPDGTTLLYIDRQLVHEVTSPQAFEGLKLAGRRPRRPGATLAVPDHNVPTTDRRLGIADPISAKQIRTLEDNCRDFGITLFGMDDPRQGIVHVIGPEQGFTLPGTTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQCLVQKRPKTMEIRVDGELSPRCSAKDVILSIIGKIGTAGGTGYVVEYTGSTIRGLSMEGRMTLCNMSIEGGARAGLVAPDDKTFAYLKGRPLAPQGELFEQAVRVWRKLGSDPGARYDATVTLQADAIAPQVSWGTSPGMVTGVDGRVPDPRGLADDKARQAVERALEYMGLTANMPITEIKIDKVFIGSCTNSRIEDLRLAAGLAKGKRVARTVHAMVVPGSGLVKQQAEQEGLDKVFVEAGFEWREAGCSMCLAMNADVLQPGERCASTSNRNFEGRQGAGGRTHLVSPAMAVAAAVEGHFVDIRHWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2R8</accession>
    <name>A0A1W1I2R8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterioferritin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1128"/>
    <dbReference type="EnsemblBacteria" id="SLM47300">
        <property type="protein sequence ID" value="SLM47300"/>
        <property type="gene ID" value="NSJP_1128"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1128"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014490">
        <property type="entry name" value="Dps-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018063">
        <property type="entry name" value="Ferrtn_UCP018063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="31"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR018063-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="177" mass="19826" checksum="C7067229B17E1CC1" modified="2017-06-07" version="1">MKDGQFTLDIKSIRERARKHIGDGAVTAGYKAKAPVVLNLLNDALATEVVCVLRYKRHYFMAQGLRSESVKTEFLEHAKEEQAHADALAERIVQLGGEPNFSPDGLLSRSHSEYAEGHSLEDMISEDLVAERIAIDSYRQMIEYIGADDPTTRRLLEEITAKEEEHAEDLASLLNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2U2</accession>
    <name>A0A1W1I2U2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha,alpha-trehalose-phosphate synthase (UDP-forming)</fullName>
            <ecNumber evidence="4">2.4.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">otsA</name>
        <name evidence="4" type="ORF">NSJP_1119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1119"/>
    <dbReference type="EnsemblBacteria" id="SLM47291">
        <property type="protein sequence ID" value="SLM47291"/>
        <property type="gene ID" value="NSJP_1119"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1119"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="731"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="750" mass="85205" checksum="341E156DEEABFD65" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I306</accession>
    <name>A0A1W1I306_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47388">
        <property type="protein sequence ID" value="SLM47388"/>
        <property type="gene ID" value="NSJP_1216"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1216"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012235634" evidence="1">
        <location>
            <begin position="27"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="119" mass="13349" checksum="A429AE4C799A9FAE" modified="2017-06-07" version="1">MRTRSSDYCVPFCCALMLSVVSCTRAGEPLALDSHDPSHDGRSIAVYHANEAMTFSRKAENVADQATVYTRLFGPGSEWVVGATLLAQYYEEEAKEKARAARRYRDGYNRRTTHGEVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I360</accession>
    <name>A0A1W1I360_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47319">
        <property type="protein sequence ID" value="SLM47319"/>
        <property type="gene ID" value="NSJP_1147"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1147"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012325549" description="PRC domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="3">
        <location>
            <begin position="78"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="231" mass="25006" checksum="DA81ACB3E869FA38" modified="2017-06-07" version="1">MKQAKVTIIIGAAAAVLVCTGTMTPVRADSSNASSQVGGGMPSPDSVPRDKQTDLTGGKSGIPDEYSTTPVRQGKLKEITDSKWLNQTVTNKQGEKLGTIKKVLKDEKTQDIEYVFFEVTDSRYARPMKWSSFEQKGDKLVLNMSKEQLLPNVDRSESKDLSPDLAMYMEEIEHKREETKPYVGPGDGRGTQRVAPSSGSMGEDSAAGNLGDRGGPPGQAPGFENDAKKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3E7</accession>
    <name>A0A1W1I3E7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47363">
        <property type="protein sequence ID" value="SLM47363"/>
        <property type="gene ID" value="NSJP_1191"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1191"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="153" mass="17555" checksum="18807062E9285D19" modified="2017-06-07" version="1">MNDVEILLIEDNPEDVEITLRAFRKNNLTNKIHVVRDGEEALECLFSTGRYSEHSTCHQTRLILLDLKLPKVDGLEILQRCKADPRTKNIPVVVLTSSREEQDLIRSYNLGVNSYVVKPVDFPQFSDAVRQLGMYWILLNQIPAELPGQHQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3U8</accession>
    <name>A0A1W1I3U8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47513">
        <property type="protein sequence ID" value="SLM47513"/>
        <property type="gene ID" value="NSJP_1341"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1341"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007844">
        <property type="entry name" value="AsmA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032712">
        <property type="entry name" value="AsmA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05170">
        <property type="entry name" value="AsmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13502">
        <property type="entry name" value="AsmA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsmA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="AsmA_2" evidence="2">
        <location>
            <begin position="354"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="625" mass="67133" checksum="C927FF0D3EBD5BC1" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Y1</accession>
    <name>A0A1W1I3Y1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Phosphoenolpyruvate synthase</fullName>
            <ecNumber evidence="4">2.7.9.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.9.2" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1540"/>
    <dbReference type="EnsemblBacteria" id="SLM47712">
        <property type="protein sequence ID" value="SLM47712"/>
        <property type="gene ID" value="NSJP_1540"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1540"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="3">
        <location>
            <begin position="17"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="2">
        <location>
            <begin position="791"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="872" mass="95240" checksum="59A374F242047ED3" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Y4</accession>
    <name>A0A1W1I3Y4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidoglycan-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pal</name>
        <name evidence="9" type="ORF">NSJP_1513</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the Pal lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1513"/>
    <dbReference type="EnsemblBacteria" id="SLM47685">
        <property type="protein sequence ID" value="SLM47685"/>
        <property type="gene ID" value="NSJP_1513"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1513"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02204">
        <property type="entry name" value="Pal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039001">
        <property type="entry name" value="Pal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="OmpA-like" evidence="8">
        <location>
            <begin position="117"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="234" mass="25448" checksum="AF956C77AA719EF2" modified="2017-06-07" version="1">MNCRMGTIGRVTAICAVLMTSSGCGIKWLQSDGAEQAESRNGRTDSANGATDGSGQWQGLGVNPNFPDIARENLHGGELSGFSSNPAEERLASGYAASPRAYAGMNVMQHAELTKEERAAIDAGLQDVFFGYDQWTLSENGMASLNHDAAWLKQHPGALLKVEGHCDERGTTDYNVVLGDKRAKSARIHLIELGVNPKQVAIVSYGKERPFCQDHTETCYQQNRRGHVLLKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I431</accession>
    <name>A0A1W1I431_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HU, DNA-binding transcriptional regulator, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hupB</name>
        <name evidence="2" type="ORF">NSJP_1457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47629">
        <property type="protein sequence ID" value="SLM47629"/>
        <property type="gene ID" value="NSJP_1457"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1457"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="90" mass="9486" checksum="AA3B5CCFAA926997" modified="2017-06-07" version="1">MTKEELIAKMAASAGITKVAAGNALQAFTGAVTSSLKKGQRVSLVNFGTFTISRRKARLGRNPRTGETLRIPAAKVPKFSAGKVLKSAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I432</accession>
    <name>A0A1W1I432_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerate 2-kinase</fullName>
            <ecNumber evidence="3">2.7.1.165</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gck</name>
        <name evidence="3" type="ORF">NSJP_1539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.165" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1539"/>
    <dbReference type="EnsemblBacteria" id="SLM47711">
        <property type="protein sequence ID" value="SLM47711"/>
        <property type="gene ID" value="NSJP_1539"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1539"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043798">
        <property type="term" value="F:glycerate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037035">
        <property type="entry name" value="GK-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038614">
        <property type="entry name" value="GK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007835">
        <property type="entry name" value="MOFRL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025286">
        <property type="entry name" value="MOFRL_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039760">
        <property type="entry name" value="MOFRL_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227">
        <property type="entry name" value="PTHR12227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13660">
        <property type="entry name" value="DUF4147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05161">
        <property type="entry name" value="MOFRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF4147" evidence="2">
        <location>
            <begin position="14"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="MOFRL" evidence="1">
        <location>
            <begin position="333"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="445" mass="46849" checksum="8940D3511855803D" modified="2017-06-07" version="1">MTIRLPTSPVSTLLKRVLGRAINVAEGGAAVKRAVGRRGDVLTIASRRFDLRRYDRVVVLGAGKAAASMARALERLLGNRLEGGLVVVKYGHAVPTRRIVVYEAGHPYPDRAGFHAARRLMRAASTLSKRDLLIVLLSGGASSLLPAPVPGISLSDKQRVTRRLLRSGAGIQEVNTVRKHLSALKGGRLAAMTSARIVTLILSDVLGDDVSAIASGPTAPDPSTFRQAVLCLKRRRLWSSVSPSMRKHLDRGCRGLEVETPKTGAPCFRHVLNVLIGSGALAVSEAARAAREAGFRTVIHSINLTGEARLAGAEFGAMARDLRRHVKPGRKPCCVITGGETTVTVSGQGRGGRAQEFAVAAAQAIAGLPNVWVAAVGTDGTDGPTDAAGALVSGQTAAQALRNGIDLNAALKQNNTYPILKRLGAHIMTGPTGTNVNDLYVLLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I438</accession>
    <name>A0A1W1I438_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47770">
        <property type="protein sequence ID" value="SLM47770"/>
        <property type="gene ID" value="NSJP_1598"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1598"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="30" mass="3266" checksum="D4B7C767C080C894" modified="2017-06-07" version="1">MGTLGKGFLLWILGIPAGVIMLLWLLGILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I486</accession>
    <name>A0A1W1I486_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47837">
        <property type="protein sequence ID" value="SLM47837"/>
        <property type="gene ID" value="NSJP_1665"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1665"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="64" mass="7117" checksum="5223A38BE083D7CD" modified="2017-06-07" version="1">MVCLPHVEYECVIPQRMLGYRRFSIPKTRRNGSGDACGPIGYRMVLCGGLCSHAGTVDERSESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4I6</accession>
    <name>A0A1W1I4I6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_1679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1679"/>
    <dbReference type="EnsemblBacteria" id="SLM47851">
        <property type="protein sequence ID" value="SLM47851"/>
        <property type="gene ID" value="NSJP_1679"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1679"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="72"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="204" mass="22945" checksum="46141EC71768EF3B" modified="2017-06-07" version="1">MKKRVIRVVIVVCLVALGMVGWVGYQLFTTGFSAKTEPHRLEVLMARQIRHLAVPIAQRNAPNPVPLTPAVLKDARAHFADHCAICHANDGSGRTPIGKNVYPKAPDLREADTQSMSDGELFWAIHNGIRFTAMPAWGDDEPEKDMDSWKLVHFIRHLPNLTPEELDEMKGLNPKTRHEMEEEAEYDKFLEGDDTVGQADGHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4J6</accession>
    <name>A0A1W1I4J6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit I</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">nuoI</name>
        <name evidence="7" type="ORF">NSJP_1627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1627"/>
    <dbReference type="EnsemblBacteria" id="SLM47799">
        <property type="protein sequence ID" value="SLM47799"/>
        <property type="gene ID" value="NSJP_1627"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1627"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="192" mass="22023" checksum="E2321C1DD10E8B56" modified="2017-06-07" version="1">MSTAPVQTGSKRPSRFVEWLKTIVFYELLVGMKATMSHLLHYKPITVQYPHEKRALPDNYRGMLGLLRYDDGTEKCVGCDLCEAACPSRVIRVVSAEVPGEPTKRYSKEYYMDMTRCLFCGMCVKACPVDALGMSQEFEWAVYDKRQLHLNKQQLLAIGDRSFPVREKRLELQHPNVAFFNVSFGHVPQKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4M9</accession>
    <name>A0A1W1I4M9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47968">
        <property type="protein sequence ID" value="SLM47968"/>
        <property type="gene ID" value="NSJP_1796"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1796"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="119" mass="13783" checksum="0082DB18A8397D05" modified="2017-06-07" version="1">MPHLSVSDVESRLSTVQCAICKGSSFGIDQRFMQSDGEWRGVCKKCFYSFPVYTDMEFYLRTQPDVPYRLKEISCTACNHRGVSLDFRITMSVREAIYFVTCLNCKRAFPEKSFLEAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5B9</accession>
    <name>A0A1W1I5B9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48121">
        <property type="protein sequence ID" value="SLM48121"/>
        <property type="gene ID" value="NSJP_1949"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1949"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="112" mass="12055" checksum="EF6B1566B3CEDE9F" modified="2017-06-07" version="1">MLCPTSLSVKFGLKMRRTVVILRIGRSNRCGNGSRISIDESAGAALHDLSRVILGKPSPIGELIGMAFYSSATMEGVQNSELELNIGRRGKNVNLCTATDEARHINDTIQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5F4</accession>
    <name>A0A1W1I5F4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2076"/>
    <dbReference type="EnsemblBacteria" id="SLM48248">
        <property type="protein sequence ID" value="SLM48248"/>
        <property type="gene ID" value="NSJP_2076"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2076"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="140" mass="15625" checksum="F4D79831406AA078" modified="2017-06-07" version="1">MDDECFQMTQPDQPTGHTILVGVTDIFFYTKVRDALRPRGFRLERARSQQDIAGISSTGSPAAVILNMNDDVLNAFQALETLKADARTKKVPVLAFANHEEVDTWNRAKSLGVTKIVSRNEFSARTRELVEEVLSTLNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5I6</accession>
    <name>A0A1W1I5I6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48272">
        <property type="protein sequence ID" value="SLM48272"/>
        <property type="gene ID" value="NSJP_2100"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2100"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="87" mass="10008" checksum="C56CF3555ACCD1FD" modified="2017-06-07" version="1">MKSALRRKAEPVVEEIELGPLTPRQRDILRLVSIGHTNREIATVLQISVRTVEVHRFNLMRRLNVRNVAQLLRRALQLGLLSKSFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5M9</accession>
    <name>A0A1W1I5M9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48241">
        <property type="protein sequence ID" value="SLM48241"/>
        <property type="gene ID" value="NSJP_2069"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2069"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="198" mass="21620" checksum="B6D4268948A63244" modified="2017-06-07" version="1">MTLTIHILPARNPTEVDAMNIRLTSFACAMLLIPLWMCPALAKAQTPRQQAEQELTRKAPNAGLQACSLITRADVKNAAGRDPFVDAEPAGQGGWMCNIGISELKVYAGPKSWEAWESTLKSFKMDKEPQTPAPGFGERAYFLYPKPANKYQSNIAVLVTKSGNHTLVLSLDAPQGKPAESMRPALESLMKTILARLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5P2</accession>
    <name>A0A1W1I5P2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable tRNA sulfurtransferase</fullName>
            <ecNumber evidence="6">2.8.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sulfur carrier protein ThiS sulfurtransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thiamine biosynthesis protein ThiI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA 4-thiouridine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">thiI</name>
        <name evidence="9" type="ORF">NSJP_2123</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:13337"/>
            <dbReference type="Rhea" id="RHEA-COMP:13338"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136798"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]</text>
            <dbReference type="Rhea" id="RHEA:43340"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12910"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiI family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.4" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2123"/>
    <dbReference type="EnsemblBacteria" id="SLM48295">
        <property type="protein sequence ID" value="SLM48295"/>
        <property type="gene ID" value="NSJP_2123"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2123"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140741">
        <property type="term" value="F:tRNA U4 sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01712">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00021">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003720">
        <property type="entry name" value="tRNA_STrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00342">
        <property type="entry name" value="TIGR00342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="8">
        <location>
            <begin position="59"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="402" mass="44987" checksum="BF8FBDF7F6854155" modified="2017-06-07" version="1">MKHVIIHYHELALKGRNRDFFERRLIQNIRSSLRDLRITRVESLRSRIRIVLPTDANHLQVADRLRRVFGIANFSLAEAVELNLANPNLDGLAGRIGKALLHHNDPFESFRVTARRADKRLVLTSMDVERAVGAHVHQVTGKKVRLKNPDLTVYIHLLTKEAYFSLDKIEGPGGMPVGVSGTVACLISGGIDSPVAAYRMMKRGCNAVFVHFSGRPLVSRASEEKVRELVQILTAYQYRSKLYVVPFGTIQREIVAQAPAPYRVVLYRRLMVRIAGELAQREKCWGLVTGDSLGQVASQTPENLTVIEEAAEVPILRPLIGMDKTEITRQAEHIGTFTTSIEPDEDCCSLFTPPHPSTRTRIDDIRRIERSFDTGGLVKQGVDAAEPSEFTFPLRQAPTPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5S7</accession>
    <name>A0A1W1I5S7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-oxoglutarate carboxylase large subunit</fullName>
            <ecNumber evidence="5">6.4.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cfiA</name>
        <name evidence="5" type="ORF">NSJP_2182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.4.1.7" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2182"/>
    <dbReference type="EnsemblBacteria" id="SLM48354">
        <property type="protein sequence ID" value="SLM48354"/>
        <property type="gene ID" value="NSJP_2182"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2182"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034029">
        <property type="term" value="F:2-oxoglutarate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005776">
        <property type="entry name" value="OadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01108">
        <property type="entry name" value="oadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="4">
        <location>
            <begin position="45"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="581"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="651" mass="71499" checksum="00B99649D2EFB334" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5U1</accession>
    <name>A0A1W1I5U1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48360">
        <property type="protein sequence ID" value="SLM48360"/>
        <property type="gene ID" value="NSJP_2188"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2188"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="67" mass="7775" checksum="C294F70635673F86" modified="2017-06-07" version="1">MIYWIHIARSIDRVTLHNDRCSEVPSTQSSTDYWAGGWFDYPDKERALAAMEQAGTTDQRRCPLCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5W0</accession>
    <name>A0A1W1I5W0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2159"/>
    <dbReference type="EnsemblBacteria" id="SLM48331">
        <property type="protein sequence ID" value="SLM48331"/>
        <property type="gene ID" value="NSJP_2159"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2159"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="140" mass="16620" checksum="D10A7BB5C5938994" modified="2017-06-07" version="1">MNEDDKSRHEIIMNSIQNVSLERFDALQAHDMLFIDSSHVAKVGSDVAHLLTNVLPRLHKGVLVHFHDIFWPFEYPEQWIREGRAWNECYVLRAFLQFNRMFRIRFFNSYLAIHHRARLEQILPLAMKNTGGSLWIEKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I638</accession>
    <name>A0A1W1I638_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48476">
        <property type="protein sequence ID" value="SLM48476"/>
        <property type="gene ID" value="NSJP_2304"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2304"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="458" mass="49054" checksum="07D806844096A696" modified="2017-06-07" version="1">MLEDIAQGIERLQSFIPQIEDLGRDGFPYLEGARARTELQLKECIKKTFGDKSPEFQAYRQHRLSVETPADTKQTVALLKSLIGALEDKKLELQGLKPPPVVETPPPPPATAPTAPRPSLTLVPSTTPSAQVTITPAAPVLPPPITMSVALTTNLDMTRQQAAPEPPPSMPAAPQSPAAPPTGSPQTPANQHNAAILTAVYPPSTPAPSLSAPLAVSAPKPVTLNQAVAPVPPQPSLQETQPMTPTVAPLPAPASMPTPSVAPETKLAAPDLIPPGATPVSTVPKALFSESSPASKPTSSASGEPGADPLEMVKSLCKRFHMIVRQLRLRGEYRATLNVEDELDAQDLLHALLRVSFDDIETSEWVPDYANGTPRVRFLLNDGRLAVIVKKTRSGLNTRDLMEQLRADIEHCRTLKGCSTLLYFVYDPEGRIGNPRGLETDLISISDQLTVDVYVAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6D6</accession>
    <name>A0A1W1I6D6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory protein, P-II 2, for nitrogen assimilation by glutamine synthetase, regulates GlnL (NRII) and GlnE (ATase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glnK</name>
        <name evidence="4" type="ORF">NSJP_2400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the P(II) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2400"/>
    <dbReference type="EnsemblBacteria" id="SLM48572">
        <property type="protein sequence ID" value="SLM48572"/>
        <property type="gene ID" value="NSJP_2400"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2400"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017918">
        <property type="entry name" value="N-reg_PII_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039144">
        <property type="entry name" value="GlnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00638">
        <property type="entry name" value="PII_GLNB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="O-UMP-tyrosine" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR039144-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602187-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="112" mass="12369" checksum="259F37DCA97DF795" modified="2017-06-07" version="1">MKLVEAIIKPFKLDEVKDALLEIGVQGMTVTEVKGFGRQKGHKETYRGQEYTIEFVPKVKLEVAIQDNQVPRVLETIARAAKTGSIGDGKIFVRDLNAAVRIRTGETGETAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6F4</accession>
    <name>A0A1W1I6F4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">groS</name>
        <name evidence="3" type="synonym">groES</name>
        <name evidence="5" type="ORF">NSJP_2436</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2436"/>
    <dbReference type="EnsemblBacteria" id="SLM48608">
        <property type="protein sequence ID" value="SLM48608"/>
        <property type="gene ID" value="NSJP_2436"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2436"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="99" mass="10977" checksum="12D4F1A8F1683BCF" modified="2017-06-07" version="1">MSTAAKEKKNVAKGFQPLGDRVFITYTEELERTAGGIYVPDSAKEKPQRGVVQAVGKKVENVKVGDQVLFDKYSGSKLRIEDEECLILKEEDILGIFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6J1</accession>
    <name>A0A1W1I6J1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48648">
        <property type="protein sequence ID" value="SLM48648"/>
        <property type="gene ID" value="NSJP_2476"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2476"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="148" mass="16091" checksum="CD5767E5FAF9DE89" modified="2017-06-07" version="1">MAKAKKQPAKKKMKASGKRAAKTPAKKSSGKSSAAKAKKPSVKEPVRKAAPAPKPAAPSVKKPVKPAVDDEIKKPVSSKPTAKPPVTEPKEAELDEDEMGDEELEMGGDGEMEEDMEEDLTLDDDEEDVDYLEKSEDLLDDSDDYRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6L9</accession>
    <name>A0A1W1I6L9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2462"/>
    <dbReference type="EnsemblBacteria" id="SLM48634">
        <property type="protein sequence ID" value="SLM48634"/>
        <property type="gene ID" value="NSJP_2462"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2462"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="267" mass="30235" checksum="7B191D04B69D67C5" modified="2017-06-07" version="1">MLKNGLSEELNRQGNEHFSLGHYTEAYTCYAKALECDRMTGDQRALAATLGNLGNICAVSGRRDAAQDYYQEVLELQKVFGDEKGIGTTLANLGNLRADAGEWERARAYYLEALDLMTKTHDEAAKAVLYSDLGLIARETGQFEEAIRCYERSLVLMRRLGNQGGTADAWRMMGRTFLMQRRHDDAIACCQTSQSIAERAHDELRAGGARYVLAQCYEELGRFDEAVALLERVVEMDRKYQLPKLDENTRRLQDLRERKERAMGQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6M9</accession>
    <name>A0A1W1I6M9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2516"/>
    <dbReference type="EnsemblBacteria" id="SLM48688">
        <property type="protein sequence ID" value="SLM48688"/>
        <property type="gene ID" value="NSJP_2516"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2516"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021747">
        <property type="entry name" value="DUF3313"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11769">
        <property type="entry name" value="DUF3313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013275116" evidence="1">
        <location>
            <begin position="26"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="237" mass="25985" checksum="DCB48610B7B5D553" modified="2017-06-07" version="1">MHRFSSILFILVVTLLAACSPTKQARSVDTSGFLGPIYPLMHKGEDGEALLLYKNPKVATIPRGTYKKMLLDHVQVWGPPTTDPDRQARAQKIADLLYTLAYDSMSQDYEMASEPGPGVLHAQVAITRADPAYVVLRAVSTIPAPMNAFAVASMLKNIGTGKPLFVGDASLELKLSDSQTGEVLAASADRRVGNKRLDADSFDSWDDVHKALAYWVEKARYRLCQERHAQNCVPPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6P1</accession>
    <name>A0A1W1I6P1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">rplO</name>
        <name evidence="10" type="ORF">NSJP_2357</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2357"/>
    <dbReference type="EnsemblBacteria" id="SLM48529">
        <property type="protein sequence ID" value="SLM48529"/>
        <property type="gene ID" value="NSJP_2357"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2357"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="9">
        <location>
            <begin position="27"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM48529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="149" mass="15747" checksum="15F6F93EE4EDEA74" modified="2017-06-07" version="1">MNLHELAPAKGAKKKRKRIGRGPGSGHGKTATKGHKGLLARSGGGKGAGFEGGQMPLIRRVPKYGFTNPFRKEFAIVNLKSLVDLAEQGTITPQTLVDAGLVRRLTLPIKILGNGELKKPLVVQAHKFSKSAEAKIQAAGGRVEVIPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6S0</accession>
    <name>A0A1W1I6S0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpsZ</name>
        <name evidence="5" type="synonym">rpsN</name>
        <name evidence="6" type="ORF">NSJP_2351</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2351"/>
    <dbReference type="EnsemblBacteria" id="SLM48523">
        <property type="protein sequence ID" value="SLM48523"/>
        <property type="gene ID" value="NSJP_2351"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2351"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="61" mass="7127" checksum="37E09E92B2A73A06" modified="2017-06-07" version="1">MSRLALRNKCAKKPKFSSRAYHRCGICGRVHGFLRRFKMCRICFRLLSLKGEIPGVRKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6W6</accession>
    <name>A0A1W1I6W6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lytic transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_2590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2590"/>
    <dbReference type="EnsemblBacteria" id="SLM48757">
        <property type="protein sequence ID" value="SLM48757"/>
        <property type="gene ID" value="NSJP_2590"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2590"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="6">
        <location>
            <begin position="72"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="511" mass="57698" checksum="ED05EAF24620F295" modified="2017-06-07" version="1">MGRMLERDLIRNSVVKRLFLATALFGSLFLVGLPTPQSLAAALQSSDDHDLVQSSILRPWTGDLDGMVERRVIRALVAPSRTSYWLNGARQTGAEYELLKAFQEEINAKYQSRNKHILVHVVFIPTSRDQLIPALLEGRGDIAAGILTVTPERLEKVDFGEPFFRGVKEIVVTGPASPNITSLSDLSGKEVFVRKSSSYWSHLERLNEQFAQEQKAPVILKPAPEDLQDDDLLEMVNAGLVEIIVVDRYQALLWSKVFKKLVAHKGVVLNAGGDFAWMLRKDSPKLKAEIDEFAKKYGRKSEFGNALVKKYGGDGNPRIVKQATSGTEIKKFSKTVDLFRKYGAQYEMDYLLMIAQGYQESLLDQNARSNVGAVGVMQLMPATGNEMKTGDITQLEPNIHAGIKYVRYIRDQFFENEDMDSRNKILFSFAAYNAGPARVQKLRKEAEKRGLNPNVWFNNVELIAARRIGEETVTYVANIYKYYIAYKLVEEQRAEKEKRRADLQHDLSGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6Y1</accession>
    <name>A0A1W1I6Y1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_2587</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2587"/>
    <dbReference type="EnsemblBacteria" id="SLM48754">
        <property type="protein sequence ID" value="SLM48754"/>
        <property type="gene ID" value="NSJP_2587"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2587"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018003">
        <property type="entry name" value="Insecticidal_toxin/plasmid_vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041079">
        <property type="entry name" value="Neuraminidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040840">
        <property type="entry name" value="TcA_TcB_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18413">
        <property type="entry name" value="Neuraminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18276">
        <property type="entry name" value="TcA_TcB_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03538">
        <property type="entry name" value="VRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Neuraminidase" evidence="5">
        <location>
            <begin position="2040"/>
            <end position="2176"/>
        </location>
    </feature>
    <feature type="domain" description="TcA_TcB_BD" evidence="4">
        <location>
            <begin position="3105"/>
            <end position="3391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="2006"/>
            <end position="2040"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="2926"/>
            <end position="2953"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="3114"/>
            <end position="3141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="3571" mass="394704" checksum="7B3FA6CCA5D1ED57" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I790</accession>
    <name>A0A1W1I790_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48876">
        <property type="protein sequence ID" value="SLM48876"/>
        <property type="gene ID" value="NSJP_2709"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2709"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="12"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="111"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="170" mass="20028" checksum="36609B8A7F258C40" modified="2017-06-07" version="1">MDNQLAAERFALFREYYDELVRYLTVRLRSRDQAMDVAQETFLRVLTHEPSLPINKPRAFLYRTALNLTVDLFRRQQRHVEEPLDEESIEAALIVPAEQEAHTEAKEQVRLLYEAVMELPTRCRQVFLLHKFKDYSQAEIASRLGISISMVEKHVLKATAFCRERFKDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I795</accession>
    <name>A0A1W1I795_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Phosphate ABC transporter, periplasmic phosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2725"/>
    <dbReference type="EnsemblBacteria" id="SLM48892">
        <property type="protein sequence ID" value="SLM48892"/>
        <property type="gene ID" value="NSJP_2725"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2725"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010708734" evidence="1">
        <location>
            <begin position="28"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="2">
        <location>
            <begin position="47"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="360" mass="39260" checksum="36568BDD1EC6A2E0" modified="2017-06-07" version="1">MLHTMLKRGAWLVGIFALAVTVDPAAAEQGGPFASVTPDNELARYAPQAQIKGSLKIQGSETMYPLLSRLSLEFQRRQPNVRIEVRGGGSSKAIEEFLQPPLQKTGKVMLLEERSQHFSLVATSRELFDSELKEFVAQHDYEPMAVPVAVDAVAIYVHKDNPLNALTLEQVDAMFSSTRLRGHKTPITQWGQLGLSEGWTDAPIQLYGRDRKSGTRAFFQEHCLGGGEFIPSVHENPGAASVILSLSRDQLGIGYSGLGLESSMVRAVPLAEAAGTPFITPSPATVADQSYPLRRMLYLYLDKTPKTSLPPAVKEFLAFLMSQDGQQAVVKAGFFPLPAQQINKSAVALDRTTGSAPVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7F2</accession>
    <name>A0A1W1I7F2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2684"/>
    <dbReference type="EnsemblBacteria" id="SLM48851">
        <property type="protein sequence ID" value="SLM48851"/>
        <property type="gene ID" value="NSJP_2684"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2684"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012415917" evidence="2">
        <location>
            <begin position="22"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="257" mass="28811" checksum="A0CE5B4E4F3AED55" modified="2017-06-07" version="1">MKALRLCAITGLILSGCASWAPEPSRTQPYFTVDQADAKSIHNLVKKQDAMIAKCSDHNSCDHAYFTRALMSLYESHDAAVKNFEKVIAVAPRSQWASSSRLWLQLLQQYPTPIERSWLSSVAGAPAVSEGQVVLGQASDRLVRDLLDRELIIQQLRTTRDADAQVLDQLQRDLADRDRKADALIGNKKESQKTPVESGTIQSLQKQLAEREKKIDELYNQLEALKRIDQETREKIRPIRPPSTVAPLPTPESTTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7P8</accession>
    <name>A0A1W1I7P8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2666"/>
    <dbReference type="EnsemblBacteria" id="SLM48833">
        <property type="protein sequence ID" value="SLM48833"/>
        <property type="gene ID" value="NSJP_2666"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2666"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007463">
        <property type="entry name" value="DUF507"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04368">
        <property type="entry name" value="DUF507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="91" mass="10318" checksum="5B2240BE53D87EE3" modified="2017-06-07" version="1">MLSDDKVNHLSHVILQAVKKSSLAAVTADDGRLLKQIKRTLAAELEAEEEIDRKIRAKLTSYSRGIVEGSPEWDVLYRKTFEEETKKYAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7U9</accession>
    <name>A0A1W1I7U9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49102">
        <property type="protein sequence ID" value="SLM49102"/>
        <property type="gene ID" value="NSJP_2935"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2935"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="113" mass="13188" checksum="3C969A4B6096EF3E" modified="2017-06-07" version="1">MRDEARFTPIGRPLRLLPAYLGINSIGEAIKTERRRRILWLEILVNDQLDLSPWKSDPAVEAAYTTACRWYTQYRRLITYLLHRTPLPSDTGPIDFCDYRAFAEALSFVCPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7X1</accession>
    <name>A0A1W1I7X1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane bound O-acyl transferase MBOAT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_2981</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49148">
        <property type="protein sequence ID" value="SLM49148"/>
        <property type="gene ID" value="NSJP_2981"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2981"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM49148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="470" mass="53693" checksum="32C09D25C3EF1314" modified="2017-06-07" version="1">MLFNSPIFLFAFAPLFFVIYFSLKPSLRNPFIVASSIAFYAWGEPSFIGVVLFSASGDWFIGNALYLANREEKRRWLLVLGICLNIGILAYFKYAGFFVDNLNDLLFNLNLTPFPAMTVALPIGVSFIVFEKITYLVDIYRRLGPPASSITSYLLYVLLFPKLLAGPIVKYHDICNQLRARTPQLEDVTEGLLRFLIGLGKKVLLADTMQEAVDQVFGLSAADLGTLNAWLGTVCFTLQIYFDFTGYSDMAIGLARMMGFRLLENFNRPYIATSITEFWRRWHISLSTWIREYLYIPLGGNRVPAWRMYCNLWLCFVLCGLWHGASWTFVLWGVFHGTLLIVDKIWWLEAQKSLPRLLNVLTTFLLVMFGWVVFRAESFDQALFYFQALLGLTSSEGTFIYLGNNVKAAMAAGLLICFLPATPWLERWKSAVVAWPWKQECQLGLALVLLVISVAKISITTFNPFMYFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I813</accession>
    <name>A0A1W1I813_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="6">1.1.1.169</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_2977</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2977"/>
    <dbReference type="EnsemblBacteria" id="SLM49144">
        <property type="protein sequence ID" value="SLM49144"/>
        <property type="gene ID" value="NSJP_2977"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2977"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="4">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="5">
        <location>
            <begin position="177"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_molyb" evidence="3">
        <location>
            <begin position="352"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="453" mass="49356" checksum="3F8FD54BB33DE8E2" modified="2017-06-07" version="1">MKQIMMVGAGSVGGYFGVQLAKANPDVSFLLRPRTLAAVKQHGLTVRSAGGTVTVRPAAASDPRDLPKPDLVILGVKAYDLDEVMDQIEPVIDDRTVLLTLQNGIDTEDRIHARLKRDCVVGGVAFIYSKIAEPGVIDHYKKGAIAIGELMGHESERLLQIRDLFAAAGVPCQLSKDIRRSKWEKMCWNCVFNPITVLIDDKVAQALDHPEMTGVIRQIVGEVAAVSAALKVPLPPDMADRVVKWTQEIRDIHTSMYDDWKAGRRTEIRNLNGYIVDQGRMLGIPTPVNEALTAMIKTVTEKARNGPEIIRIDGAVVQAVSLERSALRQLPTEHQVEDVGAVMPGMRGRAIRVNGLLELPALSLDADHVTFHAFDGKYAATLTLPQAREHGLVLYELDGEPIPESKGGPFRLVTPGLGDLCANVKGLGRIEVRAGKGRDTRPSERPPQCAPPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I826</accession>
    <name>A0A1W1I826_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49198">
        <property type="protein sequence ID" value="SLM49198"/>
        <property type="gene ID" value="NSJP_3031"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3031"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="392" mass="41546" checksum="1EFBD999CAA91571" modified="2017-06-07" version="1">MTLPPSRQTARLPRLLRMFVCLSVVIWTGLVVCLAAAVEFQVPQQYATPAAYSMAGSTVRGERSNPAIGYWNGATIVWRDALDREPVQDKGFLGTGKYGYAMRWLSNIDQRYARIDDSEPLDIRTRAGSPGTPQGAMRGYGTLIRLSVPLSQNEKQVLGLRFSGPPQDKGSGSWRQQFNAQSTLRISKPGARAAEKMRVRVVGEIAGQSSGKDLQHSALEARIVIDQVADLRISGPNPNPTPRATIDPYVDVPVNTDLRWQMSFSIYASGQRGTTDLAVALTKQEITLELPAASDSFTSAPPPVKPLTGASVPVPNQTGAVVIPGSPSGTTMTGPPPGSTLSTPQPGNGGQPLGTQRNLDGPGSGAASSPPPGAFVIPRGVEAADESAEQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I859</accession>
    <name>A0A1W1I859_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49175">
        <property type="protein sequence ID" value="SLM49175"/>
        <property type="gene ID" value="NSJP_3008"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3008"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="95" mass="10581" checksum="E654E23D03311BC5" modified="2017-06-07" version="1">MPLTRGSQRRLLTVLTFAFLCLCVLMQVLGTTLTLWACEFESDHPSNLLFEGFSLPVSYLELHPPDITGLATERLPEFRQSGDGHTLLRPPNPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I885</accession>
    <name>A0A1W1I885_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2902"/>
    <dbReference type="EnsemblBacteria" id="SLM49069">
        <property type="protein sequence ID" value="SLM49069"/>
        <property type="gene ID" value="NSJP_2902"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2902"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="93" mass="8500" checksum="F678EA342F26DF08" modified="2017-06-07" version="1">MDTTGLIINLISGAVGGNAAGAAMPDKSLGTLGNSLAGLLGGGVGGAIIEALAPALSQGGDLGSIIGNIAGGGVGGGLLMIVASLVKNAFAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8E0</accession>
    <name>A0A1W1I8E0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49287">
        <property type="protein sequence ID" value="SLM49287"/>
        <property type="gene ID" value="NSJP_3120"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3120"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="90" mass="10726" checksum="E6BC455340021464" modified="2017-06-07" version="1">MHREEKTFRLRFSLEVSFPDDFDGEEDEFAWAREWEGRIKPELLKDVFESLRRHPAWNAHIRNRGISPADEIEIVVSRDFSGPQPFRIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8E1</accession>
    <name>A0A1W1I8E1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49276">
        <property type="protein sequence ID" value="SLM49276"/>
        <property type="gene ID" value="NSJP_3109"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3109"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="247" mass="27388" checksum="E622A9C25CDEDE42" modified="2017-06-07" version="1">MSERIIEGLPDDTQRVVQSYAKDVKQAFGERVEGLLIYGSAVRGEFLPGRSNLNMLLLMTSYNSEALRTYAPLHKRWSKEQIVVPLFLTEQELNDSSALFPLEFLEIQDWHRVLGGRDPFVGSHIDRSRLADQVLQGFAGHALRLRQRYAEAGGADDAVTILLPLSVTSMVPLLRGLQRMLSRPVSAHSDAVISDIAGHFKIDLQGLLDALALKRGQISPGPSEVPRLFDRYLQAVSSLSATALTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8L8</accession>
    <name>A0A1W1I8L8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Peroxiredoxin</fullName>
            <ecNumber evidence="8">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_3168</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.15" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3168"/>
    <dbReference type="EnsemblBacteria" id="SLM49335">
        <property type="protein sequence ID" value="SLM49335"/>
        <property type="gene ID" value="NSJP_3168"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3168"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="3"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="211" mass="23644" checksum="94038D68115C03F7" modified="2017-06-07" version="1">MALRLGDEAPNFTAETTEGTINFHEWLGGGWGILFSHPKDYTPVCTTELGTVAKITPEFKKRGVKVIAVSVDPLDSHKGWINDINETQHTTMNYPIIADPDKKVSTLYDMIHPNAMDNMTVRSVFIIGPDKKIKLTLTYPASCGRNFDELLRVIDSLQLTSKYKVATPANWKDGEDCIITPAVNNDEAKTLFPKGFKTIKPYLRYTPQPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8U5</accession>
    <name>A0A1W1I8U5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3238"/>
    <dbReference type="EnsemblBacteria" id="SLM49405">
        <property type="protein sequence ID" value="SLM49405"/>
        <property type="gene ID" value="NSJP_3238"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3238"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="31"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="282"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="478" mass="52864" checksum="435EE03515FC6A39" modified="2017-06-07" version="1">MDPAELLNLPLFANLSQDERTCLDQGEVLSVPAGTMVTREGESVEYFYVILEGEIRVTKNYDGQEVVLALHSTGKFFGEVPLLLDMPYFVDSETRTACRLLRYSKEQFWSVMRICPTVAKEILRTMAARVRGLEGYSQQREKLVSLGTMAAGLAHELNNPAAAARRAAADLVTVASGLPSLACQLNKQQLSAEQSETVAQILRDLASRPSPSVPPDPLTRSDREEDILKWLEQHPIDNAWNLTGILVGAGLDRTWLERISNRFPNDAIGDVLRWMTGTLSLRDLTQQVERSTSRIADLVNAVKAYSYEGRAPIQDVDIHEGLESTLTMLSHKLKSVTVVRDYDRSLPVIPAYGNELNQVWTNLIDNAIDAVGGKGEVRIRTAHEDHHVLVEIHDAGSGIPKEVRPHLFEPFFTTKGVGKGTGLGLIISYRIVTDRHKGEIDYDSEPGHTVFRVRLPMMRKPLATSAGPSDPPVESAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8X0</accession>
    <name>A0A1W1I8X0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">linX</name>
        <name evidence="1" type="ORF">NSJP_3287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49454">
        <property type="protein sequence ID" value="SLM49454"/>
        <property type="gene ID" value="NSJP_3287"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3287"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="249" mass="26252" checksum="098EFD9EE5A024FD" modified="2017-06-07" version="1">MRPRLAGKVAVISGGGRGLGLATARLFAREGASVVIGQRDRVEGEQAVTSMHADGERACFSALDVTQEDSWQQVIHTALETFGRLDILVNNAGVLQMEGVEDLTQDVWDHTIAVNQTGTWLGMKAAIPAMRKTGGGSIVNVASIAGLIGHGQVFAYQASKGAVVIMSKSAAIEYAREGIRVNTVIPGPADTAMFSQVEQALAQQVKNQIPLGRIARPEDVAYGVLYLASDEAAYVTGTELVIDGGFTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Z4</accession>
    <name>A0A1W1I8Z4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49465">
        <property type="protein sequence ID" value="SLM49465"/>
        <property type="gene ID" value="NSJP_3298"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3298"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="57" mass="6618" checksum="17CEBDD7BC6049DE" modified="2017-06-07" version="1">MVSSQSVRFSGCKPGRWHGRAILKENGRIYLTKGITLWTSHRRTRGRDRRPESGYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I920</accession>
    <name>A0A1W1I920_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3329"/>
    <dbReference type="EnsemblBacteria" id="SLM49496">
        <property type="protein sequence ID" value="SLM49496"/>
        <property type="gene ID" value="NSJP_3329"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3329"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007383">
        <property type="entry name" value="DUF445"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04286">
        <property type="entry name" value="DUF445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="415" mass="46581" checksum="D709494C81042F6B" modified="2017-06-07" version="1">MDGDVPIIPHDPSAAFRRTRLAATGLLLFMAALFLAALFGEQRYPLLSWLRAFAEAAMIGALADWYAVTALFKQPLGLPIPHTEIIPRNKDRIASSIGSLTQRKLVTPEAIGRLIESWRIPDELTSLLVDPQRRRGLTQELAGWLARLLETSEDAAVQRFIRHLATKLLDGLTVAPLTRQLVSGVLQSLQRNRLVNDALALAIDYVDTHRDPLSNMIAQKLPWSRLLGLVRLDKRVARRMIGWFRSVLRDVQDHPDDSMRQSAEQWFTSSDGASRQVTAIKELLMSPVMLQIIDGSWHSLKEWLLADLKQEHSETRAYLDAALAGLGDTLKRDEDAVRIFQEGLQNLVVELATRHRDRIGELVTNTVRDWSVAHMVETIEREVGKDLQFIRINGTVVGGLIGLLLHAVAMLFGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I921</accession>
    <name>A0A1W1I921_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="6">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">lysS</name>
        <name evidence="8" type="ORF">NSJP_3212</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3212"/>
    <dbReference type="EnsemblBacteria" id="SLM49379">
        <property type="protein sequence ID" value="SLM49379"/>
        <property type="gene ID" value="NSJP_3212"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3212"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="173"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="493" mass="55938" checksum="8F9F6CEE1BA3B419" modified="2017-06-07" version="1">MDELNEQRQQRIKKLEQLRASGVAPYGGRFEIKDRAERLIAVHGEKSKEVLEQEKITCTFAGRVVALRRFGKAAFAVLQDGSDRLQVYLKKDLLSPQAYAVTEQLDLGDWIGVTGTLFRTKTNEFTVEVKELTFLSKALRPLPEKWHGLTDVETRYRQRYVDLIANPDVHGIFAARSRIIAGIRSFLIDRGFLEVETPMMHPIPGGAAAKPFVTHHNALGVDLYLRIAPELYLKRLIVGGFPRVFEINRNFRNEGISTIHNPEFTMLEFYVAYADYQDLIALTEQLVSTLASQLLGKTTIDYQGKAIDLAPPWRRWSYHQAILEVNGLDESVLRDRDKALAAAKTLNVAVDPAWPLFNIVNEIFEETVEPNLQQPTFVTDYPIEISPLARRKDSDPALTDRFELYIAGREIANAFSELNDPLDQRERFEGQAAQREAGDEEAHLVDEDFLRALEYGMPPTAGEGIGIDRLVMLFTNQASIRDVVLFPQLRPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I989</accession>
    <name>A0A1W1I989_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine protease do</fullName>
            <ecNumber evidence="6">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">degP</name>
        <name evidence="6" type="ORF">NSJP_3388</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.-" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3388"/>
    <dbReference type="EnsemblBacteria" id="SLM49555">
        <property type="protein sequence ID" value="SLM49555"/>
        <property type="gene ID" value="NSJP_3388"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3388"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011782">
        <property type="entry name" value="Pept_S1C_Do"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02037">
        <property type="entry name" value="degP_htrA_DO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012348145" evidence="4">
        <location>
            <begin position="42"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="260"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="369"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR611782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="473" mass="50299" checksum="8E9ADEFB0A261E13" modified="2017-06-07" version="1">MVYTAGTMSPVVSNRRRSVLPAVLAALVVSAVAVRCADVQAAEAGKTTGLQMLEEIQAVITDLAEATKPSVVNLFPVTPSGKGRDFLQDRTPNSPGSGSGVLVDSDGHIITNNHVIGDASEVEVRFSDKSKLIAQVVGKDPDTDLAVLKVTSDHPLPYAKFGDSSGVRVGQWVLAVGNPFGLDRTVTLGVVSGIGRENVNLSRYENFIQTDASINPGNSGGPLFNLRGEVIGINTAIINFAQGIGFAIPSNMAKQVLQQLVAQGRVVRGWLGVGIQPLTPELARKFGVTDNEGVLVNEVFEKDPAAVAGIKPGDIITRIEGTVVDTPNRLSRVVAGLQPGVMTKVEVVRDKKRMVLDVALSERRDQAVVASLPPSRTDVKLGLDLQDLTAALADKFRLRETRGVLITKVEPGSLAQSEGLREGDLIKEVNRVDVGSVGEFTAAISKVRRGETVLLRVLRESRAFYVVLKAGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9B7</accession>
    <name>A0A1W1I9B7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">zf-RING_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3460"/>
    <dbReference type="EnsemblBacteria" id="SLM49627">
        <property type="protein sequence ID" value="SLM49627"/>
        <property type="gene ID" value="NSJP_3460"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3460"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003743">
        <property type="entry name" value="Zf-RING_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02591">
        <property type="entry name" value="zf-RING_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-RING_7" evidence="3">
        <location>
            <begin position="199"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="258" mass="30004" checksum="984FF5B9741A01D9" modified="2017-06-07" version="1">MNQHLSPLIELQKLDLRIMEISEQRRKIPDRMHQVETPLRDARQVLQETMVSMEAVVKERRGYERDVEVQDAHNDKMRARLSEIKTNKEYQAHLFELQMANKKKSEIEDKVLACMEKIEQLQRTIKESQERVEAVEHTFKQEKRVLDELEGRLSHELAELEIQQRQQATHVERGLLDRYTKLKSARKDQALAAIKGGMCAGCRLQIPPQLVAEVKRSQGLHTCPYCHRMLYWEAEPTTDSKPPAESAKDNSLEVGESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9H8</accession>
    <name>A0A1W1I9H8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein KdpE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kdpE</name>
        <name evidence="5" type="ORF">NSJP_3489</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49656">
        <property type="protein sequence ID" value="SLM49656"/>
        <property type="gene ID" value="NSJP_3489"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3489"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="129"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="129"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="234" mass="26097" checksum="2D73440CFBECC949" modified="2017-06-07" version="1">MAQGARILVVDDEPQIRRSLQVNLENRGYAVETAVSGEEALRSFTYRRPDVVIVDLLLPDIGGVEVTRRIRSSATVPIIVLSAIGDESKKVEALESGADDYMTKPFGTEELLARIRSVLRRAAGAHSARPVFIAGRMCVNFDRREVLLDDQPVKLTPTEYDLLKYLIEHAGKVLTHRMILQAVWGQGYLDQAQYLRVFIGQLRKKIELVPARPSFIVTDPGVGYRFCQDGDASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9I2</accession>
    <name>A0A1W1I9I2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding response regulator, CheY like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49674">
        <property type="protein sequence ID" value="SLM49674"/>
        <property type="gene ID" value="NSJP_3507"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3507"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="27"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="168" mass="18734" checksum="151FB92A3ED20415" modified="2017-06-07" version="1">MHFHGKNHVGTNGIFPAYGCSMPPTPSLLLIDDSSGERELFREALLRTELEVMLFAEQDAEAALRFLLHRASLGVPPSVVLLDWHLRRWGGQEFLRQLRAHPSIATTPVVVLSTSDSVVDVSAAYANGANAYVVKPNTFDELVRCIHTMCRFWVSCNVSPRLVEESRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9L7</accession>
    <name>A0A1W1I9L7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">ftsH</name>
        <name evidence="8" type="ORF">NSJP_3570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3570"/>
    <dbReference type="EnsemblBacteria" id="SLM49737">
        <property type="protein sequence ID" value="SLM49737"/>
        <property type="gene ID" value="NSJP_3570"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3570"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="CARD" evidence="7">
        <location>
            <begin position="549"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="194"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="603" mass="67333" checksum="94C06C94426B639B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9M0</accession>
    <name>A0A1W1I9M0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thymidylate kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3454"/>
    <dbReference type="EnsemblBacteria" id="SLM49621">
        <property type="protein sequence ID" value="SLM49621"/>
        <property type="gene ID" value="NSJP_3454"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3454"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="462" mass="52076" checksum="1E7207DCFBF2433B" modified="2017-06-07" version="1">MTTAVQVQAPMTLGSAAPAGESGKALCEILARFDRDGVEYALLHPVRYGEGEIAGDVDIGFLADPRTVVTPILRAMEAEGWLQIVHCLHYDVLHGYYYILKITDRRGLYLHLDCLCDPFGVNRYHVPIPALLDGRARISGVVRLSADKEVLYTLIKRVMKGAFAQQKVMGLQQGLVNCAKQLEGPLTEWFGVEGREKLDSLCRTEDVQSATDLLNQLRTGLESRFRRAHLLSYLGGKLLSWVRRFRRFLRPSGLFVVLIGPDGSGKSTVAGLLPIELERAFRATWRFHWRPNLFPKLSRRDTDRSAGGSEGIAPPQDAAYGRVTSCVRFLYYLMDFAVGYWLVIYPRKARTTLIVGERYFADVVVNPQRYGFALPSWLLRLGARLVPNPDVTILLVNEPDVVHARKPELSSESISEQMRQYQEELPRWGHMCAVRTDGTPEDVVLRISHVLVQECATRLRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9N2</accession>
    <name>A0A1W1I9N2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49724">
        <property type="protein sequence ID" value="SLM49724"/>
        <property type="gene ID" value="NSJP_3557"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3557"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="468" mass="52115" checksum="0CCF962B61AA0A67" modified="2017-06-07" version="1">MKHLLIALATLWILFQITSLIGLSNNPSGVTPLTRLAEPPAVHLTDPYHNAYFFLLGLASSAGLDPGKVGYEIWVEARETSDGRRFDYDKPERLDLQVSHPLGQAFPNWDTEDPIMAFRDKNAPVKAWTSQHGLLLERYEHCLDMSFEDRGFGQRATPRFAEVMLAHRLYIADGFSRSTTAGLDRLNKELTFWRMVLREATTPDMTVAAQFVVQDDAKLISRMVSRPAVDKTLLLTALQLMVPLTSSEYSLRWPIRHQLAVAGRETQGRLAPAKDSLVSSNPERDWLIATTQLPDNAFAKIEHPRPPSFLGYSLGSRQTDEMYAGYYEAITKASGTGEGSLPTLHQISGNVHRGFLESLVNPAPVEPDWNIFRHQLMETDARLRLASLQIQLRRPSGTAAVPTRLAEVGSQYFDPFTGLPMLWSQTQQKIYSVGKDRLDDGADASFDITAPALVGLSPKSSTGKDPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA07</accession>
    <name>A0A1W1IA07_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenine deaminase</fullName>
            <shortName evidence="1">ADE</shortName>
            <ecNumber evidence="1">3.5.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Adenine aminohydrolase</fullName>
            <shortName evidence="1">AAH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenine + H(+) + H2O = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3669"/>
    <dbReference type="EnsemblBacteria" id="SLM49836">
        <property type="protein sequence ID" value="SLM49836"/>
        <property type="gene ID" value="NSJP_3669"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3669"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01320">
        <property type="entry name" value="ADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01962">
        <property type="entry name" value="Adenine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028892">
        <property type="entry name" value="ADE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="PTHR43114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="A_deaminase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="370" mass="41975" checksum="B15885FF06D11535" modified="2017-06-07" version="1">MLDSAQSPLAIHHGEYMNAELLQLAQRMPKAELHLHIEGSLEPELLFRLADRNGIRLNYPDVNALRAAYAFNNLQEFLDIYYIGMSVLREEEDFYDLTWAYLERVHRDNVVHVEIFFDSQAHLDRGIPLEVQIGGIRRALRDGLAQLGISSKLILSFLRHLPEAHALETLALAQPFLDQLDGFGLDSSEIGHPPEQFARVFARCRELGFRVTAHAGEEGPAEYVRQALDLLRVDRIDHGNHSLDDAALVRRLTAEGKILTVCPLSNLKLRVVQTMDRHPILTMLERGLKATVNSDDPAYFGGYVNDNYRALIAHLPVTREDLYRLARNSFEGAWISEEAKATYLDELDRAFATDRRGARDMSRRVAGRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA50</accession>
    <name>A0A1W1IA50_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3703"/>
    <dbReference type="EnsemblBacteria" id="SLM49870">
        <property type="protein sequence ID" value="SLM49870"/>
        <property type="gene ID" value="NSJP_3703"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3703"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="39" mass="4689" checksum="07160C6B750E163E" modified="2017-06-07" version="1">MRFDNRYCWVMRFEGAVIVEVRAYLDSALVQRLIDENPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAA1</accession>
    <name>A0A1W1IAA1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49809">
        <property type="protein sequence ID" value="SLM49809"/>
        <property type="gene ID" value="NSJP_3642"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3642"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004658">
        <property type="entry name" value="OMP_Slp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03843">
        <property type="entry name" value="Slp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="174" mass="19599" checksum="032201CBDBFAEA57" modified="2017-06-07" version="1">MTMTARTSFYRWTSSLVVVVSVVVAIGCSSVPRRYIWMADTSVTLTSLSSDLPAHVGKVVLLGGTIVEEEQNEQYVFLHLKNRPLDQDYKPHRPPSLSGPEAGEYWVAVPQKQLPSNYQNWGRVTVAGRVTAERFQTEPVLLLLYMRGWDTSGKHNVWENIDPQYVPSSPLSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAM6</accession>
    <name>A0A1W1IAM6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49929">
        <property type="protein sequence ID" value="SLM49929"/>
        <property type="gene ID" value="NSJP_3762"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3762"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="98" mass="10734" checksum="C32D899C40D19995" modified="2017-06-07" version="1">MLSHPAQQPGGGTNKENASTALSQQTSLNGFIAARRVRCSSAKGSPLCFPACYHNMSRTVKCDTAFTSVRFRRNEPQQDTDLRYQLLFVQSGGLLLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAQ3</accession>
    <name>A0A1W1IAQ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3898"/>
    <dbReference type="EnsemblBacteria" id="SLM50065">
        <property type="protein sequence ID" value="SLM50065"/>
        <property type="gene ID" value="NSJP_3898"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3898"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="256" mass="29031" checksum="E45ECDB6059EA0FC" modified="2017-06-07" version="1">MQFNPGSDEKFQIVLNTYRVFGFWETLKEVILYVLSRKPADDFDRKYGVVTSGEAESSEAGITDETARSLAVAYVPSREIVIRHILHNTTKGLDLKEYSFIDLGCGKGRALIVAAQLPFKEVIGVELSPLHSEVATANIERYLSNPNCAAACRNVRVNCANALDFEFPVNDLLIYMYRPFIGPVFRGVADNLRRFQETTGRRVLIAYSCPVEELMLGQYSGFVKRTEYQVISMDYSWSLWECRREEEPALSLSRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAZ8</accession>
    <name>A0A1W1IAZ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Iron dicitrate transmembrane sensor FecR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3924"/>
    <dbReference type="EnsemblBacteria" id="SLM50091">
        <property type="protein sequence ID" value="SLM50091"/>
        <property type="gene ID" value="NSJP_3924"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3924"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032623">
        <property type="entry name" value="FecR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16220">
        <property type="entry name" value="DUF4880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4880" evidence="3">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="121"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="326" mass="36523" checksum="0163C743C9EFB19B" modified="2017-06-07" version="1">MPTTNQSSSSGEGGLRAEAIAWVIRLRNQHLSPEERQAFDAWHAQSPIHAKMYKNVSEVWDDPELHGAAIEAARTEVPSTARPRPAISRWFGYGSAVAACAILMWMAAFEFDLITKWQADFSTVVGERRMIELPDHSMVMLNTDTAIAMAFDEQGRRIRLLKGEASFKVQSDPDRPFLVESTDTTTRAVGTEFIVRAGSMSDRVTVVEGTVEVANRRTDEQTKRLSAGFQVEMQTGRLGDPRPVDLYTVAAWRRGRLVVNGAPLEQVINDVRRYHPGMILLWNRDLASTQVTGTYNLEEPSKILALLTKTFPLRSVAVTDRFIVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB26</accession>
    <name>A0A1W1IB26_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50185">
        <property type="protein sequence ID" value="SLM50185"/>
        <property type="gene ID" value="NSJP_4018"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4018"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="61" mass="6453" checksum="7A6A6AFE4F2746D4" modified="2017-06-07" version="1">MVALSLDKHMVSAALQKKSQACTPSRAGRMDSRHVSGQWPAGLSVSRIQSGGMVSEERSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB36</accession>
    <name>A0A1W1IB36_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">era</name>
        <name evidence="12" type="ORF">NSJP_4081</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4081"/>
    <dbReference type="EnsemblBacteria" id="SLM50248">
        <property type="protein sequence ID" value="SLM50248"/>
        <property type="gene ID" value="NSJP_4081"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4081"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="11">
        <location>
            <begin position="2"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="196"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="8">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="8">
        <location>
            <begin position="36"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="8">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="8">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="8">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM50248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="294" mass="33086" checksum="346D5A0798D36ACB" modified="2017-06-07" version="1">MKFGTVVIVGRSNVGKSTLLNRLLKEKIAIVSEKPQTTRTRILGVVHAPGAQVAFLDTPGIHRPEHLLNRRMVRTTLDTLEEADLFFVLMDATSLPGPGDLSVLEHVKAAIQKQARPVMLVLNKIDRVNKMKLLPVIDTYARLYPWTEVVPVSAETGANVERLLDVTVAHLPMGDAAYDEDTITDQSMRTLAAEMIREKLLRQTYEEVPHSIAVEIDQFVEEGKKARISASVLVERESHKAIIIGKHGERLKVVGTEARIEMERVFGMKVFLELWVKVREAWREDEHALSELGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBC9</accession>
    <name>A0A1W1IBC9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fructose-1,6-bisphosphatase class 1</fullName>
            <shortName evidence="7">FBPase class 1</shortName>
            <ecNumber evidence="7">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">fbp</name>
        <name evidence="11" type="ORF">NSJP_4118</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the FBPase class 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4118"/>
    <dbReference type="EnsemblBacteria" id="SLM50285">
        <property type="protein sequence ID" value="SLM50285"/>
        <property type="gene ID" value="NSJP_4118"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4118"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="PTHR11556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBPase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="FBPase_C" evidence="10">
        <location>
            <begin position="200"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="118"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="261"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM50285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="333" mass="36361" checksum="06AE21AFF8E9B2F1" modified="2017-06-07" version="1">MALHSLTLEQYFNRSHTAVPGGGPPFTTLLSHVGLVGKLLSRDLRLAGLLDVLGTSGDTNVQDEAVKKLDQIANETCVQVFQRSDVVCALASEEMEKPVIVSKPGRQAPYMVLFDPLDGSSNTDVNMPLGSIFSIVTHQPDDRPPGDRDLLQKGTDQLAAGYLLFGPSTMFVVATGKGVHGFTLDPGLGEYLLSHENMTIPTRGRIYAANEGNYQKWPEGTKRYFDHLKMDDKGTGRPYSGRYSGCLVADVHRILLNGGIYLYPAEAKKPEGKLRLLYEANPLALIVEQAGGLASTGTKRILDVQPERLHQRVPLLIGSRDDVREAEAFFAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBL4</accession>
    <name>A0A1W1IBL4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional protein PyrR</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">Pyrimidine operon regulatory protein</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">Uracil phosphoribosyltransferase</fullName>
                <shortName evidence="4">UPRTase</shortName>
                <ecNumber evidence="4">2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">pyrR</name>
        <name evidence="6" type="ORF">NSJP_3996</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3996"/>
    <dbReference type="EnsemblBacteria" id="SLM50163">
        <property type="protein sequence ID" value="SLM50163"/>
        <property type="gene ID" value="NSJP_3996"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3996"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01219">
        <property type="entry name" value="PyrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023050">
        <property type="entry name" value="PyrR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="19"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PRPP-binding" evidence="4">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM50163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="185" mass="20619" checksum="CA7249C663BB98AA" modified="2017-06-07" version="1">MSHVKNDPTQEKPVMDAGDISRAVTRIAHEILERNKGVAQLALVGIRTGGVHLGHRLVRRIHDIEGVTVPMGELDITLYRDDLALRKEQPVLRKTSVPFDISDKIIVLIDDVLFTGRTIRAAMDGLMDLGRPAEIQLAVLIDRGHRQLPIKATYVGKNIPTSREEQIQVLLEEAGEEDRVVISRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBN7</accession>
    <name>A0A1W1IBN7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_4132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4132"/>
    <dbReference type="EnsemblBacteria" id="SLM50299">
        <property type="protein sequence ID" value="SLM50299"/>
        <property type="gene ID" value="NSJP_4132"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4132"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="156"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="418" mass="46973" checksum="77AC93E1D1EA5E12" modified="2017-06-07" version="1">MQVLLRLLRAVLMTAFLLCAVDLTLVVFGSGVSLDIGGLRLHSTTMEFPVIGLLVTGLTALASAGKWREAALVCGSLVGAGVAAEAMLRVSDHPLSKAHIDYAAWYRPSDKFGHELVPGFEGFGPLNVPIRINEQGFRDGEHAPRKPADTVRILGLGDSFLFGWGVPEDRTFLRRLERLLADRTGRQIETINTGVPGWGLNQYYIYLTSMEPQLAPNLIVLAYFVDDLNGPLQDRLPPDLQYQQGLQYKGGVLHRSRLFNFMKSLSHLVREKNRPARVGYLHDLDVRREEWSKRSNYLMSTGDTEERRQYIDLLGRHLARVKERADAAQAALVLMLIPDVSQLHHPDVQQINHILLDACRRLRIPFVDMTPIFEQTNDPGRFYLWPRDPHTNEAGHAEMAGALDRLICRSGMIPQLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBQ9</accession>
    <name>A0A1W1IBQ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_4152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4152"/>
    <dbReference type="EnsemblBacteria" id="SLM50319">
        <property type="protein sequence ID" value="SLM50319"/>
        <property type="gene ID" value="NSJP_4152"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4152"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="330" mass="36882" checksum="FFAACBDC7A1D2091" modified="2017-06-07" version="1">MITTTVLDIKANCQMILRRIYRRFAGTKGTQGVHVYYANCQHSDERLREEVEFSMACGAEYAKHVAKELRRPVKPIPDLSSLSVLELGPGINLGAILFCAMAGARVAVFDKYLVDWHSDYHPRFYSLLREGLHRKYPTLDMTILDLVTSERCHPAEFIQMKRGDFVPGGIDFDDSLFDAVVSNATLEHVTDVPSLCGELGRITRPGGIGIHQVDFRDHSSNERPLEFLTIPDSTYAVSFADGHGGRGNRVRPADLIAEFEKAGLELVRFEPNCFADETYVKAIRPSLLPRYASTSLDDLRVVGGRLFVRSGKVRPHTSEERQSGRAAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I012</accession>
    <name>A0A1W1I012_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46312">
        <property type="protein sequence ID" value="SLM46312"/>
        <property type="gene ID" value="NSJP_0140"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0140"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="350" mass="37307" checksum="E9087584F90945FD" modified="2017-06-07" version="1">MLHRMVLRVLPSLSLAVTEDAVRKKKRIVMFAPGMVAFGCYRLAKHVLPLSEPWVLLVTCGALGVVTAAAAYRVGRASDWRTMGEQDGAGLLSWIAGWIGFAYGVQLSLLVLSLLWLVGYDYLQHPDGPAMMAMIISCTAVARDAFEIGHVRKMQIMGRPFTTFPNGASLRELIGSRSAPWRPWVATGLLAGALVASLGHGVQTGQLALIVQVTAVTLVGGTIALGAYFSGVRPQVPWTSGLLGTKLSESLKYWWWPGMAFASTYYLVAAGVVIFVAREPGVPTWCAAAAGGIVGALMGLYGYYLGHRRHIEDQQAPEVSTAMLRCPFVMGILGKSGAGASLAAPSTSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I073</accession>
    <name>A0A1W1I073_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_0224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0224"/>
    <dbReference type="EnsemblBacteria" id="SLM46396">
        <property type="protein sequence ID" value="SLM46396"/>
        <property type="gene ID" value="NSJP_0224"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0224"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00427">
        <property type="entry name" value="TIGR00427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="211" mass="22128" checksum="AE38A6269EEFEE9B" modified="2017-06-07" version="1">MTLTEYGVLAFSSLFVIVDPIATVPAFLAMTARDTIPQRLRMARVACLVAVGILAAFGLIGQWLFALLGITLPALQIAGALVLLLVALDMLRAQRSPVQGTEAETAEGATKDDIAVTPLAVPMLAGPAAISTVILLDAQAVDWTYRALLLTCVALVGLASYLILAISASGARWISPLAEKIITRLMGLLLAALAVQFLFNGLKGEGGLFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0A2</accession>
    <name>A0A1W1I0A2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46273">
        <property type="protein sequence ID" value="SLM46273"/>
        <property type="gene ID" value="NSJP_0101"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0101"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013048723" evidence="1">
        <location>
            <begin position="29"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="134" mass="14707" checksum="246ED8BE56227E38" modified="2017-06-07" version="1">MKRSMTKRILALYACVVLGLGVGCTAVAPNGPEEYPAQKALIGKTRQELLACAGKPVSERAGGERPAVIYYREASQLEESFPGSKSSFAKVHHGCRATIVLDQDRVADVRYESDPSSYQDEDHCEEIFDRCVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0E8</accession>
    <name>A0A1W1I0E8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46478">
        <property type="protein sequence ID" value="SLM46478"/>
        <property type="gene ID" value="NSJP_0306"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0306"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="176" mass="20135" checksum="652B895F59F1FC64" modified="2017-06-07" version="1">MSIRLAAWMKEYDMTPLPRRTAWTIVLVLLSSLWLSHCAHDTYQERADLIKDHTEAFYNHLKANRIEAAIRENEQIEAMASRMGETVRKQAAKQGTTHVEREFALMKTASETAATNWLALGQYFAIKKQYPQARATYQRIIDTYTNPTDRPYREQAARALADLDILNPPAASPVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0F6</accession>
    <name>A0A1W1I0F6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0197"/>
    <dbReference type="EnsemblBacteria" id="SLM46369">
        <property type="protein sequence ID" value="SLM46369"/>
        <property type="gene ID" value="NSJP_0197"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0197"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013094131" description="FGE-sulfatase domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="301" mass="33440" checksum="285A396B8AED40DE" modified="2017-06-07" version="1">MPSFRLVCFTVALALCTLPVSAAKHGPSAELSRHLAAIAALAVPSPTVVIPAGQFLLGSKRIDDDPYGLWTQFDDTELPQQRVWLDAYAMDRDEVSLGEYLLFLQHRKQSPSEELQKLIWHVITVHSISDHTLSRWPALYVTWYEASDWCASKGKRLPTEAEWEKSARGEDGNLFPWGSQPPDGRLAMFDQHHVHEIPILAPVDSLDSGRSPYGIHHSAGNVAEWVQDWFGFDYYAYMPERNPPGPTSGRYKSVRGGSWKSRAIMLRTATRGGAPPGNRSPTVGFRCAAAVEPPGHSPNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0G2</accession>
    <name>A0A1W1I0G2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46462">
        <property type="protein sequence ID" value="SLM46462"/>
        <property type="gene ID" value="NSJP_0290"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0290"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="164" mass="18726" checksum="A947DF80E0863B4A" modified="2017-06-07" version="1">MNPPHDEAQKNASHIVVAYGRILEDSPTSLTILFRPESDLPYPKSIIRSALELLLLTIRDAETRKSLEACDVLLNRFLPQDEYCVAYQQRAGLAQAVERFKPGVSVDITFLKPLVTEGATKEGEERLAQIVEQWKRECDRTVLRHQEIRRDVELVQKSGEKRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0G3</accession>
    <name>A0A1W1I0G3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46498">
        <property type="protein sequence ID" value="SLM46498"/>
        <property type="gene ID" value="NSJP_0326"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0326"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="53"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="163"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="222" mass="25447" checksum="D8113950B207745F" modified="2017-06-07" version="1">MMSDCFTATTVLSWSELRLPMADESLTVAQTAPEDRDLLRRIREGDTDRFAELINRHQQHVVRIVGRRVPADDVDATVHDVFVRAYFGLGQFSGSVSFDHWLAGIAVRTCYDFWRSRHRGERPVSELTDSHHRWIEQALAAASNEEFKDHARREEAAEVLHWALERLSPEHRAVLTLVHLEGRSIREAAELLDWSAVNVKVRAFRARRALRDILSKSSRGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0I0</accession>
    <name>A0A1W1I0I0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC transporter, periplasmic substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0312"/>
    <dbReference type="EnsemblBacteria" id="SLM46484">
        <property type="protein sequence ID" value="SLM46484"/>
        <property type="gene ID" value="NSJP_0312"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0312"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="43"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="337" mass="37652" checksum="500B1B0146AD5317" modified="2017-06-07" version="1">MSQKARYFKIGLFVIGAVSLAVFAVILLGAGKWFEAKTMVETYFIESVQGLEVGAPVRIHGVPVGRVESIHLAREEYDLPMNTQGKFPFKGVVVVRMSVRPSVVVRSPEEDEKTIMKIAADAGFRFRLASQGITGVLYIESEFLDPERYPPMAIAWTPKTPYIPSAPSTISELGTDLRSIARKLDQVEFEKVTKDLDAMILSVTRLVKDVQAEQLGAEAKLVMTELRATVQDARRVLDSPHVAKTLEDFHRTADDLSHTAKTVRLATEQLPDLMARVNRSVRRVDALLVGQGEKVDDVFENLRSVSEELRYLTKTIEQYPSQVLFGEPPPRSQTVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0K9</accession>
    <name>A0A1W1I0K9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0345"/>
    <dbReference type="EnsemblBacteria" id="SLM46517">
        <property type="protein sequence ID" value="SLM46517"/>
        <property type="gene ID" value="NSJP_0345"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0345"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012280518" evidence="2">
        <location>
            <begin position="23"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="265" mass="28954" checksum="5E4D4D59F8AAFAC4" modified="2017-06-07" version="1">MSYVMALVIALVNLAAVWPAYAAPMGRPQAEYSADETVQNEEGTIQQRVFVTPTKERKELLTGGGEGAVQIYRYDTKVVWQVMPSQKMYMEHPIGGGQSRGGDPSQWSYEDTAMGEETLNGVKVTKYKTIATSTDGKKFGGFSWRTREGINVKQDLLYKEGNEKKRMLTELSNLKIGAQDPGLFEIPEGFTKFDMSGMMGMGRQGMGQPMGRPDVSGTPPPNMGRGQGRPQAMPQEAPPAPEPEAPSEESAADKAGNFMKGLFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0L2</accession>
    <name>A0A1W1I0L2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46393">
        <property type="protein sequence ID" value="SLM46393"/>
        <property type="gene ID" value="NSJP_0221"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0221"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="34" mass="3527" checksum="4C8A2730716257CC" modified="2017-06-07" version="1">MSIAIGTLDGVVPAAWHALAKLIAFLGVLGYDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0V7</accession>
    <name>A0A1W1I0V7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_0442</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0442"/>
    <dbReference type="EnsemblBacteria" id="SLM46614">
        <property type="protein sequence ID" value="SLM46614"/>
        <property type="gene ID" value="NSJP_0442"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0442"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028166">
        <property type="entry name" value="UB2H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14814">
        <property type="entry name" value="UB2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UB2H" evidence="10">
        <location>
            <begin position="55"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="9">
        <location>
            <begin position="150"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="8">
        <location>
            <begin position="417"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM46614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="762" mass="83029" checksum="656045755A840389" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1C4</accession>
    <name>A0A1W1I1C4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-3-methyladenine glycosylase I</fullName>
            <ecNumber evidence="1">3.2.2.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.20" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0461"/>
    <dbReference type="EnsemblBacteria" id="SLM46633">
        <property type="protein sequence ID" value="SLM46633"/>
        <property type="gene ID" value="NSJP_0461"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0461"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="193" mass="22167" checksum="0C7E87D9D0F7064C" modified="2017-06-07" version="1">MAAPVRCEWVGEKPHLIRYHDEEWGRPVHDDRTHFEMLQLEGAQAGLSWETILLRREGYRRAFARFNPARVARFDARKRAVLLKDPRIIRNRLKIDSAVTNARAFLAVQKEFGSFDAYVWRFVGGAPKQDRRASPRKIPTSTAESDALSKDLKRRGFRFVGSTIIYAYMQAIGMVNDHAAPCFLSPRAHTHSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1H1</accession>
    <name>A0A1W1I1H1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0662"/>
    <dbReference type="EnsemblBacteria" id="SLM46834">
        <property type="protein sequence ID" value="SLM46834"/>
        <property type="gene ID" value="NSJP_0662"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0662"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16325">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004564">
        <property type="entry name" value="OM_lipoprot_carrier_LolA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19574">
        <property type="entry name" value="LolA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012370785" evidence="1">
        <location>
            <begin position="27"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="200" mass="22276" checksum="6A4C9716CAE60A40" modified="2017-06-07" version="1">MNSRIEQRIRICLLVLSLGLGGAAEADVDAPQPLDVPRLMELMAQVESRQDRFTETKTLTVLTEPMVLTGTLSYTRPDRIEKHVLTPYEEHLVVQGDQLTLTNKDGTKRVRVKSHPLIWSFVEAIRASLAGDAATLQRFYDVRIDGSRQGWTLTLRPFDEKAAARLTSIALHGKDSRLTSVEIIETGGDQSVMTIHEPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1H5</accession>
    <name>A0A1W1I1H5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0694"/>
    <dbReference type="EnsemblBacteria" id="SLM46866">
        <property type="protein sequence ID" value="SLM46866"/>
        <property type="gene ID" value="NSJP_0694"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0694"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010686">
        <property type="entry name" value="OBAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360">
        <property type="entry name" value="PTHR31360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06884">
        <property type="entry name" value="DUF1264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="174" mass="19349" checksum="3B9B860A5C0682DF" modified="2017-06-07" version="1">MVMKQRMLTVFVLAVIGSAWLLLTEAVAGEPKSPADGYDIHVIAPHVMANGEPGGPYHHYCKPVSDKVFQCLLFESTDPKAKLVGIEYFVAKDLTRKLPAIQWHRYFHDHRVEIATGRVKVLDMPDDQAAKVAEAAMETDGVIYHLWQPGLEFPDGTVSFPQSVGHKFPGHSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1H9</accession>
    <name>A0A1W1I1H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46683">
        <property type="protein sequence ID" value="SLM46683"/>
        <property type="gene ID" value="NSJP_0511"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0511"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="26" mass="2766" checksum="1AC5706BE9D4D96B" modified="2017-06-07" version="1">MAGACAVQSLLTNNQIFRSFALIAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1I2</accession>
    <name>A0A1W1I1I2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0675"/>
    <dbReference type="EnsemblBacteria" id="SLM46847">
        <property type="protein sequence ID" value="SLM46847"/>
        <property type="gene ID" value="NSJP_0675"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0675"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="3">
        <location>
            <begin position="255"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="309" mass="33327" checksum="10D1FFCA96714AAB" modified="2017-06-07" version="1">MRIVLNGGTGFIGQALCLSLVQDGHHVTVLTRNARSAAQLLGPLVTAVEWTGRDAGSWEHSLEGADAVINLAGAPIADARWTDARKTLLKDSRVLTTRLLVEAMSRRSSKPGTLISASGIGYYGASDDRVLNESAPRGRGFLADLCLAWEGEALRAMAFETRVVLLRTGMVLEQNGGALPKMLLPFRLFMGGPIKPGTQWISWIHRRDHIGMIQWALATPGLSGPLNAVAPGAVTVAQFCNLLGRVLRRPSWLPVPGLMLKILLGELGTLMTTGQRIYPAKALSDGYVFQYPTLEPALQAIFTKDQGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1K3</accession>
    <name>A0A1W1I1K3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46864">
        <property type="protein sequence ID" value="SLM46864"/>
        <property type="gene ID" value="NSJP_0692"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0692"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="69" mass="7731" checksum="90022F857956706C" modified="2017-06-07" version="1">MPMIVGTVVALVVMIVLALFTVTVLMSMLMVMRMGMAPGRPVRVRMRMLVRMIVSAFHKVPPRAESLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1L0</accession>
    <name>A0A1W1I1L0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46877">
        <property type="protein sequence ID" value="SLM46877"/>
        <property type="gene ID" value="NSJP_0705"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0705"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012009151" evidence="1">
        <location>
            <begin position="26"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="168" mass="19142" checksum="43491A789978A578" modified="2017-06-07" version="1">MKLERCGRYLALAVFSAATVMGAQAASAASTDVTGQGQPVLWLSDQKSTAWVEELMGQVLTYQTLADKQVIEGNYQPYLDQMIKVRNRYRAGDRRATYDGVNQFMTMLEVRMGGVDEHSAEALWNFCYRVTPDEYHARDRHVRAKGEAEVNKEEEFLRDMEERASLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1R2</accession>
    <name>A0A1W1I1R2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxine 5'-phosphate synthase</fullName>
            <shortName evidence="2">PNP synthase</shortName>
            <ecNumber evidence="2">2.6.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">pdxJ</name>
        <name evidence="3" type="ORF">NSJP_0752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="EC" id="2.6.99.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer; tetramer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.99.2" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0752"/>
    <dbReference type="EnsemblBacteria" id="SLM46924">
        <property type="protein sequence ID" value="SLM46924"/>
        <property type="gene ID" value="NSJP_0752"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0752"/>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033856">
        <property type="term" value="F:pyridoxine 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00003">
        <property type="entry name" value="PNPsynthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00279">
        <property type="entry name" value="PdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004569">
        <property type="entry name" value="PyrdxlP_synth_PdxJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036130">
        <property type="entry name" value="Pyridoxine-5'_phos_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30456">
        <property type="entry name" value="PTHR30456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03740">
        <property type="entry name" value="PdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63892">
        <property type="entry name" value="SSF63892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00559">
        <property type="entry name" value="pdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="1-deoxy-D-xylulose 5-phosphate binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="region of interest" description="3-amino-2-oxopropyl phosphate binding" evidence="2">
        <location>
            <begin position="213"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="237" mass="25931" checksum="895DABD92667B62C" modified="2017-06-07" version="1">MPRLGVNVDHIATLRQARGGSDPDPIAATVLVELAGADGIVVHLREDRRHIQDRDVRLLRDMIHTKLDLEIAADEEMAKIALGIRPDMVTLVPERRQELTTEGGLDAVGHKDRLHQIVDLLHNGGISVSLFIEPDLSQVKAAHKLSADFIELHTGRYANAQRAKEADAAVEAITQSAKLAYKLGLGVNAGHGLNYQNVKRLTHVPEIVEYNIGHSIMARAMLVGLDRAVKEMKALIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1W3</accession>
    <name>A0A1W1I1W3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nif-specific regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nifA</name>
        <name evidence="7" type="ORF">NSJP_0813</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0813"/>
    <dbReference type="EnsemblBacteria" id="SLM46985">
        <property type="protein sequence ID" value="SLM46985"/>
        <property type="gene ID" value="NSJP_0813"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0813"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="198"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="508" mass="56996" checksum="37A02EE897AB63BA" modified="2017-06-07" version="1">MRNDDESYRALLAVTNVLNSQRDTDSLWRAITEQIRKVLPWERAGVTLYNSDSDSFRFYAVETTLPHRELPRDAVIPKVGSAVGWVYENRTIHVRPDLRRQRLFLEDEYYVREGLGRMINSPLMVGSDCIGTLNIGSVECGDPDPTDLEFLQLVATQIAYAIGHVQAYEQIDRLRHQLARENEYLVEELKLTHNFGAMVGLSAAFRTALTQAEAVGPTGTTVLVTGETGTGKELMARAIHELSARRDKPFVRVNCAALPMGLVESELFGHERGAFTGADQRRAGRFELANGGTLFLDEIGEMPLEAQAKLLRVLEDGLVDRVGGTRPIPVDVRIVAATNSDLVSAVNEGRFRQDLYYRLHVFPIALPPLRERREDIPLLARHFLEAYRAKLKRPMLELSEESMSRLTNYSWPGNVRELQNVIERAVILAQSPVLTIEPQALVGGNAVAESTSNLIDVERRHIQHVLESVHWRIYGTYGAAAQLGMNPSTLRSRMKKLGLKRPVNFPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Z5</accession>
    <name>A0A1W1I1Z5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47028">
        <property type="protein sequence ID" value="SLM47028"/>
        <property type="gene ID" value="NSJP_0856"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0856"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="78" mass="8938" checksum="07677A4BA321FE58" modified="2017-06-07" version="1">MQPAWPCPVRLAFFGTIDPTQSDSLRLLTVHDFDGVAVEDEDNKEERLTSCRRTRQNPGRKESKPTICPVIPLRFPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I234</accession>
    <name>A0A1W1I234_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47057">
        <property type="protein sequence ID" value="SLM47057"/>
        <property type="gene ID" value="NSJP_0885"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0885"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="153" mass="16461" checksum="C63DAA6A1D78A185" modified="2017-06-07" version="1">MICLPRAVVLPLVAACFVFVWFPLPAAGDPLSVRDVLEEPGVFHLKQVVLQGTVRNVQPLDPYKLPAGTTCYGAYLFHLEDDTASIGVAVFGQCGVPIVKDPDVEDGTRIELRATIQAPSHGGYYLSFQGLQVAGEREGVVQAVADQITPLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I282</accession>
    <name>A0A1W1I282_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47105">
        <property type="protein sequence ID" value="SLM47105"/>
        <property type="gene ID" value="NSJP_0933"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0933"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="188" mass="21567" checksum="99639908BBC2637B" modified="2017-06-07" version="1">MGAEVPPRHPLRQLFGALTEKSFTEHLGWPDLNVTAYLSNLLVDFASTDQLYKVRSQHGKPLDTVVELLYESEVLYGAQSMERERDVHRHIGDFTLFMAGLFPEYLRRLKTAGLIYHKDFLVDYVKAGKRSYGIVAEMARNPGPDEPPLFRKLSENFELCVTGLGFVRSDLDRLRDPAYRHARDLLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2F0</accession>
    <name>A0A1W1I2F0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein adenylyltransferase SelO</fullName>
            <ecNumber evidence="9">2.7.7.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ydiU</name>
        <name evidence="9" type="synonym">selO</name>
        <name evidence="10" type="ORF">NSJP_0990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:58120"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:15073"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:142516"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54292"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13847"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138113"/>
            <dbReference type="EC" id="2.7.7.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:13846"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="EC" id="2.7.7.n1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.n1" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0990"/>
    <dbReference type="EnsemblBacteria" id="SLM47162">
        <property type="protein sequence ID" value="SLM47162"/>
        <property type="gene ID" value="NSJP_0990"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0990"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PTHR32057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="93"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="128"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="491" mass="55669" checksum="D2E51A0C0C5EEF96" modified="2017-06-07" version="1">MADRTLETLRFDNSYARLPDAFFAKLNPTPFNAPPRLIHGNPAAAALIDLDPEQFARPEFAGTFGGSLLAPGMDPLAMLYAGHQFGVYVPQLGDGRAILLGEAVNERGGTWELHLKGAGMTPFSRDGDGRAVLRSTIREYLCSEAMHGLGIPTTRALCLVGSDDKVYREDVETGAMLLRMAPSHVRFGTFEVFYYRKQYDRLRVLADYVVDRHYPHLRGTADAVARLFLEVVERTAALIAQWQTVGWAHGVMNTDNMSILGLTLDYGPFGFMDDYDAAFVCNHSDHNGRYAFNQQPYIGLWNLSCLAQTLLPLAPKEALKEALDRYTPIVESEFRRRMRLKLGLREERSGDDELIGGLLAMLQESHADYTRLFRELGRFDSAPGATNESLREYFLDRDRFAAWAVRYRERLRDEGDADDDRRERMDRVNPCYVLRNYLAQTAIEKAQRKDFSEIERLFDLLRDPYRERPGMEPYAAAPPNWGKHLAVSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2H6</accession>
    <name>A0A1W1I2H6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized oxidoreductase MexAM1_META1p0182</fullName>
            <ecNumber evidence="1">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1044"/>
    <dbReference type="EnsemblBacteria" id="SLM47216">
        <property type="protein sequence ID" value="SLM47216"/>
        <property type="gene ID" value="NSJP_1044"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1044"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="243" mass="25639" checksum="85D509D4A26E2CAC" modified="2017-06-07" version="1">MSVLHGKVAIVTGSSSGIGRAIAERFAHDGAIVVVNYRENGDRAKEVVAGIQAKGGKAMAVQADVGTVAEGRRLVSDTLTQFGRLDILVNNAGHFLPKTLAQTTEAEFDRIMALHAKGPYFLMQEAAHVLKEGGRIVSISTAGTHMNFYGATAHLGSKAALEQFSKGLALELAPRGITVNVVSPGITDTGVLTDHYKRMGTELSPFKRLGTPKDVADVVAFLVSEEAGWLTGQNIHADGGLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2H7</accession>
    <name>A0A1W1I2H7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">smpB</name>
        <name evidence="5" type="ORF">NSJP_1009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1009"/>
    <dbReference type="EnsemblBacteria" id="SLM47181">
        <property type="protein sequence ID" value="SLM47181"/>
        <property type="gene ID" value="NSJP_1009"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1009"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="155" mass="17898" checksum="CA13940B556DA930" modified="2017-06-07" version="1">MGQQDTERAVATNRKAFHNYFIEERFEAGIQLQGTEVKSLREGKVNLLDSYASVKDGEIFLHHCHISPYSHGNIMNHDPVRVRKLLLHRKEINKLLGKTQQKGLTLVPLRIYFTKRGFAKVELGLAKGKKLHDRRDSLKAREAGREVERAIKERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2J3</accession>
    <name>A0A1W1I2J3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-3-methyladenine glycosylase</fullName>
            <ecNumber evidence="2">3.2.2.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">alkA</name>
        <name evidence="2" type="ORF">NSJP_1042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.21" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1042"/>
    <dbReference type="EnsemblBacteria" id="SLM47214">
        <property type="protein sequence ID" value="SLM47214"/>
        <property type="gene ID" value="NSJP_1042"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1042"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052822">
        <property type="term" value="F:DNA-3-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052821">
        <property type="term" value="F:DNA-7-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="46"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="209" mass="23796" checksum="3D973B6F2BEC805C" modified="2017-06-07" version="1">MRLSPAIRHLSLADPVLGRLIRDVGPCKLIIRQRRSPFESLTRAIAYQQLHARAAESILRRFRALFPGRRFPRPDQVLAIDAEHLTAAGFSRAKVAALRDLADKVLDGTVPSGRLITRLEDEVIVERLIEIRGIGRWTAQMLLIFQLGRQDVLPVDDFGVRSGFKILYDLGSLPTPAEVLRFGERWKPYRTAASWYLWRAAERANFTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2L6</accession>
    <name>A0A1W1I2L6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47237">
        <property type="protein sequence ID" value="SLM47237"/>
        <property type="gene ID" value="NSJP_1065"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1065"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="462" mass="52002" checksum="8A6B3071AE6CB0D4" modified="2017-06-07" version="1">MGMDPVVTQVNEAIVGISFALDPSLEGLLARLDSLSRQPNFAVQRRLALELFLRPYLEPTSPFLQPLAQEEALALLMLYADFYPEDGQLTLVEQLRDIVTEHIPEEERRWLDPLKHSSMDLLEVLPESSAQMPLSLRSLGDDRRMKVQGDLSGRTLRPGDILLTRVIEEQGTSDRNVHLAGGALLLPMKQARSLLEASREWERSVEIVSGSFTLGEWQEFVKRYGYVLLWNAASLRLTALLEAVARIRYRTPSGTSYLYALALYDHHAYRAIAEGLSAMTELHEDARGPWLHGSDHLPSPAPVRIWVQRENEQECEGLAVRLTLTPLQLFVECDSPDRLNSVKHRLASAFGYSMRFRGESLTTPERRIPPDQLAKESPCSIVVTDEEQLALLSRFLDMAYLEWADQPSAALGGQTPRHAAAQPTLRRRVADLIDGFERHDPGMRLLGITAFNYGILRNHVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Q5</accession>
    <name>A0A1W1I2Q5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0931"/>
    <dbReference type="EnsemblBacteria" id="SLM47103">
        <property type="protein sequence ID" value="SLM47103"/>
        <property type="gene ID" value="NSJP_0931"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0931"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="145" mass="16784" checksum="9DFD387C9551A00E" modified="2017-06-07" version="1">MNEVLFHLAFPIHDRLAAKRFYVDGLGCTLGRESERAVTFGLAGHQLVAHLVDEPQAQRGIYPRHFGLVFLTKAQWQEFADRARSKGLAFYQQPRVRFPGTRIEHHTYFLQDPSDNLLEFKYYTHESAIFGERDVPEVGDSHEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2V6</accession>
    <name>A0A1W1I2V6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase 15-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1165"/>
    <dbReference type="EnsemblBacteria" id="SLM47337">
        <property type="protein sequence ID" value="SLM47337"/>
        <property type="gene ID" value="NSJP_1165"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1165"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="222"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="603" mass="66986" checksum="8F9C83DA36F6E599" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3F4</accession>
    <name>A0A1W1I3F4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein YrdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yrdA</name>
        <name evidence="1" type="ORF">NSJP_1354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1354"/>
    <dbReference type="EnsemblBacteria" id="SLM47526">
        <property type="protein sequence ID" value="SLM47526"/>
        <property type="gene ID" value="NSJP_1354"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1354"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="179" mass="19321" checksum="4943D47E027134EB" modified="2017-06-07" version="1">MLRTFQGIAPTVPASCYIEDTGIVIGDVVMGENCSVWFHAVIRGDVHFIRIGHRTNVQDLSMLHVTHDTHPLTIGDDVTIGHSVVLHGCTIRDRVLVGMGSIVMDGAQIGEDCIIGAGSLITEGTVVPPKSLILGSPAKVKRPVTEKELGWIRESAQNYVRYARLYMGGASASPPGFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3H2</accession>
    <name>A0A1W1I3H2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47525">
        <property type="protein sequence ID" value="SLM47525"/>
        <property type="gene ID" value="NSJP_1353"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1353"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="241" mass="27303" checksum="295F1BC3E4E6970C" modified="2017-06-07" version="1">MTRRLVIRSSTSAAVRRVFDRLEYRTLGSVYCYEGGDEFWRARREPCRRLGLRVARNLIGHLPRSGRSLYVGAGVAELPALVTEVLERGRAVMAHNLRRAEVAVLNRACRGTGVRFNATDAATAGGFYDHIWIVSVLNDPERFPHLAPLSYGRADPVSFDPVEFARERRIVRSIVDRCLPKLRLPGVVTTSAEEVVWIADWCHRHRIPYLVGRRQYPTALVGDPICIMRIGARRKRIRAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3L3</accession>
    <name>A0A1W1I3L3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="9">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">atpA</name>
        <name evidence="13" type="ORF">NSJP_1418</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1418"/>
    <dbReference type="EnsemblBacteria" id="SLM47590">
        <property type="protein sequence ID" value="SLM47590"/>
        <property type="gene ID" value="NSJP_1418"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1418"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="12">
        <location>
            <begin position="25"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="10">
        <location>
            <begin position="149"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_C" evidence="11">
        <location>
            <begin position="371"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="169"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="9">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM47590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="505" mass="54499" checksum="D4524D2982EE4D04" modified="2017-06-07" version="1">MQIKADEISAIIKEKIKGFDKQVDVKETGSVIQVGDGIAKVYGLDGAMAGEMLEFPGGLYGIALNLEEDNVGAVLMGDDVGIKEGDPVKRTGRIAEIPVGEALIGRVVNAIGQPIDGKGPITSQHSSRIEVVAPGVNTRQSVREPLQTGIKAIDAMIPIGRGQRELIIGDRQTGKTAIAVDTIINQKGLGVFCIYVAIGQKRSTVARVVKTLEENHAMEYSMVVSATASDAAPMQFLAPFAGAAIGEYFRDNGKHALIVYDDLSKHAVAYRQLSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDKLGGGSLTALPIIETQAGDVSAYIPTNVISITDGQIYLGSDLFYSGIRPAINVGLSVSRVGGSAQIKTMKQVAGTLRLDLAQYREMAAFSQFGSELDKATQMQLARGVRMVELLKQGQYKPMPVSDQVLSIYAGVNGFLDDVPVDKVQQFEADFLHYVQQHHAELKKEIVSIGKIDDKVGGRLKEILTTFKQKMGYGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3M9</accession>
    <name>A0A1W1I3M9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47608">
        <property type="protein sequence ID" value="SLM47608"/>
        <property type="gene ID" value="NSJP_1436"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1436"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012800036" evidence="1">
        <location>
            <begin position="22"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="109" mass="12037" checksum="33C232E8A9679CA5" modified="2017-06-07" version="1">MWSRRVFLQGLALLMLGLAGCAEPFTVFHSQTGEPILIGRRSFSYEGCLSTMQEEADRLGVTFRYIHVRGSKFGRALLWPFEPGYACEGAVGPEQPPTGAYPYPPLPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3U4</accession>
    <name>A0A1W1I3U4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">16S rRNA (cytosine(967)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">16S rRNA m5C967 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">rRNA (cytosine-C(5)-)-methyltransferase RsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">rsmB</name>
        <name evidence="14" type="ORF">NSJP_1449</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(967) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42748"/>
            <dbReference type="Rhea" id="RHEA-COMP:10219"/>
            <dbReference type="Rhea" id="RHEA-COMP:10220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.176"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.176" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1449"/>
    <dbReference type="EnsemblBacteria" id="SLM47621">
        <property type="protein sequence ID" value="SLM47621"/>
        <property type="gene ID" value="NSJP_1449"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1449"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004573">
        <property type="entry name" value="rRNA_ssu_MeTfrase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00563">
        <property type="entry name" value="rsmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="13">
        <location>
            <begin position="183"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="273"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM47621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="474" mass="52081" checksum="CC69C5B66EC59412" modified="2017-06-07" version="1">MGTETRPSVRKPSARSIALAVLVESVQSADPIDGLLERACAPISHDPRERALAVELVYGVLRHQGTIDWRLQPVLDKPMRKLPRLIQMLLRMAAHQLLSLDRIPHSAAVNESVQLAKINVPVLGRDWSGFVNAVLRALLRNPEPSWPSAKDDSIRSLSVRYSVPEWLTCRWVDRLGADEAEAACAHSVTVPPVTLRVNRLKATRDDFLERLRQSGISASPTRVSPVGITIEPRGPITSLPGFSEGCFYVEDEAAQLIPPLLGVNSGEAILDACAAPGGKATHIAELIGDRGTILAVDKKGARLDLVAANCTRLGLRSVVAITGDARYRDEWQRTATHSHDPSEVRKTLVDRVLVDAPCSGLGVLRRHPEAKWRKDGAALARHQKLQLEILDALSASLRPGGVLVYSTCSVEPEETHAVIERFLNAHADFRRESLAPWLPNEAQNLLTGHGDLTTENNRYGMDVFYASRLRKRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3X6</accession>
    <name>A0A1W1I3X6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NSJP_1397</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1397"/>
    <dbReference type="EnsemblBacteria" id="SLM47569">
        <property type="protein sequence ID" value="SLM47569"/>
        <property type="gene ID" value="NSJP_1397"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1397"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="12">
        <location>
            <begin position="59"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="10">
        <location>
            <begin position="278"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="11">
        <location>
            <begin position="571"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM47569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="901" mass="100077" checksum="3B18D95E7F15B909" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I434</accession>
    <name>A0A1W1I434_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsmG</name>
        <name evidence="3" type="ORF">NSJP_1411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1411"/>
    <dbReference type="EnsemblBacteria" id="SLM47583">
        <property type="protein sequence ID" value="SLM47583"/>
        <property type="gene ID" value="NSJP_1411"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1411"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="136"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="228" mass="25178" checksum="8A995243A97DB506" modified="2017-06-07" version="1">MFHVEHEGDLERFLIHSAEKMGIALTGIQSAQFMRYLSQLLHWNRTINLTSISNPREIVIKHFIDSLIPISTIPFPHQAQLVDVGTGAGFPGIPLKIVRSDLRVKLIEPNKKKCSFLSALIGTLKLADVEVFSGTIQEYAARSDASAQVITARALRLDEMQPELVSLALPAGKIVLYRTEPLALPDLPAELAIETQQKFELPEDAGERVITVLSAENKPGCSTWNSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I444</accession>
    <name>A0A1W1I444_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">atpC</name>
        <name evidence="9" type="ORF">NSJP_1421</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1421"/>
    <dbReference type="EnsemblBacteria" id="SLM47593">
        <property type="protein sequence ID" value="SLM47593"/>
        <property type="gene ID" value="NSJP_1421"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1421"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020547">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00401">
        <property type="entry name" value="ATP-synt_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_DE" evidence="7">
        <location>
            <begin position="87"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="141" mass="15603" checksum="9FA53A2ACA5CE820" modified="2017-06-07" version="1">MAGKILLEVVTPEKLLLSQQVDEVIAPGSEGEFGVLPGHCHFLSTLRIGELRYRVGERTLHMAVLWGYAEVTPDRVTIMAEIAEKAEDIDVGRAQAAVESAERRLKAGGLPSELKEAEISLEKSRLRKKLAERHQNRPSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4C1</accession>
    <name>A0A1W1I4C1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NSJP_1619</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1619"/>
    <dbReference type="EnsemblBacteria" id="SLM47791">
        <property type="protein sequence ID" value="SLM47791"/>
        <property type="gene ID" value="NSJP_1619"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1619"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="264"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="327"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM47791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="383" mass="40876" checksum="C042000CFD2CFF6A" modified="2017-06-07" version="1">MSMPAIEIGRALGIPIRVHMSWFLVFMFVSWTLATGYLPEALPGLSGQRYWGMGAAAALLLFLSVLLHELGHSYVAQRYQIPIGQITLFIFGGVAHMGKEPPSPRAEFLIAIAGPVVSLVLGLLCLGGTILAESVLHLSGTQGFVVLGGLLGIVNVNLGLFNLIPGFPLDGGRVLRAGLWAWGKNFHRATGQAATVGFLFGIVLAGFGALVVGGTVAGALDPSLAGNGGWLLFIGAFLGGAAWSARRQVGLRIVLDTTMVRDVMIRNVVSVSPTLSVQGAVDDFFVAYGFSGFPVTEDDRIVGIVTTDDVQAVPQGLWAWKTVLDIMRPSTEALFIPADWSVRLALDRMIQEGWDRLIVTEDGKPVGLITRSSVARFLQLRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4C9</accession>
    <name>A0A1W1I4C9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="4 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">nrdA</name>
        <name evidence="15" type="ORF">NSJP_1688</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 12"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1688"/>
    <dbReference type="EnsemblBacteria" id="SLM47860">
        <property type="protein sequence ID" value="SLM47860"/>
        <property type="gene ID" value="NSJP_1688"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1688"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="14">
        <location>
            <begin position="34"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SLM47860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="813" mass="90558" checksum="FF728C0249FB964D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4G6</accession>
    <name>A0A1W1I4G6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ECF family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47831">
        <property type="protein sequence ID" value="SLM47831"/>
        <property type="gene ID" value="NSJP_1659"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1659"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="113"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="186" mass="21318" checksum="29FBEDE14ADC697C" modified="2017-06-07" version="1">MDSKARSHSVMERLIEHEPAFRAFLRRRVGNEAVADDILQQSLTRAVERHHAVRKEESVVAWFYRILRHALIDYYRSRKAEARRNGAFLRELIASGDEQEPPLDEVEAAVCACLHRLLPDLREQYAEVVRRIDLEGESPAHLAKELKISRNNLTVRLHRARQALRASLEESCGLCSKHGCLNCVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4M5</accession>
    <name>A0A1W1I4M5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADPH-dependent 7-cyano-7-deazaguanine reductase</fullName>
            <ecNumber evidence="1">1.7.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-carbaguanine reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NADPH-dependent nitrile oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PreQ(0) reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">queF</name>
        <name evidence="2" type="ORF">NSJP_1784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH</text>
            <dbReference type="Rhea" id="RHEA:13409"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="EC" id="1.7.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.13" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1784"/>
    <dbReference type="EnsemblBacteria" id="SLM47956">
        <property type="protein sequence ID" value="SLM47956"/>
        <property type="gene ID" value="NSJP_1784"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1784"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046857">
        <property type="term" value="F:oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033739">
        <property type="term" value="F:preQ1 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00818">
        <property type="entry name" value="QueF_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029500">
        <property type="entry name" value="QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016856">
        <property type="entry name" value="QueF_type1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14489">
        <property type="entry name" value="QueF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027377">
        <property type="entry name" value="Nitrile_oxidored_QueF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03139">
        <property type="entry name" value="QueF-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="72"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="91"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimide intermediate" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="132" mass="14989" checksum="5398DB542DF3C955" modified="2017-06-07" version="1">MTRRSKTKLGYNDRHAKSGITAPLPDIETFPNQYKGYEITIEIPEYTAICPKTGLPDFGTITIHYMPDKDCLELKSLKMYIHAYRNLGIFYENSVNRVLQDVVTACRPVWAKVTGTFAARGGLRSVIEARYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Y5</accession>
    <name>A0A1W1I4Y5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47949">
        <property type="protein sequence ID" value="SLM47949"/>
        <property type="gene ID" value="NSJP_1777"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1777"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="232" mass="26182" checksum="06ECB4D132A6B592" modified="2017-06-07" version="1">MSQCLYCKQRKGKRSCPALGGLICPLCCGEHRIVRIACPQDCDYLESGSDYQQKRLGEHFMPLRREFYRQLADFGGEKAVALYNLVEVVTFSYFQDRRDGQDAEIITAIQALRRTLSPLHVPSAPMPIFAEHLKKEYDSFKKQNPQQIADATLAPEVLDRSIRFVSEFSGAGFQSQRFLAGLVGYVRAYHPEIAAHLTKQHEAGRIVLPNQSFAPPSPEPHVHGPGCEHHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Z8</accession>
    <name>A0A1W1I4Z8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48070">
        <property type="protein sequence ID" value="SLM48070"/>
        <property type="gene ID" value="NSJP_1898"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1898"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="122" mass="13811" checksum="7B243B4861A00BF6" modified="2017-06-07" version="1">MRSPPHPISEHSLTAERTFNCGKDPAEFSARKTWPNTTTTVSKKSETVQVLRSKYENTRGAVSIDTGFSQHKHVTPYDLQLPVWHPSLACKAAMEPLHFSIEYGACPNHMQMITEALEWEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I520</accession>
    <name>A0A1W1I520_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48117">
        <property type="protein sequence ID" value="SLM48117"/>
        <property type="gene ID" value="NSJP_1945"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1945"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010747228" evidence="2">
        <location>
            <begin position="29"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="116" mass="10805" checksum="659D4D52A67C9889" modified="2017-06-07" version="1">MKLKKTIMVTLAVVGVGLNTGMASMAEAADTGGMSQSDKSQQPGLPDPGAKQRTPSADPTDRRNTDPNMGRTPTGTPGGTGPTAPGSGSGMGSSGGGSSSGGAGGSGGAAGGGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I530</accession>
    <name>A0A1W1I530_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative maltose O-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.79" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1934"/>
    <dbReference type="EnsemblBacteria" id="SLM48106">
        <property type="protein sequence ID" value="SLM48106"/>
        <property type="gene ID" value="NSJP_1934"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1934"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008925">
        <property type="term" value="F:maltose O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="2">
        <location>
            <begin position="5"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="54" mass="6122" checksum="F6C5C143E2B837F6" modified="2017-06-07" version="1">MMAGRQKMLAGELYYPMDEELIRARERARHLCQTLNTSLGSINGQQRSTLIGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I539</accession>
    <name>A0A1W1I539_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis response regulator protein-glutamate methylesterase</fullName>
            <ecNumber evidence="3">3.1.1.61</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.61" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1940"/>
    <dbReference type="EnsemblBacteria" id="SLM48112">
        <property type="protein sequence ID" value="SLM48112"/>
        <property type="gene ID" value="NSJP_1940"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1940"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheB-type methylesterase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="200" mass="21143" checksum="F5658EFA7B261444" modified="2017-06-07" version="1">MTDQASSRRNVIVIGASLGGVNALQYLCANLPSDLPATVGVVIHRSPWWVSNIPAIYGRTPGGIRVQEAQAHDVLKEGVVYFAPADHHMQFGKGVIQLTRGPKLHFTRPAADALFISAAKTFGDRVIGVVLTGGGADGAHGLIAIKASGGVSVVQDPKEAVDPSMPVNGIRMDSVDHVTPLAELPKLLWCLTTEVAEKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I547</accession>
    <name>A0A1W1I547_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="5">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">panB</name>
        <name evidence="9" type="ORF">NSJP_1781</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1781"/>
    <dbReference type="EnsemblBacteria" id="SLM47953">
        <property type="protein sequence ID" value="SLM47953"/>
        <property type="gene ID" value="NSJP_1781"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1781"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="5 7">
        <location>
            <begin position="42"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7 8">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="262" mass="28200" checksum="0AEE2C0091CDECEE" modified="2017-06-07" version="1">MMKVPDLRRYKHGKRLIVVTAYDALFARIIEQAGIETILVGDSLGVVVQGKANTLSVSMDEMLYHTKLVAGAAQQALVVGDMPFMSYQASREDALRNAGRFLQVGAHAVKLEGGSAVVDRVHDMTQTGIPVVGHLGMTPQSVNQYGGYKVQGKEAAQAETMVQDAKALEAAGAVAIVLEAMPADLAKSITDTLAIPTIGIGAGPHCDGQVLVLYDLLGLFDDFVPKFVKPYAHLKADALQALRRYKEEVEQGKFPSDSESYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I580</accession>
    <name>A0A1W1I580_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48081">
        <property type="protein sequence ID" value="SLM48081"/>
        <property type="gene ID" value="NSJP_1909"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1909"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007367">
        <property type="entry name" value="DUF433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04255">
        <property type="entry name" value="DUF433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="103" mass="11412" checksum="A4E770242B9703B3" modified="2017-06-07" version="1">MTTKTLDQHIETSLDIAGGKPRIAGHRITVRDIVIWHERLGKSVDEIASDYGLTLADVHAALAYYFDHRADIDKDMADGQAFAESLRQATPSKLKHKLNAGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I582</accession>
    <name>A0A1W1I582_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="5">IGPD</shortName>
            <ecNumber evidence="5 6">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">hisB</name>
        <name evidence="7" type="ORF">NSJP_2006</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5 6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2006"/>
    <dbReference type="EnsemblBacteria" id="SLM48178">
        <property type="protein sequence ID" value="SLM48178"/>
        <property type="gene ID" value="NSJP_2006"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2006"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="202" mass="22303" checksum="47360C04ED976187" modified="2017-06-07" version="1">MKKNGGPSRQASIHRATKETDIRVEWTLDGSGQGTIDTSIRFFDHMLELLARHGFFDLTVKAKGDIDIDEHHTVEDVGIVMGKALHQALGEKGGIKRFGFASAPLDETLAQVTVDLSGRPFLVYNVNLPDRKIKSFDLGLFEDFFQAFVTHGGLNLHVNLLYGRNPHHIMEAIFKGLAKALDQATTVEERLAGHVLSTKGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5B4</accession>
    <name>A0A1W1I5B4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bacterioferritin</fullName>
            <ecNumber evidence="2">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bfr</name>
        <name evidence="5" type="ORF">NSJP_2035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterioferritin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48207">
        <property type="protein sequence ID" value="SLM48207"/>
        <property type="gene ID" value="NSJP_2035"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2035"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00907">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002024">
        <property type="entry name" value="Bacterioferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002560">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00601">
        <property type="entry name" value="BACFERRITIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00754">
        <property type="entry name" value="bfr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0409">Iron storage</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="4">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR002560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR002560-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="158" mass="18179" checksum="9B13645B9541189F" modified="2017-06-07" version="1">MKAKDGVINLLNKILTADLTAINQYFVHAKMCSNWGYERLHHKVRERSIDEMKDADELIGHILYLEGVPNVQRMNTVRVGETVPEQLKLDLKAEQEMLSLLSEGVVHCTKVADFTTRHMLEDMAKDVDAHIDWIETQMETIEQIGVENYLAEQIKKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5J8</accession>
    <name>A0A1W1I5J8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">rsfS</name>
        <name evidence="4" type="ORF">NSJP_2104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2104"/>
    <dbReference type="EnsemblBacteria" id="SLM48276">
        <property type="protein sequence ID" value="SLM48276"/>
        <property type="gene ID" value="NSJP_2104"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2104"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="123" mass="13555" checksum="CF305C2AD5D1DC2E" modified="2017-06-07" version="1">MYDKKATDVVVLHVATLTSVADYLVLASADSDRQTRAIADHVDGVLSQTGSNPLSIEGKASSQWVLMDYGDVVVHIFRHDSRQNYGLERLWADAKRIPVKEEQPVPAAAKPARSKRVANSRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5K4</accession>
    <name>A0A1W1I5K4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="10">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">ileS</name>
        <name evidence="15" type="ORF">NSJP_2083</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2083"/>
    <dbReference type="EnsemblBacteria" id="SLM48255">
        <property type="protein sequence ID" value="SLM48255"/>
        <property type="gene ID" value="NSJP_2083"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2083"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02002">
        <property type="entry name" value="Ile_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023585">
        <property type="entry name" value="Ile-tRNA-ligase_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="27"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="14">
        <location>
            <begin position="697"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="zf-FPG_IleRS" evidence="13">
        <location>
            <begin position="918"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="10">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="10">
        <location>
            <begin position="614"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>L-isoleucyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:178002"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="617"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="921"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="924"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="941"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="944"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SLM48255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="949" mass="107699" checksum="F34ADBE900454A3A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5L1</accession>
    <name>A0A1W1I5L1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polyketide_cyc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2122"/>
    <dbReference type="EnsemblBacteria" id="SLM48294">
        <property type="protein sequence ID" value="SLM48294"/>
        <property type="gene ID" value="NSJP_2122"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2122"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="2">
        <location>
            <begin position="34"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="172" mass="19072" checksum="D9BCB5F402C83154" modified="2017-06-07" version="1">MAVPSAAASTDSDELQVRTEPGGGVRATAKVVFDAKPGVVFAVLTDYAHWPELFEVRMTLADLKVQDGIARIDLRIEHALLPGERRLVTDSRAATDRSIVTDLVEGDFKRYHRVWTLHAADGGVRTLAEFELLVAIDSMVPDWLVAIAMRRELESHFRIVKKKVLEPVGAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5N0</accession>
    <name>A0A1W1I5N0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48327">
        <property type="protein sequence ID" value="SLM48327"/>
        <property type="gene ID" value="NSJP_2155"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2155"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009783">
        <property type="entry name" value="DUF1348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757">
        <property type="entry name" value="PTHR31757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07080">
        <property type="entry name" value="DUF1348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="156" mass="18678" checksum="2D3BD4B61ACD0E73" modified="2017-06-07" version="1">MEAPRPPLPPFDEHTAAQKVRAAEDAWNTRDPHRVSLAYTPDSVWRNRAEFFSGREAIVEFLTRKWNKELDYRLIKELWAFRDNRIAVRFAYEWHDDTGQWYRSYGNENWEFDEQGFMRRRIASINDLPIGEKDRKYHWTPGRRPDGHPSLSDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5N2</accession>
    <name>A0A1W1I5N2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tpiA</name>
        <name evidence="5" type="ORF">NSJP_2113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2113"/>
    <dbReference type="EnsemblBacteria" id="SLM48285">
        <property type="protein sequence ID" value="SLM48285"/>
        <property type="gene ID" value="NSJP_2113"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2113"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="235"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="257" mass="27813" checksum="B9C2266977C13DCC" modified="2017-06-07" version="1">MRTPLIVGNWKMNKTASEGRAFVRDFQQLVEPSTDVEVVLAPPFTALESVRSSLGATSRIMLGAQNLHWEQQGAFTGEISGSMLLDLGCRYVIVGHSERRTLFWERNEDVQKKVRAALACGLRPILCVGESLTERETGQTERIIDEQLSAGLDQLTDANLKTVTIAYEPVWAIGTGRAATTVQAGDVHRSIRAFVANRWKDAAAATMRILYGGSVTAQNAASFLESPDIDGALVGGACLNPDSFAKIIAAANRNPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5W5</accession>
    <name>A0A1W1I5W5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maltokinase</fullName>
            <ecNumber evidence="3">2.7.1.175</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Maltose-1-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_2230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-maltose = ADP + alpha-maltose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.175"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.175" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2230"/>
    <dbReference type="EnsemblBacteria" id="SLM48402">
        <property type="protein sequence ID" value="SLM48402"/>
        <property type="gene ID" value="NSJP_2230"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2230"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040999">
        <property type="entry name" value="Mak_N_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012811">
        <property type="entry name" value="TreS_maltokin_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18085">
        <property type="entry name" value="Mak_N_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02457">
        <property type="entry name" value="TreS_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mak_N_cap" evidence="6">
        <location>
            <begin position="29"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="544" mass="61323" checksum="E684B56E9C9EBF22" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Z3</accession>
    <name>A0A1W1I5Z3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endonuclease MutS2</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mutS</name>
        <name evidence="7" type="synonym">mutS2</name>
        <name evidence="11" type="ORF">NSJP_2117</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2117"/>
    <dbReference type="EnsemblBacteria" id="SLM48289">
        <property type="protein sequence ID" value="SLM48289"/>
        <property type="gene ID" value="NSJP_2117"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2117"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00092">
        <property type="entry name" value="MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005747">
        <property type="entry name" value="MutS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF14">
        <property type="entry name" value="PTHR11361:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005814">
        <property type="entry name" value="MutS_YshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="10">
        <location>
            <begin position="733"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="702"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="549"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="343"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="809" mass="87611" checksum="554744263DA3CD93" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I618</accession>
    <name>A0A1W1I618_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48468">
        <property type="protein sequence ID" value="SLM48468"/>
        <property type="gene ID" value="NSJP_2296"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2296"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010714313" evidence="1">
        <location>
            <begin position="25"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="241" mass="26959" checksum="DEE0CFC767608484" modified="2017-06-07" version="1">MVNSHKPTLGVLVLLLLTPLTNFAAEAAPEKTEVTGEYRYTFHDPETPSDALTLACREAWRLAVTESAPYRDQTANVVDSVLLREVANNLVTKYVKDQQILEQFQQGKTVTCRVRGTLVVDESVKAIRTQLAGEPSGADNLDQNRSLKILAVRDEANGTISIEYQALRRLDWLNTNYQGGLRETADIMVDFYDDQKFLIRTERYPARRSVSGDDVMNPGATGVLKVAKPLAAKTYRVWLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6K7</accession>
    <name>A0A1W1I6K7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpsJ</name>
        <name evidence="6" type="ORF">NSJP_2337</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2337"/>
    <dbReference type="EnsemblBacteria" id="SLM48509">
        <property type="protein sequence ID" value="SLM48509"/>
        <property type="gene ID" value="NSJP_2337"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2337"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="9"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="104" mass="12013" checksum="90AC44C3236F2E5B" modified="2017-06-07" version="1">MVKVDQRIRIRLRGFDYRVLDQSVAEIVETVRRSGAKIVGPIPLPTRIEKFTVQRATHADKKAREQFEIRTHKRLMDIMEPTPETMDSLMKLNLAAGVDVEIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6P3</accession>
    <name>A0A1W1I6P3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48682">
        <property type="protein sequence ID" value="SLM48682"/>
        <property type="gene ID" value="NSJP_2510"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2510"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="150" mass="17408" checksum="258B20D4ECB4E37B" modified="2017-06-07" version="1">MDNPEASDGCRSEADIARWGLPYSSKSSGTSQAGDRLEWMSLSSGILRVTRRKRESSRSFARSLIASTIVLYDNAYSEVQYFSEAHAVFTSNHTQGRGMGRPCRHDRRLRRHRRHFRPHVRSPAARDHLFHSQRQILRRQLRRFRGLDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6S4</accession>
    <name>A0A1W1I6S4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48712">
        <property type="protein sequence ID" value="SLM48712"/>
        <property type="gene ID" value="NSJP_2545"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2545"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013117015" evidence="1">
        <location>
            <begin position="29"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="155" mass="16795" checksum="5EA030FDF85DD5A0" modified="2017-06-07" version="1">MAIWKPRRWASALVYSVALAAMDSTIHAAPPTIDPCTFVTPAEVEQVIGKLKGAPTSETLGDGVRCSYNFADENNELEIWASGGAWSKLLHKDAKQPVMVKGLGDEAFMDRGKNDPEAVDLYIKKGAILIVLMTRKGPGDEEKLKTLGKKAVGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I711</accession>
    <name>A0A1W1I711_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2598"/>
    <dbReference type="EnsemblBacteria" id="SLM48765">
        <property type="protein sequence ID" value="SLM48765"/>
        <property type="gene ID" value="NSJP_2598"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2598"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="325" mass="35401" checksum="B7D8C5BD876AFEEA" modified="2017-06-07" version="1">MGGLIAATPDQTSAILGAMRDVATASGRFPLSAATVRSLRSAERHVLGGKGNVDPALLVPVKPETLAAALADAALAEMTLRCLSVSALVDGELSRPRIEAVLEYAERLGVRQDYVTELSKSVDGDLQWALTDMSRQNVLSLWNEPWDECLDINDIFMPYRSPHGDPSLAARYHALGESAEGTLGRAFSEIYRKNGYAYPGEERAVNVRFATPHDATHVLSGYDTSPRGEILVSTFTAGMHPVRPMEGHILPVLYSWHLNIKINDLAGAAKGQLDPEAFWEAWARGARTTVDLFAPSWDFWSVVHEPVAEIRRQYGIPAPLAAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I722</accession>
    <name>A0A1W1I722_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Beta-phosphoglucomutase</fullName>
            <ecNumber evidence="1">5.4.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.2.6" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2633"/>
    <dbReference type="EnsemblBacteria" id="SLM48800">
        <property type="protein sequence ID" value="SLM48800"/>
        <property type="gene ID" value="NSJP_2633"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2633"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008801">
        <property type="term" value="F:beta-phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="230" mass="25409" checksum="1CAD00DBE4B4F60C" modified="2017-06-07" version="1">MTQLRALIFDFDGVIADTEPLHFAGLQKTLREIGIDLTESDYFANYLGYDDRGCFLAALTAHARPIDPTTLRQLMERKAAAYLESVKDHSVIFPGVAELVREAAGRHPLAIASGALRHEIEYILEQAGLRKEFSHVTSAEDVTRGKPDPQPFLLAMEALRRLRDPALTPNSCLVIEDSLPGIRGAKAAGMKVLAVANTHSFQDLHEADAMTSNLKQVNLSELHARLWPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I767</accession>
    <name>A0A1W1I767_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_2658</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acyl transferase is part of the fatty acid reductase system required for aldehyde biosynthesis; it produces fatty acids for the luminescent reaction.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2658"/>
    <dbReference type="EnsemblBacteria" id="SLM48825">
        <property type="protein sequence ID" value="SLM48825"/>
        <property type="gene ID" value="NSJP_2658"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2658"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008218">
        <property type="term" value="P:bioluminescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003157">
        <property type="entry name" value="LuxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02273">
        <property type="entry name" value="Acyl_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0455">Luminescence</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="140"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="528"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="529"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1397" mass="153039" checksum="D7E97061F1F5EAD9" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7A3</accession>
    <name>A0A1W1I7A3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48801">
        <property type="protein sequence ID" value="SLM48801"/>
        <property type="gene ID" value="NSJP_2634"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2634"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="246" mass="25610" checksum="AD9958B8BD425B2B" modified="2017-06-07" version="1">MASLAGNLTAVGNSLDCSLFFARQPEPDLEFTEEELDQTAATKPATPTKQPKKSGGGRPLLWVLLLLLIGGIGYVAMEPEQLTVWLAPLLGDSTPKQTVPPVATAPRPQQEDLPIPPPPAPATTDMAPAAPADPASMPPSSTMPQAASHQVPPMDAPASVSPGRATASPLFGEGQRVTVMGNPTAPGEMVQLTLDPAGAKAGPAIRPGATLSILDGDLQPSGWVYSVRSDDGVKGWVSEKRLRMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7B3</accession>
    <name>A0A1W1I7B3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type II secretion system protein J</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_2730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GSP J family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2730"/>
    <dbReference type="EnsemblBacteria" id="SLM48897">
        <property type="protein sequence ID" value="SLM48897"/>
        <property type="gene ID" value="NSJP_2730"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2730"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010055">
        <property type="entry name" value="T2SS_protein-GspJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11612">
        <property type="entry name" value="T2SSJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="205" mass="22903" checksum="819731992D7AF082" modified="2017-06-07" version="1">MSFRPPRSEQGFTLVEVLLAVALVAVIATMVFSALYLTASAIDRTRTSATEEQLLRSTLRVMAEELAMSLQHPASPWLGINAQQGGEPADTIAFLTVGPFRPVSATTDTEMVRVVYTRNEASLMRIVRRNLFGINDESLEQMEMAKKVRGFNVRYYNRTGNIWTDEWDGRARSGVPMAVLIELTLEQDTPEPRIIRQWVSVGAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7C8</accession>
    <name>A0A1W1I7C8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2755"/>
    <dbReference type="EnsemblBacteria" id="SLM48922">
        <property type="protein sequence ID" value="SLM48922"/>
        <property type="gene ID" value="NSJP_2755"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2755"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="197" mass="21601" checksum="1B835468DF0E06B6" modified="2017-06-07" version="1">METGLHWIEQYGYGGLFILLMLGVLGLPVSDETLLVFAGYLSAKGTLRIEPAFIAAFLGSVAGISLSYAIGRFVGLPAIEKFGHLIHMKPEHLTASRRWVERWGKYSLLVAYFIPGIRHLAALLFGAAKLSPGVFARFAYAGALVWSASFIGLGYAAGEEWTKFSPLIHRTLTVVVLLMLFALSITLSVCLIRRVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7H7</accession>
    <name>A0A1W1I7H7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2799"/>
    <dbReference type="EnsemblBacteria" id="SLM48966">
        <property type="protein sequence ID" value="SLM48966"/>
        <property type="gene ID" value="NSJP_2799"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2799"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014262">
        <property type="entry name" value="Extracellular_HAF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02913">
        <property type="entry name" value="HAF_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="603" mass="61736" checksum="3FB7FF7FF8FA18F2" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7M6</accession>
    <name>A0A1W1I7M6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdenum ABC transporter, periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">modA</name>
        <name evidence="4" type="ORF">NSJP_2827</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2827"/>
    <dbReference type="EnsemblBacteria" id="SLM48994">
        <property type="protein sequence ID" value="SLM48994"/>
        <property type="gene ID" value="NSJP_2827"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2827"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="275" mass="29956" checksum="EAB2CA31BB4F0E9C" modified="2017-06-07" version="1">MNNFYQRVSTLSLFLGIVVFGPGIATDTYAQPETVTIAAANSLRDVFRKVLPLFEAQHPEVVVRVIYGPSQNLRKQIEEGAPVDVFLPSLLEEIDSLEKKSLVIQGTKRVYAGTSLVVITGKTFPAPVGSLQELRTVPVRRIAIGDPKTSSVGKVAIQFLKHAKLEPQLKSQYVFGQHSRAVLDLVAKGEAEIGIVYRTDAVAESQVKILDTAPEDSHTPVQYGVAAVWTAKNISAAGDFIEFLLSAPVQEQLKQFGFDQATPGATLAKRREVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7N0</accession>
    <name>A0A1W1I7N0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="3 12">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">moaA</name>
        <name evidence="14" type="ORF">NSJP_2646</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="3 12"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2646"/>
    <dbReference type="EnsemblBacteria" id="SLM48813">
        <property type="protein sequence ID" value="SLM48813"/>
        <property type="gene ID" value="NSJP_2646"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2646"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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</entry>
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                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
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                <person name="Swayne D.E."/>
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</entry>
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                <person name="Scott M.A."/>
                <person name="Spackman E."/>
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                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
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    <sequence length="260" mass="28422" checksum="3D85538B7F73EA62" modified="2017-06-07" version="1">MRCASRHSAVSLTVTSPFGLGRQGLIGLILLTLMAQAVPVFSAPSADSSQSNEPRILYIPPKKFMPRARLGGTVRGSDGLEPIVQPLVPDHVGFTSQETPVLNWYLSKPTPHEVRFTLIDDKSVKPIFEAPIPAPKEAGIFSIRTRDLDLTLQPGVQYRWYVSIVQPAPFSEIVTGGIIERCELSDCLIVMDARMTCSVQSVTENARAGMWYDAMGCLCALIDADPENVSLRRLRASLLSQVGLHLVAEWDLRAVPAAGR</sequence>
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        </source>
    </reference>
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    </evidence>
    <sequence length="140" mass="15684" checksum="1D86F702B073C5C5" modified="2017-06-07" version="1">MQFDAALAAREAFQRSQMQLGPDWLTAVDLEDRFSSSAGASAREAYEHLLLLAAAHPNADAFHAFCIYITWQQVTEETIPRHFRTGLELCESYLGSPEGKDPRDIDYVTELLESFRAGLGLTEEDDIAVEYRRDTPKGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I874</accession>
    <name>A0A1W1I874_9BACT</name>
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        <name type="scientific">Nitrospira japonica</name>
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        <lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
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        <property type="protein sequence ID" value="SLM49059"/>
        <property type="gene ID" value="NSJP_2892"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2892"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012664280" evidence="2">
        <location>
            <begin position="26"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="527" mass="58961" checksum="41AEA853CA9D6BFC" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8D7</accession>
    <name>A0A1W1I8D7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49063">
        <property type="protein sequence ID" value="SLM49063"/>
        <property type="gene ID" value="NSJP_2896"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2896"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025489">
        <property type="entry name" value="DUF4381"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14316">
        <property type="entry name" value="DUF4381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="167" mass="18576" checksum="56813B9DD87BBCF2" modified="2017-06-07" version="1">MDQGAHSLEALKEIPLPDPVPYIPQTVGWLLIGALALGAIGYGLWRVVRYRAANRYRLAALKELAEIESRIDNADERHRALTAIPALLKRTAMAAAGRQTAAALSDRAWWEFLDRTYASGGFSNGPGRLLTLFSYAEPSKLAVVPESEIRDVIVLVRRWIKEHHAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8E5</accession>
    <name>A0A1W1I8E5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49318">
        <property type="protein sequence ID" value="SLM49318"/>
        <property type="gene ID" value="NSJP_3151"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3151"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="133" mass="14857" checksum="AA96FD840A6AD50E" modified="2017-06-07" version="1">MVTDLLRYLHRHTREGRKALPVFLLACLLIGIRLIAGTISEACFFDLELTADRTVHLHSANDHAHCNHGRFNVAPLVAWACSVCKDVNAYTLPEVPRLPILVSFFVPLFLLVVSFGRRPLIAAHGRGPPFLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8F3</accession>
    <name>A0A1W1I8F3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_3119</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3119"/>
    <dbReference type="EnsemblBacteria" id="SLM49286">
        <property type="protein sequence ID" value="SLM49286"/>
        <property type="gene ID" value="NSJP_3119"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3119"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM49286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="377" mass="41495" checksum="643865BF88566775" modified="2017-06-07" version="1">MSRPFGLYVHIPFCRRRCDFCAFYLEVHHPAAAGRFLAALHTEIALHARQEAIQGRPLSSVYFGGGTPTALETSDLTGILDGIRNHFDLLPDCEVTIEAHPSTVTMNDLSTLLGAGFTRVSFGAESMEDTELARIGRSALAGETVTAVRHARRAGFTNVNLDLMYGLPGQSVASWLSTLEQCLDLTPSHLSCYALTIEPGTALASDVESGRCLPPDEGLQVAMEQAADATVHEAGYIRYEISNYAKPDRMCRHNLLYWTHGEYLGLGPSAQSFVDGSRFGKTADLNIYQRDLAAQRLPLSDHAVLSDPEKLRDSVIFGLRLLQGIPTASLSAHSGNYGHEHALKHLREERLIEEVDRYTRLTAKGRLYADHVAELLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8G5</accession>
    <name>A0A1W1I8G5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_2982</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; alginate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49149">
        <property type="protein sequence ID" value="SLM49149"/>
        <property type="gene ID" value="NSJP_2982"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2982"/>
    <dbReference type="UniPathway" id="UPA00286"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031811">
        <property type="entry name" value="ALGX/ALGJ_SGNH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16822">
        <property type="entry name" value="ALGX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0016">Alginate biosynthesis</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="466"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="580" mass="65959" checksum="5C70493E96C52084" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8J4</accession>
    <name>A0A1W1I8J4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
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            <taxon>Nitrospira</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49179">
        <property type="protein sequence ID" value="SLM49179"/>
        <property type="gene ID" value="NSJP_3012"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3012"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="39" mass="4144" checksum="31A256B9421047DA" modified="2017-06-07" version="1">MADCSSQEFLAVYPSVVGFGGWFMGIVVSDSPVGQLKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8V3</accession>
    <name>A0A1W1I8V3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA_pol_B_exo2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3184"/>
    <dbReference type="EnsemblBacteria" id="SLM49351">
        <property type="protein sequence ID" value="SLM49351"/>
        <property type="gene ID" value="NSJP_3184"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3184"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF10108">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="88"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="238" mass="27194" checksum="99B3EEA9DA4C1625" modified="2017-06-07" version="1">MKVVLDIETIQAPREEWERLLGKPPSQVDPAQASDEMDLFTAGAAAERRRIEDEQYAKSAFDGTFSAIVCIGLLEFSDQLEPRGAVAWYGSNEQELLRQFWSRVAQARPSLFITHNGLGFDLPFIKKRSIIHQVKPAFDVNLAKFRTDPVYDTMAIWSNWDQRGWVKLDVLARALNVETKSGSGDQVAQMWEKGQGQELALYCLQDTFVTYACYCRMNFRQPLSREVVLLQPELIDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Z6</accession>
    <name>A0A1W1I8Z6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3106"/>
    <dbReference type="EnsemblBacteria" id="SLM49273">
        <property type="protein sequence ID" value="SLM49273"/>
        <property type="gene ID" value="NSJP_3106"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3106"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="188" mass="21225" checksum="F433A85CA84735E1" modified="2017-06-07" version="1">MSGRLASSPHRISRALAVCLLWIPYVSPIDQAVSAGIEIYFAPEEAPLDRVVSLYGKARRYIYVSVYGLTSPRAVEALVAAKKRGLDVRLMTDQGRAQDIKQRSALRTLRSAGIPIRVNRHDGLMHLKQVVIDDDVNTSGSMNHTTSGNRYNDERLDIVTDHATTVKAREKFLAMWNDRERFESWVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9A3</accession>
    <name>A0A1W1I9A3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49570">
        <property type="protein sequence ID" value="SLM49570"/>
        <property type="gene ID" value="NSJP_3403"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3403"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="121" mass="13583" checksum="2F64A393D5E4E3B4" modified="2017-06-07" version="1">MAVTATEQVDIAAALVRLYVFLAQYLDRCLDESARKAYPDAELKKHLTDTRRQLMDILSVNPVVKKKLTEECDRILALGEACLRGASADRQVHETMQVERIALKHKTSALSDLVAVFRALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9P7</accession>
    <name>A0A1W1I9P7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
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            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3600"/>
    <dbReference type="EnsemblBacteria" id="SLM49767">
        <property type="protein sequence ID" value="SLM49767"/>
        <property type="gene ID" value="NSJP_3600"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3600"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="150" mass="15698" checksum="134F2A35CCB7C3E6" modified="2017-06-07" version="1">MAAMTSKAIGMATGIIGLAAIAAWLGLAHSCDPQSGEPVIGGQVQISPALANQVRPTDVLFVIVRRPGGPRPIAAKRIDQPVFPVPFEITNADVMVQGSELRGMVDVVARLDRDGQAGPAQPGDIEGRYAKNPTLPGGRNLEIILDSVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Q5</accession>
    <name>A0A1W1I9Q5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Streptomycin 3''-kinase</fullName>
            <ecNumber evidence="1">2.7.1.87</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.87" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49777">
        <property type="protein sequence ID" value="SLM49777"/>
        <property type="gene ID" value="NSJP_3610"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3610"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050299">
        <property type="term" value="F:streptomycin 3''-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006748">
        <property type="entry name" value="NH2Glyco/OHUrea_AB-resist_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04655">
        <property type="entry name" value="APH_6_hur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="278" mass="31052" checksum="664179870CB48641" modified="2017-06-07" version="1">MTRIHDNQPPDISYYCDKWTLSFPIRLAQTPTSALFRVTRLDQQAILKVLTPKGRTLEGNGSSALKCFQGPRAVKLLDSDDGAMLLEHLDGGELSHLVKQGSDAQAAHIICDVLDALHSYAGETPAGIQGLHHEFQSLFTRARGEKPDSIFRRAAKVAETLIATESNRRLLHGDIHHGNILKSSSRGWVAIDPQGLFGERTYDVANSFFNPDEVPHMVGTRERIDLLATIFSERLQVDRLRILQFAYAHGSLSASWHIDDGESPQWRLHMTSLIEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA25</accession>
    <name>A0A1W1IA25_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3675"/>
    <dbReference type="EnsemblBacteria" id="SLM49842">
        <property type="protein sequence ID" value="SLM49842"/>
        <property type="gene ID" value="NSJP_3675"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3675"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="337" mass="37917" checksum="EDA46C3E91CF2A21" modified="2017-06-07" version="1">MNPLVSVVIPTYNRGWCIERTLESVFAQTHKNIEVIVVDDASTDDTAERLAPFLDKITYIRHSTNQGIALQAEGGPARNTGIGRATGDYLAFLDGDDLWEPDKLAVQVQAAARFPQAGLIVADGFPFSHEDGTILRSSLLHDYGDDFCGSLPEGAVVEADLYHRLLRGCVIDTPSQVMVPSKVLQTVGNFAQHRADDYDFYIRLAAQFKVVLIKKHLVKYRVHTGNVSGPVAMQFFQFTQPNLLIRKKHLKVCRPEVRPLVKQQIKEGLVTAAEKARDEGLRGQRRWASRFLWRLLMKNPFEPGSLYVALSLVGLWTPGWVLATFRPVTRRMLRHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA82</accession>
    <name>A0A1W1IA82_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49821">
        <property type="protein sequence ID" value="SLM49821"/>
        <property type="gene ID" value="NSJP_3654"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3654"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="86" mass="9660" checksum="6422B2BA1DBB00C9" modified="2017-06-07" version="1">MAFYQPNTRDQPRDPTRPVYGNLNPVAPDGGDYHSIEVKATDPDARYTKPCPGDPPIVTKEPFEAAYVLHILRGKNTYNRESPFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAA4</accession>
    <name>A0A1W1IAA4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49922">
        <property type="protein sequence ID" value="SLM49922"/>
        <property type="gene ID" value="NSJP_3755"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3755"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="91" mass="9665" checksum="63373E87E857B86B" modified="2017-06-07" version="1">MTAILNLIYCWLLDMLAKLTDIALNAWDSVLGPADSILSSIGTGGLTIPVIPAQYAWILGATGMAQAVAIIATAMLVRFTLQSVPFVRWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAA9</accession>
    <name>A0A1W1IAA9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49703">
        <property type="protein sequence ID" value="SLM49703"/>
        <property type="gene ID" value="NSJP_3536"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3536"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="91" mass="10042" checksum="B611AF673B2C0380" modified="2017-06-07" version="1">MEGERGIDRSISKRHHGIAGGRVLRGLVDKVCENCSAIFACGGYQCWCGGLEITRSQMKWIAERFRDCLCPVCLKKVSTGELGPRISDPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAE3</accession>
    <name>A0A1W1IAE3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta_helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3795"/>
    <dbReference type="EnsemblBacteria" id="SLM49962">
        <property type="protein sequence ID" value="SLM49962"/>
        <property type="gene ID" value="NSJP_3795"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3795"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="3">
        <location>
            <begin position="236"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="481" mass="51611" checksum="719CCB321F953C03" modified="2017-06-07" version="1">MHNPSFTNEPCSHRARYFQMNVTPWLEESKRSHLTRIARLGCIRVFVLGVTLFAGTIAEAATYYVATNGSDSRTCGVATNASNAKRTIGSAVGCLMPGDTLYIAGGTYVERLDSNSMTIPAGTSWTQAVKIAASPGQVVTMRPGAGPAVVNLAHPYIQYVIFDGIIFDGSNTGSDVIGLNGGAHHVRFANSEIKNGRYNGIILSFNYNGAARFNEFINLKVHDNGYTNGVPDDYFHGFYITTDSNLIDGCEVYNNAGNGGKFYDTPSGNVFNNVVRNSIFHDNSKDLDPDRWSAGFFTSSGTGNQIYNNIAYNNYIGFAVLRGGNGNILYNNISYANEIAGINIDAANGSLTGAKVYNNTIVNNGRFGILLSNAPTDTAITNNIVYQNPTNIYSDGTDKRTVLKTNLLVDPKFKNAAARNFSLQTGSPAIDAGTALSEVTTDFSKVQRPQGSSYDIGAFEGGDGPTADTTPPLPPTNVQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAK2</accession>
    <name>A0A1W1IAK2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="8">6.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">acsA</name>
        <name evidence="8" type="ORF">NSJP_3855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.1" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3855"/>
    <dbReference type="EnsemblBacteria" id="SLM50022">
        <property type="protein sequence ID" value="SLM50022"/>
        <property type="gene ID" value="NSJP_3855"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3855"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="7">
        <location>
            <begin position="30"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="5">
        <location>
            <begin position="86"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="6">
        <location>
            <begin position="528"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM50022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="629" mass="70127" checksum="DCA7BBECEC179A91" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAL5</accession>
    <name>A0A1W1IAL5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="8">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glycyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="8">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">glyQ</name>
        <name evidence="9" type="ORF">NSJP_3868</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3868"/>
    <dbReference type="EnsemblBacteria" id="SLM50035">
        <property type="protein sequence ID" value="SLM50035"/>
        <property type="gene ID" value="NSJP_3868"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3868"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00733">
        <property type="entry name" value="GlyRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00254">
        <property type="entry name" value="Gly_tRNA_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006194">
        <property type="entry name" value="Gly-tRNA-synth_heterodimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002310">
        <property type="entry name" value="Gly-tRNA_ligase_asu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02091">
        <property type="entry name" value="tRNA-synt_2e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01044">
        <property type="entry name" value="TRNASYNTHGA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00388">
        <property type="entry name" value="glyQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50861">
        <property type="entry name" value="AA_TRNA_LIGASE_II_GLYAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM50035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="303" mass="34909" checksum="D889000350C9D040" modified="2017-06-07" version="1">MTFQDLILTLHRFWADQGCVIHQPYDLEMGAGTFHPATFLRALGPEPWRAAYAQPCRRPTDGRYGENPNRLQHYYQYQVVLKPSPDNIQELYLESLARLGINPKQHDIRFIQDDWESPTLGAWGLGWEVRLDGMEITQFTYFQEIGGIELSPITGEITYGTERIAMYLQQVNNVYDLAWTDQIKYGDIHHESEVQFSRYNFEEANVDMLMSAFQAYEAESKRLLGHSDRRLALPAYDYCIKSSHVFNLLDARGAISVAERTGYIGRVRALAKQCAERYIEERAAMGHPLIERRPKTAGSRGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAN6</accession>
    <name>A0A1W1IAN6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CrpH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">crpH</name>
        <name evidence="1" type="ORF">NSJP_3772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3772"/>
    <dbReference type="EnsemblBacteria" id="SLM49939">
        <property type="protein sequence ID" value="SLM49939"/>
        <property type="gene ID" value="NSJP_3772"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3772"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="415" mass="45676" checksum="C2AE05FD5D50A917" modified="2017-06-07" version="1">MMDRSTRVLVVGGGPAGSTTTTLLAQRGVDVILAEREQGARYHIGESLLPSCLRILDLLGVREKVERHGFVRKDGGYFVWGEQPWEAAFGSLTTPLYGFQVVRSEFDKILIDHASSQGVSVLEGHEVKQLDLVDGRPVAAPAVDSEGNRVRLTFDFLVDATGRSGLMATGYLRNRYYHKAFMNVATWGYWRKAKRLSVGPQGAIATCSIPIGWIWAIPLHDGQLSVDVVMHKSKFKPLRQHLSLEGVYRHALAYSELIQDLISGGELQLPLRAETDYSYTAEEFAGPGYYLVGDAACILDPLLSTGVHMATFSGLLTAASLSSAISGDVPASDATQFYSASYRRAYLRMMVVVASFYQTHRGAEAYFRQAQQLTSHDYSGAELAHAFLHIISGIEDLKDIEDVEPQRLLEALTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAP8</accession>
    <name>A0A1W1IAP8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3888"/>
    <dbReference type="EnsemblBacteria" id="SLM50055">
        <property type="protein sequence ID" value="SLM50055"/>
        <property type="gene ID" value="NSJP_3888"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3888"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="558" mass="62309" checksum="E12E0844DD040D41" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAW6</accession>
    <name>A0A1W1IAW6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative General secretion pathway protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_4011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4011"/>
    <dbReference type="EnsemblBacteria" id="SLM50178">
        <property type="protein sequence ID" value="SLM50178"/>
        <property type="gene ID" value="NSJP_4011"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4011"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005644">
        <property type="entry name" value="NolW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038591">
        <property type="entry name" value="NolW-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03958">
        <property type="entry name" value="Secretin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Secretin_N" evidence="6">
        <location>
            <begin position="270"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="756"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM50178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="782" mass="85326" checksum="C383F954386967B2" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAX5</accession>
    <name>A0A1W1IAX5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50135">
        <property type="protein sequence ID" value="SLM50135"/>
        <property type="gene ID" value="NSJP_3968"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3968"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="250" mass="27551" checksum="CA1D2762B2202C2C" modified="2017-06-07" version="1">MDSEIFGAWVATGLTLFIFSFLYKDNPLFKLAEHLYVGVSVGYSIVKTFDSVILHLIVKPIFEQGEFSLLIPVAIGLLMLTRYVPRAAWMSRYAFAFIVGVGSGLAIPRTISSFILKQIEDTVRPLLSLVGQDGITFSMSLLNPASNLNAIIILIGVSSVLFYFFFSIEHQGAGKVVARTGVFFLMIAFGAAFGYTVMARMSLLIGRLTDMIEFSDASYGRPTLWLTILTIAALILLARRQEGEPPVSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAX6</accession>
    <name>A0A1W1IAX6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Multidrug resistance outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3882"/>
    <dbReference type="EnsemblBacteria" id="SLM50049">
        <property type="protein sequence ID" value="SLM50049"/>
        <property type="gene ID" value="NSJP_3882"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3882"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="503" mass="55745" checksum="7ED8F21F593A7600" modified="2017-06-07" version="1">MTRTFRTAMRAGFSAVGAYALLITAGCAWIPKGDPPAAYLDTPELKETLEEVSNRLQNWPDDRWWEQFKNPELNGLMGQALKDNPGLKAASARLREAQALVRVEGARLLPFLEADASLTYERISQHGVFAALNPEVAGAHILLGVINPLSLRYEFDFWGKNRATIEAALGQAAAEEAEQAEIRLRLTAGIARAYFRGQALHRQLELVRSIVELRRGLRRLAETRYELGLDTDLAVKQSIAEYEAAAKRLSGVRDQLDVQRHLLARLIGKGPDEALRFFGKTGVTIPEQIPVPEHLSMGLLVHRPDLAAALYRADSAARMVKVAKTQFYPTIDLTAFAGFNALTLTKGADKLANFLFSGQSFSYGMAPGLRLPIFEGGRLRGELAAHRAEYDAAVELYNDTLLGALREVADSLSAWQSTREMLDSHRRLVTALSEDWRLAKVRLVSGLDDDREVLRHRYPVLEQEYAMRALESDQLVSAVDLIEALGGGYRNDDVSKRPAQQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAY4</accession>
    <name>A0A1W1IAY4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General secretion pathway protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gspF</name>
        <name evidence="11" type="ORF">NSJP_4007</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4007"/>
    <dbReference type="EnsemblBacteria" id="SLM50174">
        <property type="protein sequence ID" value="SLM50174"/>
        <property type="gene ID" value="NSJP_4007"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4007"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001992">
        <property type="entry name" value="T2SS_GspF/T4SS_PilC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00874">
        <property type="entry name" value="T2SP_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="10">
        <location>
            <begin position="72"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="10">
        <location>
            <begin position="274"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM50174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="403" mass="43280" checksum="41D00B9A22709895" modified="2017-06-07" version="1">MPVFSYRIARPDGSTLDGQVEGEEEQLVRAKLEGQGYLVFKLQRRGGAVGGSTLSLSPFRGLPLGEFLIFNQELLALVKAGLPVLRVWDLLIERARHSGFQQVLRMVRQDIRGGASVSEALAKHPAYFSELYIATFKAGEQSGNVGDVLQRFITYLKLMLGLRQKVAKALAYPGFLILVGVGVVGFLLAYVMPTFISVYSESAKTLPVATQALIDLVTAAHAYLIPTAVSLAAVLLAGRAYYATPPGHLAADRMLLRAPLLGQIFVKHHTIQLARTLGTILAGGTPLVDALQITKGAVSNRYIAGGIGEAVDDIREGTTLAAALGRPGVFPKLAIEMLSVGEETGALEAMLHDVAEFYEGDLDLRLTQLTTWIEPVLLLVMGVLVGGIVIVMYLPVFQMAGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZI9</accession>
    <name>A0A1W1HZI9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl transferase (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0004"/>
    <dbReference type="EnsemblBacteria" id="SLM46176">
        <property type="protein sequence ID" value="SLM46176"/>
        <property type="gene ID" value="NSJP_0004"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0004"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="333" mass="37926" checksum="8A36B70CEAF989DC" modified="2017-06-07" version="1">MLSIIVAVHNQLGHNQLFLEGIKAYTTGSYEVIVIDNHSSDGSADFFEAEGCRVIRNDRNLCYPESMNLGSRAARGDMLCHINNDLYVAPGWNGRLTKAMDRLELDVASPLGLEMMPTPALTDWMQGRWAAIGQGRLSSGKPADRLRTMVRVMYGDWEGYCEEVHRAFSDTVFEGIVGSCVMIRRSAYEKIGGLDERVQAADWDLYYTLRKRELTTGDLRRCMVLGATFVHHFIRATVKSKREPFACTHERWSIDQKWDRREQADLWCKPEDFARSGLGESVGRRLGKPLKKLALELDRLSAWRRLWVPPQRVVEQYRRQFAALGSPAASRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZK4</accession>
    <name>A0A1W1HZK4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Oxidoreductase, Gfo/Idh/MocA family</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0016"/>
    <dbReference type="EnsemblBacteria" id="SLM46188">
        <property type="protein sequence ID" value="SLM46188"/>
        <property type="gene ID" value="NSJP_0016"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0016"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="321" mass="34784" checksum="B7A35136BEDC1B8A" modified="2017-06-07" version="1">MIPLRAGVIGVGHLGQHHARLYAAIPGSQLAGITDLSPDRAKVIADKLGTKVFSDLGELLPHVDVVSVAVPTSAHHAVAKACLSAGKHVLVEKPIAVTSAEARELVQLAKQRGLCLQVGHSERFNPVMQVMRPHIGRPAFIECHRLSSFSERGTDVDVVLDLMIHDLDMVLSFDPGPVEEVRAAGVPVLSSTVDIANARIQFKGGCVANLTVSRVSTNKMRRFRVFQRDSYVSIDFQTRQGMVCRREQQEAPRPSIVVQQLQGGDEEPLKLQLTSFLESARTGARPVVSGEDGALALELAHQVLKAIESFTQRHEEPGATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZP4</accession>
    <name>A0A1W1HZP4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein NSJP_0056</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0056"/>
    <dbReference type="EnsemblBacteria" id="SLM46228">
        <property type="protein sequence ID" value="SLM46228"/>
        <property type="gene ID" value="NSJP_0056"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0056"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00252">
        <property type="entry name" value="TIGR00252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="135" mass="15329" checksum="44B688247E961D49" modified="2017-06-07" version="1">MSSSVRILDPRRLFGQEGEAAAEDFLIRKGYRIVARNLRSSLGELDLVAEDGPTLVFVEVKARRTEEFGGAAYAVHEQKQQKLIRLAAQFLARHHWSRRSCRFDVVLVQQRAGSGPPRIEHICDAFDVPGDDLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I070</accession>
    <name>A0A1W1I070_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredox_DsbH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0071"/>
    <dbReference type="EnsemblBacteria" id="SLM46243">
        <property type="protein sequence ID" value="SLM46243"/>
        <property type="gene ID" value="NSJP_0071"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0071"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="2">
        <location>
            <begin position="21"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="697" mass="77981" checksum="74B62952F8961F6B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I078</accession>
    <name>A0A1W1I078_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0301 protein NSJP_0081</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0301 (AlgH) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0081"/>
    <dbReference type="EnsemblBacteria" id="SLM46253">
        <property type="protein sequence ID" value="SLM46253"/>
        <property type="gene ID" value="NSJP_0081"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0081"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00758">
        <property type="entry name" value="UPF0301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003774">
        <property type="entry name" value="UPF0301"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30327">
        <property type="entry name" value="PTHR30327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02622">
        <property type="entry name" value="DUF179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="186" mass="20469" checksum="F12ED69F5EDE09D8" modified="2017-06-07" version="1">MQLPLGKGIFLIAAPTLRDPNFRQTVVLLCEHGADGALGVVVNRPTAMSVSEALPHVPVLEGQRHVLFSGGPVQPNQVMLLYRLNQMPDNSHHVFDGVCLGGDVELVDRILTTNQGREAFRAYVGYSGWGPGQLESEMKTGSWITIPADPNIVFEKDPLRIWPDIVSALGEEYRHYADMPIDPCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0B8</accession>
    <name>A0A1W1I0B8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46450">
        <property type="protein sequence ID" value="SLM46450"/>
        <property type="gene ID" value="NSJP_0278"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0278"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="91" mass="10242" checksum="E56D562B80958846" modified="2017-06-07" version="1">MGQTSTLWKSNYMEKKKTRPSYKPKIRWELLGLPFPDSGTTTPIETIRKGVSVLASQGFQPGTSRTEHTTRGRGHSRMVGGNNARRRRPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0F0</accession>
    <name>A0A1W1I0F0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46476">
        <property type="protein sequence ID" value="SLM46476"/>
        <property type="gene ID" value="NSJP_0304"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0304"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="68" mass="7946" checksum="E92D70BF83F7E9A4" modified="2017-06-07" version="1">MGNDLTKREQEILKWLIHGMSNKEIAEKESISPRTVQKHLQRIYQCLGVQTRAEAIVFIHQDGKHLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0G8</accession>
    <name>A0A1W1I0G8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0300"/>
    <dbReference type="EnsemblBacteria" id="SLM46472">
        <property type="protein sequence ID" value="SLM46472"/>
        <property type="gene ID" value="NSJP_0300"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0300"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="929" mass="96939" checksum="FA8782DE9E9CF130" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0H0</accession>
    <name>A0A1W1I0H0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_0295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0295"/>
    <dbReference type="EnsemblBacteria" id="SLM46467">
        <property type="protein sequence ID" value="SLM46467"/>
        <property type="gene ID" value="NSJP_0295"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0295"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032687">
        <property type="entry name" value="AraC-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12625">
        <property type="entry name" value="Arabinose_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="219"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="347" mass="38828" checksum="6785AA7B29365E3F" modified="2017-06-07" version="1">MNGGHRMCELGSFVPYLLSKGEQPGKVLKKVGFPTHLLLDPDAWVPRELFLTLVNALSSTTGDPHCGIHVGEMESFVQFDAFGTAILNAPTLRTAINVACRRITLIQTGTEIRLSEYRRTARLSYSLLGRTGENPAQYFQGVLVFFQNILALTGQPAVVDVAFDHVPCRKSDELERVFGPRLVFRAGENAVVFDRGLLDLPLQFSKTAIQILPDRPVEEEVVRAVLSNMSDQLVYETPSLETTAGVLGLHPRTLERRLTGWGIPFESLLDDFRRNRSLQLIHEGTHTLTDIAFLVGYSDAAHFTRAFRRWTGRPPRDYVRGLRLSREFSTPRPPQRHSSHVVIAADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0H4</accession>
    <name>A0A1W1I0H4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46508">
        <property type="protein sequence ID" value="SLM46508"/>
        <property type="gene ID" value="NSJP_0336"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0336"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="76" mass="8760" checksum="D745A639413B02C0" modified="2017-06-07" version="1">MPAVQQTTDQILEAVREHPDCTLDELVEHLPAFHWSHIFLEVDHLSRTGRLQLIRTGSGFVTTLRISKPRRADERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0K8</accession>
    <name>A0A1W1I0K8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46524">
        <property type="protein sequence ID" value="SLM46524"/>
        <property type="gene ID" value="NSJP_0352"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0352"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012461454" evidence="2">
        <location>
            <begin position="35"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="551" mass="59403" checksum="E42A5235578981E6" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0M7</accession>
    <name>A0A1W1I0M7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
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            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46532">
        <property type="protein sequence ID" value="SLM46532"/>
        <property type="gene ID" value="NSJP_0360"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0360"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="320" mass="33845" checksum="7912484C4C767052" modified="2017-06-07" version="1">MRQVGRPIEPMIGTVLLGLLIAACSTTDNSSDKRVAQPTPPVAPVPAASPDEGSASVGDGGEVASRRVLPSDPCLSSADINCRNRINQLKDVRRELANPTAPPTIPPVPANGGRCVVDVQGQYGPPVGQPGARGSYRHFEVQLWIVTSMPIPGQSATRRSYAVQWATSGSGDRGDDNGVGTSDHWTWTIAGSRASSIPTVMTGEPQLTALNSAGGNWIVNMLPTAFPGGIRETQQHVIAGSPVPPPVQVQKMSNAFGYQPFGQISGMPIMDSNGTLTTKESKVFPIDAVQNRNVPNMMPAYQNMMPRGTVDCTWNLTLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0U7</accession>
    <name>A0A1W1I0U7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46604">
        <property type="protein sequence ID" value="SLM46604"/>
        <property type="gene ID" value="NSJP_0432"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0432"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="90" mass="10392" checksum="77C145E6F90EF849" modified="2017-06-07" version="1">MACKLIETIRTVQATPLRWKRNGHGQRQVKVVRSSLSLKARSVSVRRRPLLRLAAELDPSRLPSNGSANSPRHPFQRAAPYRQRRRTKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I163</accession>
    <name>A0A1W1I163_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46738">
        <property type="protein sequence ID" value="SLM46738"/>
        <property type="gene ID" value="NSJP_0566"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0566"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="56" mass="6268" checksum="CA3193F0048CBF77" modified="2017-06-07" version="1">MKSLGTRSWTNHRIARRSALVPRADGRSLDALRSVPEDRGEIWKEKLAGGLGIEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1A6</accession>
    <name>A0A1W1I1A6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46772">
        <property type="protein sequence ID" value="SLM46772"/>
        <property type="gene ID" value="NSJP_0600"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0600"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="89" mass="10652" checksum="F6953106C66AAC05" modified="2017-06-07" version="1">MTKHWFEFPEPEKPGLPSVWNGRIIRLMYLVSPLQQGDVQWLEIEWDIGRCTWAYVKKNEDIWRLHVARIQAKVDGGIKERIEAYPVWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1B6</accession>
    <name>A0A1W1I1B6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0626"/>
    <dbReference type="EnsemblBacteria" id="SLM46798">
        <property type="protein sequence ID" value="SLM46798"/>
        <property type="gene ID" value="NSJP_0626"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0626"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021352">
        <property type="entry name" value="DUF2971"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11185">
        <property type="entry name" value="DUF2971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="324" mass="36287" checksum="59F0DCAD8BDD9785" modified="2017-06-07" version="1">MGRSHIRNVPAEASGGQSWGKHSAVPPGGFSLVRVPIAMISELNRELYAATTGVPLYHYTSLAGVKGIIDTGLLRATEITYLNDSTEMAHTVSQLDPETWFREGFGKLESKLFVQFREWISHRLTAGHKLYVGCFTANGNLLSQWRSYCPPTRGVNLGFNGAKLTASACDQGWKLGKCIYEQDKKEEIAIEVLNEIEDLAERKGAKAGSFQHIFEELETHLLEIAALLKHPAFHEEQEWRIVSPVITNYVEADIEYREGASMLIPFMKFGLPHAPDRRVDLEHVYLGPTPNSNISMESLSNYLSKFGASPRNGVQYSNVPYRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1G5</accession>
    <name>A0A1W1I1G5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proline iminopeptidase</fullName>
            <ecNumber evidence="1">3.4.11.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.11.5" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0684"/>
    <dbReference type="EnsemblBacteria" id="SLM46856">
        <property type="protein sequence ID" value="SLM46856"/>
        <property type="gene ID" value="NSJP_0684"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0684"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="115" mass="12784" checksum="0CB44C9A68A7AEDF" modified="2017-06-07" version="1">MAARALVSGLVTPWELLSIHRGNRVSLEAMTPELLDLNLERAVPSVGVPVFFFLGRYDRHVDSASAARYFEVLRAPKHLIWFEDSAHNIPFEEADAFNEAVVEALQSLGIAPQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1I7</accession>
    <name>A0A1W1I1I7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Deoxyribodipyrimidine photo-lyase</fullName>
            <ecNumber evidence="7">4.1.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">phrA</name>
        <name evidence="7" type="ORF">NSJP_0680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA photolyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.3" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46852">
        <property type="protein sequence ID" value="SLM46852"/>
        <property type="gene ID" value="NSJP_0680"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0680"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901363">
        <property type="term" value="F:heterocyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097159">
        <property type="term" value="F:organic cyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="PTHR11455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="481" mass="54860" checksum="DEF411E668D29BFC" modified="2017-06-07" version="1">MRGIVWLRRDLRLSDQPALTAACEACSEVIPLFVFDDPLLRSKTFGSVCVNFMLGCLEDLAASLAARGLPLQWRRGEPVEEVVTAAREWKVDVVYWNRDYEPAALLRDRAVQLQLAEQGVEVRTFKDHVVFEADEVCGITGEPMQRYSAYRARWWTKWQAVKPTLLPIPRGLCVEKAVPLPAPRPIPAARELGYEPLTPWIRAGEQHARKRLAWFVAEPIHAYVNSRNLPALDGSSKLSPHFRFGTLSPRTAIHMALASLATGGRVSRPDVLTWIDELVWREFFQQVLSAFPRVAGGPFRAIAVPPARESGPERDRFFQAWCDGQTGYPIVDAGMRQLNETGWMHNRVRMVVASFLIKDLRLDWQCGERYFMQRLVDADVAANNGNWQWCASTGTDAMRGYRIFNPALQSKKFDPDGAYIREYVRELDGAASKWIHEPHLMSPDEQVHARCRIGRDYPSPIIDHQQARREYLDLAKQQVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1Z9</accession>
    <name>A0A1W1I1Z9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acidPPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0717"/>
    <dbReference type="EnsemblBacteria" id="SLM46889">
        <property type="protein sequence ID" value="SLM46889"/>
        <property type="gene ID" value="NSJP_0717"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0717"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="97"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="365" mass="38270" checksum="411D83446EB55F02" modified="2017-06-07" version="1">MTADTSARPSAADSTGFVLASAACSCAAVVLAILNLLELDIPLTKFVRSLYHPVGYLPNLWLAYFSDIGDRIGKGDCMIALSLLLLLAGVWLKRADVKLAGWQTLAAHGIVAVLSNLLKHVVGRPRPKFIHTGAVDLSPFGGSGWDSFPSGHAMLAMAIAAVLAIRFPKGRWIFIGMAVAIAASRILRGSHFLTDTVGGAALGWLVGVVSGHPWRRWRLSLGCGLASLAPVCVGVSAAIWVAGHASPVQWAGSQLVLAGFFVTILSLIGYGWLALGLMPIRHLSKQTCKELAGMGVVMATGSALMAAAALCVCMAAWIRPRDVDSLSVTGDRAGDRVGAQDAVFCLLVILGLWASQAMRGLLPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I262</accession>
    <name>A0A1W1I262_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47082">
        <property type="protein sequence ID" value="SLM47082"/>
        <property type="gene ID" value="NSJP_0910"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0910"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="72" mass="8332" checksum="28D79D99CFC8E4E9" modified="2017-06-07" version="1">MKVVCSWCRYEGKNDVVGEKPPLDDVRETHGICLTHRDEVQARWRASRAYARDTGTDGLSPAPFRWKWRSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2A5</accession>
    <name>A0A1W1I2A5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="SLM47127"/>
        <property type="gene ID" value="NSJP_0955"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0955"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="79" mass="8813" checksum="7421DB2A06C4EFB8" modified="2017-06-07" version="1">MDSPPPIRVNWRMNAMMARFVGVVAIASGFVMGIYGLEDQGSRWLQTALGLLVTGMLAQGYALYCSIKRMQELHDRPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2E8</accession>
    <name>A0A1W1I2E8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable inorganic carbon transporter subunit DabA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dabA</name>
        <name evidence="7" type="ORF">NSJP_0995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of an energy-coupled inorganic carbon pump.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a complex with DabB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.</text>
    </comment>
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        <property type="protein sequence ID" value="SLM47167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47167">
        <property type="protein sequence ID" value="SLM47167"/>
        <property type="gene ID" value="NSJP_0995"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0995"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01871">
        <property type="entry name" value="DabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018752">
        <property type="entry name" value="DabA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38344">
        <property type="entry name" value="PTHR38344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10070">
        <property type="entry name" value="MpsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="760"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="775"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1066" mass="120932" checksum="2F0E1819C769441D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2I5</accession>
    <name>A0A1W1I2I5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Endoribonuclease L-PSP, YjgF-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1046"/>
    <dbReference type="EnsemblBacteria" id="SLM47218">
        <property type="protein sequence ID" value="SLM47218"/>
        <property type="gene ID" value="NSJP_1046"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1046"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="128" mass="13680" checksum="74CDC4AAEC10C4A5" modified="2017-06-07" version="1">MARQNVSTGGPWESKIGYSRAVRVGPSISVSGSTAMTPSGLVGKGDPYAQTIQTFKTIEAALKQAGASLSDVVRTRIYMVDIDQWQEVGRAHGEIFGAIRPATTMVEVKRLIDPDMLVEIEADAIVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2J8</accession>
    <name>A0A1W1I2J8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Amino acid/polyamine/organocation transporter, APC superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_1056</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1056"/>
    <dbReference type="EnsemblBacteria" id="SLM47228">
        <property type="protein sequence ID" value="SLM47228"/>
        <property type="gene ID" value="NSJP_1056"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1056"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="478" mass="50880" checksum="E31D85B07C4FD91E" modified="2017-06-07" version="1">MVCEAKEKEKRERLEISTPPDYTDGPMSLSPRSNSPSDGPHKTIGWFTASCVLVSNMIGGGIFTTTGIMARDLGDPLLILSLWLVGALFAIGGAMVYGELGSLLPHAGGDYVYLKQAYGPVAAFLSGWASFTIGFGAAVAASSISFSSYALQVVPVDDETGWIARGLSLSLLWLVTFMHCRGVGTGGRLQLLLTTTKVAAIGGLILGGLWTIGEWGHLTERPARAEPSLGASAVALVIITYCYMGWNVAGYIASDIADPRRALPRIMIGGTAFVAAVYLLLNMVYLSALSMAELAREPIVPVAEKTAAALWGTGGGRFVSGILCLSIAGAVSAMTWAGPRVYWAMARDGIVSPWLAALRPATGAPARAIVTQSLWASLLIMSGTFEQLLVYSGLVLSLFLALTLSSVFRLRSRIPAGPDTYRVPWYPLLPAVLVSGASFLVFYSLLQRPSESLFGAATIAAGIPFYWWWNTTRSRPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2J9</accession>
    <name>A0A1W1I2J9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47240">
        <property type="protein sequence ID" value="SLM47240"/>
        <property type="gene ID" value="NSJP_1068"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1068"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="64" mass="7221" checksum="BBBB5C0EDB88C791" modified="2017-06-07" version="1">MASQQNPDNAATIIQLRAVIMNTSLLNARLLDQPWAGRNARLTARLRTTYYVSIVVRPASLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2N7</accession>
    <name>A0A1W1I2N7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Universal stress protein UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1063"/>
    <dbReference type="EnsemblBacteria" id="SLM47235">
        <property type="protein sequence ID" value="SLM47235"/>
        <property type="gene ID" value="NSJP_1063"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1063"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="152"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="288" mass="31276" checksum="16BB5FAF1639CE18" modified="2017-06-07" version="1">MNIVVAMDGSKFGRQALNWAAALPLKDRPRVTALHVLDIDALRAPFVAQSMVAGNQRFIQQEVRRMERRAAETLAEARRQMRTLRLNGKAKELRGGVAPTILKEAPGTHGMIVVGSQGLDALDRLMLGSVSTNVLHHASRPVLIVKAGVRTVRRIVLAADGSTSSRHAMKWLLTKLRPTVSSSGDATRTPIHVTVVHVMPFLRYPELKEAGSRLAEECRRKLLDAGFGADSVCRLGRPADEIVKVAVDRRADLIIMGAQGLGAIARLVLGSVSTRVAQRSSISVLVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Q0</accession>
    <name>A0A1W1I2Q0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47274">
        <property type="protein sequence ID" value="SLM47274"/>
        <property type="gene ID" value="NSJP_1102"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1102"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013026307" evidence="1">
        <location>
            <begin position="36"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="163" mass="17314" checksum="BE5FDFAEE228D797" modified="2017-06-07" version="1">MKVRVGSRKSLMRCLCGGAVALAAVGTAAVPAAQAADPEMKIEVTISDKGYNVKGHTMPGSLTAIVVRNEGSMTHGISSPLFKSGVVKKEGAGVEIRGEKGKGFRAYHLEPGQTMTLYFQKETHPDPGTGISETMQVPFWCDIHQHMKGEFLVVETRGEVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2T9</accession>
    <name>A0A1W1I2T9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1146"/>
    <dbReference type="EnsemblBacteria" id="SLM47318">
        <property type="protein sequence ID" value="SLM47318"/>
        <property type="gene ID" value="NSJP_1146"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1146"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="218" mass="22992" checksum="C54418A1400309B5" modified="2017-06-07" version="1">MRFVAAAIDFDGTLAMDGKVAPSTLAAVEQLLSSGRKFIIVTGRLLQELLDLFPQAVLCSRIVAENGALLYHPATREQRLLGGAVPGPLVEVLRRKDIPFQQGEAILATVRPHEVAALETIRDLGLAHHVVFNRGSVMILPPGVTKASGLQAALDDLQLSAHNVVGIGDSENDHALLQAAELAVAVSGAVPTLREAADVVTPEDNGRGTAWFFSALVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2V3</accession>
    <name>A0A1W1I2V3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47153">
        <property type="protein sequence ID" value="SLM47153"/>
        <property type="gene ID" value="NSJP_0981"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0981"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012280522" evidence="1">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="80" mass="8907" checksum="F762F2EE012FBF1D" modified="2017-06-07" version="1">MRRTIDSTGGLAAAMLLFVTLSAAGCTGDKPKELLETAEFEERQMNLPHAKQLYEELVRQYPTSPEANTARARLAKLNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2V8</accession>
    <name>A0A1W1I2V8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47305">
        <property type="protein sequence ID" value="SLM47305"/>
        <property type="gene ID" value="NSJP_1133"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1133"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01361">
        <property type="entry name" value="UPF0391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009760">
        <property type="entry name" value="DUF1328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07043">
        <property type="entry name" value="DUF1328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036466">
        <property type="entry name" value="UCP036466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="55" mass="5784" checksum="7F9E407A0461B93A" modified="2017-06-07" version="1">MLSWAVTFLVVAIIAGLLGLSGVAGTATQIAYVLFIVFLIFAAVSFLMGRRPPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2Y9</accession>
    <name>A0A1W1I2Y9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47335">
        <property type="protein sequence ID" value="SLM47335"/>
        <property type="gene ID" value="NSJP_1163"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1163"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="2">
        <location>
            <begin position="22"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="175" mass="19839" checksum="089A70A02A3DE9CB" modified="2017-06-07" version="1">MRHDTSDKTQEQDVEETTDVFESLKADHRMVKEWFAKFEEADKPTKSSIAEDTLAALEVHTAIEEELVYPAIAEVIDDEDGIKEAIEEHHVAKLLIKELRRMKPGEDAFATKFKVLGELVSHHIEEEEGEMFPQAEEAGIDTESLSRDVMKRKAALMRRHGGGKKSSAPRRRKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I358</accession>
    <name>A0A1W1I358_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47432">
        <property type="protein sequence ID" value="SLM47432"/>
        <property type="gene ID" value="NSJP_1260"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1260"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="28" mass="3130" checksum="1FA632AA759B53E9" modified="2017-06-07" version="1">MGFAIELFCTLTTVLTPGFYRPNSAYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I364</accession>
    <name>A0A1W1I364_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47273">
        <property type="protein sequence ID" value="SLM47273"/>
        <property type="gene ID" value="NSJP_1101"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1101"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="125" mass="13747" checksum="264CCAFD66FEE3E7" modified="2017-06-07" version="1">MVKTVIPARNPGSPTSILRPCLHREIGHISPLADCRRRRQQRTDTDPKQAASSYDTAIKDSFYAGLRQGVCKCGLNGAKRYSGISVARMKLQTGTEPERWPDRCESDPEVQSTQGGRYEGPGGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I367</accession>
    <name>A0A1W1I367_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47442">
        <property type="protein sequence ID" value="SLM47442"/>
        <property type="gene ID" value="NSJP_1270"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1270"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="63" mass="7051" checksum="412D3510069FFE57" modified="2017-06-07" version="1">MQQLAVGVEKLLVCIAHNFHCRAQLLAKSAITRMGWSLLPHRVTQKTTTIMGALWRGPLLKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I368</accession>
    <name>A0A1W1I368_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1262"/>
    <dbReference type="EnsemblBacteria" id="SLM47434">
        <property type="protein sequence ID" value="SLM47434"/>
        <property type="gene ID" value="NSJP_1262"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1262"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="573" mass="65207" checksum="FE6DB8EA3E526B83" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3H8</accession>
    <name>A0A1W1I3H8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1386"/>
    <dbReference type="EnsemblBacteria" id="SLM47558">
        <property type="protein sequence ID" value="SLM47558"/>
        <property type="gene ID" value="NSJP_1386"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1386"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021878">
        <property type="entry name" value="TgpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11992">
        <property type="entry name" value="TgpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="453"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="730" mass="80606" checksum="840978C26B270ED5" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3J8</accession>
    <name>A0A1W1I3J8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease P protein component</fullName>
            <shortName evidence="5">RNase P protein</shortName>
            <shortName evidence="5">RNaseP protein</shortName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rnpA</name>
        <name evidence="6" type="ORF">NSJP_1406</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RnpA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1406"/>
    <dbReference type="EnsemblBacteria" id="SLM47578">
        <property type="protein sequence ID" value="SLM47578"/>
        <property type="gene ID" value="NSJP_1406"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1406"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="126" mass="14917" checksum="C3D07382B2E8393F" modified="2017-06-07" version="1">MTGIRRERRERFLRASRDINYVKQHGRRLSTSLFNLLICKIEGTKTRVGIVVGRRFGPAVRRNRAKRLFRELTRHASEHLVEGYALLVFPKREVLELPFERLRAIWCSTLSRQRLFRSEAEASRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3W3</accession>
    <name>A0A1W1I3W3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-alanine-D-alanine ligase</fullName>
            <ecNumber evidence="5">6.3.2.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ddlA</name>
        <name evidence="5" type="ORF">NSJP_1520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.2.4" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1520"/>
    <dbReference type="EnsemblBacteria" id="SLM47692">
        <property type="protein sequence ID" value="SLM47692"/>
        <property type="gene ID" value="NSJP_1520"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1520"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="117"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="340" mass="38994" checksum="255510C2A2BD377D" modified="2017-06-07" version="1">MRRLRILVLMHEDLVPPEHLTGQDVKSVQWKTEYDVVSTLRKLGHDVRPLGVKSDLGAIRTAVDEWKPHIAFNLLEEFDGVAVYDQNVVSYLELLRVPYTGCNPRGLMLARDKVLSKKLFSFHRIPFPDFTVVPLGRSVKRPNWLSFPLIVKSVTEEASLGISQASIVEDDEKLKERVAFIHNSLETAALIERYIEGREFYVGVTGNGHLHVFPVWELRMDRLPEEARRIATERVKWSRKYQEKYGITSREARNLPGGKAEEIQHLAKRVYRALGLSGYARIDMRMDEVGRLYVLEANPNPQIAQDEDFADSAGKADYQYKDLLQELLSVGLRWRPTKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3W6</accession>
    <name>A0A1W1I3W6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47665">
        <property type="protein sequence ID" value="SLM47665"/>
        <property type="gene ID" value="NSJP_1493"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1493"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="94" mass="10808" checksum="BFA88140AE856220" modified="2017-06-07" version="1">MNREMLIKLWQAHKNDEWPHVETGQEGPLMTLDTVISGCVVYVLDGEEDLDEQRRAIVSDCLAELDTLEIEINDECRSYFGRLREIGTLLLITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I497</accession>
    <name>A0A1W1I497_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine protease Do</fullName>
            <ecNumber evidence="8">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">degP</name>
        <name evidence="8" type="ORF">NSJP_1666</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.-" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1666"/>
    <dbReference type="EnsemblBacteria" id="SLM47838">
        <property type="protein sequence ID" value="SLM47838"/>
        <property type="gene ID" value="NSJP_1666"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1666"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011782">
        <property type="entry name" value="Pept_S1C_Do"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02037">
        <property type="entry name" value="degP_htrA_DO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012144915" evidence="6">
        <location>
            <begin position="28"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="255"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="403"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR611782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM47838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="471" mass="49532" checksum="A174292888DDF312" modified="2017-06-07" version="1">MVQSAIGWFCAAVCVLMPALSMNEARAGSRLVAVSGASDLQQQIKDTAAKVIPAVVSIASTVMVKDQAFTDETLPFGLFKDPPARRQYGQGSGVIVSPDGYIVTNHHVVADAVDVEVVLADRRQYKGKVVATDPRTDVAVVKIQATNLPTVPWGDSGRLAVGDFVLAIGNPLGLSRTATFGIVSAVGRADVGVADFEDFIQTDAPINPGNSGGALVNIRGELIGINTAIASPTGGSVGVGFAIPSNMARAAMQSLIKTGRVVRGFLGASTQDVSPTLGKIFHLPDVKGAIVTDLQPKGSAEKAGLKRGDVIERFDGHDVMDSGHLRNLVAAVPIGSKHRLDVIRDGKAVQMELVVQEAPKDRPKRSQSAVAEAAVSQHPLSGVVFDDVTPPLARQMDLPVNSGVVVTDMEEGSLAESSGLQPGDVILELNRQPIPNFATFQRLADPMKPTDLALLLVNRQGTVLYIPVRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4C0</accession>
    <name>A0A1W1I4C0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5666 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47850">
        <property type="protein sequence ID" value="SLM47850"/>
        <property type="gene ID" value="NSJP_1678"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1678"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043724">
        <property type="entry name" value="DUF5666"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18914">
        <property type="entry name" value="DUF5666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013343135" description="DUF5666 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5666" evidence="2">
        <location>
            <begin position="29"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="113" mass="12007" checksum="613A3D0F98352F06" modified="2017-06-07" version="1">MVRYLFMATLVLFCSATAFAHGSGQHVLGTVTEIDRDHIQVKTQKGGTVTVKVTKDTHFKEKGNPNSSELPAAGDRVVIDAVKEKKGLTATEVHFSPAKKAAAATVPAPQPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4E0</accession>
    <name>A0A1W1I4E0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_1702</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1702"/>
    <dbReference type="EnsemblBacteria" id="SLM47874">
        <property type="protein sequence ID" value="SLM47874"/>
        <property type="gene ID" value="NSJP_1702"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1702"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003826">
        <property type="entry name" value="AdoMetDC_fam_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02675">
        <property type="entry name" value="AdoMet_dc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="SSF56276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <keyword evidence="4" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM47874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="147" mass="16038" checksum="15486437F280C923" modified="2017-06-07" version="1">MSVTVGSESTILPSSAPTTSSPVQAHEMVGEGKAWGLCTAVDLQDCQPDLIRNAEHIRRYVVELCELIGMKRFGECQVVDFGSGRVAGYSMVQLISTSLISGHFANDTNNAYLDIFSCKGYDPAVVEAFSKDFFKARRSTATVTLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4I8</accession>
    <name>A0A1W1I4I8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="8">CMK</shortName>
            <ecNumber evidence="2 8">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">ispE</name>
        <name evidence="11" type="ORF">NSJP_1752</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="2 8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1752"/>
    <dbReference type="EnsemblBacteria" id="SLM47924">
        <property type="protein sequence ID" value="SLM47924"/>
        <property type="gene ID" value="NSJP_1752"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1752"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="PTHR43527:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="9">
        <location>
            <begin position="100"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="10">
        <location>
            <begin position="222"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM47924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="307" mass="33070" checksum="F7FFE1A23A43F90F" modified="2017-06-07" version="1">MTNRASVSEPTGLSSVVTVSAPAKINLILRILDRRPDGYHNVWSIMQTVALVDEVRLRLSHTGQVRLRCDSSELSGDHNNLVHKAAVAVLERAGTAVGLDIELKKMIPLGAGLGGGSSDAAATIVGLNRLLRLEWSQMEMRNIAQTLGSDVPFFLFAPSAVVAGRGEAVKPVAVQNARWAVLVNPGFGVETRWAYHELATSRQGVRPLSDRQRRLDEQTQVDWPQLKAAAENDFESPVFAKHPALGAIKQTLLSRGAEIALLSGSGATVFGLYGDEQSARRAQTEFLSDSRLKTFVVPTCSGPLIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4N9</accession>
    <name>A0A1W1I4N9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47966">
        <property type="protein sequence ID" value="SLM47966"/>
        <property type="gene ID" value="NSJP_1794"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1794"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="60" mass="6875" checksum="5E42E3A7BA917262" modified="2017-06-07" version="1">MVDKPKKSEDPEPESQPKARKEIPLISVPNDRDMIAEEMEELFDEDRVSHQHGSSEPEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4P7</accession>
    <name>A0A1W1I4P7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YfiO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1825"/>
    <dbReference type="EnsemblBacteria" id="SLM47997">
        <property type="protein sequence ID" value="SLM47997"/>
        <property type="gene ID" value="NSJP_1825"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1825"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017689">
        <property type="entry name" value="BamD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039565">
        <property type="entry name" value="BamD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13525">
        <property type="entry name" value="YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03302">
        <property type="entry name" value="OM_YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="YfiO" evidence="3">
        <location>
            <begin position="63"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="312" mass="34128" checksum="52BA7B8A53275242" modified="2017-06-07" version="1">MRRFGNNFRAVAGDGRRFILPVIVLGLLMGCSSSHKSGDQASKKALSGTDESIFLGDTIEKNYDPNVIMKRGEAFFEKEEYAEAIVEYNHFLDLHRSHQLASYAAFRIGESQMKRAKGIERDPEPVQKAIESFDRLRRDYPGSRYDGQAVQKVQECHDLLAQMHLFVGQFYYRRGSYLAAAHRFEQIMQLYPDKSVAPDALYFLALSYHEMGADDWASDKLTLLAQKYPNAGHSRDGAKLLAKIGPSKSDTVVAKKPASASPSPDGTGSAASDGSSILANGLSSSPSAGSVQIPSASSLTGSFVNCRLGAWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Z0</accession>
    <name>A0A1W1I4Z0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1890"/>
    <dbReference type="EnsemblBacteria" id="SLM48062">
        <property type="protein sequence ID" value="SLM48062"/>
        <property type="gene ID" value="NSJP_1890"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1890"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_15" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="137" mass="15901" checksum="766028829975849A" modified="2017-06-07" version="1">MRIKNIAIKNFRSIKDANLLFPENNLLILVGANNAGKSNIVRTVNNILGPEWWTHEKLQARDHYGHDTDNQISIKLSFDTQDIISFKWHYQQSQYKLFGNGSFLTNELKGQFPCTYLGADRTFDRQCHSTIGHCWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I509</accession>
    <name>A0A1W1I509_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48107">
        <property type="protein sequence ID" value="SLM48107"/>
        <property type="gene ID" value="NSJP_1935"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1935"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="55" mass="5974" checksum="AF0AEF58550554D6" modified="2017-06-07" version="1">MQPTINYPKNCGHQACRCLAREHSSYCSEACEQALAAPPGARCSCVHTECTDRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I521</accession>
    <name>A0A1W1I521_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48092">
        <property type="protein sequence ID" value="SLM48092"/>
        <property type="gene ID" value="NSJP_1920"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1920"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="98" mass="11207" checksum="42D205BF8C463BBB" modified="2017-06-07" version="1">MDRHPQDFLNPLTSAQAHAELFREHHPEYADAMLKFLLELARITNDLKNALGYKKFCAVCRIPMESKLDMNGKRQGNLLWLEGWSCPTCGGEQVSCQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I525</accession>
    <name>A0A1W1I525_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48114">
        <property type="protein sequence ID" value="SLM48114"/>
        <property type="gene ID" value="NSJP_1942"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1942"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="534" mass="59461" checksum="E4D0CA5E6F4309C3" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5C6</accession>
    <name>A0A1W1I5C6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2042"/>
    <dbReference type="EnsemblBacteria" id="SLM48214">
        <property type="protein sequence ID" value="SLM48214"/>
        <property type="gene ID" value="NSJP_2042"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2042"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012732212" evidence="2">
        <location>
            <begin position="23"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="505" mass="55588" checksum="8DA9D29BE02FE70F" modified="2017-06-07" version="1">MWTRAILGVLVIASLPVFQASAENMTPEDIKKLVDEAVEKRMREIEKHERSTLPEGVERPEVIRSEGPRDQPGIGPLPEVGRERRTESQPALSFGSTGSGRLVYAKPFVAAPKAIVGGYMDIQFRSQQKASIEAGDGRPGITNNFDQQRFVPFFYADVTEHVKFAAELEIEHGIRESSENEIETGLEFAHIDYLVKESFNLRAGILLLPVGKFNLLHDSPLNDLTDRPLVAQFIVPTTMSETGAGFYGTFYPGRTGKIDYEFYFTTGPCGYGADGTPLVSEQEGTRDGRQRTCSGHDGADINNGKAVVGRLAYSPMLGMEVAGSTYFGNANNNSSNYNPLNITAIDWTFQRGPFELIGEAAWSYARGNSRAVQGNTIGFAPGTVLTGIPGNSGQGTPTQRGMGYYIQGNYHFMPSFLTKLSPKRFGEGSTFTAVIRYDRVNTNLDNTNGTGGWGNLEQISFGLNYRPIEDAVFKMSYQYQPMAFNPVTQQRIHDNAFVISAATYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5D0</accession>
    <name>A0A1W1I5D0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_2028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in formation and maintenance of cell shape.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MreC family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2028"/>
    <dbReference type="EnsemblBacteria" id="SLM48200">
        <property type="protein sequence ID" value="SLM48200"/>
        <property type="gene ID" value="NSJP_2028"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2028"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038471">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00219">
        <property type="entry name" value="mreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="291" mass="31520" checksum="D6E095837F6E2B4A" modified="2017-06-07" version="1">MWMATLRVPYNARRLALGGFALLLLVLFLFPAQSQSVLQYLDGPVGQVVRIPLEVVVSIDEGISGVWHRYIALQGIQEENEQLRQDIEWLKGQNNQLREAAAATERLTALLHFKEQALPTLVAAQVIGRDATSWYRSVILNKGESDGIKPDMGVITPAGVVGRIVKTNSATSVVLLVTDPNNAIAGLIQRTRDEGIVEGTQQGLAKLKYIPMLSSVRSGDRVVTSGLVGGFPRGLALGTISRIDKEEGALFQSAELTPEVDVSRLEEVLVIQAPYGVSVQGDDKNVSMGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5E8</accession>
    <name>A0A1W1I5E8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxygen sensor histidine kinase NreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NSJP_2062</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2062"/>
    <dbReference type="EnsemblBacteria" id="SLM48234">
        <property type="protein sequence ID" value="SLM48234"/>
        <property type="gene ID" value="NSJP_2062"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2062"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="14">
        <location>
            <begin position="150"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="15">
        <location>
            <begin position="228"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="297"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="101"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SLM48234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="501" mass="55824" checksum="B0DF07742D50386E" modified="2017-06-07" version="1">MINEWWRIGAILLLIAGLFVLDILTPLGFADHFLYALVVVIAIGSRIRWLMSATAVLSTALTVLAVFLSSSTPELPLWIPIGNCAFTIIIIWVVVWFALKRRQAEAALQKANERLEEKVVERTRQLAGVNEALVSEVTERMQTEQAFRLSEGRLAGILDIAQDAIILIEEDRSISLFNQGASRLFGYSPEEVLGRPVELLLPARYRIHHPSNVQAFAFGPESARPMAERREVFGLRKDGREFPAEASISKLTIAEKTTFTVILRDITDRQQTEQQLQSLTAQLMTAQEEERRRISRELHDDINQRLAILAIELGNMETEPALSGEQSRQAIQSLAQRLATISDDVRRIAYQFHSSILDDLGLPAALTQLTDEFSARTGVKTIVVQEELTQPFPRDVASCLYRITQESLANVSRHATASRVELELTCDGSAVTLSIQDNGKGFDPAQHRHRRGLGLINMRERVRAIQGRMEIHSQTGQGTRISVLVPLPGVTADEETSNPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Q7</accession>
    <name>A0A1W1I5Q7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2037"/>
    <dbReference type="EnsemblBacteria" id="SLM48209">
        <property type="protein sequence ID" value="SLM48209"/>
        <property type="gene ID" value="NSJP_2037"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2037"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="636" mass="68686" checksum="26F74F5B75F646FD" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5V3</accession>
    <name>A0A1W1I5V3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2077"/>
    <dbReference type="EnsemblBacteria" id="SLM48249">
        <property type="protein sequence ID" value="SLM48249"/>
        <property type="gene ID" value="NSJP_2077"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2077"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="171" mass="19824" checksum="766208B2EDD8D420" modified="2017-06-07" version="1">MDVQDFLTQGDGREEDKREAWCLFQQAYERQMKNELEEAVSLYRQSLSVHPTAEAHTFLGWTYSFMGRLDDAIDECRMAIARDPDFGNPYNDIGAYLIEKGQFDEAIPWFQKAMQARRYESPAFPHLNLGRVYEKKGQWTDAIEAYKQALLLNPDYVLAKKSLGRLISSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5V8</accession>
    <name>A0A1W1I5V8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Ferrochelatase</fullName>
            <ecNumber evidence="7 8">4.99.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Heme synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Protoheme ferro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">hemH</name>
        <name evidence="9" type="ORF">NSJP_2193</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2 H(+) + heme b = Fe(2+) + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.99.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:49572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="4.99.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:49574"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.1" evidence="7 8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2193"/>
    <dbReference type="EnsemblBacteria" id="SLM48365">
        <property type="protein sequence ID" value="SLM48365"/>
        <property type="gene ID" value="NSJP_2193"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2193"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="PTHR11108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="2 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="315" mass="35024" checksum="736FC011211BF2B7" modified="2017-06-07" version="1">MNDAQRPIAVLLMAMGGPDKLENVEPFLLDVRRGRPTPPELVEEIRERYRATGGKSPAVDITQSVAARLERRLNESRARYRVFVGLRHWHPFIRDTYAELLREEPEHVIGLCMAPQQSSLSTGAYRKKVEEARLALGGTCPVSYVGSWHQHPRLINAIADHIQQALARFPLETRPSIPVLFTAHSLPERIVAMNDPYPDEVRGTVEAVTAQLGGQPTGFAYQSQGRSGEKWLGPTVESRIHELGAAGHRHVLVAPIGFLCDHVETLYDIDIELRQLAAGLGMRLERMPMLNDSLALVETLMDVLAAHESSLTLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Y9</accession>
    <name>A0A1W1I5Y9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Transporter, eamA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2189"/>
    <dbReference type="EnsemblBacteria" id="SLM48361">
        <property type="protein sequence ID" value="SLM48361"/>
        <property type="gene ID" value="NSJP_2189"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2189"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="4"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="137"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="289" mass="30746" checksum="436A841FD1AB0AEF" modified="2017-06-07" version="1">MPRLALLLTTLIWGATFPATKAALEQIPPLSFLFLRFFLGTVLVAGWFAAAGHGLRYDRGMLRAAAIATGFLFLGYLLQTVGLRYTSASNSAFLTALYVVIVPLILRRFDRRIILATSVATVGLWLLVKPSTTMSVGDLMTLACAAAFAAHIVCLERFSRLFDAPSLLLWQMTAMTLLFIPAMWWEDAPVEAFAPTAVLLIGLGVTGGLATGAFAVQMWAQQLVPAQQVALVFASEPAYAAWLSWYFLGETLDAQGWLGSGLILLAVVVGALASGASADAERGGAAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6B0</accession>
    <name>A0A1W1I6B0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RNA polymerase, sigma-54 (Sigma N) factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rpoN</name>
        <name evidence="12" type="ORF">NSJP_2370</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-54 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2370"/>
    <dbReference type="EnsemblBacteria" id="SLM48542">
        <property type="protein sequence ID" value="SLM48542"/>
        <property type="gene ID" value="NSJP_2370"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2370"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000394">
        <property type="entry name" value="RNA_pol_sigma_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007046">
        <property type="entry name" value="RNA_pol_sigma_54_core-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007634">
        <property type="entry name" value="RNA_pol_sigma_54_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038709">
        <property type="entry name" value="RpoN_core-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32248">
        <property type="entry name" value="PTHR32248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00309">
        <property type="entry name" value="Sigma54_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04963">
        <property type="entry name" value="Sigma54_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04552">
        <property type="entry name" value="Sigma54_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000774">
        <property type="entry name" value="RpoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00045">
        <property type="entry name" value="SIGMA54FCT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02395">
        <property type="entry name" value="rpoN_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00717">
        <property type="entry name" value="SIGMA54_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00718">
        <property type="entry name" value="SIGMA54_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma54_CBD" evidence="11">
        <location>
            <begin position="129"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma54_DBD" evidence="10">
        <location>
            <begin position="345"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="55"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM48542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="507" mass="56965" checksum="6ACEF2301582DB11" modified="2017-06-07" version="1">MSMKLRLDLKLSQKLIMTPQLQQAIKLLQLSRLELQQSLVQHLMDNPMLDELPAEAEENEGSSADEQGEDAAASASSNSETAESEESTPEERDTPDEASAAGWEEYFQTDRRTGSGERQSSSSDDFPSYEQNMRKATSLEDHLLWQLSLSGLSEQQKVIGRLLIGNLDDDGYLRMPLSEVISGTEFAEAEVESVLKDIQTFDPTGVGARDLPECLLLQLGHLGRSPIGSLGARPGALKGSIIEAIILHHLKDLEKKQYARVAKALDVTIEEVLQATKVIEGLEPKPGRPFDNTQNYVIVPDVFVVKNEGEWVVLLNDDGLPRMRISPYYKQLMASGQSGSTETKAYLDERLRAAQWVIRSIEQRNKTIVKVVSSIVKFQEQFFEHGVQYLKPLVLKQVAEDIGMHESTISRVTANKYMYCPQGMLELKFFFNAGLQRADQPSDMLSSVTVREMIRKMVAAEDARHPLKDEEIAARLREQQVLIARRTVAKYRAEENIPPATQRKQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6B6</accession>
    <name>A0A1W1I6B6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rplF</name>
        <name evidence="7" type="ORF">NSJP_2353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2353"/>
    <dbReference type="EnsemblBacteria" id="SLM48525">
        <property type="protein sequence ID" value="SLM48525"/>
        <property type="gene ID" value="NSJP_2353"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2353"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="91"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="178" mass="19023" checksum="6C99E7EA871E8D8C" modified="2017-06-07" version="1">MSRIGKKPVPVPSGVDVKVAGSVVSVKGPLGKLDWALAPGIGVTVDQGQVLITRSSEARNVRALHGLVRAELSNMVLGVTKGYERNLEITGVGYKAAVQGRTMSFNVGYINPVVYPIPAGIEVKIDKQTLINVKGIDKRLVGQVAANLRAIKPPDVYKQKGVRYVGEVLRKKEGKTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6E2</accession>
    <name>A0A1W1I6E2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrate transport ATP-binding subunits C and D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_2405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2405"/>
    <dbReference type="EnsemblBacteria" id="SLM48577">
        <property type="protein sequence ID" value="SLM48577"/>
        <property type="gene ID" value="NSJP_2405"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2405"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005890">
        <property type="entry name" value="NO3_transporter_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01184">
        <property type="entry name" value="ntrCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="288" mass="31542" checksum="DED23AE34B963133" modified="2017-06-07" version="1">MAFLQIDHVSKFFPNPSGAGQVCIFRDATIKIDKGEFVTVIGHSGCGKSTLLNIIAGLETPSEGGVILNGREASGPGLDRMVVFQNFALMPWMTVFENIALAVRSAYPEWTAAQVSAHVTRYIALVGLKGAENKRPAALSGGMKQRVGLARAFSIEPKVLLLDEPFAQIDALTRGVIQEELIQMWNTSRNTVFMVTHDVDEAILLSDRILLMTNGPEARIAEMVHVSIARPRSRETVIDHPHYYKIRNHIIHFLVRHAKHGGHYGTGHQAESGDPVVVNFDEATVSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6J3</accession>
    <name>A0A1W1I6J3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2454"/>
    <dbReference type="EnsemblBacteria" id="SLM48626">
        <property type="protein sequence ID" value="SLM48626"/>
        <property type="gene ID" value="NSJP_2454"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2454"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="151" mass="16538" checksum="50B3E352439DF005" modified="2017-06-07" version="1">MSRQPFITADLRPDVSEDDAEQAHVGGSAGTEQLAEAARALLSEEERQQVERGDQGKRQELMASIPRASTNVQGTTLDGETVLLDFTSGRYYTLNRVGSAVWEHCTGSESLQDIHEGLCARYDAAPERIADDLLALVTQLGHEGLLTLERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6L0</accession>
    <name>A0A1W1I6L0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48646">
        <property type="protein sequence ID" value="SLM48646"/>
        <property type="gene ID" value="NSJP_2474"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2474"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="332" mass="35772" checksum="9C232EF45F45DAED" modified="2017-06-07" version="1">MVQPVVHDVGWVRLLAGTLIVGVLGVAEAFTLTEPTEQALLRSGARVAVSVQVGTDVNIRAIRYYWYRLDEEPVDAHQTLPAPFRTADGDAPLSGYVEVPTEANGAMRLLAIGELTRGRLGTAEDFDEVIVQVRPDAPLGAIEFSVQRPWRFDTIGKRMSVPVVGQYDDGVSRPLTGPSSGSRFTSSDDAVVTVDEGGILTVTGNGRAQVTVENQGKIGTIQVVVNGDPSPNRPPIAAVERELQVRSDHLVVLDGLGSRDPDGDPLRYEWRQLRGPRVALSSVDEAKATFMAPKVTERKLFQFSLTVIDMAGPDRVKGAESAPAVISVWVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6R4</accession>
    <name>A0A1W1I6R4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2535"/>
    <dbReference type="EnsemblBacteria" id="SLM48702">
        <property type="protein sequence ID" value="SLM48702"/>
        <property type="gene ID" value="NSJP_2535"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2535"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="89"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="265" mass="30964" checksum="A226A54D4AE105DD" modified="2017-06-07" version="1">MCRLLALERQTLRYRSRRYEDEALRTRIREIAEAKRRYGCPRIYIRLRRAGWRVNHKKVERIYYRDEGLSVRRRRRKKFAAVPRVTLPQPADPGRCYALDFVHDRLVTGRRYKCLTMTDPCSKEVPVIEVDVSIGGARVCRILDRVFLTRPLPETLILDNGPEFAGTALDAWAAQHGVHLHFIQPGKPVQNAFIESFNGKFRDECLNEHWFVTLQEAQVVIEAWRREYNEDRTHRASGDVTPQEFITNYQNQAQPTQALTSSALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6X0</accession>
    <name>A0A1W1I6X0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48671">
        <property type="protein sequence ID" value="SLM48671"/>
        <property type="gene ID" value="NSJP_2499"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2499"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007890">
        <property type="entry name" value="CHASE2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05226">
        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01080">
        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="CHASE2" evidence="2">
        <location>
            <begin position="58"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="523" mass="58177" checksum="360F3DC665213BC0" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6X3</accession>
    <name>A0A1W1I6X3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48766">
        <property type="protein sequence ID" value="SLM48766"/>
        <property type="gene ID" value="NSJP_2599"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2599"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="128" mass="14322" checksum="8BA90C5AB12203F9" modified="2017-06-07" version="1">MSYNLKVIPISEFLRSDVTGVVDLKASRELLKGLIEICAKENLDRILIDGREASSSASTVDVWTLANDLGTLGLSRDYRVAVLNRPKDDFDRMAFLELCATNRGYQLRAFRGFEEAFTWLTAGDEVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6X8</accession>
    <name>A0A1W1I6X8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 3-demethylubiquinone-9 3-O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.64</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.64" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2605"/>
    <dbReference type="EnsemblBacteria" id="SLM48772">
        <property type="protein sequence ID" value="SLM48772"/>
        <property type="gene ID" value="NSJP_2605"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2605"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008689">
        <property type="term" value="F:3-demethylubiquinone-9 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009725">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021700">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="161" mass="18079" checksum="4FD95668CC3D8978" modified="2017-06-07" version="1">MQRITPCLWFDDQAEDAAKFYVSVFKNSRMGPITRYGGAGANVSGRPKGSVMTVTFHIEGQEFVALNGGPLFKFSEAISLMVKCRSQHEIDEMWAKLSEGGQEGPCGWLKDQYGLSWQIVVPAWDEMLRDANPEKSERVMAAILQMSKPDMQQVQHAYDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I741</accession>
    <name>A0A1W1I741_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxA</name>
        <name evidence="6" type="ORF">NSJP_2653</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2653"/>
    <dbReference type="EnsemblBacteria" id="SLM48820">
        <property type="protein sequence ID" value="SLM48820"/>
        <property type="gene ID" value="NSJP_2653"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2653"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="33"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="115" mass="12769" checksum="0665CBBCF526B6FF" modified="2017-06-07" version="1">MAGDALKVEDATWEADVIKASELVMVDFWAVWCGPCQMVAPIVDELAKEYSGKIKVRKLNTDENPEVAGRYQVMSIPTILFFKNGQVVEKLVGARPKRQFKEMIDSLLAQHAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I745</accession>
    <name>A0A1W1I745_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thaumatin pathogenesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2574"/>
    <dbReference type="EnsemblBacteria" id="SLM48741">
        <property type="protein sequence ID" value="SLM48741"/>
        <property type="gene ID" value="NSJP_2574"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2574"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="SSF49870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="583" mass="61397" checksum="1A2BCBE47B23026C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7B1</accession>
    <name>A0A1W1I7B1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48890">
        <property type="protein sequence ID" value="SLM48890"/>
        <property type="gene ID" value="NSJP_2723"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2723"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012348149" evidence="1">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="108" mass="11675" checksum="61BA2013B538CE7E" modified="2017-06-07" version="1">MRQWFRAICPVLLLCVAGAVAAGCGHEASLTRETETGGVVTFPIESEGDVLSSAGRRDALRLIANKCPNGSRIVKEGEIPKVSKSADRNWRGQMGTERIWGIQFTCGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7G0</accession>
    <name>A0A1W1I7G0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein ArsC</fullName>
            <ecNumber evidence="2">1.20.4.-</ecNumber>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arsC</name>
        <name evidence="2" type="ORF">NSJP_2694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.20.4.-" evidence="2"/>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48861">
        <property type="protein sequence ID" value="SLM48861"/>
        <property type="gene ID" value="NSJP_2694"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2694"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="157" mass="17521" checksum="39C9D8F24EB3E591" modified="2017-06-07" version="1">MKPRILFLCTGNSARSQMAEALLTLIAGDHFDVASAGTHPVGVHPMTVAVMKELGVERSGYRSKSVQEFIGQQFDYVITVCDRAKETCPIFPSASRLLHWSFDDPASVTEAVRREAFVRVRDEIADRICRFCLQEMRLSPAALTCYCCVTDTTDRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7M4</accession>
    <name>A0A1W1I7M4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2818"/>
    <dbReference type="EnsemblBacteria" id="SLM48985">
        <property type="protein sequence ID" value="SLM48985"/>
        <property type="gene ID" value="NSJP_2818"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2818"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="139" mass="15193" checksum="339DFAC4CEDC7C1F" modified="2017-06-07" version="1">MTQKPRFVIFAHNAMYDNLHQVATLGLTAAAMGKDVTIVLLFWTIRKLAEGRIDEMDFSPEHGIVGDQVRSLLKGKKIPTISEMFQDARLFGSFKLVACSAGLEYMGVDAEAVTTRVDDVMGLPAILTLTAGAETTLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7V1</accession>
    <name>A0A1W1I7V1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">phoU</name>
        <name evidence="3" type="ORF">NSJP_2716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2716"/>
    <dbReference type="EnsemblBacteria" id="SLM48883">
        <property type="protein sequence ID" value="SLM48883"/>
        <property type="gene ID" value="NSJP_2716"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2716"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="120"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="227" mass="25865" checksum="B85D930C16C0D973" modified="2017-06-07" version="1">MMHRHFDQELADLKTQILRMGSLVEQQIEGSIQALVDRDVHLASRIIERDALVNGLDVEIDETCIRLLALQAPAAGDLRFITTAMKISTELERMSDLAENISERVIELNEEPQLKPYIDIPRMSSWTMRMVRECLEAFVRSDATLARKVCADDDFVDDLTHQLFRELLSFMLENPGTITRAIRLTFIGKYLERIADHATNVGELVIYMVEGKIIRHTSQPVRADNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Y3</accession>
    <name>A0A1W1I7Y3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49158">
        <property type="protein sequence ID" value="SLM49158"/>
        <property type="gene ID" value="NSJP_2991"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2991"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="66" mass="7450" checksum="94FC709CC1E34938" modified="2017-06-07" version="1">MTLDDARKRIESAVTQYGQHAAPVLDLVMNEVRSDMGAKAFNQLVEEFDLELEYNIAPLESDYSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Z1</accession>
    <name>A0A1W1I7Z1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="2">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="2">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2953"/>
    <dbReference type="EnsemblBacteria" id="SLM49120">
        <property type="protein sequence ID" value="SLM49120"/>
        <property type="gene ID" value="NSJP_2953"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2953"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014051">
        <property type="entry name" value="Phosphoesterase_HXTX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02834">
        <property type="entry name" value="LigT_PEase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="112"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 1" evidence="2">
        <location>
            <begin position="48"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="2">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="201" mass="22600" checksum="893020117930D254" modified="2017-06-07" version="1">MIRAFLAVVPDAELLRRLALVQQDLKQRLMRDLPRTVRLSWVQPASIHLTLKFLGDIPEDLVPVLNDAMIQTMSGHRSLSIPLERLGAFPDARRPRILWAGPGTSWEESEDSRRLAAMHEAIEMCCRTVDLAPDSRALTPHLTLARVREGDRYLGSQLTRNGELNNPIRPGAFEVGAVVLMRSELHPTGSVYTPLWDVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I832</accession>
    <name>A0A1W1I832_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Multidrug resistance protein NorM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2978"/>
    <dbReference type="EnsemblBacteria" id="SLM49145">
        <property type="protein sequence ID" value="SLM49145"/>
        <property type="gene ID" value="NSJP_2978"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2978"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="337"/>
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        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="441" mass="47430" checksum="5142655B1FF6556B" modified="2017-06-07" version="1">MADGVTQIRRSVLTLALPVTVSSLLQRAEGIVAVFLVGGLGAESIAAVGLGQLLAFIATTLVSGISVGANVITAQMWGARRHRDVGQAARHFLWLSVAVSLALTGSGLLLNGRAMGLLGVEPDVIRLALPYSTLIFILIPFSVLLQVLSAILQGTGNTKTPMYAMIGVNLIHVAIAYPLIYGRWNFPAMGINGAAIAVGFAEAAGTAYLLYRCRPLLHGPTRIRPELLRALWRVGAPVSGERIVQQTGILVYTKIVLLYGTVAYAAHQVGLSIESLSFLPGYGFAVAAATMVGQSIGAGKYTRAKLENWEANRLASLVMAVMGAVFFFFPYVLLRAFTNDESVIALGTVFLKIVALLQVPLALTMVLAGSLRGAGDTHFIMVATTIGMWAVRVPVAIVAGLWLQLEVLYVWLAMIADWTLRMGLMVWRYRSERWKAIQVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I872</accession>
    <name>A0A1W1I872_9BACT</name>
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        </submittedName>
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                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
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        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="SLM49222.1"/>
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    </dbReference>
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        <property type="gene ID" value="NSJP_3055"/>
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        <property type="component" value="Chromosome i"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49222.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="104" mass="11576" checksum="835799B9D03D1A97" modified="2017-06-07" version="1">MLLKLFLFSVLGIATVSDIGRAGDLGSMPKDLDAQSEQLPPTELEQVVALCAKQIHNESASSKFDAYVQRGVVESFGTDQERFRFRKCMAQREHPLGPSLHEKK</sequence>
</entry>
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    <accession>A0A1W1I891</accession>
    <name>A0A1W1I891_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49079">
        <property type="protein sequence ID" value="SLM49079"/>
        <property type="gene ID" value="NSJP_2912"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2912"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="60" mass="6106" checksum="EB8F74AF71F5CF8F" modified="2017-06-07" version="1">MVLFVHVRTGPGAVTDEGTESKGASAEGTGSDKDRGCVYSPSSNRRDRLGPPDIGGGRGS</sequence>
</entry>
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    <accession>A0A1W1I8E2</accession>
    <name>A0A1W1I8E2_9BACT</name>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49191">
        <property type="protein sequence ID" value="SLM49191"/>
        <property type="gene ID" value="NSJP_3024"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3024"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="35" mass="3776" checksum="05D7A1FE37BE0341" modified="2017-06-07" version="1">MLAPRDSVYLAQCMGVFPRKDPSAAPAVVSRKSLN</sequence>
</entry>
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    <accession>A0A1W1I8W0</accession>
    <name>A0A1W1I8W0_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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            <authorList>
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                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49425">
        <property type="protein sequence ID" value="SLM49425"/>
        <property type="gene ID" value="NSJP_3258"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3258"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="38" mass="3966" checksum="92A829A42EDA85AF" modified="2017-06-07" version="1">MHGADGVSRPSLRTDPLLTGVADEQNNSGRALELVMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Z8</accession>
    <name>A0A1W1I8Z8_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="SLM49508"/>
        <property type="gene ID" value="NSJP_3341"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3341"/>
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        <property type="component" value="Chromosome i"/>
    </dbReference>
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        <property type="entry name" value="DUF5132"/>
    </dbReference>
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        <property type="entry name" value="DUF5132"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="52"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="101" mass="10849" checksum="EC4A19971B4FDCF0" modified="2017-06-07" version="1">MADILSGIGATLRPLAKELIKGGIYLFDTVSEVALEAGEKFKDIVAEARADLAQQSSQPPAEEASAKAEASPVEEANGEVEKNGDQSRRRRKTRVPIRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9A7</accession>
    <name>A0A1W1I9A7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit omega</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rpoZ</name>
        <name evidence="9" type="ORF">NSJP_3419</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3419"/>
    <dbReference type="EnsemblBacteria" id="SLM49586">
        <property type="protein sequence ID" value="SLM49586"/>
        <property type="gene ID" value="NSJP_3419"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3419"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="119" mass="13497" checksum="F37530B2206C90C4" modified="2017-06-07" version="1">MIEMLNLLPQYTPDQFDSRHRLVIVAAQRAKHILQGSRPFGASRFTKETTVALDEVLRGEAKYLMGKEARDAMKEAKRGKEGESERMAMMTGEDAREIKKELSVYVDDTPKAPEPEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9B9</accession>
    <name>A0A1W1I9B9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">efp</name>
        <name evidence="11" type="ORF">NSJP_3415</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3415"/>
    <dbReference type="EnsemblBacteria" id="SLM49582">
        <property type="protein sequence ID" value="SLM49582"/>
        <property type="gene ID" value="NSJP_3415"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3415"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM49582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="186" mass="21004" checksum="D65758F39649DCFD" modified="2017-06-07" version="1">MISTTDFRGGVRLLLDGEPFYIVEFQHVKPGKGGAFVRTKLKSYISGNVLDRTFRSGERFEEPDLEERDMQFLYATGDDYTFMDTESYEQLTFAKKQLGDNADLLKENMVAKILIYEHRPIDVELPIFIELKVVDAEPGVRGDTASGGTKPAVVETGATIKVPLYLEVGTVIKIDTRTRAYVERVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9D0</accession>
    <name>A0A1W1I9D0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Negative regulator of genetic competence ClpC/MecB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">clpC</name>
        <name evidence="10" type="ORF">NSJP_3425</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3425"/>
    <dbReference type="EnsemblBacteria" id="SLM49592">
        <property type="protein sequence ID" value="SLM49592"/>
        <property type="gene ID" value="NSJP_3425"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3425"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="9">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="8">
        <location>
            <begin position="414"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="410"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM49592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="808" mass="91631" checksum="3FDC5C3B87C05E16" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9G0</accession>
    <name>A0A1W1I9G0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3455"/>
    <dbReference type="EnsemblBacteria" id="SLM49622">
        <property type="protein sequence ID" value="SLM49622"/>
        <property type="gene ID" value="NSJP_3455"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3455"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="219" mass="25076" checksum="17321229E36C9AA9" modified="2017-06-07" version="1">MTTLSQYLSRTQLLQERCRGRRVLHLGCSSGQYLKDRLMRGSLLHWMLRDEAGELHGVDLDGKSLDTMREMGFRHLHEGNAEELEKLDLKETFDIVLAGDLLEHITKPGSMLEGVRRFLKPTGSFIVSTNNAFGLHYQLRRWSGQYVEHVEHVCFYSPETLLHLFERHGYDIAEMYGAYTEPPYSWKQKVKFAIGQPLFKLVPVLAGTIIVVATPKIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9M1</accession>
    <name>A0A1W1I9M1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49696">
        <property type="protein sequence ID" value="SLM49696"/>
        <property type="gene ID" value="NSJP_3529"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3529"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="57" mass="6260" checksum="D165711B590E80E7" modified="2017-06-07" version="1">MCDDVCGLSSGIFPRVHFYLPHGTDASKASATLFPMSDVGAVLGDHFLPDWHHFVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9P1</accession>
    <name>A0A1W1I9P1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49712">
        <property type="protein sequence ID" value="SLM49712"/>
        <property type="gene ID" value="NSJP_3545"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3545"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025774">
        <property type="entry name" value="MTs_g-TMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51581">
        <property type="entry name" value="SAM_GTMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_11" evidence="3">
        <location>
            <begin position="111"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif I" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif II" evidence="1">
        <location>
            <begin position="170"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif III" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="345" mass="38545" checksum="B72A6FB8B839B4B4" modified="2017-06-07" version="1">MDVNDITLLETFDMMNMFILVIVSLLVLLLIGLVLYLLFPRKYHSADSVANSYDDWTNDGILEFYWGEHIHLGHYGSPPHKKDFLKAKSDFVHEMARWGGLDKLPAGTTVLDVGCGIGGSSRILARDYGFAVTGITLSPQQVRRAQELTSPEVNAHFQVDDALALSFPDASFDVVWSVEAGPHMPDKARFARELLRVLKPGGILVVADWNQRDDRRVPLNFWEKPVMRQLLDQWSHPAFSSIERFSELLEETGLVAGEVTTADWTAETLPSWVDSIWQGAVRPAGLVRFGMVGVIKSLREVPTFLLMRLAFGTGLCRFGMFRAVHANVPASEILSTQTGNRCVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Q6</accession>
    <name>A0A1W1I9Q6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vitamin B12 import system, permease protein BtuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">btuC</name>
        <name evidence="8" type="ORF">NSJP_3555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3555"/>
    <dbReference type="EnsemblBacteria" id="SLM49722">
        <property type="protein sequence ID" value="SLM49722"/>
        <property type="gene ID" value="NSJP_3555"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3555"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="384" mass="40538" checksum="33B52FFCFF7D27A9" modified="2017-06-07" version="1">MMSPSDHSSPSASVGLPPPVPEPKTAPAAFADDEVFRKSTLGAGRWTAVIGMLLVLAALLALLCLQFGTQFVGLNEMARIFARMVEATSDRRSESDVMATILLQVRLPRIFLGFLVGGCLAAVGVALQALLRNPLADPYVLGVSSGAALGVSVAVLFGVGTTVMAMSALPLCGFAGSVVALALMYRMAASYDRLPIHSVLLAGVILNAIFSALIMFITSIMDPNRSFGMMIWLMGSLMAPAYPTLLVFSLYAAVCLTLLFGQVNVLNVMAYGEEPARSLGVDTELAKRRILLFSALMTGAVVSVSGMVGFIGMVIPHAVRLMVGADHRLVMPASALIGGTFLMVADTFARTVVSPSELPVGIMTALVGGPFFVYLLAWRKDRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Y4</accession>
    <name>A0A1W1I9Y4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Catalase-related peroxidase</fullName>
            <ecNumber evidence="1">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has an organic peroxide-dependent peroxidase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3700"/>
    <dbReference type="EnsemblBacteria" id="SLM49867">
        <property type="protein sequence ID" value="SLM49867"/>
        <property type="gene ID" value="NSJP_3700"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3700"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08153">
        <property type="entry name" value="srpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024168">
        <property type="entry name" value="Catalase_SrpA-type_pred"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000296">
        <property type="entry name" value="SrpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0349">Heme</keyword>
    <keyword evidence="1 3" id="KW-0408">Iron</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012845476" description="Catalase-related peroxidase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Catalase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000296-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000296-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="334" mass="35493" checksum="98846C96571DD3A5" modified="2017-06-07" version="1">MRTTCVATAALAAVLALPASGFAEETSAAQVSLPEQLVNAFNAVFGAHPGLRANHPKGVVLEGSFTPSDKAASVSKAAHFAKQAKPIPVTVRFSAGSGLPTVPDTNEMPRGMAIKFSLPDGSQTDMVVLSYNGFPVSTGEDFRDFLLAIAASGPDAPKPNALENFLNGHPAAKTFVQTPKPPPVSYGTLPYFGINAFKFTNAKGKTALVRYQLQPITGVQYLTKEQVSAKGPDYLSDEIRDRVRRAPVKFHLLAQVAEPGDKTDDPTVVWPETRRTIDLGTLTIVKAVEDSQAAEKKLLFVPGALTPGIEAADPMIAVRSAAYIVSLSRRAQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Y8</accession>
    <name>A0A1W1I9Y8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49816">
        <property type="protein sequence ID" value="SLM49816"/>
        <property type="gene ID" value="NSJP_3649"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3649"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="87" mass="9348" checksum="E4D1F27A520C09CC" modified="2017-06-07" version="1">MLTAVQAASGSALAVGILVSPGSDRTAARMHPKVSLFSIRAPLVVNHVVQTGEEDCLGRVLGPRKFHNGFRSRPRPKPSDLHLTLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Z2</accession>
    <name>A0A1W1I9Z2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49868">
        <property type="protein sequence ID" value="SLM49868"/>
        <property type="gene ID" value="NSJP_3701"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3701"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="225" mass="24698" checksum="475BCAA1771E2CE8" modified="2017-06-07" version="1">MNRETTHTPPIRLWLLFIILLLHGCSSKGTPTGVHFPVTSGSHRLLPAAEQSILLWGAPDVTHVAVEWLRSHHYTHVVVADENRVREAKDAPPGSDRKAALTLGENMHAEFVLLLDRETNKEGTLIEPHCGARFFVEVTLRGLSVNNGETVLQARAHYPQCVELSGRIARSLTCQTFATAWGFRPSGQLDLPSHLMCTAGQTAPMANRPAGEIPNERRALPGDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA06</accession>
    <name>A0A1W1IA06_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49830">
        <property type="protein sequence ID" value="SLM49830"/>
        <property type="gene ID" value="NSJP_3663"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3663"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="139" mass="15811" checksum="E96A1D794B009F80" modified="2017-06-07" version="1">MATTTQMLRGHRGQEAPTRNILADQRIAFPFISRLIHVHNGHTKRPHCLKSRRHSFRLPRMRKRYTPSEWMRATEQDPGLRGLSPADAATRLNITEQEVGELVLSGTLNVSDICEDGEVVNVVIPERDIKRYAAQSKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAA2</accession>
    <name>A0A1W1IAA2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Chemotaxis protein CheW (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3526"/>
    <dbReference type="EnsemblBacteria" id="SLM49693">
        <property type="protein sequence ID" value="SLM49693"/>
        <property type="gene ID" value="NSJP_3526"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3526"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="33"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="173" mass="18233" checksum="B348901D10BFCDE5" modified="2017-06-07" version="1">MSTSSSTNTSQGQPLAGILPAGSAAAQPAGSPSVRAAIISLGGEMFTVDLQHVREVFVVESVTPVPGMPSGLVGVTNLRGTVIPLLDLRQMFGLGTEATLRYAVVLKHGAWQVGVLVDSVPEIRTLSRDQFMPAPRDTGREANPFVSAVVKLEDRLRGVLETSAVLSHFESAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAF5</accession>
    <name>A0A1W1IAF5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50038">
        <property type="protein sequence ID" value="SLM50038"/>
        <property type="gene ID" value="NSJP_3871"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3871"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012484090" evidence="1">
        <location>
            <begin position="26"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="113" mass="11619" checksum="B9F97E149A9A2F89" modified="2017-06-07" version="1">MRGMTCAIVLVGVLAVNGAASAVLAGDEDGSKVTITAPADGASVDGASVDLKYELAKGVKAHHAHVYLDGQYQKGFKGTFTNLAPGKHEIKVVAATDDHKMLAAESVVTIEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAI0</accession>
    <name>A0A1W1IAI0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49995">
        <property type="protein sequence ID" value="SLM49995"/>
        <property type="gene ID" value="NSJP_3828"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3828"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="67" mass="7401" checksum="3E750CE11DF71D76" modified="2017-06-07" version="1">MLNQPSEFKQGPKVWILAFLLLALLIAAYVVFEDWISGPSYPPRSPVVPIPRQHPNEPAPPAPSTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB04</accession>
    <name>A0A1W1IB04_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Low calcium response locus protein S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lcrS</name>
        <name evidence="1" type="ORF">NSJP_4015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4015"/>
    <dbReference type="EnsemblBacteria" id="SLM50182">
        <property type="protein sequence ID" value="SLM50182"/>
        <property type="gene ID" value="NSJP_4015"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4015"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="88" mass="10215" checksum="76C01926BEA5EC2B" modified="2017-06-07" version="1">MRQSKFTDTQIVSILKEADAGRPVNEIWRQYGISSATYYKWKAKYGGLEASDVKRLKELEHENNRLKRMYADLSLEHAALKDVIAKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB18</accession>
    <name>A0A1W1IB18_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ferrichrome iron receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fhuA</name>
        <name evidence="10" type="ORF">NSJP_3944</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3944"/>
    <dbReference type="EnsemblBacteria" id="SLM50111">
        <property type="protein sequence ID" value="SLM50111"/>
        <property type="gene ID" value="NSJP_3944"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3944"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030148">
        <property type="entry name" value="Fiu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF68">
        <property type="entry name" value="PTHR32552:SF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07660">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0798">TonB box</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="STN" evidence="9">
        <location>
            <begin position="79"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM50111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="867" mass="94708" checksum="0C03B072B1D8A828" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB22</accession>
    <name>A0A1W1IB22_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50214">
        <property type="protein sequence ID" value="SLM50214"/>
        <property type="gene ID" value="NSJP_4047"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4047"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="381" mass="43788" checksum="7D0F8DFB90CDD355" modified="2017-06-07" version="1">MIGKVLRRLSPSLKTVVIVMLPILSVVFVLAAAEVVFRLYQRWDYGIPIRASLEQEDWNPAWSLVLDDTLGWRARAGYYDEVTETTSHGKRYPVTRSQHDYGFRMFGDLRSGKPTILVIGDSFTQASQVSDGDTYFAIIKRELNAEIFAYGAGGFGTLQEYMILDRYVDMIHPSLILWQFCLNDFINNDPALEMASSMNNNGWRRPYWVDGRIEYLLPKTWTGSLRMWAQRYSRFFHWTFSRWDRLLAMHPGKTVEDDIAKEGLSHKGFQHAMRVTGELVRKTRLRVGDVPIVAFSCWKAEPYDTAFKMISDQSDIVFFPDIAGEVRAAYERGEDVFHIDMGHWSVEGHRLAGLLISDHLRTLFPKLFQRPPASSAPSTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB31</accession>
    <name>A0A1W1IB31_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50121">
        <property type="protein sequence ID" value="SLM50121"/>
        <property type="gene ID" value="NSJP_3954"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3954"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="135" mass="14498" checksum="4483BB0BB36A992A" modified="2017-06-07" version="1">MSKMRHRGLPVPLLLHPGESLTYLEPSTHNPRKAQVGGRNSLKKISWHDVASRVVAASVGGYAMTYAVTICVTVLLPLSRTEAVLSAAMMSFLFYVGAIIWAFAAATPMRAWLGLLLSAGVSGLIAFPLVMAMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB53</accession>
    <name>A0A1W1IB53_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TonB_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_3962</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3962"/>
    <dbReference type="EnsemblBacteria" id="SLM50129">
        <property type="protein sequence ID" value="SLM50129"/>
        <property type="gene ID" value="NSJP_3962"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3962"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TonB_C" evidence="10">
        <location>
            <begin position="181"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM50129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="259" mass="28235" checksum="82D61D629258F57D" modified="2017-06-07" version="1">MVEAPPQVEPTPVTPPTPTPTPKPTPTPVQPRTTPQVQRTVDQRPQVETQTQQVQNVETVQQTVQDVATPVEQTTATPVETTVHHTAVQSVESPAAVTQTATPTVSAVVETNAPVAETAPVMEQVSVAQQPSVVQREAPVQSDAPAVEQRAVQHRVVQYKQTQADYGWLRDTLWKRIQELKRYPALARSNHWEGKVVIAAVIREDGTVVGLRIAESSGRPILDQEALSVMRQASPLALKHPLGKPQVTILVPISYRLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBE8</accession>
    <name>A0A1W1IBE8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_4138</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4138"/>
    <dbReference type="EnsemblBacteria" id="SLM50305">
        <property type="protein sequence ID" value="SLM50305"/>
        <property type="gene ID" value="NSJP_4138"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4138"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="331"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM50305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="484" mass="52965" checksum="A3AF2603792743DC" modified="2017-06-07" version="1">MLTSLGKDVVLYGASDLLFKVLAFSVFPIYAYTFSVRDFGVIELVTAFSMLLTICCSLGLNNAVQRYYWDSDLTEEGKRRLVSTGLLFQSGSTIAVVAAAAICLYAVRQPIEEQYGMSWPLILFALAGLVPSVALQYVLDVLRLQFVPWRYACVAFLKNAVGVGAGLVLILAFGFGVTGIFMGTAVAGLLAVPVGLWLIGKDLEFDFNSGVAQTLFQFGYPFIFSGLAYWALGSIDRWMIAQFSNMDEVGLYGIAFKFAAVVMFLNTAFGQAWSPWAMKVRADRPDYRKVYSEVFSIWFLLLTLAGCALSLFAKELLILTTPERYWPAANILIVAVLGVVFLGTTQITAVGISLEKRTRIFAVSAWVGAALNVALNLVLIPRLGALGAALATTVTYFALSGSYLYWTQRVHPLPLNWTQLLSVFVVGLLSVPVAWTLNGFDTGLRTVLVKVLVMIIPIFLMWRGGLFRETLAAIVPPTGTPVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZL6</accession>
    <name>A0A1W1HZL6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 15" type="primary">lon</name>
        <name evidence="15" type="ORF">NSJP_0024</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0024"/>
    <dbReference type="EnsemblBacteria" id="SLM46196">
        <property type="protein sequence ID" value="SLM46196"/>
        <property type="gene ID" value="NSJP_0024"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0024"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
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        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
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        <property type="entry name" value="PUA-like_sf"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
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    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="14">
        <location>
            <begin position="21"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="13">
        <location>
            <begin position="604"/>
            <end position="785"/>
        </location>
    </feature>
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        <location>
            <begin position="786"/>
            <end position="835"/>
        </location>
    </feature>
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            <begin position="249"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="794"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="691"/>
        </location>
    </feature>
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        </location>
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    <feature type="binding site" evidence="5 8">
        <location>
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            <end position="375"/>
        </location>
        <ligand>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
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            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="835" mass="93090" checksum="AA3C968D8B17F5DC" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZN5</accession>
    <name>A0A1W1HZN5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Outer membrane protein assembly factor YaeT</fullName>
        </submittedName>
    </protein>
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    <organism evidence="6 7">
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="SLM46194.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="769" mass="86389" checksum="72F6E2D563142A04" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZQ2</accession>
    <name>A0A1W1HZQ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
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    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="88" mass="9527" checksum="481E1D24BEF9F456" modified="2017-06-07" version="1">MIVRKSPWVLLIFLLIGGLLGGILGEILRVMAPQGTIQAVFATNFTPGISPPLTIDLILIKLTLGFSLKISLLSLLGMFLGVYLYKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZU2</accession>
    <name>A0A1W1HZU2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46265">
        <property type="protein sequence ID" value="SLM46265"/>
        <property type="gene ID" value="NSJP_0093"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0093"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
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        <property type="entry name" value="DUF192"/>
    </dbReference>
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        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR37953"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="150" mass="17398" checksum="A4800FB320BADCE5" modified="2017-06-07" version="1">MRTHWLLVALFGWLVLHPAVTKADDRLVQIRLPNGTIIHAEVADTQRKRAEGLMFREHLPRDRGMLFTFEQAQAWTFWMKNTKIPLDIIWMNEKKQVIHIAHNVPTCTRTDDGCPQYQPNDPALYVLELGSGEAERLKIERGAKLQFQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I064</accession>
    <name>A0A1W1I064_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
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            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0202"/>
    <dbReference type="EnsemblBacteria" id="SLM46374">
        <property type="protein sequence ID" value="SLM46374"/>
        <property type="gene ID" value="NSJP_0202"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0202"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="143" mass="16208" checksum="153DDAFBEDA1823F" modified="2017-06-07" version="1">MALSSHHRTLPPTIIHRQALLDLRRGLLGLHKALIIAEQLTYERINGRVASTGQLLQLVLNDPWFTWLHPLSQLVIRVDELLDADSDLTSAEVDELVLEVRRLIRPSEEGDGFERSYYEALQRAPDVIFAHVEVKKLLTKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I095</accession>
    <name>A0A1W1I095_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Glycosyl transferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0244"/>
    <dbReference type="EnsemblBacteria" id="SLM46416">
        <property type="protein sequence ID" value="SLM46416"/>
        <property type="gene ID" value="NSJP_0244"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0244"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="361" mass="41549" checksum="0B261BF087B80615" modified="2017-06-07" version="1">MPPKVSVVMSVYQGEQYLEEALRGVLNQTWRDYEFIIVDDGSTDDTALILNNHAERDRRIKLLKNEHNLGLTKSLNRALSIVQGEYVARQDADDVSMRRRLESQVKLMESRPQVGLVGTACRVIDAEGRALGDYVWPTSDTAIRWHMLFHNAFCHSSVMWRRSAFGEHEPRYDEGYRYSQDYALWTVLLRSAKAENLEVPLVAYRSHDRNIEATSRAAQQDSADNIAAQAIDELLGDELINRENLRTLRQWYNRWPDRLVASDRHVCALYLRILSAFVRVHSSRSGDMAEICRSVVERVLSSLTGSSPIELWRAGLAGTLLQLDGPFVMKFMGRGYWKRMKSLLRPVVRPAINERDTRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0J0</accession>
    <name>A0A1W1I0J0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug efflux system, subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mdtB</name>
        <name evidence="2" type="ORF">NSJP_0322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0322"/>
    <dbReference type="EnsemblBacteria" id="SLM46494">
        <property type="protein sequence ID" value="SLM46494"/>
        <property type="gene ID" value="NSJP_0322"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0322"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="858"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="909"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="954"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1038" mass="111915" checksum="600E6477EC111095" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0P7</accession>
    <name>A0A1W1I0P7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46449">
        <property type="protein sequence ID" value="SLM46449"/>
        <property type="gene ID" value="NSJP_0277"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0277"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="97" mass="10766" checksum="0D2184A9FDD99026" modified="2017-06-07" version="1">MKEEVTMNRSMMLLSALLLTLPGCESHTWPLRYPNSAVADAKQGEDCRYLVFGMGHMPDMSGTKAMRLGSITMLRSTEYQVNTLQGVGRECIIAHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I180</accession>
    <name>A0A1W1I180_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0586"/>
    <dbReference type="EnsemblBacteria" id="SLM46758">
        <property type="protein sequence ID" value="SLM46758"/>
        <property type="gene ID" value="NSJP_0586"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0586"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021890">
        <property type="entry name" value="DUF3501"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12007">
        <property type="entry name" value="DUF3501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="196" mass="22849" checksum="5FD1D0B216757EA3" modified="2017-06-07" version="1">MKRLIQEDLLSIEEYERQRERFRAGIIELKRRRRIALGPIITLVFENRETLKFQIQEMIRVERILDPRKVQDELDVYNELLPLPGELSATLLIEITEDARMKEWLDRFMGLDHGDKVAIGSGQEQAFGIFEGGHSHESKISAVHFVRFRPSDQLKRAFADLHQTVSLTVDHNGYRMDVPAPGTLREEWLSDLREGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I197</accession>
    <name>A0A1W1I197_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46778">
        <property type="protein sequence ID" value="SLM46778"/>
        <property type="gene ID" value="NSJP_0606"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0606"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="276" mass="31605" checksum="5CDBF49B3B6834A1" modified="2017-06-07" version="1">MAEFGDFIFSVFDHWLQLLGGCVLMVLVALFEKYVLQREVSIKVYTALLCLLVFWACFLAWKDQYELNKQAPDYRAEITTMQKHIGQKDSEIRDLKDFKTTATTELTILRHEKDTLIHDLEGKSNEVQILQNKLRLAETSSLPLVDLATPPILQGEKNGSLILFPLVNAGAAQITVVSTETTVYLGKDEFFEKNTNQFILHPNLRHHPFELPVDIPKITPQEIETGKTPLQVIVKLTMKGAFNEEHIGCLSWEWGEHEKKRRQGRPKECAKSYHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1B3</accession>
    <name>A0A1W1I1B3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46796">
        <property type="protein sequence ID" value="SLM46796"/>
        <property type="gene ID" value="NSJP_0624"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0624"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="200" mass="22582" checksum="0ACC64F1328B0D40" modified="2017-06-07" version="1">MSLKRADPCSRRTRICEPLPNRPATLEQIVAQYISAYRSRAQEALDRIPTGTPPASAVEIAVWAGKADHQRRLSPKSLSAFQKILLGKLHIIQNCANFDELHRSMEADRVHGVGKLAIYDIALLLGRYWGYLPERVYLHRGTRRGAKALSPLGVDHRCDSLTVTDFPTSFHALQPYEIEDCLCIYEDHIKRIVSHLALSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1N5</accession>
    <name>A0A1W1I1N5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Type IV pilus assembly protein PilB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0733"/>
    <dbReference type="EnsemblBacteria" id="SLM46905">
        <property type="protein sequence ID" value="SLM46905"/>
        <property type="gene ID" value="NSJP_0733"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0733"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="599" mass="66687" checksum="F099E714133AF748" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1S4</accession>
    <name>A0A1W1I1S4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46931">
        <property type="protein sequence ID" value="SLM46931"/>
        <property type="gene ID" value="NSJP_0759"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0759"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012461433" evidence="1">
        <location>
            <begin position="27"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="172" mass="18197" checksum="62D181E59A76D7AD" modified="2017-06-07" version="1">MKRVVLLAAVAVWSVLGLLTAEFAVAADAAGGPTGPTDNIVGGKPMKGEATKTLKGRVWSQWADNPDGELLFGIQYWNTGEPASGTPAGRSSTDLDVKPPDPLFTCCSWGFVGGADRNNPYSGWYHAATTVRLAVKDKALMDQIIKASQELVAMEVSLDGRTITGFKVIKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I211</accession>
    <name>A0A1W1I211_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47050">
        <property type="protein sequence ID" value="SLM47050"/>
        <property type="gene ID" value="NSJP_0878"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0878"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="67" mass="6820" checksum="188D19EADF60E733" modified="2017-06-07" version="1">MPSPTHTAPLAVRTSDAASRNPSGLSIRVPGVAHAGVGDHLDPHRPHLLVAGLVGHAGRIGARAHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I244</accession>
    <name>A0A1W1I244_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="12">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">kdpB</name>
        <name evidence="13" type="ORF">NSJP_0892</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="12"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0892"/>
    <dbReference type="EnsemblBacteria" id="SLM47064">
        <property type="protein sequence ID" value="SLM47064"/>
        <property type="gene ID" value="NSJP_0892"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0892"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02078">
        <property type="entry name" value="P-type_ATPase_K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
        <property type="entry name" value="KdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
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    </dbReference>
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        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01497">
        <property type="entry name" value="kdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="612"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="681"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="12">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="402"/>
            <end position="409"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM47064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="707" mass="75032" checksum="62F4E6031C681DB7" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I255</accession>
    <name>A0A1W1I255_9BACT</name>
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        <submittedName>
            <fullName evidence="4">Putative Peptidase M16</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0902"/>
    <dbReference type="EnsemblBacteria" id="SLM47074">
        <property type="protein sequence ID" value="SLM47074"/>
        <property type="gene ID" value="NSJP_0902"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0902"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012190341" evidence="1">
        <location>
            <begin position="34"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="74"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="221"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="490" mass="53411" checksum="19C57A22A631A189" modified="2017-06-07" version="1">MTRVNGVRSTMRWAGCALGAAAVAFLLPLIVAAGGDAPTADPRVMKFDPVEFTPPDPDRVVFENGMVVYLLEDHELPLITLSATLRTGAWLDPGEKVGLAALTGTVMRTGGGGTRSAEQVDQELEQFAGDVGIAIGRLSGSASLDVLNKDFKRGLDIFAGLIRSPSFEPARLELAKLQAIEGIRRRQDNPGSIVSREFLKQLYGSDHPSARESTVESIRRITRADLVAFHGKTVYPNGMILGVTGDFRRDDMLAMLRATFGDWKKGDVPDLKIPDARESTGSAPAIRFVGKETSQTHLRVGHLSIKETDPDYAALALANDILGGSSFRSRLFNDVRTKRGLAYSVGSRLTAGVHDQGIWLMRAETKLPSTQEVITRFVANLERIRTDVVSEEELAEAKEAYVNSFVFSFPNSAAVVNRLIELEYDGLPKDFLQQLRARVVALKREELLAAARKHLHPDRLTIVAVGPGGALPKMLSGFGDVKEIRLEPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2F6</accession>
    <name>A0A1W1I2F6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0877"/>
    <dbReference type="EnsemblBacteria" id="SLM47049">
        <property type="protein sequence ID" value="SLM47049"/>
        <property type="gene ID" value="NSJP_0877"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0877"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="102" mass="11661" checksum="002E3CFC5995D1B3" modified="2017-06-07" version="1">MKTSKTSVRRSGRSTRHAAHRLDRCLRVIRQLSAYLDDELPSDICRELRRHLGACPNCEVFVASLREAVGLCRHRPTPHLSPSERATLRREILRASRSGFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2J7</accession>
    <name>A0A1W1I2J7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative HAD-like hydrolase, purine nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0871"/>
    <dbReference type="EnsemblBacteria" id="SLM47043">
        <property type="protein sequence ID" value="SLM47043"/>
        <property type="gene ID" value="NSJP_0871"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0871"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="234" mass="26422" checksum="8C9BAD1F520FA51D" modified="2017-06-07" version="1">MDTLSSAEAPPRLDWSQIDDVLVDMDGTLLDRHFDNFFFEEELPRRYALRERLSLGESRARLMAMYRSVEDELAWTDLQYWTTRVGIDVVAMHRELDHMIGFLPGATAFLSAVRHHKKRLTVLTNAHPAGVAIKTAKTGLERQVDRIVDAFEVGYLKMRPQYWPACLELVGFDPAKALFIDDDERCLAAAKQFGIAHLLHSAKSSSQSPPAFSASFRSVEDLSSLLNGPEPAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2M8</accession>
    <name>A0A1W1I2M8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1072"/>
    <dbReference type="EnsemblBacteria" id="SLM47244">
        <property type="protein sequence ID" value="SLM47244"/>
        <property type="gene ID" value="NSJP_1072"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1072"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="156" mass="17204" checksum="41356F311EE50AB2" modified="2017-06-07" version="1">MRRHHELGSGKPSCRNDPALEAGDRRTDSRSTTGHDDLVHGRVTLTKIPHHKKSTNVAEALVVISLPGRHTISARKDNKTFEEAIRKAFEAVGIELRKFCDKRARKGVRSAPLPPLRGVVCKLFPLEDYGFILQEGGWRSVFPSKCAARAVVSGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2V9</accession>
    <name>A0A1W1I2V9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1166"/>
    <dbReference type="EnsemblBacteria" id="SLM47338">
        <property type="protein sequence ID" value="SLM47338"/>
        <property type="gene ID" value="NSJP_1166"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1166"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="116" mass="12829" checksum="29DF9DD4DCD9158B" modified="2017-06-07" version="1">MPLTSIQDLSRAKDFFEAKMAFTIGPVELERLMKSGEVNVVDVRAADDYAEGHIPGAINLPKEGWSAAQGLRTQGLPQRALLLFNRLPPGCHGSRRVRGPRFSRDGTRRRMALVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2W5</accession>
    <name>A0A1W1I2W5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1175"/>
    <dbReference type="EnsemblBacteria" id="SLM47347">
        <property type="protein sequence ID" value="SLM47347"/>
        <property type="gene ID" value="NSJP_1175"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1175"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="159"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="266" mass="29429" checksum="B0D2FD0B4FA1774F" modified="2017-06-07" version="1">MIHVDSINYTQPDTVGADSRTDNRILGSLGQTDRRLLCASMELVSLARGTILETTHEPTAYAYFPVQAVLSLFGTIGDGCKVEIGMIGQEGYLGMPIFSGQAVYRGHAMVQHAGTAWRMPAHLLDQAFHVSEPLRRRLLTYAAVCVSQFTQTAVCHRFHSLEQRLCRWLLAMHDRSGISEIRLTHEELAQAIGGRRPTINAITNNLKRAGAVASRRGSAIILQRQELERRTCECYGILARHIREAPLAQIPDPSPDRPAGEPGSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I301</accession>
    <name>A0A1W1I301_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_1087</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1087"/>
    <dbReference type="EnsemblBacteria" id="SLM47259">
        <property type="protein sequence ID" value="SLM47259"/>
        <property type="gene ID" value="NSJP_1087"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1087"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="50"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="125" mass="13140" checksum="53722188AC1C8A54" modified="2017-06-07" version="1">MSIDRASAVRVLSLYVMVMAILQGNVLQSSAGGPQDGSVQRGTIPSSPDGNAVRGKELYNVSCVVCHGKDAGGNIGPRLAGNAILANGQAFRKTVQEGRHMMPPLKDALTDEQIADILAWLKSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I325</accession>
    <name>A0A1W1I325_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47416">
        <property type="protein sequence ID" value="SLM47416"/>
        <property type="gene ID" value="NSJP_1244"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1244"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="101" mass="11197" checksum="69C4EF731A02EBAA" modified="2017-06-07" version="1">MTPSYMFPSSSCDPKNPSEPSSVIIWVRSQKGSDGGGLHLTEETMKLITRFEMVSKSTSELYALQRETFNALCARKPHSSEQRTCLASLANLEAEINSRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I328</accession>
    <name>A0A1W1I328_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Phage integrase family site-specific recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1236</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47408">
        <property type="protein sequence ID" value="SLM47408"/>
        <property type="gene ID" value="NSJP_1236"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1236"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="72"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="173"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="388" mass="43555" checksum="C163198491399821" modified="2017-06-07" version="1">MRGHLFQRNPEKNPRSWTIVLDVGRKVDPLTGRTKRVQMWKTVQGTKKEAQAELASMLHNLHRGQVVSPSKMTLSEWFDEWMKSAIKPNKRLRTCETYQNVIERHLKLALGQYRLGDLRASHIQHYYQSCKLAPATVSQHHTILHSALKAAVMQDLIPRNAASLVIGKPKRQTDHEDLTANCWDGPEAKAFLMAAKAGSAQDAAFYATALDGGARKAELCGLRWSDLDLEKKTLSIARQLVKIGKKDALPLFGPTKNGKARTVDLDERTIELLRRHKAQQAERRLLLGTSYQDHGLIFARDFGRPLPMNNLGERGFARLIKAAAIKRITFHGLRHTCATLLLQAGVPVKVVSERLGHKRIEITLNVYAHALPSMQQDAAVKLGRLLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I338</accession>
    <name>A0A1W1I338_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1246"/>
    <dbReference type="EnsemblBacteria" id="SLM47418">
        <property type="protein sequence ID" value="SLM47418"/>
        <property type="gene ID" value="NSJP_1246"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1246"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="314" mass="35706" checksum="CC61117F9B592903" modified="2017-06-07" version="1">MYHPYFRGKQYELITIREMASILQEADFCPIIEPVKETLNGLNRTLKAVAEVEGRAILIVNPHHGDLSESGKPLTELLQEEFLDLPGISAGILLKPNMSVTDALKCFENHSDHSPCFIHAGFTDAKTLSGRLDLSMKDQCHIFVDRFCGKLYQKHFKQATRILLRDGFQKKRNRDYEQLEFFSDLHATFEEEGMNGFGDFLIVGDDYSETGGPAYAVAIHLTFIDSDQDDAMQIYHFVSDRQDTPQDPAGKFAEALDKMISILNKRNSKVEETSAVQEFRELQHQGHFPGLGYIKKLSMNHHIETLARYFTPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I359</accession>
    <name>A0A1W1I359_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47438">
        <property type="protein sequence ID" value="SLM47438"/>
        <property type="gene ID" value="NSJP_1266"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1266"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="34" mass="3986" checksum="C582187BB4D4F078" modified="2017-06-07" version="1">MNYEFKLANDVVLQVKPGSKTQTFNWGLRNEKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I383</accession>
    <name>A0A1W1I383_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47293">
        <property type="protein sequence ID" value="SLM47293"/>
        <property type="gene ID" value="NSJP_1121"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1121"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="140" mass="15086" checksum="76F85DE2574A2307" modified="2017-06-07" version="1">MARAGIGLVLLAVVWTFQACGHSPLSDSRGVVRTIRISDVVKPTTVYARSGEEIRWENLRATPVRIGFLSVRLLEELGCKKGVSSFFGDIGDVITIAPGETASLCPIRSGTLQFNVWFDADNPKSEISPTATIHVEKTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I385</accession>
    <name>A0A1W1I385_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Hemolysin activation/secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1290"/>
    <dbReference type="EnsemblBacteria" id="SLM47462">
        <property type="protein sequence ID" value="SLM47462"/>
        <property type="gene ID" value="NSJP_1290"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1290"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005565">
        <property type="entry name" value="Hemolysn_activator_HlyB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013686">
        <property type="entry name" value="Polypept-transport_assoc_ShlB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08479">
        <property type="entry name" value="POTRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03865">
        <property type="entry name" value="ShlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POTRA_2" evidence="2">
        <location>
            <begin position="42"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="ShlB" evidence="1">
        <location>
            <begin position="177"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="535" mass="57699" checksum="AC17295FFC0E2DEA" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I392</accession>
    <name>A0A1W1I392_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Permease, MFS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_1177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47349">
        <property type="protein sequence ID" value="SLM47349"/>
        <property type="gene ID" value="NSJP_1177"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1177"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022324">
        <property type="entry name" value="Bacilysin_exporter_BacE_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01988">
        <property type="entry name" value="EXPORTERBACE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="22"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="425" mass="45287" checksum="238EAB3443576172" modified="2017-06-07" version="1">MRTSHRDRHKVDDRQHMLREPNVRWLYAGQLISQIGDGVSKVALLWFVYALTGSALKMTLIGVLQTLPPLLFGPFVGIIVDRVSKRTLMIVLDLARTVLLASIPALYAWGFLSLAGLYTLVFAVAMFAVAFGPALSSTLPLMVEEKQLTRINALMQSAMTIGQLLGPALSGLLIAAIGAQNALYVNAAAFFLSALCKLPLRLPSAAQSRRGRRAVAQILEDLREGVSFIFVRRRLLFLLMIIASVFSLGETSFVALLPLIGDRLLHVGPTTLGWLWSSLGLGIFASTLWLFWAKQPEVCVRLRLIAGAAAIGGVAVLALPQSGSTSLAAVLIAAVGAGSGLITPLISASLQERTARNLLGRVFGVFNTGTMAFAMIGMTLSGWLADGFGAVAALVAIGSIKLIAAGLSVTMIPWCRRLAASDPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3B3</accession>
    <name>A0A1W1I3B3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47507">
        <property type="protein sequence ID" value="SLM47507"/>
        <property type="gene ID" value="NSJP_1335"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1335"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012415903" evidence="1">
        <location>
            <begin position="29"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="371" mass="40627" checksum="D735CBDF30A01F45" modified="2017-06-07" version="1">MRVVSYVALTTASLLLCLVAPSSSPAYRDSFTAEQKAQLEKIQTVRVEVLMLSDKGPIEAAPIAELVAQRLSELGYQTVGDASKPNDVFFKVKCEQRKTWEGTTTAGGDADLPDAPSRLWKGPACQLTYVLGDMKIKWQKEVRASFEDSVSAAQATNAGDPAVFAMANLKEKLNQYDFPVLLAAEWGQLDRLLKLLDAPDTPQIRKLKIISLLGDMQADEALPKLKAALKDKDLSKQAAVALGNMGKEGIPVLVDILKHSKQPELQAAAAKGLGDLGNTHNDSSVVLPLLEMLDAPGVDITVQTEIAWALGRVPDRRSVQPLFELDKKLQKIRQDPVDPKMKKLKEAVFWAIKQVYTEDQYSSAETHSVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3I4</accession>
    <name>A0A1W1I3I4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1388"/>
    <dbReference type="EnsemblBacteria" id="SLM47560">
        <property type="protein sequence ID" value="SLM47560"/>
        <property type="gene ID" value="NSJP_1388"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1388"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="34"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="313" mass="34727" checksum="EB10A8D017E772FE" modified="2017-06-07" version="1">MNSSQTIQAIQDNIARVIKGKTQAIEMAVVCLLARGHLLLEDVPGVGKTTMAHSLARSLACSFKRIQFTSDLLPSDIVGVSIFNRQKQGFEFMPGPIFSNIVLADEINRTTPKTQSSLLEAMSEAQISVDNQTHPLQQPFMVIATQNPAEYHGTFPLPESQLDRFLMRLRLGYPSPEEERKVLDRPQALHPAEILDPVLSAEEVLTLQRRVDQIHMDDTLTDYLLAIVQATRHSELLSLGVSTRGALALSKTAKALACVRGRDYCLPDDIKELSPIVLSHRVMLNRAHGMRAHGFDQAERIILDIVDTIPVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3J0</accession>
    <name>A0A1W1I3J0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transporter subunit: ATP-binding component of ABC superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybbA</name>
        <name evidence="5" type="ORF">NSJP_1394</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1394"/>
    <dbReference type="EnsemblBacteria" id="SLM47566">
        <property type="protein sequence ID" value="SLM47566"/>
        <property type="gene ID" value="NSJP_1394"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1394"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM47566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="225" mass="24056" checksum="2C88FF52B8E829C3" modified="2017-06-07" version="1">MIDIAHVSMRLTAGGRPVDILHDVTLEIPTKQMVAIVGPSGSGKSTLLGLMAGLDRPTSGTIRLNGLDITRMKEAELARYRRAQIGYIFQSFHLIPTLTALENVLVPLELAGTSDAGARAAELLSAVGLGDRVHHYPVQLSGGEQQRVAVARAYACRPAALLADEPTGNLDSATGRHVMDLLLALQRDHGTTLVLVTHDASIASSMQRVITLRDGRVESDEIVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3N2</accession>
    <name>A0A1W1I3N2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anhydro-N-acetylmuramic acid kinase</fullName>
            <ecNumber evidence="1">2.7.1.170</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">AnhMurNAc kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">anmK</name>
        <name evidence="2" type="ORF">NSJP_1430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:24952"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58690"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.170"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan recycling.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anhydro-N-acetylmuramic acid kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.170" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1430"/>
    <dbReference type="EnsemblBacteria" id="SLM47602">
        <property type="protein sequence ID" value="SLM47602"/>
        <property type="gene ID" value="NSJP_1430"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1430"/>
    <dbReference type="UniPathway" id="UPA00343"/>
    <dbReference type="UniPathway" id="UPA00544"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097175">
        <property type="term" value="P:1,6-anhydro-N-acetyl-beta-muramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01270">
        <property type="entry name" value="AnhMurNAc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="PTHR30605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="388" mass="40940" checksum="697FBBC67EA36BAA" modified="2017-06-07" version="1">MKVIGLMSGTSGDGVDAALVEIAGRTPSLQVKTLAAETLAYPRTLQQRILTASVSGTVGEICHLNALLGEWFADAALQIIRAANLRPADVALIGSHGQTVHHLPRGIQARGVGSIRSTLQIAEPAVIAERTGITTIANFRARDVAAGGQGAPLTPAVHALLFRHPRRARLVVNLGGISNVTYVPPGKTDEGVMAFDTGPANMVLDSLVARMTNGRLAMDRDGKMALRGKADSRLLSKLLAHPFLSQRPPKSTGREQFGAALAEELLEAPHKLSMEDLLATCSAWTAKAVGASRRWIRGHIDEVVVGGGGVRNRAIMAQLSAVFAPVPVTTFDALGWDSKAFEAVAFAVLAYRTAKGQWGNLPAVTGATHPVILGAIVPAGPQWIRLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3U6</accession>
    <name>A0A1W1I3U6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47672">
        <property type="protein sequence ID" value="SLM47672"/>
        <property type="gene ID" value="NSJP_1500"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1500"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012890386" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="52" mass="5674" checksum="7ADAEE95A918F492" modified="2017-06-07" version="1">MMRALYAVLLGQLRYATSCMAVAGDGMGFPGTVLTEDHPRENWPSLAFRITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3V3</accession>
    <name>A0A1W1I3V3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47688">
        <property type="protein sequence ID" value="SLM47688"/>
        <property type="gene ID" value="NSJP_1516"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1516"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="144" mass="15958" checksum="1D32A0D54BE4E591" modified="2017-06-07" version="1">MPSFPDDRPDSGPPLWAMGLVVLLMIVTPLIIYSIAPSGPIREGDTIFSEGSITVPLAHPLLYDRARFDGSCLLDPEDPLMVITQPVERVDGLILAKVQGKTMIEWPFCPPQAEVLLTMQQITQKPALLGRAAQRVSDWLKLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3V9</accession>
    <name>A0A1W1I3V9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47696">
        <property type="protein sequence ID" value="SLM47696"/>
        <property type="gene ID" value="NSJP_1524"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1524"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="274" mass="31016" checksum="196930A9EE3E93C8" modified="2017-06-07" version="1">MNSIHSPGGNPDALETWWVALAERLCVADRARVFLSGVKSGNLLQRIEQVGGQVEYVLFVMVRYWVPTVLPPPGRERLTKNDPDYWLESEQILKTAAARLRELKPIIELLTTPHQQIDPAAASQGNPSPVMELELANVVEGLAEAAGTYGGPDYTSIVKAFDPVPLRQTQPFKHNKKHSAELWVVFLLREHFRSLGLGKDRYWPLIAPLCTAAGILNANGQAYGPDELKSWWQKNWPRTYTRLDQKQEAADSGGAAYEQDFAWFQGWIRWQQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3X7</accession>
    <name>A0A1W1I3X7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="8">HTPA synthase</shortName>
            <ecNumber evidence="4 8">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">dapA</name>
        <name evidence="10" type="ORF">NSJP_1532</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1532"/>
    <dbReference type="EnsemblBacteria" id="SLM47704">
        <property type="protein sequence ID" value="SLM47704"/>
        <property type="gene ID" value="NSJP_1532"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1532"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="8">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="8">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="8">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="290" mass="30857" checksum="962DC9B61EEE35F3" modified="2017-06-07" version="1">MFTGSLVAIVTPFKSGKVDEKAFGDLIEWQIASGTNGIVPCGTTGESATLSHEEHHRVVKLTVEVVRGRIPVIAGAGSNSTAEAISLTKHAKEAGADGALLITPYYNRPTQEGLYRHYKAIAEAVDLPQVLYNIPGRTGVNMLPATVARLCGMKNIVGIKEGSGSVQQASDIVMHCRERLTVLAGDDSLTLPMMAVGAKGVITVAANLVPSEMAKLVSTFLSGHLEESRGIHFRLSPLFAALFYETNPIPVKEALGLMGKMTPELRLPLCPMGTETKAQLTGVLKDLNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I400</accession>
    <name>A0A1W1I400_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AIRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1575"/>
    <dbReference type="EnsemblBacteria" id="SLM47747">
        <property type="protein sequence ID" value="SLM47747"/>
        <property type="gene ID" value="NSJP_1575"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1575"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039476">
        <property type="entry name" value="P2CMN_synthase_LarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43064">
        <property type="entry name" value="PTHR43064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="AIRC" evidence="2">
        <location>
            <begin position="118"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="258" mass="27370" checksum="D3D712D657FC057C" modified="2017-06-07" version="1">MTRQTLERMLERVRLGRLSVPQALDQLRSLPFEDLGFASLDHHRAIRQGFPEVILCEGKTPAQVRSIAKSLLKHHRPFLATRATPEVAAVITRLHRRALYHKDARVVAVRDPGVRPVGLVLVVTAGTSDVPVAEEAKITAETMGSRVETLYDVGVAGIHRLLDRRSRLLAARVIIVIAGMDGVLPSVVGGLVSCPVVAVPSSRGYGASFGGVAALLTMLNSCAAGVGVMNIDNGFGAGCLAHRINVLGTDGDDPGRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I415</accession>
    <name>A0A1W1I415_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="7">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 15" type="primary">gpsA</name>
        <name evidence="15" type="ORF">NSJP_1574</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 11">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1574"/>
    <dbReference type="EnsemblBacteria" id="SLM47746">
        <property type="protein sequence ID" value="SLM47746"/>
        <property type="gene ID" value="NSJP_1574"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1574"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="13">
        <location>
            <begin position="6"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="14">
        <location>
            <begin position="183"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SLM47746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="338" mass="35562" checksum="66F67FA2729C5D4B" modified="2017-06-07" version="1">MPITRIGVIGAGAWGTALAKHLAEKGLLVRLWAYEREVVESIRASRENRLFLPGVMLPRSLAVTNILGEAVQDCDGLLFAVPSHVARPVLREMAPLLSSGIPVISATKGVEEDSLQLISQIMDDVLPRHMRDRILVLSGPSFAAEVSQGQPTALCLAGRDGELAAAFQAACMTSALRIYADSDLIGVQLGGALKNVMALAAGVVDGLGLGHNTRAALITRGLAEMVRLGTAMGADPRTFYGLSGVGDLVLTCTGTLSRNHTVGVRLGRGEKLETVLSGMQAVAEGVRTARAALGLARRSGVEMPIVQEINAVLFDGKSCRRAVTDLMERGAKPEKGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I474</accession>
    <name>A0A1W1I474_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47775">
        <property type="protein sequence ID" value="SLM47775"/>
        <property type="gene ID" value="NSJP_1603"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1603"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="2">
        <location>
            <begin position="49"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="478" mass="52672" checksum="60CB54221033562B" modified="2017-06-07" version="1">MKSILATMLVSAGLVLTGCFAKIQHLPAQPQGAEALFAPLPDQDFMVGLAVSGGGSRAATFAAGALEALAETPVQFKGSARSVLETVSYMSSVSGGSLATAYYVAKKPPKSEAVLGEQGLSPRYREFFSDYKKAMQTNFQERGLIRQLTYFRALNPTKLAYSLSEVWDAQFLDEITFAQLYERELRGDIPRVILNGTVYNSGQRFAFTTLPAADFDYDFISLLTKELKNPNRPVPLTPEGMAIIQKGLDEASRQFLPLTFERIGADYRNLRLSLAVATSASFPPVVGPVTYQIEGTPRYLHIGDGGLFDNLGTESLTTLFLKKIPQGSPKRGLIIVIDTSFPFDAGAAALDHNDKGFQVFREDPSRVVGIMEERANTYQTLLWHSLRTQGVILPDFAHLRIVVLKHVDAEWTGYQDLPESCRDDFAADVTPLQIKQAVALIPTLFKIKTPCHGALLVKAARKVVEQYKHRIVNFIEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4E1</accession>
    <name>A0A1W1I4E1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative FMN reductase</fullName>
            <ecNumber evidence="2">1.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1700"/>
    <dbReference type="EnsemblBacteria" id="SLM47872">
        <property type="protein sequence ID" value="SLM47872"/>
        <property type="gene ID" value="NSJP_1700"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1700"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="235" mass="26469" checksum="45CB48C99D21067F" modified="2017-06-07" version="1">MTLTYQAEVCRIRDLTHDVRELELALHEPSRLSFKAGQFISFEVPKAGLPQPVVRPYSIASPPSIGDRVTLVFNLVQGGPGSQYLYGLRTGDAVRFKGPAGSFYLREDSNRRMLCVATGTGIAPLWSMIVSELERQSSQPVTLFWGLRYERDLYYREELDGLASRFPRFSFVTCLSQPGPDWTGVRGRVTELVRDRVTSVRDLSVYLCGNGAMIKDVTALIQAKGLCPIYREKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4F3</accession>
    <name>A0A1W1I4F3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47855">
        <property type="protein sequence ID" value="SLM47855"/>
        <property type="gene ID" value="NSJP_1683"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1683"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="71" mass="7800" checksum="B06CECF5F75172E5" modified="2017-06-07" version="1">MDFGVSNRDVEDECSRSRSCAIGLRSATFAEAWALLAAVSLVDAWRRNWIHSKRRLNGSADSDATCPEQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4K7</accession>
    <name>A0A1W1I4K7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fabF</name>
        <name evidence="14" type="ORF">NSJP_1772</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1772"/>
    <dbReference type="EnsemblBacteria" id="SLM47944">
        <property type="protein sequence ID" value="SLM47944"/>
        <property type="gene ID" value="NSJP_1772"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1772"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="9"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM47944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="416" mass="43605" checksum="09FBEEEF39B85D0E" modified="2017-06-07" version="1">MVERSIRRIVVTGLGLVTPLGTGVEKVWKALCAGQSGIGRITKFDPTGYDAQIAGEVKDFDPAQFIEKKEIKKMDAFIHYAVGAAQLAVDDAGLKVAPEEATKVGVYIGSGIGGLGSIEHYHTVLKDKGPGRVSPFFIPMTIINLASGQVAIRLGAKGPNSCAVTACATGNHCIGDAFRLIQRGDADVMIAGGAEAAITTLGVAGFAASKALSFRNAEPTKASRPFDKDRDGFVLGEGAGVLVLEELEHARRRGARIYAELIGYGMNSDAYHITAPSEGGEGAVRCMELALKDAGIRKDQVGYINAHGTSTMADAIETKAIKQVFGDRAFQIPVSSTKSMTGHLLGAAGGIEAVFTVLALHHGMLPPTINLDNPDPECDLDYIPHKARPASVSVALSNSFGFGGVNACLLFKNPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4R5</accession>
    <name>A0A1W1I4R5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Cytochrome c biogenesis protein, ResB-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_1820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1820"/>
    <dbReference type="EnsemblBacteria" id="SLM47992">
        <property type="protein sequence ID" value="SLM47992"/>
        <property type="gene ID" value="NSJP_1820"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1820"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023494">
        <property type="entry name" value="Cyt_c_bgen_Ccs1/CcsB/ResB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007816">
        <property type="entry name" value="ResB-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31566">
        <property type="entry name" value="PTHR31566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05140">
        <property type="entry name" value="ResB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="8">
        <location>
            <begin position="38"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="8">
        <location>
            <begin position="370"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="475" mass="54167" checksum="3B36A20C076AFD8F" modified="2017-06-07" version="1">MNGQPDATAERETPRNPAPGLGWEEFSRELVEFFASIKLAMFLFLFIAVTATIGTVIQQGERPETYIQEYGENAYRWFLRLGITDVYHTWWFTSLLGLLCVNSLTCFYKRFPSVWRSMKQDKVSVSMAFVKGMKQQAEIPVRGDKEAVAQSLAQHFIERGYRVLAKNEAGEVTVYATKGVLGRVGAHMAHLSATVIVVGGLLGSYYGFQEFGVCLEGQTYHIPRGDFDLKVDKFWIDYHENGAVKSYNSTLTVIEGGRPQLTKTITVNDPLVYKGIWFYQSSYGDAWDQIEIARLNIKDKESDKIIKTVDLEWQKEQAIDELKLKLALTDFVADFAFNSTEKKVYSKTVEHANPAIKLTVNERSTVDATPWIFYQFPDLFDIKDSKYQFELIGYKPKKYTGLQIAKNPGINIVWLGSTMIVVGITLSSFIYHRRLWTKIVSSEQGSTVHLGGTTHKSQIDFQKEFRKLTEKIRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4R8</accession>
    <name>A0A1W1I4R8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">ahcY</name>
        <name evidence="9" type="ORF">NSJP_1818</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4 6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1818"/>
    <dbReference type="EnsemblBacteria" id="SLM47990">
        <property type="protein sequence ID" value="SLM47990"/>
        <property type="gene ID" value="NSJP_1818"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1818"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="8">
        <location>
            <begin position="185"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="214"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="293"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="419" mass="46108" checksum="6D9CE3396839B925" modified="2017-06-07" version="1">MDYDVRDIKLADQGRLKIEWAEVTMPVLRLIRKRFKRQQPLKGVRVTACLHVTTETANLAITLKAGGADVRLCASNPLSTQDDVAAALVQHEGIPTFAIKGEDNATYYRHIESAIAHRPHVTMDDGADVVSHLHSKRKDLLRNVIGGTEETTTGVIRLRSMAEKKVLKFPVISVNDADTKHMFDNRYGTGQSTMDGIVRATNRLICGSVVVVVGYGWCGRGIAMRAKGMGADVIVTEIDPLKGLEAVMDGFRVMPMEQAAPIGDFFVTVTGNLHVIRGEHFAVMKDGAIVCNSGHFNVELDIPALEKLAKKRRIVRTGVEEFTFKKNGNRVSLLGEGRLVNLATAEGHPSSVMDMSFANQALGAEYLVKHYKMLEKKVYPVPPAIDKEIARLKLAGMGVEIDTLTTEQKKYLASWEMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I528</accession>
    <name>A0A1W1I528_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Yip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_1761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47933">
        <property type="protein sequence ID" value="SLM47933"/>
        <property type="gene ID" value="NSJP_1761"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1761"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="6">
        <location>
            <begin position="36"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="227" mass="23700" checksum="27F2C6D33B623270" modified="2017-06-07" version="1">MIGSVPCSHFCYMCGCMVASARTMNLVERAKNIVCQPEAEWPVIEPEQISAQVLYTGYIMPLAAIGPVAMLIGMSLIGLEIPSIGTVRIPLPTLVPQVMVGYGLGLAAVYVLALIIDALAPTFGGKRDRMQALKVAAYGATASWVGGIFHLVPALGILGLLAGCYTLYLFSLGLPVLMKSPPERSLGYAMAIMVAAIVLTAVVGILSAVFVEFPAPGGSMSSDPVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I554</accession>
    <name>A0A1W1I554_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48115">
        <property type="protein sequence ID" value="SLM48115"/>
        <property type="gene ID" value="NSJP_1943"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1943"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="105"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="343" mass="37978" checksum="EDA900C48B19CC07" modified="2017-06-07" version="1">MPGVVTAPSATQVKKLPPLFFLGSLLIVFGLAVYFFGIAFSMFRLIFQLGEPFHTWNMTILWYSGLPTTLGLCLAGLDLALLLPAKRRESRRKVLAPVLDRHVVVALTAYNDETSIGLAVADFVSHPLVTRVIVVDNNSRDRTSEAAAEAGARIVVEKEPGYGRCVYRCLKEALSEDGELIVLCEGDMTFRAADIDKLLAYVDHADVVNGTRIVEQLRDYSTQLSTFMYYGNFFVGKLLELKHLGRGTFTDIGTTYKLLRRDSLVRLMPQLNPAVNMEFNAHFLDTALGSGERLVECPITFHPRVGVSKGGNVNNARALKVGLRMILGLCFGWPTSHDPRNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I569</accession>
    <name>A0A1W1I569_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aconitate hydratase A</fullName>
            <ecNumber evidence="4">4.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Iron-responsive protein-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">RNA-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">acnA</name>
        <name evidence="16" type="ORF">NSJP_1801</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1801"/>
    <dbReference type="EnsemblBacteria" id="SLM47973">
        <property type="protein sequence ID" value="SLM47973"/>
        <property type="gene ID" value="NSJP_1801"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1801"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase" evidence="14">
        <location>
            <begin position="32"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="15">
        <location>
            <begin position="555"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SLM47973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="748" mass="80722" checksum="3FAC2E09AB4FA5B6" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5C9</accession>
    <name>A0A1W1I5C9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_1861</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48033">
        <property type="protein sequence ID" value="SLM48033"/>
        <property type="gene ID" value="NSJP_1861"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1861"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="56"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="166"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="429" mass="47934" checksum="5385CB4131CEF60D" modified="2017-06-07" version="1">MACVRKRRGKYVVDWRDGAGVRHWKTFDRKVDAEAHRDKVGPEARQRVTPAVPATITLSEYATHWKRLIGQAVKARTLARYSEILTLHLLPRFEKVRVRDLDRGRIKILLAEKLESGLERRTVRNIHATLRTLLNAAIEDGVIVANPAARLGRTLKLTVAKSTIQEEIKAMTKAQRLQFLATAQKVAPRYYPLFFILAGTGMRLGEALALQWSDLDRGAKTIRIARAFAEDGTLDTPKSGHGRTVDLSQALTDALVTHEEQHRRDHLRYEWTECPPWLVVTKAGTPVDPANVRRTMARVLTSAMLPTHFTPHCLRHTYASILLADGVSPAYVQEQLGHATIELTVSTYGRWLKKKAPGVLDQLDAVVKEQTHAVAVSEPGSKVVAETQSAVTVASTPMDQRAYIEGFMLEPATRIERATCGLRNRCSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5I9</accession>
    <name>A0A1W1I5I9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Efflux transporter, RND family, MFP subunit, Macrolide-specific efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">macA</name>
        <name evidence="4" type="ORF">NSJP_2088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48260">
        <property type="protein sequence ID" value="SLM48260"/>
        <property type="gene ID" value="NSJP_2088"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2088"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="59"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="417" mass="44431" checksum="D2F2A0CE6FD9451C" modified="2017-06-07" version="1">MRRLVLIVAVLAVGLVIGGYVFFNGERKTPIRYRSASVERGTVVSLVTATGTIAPVVSVQVGTQVSGMIKSLHADFNSVVKAGDIVAVIDPEPFRARRDQAASNLEMARATLARARTEQAQRHRELERTKSLLSQQFVSQNDVDVALTNAQGAEAQVSVAIAQGKQAEAALNAAELDLKYTVIRSPVNGIVVARNVEVGQTVAASFATPNLFLIALDLTKMEVDTNVSESDIGGITEGKDAMFTVDAYPGVPFSGTIRQVRIAPINVQNVVTYNVVVGVDNKDLRLKPGMTANVSIVVAQRENVLKIPNAALRFMPPKSELVNGSPSGAGVRAVATGDVGGLPSRFVWKERENGELVSVPVQGGISDGLWTELVSGDVAEGEAVIVGIEQFRGERRSSDLPPGFGAPPRRQSRERGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5J4</accession>
    <name>A0A1W1I5J4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Cell shape-determining protein MreD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48201">
        <property type="protein sequence ID" value="SLM48201"/>
        <property type="gene ID" value="NSJP_2029"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2029"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="166" mass="17471" checksum="3BBB0CFAEA91EEE5" modified="2017-06-07" version="1">MKILIYSMVIVLLVPLQTTLLPHVSIWGLTPDVGLAVAALIGLFAGELEGFVVGLAIGWILNMYSAGDLWISLITKGGVGLLAGLFGQHVAHVTPTVVSVGLLIVSVLSGTMVVLTMKNAAGIDTWWMVQSMVLPQACLDAVAGAGLFYLASQRLAADRVLMSDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5K5</accession>
    <name>A0A1W1I5K5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">coaE</name>
        <name evidence="2" type="ORF">NSJP_2125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2125"/>
    <dbReference type="EnsemblBacteria" id="SLM48297">
        <property type="protein sequence ID" value="SLM48297"/>
        <property type="gene ID" value="NSJP_2125"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2125"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="200" mass="22300" checksum="5D59C993FC1E49A5" modified="2017-06-07" version="1">MILVGLTGGVATGKSTVARMFEQCGAVVISADVLAREVVRPRASAWREIVAEFGRSILKSDHTIDRKGLGDIVFRNPRKRRKLERIVHPRVARLQASMTRQAAKHNRHAVVVYEVPLLFEAGVDRRVDRIVVVTAPRSTQIARLKTRDGLPRSESLRRIDSQFSMDRKVARADAVLNGAAPLPALRAQVRKLYRQLLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5P7</accession>
    <name>A0A1W1I5P7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DctA-YdbH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2133"/>
    <dbReference type="EnsemblBacteria" id="SLM48305">
        <property type="protein sequence ID" value="SLM48305"/>
        <property type="gene ID" value="NSJP_2133"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2133"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021730">
        <property type="entry name" value="DctA-YdbH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11739">
        <property type="entry name" value="DctA-YdbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DctA-YdbH" evidence="1">
        <location>
            <begin position="714"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="928" mass="99952" checksum="93F7096140123E21" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5V2</accession>
    <name>A0A1W1I5V2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2198"/>
    <dbReference type="EnsemblBacteria" id="SLM48370">
        <property type="protein sequence ID" value="SLM48370"/>
        <property type="gene ID" value="NSJP_2198"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2198"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014995">
        <property type="entry name" value="DUF1844"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08899">
        <property type="entry name" value="DUF1844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="130" mass="13956" checksum="13295992A8E8F0CF" modified="2017-06-07" version="1">MATDKEEGFVVRDRRGGGSTEQPAATPPPLWAESAGKVSPDDPGQAHDIPVTFASFVISLGSSSLMLMGEKLDPQQPAMPVNLPQAKEIIDLLSILEEKTVGNLTTEEQAVLRDMLYALRMKYVSLSAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5W7</accession>
    <name>A0A1W1I5W7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48223">
        <property type="protein sequence ID" value="SLM48223"/>
        <property type="gene ID" value="NSJP_2051"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2051"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="186" mass="21029" checksum="80080BDEC359D549" modified="2017-06-07" version="1">MRQPHQITVDRALLLLVLQCAEPHGLLSDVKLQQLCFLCELQMFGKGFKGFHFEFFRFAYGAFSKDLDNDLTSLRRRERVENFTLTEQAQEVLSLLEKSVAGVETNEKIVEILKAVVATYGGHDSGAITNSVESVELSTPQDPEFKIPIRDIVFHTTLLVPSRIEVKNEFQLPPALLPKINHAMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I651</accession>
    <name>A0A1W1I651_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48487">
        <property type="protein sequence ID" value="SLM48487"/>
        <property type="gene ID" value="NSJP_2315"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2315"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="71" mass="7712" checksum="2916E44CAD8BD0FB" modified="2017-06-07" version="1">MAKKGTESDESRLKKKVATKLSGHENPEGDAALRALRKRLKREQRKRRALALRKKHAGANKPAAEGAPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6B8</accession>
    <name>A0A1W1I6B8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease subunit gamma</fullName>
            <ecNumber evidence="4">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Urea amidohydrolase subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">ureA</name>
        <name evidence="5" type="ORF">NSJP_2396</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the urease gamma subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2396"/>
    <dbReference type="EnsemblBacteria" id="SLM48568">
        <property type="protein sequence ID" value="SLM48568"/>
        <property type="gene ID" value="NSJP_2396"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2396"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00739">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012010">
        <property type="entry name" value="Urease_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001223">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="SSF54111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="100" mass="10998" checksum="79A590E2B4867492" modified="2017-06-07" version="1">MHLTPREMDKLLIYMMAEVALKRKAKGLKLNHPEAVAVITASALDGAREGKSLEQVMKEARSTLTRDDVMEGVAEMIPLVQLEAVFTDGSRLVTVHGPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6G1</accession>
    <name>A0A1W1I6G1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative RNA polymerase sigma factor FecI (Sigma-19)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2424"/>
    <dbReference type="EnsemblBacteria" id="SLM48596">
        <property type="protein sequence ID" value="SLM48596"/>
        <property type="gene ID" value="NSJP_2424"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2424"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM48596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="174" mass="19471" checksum="34090823C0F0357D" modified="2017-06-07" version="1">MILTVGEIERLFDEQRHLLTRHLTRLVSSRELATDLVQEAFARLLGMVGKQQVAYPRSLLYRTAINLAIDHLRTRKTETHSLADASMLEAALEVASPTPAADRALSAKQQLQIVASAIDQLPPRTRQAFLLHRVHGYSYAQIATQLGISESAVEKLITRALKQCWHAVNLLDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6I1</accession>
    <name>A0A1W1I6I1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">purC</name>
        <name evidence="10" type="ORF">NSJP_2445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2445"/>
    <dbReference type="EnsemblBacteria" id="SLM48617">
        <property type="protein sequence ID" value="SLM48617"/>
        <property type="gene ID" value="NSJP_2445"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2445"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01415">
        <property type="entry name" value="SAICAR_synt_PurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033934">
        <property type="entry name" value="SAICAR_synt_PurC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="9">
        <location>
            <begin position="7"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM48617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="234" mass="26599" checksum="E2B4680F53DA0FCC" modified="2017-06-07" version="1">MTSGTMIYEGKAKKIFTTSDPDQVVQYFKDDATAFNAQKRGTILEKGVVNNKVSERLFRLLEQNGVPTHFVARTSDREMLTKKVAIVPVEVVVRNVVAGSLAKRLGLKEGEPIEPAIVEWYYKNDALGDPLIADDHVRLLKLATPEQMAEIRKLALKVNGVLQPFFGERRMILVDFKLEFGLYNATLILADEISPDTCRFWDQTTKESMDKDRFRKDLGRIEEAYQEVLKRVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6K0</accession>
    <name>A0A1W1I6K0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative Histidine kinase</fullName>
            <ecNumber evidence="13">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NSJP_2433</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="13"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2433"/>
    <dbReference type="EnsemblBacteria" id="SLM48605">
        <property type="protein sequence ID" value="SLM48605"/>
        <property type="gene ID" value="NSJP_2433"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2433"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="131"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="209"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="260"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="334"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="405"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="659"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="12">
        <location>
            <begin position="798"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="708"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="5">
        <location>
            <position position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM48605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="902" mass="99809" checksum="F631FC05602714FB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6W5</accession>
    <name>A0A1W1I6W5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-C factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sigC</name>
        <name evidence="7" type="ORF">NSJP_2437</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2437"/>
    <dbReference type="EnsemblBacteria" id="SLM48609">
        <property type="protein sequence ID" value="SLM48609"/>
        <property type="gene ID" value="NSJP_2437"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2437"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="332" mass="38326" checksum="85124B6655B12694" modified="2017-06-07" version="1">MKRKNKPAAEAPLEPEILGPSEEDPVEEQTKTDTGSDDAPATRAAVDTTAVVPVTALQQYLAEVRRHPYLTKEEEQRLFEEYRTHGSREAAVKLIMANLRVSVAIASEYLHTGADHMDLIQEGNVGLMQAIKKFDPSKNVRFYAYAAWWSRAYILRYLLNTYRLVKIGTTQDQRKLFYNLKKEKAKLERQGFAPDTKLLADRLNVRERDVVEMDQRLGNWELSLDQPIGEEQDGTLLDVLPSQQVGADEQLAQHQLQTLFRAKLAEFVKTLDERDEDILRNRLLSETPLTLDDLGEKYGITKERTRQLEARIIKRIRDYIKKDVKDFDRLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I704</accession>
    <name>A0A1W1I704_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">udgA</name>
        <name evidence="11" type="ORF">NSJP_2629</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2629"/>
    <dbReference type="EnsemblBacteria" id="SLM48796">
        <property type="protein sequence ID" value="SLM48796"/>
        <property type="gene ID" value="NSJP_2629"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2629"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="10">
        <location>
            <begin position="28"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM48796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="214" mass="23728" checksum="6FA80E09153C8FAE" modified="2017-06-07" version="1">MTLPELAKSLHNCQLCKLAKLGRSQVVFGVGNPHASIMFVGEAPGFNEDQKGEPFVGAAGKLLNDLLQSANLSRDQIYIANVIKCRPPNNRDPEPDEVETCKPFLMQQIQMIRPKLVCTLGNWATQTLLERKVGITKVKAQPFYMKDFVLFPLLHPAAALHQGNLLETLRDDFKKLKEFLDRHTQPVASESAEPTAPALTIEPPNPAQMDLFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7A1</accession>
    <name>A0A1W1I7A1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphate-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sphX</name>
        <name evidence="6" type="ORF">NSJP_2720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the system for phosphate transport across the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2720"/>
    <dbReference type="EnsemblBacteria" id="SLM48887">
        <property type="protein sequence ID" value="SLM48887"/>
        <property type="gene ID" value="NSJP_2720"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2720"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011862">
        <property type="entry name" value="Phos-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12727">
        <property type="entry name" value="PBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02136">
        <property type="entry name" value="ptsS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027152171" description="Phosphate-binding protein" evidence="4">
        <location>
            <begin position="25"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="5">
        <location>
            <begin position="51"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="337" mass="36767" checksum="F975EB79656E14B4" modified="2017-06-07" version="1">MRRMQRPGSVVASLGLAGLLVWCAAPTWPQTTALVKVDGSSTVFPITEAVAEEFQKTARGAVRVTVGISGTGGGFKKFCRGETDIQDASRPIQSGEMEVCRTNGVSYIELPIAFDALTIAVSPQATWVDHFTLDELKRIWEPSAQGRVMKWSQVRPTWPDLPLKLFGAGADSGTFDYFTEAVVGKAKASRGDYTASEDDNTLVQGISHDKQALGYVPYAYFEPNQQRLKAIAIDGGKGPVLPSRVTVENGTYQPLSRPLFIYVNAKAAERSEVKRFVEFYLAQTATLAPQVKYVPLPAQAYELALAHFRNGKVGTAFQGTSTIGIKIEELLRREATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7F7</accession>
    <name>A0A1W1I7F7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48946">
        <property type="protein sequence ID" value="SLM48946"/>
        <property type="gene ID" value="NSJP_2779"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2779"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="110" mass="11811" checksum="495E4F8C29282185" modified="2017-06-07" version="1">MSGRRLFPQHRMLTWLSSGVLALGLLSFVLGLTFSSESASISWAQPVVVDGEEADPLEDAIGSTVSDHQAASRIVLAGSRIGHHAPPWVTRGLVHDIVFFDLASRPPPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7J3</accession>
    <name>A0A1W1I7J3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tetracenomycin polyketide synthesis 8-O-methyl transferase TcmO</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tcmO</name>
        <name evidence="6" type="ORF">NSJP_2788</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2788"/>
    <dbReference type="EnsemblBacteria" id="SLM48955">
        <property type="protein sequence ID" value="SLM48955"/>
        <property type="gene ID" value="NSJP_2788"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2788"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031725">
        <property type="entry name" value="ASMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="PTHR11746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16864">
        <property type="entry name" value="Dimerisation2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dimerisation2" evidence="5">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_2" evidence="4">
        <location>
            <begin position="110"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="226"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="337" mass="37220" checksum="EE3753349E990FBF" modified="2017-06-07" version="1">MATQRVSPVRIMEIGMGFLPSKALLSAVELGLFTELRKGPLEGEALRKKLGLHQRSARDFFDALVALGLLKRSGTRYANTAETAMFLDRTKASYVGGILEMANERLYRFWGSLTEGLRSGQPQNEARTGEDFFGTLYADPHRLENFLKAMTGLSLGTAKVIAGKFPWKRYRTFVDVGCAQGGVAGEIALAHKHLTGAGMDLPVVQPVFDAYVKGKGLDRRLRFHAGDFFKDPLPRTDVLIMGHILHDWNLDEKMMLLRKAYEALPQGGALIVHEALIDDARKTNAFGLLMSLNMLIETPGGFDFTGADCRAWMKEVGFKRTKVERLAGPDGMVVGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7L2</accession>
    <name>A0A1W1I7L2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulfate transporter subunit periplasmic-binding component of ABC superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sbp</name>
        <name evidence="6" type="ORF">NSJP_2823</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic sulfate-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2823"/>
    <dbReference type="EnsemblBacteria" id="SLM48990">
        <property type="protein sequence ID" value="SLM48990"/>
        <property type="gene ID" value="NSJP_2823"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2823"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902358">
        <property type="term" value="P:sulfate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01005">
        <property type="entry name" value="PBP2_CysP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005669">
        <property type="entry name" value="Thiosulph/SO4-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30368">
        <property type="entry name" value="PTHR30368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00971">
        <property type="entry name" value="3a0106s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="356" mass="39199" checksum="628B3E7EED406EFF" modified="2017-06-07" version="1">MNECFRHSWSAGVLVIWTILAVCSIGHSTNAMADSQELLNVSYDVSREFYKAYNAAFARHWLEKTGRSAVLRQSHGGSTAQARAVLAGLEADVVTMNQESDIAILAEQGGPIAKNWRERLPNHSVPFTSTIVFLVRSGNPKRLHDWPDLIRPGVAVIMPNPKTSGNGRYSYLAAWGQLVKQTGSHDKARQFVHDLLQHVPVFASGGRGATTTFLQRDIGDVLLTFEHEVSLIQKEAGTGRFEIVYPTVSILAESPVAVVDRVADKHGTRVLAEAYLDYLYSEEGQELAARHHYRPSSAAVMRKHASQFPALNVFSADDVFGGWQNAIATHFSSGGVFDQMYQPTAAPSDGHREQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7P4</accession>
    <name>A0A1W1I7P4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2875"/>
    <dbReference type="EnsemblBacteria" id="SLM49042">
        <property type="protein sequence ID" value="SLM49042"/>
        <property type="gene ID" value="NSJP_2875"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2875"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025333">
        <property type="entry name" value="DUF4239"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14023">
        <property type="entry name" value="DUF4239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="257" mass="28357" checksum="0C703785CB43F46F" modified="2017-06-07" version="1">MSYNASTELLLVGLFAGMMIALVIGQRLGRRDRSEDTDSTLLRLTAVEAAIFGLMGLMIAFTFSGAADRYEMRRQLVVDEANNIGTAYLRLDLLPASKQPALREQYRQYVKARLGAYRGSDLDMSNAEMAKVAALQQDMWSGTVAALEAVDPEFVDFVLSPLNDLIEITTSRTIAALSHTPKLIMAMLLLLSLVCSLLAGYVIAGIQTRQVGLHLLAFAFVMTATIFLIIDLDYPRDGIIRLDFADKALEDLLVRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7X8</accession>
    <name>A0A1W1I7X8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2965"/>
    <dbReference type="EnsemblBacteria" id="SLM49132">
        <property type="protein sequence ID" value="SLM49132"/>
        <property type="gene ID" value="NSJP_2965"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2965"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028203">
        <property type="entry name" value="PSII_CF48-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14870">
        <property type="entry name" value="PSII_BNR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013320486" evidence="1">
        <location>
            <begin position="25"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="PSII_BNR" evidence="2">
        <location>
            <begin position="71"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="PSII_BNR" evidence="2">
        <location>
            <begin position="205"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="322" mass="34349" checksum="7C2C240D97D56753" modified="2017-06-07" version="1">MSALTSFVSFLLCSFLLAANPSIAGDATVSVSKQTSHTEATLLGLTFRNPQLGWAVGSGGTILKTIDGGKKWRRISSGTTALLTNVYFRDQKVGWIIGANATVRRTGDGGETWTAQPVDTQAPLYGISFPSDSHGWIVGGNGTILHTQDGGSHWTEQASKTNAALYSVQFVSEQHGVAVGAVGTVVVTDDGGVTWVVQEPQGSVTFFDVFFPDPSTGWAVGNAGALFHTTDGGRQWIDRTLPCTTQSCTKLTDLLRVRFTDPQSGWIVGERGMLYRTIDGGFTWREQGSIAAVSLFGLAFPDPKQAWATGEKGTIVQLKIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7Z0</accession>
    <name>A0A1W1I7Z0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49114">
        <property type="protein sequence ID" value="SLM49114"/>
        <property type="gene ID" value="NSJP_2947"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2947"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="70" mass="7865" checksum="994A6D27C88BF0B5" modified="2017-06-07" version="1">MADNNAIYAIRHNDGSISLYIDEDYARDRGIDPATLTRVEIPRELYVSGSIQQVREYVATYLEAQITGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I853</accession>
    <name>A0A1W1I853_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4384 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49180">
        <property type="protein sequence ID" value="SLM49180"/>
        <property type="gene ID" value="NSJP_3013"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3013"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025493">
        <property type="entry name" value="DUF4384"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14326">
        <property type="entry name" value="DUF4384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4384" evidence="2">
        <location>
            <begin position="411"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="566" mass="61453" checksum="C8474B69FD413CB5" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I882</accession>
    <name>A0A1W1I882_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49210">
        <property type="protein sequence ID" value="SLM49210"/>
        <property type="gene ID" value="NSJP_3043"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3043"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013003673" evidence="2">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="193" mass="19669" checksum="C9263A5F08849CF8" modified="2017-06-07" version="1">MRVRTQWLLMVALLLVIPAHAADDIQERAVPNTGVRQGLQAEGSMSATDMRLAKLQQQVELLTAQLAALQSVIKLTPGGVTLQAPTLTIVTSEALTLQSTKSVTIAAGTSLDARASMTTTIRSGSSAALEAGGSLDLKGGVVKFNGGGMPLATVGNRVQIRPGQVIGTVQGGVVVGTSVIGDIVTGSTTLLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I899</accession>
    <name>A0A1W1I899_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49215">
        <property type="protein sequence ID" value="SLM49215"/>
        <property type="gene ID" value="NSJP_3048"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3048"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="87" mass="10048" checksum="EABF4BEC10B619DD" modified="2017-06-07" version="1">MSVNLATMTHHTQQEQTESRTRGKSLLPVCCMCGLIRIESQSPAAPERWVTSRLYEKTHQIDPRECLFTHTYCPGCYTKFMRKVRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8J7</accession>
    <name>A0A1W1I8J7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3148"/>
    <dbReference type="EnsemblBacteria" id="SLM49315">
        <property type="protein sequence ID" value="SLM49315"/>
        <property type="gene ID" value="NSJP_3148"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3148"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="59"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="231"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="687" mass="75802" checksum="CCA36745B2FFC7C4" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8L3</accession>
    <name>A0A1W1I8L3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49346">
        <property type="protein sequence ID" value="SLM49346"/>
        <property type="gene ID" value="NSJP_3179"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3179"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="108" mass="12031" checksum="170E78F70B2CDE5D" modified="2017-06-07" version="1">MVTRKFKRYPVSLNSTLVHKDQFRHKGAIRDLSAKGCRVDSLLTPFTGMQVTLLLHVPGEAAPITIENAAIRWCGSQGIGMEFLILTKPDETRLSRMIQQLEAGAVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8M3</accession>
    <name>A0A1W1I8M3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent protein deacylase</fullName>
            <ecNumber evidence="3">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">cobB</name>
        <name evidence="5" type="ORF">NSJP_2976</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:47668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11877"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87830"/>
            <dbReference type="ChEBI" id="CHEBI:87832"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">2 residues (Tyr-67 and Arg-70) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2976"/>
    <dbReference type="EnsemblBacteria" id="SLM49143">
        <property type="protein sequence ID" value="SLM49143"/>
        <property type="gene ID" value="NSJP_2976"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2976"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034979">
        <property type="term" value="F:NAD-dependent protein deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006476">
        <property type="term" value="P:protein deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01412">
        <property type="entry name" value="SIRT5_Af1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01121">
        <property type="entry name" value="Sirtuin_ClassIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="101"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="187"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="213"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="239" mass="26222" checksum="0D91B047A8356ACE" modified="2017-06-07" version="1">MKSDLATLKSALASAHAITVLTGAGISSDSGVPTFRGTDGLWRNFRVEDLATPEAFARDPRLVWEWYNWRRELIASKQPNPAHHAVVEIERRAGRFWLITQNVDGLHRSAGSEKLSEIHGNIWMVRCTLCGRIEDNRDVPITLLPSCRHCGGLLRPHIVWFGEPLRHEDLAQSTLALKQCDVLLVIGTSGVVYPAAGFAAVAKEAGAFVAEINPEPTPQSAAVDLVLRGRAKEILPLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8P7</accession>
    <name>A0A1W1I8P7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49392">
        <property type="protein sequence ID" value="SLM49392"/>
        <property type="gene ID" value="NSJP_3225"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3225"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="202" mass="23287" checksum="B146D0890FE37E9E" modified="2017-06-07" version="1">MRSSAGYQSTWLGPATGSMCRTVVALACLAGLSGCNTYELRQENQSNARNQVWLSETSQLKIRAAQTRVFDTTDRLKLLQAVVSTMQDLDFKVEVLDQDLGIVSGKKFVEVETGYMADPVYYYLYRPDTMMFLARNYRSWGPFYYRSNLVRFTATIRPRGETQSLIRVSVQYYMHALEDPKAYQEFFRTLEQSLFLQGHEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8X9</accession>
    <name>A0A1W1I8X9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">oliA</name>
        <name evidence="7" type="ORF">NSJP_3310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3310"/>
    <dbReference type="EnsemblBacteria" id="SLM49477">
        <property type="protein sequence ID" value="SLM49477"/>
        <property type="gene ID" value="NSJP_3310"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3310"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004814">
        <property type="entry name" value="Oligopep_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="PTHR31645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00733">
        <property type="entry name" value="TIGR00733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="592"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="662" mass="68956" checksum="537D1B0023807973" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8Y7</accession>
    <name>A0A1W1I8Y7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Outer membrane protein TolC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3331"/>
    <dbReference type="EnsemblBacteria" id="SLM49498">
        <property type="protein sequence ID" value="SLM49498"/>
        <property type="gene ID" value="NSJP_3331"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3331"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="471" mass="53070" checksum="9C8226A3497AE3DF" modified="2017-06-07" version="1">MDDPHAPELPKMRRCFLHMAAVFVFLVVVASSLLIVETSVRAANITEPTENWIEQILKGLFKQDQYPDPLPKQTPLPLPTKFMQLSLSEAMELFLKQNLDLIIAHYGIDAAKGRHITARLFPNPTLNVNTLSSYTQGCQMSTCGAVGPSVSQLFEVAGKRGYRIRAAELEVLSVEARFEDAVRQLGFTLKDNYFRVQRQRGHLSIDQRALNILIKLLQPDKKKQFTSDLERTRLGLLTVNTEAEVLRDLQRVEDASGDLRVMLRLSPDVELDLETPLIYRSLDLKLDELMEYASQNRPDIRALRLVRDRRKTQLQLAKVIPYPNVTANLGYAVQGPHGPDNQQQWGFGLSVPIPVFDRNQGGIMEAEVASKAAEAEVEKALIQMQNDIGVAYRKVLHSKKLVDVTNGAIDRATTVFQSAQEGYAKNEIGILDLENSRRSYGDTEISHLDALFGYYENLLLLERSTGRNIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I900</accession>
    <name>A0A1W1I900_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49497">
        <property type="protein sequence ID" value="SLM49497"/>
        <property type="gene ID" value="NSJP_3330"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3330"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="306" mass="32648" checksum="585EFFAF14037876" modified="2017-06-07" version="1">MRLRGTLYEITNIGSFVQEYMTNRSQPGTSSVSPVPNARVILDGLNQPGRGSAFLVESNTDGTGRFDLDVSMSSDMPVFLSASGRADVSKGIIESEPQSGRWYRSSPFVPHAVDGKQCDVYVARVAIPREAGFSQPRLTTALAETKKEVANLEWIKGKIKPEGITLSCGGKGATASGRVVLNPDTSADPSKILHHTVEEFRLELPWLVGLVVSKDTVEASLRAGLADLVAEVGKQLRLSAIRLLSAQLPCSDPTAVDKIVSKATLSFSHLEYEAIPADGQSKASCTIVGEACFGFPGTLESADARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I902</accession>
    <name>A0A1W1I902_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49476">
        <property type="protein sequence ID" value="SLM49476"/>
        <property type="gene ID" value="NSJP_3309"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3309"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="163" mass="18678" checksum="BB1E001C5698C7A4" modified="2017-06-07" version="1">MKTVPILFHDIDGVLFGDYAGEFQLRPGVKSWLAWAHEHFELVWLTSWESERIKTLLKVLYCEKFRPDEDPPVFHHANWTKLENKVAWVQQAVQKLNGREWFWIDDDIGKFEPEIEAAGIPLTRCIQANPAGQDELTVIQSVLARRLAGLGTNVDGPEKDRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I990</accession>
    <name>A0A1W1I990_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49501">
        <property type="protein sequence ID" value="SLM49501"/>
        <property type="gene ID" value="NSJP_3334"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3334"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033456">
        <property type="entry name" value="DUF5132"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17195">
        <property type="entry name" value="DUF5132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="68" mass="7176" checksum="E98935B29C171CB7" modified="2017-06-07" version="1">MTDFLSGIGSALRPLAKELIKGGIYLFDSVSEAASEAGEQFKDLVAEAKTDLAKQNSASVAKEPTEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9A6</accession>
    <name>A0A1W1I9A6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3451"/>
    <dbReference type="EnsemblBacteria" id="SLM49618">
        <property type="protein sequence ID" value="SLM49618"/>
        <property type="gene ID" value="NSJP_3451"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3451"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="27"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="218"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="400" mass="44513" checksum="9B6C435390047E60" modified="2017-06-07" version="1">MKVLVAHNHYRSSAPSGEDQVFQNEVTLLRRHGIDVTIFERFNDDIDDSSLAGRLRVAHETAWSDRSYQDLEWVLRKSRPDVVHFHNTFPIISPSAYAACRDNGVPVVQTLHNFRLICPGGLLLRNGTPCEKCIGGGLFSALRHRCYRGSLPATGALVWMLLFNRWRDTYGSLVNRYIALTEFAAGRLIAGGLPRERVAIKPNFVSDIHVPGDGQGGFAVYVGRLSQEKGVHTLLSAWKTVQGVPLRVLGDGPLRKSLEEYVSRENLPIQFLGFCNRRTVIDTVSRAAFQIVPSEWYEGFPMVIADAYALGTPIIASRIGSLEEIVEEGVTGTRFEAGNAADLAAKVQALWHDHSHRATLRQGARHAYESKFSAERNFEMLIAVYEAAMGEHTQLSRKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9C1</accession>
    <name>A0A1W1I9C1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1232 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3312</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49479">
        <property type="protein sequence ID" value="SLM49479"/>
        <property type="gene ID" value="NSJP_3312"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3312"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010652">
        <property type="entry name" value="DUF1232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06803">
        <property type="entry name" value="DUF1232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1232" evidence="6">
        <location>
            <begin position="64"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="128" mass="14145" checksum="7F08DCB2701F924B" modified="2017-06-07" version="1">MFGQYGGRAGRYLRDKERLQRLIGEALSMARARGGAIWTDIQLLTRLLKAWMNGAYHGVSAQTLVAIVAALIYFINPFDAVPDFIPGLGYIDDAALIAWLLKSLAGDLDQFKNWEDRNGSAESPQETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9E2</accession>
    <name>A0A1W1I9E2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3438"/>
    <dbReference type="EnsemblBacteria" id="SLM49605">
        <property type="protein sequence ID" value="SLM49605"/>
        <property type="gene ID" value="NSJP_3438"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3438"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="120"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="195" mass="22180" checksum="F1369BB4B55A570F" modified="2017-06-07" version="1">MQKRISSLRSKTEESMDCAVDTMMQERVDSYFRVEQGLDEIVKSLLQIEEELEGVSDLSGAMRLESRLEFVEDRWDDLDSEIRERPRRRRRKLNLADMLKAAGGGGGDLSQSSSVNNAVDAYAIMGVEFGSSLADVTTAFRHKAKQLHPDANQGDRSSEPELRRMLEAYQFLKEYLSLTNTEPMRPPDRPYSPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9E8</accession>
    <name>A0A1W1I9E8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3 4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">gmd</name>
        <name evidence="6" type="ORF">NSJP_3459</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O</text>
            <dbReference type="Rhea" id="RHEA:23820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="EC" id="4.2.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3 4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3459"/>
    <dbReference type="EnsemblBacteria" id="SLM49626">
        <property type="protein sequence ID" value="SLM49626"/>
        <property type="gene ID" value="NSJP_3459"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3459"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019673">
        <property type="term" value="P:GDP-mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="PTHR43715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="5">
        <location>
            <begin position="5"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="336" mass="38310" checksum="559355DA8DF19790" modified="2017-06-07" version="1">MKKALITGITGQDGSYLSEFLLAKGYEVYGIIRRSSSFNTGRIEGIYEDPHVPHRRLHLVYGDLNDASSLNHILRTVQPDEIYNLGAQSHVRVSFDIPEYTGEVTGLGTIRLLEAIRESGLRPKFYQASSSEMFGKVLEVPQRETTPFYPRSPYGAAKVYSYWITVNYREAYNLFACNGILFNHESPRRGETFVTRKITKAAARIKLGIQHDLFLGNLEAKRDWGFAGDYIQAMWMMLQAKSPDDYVIATGETHTVREMLELAFDRVSVDWKKHVKIDEKYYRPTEVDLLIGDAGKAKRELGWEPKVGFDELVAMMVDADLAAEKERLEGVRPRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9M6</accession>
    <name>A0A1W1I9M6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49685">
        <property type="protein sequence ID" value="SLM49685"/>
        <property type="gene ID" value="NSJP_3518"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3518"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="173" mass="18840" checksum="234E073C8D02DF9D" modified="2017-06-07" version="1">MPKLVTVWRKDDILSQAKHYVRSYILLPSGILGLVCMLGGIGGLGYQFVTGGSYTWNTFVASSGLLILGGLCGAAQTVYHRHLLSTVPEVFAARMRAIVSRPGKKGKADPQHEEVRHTGRALVPFAYVIGAGSLFAGSIWAFQSGWVEAIPAVLMPWAGFYWGKLLLWRGIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Q1</accession>
    <name>A0A1W1I9Q1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49523">
        <property type="protein sequence ID" value="SLM49523"/>
        <property type="gene ID" value="NSJP_3356"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3356"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13192">
        <property type="entry name" value="Thioredoxin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="1">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="101" mass="11040" checksum="E6ACC528493D2EEE" modified="2017-06-07" version="1">MNLVLAGCYNPHAMPNITLLVSPSCGACPSAKSLWKQLRVKYSFSYREVDITTPDGQELAGRHAVRAVPATIIDGRLTFVGVPSRESAEKALQLKMRPREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9Y0</accession>
    <name>A0A1W1I9Y0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Vitamin B12 import system, ATP-binding protein BtuD</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3554"/>
    <dbReference type="EnsemblBacteria" id="SLM49721">
        <property type="protein sequence ID" value="SLM49721"/>
        <property type="gene ID" value="NSJP_3554"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3554"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="25"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="63"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="296" mass="33192" checksum="450F751B5FB6DAFF" modified="2017-06-07" version="1">MTAYPGHDLSSEPSESVDRGPFPVYDARSVRFHYGRMDPDAPQWALRDVSFSVKPGEMLGIVGPNGSGKTSLLKLLARIIPEQQGTIRLFGNRLTELRQEDVARDVGFVPQDTSQTFPFTVTETVLMGRFPHRHRAPWDLGFGWDSPGDRAIAQQAMVTMDVWKLATRRVTELSGGERQRVVIARALTQEPRVLLLDEPTAFLDLQHQVGICVLLHRLKQERGLTIVLVSHDLNLASQYCDRVLLLDRGQVVRLGVPSEVVQRDVLEAVYRCRVLVDCHPVSGLPRVTLPSRDMVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA93</accession>
    <name>A0A1W1IA93_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49967">
        <property type="protein sequence ID" value="SLM49967"/>
        <property type="gene ID" value="NSJP_3800"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3800"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="40"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="378" mass="41846" checksum="8B4EA77CEE936821" modified="2017-06-07" version="1">MPYTNQHVSKNSESTLSLSSVDEGIAVSSQVGWDEQAIPAREIHVLVVSNHWGVKKQCSPAGVFVDRQVNSLENVGVRITTFDVGTSLSLSQCFKKWLKLRRLIDSIKPDVIHGRNGTIVGFMSTLSGRPSVVTFCGGDLLLRPQIPLLRQYLGFLLSNLAAVWASEVICVSEELHQTLWWRRRAFVIPDGVDLELFKPGPQHLARKELGWDLDRPIALFSIGGDREKLKGLELVEAAMANVRRQVPTAELKIISNVEPSRMPLYYRASDVLLFASLVEGSPNMVKEALACNLPIVSTPVGDVAERLADVRPSRVVPREPRVFGDAVVEILQTRERSNGRELVASLGLSHIAEQVRNVYLSLLGGESIPELSRLHSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAC4</accession>
    <name>A0A1W1IAC4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49829">
        <property type="protein sequence ID" value="SLM49829"/>
        <property type="gene ID" value="NSJP_3662"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3662"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="125" mass="13998" checksum="4B3EDD1F7D0F5D58" modified="2017-06-07" version="1">MRSLCVTVMNVDQTRDEREGYALVRENVPRGRFLAAMATKHLRGGRHRACICRISEVMSTRHELHGAASSFDVISAKAGIEPHQDSMLRRRPRSYSYHAGEGLKPASLIVVFDVFFRDTVTIPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAD8</accession>
    <name>A0A1W1IAD8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50018">
        <property type="protein sequence ID" value="SLM50018"/>
        <property type="gene ID" value="NSJP_3851"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3851"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014094">
        <property type="entry name" value="LpoB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13036">
        <property type="entry name" value="LpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="209" mass="23178" checksum="7C2C7FE2E0D22B8A" modified="2017-06-07" version="1">MGSIGQRGFAGAVGSVVLCFGFLTLAGCGSETKVTRVDTGVVTDLSGRWNDTDSRMVAEAMVKEALDYPWLGNFSAAKNRQPVVVVGTVLNNSHEHINVQTFVTDLQRELTNSQKVTFVANKGERDEVRNERKEQAMYAREDTQKAPGKEIGADYMMKGTIATILDEAEGTKAMFYQVDLQMVDLESNAKVWFGQKKIKKVIEKKRTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAQ2</accession>
    <name>A0A1W1IAQ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative RNA polymerase sigma factor FecI (Sigma-19)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3951</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3951"/>
    <dbReference type="EnsemblBacteria" id="SLM50118">
        <property type="protein sequence ID" value="SLM50118"/>
        <property type="gene ID" value="NSJP_3951"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3951"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="12"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="112"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="172" mass="20001" checksum="C5E0DCD86D4C63CA" modified="2017-06-07" version="1">MINLTCNEIERLFHEHRFELTRRLCRMVRCEQTAADLAQETYLRLVNLGQTTSVTYPRALLFRTATNLAIDYLRKGKSERQHGETLDHAADVPSSAPSAERAMYDKQRLRVFSRAIDSLPHRSREAFLLHRVHERPYRDIASHLGVSESAVEKLIMRALLHCRTFLRQNDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAQ8</accession>
    <name>A0A1W1IAQ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal RNA large subunit methyltransferase I</fullName>
            <ecNumber evidence="5">2.1.1.191</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rlmI</name>
        <name evidence="5" type="ORF">NSJP_3834</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.191" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3834"/>
    <dbReference type="EnsemblBacteria" id="SLM50001">
        <property type="protein sequence ID" value="SLM50001"/>
        <property type="gene ID" value="NSJP_3834"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3834"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041532">
        <property type="entry name" value="RlmI_PUA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17785">
        <property type="entry name" value="PUA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="10"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM50001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="397" mass="44222" checksum="A30838A01EBD8A33" modified="2017-06-07" version="1">MKISHEQPAAKLMLARRQDRSEPGHYWIYAGFVQPASGDVAAGDLVDVAHPDGRFYARGLYNPASKIRVRILTFQDEPVDDAFWRERIGKAVRLRKRLVSGTDAYRLVYGEADFLPGLIADCYGDVLVLQTLSAGMDRRKQRLAEILCEESGAKRVYVRNDAKSRVLEGLPMETGFLMGGGDTTIEVHEGRARFIVDFARGQKTGWFCDQRQNRLEAATFAPKADVLEVFCHTGAFGIHAALAGAASVEGLDVGEEALASARHHAQLNGVTDRCTYRQADAFEEMRRLDRSGRRYDLVLLDPPAFARSRQAVPRALAGYKDVNLLGMRLTKPEGFLISSSCSHHVSEQDFWQTIRAAARDAGREVRLLAQRGQADDHPILAAMPETRYLKCCIMQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAR4</accession>
    <name>A0A1W1IAR4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50128">
        <property type="protein sequence ID" value="SLM50128"/>
        <property type="gene ID" value="NSJP_3961"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3961"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012099607" evidence="1">
        <location>
            <begin position="29"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="148" mass="15850" checksum="58E40403C469AE5A" modified="2017-06-07" version="1">MNRSTIICAATVLSGVLCGVMVGGPAIAQTKSDKVFHAVATDTKGVDTDVKNVIFYYEEKISETAFVPHEMREVPVKRGTATVKIKFDNIKHIDLKPSGNGTPPHVTITLADGKTGDFILAIAGSFKGQSDFGEVELPAAELKKLTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAW7</accession>
    <name>A0A1W1IAW7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50039">
        <property type="protein sequence ID" value="SLM50039"/>
        <property type="gene ID" value="NSJP_3872"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3872"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="73" mass="7787" checksum="F26646962505A286" modified="2017-06-07" version="1">MRNGKPDVGRRVVITTSRRMEVRGRSCRDGWLIGSGKASKGFGGESMNGNTYCLLPAADGPDSRFDSLNGAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAZ1</accession>
    <name>A0A1W1IAZ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4050"/>
    <dbReference type="EnsemblBacteria" id="SLM50217">
        <property type="protein sequence ID" value="SLM50217"/>
        <property type="gene ID" value="NSJP_4050"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4050"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="297" mass="33541" checksum="7B381E1E0D815968" modified="2017-06-07" version="1">MKLSVIIPCYNAASTIGDLLKALAGETWAEPWEVIVVDNRSDDKSVEVVEQYLGKVPGLRVVKAYERRGKSYARNTGVAAAKGDAIAFCDADDMVGAGWLKAIGTALESMDCVACRVDFTKLNEPSLATQHAYHEQHHGLQKAWYPPYLQHAGGGTLGIKRAIHNQIGGFDEAFPALQDTDYCFRVQLAGYQLFWVSEAVIHVRCRPGSTARFHQIREWALYNVLLSKRHSVDTRKGVVAWKEYVKNWIRLLELLPKVRTKLAWNRWMWYFGWQVGVFHGSLKFHTSPLPLPFRPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB51</accession>
    <name>A0A1W1IB51_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_4038</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4038"/>
    <dbReference type="EnsemblBacteria" id="SLM50205">
        <property type="protein sequence ID" value="SLM50205"/>
        <property type="gene ID" value="NSJP_4038"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4038"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="4"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM50205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="336" mass="37346" checksum="4F91B192F7016674" modified="2017-06-07" version="1">MRILITGGAGFLGSHLSDLLIGKGHDVIVMDNLITGRAENIAHLMGHPRFSFVKYNVCDYIHVDGALDAILHFASPASPQDYLEMPIATMKVGALGTHKVLGLAKAKHARLLLASTSEVYGDPLVNPQPETYWGNVNPISPRGVYDEAKRFAEAMTMAYHRYHGVDTRIVRIFNTYGPRMRPHDGRVVSNFVVQALQGKPLTIFGDGSQTRSFCYVDDLVRGITTLLLIDSDKPVAERTNRARFLTKSTQPLPETIHDPVNIGNPRELTVKGIAELVLKLTGSKSQIEYRPLPADDPKVRRPDIRLAKQLLGWEPEVELEDGLRKTIEYFSQVVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBA3</accession>
    <name>A0A1W1IBA3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_4115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ycf81 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4115"/>
    <dbReference type="EnsemblBacteria" id="SLM50282">
        <property type="protein sequence ID" value="SLM50282"/>
        <property type="gene ID" value="NSJP_4115"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4115"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="3">
        <location>
            <begin position="263"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="341" mass="37117" checksum="7347445F92185797" modified="2017-06-07" version="1">MVPRAIFVLLSALAGTALFVKAEGADASYWLYGFVIGMATAGLIIAGEYALRNLSFGIIIGGTAGLAVGLLLTGLVEWVGGEIFDVQTFLFHISGLVFLLGLPYLGLVIGARFGKEKLPSPEQKFFELSGNTVCPKVLDTSVIIDGRVADLCETGFLEGTFLVPHFILDELQHIADSSDSLKRARGRRGLDILNKVQKMPEVDVRIIDEDFPQVKEVDAKLVVLAKKMNAKIITNDLNLNKVAELQGVRVLNINELCNALRPVVLPGETIRVFVLKEGKEAGQGVAYLDDGTMIVVDNARRHIGKNVDVVVTSVLQTTAGRMIFTRLKEDTEREELQIARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IC34</accession>
    <name>A0A1W1IC34_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ALGX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_4166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; alginate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4166"/>
    <dbReference type="EnsemblBacteria" id="SLM50333">
        <property type="protein sequence ID" value="SLM50333"/>
        <property type="gene ID" value="NSJP_4166"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4166"/>
    <dbReference type="UniPathway" id="UPA00286"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031811">
        <property type="entry name" value="ALGX/ALGJ_SGNH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16822">
        <property type="entry name" value="ALGX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0016">Alginate biosynthesis</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="ALGX" evidence="5">
        <location>
            <begin position="407"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM50333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="548" mass="61397" checksum="14BB20146E50DB99" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZQ6</accession>
    <name>A0A1W1HZQ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46240">
        <property type="protein sequence ID" value="SLM46240"/>
        <property type="gene ID" value="NSJP_0068"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0068"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="59" mass="6452" checksum="8B107F64725F6AE6" modified="2017-06-07" version="1">MGRRRKHDGDLGLASDQIPGQNQNNIRYQALSLSAVAPPGLSQRYGCGLYRTMVSDCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZZ3</accession>
    <name>A0A1W1HZZ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferredoxin-type protein NapG</fullName>
            <ecNumber evidence="5">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">napG</name>
        <name evidence="5" type="ORF">NSJP_0115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.7.99.4" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0115"/>
    <dbReference type="EnsemblBacteria" id="SLM46287">
        <property type="protein sequence ID" value="SLM46287"/>
        <property type="gene ID" value="NSJP_0115"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0115"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="158"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="198" mass="21294" checksum="C9FF019132FBA82C" modified="2017-06-07" version="1">MAIDPKYGRRDFLKDSVLSVAKAAREYSQHAEALPEKVAPAPRTDWLRPPGAVAEPLFLDRCTQCSDCAKACPHGAIVFHQGDGTPIIFPDQAPCMLCEDLPCVAACGTEALVSVPSRDYVRMGTAVVSHRLCTAGQGCHACASKCPTEALSMDFDEQRLLVSGERCVGCGVCEQVCKTVNDHIAIRVTPYRLLSPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I066</accession>
    <name>A0A1W1I066_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0107"/>
    <dbReference type="EnsemblBacteria" id="SLM46279">
        <property type="protein sequence ID" value="SLM46279"/>
        <property type="gene ID" value="NSJP_0107"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0107"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="417" mass="44864" checksum="945DA3B9912CAE57" modified="2017-06-07" version="1">METEVQLALGYIETFAGNGKARSTGDGKRAVKAGIPLPHHAAVDRDERWLYFAESGSDRVRRVDLQEGTLHNFAGIGETCYSGDEGLCGEAGLYLPLDVAFDSRNDLYICDSGSNRIRKVAHDTGIITTVVGTGQHGFNGDGPALDVNLTWPAAIAFDKDDVLYIADTQAHRIRRYDPSSGMVTTIAGTWTAEDDAREQPLVARNLVVLSGDAIGIDFSDDHGWLMPVCSDGLDMSMYLDDGRPALDARLYDVVGIGVDRKGHVIIVDKGSNRVRKVDRETGVISTVAGVCRYGYDGDGKPAVRAMLHAPEAVVLDDEDNLYVSDTMNHRVRRVDAVTGIITTVAGNGDSGYEDKNMGGCGAARFVAKEAAGGLKHGDGLLGVDAVVNSPVGLSLDSRGHLYICERGENKIRRVRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I094</accession>
    <name>A0A1W1I094_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type polysaccharide/polyol phosphate transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_0253</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46425">
        <property type="protein sequence ID" value="SLM46425"/>
        <property type="gene ID" value="NSJP_0253"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0253"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10147">
        <property type="entry name" value="Wzt_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029439">
        <property type="entry name" value="Wzt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14524">
        <property type="entry name" value="Wzt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="68"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="425" mass="47388" checksum="DC2FA648EA702EEB" modified="2017-06-07" version="1">MMKHDASIRVEGLWKRYGLPIAPAFHRFVKRLTGDRPDHERPEQEEGPWALRDVSFEVKRGETLGIIGRNGAGKSTLLKILAGVTPPTRGRVEVRGRVFSMIELNAGIHPELTGRENVYLLGAIMGLSRGEMNEALPVIEEFIELERWFDRPVRTYSSGMLARLGFGVATSIRSDVLLIDETFSVGDLRFQNKGLARIKTMRDEGAAILLVTHSLDMLQLVALKGIVLHEGRIIAEGSVHDGLRAYEQLVFHSEAEGILRRSRRISTNEFTLFAARVFDANDSTVTEVEAGVPFGVEIECTVHRTLEQPVFSVGILNAAGVVCVWNVSDEDGLMASRSEGCFRLRVWYPDNALAKGAYEVNFSLREKTSYETLERVTGVTGFSVTCHGRARGIVRVAARWSLTRLLPTESHECREWTTVIGDSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0E1</accession>
    <name>A0A1W1I0E1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Soluble hydrogenase, small subunit</fullName>
            <ecNumber evidence="7">1.12.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_0265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="1.12.-.-" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0265"/>
    <dbReference type="EnsemblBacteria" id="SLM46437">
        <property type="protein sequence ID" value="SLM46437"/>
        <property type="gene ID" value="NSJP_0265"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0265"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="6">
        <location>
            <begin position="5"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM46437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="380" mass="40966" checksum="93479935DE868AA1" modified="2017-06-07" version="1">MIKRYLLAPGPTPVPPEVLLAMARPMIHHRAPEFDKLFGEVRDGLKWLFQTNGDVLMLAASGTGGMEASVSNFLSPGDKALTINGGKFGERWGKLCKTYGAQVTELKVEWGRAIDPQLVADSLKKDPGIKAVYVQASETSTGVAHDIKTLAQIVKGHPDTILVVDAITALGVFDIKTDEWGIDVVVTGSQKALMLPPGLAFVSVSEKAWRLAEKAKNASFYFNLKKERENQQKSQTAYTPAVSLIIGLQEVLKMLKAEGLEQVFGRQANLAMAMREGMKAAGLALLPKESPSDALTAVLAPEGVDGQAIYKNLRVQYGITAAGGQDHLKGKIFRLSHMGYMDRFDVIMAVAATEMVLKGLGHPVKLGSGVAKAQEILMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0I8</accession>
    <name>A0A1W1I0I8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative D-alanyl-D-alanine carboxypeptidase</fullName>
            <ecNumber evidence="11">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_0344</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="11"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0344"/>
    <dbReference type="EnsemblBacteria" id="SLM46516">
        <property type="protein sequence ID" value="SLM46516"/>
        <property type="gene ID" value="NSJP_0344"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0344"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012732221" evidence="9">
        <location>
            <begin position="21"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="10">
        <location>
            <begin position="38"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM46516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="282" mass="30397" checksum="0C137B8118C0586D" modified="2017-06-07" version="1">MEWRFLVGSLSAALVMTAGAAWPCAAFEQDARAGPPDRPAVHASALYLVELGSGRVLFEKDAARRLPPASLTKIMTALVALETASPDQVVQVDGRALVHRSSLKLHAGEQFLLRDLLTAMLVTSANDACEAVAWHVGGDADRFVMMMNERARALGLADTHFVNACGFDAPGHFSTAADLAALTGKALQAPEFSMMVRTVVREISSVDGKRQVSLHSTNELLLDPDVNGVKTGYTSKAGRCLIASMFKDGHRLLLVGMNVTDRWEQATRLLRYGHAVLQQSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0J8</accession>
    <name>A0A1W1I0J8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46373">
        <property type="protein sequence ID" value="SLM46373"/>
        <property type="gene ID" value="NSJP_0201"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0201"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="122" mass="13655" checksum="8C3BFCB3158B9C09" modified="2017-06-07" version="1">MVREQLMSLHGALIVAEQSSYEGVIGPVGSVETLLDLLQCNPWFTWLHPFSDLLVRLDHLLDDDTFEISEDNLAHLLGELEGLLRPSIAGDGFARAYFEALQRNSDVVLAHFRLKRLLPDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0M0</accession>
    <name>A0A1W1I0M0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46548">
        <property type="protein sequence ID" value="SLM46548"/>
        <property type="gene ID" value="NSJP_0376"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0376"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="59" mass="6572" checksum="1902E17875D00DBA" modified="2017-06-07" version="1">MTTSQAAELRVKWKQHIDAPACEHLNLELEWSDNGYLTGNYNCIVCGHPVLSGANNRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0N6</accession>
    <name>A0A1W1I0N6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46537">
        <property type="protein sequence ID" value="SLM46537"/>
        <property type="gene ID" value="NSJP_0365"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0365"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031877">
        <property type="entry name" value="SmbP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16785">
        <property type="entry name" value="SMBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="284" mass="30334" checksum="15E212F094D7C3DB" modified="2017-06-07" version="1">MAHGNGITGPTPVGGAILTLGLAVGLAACASPSHTRTASPTPVEQQVVVERPVVPTERTSGVAERPMPPDRIVPRAATGMQTAATVCATHLDAQGNRIYDDPLCPTRDSRTTETTPDVQDPAYYNRHINSAVDHVRRAEVAGDQGNIPDMLRHTDLSLSHATAAQRAVDDASLNDGIMDLRETMILGQRNHIAPAALRDARVKLTQAAHAHPVAARTGTVTGELKRTSTPARADGSEYYVVRDRQRGDTPVVLSPDLSRQVQDGDMVEMQLDAQGRVLAVSKYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0V0</accession>
    <name>A0A1W1I0V0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46626">
        <property type="protein sequence ID" value="SLM46626"/>
        <property type="gene ID" value="NSJP_0454"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0454"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="347" mass="37635" checksum="90B123FEA0C8C21A" modified="2017-06-07" version="1">MPLQILVRGVVQIDAGLLRPLDERPFPFVPSGIAVVTTRDAGFSAVVGGEKAHWQRPEKGRDTRLIIEASTGRAKCVPLSSTVIVVGKIGVRRQDQEYPGLGGRTWRAHDEEAFPVAIGSVHGHVIEAGLPFGRHVKRQSTASLAVPPAAGFGRIGRNGLWLHPDRPRPDHFPSRPKSVDCKHRSDPALGRHEEGHPFTGFITSPAGVPLDERTASVHPGDRGTCGGLRRFGAGSEDRRSRERQAGQAEAGREKLAPTPPLAGHDGRCPDEAMGIESIVLCLPPVDPPFADTQMHGSDVEFLFQLVEHVVADRPVVAQIDQGHSLCRQDFMVETLKGFDRIARPLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0V8</accession>
    <name>A0A1W1I0V8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46636">
        <property type="protein sequence ID" value="SLM46636"/>
        <property type="gene ID" value="NSJP_0464"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0464"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="144" mass="16499" checksum="F3BDC32795027C51" modified="2017-06-07" version="1">MVTDFFEQHRVRIEQAIRQPGLRHSSVRVSAAPKDEGERRREPRVEQWQPCSYEASESPGEFSSTTQVGETVALDHSQEGILLLMDRAPIPTKMLEVHTSQGLGRKTLLVFDVRWVKPVQVPSVGEYFLVGCRRTFGPYHYVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I140</accession>
    <name>A0A1W1I140_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative dioxygenase VC_1345</fullName>
            <ecNumber evidence="4">1.13.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.-.-" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0540"/>
    <dbReference type="EnsemblBacteria" id="SLM46712">
        <property type="protein sequence ID" value="SLM46712"/>
        <property type="gene ID" value="NSJP_0540"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0540"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="PTHR11056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="368" mass="40829" checksum="4A90B589338F39AE" modified="2017-06-07" version="1">MYLNKKGKVPNQAHVGIPEGICEEEHGRAGFAGPASHLYRSHPPTGWLKVDGPLKPRAFACNRLCTADRPAATQPALIMQSQDVSLYASARTETMTHFVRNADGDEVHFTHQGMGRFETDYGTLSYEPGDYIVIPKGTTYRIHVDAGPSFFLIVETPESITVPDRGPLGHHALFDLGVLVAPELGAAEPSDAEGQEWEVRIKRQGNSTLVVYPFYPMDVVGWKGDLWAAKLNVRDFRPVTSPRYHLPPSVHGTFRAGGCLISTFAPRPLESDPEALRVPFYHRNTDYDEVLFYHQGDFFSRAGIQPGMLTLHPQGIHHGPQPQAVQASKGKTQTNEVAVMIESKAPFTVRAEMESVEVKDYALSWSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I168</accession>
    <name>A0A1W1I168_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Co-chaperone protein HscB (Hsc20)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hscB</name>
        <name evidence="3" type="ORF">NSJP_0574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0574"/>
    <dbReference type="EnsemblBacteria" id="SLM46746">
        <property type="protein sequence ID" value="SLM46746"/>
        <property type="gene ID" value="NSJP_0574"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0574"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="PTHR14021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="33"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="223" mass="25921" checksum="B94EDAFB9F253D4C" modified="2017-06-07" version="1">MARSMCWHCQSEVSGEYFCERCVKVQPVSKDADYFTCMGFPRRLNLDVQKLEAAFYELSRAFHPDFYQTKSETEQAISLDNAATLNTAYRTLRDPIQRAEYLLSLEAGSVKDIRTSPPADLFEEILELQDTLDEYRAADRASEAAQRLRPILQSEQHKLEERSKAVESQLRKLFTQWDQLQDRGEATSESRSERERLLKEMRDLLSHRTYIGNIVRDLVATIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1F5</accession>
    <name>A0A1W1I1F5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_0674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0674"/>
    <dbReference type="EnsemblBacteria" id="SLM46846">
        <property type="protein sequence ID" value="SLM46846"/>
        <property type="gene ID" value="NSJP_0674"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0674"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="46"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM46846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="282" mass="31093" checksum="CDF4759185C33E15" modified="2017-06-07" version="1">MTGGLRRTNARWSSMAAIVVTVCTGAPWLVMAELPATPQELDPVPMISIPAGQFLMGNPEGTGRADEWPQRSVYLDAFAIDQVEVTNERYRAFVVATGHRDPPNPYGTGPLTSIQGIGELPVVQTTWYDAKAYCGWAKKRLPTEAEWEKAARGTDGRRFPWGDEPPTSKRANFDREWADERTLHPVGSLPEGDSPYGVKDLAGNAREWVSDWYDPDYYRHAPTKNPQGPDKKGVVRAIRGGSWHSPLADITTSARGRGGFALQTHGTGFRCVRSLEGDALKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1G2</accession>
    <name>A0A1W1I1G2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipid A biosynthesis acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_0663</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0663"/>
    <dbReference type="EnsemblBacteria" id="SLM46835">
        <property type="protein sequence ID" value="SLM46835"/>
        <property type="gene ID" value="NSJP_0663"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0663"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014548">
        <property type="entry name" value="Ac_Trasf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028561">
        <property type="entry name" value="Ac_Trasf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM46835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="306" mass="35462" checksum="DAA8AD976E6D4E15" modified="2017-06-07" version="1">MSEEWLGRPERGSLVLLRLLTWFSLRIGRPLSRLLLYPICLYFVVFSRGTSLISRRYLERVLGRHVQWTDIFLHYHTFASTIHDRVYLLSGQHRWFDVKTEGTEIVESLLDRKCGFILMGSHLGSFEVLRAKGLLERHLPIHVVMHEGAASNLNSVLHGLCAGIRDRIIQPGRPDTMLKVKECLDKGEVVGILADRVLSGEKTVNCSFLGASTVFPEGPFLLAGMLQVPVVLFFGFYEGGRQYRIRFEPFAEAIHWDRARRAEASVEWVRQYAKRLEYYCLRYPYNWFNFYELSDRTTDSDMPARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1U4</accession>
    <name>A0A1W1I1U4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_0808</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0808"/>
    <dbReference type="EnsemblBacteria" id="SLM46980">
        <property type="protein sequence ID" value="SLM46980"/>
        <property type="gene ID" value="NSJP_0808"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0808"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012506522" description="FGE-sulfatase domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="3">
        <location>
            <begin position="34"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM46980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="271" mass="30241" checksum="6266FE7741085E65" modified="2017-06-07" version="1">MWGSLSLLIAAIVLGLPPAIRAADAVPPGSDGAPMVKVPAGPFPMGVPPGDRDGGRDEYPRHEVSLDTYEIDLYEVTNARYQAFVKSTAHRVPQNPNNPTRNLWQGETVSDTLADRPVVNVDWADADAYCRWAGKRLPTEAEWEKAAKGNTDHRFPWGNVEPTNKHLNFNQKWIGEKTLMPVGSYEAGKSPYGAYDMAGNVWEWVHDWYDPRYYEKSPGKNPKGPDSGTKRVLRGSGWQNETPTVRIFTRVESDPTVRNESTGFRCARDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I236</accession>
    <name>A0A1W1I236_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0882"/>
    <dbReference type="EnsemblBacteria" id="SLM47054">
        <property type="protein sequence ID" value="SLM47054"/>
        <property type="gene ID" value="NSJP_0882"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0882"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011101">
        <property type="entry name" value="DUF5131"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07505">
        <property type="entry name" value="DUF5131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="239" mass="27161" checksum="5BFA4423AF3EFD83" modified="2017-06-07" version="1">MAGLSKIEWTEATWNPVTGCDKISPGCKNCYAERLALRLQAAGTRQYKDGFALTLHPESLGIPLGWKKPKVIFVNSMSDLFHRDVPVEFISRVFAVMQIASQHQFQVLTKRADRLVELDSQLSWPDNVWMGVSVENEDYVLRIRHLKQTSARIKFLSLEPLLGPLPNLDLKGIDWVIVGGESGPYARPMKPQWVRQIRAQCISANVPFFFKQWGGVFKSKTGRTLDGRTWDQMPKVEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I237</accession>
    <name>A0A1W1I237_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_0896</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47068">
        <property type="protein sequence ID" value="SLM47068"/>
        <property type="gene ID" value="NSJP_0896"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0896"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="200" mass="21463" checksum="AD5D190D6D07CA8E" modified="2017-06-07" version="1">MSEAEEHRRRIDVLAIGLFGLAVGALTLGVAQVGGIPESNQVGTLVIALIFGGVVQILAGITDIRYHEQLGGTALTMYGFFWLTVCSAKLVSESTSFHLDMVLYAPINFVYAAFSAVMVYLTAYRNATLCMLHFVITITFSSTVLVQLGLLTETPPGLLHIIVGLMAFYHAVASLTQAFTGRQLVPLGPALLHQRGALPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I241</accession>
    <name>A0A1W1I241_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0895"/>
    <dbReference type="EnsemblBacteria" id="SLM47067">
        <property type="protein sequence ID" value="SLM47067"/>
        <property type="gene ID" value="NSJP_0895"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0895"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011460">
        <property type="entry name" value="DUF1566"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07603">
        <property type="entry name" value="DUF1566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="161" mass="17857" checksum="E9CBC12D51B2B020" modified="2017-06-07" version="1">MNKRVRVHIASILAGAGCAVVLWSPGSLAEQSAARFTLVLEGAAVKDASTGLIWEQDPDREHDVWSRSIERCKAKEVGGRHTWRAPSVDELKSLIDQSQHDPALPPGHPFSNIKSEIYWTATPDPKDDIVAWQVSFFSGEPVTDQKSGTRRMWCVLDEPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2D3</accession>
    <name>A0A1W1I2D3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">S5A_REDUCTASE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_0982</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0982"/>
    <dbReference type="EnsemblBacteria" id="SLM47154">
        <property type="protein sequence ID" value="SLM47154"/>
        <property type="gene ID" value="NSJP_0982"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0982"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="DUF1295"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="PTHR32251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="S5A_REDUCTASE" evidence="6">
        <location>
            <begin position="145"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="268" mass="30273" checksum="18C94C2C47A17FE7" modified="2017-06-07" version="1">MASDPHTLVFTAYLTMAGVMAGLWMLQLLHRNASLADVGWCAGLIATVCWYAAQASGDAERKMLAVVMVSVYAGRLGIHLLFDRLIGKAEDARYRRLRAEWGRAERLKMFGYFHLQAAAVALFSLPFLVLTQNPRPPFGLIEVVGAIVWIVAVGGEAVADRQLAAFRAKPANRSRVCREGLWYYSRHPNYFFEWLHWWAYVVMTIGSPGWLLTWLAPLGMGWALVKFTGIPPAEQQALERRGDEYRIYQKTTSALVPWFPRPWPTSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2G2</accession>
    <name>A0A1W1I2G2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0887"/>
    <dbReference type="EnsemblBacteria" id="SLM47059">
        <property type="protein sequence ID" value="SLM47059"/>
        <property type="gene ID" value="NSJP_0887"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0887"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011486">
        <property type="entry name" value="BBP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07642">
        <property type="entry name" value="BBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="417" mass="47142" checksum="21680FFFD1C00FB5" modified="2017-06-07" version="1">MEIGVIVRAGTIVDLLKISALSTVICILAWRADVLTAGAEQPPPVSIPQTESKADQRDEEPRSLWHYGLYLDLSYAVDFNFPENHLWRSKVTTQRVNDPNINMALAYVRKDANEASRWGMELALQTGRDVTGEVPNASLRFGDPYPNADTFSHFSRANVSYLAPVGTGLTLTAGLFNSFIGYDSFYAKDNFNYTRSYLADNSPYFMFGVAAQYQFGEAVKTAFYVINRYNFLSYPNNLPSYGTQVKWNASSQLTVIQNLYYGPDQSNTQMKYWRFFSDSILEWKRHAFTVALAYDIGTEQSIPEAGGRQAFWTGGAIWGHWQLARPWAVAVRPELYYDPDGTLTGAKQFIKAVTTTLEYRWYYAWTTTIFRLEYRFDNSTGPQGGFYTGGQIAPGVIGLTPSQNLLFFSALWSFDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2I9</accession>
    <name>A0A1W1I2I9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47207">
        <property type="protein sequence ID" value="SLM47207"/>
        <property type="gene ID" value="NSJP_1035"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1035"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="105" mass="11799" checksum="441C750E9F6D42B9" modified="2017-06-07" version="1">MLKITEQRVEESESMLLVLEGRLVGPWVGEVDTCWNRMAPEQQKRTVIDLSSVTFVDGEGKALLTRMWKTGATLRATGCLMRCLVEEITGVEQRKASCKMDEHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2P0</accession>
    <name>A0A1W1I2P0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Superoxide dismutase copper/zinc binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1092"/>
    <dbReference type="EnsemblBacteria" id="SLM47264">
        <property type="protein sequence ID" value="SLM47264"/>
        <property type="gene ID" value="NSJP_1092"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1092"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="SSF49329"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Cu" evidence="2">
        <location>
            <begin position="72"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="222" mass="23631" checksum="90C04F45546D3C90" modified="2017-06-07" version="1">MRYERQKDPTSMDASQSPASVFESRKEDTMNVKTTGTAVAIGLLLGGCAHHHTGKLEQKLHAKAAIAGHGITGEAHLYQEYEGRIRIKLKLEGTADSALTPGRHALHIHETGACDPFTAAKGHYDGTVDPQVNPEASVAPGLGNHPYHLGDLPNIVIDDGRKGRLYTITSRVTLSPGLTTLLDADGSAIVIHGLEDKFLPDPPTKDAPGGPRIACGVITLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2U1</accession>
    <name>A0A1W1I2U1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47312">
        <property type="protein sequence ID" value="SLM47312"/>
        <property type="gene ID" value="NSJP_1140"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1140"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="77" mass="8530" checksum="DF0C5A8A6BE2455B" modified="2017-06-07" version="1">MQRTIEVVENFETAASFTIHAGVSSSKRCGARQGPRSERKSLPPIGRYALYIGGKHKDCHKYESTEILQLTSDHPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2W2</accession>
    <name>A0A1W1I2W2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MpsC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47163">
        <property type="protein sequence ID" value="SLM47163"/>
        <property type="gene ID" value="NSJP_0991"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0991"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018745">
        <property type="entry name" value="MpsC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10057">
        <property type="entry name" value="MpsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MpsC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="114" mass="12807" checksum="FB9F1ED369EF11ED" modified="2017-06-07" version="1">MENALRNAIIKFEQEFMGRGPDDVRAFIVRDLVVVRLKGVLTPAERQLAKTPEGVDMVKRIRQTLIAQGRDKLCEQVSDITGAKIIGLFTDIDVPLGERVFVFTADRDIQIGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I313</accession>
    <name>A0A1W1I313_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1225"/>
    <dbReference type="EnsemblBacteria" id="SLM47397">
        <property type="protein sequence ID" value="SLM47397"/>
        <property type="gene ID" value="NSJP_1225"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1225"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="316"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="644" mass="70921" checksum="4EC837FD618349CF" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I335</accession>
    <name>A0A1W1I335_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1248"/>
    <dbReference type="EnsemblBacteria" id="SLM47420">
        <property type="protein sequence ID" value="SLM47420"/>
        <property type="gene ID" value="NSJP_1248"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1248"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024524">
        <property type="entry name" value="DUF3800"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12686">
        <property type="entry name" value="DUF3800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="374" mass="42165" checksum="313083556B2D4744" modified="2017-06-07" version="1">MDIEEIRDAHIGMYGLSNADQPYTFYHDETNNIKKLRLDAQGLNIAEPAIFVLGGIVHSGTPRPLDIRSLRDVMRIQTSADEIKLKHVAKGEFLDLLKSEKLTTFLKWISDSGLMVHYHALDPLYCSLVDIMDSVLYRLEEPRLVELHAVLKADLATLLRANLPATTDIFFRYSYPDLTPENRKPFLDELLRLVEGSDGVLPEFNAMMLKGMLQAGRNLPSLDFIEGFTPYLLIKSFGAIYLTRIAIFKHSSHILDMEDSIRDEIEAIRPTSNGVPITHYRFADSKSEPGIQVSDIVVGLIGKMHSYFAQNSREVISQTRVSLTGASLKNAELLRNLIDASHEANIAFLHHVSSMDDIDKMNLFLRTSGSSYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I340</accession>
    <name>A0A1W1I340_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1127"/>
    <dbReference type="EnsemblBacteria" id="SLM47299">
        <property type="protein sequence ID" value="SLM47299"/>
        <property type="gene ID" value="NSJP_1127"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1127"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="40"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="105"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="194" mass="21190" checksum="B08336DFE460A3D4" modified="2017-06-07" version="1">MENMDRMTSRRRRGGLYLESTEAEQLGVLPGEERRVKDVMDRHLAVIPPASDLAQATEVMQQRQVTSLIVGEESAPMGLLTDRDLAMQLTRAEPQRARTVGEVIAGRQTLVCHEDDILGDALSAMKDRQLSSLPVVNGRGIVVGMLSPLEVASAAVPTVTPAWTEGMRQPETMSDQRGQRKGGDDEGRTVHPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I394</accession>
    <name>A0A1W1I394_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit I</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">nuoI</name>
        <name evidence="7" type="ORF">NSJP_1304</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1304"/>
    <dbReference type="EnsemblBacteria" id="SLM47476">
        <property type="protein sequence ID" value="SLM47476"/>
        <property type="gene ID" value="NSJP_1304"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1304"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="195" mass="22750" checksum="0DBEC3CF4DD7B8D1" modified="2017-06-07" version="1">MSVGTLTKKVLQAALFYEIWDAMKVTFKHMFHKPITFQYPREQRTIPDTHRGALGLLRYDDGRERCVGCDLCEAACPSRCIKVISAEDAERPLQRYASEFYIDITKCVFCGYCVEACPVNALAMTKVYEFSTHDKRTLMFDKKRLYDIGERHLDDAKKYLYAHNQEKNVEESREYRYYFPQSVAKATQSTPKHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3F2</accession>
    <name>A0A1W1I3F2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose pyrophosphorylase</fullName>
            <shortName evidence="9">ADPGlc PPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">glgC</name>
        <name evidence="11" type="ORF">NSJP_1201</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1201"/>
    <dbReference type="EnsemblBacteria" id="SLM47373">
        <property type="protein sequence ID" value="SLM47373"/>
        <property type="gene ID" value="NSJP_1201"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1201"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00624">
        <property type="entry name" value="GlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023049">
        <property type="entry name" value="GlgC_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="10">
        <location>
            <begin position="8"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha-D-glucose 1-phosphate binding" evidence="9">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM47373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="413" mass="46038" checksum="77F284FC35FC0E4E" modified="2017-06-07" version="1">MKSTRVLGMIMAGGKGSRLLPLTEVRSKPAVPFGGTYRIVDFVLSNFVNSGITALHVLVQYRSQSLIEHLRNAWQIGGRSKDNFVSVVPPQMRAREGWYEGTADAIYQNLNLIADFRPDIIAVFGADHIYRMDIGQMVRRHLETEADVTVAVLPVPVKEATGFGIVETEESGRVVGFQEKPAHPKPMPTRSDYALSSMGNYLFNTETLVPLLKRDASRQGPHDFGRNIVPDLLANYVVHAYDLSCNDIPGLRPYEEHAYWRDVGTLDAYWQANMDLLGETPILDLRNADWPIVSGRYDGPLPSLIRSRIDDSMIGQSSQCVDAEIRRSVIGRGVRIERGARIEECVLLDDVHVGPHTRLRRVIADRGAVIPGQTRLGYERERDAAHFHVSESGLVVVPHPSIDMEPGSLRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3L4</accession>
    <name>A0A1W1I3L4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan-binding domain 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1261"/>
    <dbReference type="EnsemblBacteria" id="SLM47433">
        <property type="protein sequence ID" value="SLM47433"/>
        <property type="gene ID" value="NSJP_1261"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1261"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="35"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C51" evidence="2">
        <location>
            <begin position="153"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="278" mass="29621" checksum="3001D9F82E499AF0" modified="2017-06-07" version="1">MATRHRTSSGRGNVGRNAGRAYPGHIIKVGIKDNASVRAVQQRLNEVGCGPLLVSGDFNSSTRSAVRLFQARTVDGQGQALKVDSVVGPLTWTALFGQQALPAITDQPISLLLKACLNIAASQVGVMEDPAGSNRGPQVDEYIRSVRLDPSAGSYPWCAAFVYWSFERAAARVGIANPVVCTAGVLDHWKKAAKAGARLILPEELLDDLSLLKPGLIFTMSTGGGNGHMGLVEGFRDDRLITIEGNTNLSGGREGIGVFRRTGRKVSEITKGFISYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3N4</accession>
    <name>A0A1W1I3N4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47610">
        <property type="protein sequence ID" value="SLM47610"/>
        <property type="gene ID" value="NSJP_1438"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1438"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="65" mass="7472" checksum="51DD957AF8C3613E" modified="2017-06-07" version="1">MHYVRIGKRALNLDSIAYCEVQAWQDEMSVKVYFAGSANNTPLVFGEGEAKELWKYLEYIAEKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3N5</accession>
    <name>A0A1W1I3N5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47453">
        <property type="protein sequence ID" value="SLM47453"/>
        <property type="gene ID" value="NSJP_1281"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1281"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="163" mass="17341" checksum="A81E6A3931B7FF2F" modified="2017-06-07" version="1">MRTAARSAIIIGFILSGLVCFDGCPSVRAETLSILNTGNKMEGILVEAAMKRQLRDEGHTVTDETMEGYLLIVGVLPNITLGGEKRGVIGNIVVSSVSAPVSGNAAGTDQCHKEPERAQRITDVVGAKVLYINSTLAQAPNEESLADILSTFAKREIRTTAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Q6</accession>
    <name>A0A1W1I3Q6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH:ubiquinone oxidoreductase, membrane subunit L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nuoL</name>
        <name evidence="9" type="ORF">NSJP_1301</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1301"/>
    <dbReference type="EnsemblBacteria" id="SLM47473">
        <property type="protein sequence ID" value="SLM47473"/>
        <property type="gene ID" value="NSJP_1301"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1301"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="8">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="135"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="654" mass="71307" checksum="C538B9707D9A2469" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3U2</accession>
    <name>A0A1W1I3U2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (adenine(58)-N(1))-methyltransferase TrmI</fullName>
            <ecNumber evidence="4">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trmI</name>
        <name evidence="6" type="ORF">NSJP_1498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer composed of a dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1498"/>
    <dbReference type="EnsemblBacteria" id="SLM47670">
        <property type="protein sequence ID" value="SLM47670"/>
        <property type="gene ID" value="NSJP_1498"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1498"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM47670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="288" mass="31717" checksum="0461E7F6A2812476" modified="2017-06-07" version="1">MITLCHGERIHLVDKKGRHYALTLKAGETYQFSGQTIPHDELIGKADGTLVTLSGGKAMLALRPTFGEYVLKMPRGAQVLYPKDLALITMWADIYPGARVFEAGTGSGALTMALLRAVGHRGLVVTYEAREDFSRTALMNIERYMGVAPNLVPLRRNAYEGIDLPEDRLPFDRVVLDLPEPWQVVSHAASVLRSGGIFLSFVPTVPQVQRTVEALERAAVFGMPETFETLLRTWSIQGRSVRPDHRMVAHSGFLTVARKVDPGFCGGAEVPCHDGVDQDERADHEDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3Z8</accession>
    <name>A0A1W1I3Z8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1381"/>
    <dbReference type="EnsemblBacteria" id="SLM47553">
        <property type="protein sequence ID" value="SLM47553"/>
        <property type="gene ID" value="NSJP_1381"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1381"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="96" mass="10714" checksum="2FF960739EA5983B" modified="2017-06-07" version="1">MTEEKGGRRAARLDKELLSILCCPETKLDVTLADQVLIDRINDAVGRGTLKNRGKKPVTELLDGGLVRADRKLLYPIREDIPVMLIEEAIPLDEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I413</accession>
    <name>A0A1W1I413_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47609">
        <property type="protein sequence ID" value="SLM47609"/>
        <property type="gene ID" value="NSJP_1437"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1437"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="4"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="112" mass="12409" checksum="B55B8D1B1C229477" modified="2017-06-07" version="1">MKLRYCTRVDTRLPVVFAGESFVGEGTVLNLSVPGCAITSKKAVRSGSYLELKVLFPDQTPPLSVGLARVRWCQGRYFGVEFIRMPGTDQVRLGRLIRNPVVEKPGVSRAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I461</accession>
    <name>A0A1W1I461_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47765">
        <property type="protein sequence ID" value="SLM47765"/>
        <property type="gene ID" value="NSJP_1593"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1593"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="129" mass="14390" checksum="5E56414362BB9BE4" modified="2017-06-07" version="1">MTALSVVGFSTHRLIFPRRAAPLRHKSPSFTIPTVFEPAFLSCPVTRPLPVSLCSDIFFKKSGVHARLALSLRVMNRDLRIDQMVVARSQPGGDVAIYGSPCIPEMVGAIMPLLLHWIGLSTVWFFWQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I487</accession>
    <name>A0A1W1I487_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_1644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1644"/>
    <dbReference type="EnsemblBacteria" id="SLM47816">
        <property type="protein sequence ID" value="SLM47816"/>
        <property type="gene ID" value="NSJP_1644"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1644"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="117"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="260"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="781" mass="86514" checksum="3E04BB084C0BB4AA" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4L8</accession>
    <name>A0A1W1I4L8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47967">
        <property type="protein sequence ID" value="SLM47967"/>
        <property type="gene ID" value="NSJP_1795"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1795"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="138" mass="14695" checksum="EC5418125A4F4D2E" modified="2017-06-07" version="1">MGLSTMVSVYTFNQKESCLFEGFQEGLFRKGTLAVQTGHEVNGFTDGHGDPEIQADPAMIAGGTGDLLQPVGHIRLGAQIEFHVCIDRKAIEAFLAHPAPFTVGLHEALVDAEAGPLADRTLHGGQPGFDVRNGEMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4M7</accession>
    <name>A0A1W1I4M7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">sucC</name>
        <name evidence="9" type="ORF">NSJP_1805</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1805"/>
    <dbReference type="EnsemblBacteria" id="SLM47977">
        <property type="protein sequence ID" value="SLM47977"/>
        <property type="gene ID" value="NSJP_1805"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1805"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="9"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="324"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="53"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM47977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="392" mass="42033" checksum="9A4BEFE39E50A63C" modified="2017-06-07" version="1">MNVHEFQAKSIFAQFGVPVPRGKEITSPAAATAWADELNTPMFVVKAQIHAGGRGKAGGVKITKDKGAVAGLAKELIGKTLVTHQTGPKGRTVHRLLVEEGANIGKELYLSILVDRETGRPTFIASTEGGMEIEEVAEKTPDRIIKESIDPAAGFQAHNGRNVAYALGLHTLEPAVITPFIQLLGNLYRLFMEKHAALVEINPLIITKEKTLVALDGKVSFDDNGLFKHEDVQKMRDLNEEEPLEIEATANNLNYVKLDGNIGCMVNGAGLAMATMDVIKLAGSEPANFLDVGGGATKDTVAAGFRILLKDPNVKGIFINIFGGIVRCERIAHGVIEAAKEVKITVPLVVRLQGTNAEEGRKLLAESGLKLDVANDLWEAAQKIVQLTGKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4T0</accession>
    <name>A0A1W1I4T0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47985">
        <property type="protein sequence ID" value="SLM47985"/>
        <property type="gene ID" value="NSJP_1813"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1813"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="72" mass="8576" checksum="CB2EC24AB85C91C7" modified="2017-06-07" version="1">MFRELQLQKRTDIDKQFKDFRPMKIVMDRRTAGPVSIWILEGIRKDSPFILFNLPVSLFRDSPPHRDRKGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Y2</accession>
    <name>A0A1W1I4Y2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48087">
        <property type="protein sequence ID" value="SLM48087"/>
        <property type="gene ID" value="NSJP_1915"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1915"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mrr_cat" evidence="1">
        <location>
            <begin position="254"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="396" mass="44918" checksum="F20A590B8AE38616" modified="2017-06-07" version="1">MADSTLNDTLRHFEAAEANLGKAEKVLCDIESAIPEGIVFGVNPEYEANCRSFNVLLSALPKIDGWKPTIAILELDEIAQNRLDALELGEVSCINNVEREIGAPTRQLREYRYRFNQKRRELIRDALIELIDAIDGNLRKLGKLLDEESPLNETIADPEFEQIKENAAQISALLGSSVPMPARWSDLHRHLHFGMLGDLQDIIKHDWPSVKAGLRKSLYGEREPVPVDVEDLGALVSKKPRGRVVTKLLWMHLTDEDFERLIFALISSEQQYENPEWLMKTNAPDRGRDLSVYRVYSDPLAGAVRHRVIIQCKHWQSKSVGPSEIATLKEQMKLWEPPRVDVHVIATSGRFSSDAVSIIERQNRSDSALRIEMWPESHLELLLASRPAIIAEFGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I522</accession>
    <name>A0A1W1I522_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NSJP_1849</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1849"/>
    <dbReference type="EnsemblBacteria" id="SLM48021">
        <property type="protein sequence ID" value="SLM48021"/>
        <property type="gene ID" value="NSJP_1849"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1849"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012980886" evidence="13">
        <location>
            <begin position="25"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SLM48021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="567" mass="63270" checksum="6D38D1EE0480469C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I538</accession>
    <name>A0A1W1I538_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Acyl carrier protein</fullName>
            <shortName evidence="8">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">acpP</name>
        <name evidence="12" type="ORF">NSJP_1771</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8 10">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1771"/>
    <dbReference type="EnsemblBacteria" id="SLM47943">
        <property type="protein sequence ID" value="SLM47943"/>
        <property type="gene ID" value="NSJP_1771"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1771"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 8 9" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8 9">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM47943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="77" mass="8472" checksum="3328E327124E6E93" modified="2017-06-07" version="1">MATVDERVKKIIAEQLGVEEDEVTSEASFVEDLGADSLDTVELVMALEEEFGIEIPDEDAEKILTVGKALDYIKEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I548</accession>
    <name>A0A1W1I548_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1948"/>
    <dbReference type="EnsemblBacteria" id="SLM48120">
        <property type="protein sequence ID" value="SLM48120"/>
        <property type="gene ID" value="NSJP_1948"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1948"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="140"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="366" mass="41367" checksum="B17A685E3B37F161" modified="2017-06-07" version="1">MITLTSPSSSRLDRVIDVACLICGRAQIDVLASTADIQFQFRILNAFHRRRRIESHPDQLADRTRFTQDYSAQIVQCRTCGFIYRNPRPVATTITSTYAKDHYSAAHLQAEFDAQRSWAKHKASRLARWLPVKRTPSIIEVGSFVGGFLAAAQEHGWTVLGVDPGKQVAEFCLARGLPVHCGTLADAPIASQSVDAVVIWNTFDQLPDPDITLESARQMLRTDGILVIRVPNGLLYRHAVKSLKRNGLWRHILIATLAWNNLLGFPYLHGYSVGTLDRLLGRHGFRRRGVYGDALLPLADRHTKLWARWEEHMVKWGCRLLAAQPFQPASQWYPWMDLYYGLSGPIQTNMPPQESRGQLASFVSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5F8</accession>
    <name>A0A1W1I5F8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1892"/>
    <dbReference type="EnsemblBacteria" id="SLM48063">
        <property type="protein sequence ID" value="SLM48063"/>
        <property type="gene ID" value="NSJP_1892"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1892"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="88" mass="10337" checksum="AD244BB370C165C0" modified="2017-06-07" version="1">MSFNDWTLLGRIRKTFNQRCAFLGDQLDQQFSQIVALFDQVQGFSKFKQDFARFFQEMQAETPLKMSVVTLAYTIYTLISELIDFGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5L8</accession>
    <name>A0A1W1I5L8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dipeptide epimerase</fullName>
            <ecNumber evidence="5">5.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_2132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4 5">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the mandelate racemase/muconate lactonizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2132"/>
    <dbReference type="EnsemblBacteria" id="SLM48304">
        <property type="protein sequence ID" value="SLM48304"/>
        <property type="gene ID" value="NSJP_2132"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2132"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016855">
        <property type="term" value="F:racemase and epimerase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03319">
        <property type="entry name" value="L-Ala-DL-Glu_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034603">
        <property type="entry name" value="Dipeptide_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="7">
        <location>
            <begin position="177"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for (R)-substrate epimerization" evidence="3">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for (S)-substrate epimerization" evidence="3">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR634603-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR634603-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM48304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="401" mass="43884" checksum="087A5EBB949FA16E" modified="2017-06-07" version="1">MEVKSVAPESPHNRLTSSVHPGNMTPTHVYHMPTESIAIHRVEFWPIDVPMTDPFVVATGVRLTAENIFVRVTLSNGLQGYGEAAPFPEVGGETRDSCLSALRRLAEHVITKRVDRFVHLAGILKDDQPYQPAARCGLETAMVDAYCRSLEIPMWKLWGGADVRMRESDITIPICDLAKTIDLGRYWYGRGFRLFKMKVGKDVEEDIRRVEALHRILGGIAFIGDGNQGFSRHECSAFVKGVQRFGGALTLLEQPLPRNDLEGLAAIRRDTGIPVAADESVRSLADAHRVVLNHAADFINIKIMKTGLVEAQEIAAYTLSSGLRLMAGGMLETRVAMGCSFGLVLGIKGFEVLDLDTPLLLANDPVTGGYRYEDARLAPWLGPGLDLSVPPSSTAAVIERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5M0</accession>
    <name>A0A1W1I5M0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48231">
        <property type="protein sequence ID" value="SLM48231"/>
        <property type="gene ID" value="NSJP_2059"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2059"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="57" mass="6212" checksum="12885D02B139BD35" modified="2017-06-07" version="1">MFTTTHHSGCKAYTRGLDHDLTDVAQPQVPIASGTMPHGIRGTCCPRTSDVLYHEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5N5</accession>
    <name>A0A1W1I5N5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2134"/>
    <dbReference type="EnsemblBacteria" id="SLM48306">
        <property type="protein sequence ID" value="SLM48306"/>
        <property type="gene ID" value="NSJP_2134"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2134"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025985">
        <property type="entry name" value="YnbE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13617">
        <property type="entry name" value="Lipoprotein_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="71" mass="7836" checksum="A25A0351EE51F36C" modified="2017-06-07" version="1">MTTNSRTRHSAAVRWALIGMMVCASGCTPRVEVAAPEKPITINLNVKIDHEIRVKVDKELDRVLSSDSGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Y0</accession>
    <name>A0A1W1I5Y0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative soluble pyridine nucleotide transhydrogenase</fullName>
            <ecNumber evidence="5">1.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sthA</name>
        <name evidence="5" type="ORF">NSJP_2179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2179"/>
    <dbReference type="EnsemblBacteria" id="SLM48351">
        <property type="protein sequence ID" value="SLM48351"/>
        <property type="gene ID" value="NSJP_2179"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2179"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003957">
        <property type="term" value="F:NAD(P)+ transhydrogenase (B-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="4"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="345"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="468" mass="50775" checksum="A79A89699643F8AA" modified="2017-06-07" version="1">MSRYDLLVIGTGPAGQKAAVQAAKLGKKVGIVERKVVVGGVCINTGTIPSKSLREAVLYLSGFRQRSIYGADYRLKTAITIEDLAFRTNHVIKNEIGIVENQMTRNRVDMIYGTASFVDSHRLRVTQAGGGSVEFEADFIVIAVGSEPAKPDDVPFDHESIIDTDELLTLKHIPQSIVIVGGGVIGTEYASMLAALGVPVILIDKRPRLLEFVDAEIIDALQQQMKEIGVTLYHNEEVVSIHKQQDGLIHVQLRHAGPIAAATLMYAIGRVGATQDLNLGAVGITPDARGRVSVNEHFQTAIPHIYAVGDVIGFPALASTSMQQGRHASCHAFGAPDGTDTELLPYGIYSIPEISMVGRNEEDLAKADIPYGIGIARYREIARGQIIGDETGLLKLLFHRQTRQLLGVHAIGEGATELIHIGQAVMAYRGQINYFVDTVFNYPTLAECYKVAALDGINRLPRPWVPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I600</accession>
    <name>A0A1W1I600_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">apt</name>
        <name evidence="12" type="ORF">NSJP_2276</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2276"/>
    <dbReference type="EnsemblBacteria" id="SLM48448">
        <property type="protein sequence ID" value="SLM48448"/>
        <property type="gene ID" value="NSJP_2276"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2276"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="27"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM48448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="174" mass="18848" checksum="CFE25ACEF7C5774F" modified="2017-06-07" version="1">MTVDQYRSLIREVPDFPRAGILFYDITTLLKDPAAFAAIADELTAYYQGQGISKVVGIESRGFIYGGTLAQRLKAGFVPVRKPGKLPAAIYEVNYELEYGSNSLAIHRDAIVKGERVLIVDDLLATGGTAAATVMLIKQLGGEIAGLDFLVELQSLNGRDKLAGYPVHSTILYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I654</accession>
    <name>A0A1W1I654_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Mechanosensitive ion channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_2283</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2283"/>
    <dbReference type="EnsemblBacteria" id="SLM48455">
        <property type="protein sequence ID" value="SLM48455"/>
        <property type="gene ID" value="NSJP_2283"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2283"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="559"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="194"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM48455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="763" mass="85553" checksum="CBC8768965CB596E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I662</accession>
    <name>A0A1W1I662_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmG</name>
        <name evidence="5" type="ORF">NSJP_2325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2325"/>
    <dbReference type="EnsemblBacteria" id="SLM48497">
        <property type="protein sequence ID" value="SLM48497"/>
        <property type="gene ID" value="NSJP_2325"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2325"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM48497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="49" mass="5968" checksum="F9C3C48EA9F091ED" modified="2017-06-07" version="1">MREIIDLACTTCKQRNYSTNKNKKNDPDRLERNKFCKFCRKHTPHKEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I678</accession>
    <name>A0A1W1I678_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">rpsC</name>
        <name evidence="12" type="ORF">NSJP_2344</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2344"/>
    <dbReference type="EnsemblBacteria" id="SLM48516">
        <property type="protein sequence ID" value="SLM48516"/>
        <property type="gene ID" value="NSJP_2344"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2344"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="11">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM48516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="223" mass="25338" checksum="DD1377A1E0743EA0" modified="2017-06-07" version="1">MGQKTHPIGYRLGYNYTWSSRWYAEKDYAKLLHQDIKIRKIVKQKLFHAGVAKVEIERSGDQTRVIIHTARPGIIIGRKGAEVDKLKAELEKQYGGQVYITVKEIKKPELDAQLVSENVATQLEKRVAFRRAMKRSVQSALRLGAQGIKIMIAGRLGGAEIARTEWYREGRVPLHTLRAEVDYGFAEAHTTMGQIGVKTWIYKGEILPAQPLKPESAFERRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I699</accession>
    <name>A0A1W1I699_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpsH</name>
        <name evidence="6" type="ORF">NSJP_2352</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2352"/>
    <dbReference type="EnsemblBacteria" id="SLM48524">
        <property type="protein sequence ID" value="SLM48524"/>
        <property type="gene ID" value="NSJP_2352"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2352"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="131" mass="14490" checksum="119FEDF1CFD16752" modified="2017-06-07" version="1">MVTDPISDLLVRLRNGFRRQHEVVTMPASKLKREVLRVLQAEGFIHGVEGAEEEGHPVLKVRLRYVGEGQPMITGMERVSKPGRRVYVGNKNIPRVRNGIGMAILSTSKGIMTDQASRKAGLGGEVLCSIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6E9</accession>
    <name>A0A1W1I6E9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48413">
        <property type="protein sequence ID" value="SLM48413"/>
        <property type="gene ID" value="NSJP_2241"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2241"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="262" mass="29745" checksum="E4394AF49B2CBF9E" modified="2017-06-07" version="1">MAEIMVLTLFILLLIVAVALERHRKELERNADTINKQRQEIKNLLVFQKVVTDNPNGVVVKDIVQQLSRQKEDIARLEAEAQQRSPTESSVRAFETLVSALTKESNGKATDQQIRDKIKETSAVMKESETLKGQIAQLRSQIKASGRGNEFPSCWVTTPEGKIESIFELLMSETGIRIIERPLPHRAEDKAKLPLSAIRYNTEYPRYEFEALMRPLYEWSVAHECRFYVITASSELSAPISLVNAINGYFYPDGKIHLRTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6M2</accession>
    <name>A0A1W1I6M2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RimK domain protein ATP-grasp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2453"/>
    <dbReference type="EnsemblBacteria" id="SLM48625">
        <property type="protein sequence ID" value="SLM48625"/>
        <property type="gene ID" value="NSJP_2453"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2453"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="112"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="292" mass="32364" checksum="7A6A3020EE802F26" modified="2017-06-07" version="1">MADPVLANVCARLAVRNADLMLVHPDADGDTWNLSWAIEDGCVSDRIGLGNRIVRGSDIESVYLRAMTSRDTSMQAARMAVTSLWEFAESLPVLVVNRRQASHTNMSKPYQLQLIERYGFRVPKTLVTMVPEQARAFYDECGGRVIYKSISSERSIVKRLTPDDFARLDLVRECPTQFQEMIPGTDLRVHTVGDRLFATEVVSDGVDYRYAADEGGRRSMRAVELPPAIHARCLDLVGGIGLSLSGIDLRRTPDGSYYCFEVNTSPAFTLFENHTGQRIGDALADLLLTGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6P7</accession>
    <name>A0A1W1I6P7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ypfJ</name>
        <name evidence="7" type="ORF">NSJP_2492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48664">
        <property type="protein sequence ID" value="SLM48664"/>
        <property type="gene ID" value="NSJP_2492"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2492"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007343">
        <property type="entry name" value="Uncharacterised_pept_Zn_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30168">
        <property type="entry name" value="PTHR30168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04228">
        <property type="entry name" value="Zn_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="289" mass="31175" checksum="CE770C7C9DF2FD21" modified="2017-06-07" version="1">MRWEGQQDSQNVEDRRGMGPARIGGVGGLGLGGIVLVLAVSYFTGTNPLALLEMLGGIQNMSPESSQETGPTGPPSDELGKFASVVLADTERTWGQLLPALGRSYEDPRLVLFTGAVQSACGTASSAVGPFYCPGDRKVYLDLSFFNELSQRLGAPGDFAQAYVIAHEVGHHVQNLLGTAERVTRLQRQASETEGNALSVRMELQADCFAGVWGHHANRERNLIEPGDFEEGLRAAGAIGDDQLQRTSHGHVRPESWTHGSSEQRMTWLRRGLESGDPRACDTFAGKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6T8</accession>
    <name>A0A1W1I6T8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48695">
        <property type="protein sequence ID" value="SLM48695"/>
        <property type="gene ID" value="NSJP_2528"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2528"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="27" mass="3323" checksum="626B5C7F974EDFC0" modified="2017-06-07" version="1">MCLRHWSLLFPQLWLLGQRLFFYGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7E0</accession>
    <name>A0A1W1I7E0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48927">
        <property type="protein sequence ID" value="SLM48927"/>
        <property type="gene ID" value="NSJP_2760"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2760"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="198" mass="22001" checksum="33BAD74DCAE6776C" modified="2017-06-07" version="1">MIVHWLKGPAADMFRAGRSLFTPGFLIACLLSVWTACLPFPACAVPMVNDPKGFEGIPWGAAFSETPEFLLVENGAHIKGYELQQGPPDLGTAKVDSMRFLTFDGQFARVVIRYHGQETHERIVSYFQSLYGPLDRTPGQISKGPVQQLNWQGDDSEIILTYEGMKDRGIIFFEHRPSALKFSEGQMAPEQDLGGATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7K8</accession>
    <name>A0A1W1I7K8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Transcriptional regulator ModE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2830"/>
    <dbReference type="EnsemblBacteria" id="SLM48997">
        <property type="protein sequence ID" value="SLM48997"/>
        <property type="gene ID" value="NSJP_2830"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2830"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12727">
        <property type="entry name" value="PBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="391" mass="42617" checksum="4FC5D8E55A936C34" modified="2017-06-07" version="1">MGIKHRAESVDHFRNELKNLRNARGLSQGELASRAGITRQAVSSIESNLYLPTTAVALRLAAALSCRVEELFSLIRPVERIQGTLVGRVPERDPSRPPVRVKVAQVGSRIVVRPVMGLGDVLSCAVGADGYLTEPASYSDGSTVEVMLSRDRQAVEQEISVAGCDPAIFLAGEHMRRRKDQTSVVGWTMGSMAALRSLQRGEVHVAGLHLFDPATGESNLPFVRRALKGSAYDVVTFATWEEGLLVRKGNPKSIRTAADLAEPTVTLLNREEGAGARLLLDRQLREAGIDPARVRGYDRIASSHFEVARAIAGQQADVGIGIRAAAQYFELDFVPLQSARYDLVVPKAYLTSHPTLAHLFETIVSRQFRNEIEALGGYDTTQTGTMHVLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7S6</accession>
    <name>A0A1W1I7S6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49044">
        <property type="protein sequence ID" value="SLM49044"/>
        <property type="gene ID" value="NSJP_2877"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2877"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013162033" evidence="1">
        <location>
            <begin position="34"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="145" mass="16024" checksum="28374CBAA6BE8DC2" modified="2017-06-07" version="1">MDQRRTVPRSHPILASLLMLAALVGCSSKPAHYESKWPLVPIQNLNTVVGEWQGVVMKERRVVPAGEVKLMIRENGTYLFVGQTASDMVLGTGNVEVRDGRLEGGSDLRTITGTLHDKKGKPLLFIVAANRQTGDRFHGEFTRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I811</accession>
    <name>A0A1W1I811_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">valS</name>
        <name evidence="13" type="ORF">NSJP_2973</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2973"/>
    <dbReference type="EnsemblBacteria" id="SLM49140">
        <property type="protein sequence ID" value="SLM49140"/>
        <property type="gene ID" value="NSJP_2973"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2973"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="33"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="662"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Val_tRNA-synt_C" evidence="12">
        <location>
            <begin position="866"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="581"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM49140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="936" mass="106466" checksum="5722BC6515E7F16C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I847</accession>
    <name>A0A1W1I847_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49101">
        <property type="protein sequence ID" value="SLM49101"/>
        <property type="gene ID" value="NSJP_2934"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2934"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="43" mass="4508" checksum="02607A0086D005A8" modified="2017-06-07" version="1">MSALTVDYIIGLLKTYAAQTGDSVDVLLVGAMALQAYGYQAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I860</accession>
    <name>A0A1W1I860_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_2944</name>
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    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
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            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49111">
        <property type="protein sequence ID" value="SLM49111"/>
        <property type="gene ID" value="NSJP_2944"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2944"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="63" mass="7021" checksum="9CB02B339F365717" modified="2017-06-07" version="1">MVSRPGAGLDSHKGLGATGVEQQIEEEGGENTKFECRNSKWESQNTKRESQSSKRETRNLNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I864</accession>
    <name>A0A1W1I864_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
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            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="NSJP_3023"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3023"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010740838" evidence="2">
        <location>
            <begin position="30"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="237" mass="24632" checksum="EC25E54A00320783" modified="2017-06-07" version="1">MQPRLHSFSTLIAAGIFLVLIALAGVATAEQPTSIAQTTESVPFTPEQDAPPPTTGEIRERGTSLDPVVTLQPRRIAVRSITISIITTALLTGGLVSVPLAPRLLAGELPSQTPSPARDREAEKDTGAQETAPVPREEKGPMTGPGDVQERAIRQGTGAPGESPVCACVSPAGQCVFSAVHGCVPSQGPVGCAGGCFEEKPQLGNVRPSVLPKSNAPVLQRRGVEIEKPLSSEKEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8C4</accession>
    <name>A0A1W1I8C4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3083</name>
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    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49250">
        <property type="protein sequence ID" value="SLM49250"/>
        <property type="gene ID" value="NSJP_3083"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3083"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="156" mass="17492" checksum="D95722B284E82EBD" modified="2017-06-07" version="1">MTDYLTSFYLENTLRVIEHRKAQRLFDEQQIILHHNTDDLEDMVKLGRMAGAGYVVFGDATIAVPRSAYVNSGYDVTVLVREISVETSQIMWAGQAKYPVAVPEPEQAVVNGTYWAIQVALCSAEKGSTWEQPPVGCKKQTDSSPESRLSVPRRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8G4</accession>
    <name>A0A1W1I8G4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Nitrospira</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49338">
        <property type="protein sequence ID" value="SLM49338"/>
        <property type="gene ID" value="NSJP_3171"/>
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        <property type="component" value="Chromosome i"/>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF4112"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="149" mass="15592" checksum="C89EBACEA7030324" modified="2017-06-07" version="1">MVAAAEALATLLDSSVKIPGTPWYLGLDPIIGLIPGIGDLLANLIGLTIVGLAARLHVPRIVLARMGLNLLINGAVGSIPVAGDLFSVWFRSHARNARLLRAAATSPSRPTGGDWLYVGSIIGIMFILLALAIALVVWSLVMIWHAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8X2</accession>
    <name>A0A1W1I8X2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxygen sensor histidine kinase NreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">NSJP_3289</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49456">
        <property type="protein sequence ID" value="SLM49456"/>
        <property type="gene ID" value="NSJP_3289"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3289"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CheY-like_superfamily"/>
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        <property type="entry name" value="HATPase_C"/>
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        <property type="entry name" value="HATPase_C_sf"/>
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        <property type="entry name" value="His_kinase_dom"/>
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        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
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        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
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        <property type="entry name" value="HATPase_c"/>
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    </dbReference>
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        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
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        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="11" id="KW-0408">Iron</keyword>
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    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0597">Phosphoprotein</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
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        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="77"/>
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="121"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="189"/>
            <end position="211"/>
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        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
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        <location>
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            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="19">
        <location>
            <begin position="446"/>
            <end position="538"/>
        </location>
    </feature>
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        <location>
            <begin position="564"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="16">
        <location>
            <position position="615"/>
        </location>
    </feature>
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        <source>
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            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="SLM49456.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
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    </evidence>
    <sequence length="692" mass="75327" checksum="DF30CC3D96A603AA" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I967</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name type="scientific">Nitrospira japonica</name>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="SLM49481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="67" mass="7581" checksum="94CFC8E05B1709A8" modified="2017-06-07" version="1">MDQQHTAADQILQAVKAHPDCALGHLIRSLPELSWFEVFHEVDRLGRTGRIKFSRNSLGLATTLRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I992</accession>
    <name>A0A1W1I992_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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        <property type="gene ID" value="NSJP_3385"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="18"/>
            <end position="34"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="60" mass="6857" checksum="6B2C4897C854B16C" modified="2017-06-07" version="1">MECPKCKGLMMLERFSDFFLIFYAWKCINCGAIIDRTISNNRRKSLAARDAQPSTPVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9A2</accession>
    <name>A0A1W1I9A2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
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            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="NSJP_3216"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3216"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
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        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="112" mass="12437" checksum="FA7F7102A89D1717" modified="2017-06-07" version="1">MMVHSDKRRSLRVPITCAVYYSDGAFHASGVTANLNHSGGCLQGSHNVAVGMELMVLLIPPTQSALLIRKATVRWVRDQFFGVQLDHNDTATSWELDQVAFDQRTPLSLMTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9F5</accession>
    <name>A0A1W1I9F5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3477"/>
    <dbReference type="EnsemblBacteria" id="SLM49644">
        <property type="protein sequence ID" value="SLM49644"/>
        <property type="gene ID" value="NSJP_3477"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3477"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="243" mass="25127" checksum="342C055017C76F9E" modified="2017-06-07" version="1">MRSVRANHLKYWPVGAHNLSVHDRAYRISRLGIALAATAAFCSLLGCNDMSKAPPPDPVPGELAIATTFLPDGDVGEPYVAAVGGSGGITPYKWSVSPALPPSLTFDQTSGSISGTPTTAATTTHTFTLQDSSNPADTVQKSLSLTVEPPLLVNTTSLPVGRVNVPYPVTTLTAVGGLPPLVWQPVAMPFGLTFDPASHSILGTPLTSGTTSVTFTVRDSSSPFNKTASATLGLTIAPSLTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9I0</accession>
    <name>A0A1W1I9I0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Adenosylcobinamide amidohydrolase</fullName>
            <ecNumber evidence="1">3.5.1.90</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.90" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3530"/>
    <dbReference type="EnsemblBacteria" id="SLM49697">
        <property type="protein sequence ID" value="SLM49697"/>
        <property type="gene ID" value="NSJP_3530"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3530"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043756">
        <property type="term" value="F:adenosylcobinamide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002808">
        <property type="entry name" value="AdoCbi_amidolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01955">
        <property type="entry name" value="CbiZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="235" mass="25260" checksum="0FD19BF1912F6FE3" modified="2017-06-07" version="1">MLDTLVLRLGGMYRVLSSAPGGGGLVRARSILNHQVAANPMTSGRRTVWASKAMSDWQDPARFLGALADRLGVERPVVGLMTAVPMTRLVHRREEKEGIWVECFCTVGVANAVRAGEPVRRDANTRGRRRDGTINIILVTNATLTGSAMVGAVQVATESKTAVLIRRCIPSAASHGTATGTGTDAVVVASNGFGGHKIRYSGTHTQIGSMIGRLVARCVEEGLTRWFRWRRTSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9M4</accession>
    <name>A0A1W1I9M4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49569">
        <property type="protein sequence ID" value="SLM49569"/>
        <property type="gene ID" value="NSJP_3402"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3402"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="121" mass="14179" checksum="77F357A9AD69C09C" modified="2017-06-07" version="1">MPKNWIEKHQLAGLDERERGFSRPVELEQADPGYRAHLQYEDLRLSTGWCPVRDAVLPALTDMLQSRGYRQLKTQMTFRGESYLGSQEPWVEYPDPPQESVTSGGWLDSLMYWFRTRTARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9R0</accession>
    <name>A0A1W1I9R0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
            <shortName evidence="1">DHPS</shortName>
            <ecNumber evidence="1">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">folP</name>
        <name evidence="3" type="ORF">NSJP_3569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHPS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3569"/>
    <dbReference type="EnsemblBacteria" id="SLM49736">
        <property type="protein sequence ID" value="SLM49736"/>
        <property type="gene ID" value="NSJP_3569"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3569"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="2">
        <location>
            <begin position="16"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="287" mass="31030" checksum="28909D7ADF40B87F" modified="2017-06-07" version="1">MELHAGDRVIRWREHPLVMGILNVTPDSFFDGGRFIDPQVAVAHAVQMVEEGADLLDIGAESTRPGSNPVDEAEERRRLIPVVAAVAKVVAIPISVDTSKAAVAQAAIDAGAVIVNDVTALRGDPAMPDVIARNRSGVVLMHMQGTPRTMQQAPGYRNVVEDVSAFFEERLRCAADKLISRSRIILDPGIGFGKLLLDNLDLLAGLRTFSQFDCPVLVGVSRKAFLGKLTDRPVDDRVWGTAAAVALAVEHGARILRVHDVQAMRDVVKVATAIARRPHASLREQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9R3</accession>
    <name>A0A1W1I9R3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49661">
        <property type="protein sequence ID" value="SLM49661"/>
        <property type="gene ID" value="NSJP_3494"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3494"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="139" mass="15641" checksum="DD79B782060CDEF9" modified="2017-06-07" version="1">MKPVMQEEPTGCGIAAVAAIAGVSYGRAKRVAGSAGIVAADPRLWSDHGHVRRLLSRFGMRSGRSPQPFRSWNALPPCALLAIKWRLQDGHPSWHWTVYVADEHGTYVLDSKRGLKTHVRRDFGRMKPKWFLPVRRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9T2</accession>
    <name>A0A1W1I9T2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Permease, YjgP/YjgQ family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_3514</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3514"/>
    <dbReference type="EnsemblBacteria" id="SLM49681">
        <property type="protein sequence ID" value="SLM49681"/>
        <property type="gene ID" value="NSJP_3514"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3514"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030923">
        <property type="entry name" value="LptG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04408">
        <property type="entry name" value="LptG_lptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM49681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="363" mass="40757" checksum="32C8E9BEEFB42E99" modified="2017-06-07" version="1">MTILFRYLLREYAKIFGMCFAGLMTIYLVIDFFEKVRRFLRYDASWLDVLSYFALKVPGISYQIAPLAILMATLLTLGLLSRSHEITAMRSCGISLPRITSPFLTLAMGLAMVLLLFSSTVIPLASNKAEEIRAIRIEKKSPATALRLPQPWARMGADTILQVKSVAVGGGSLSGVRLFHFDPQFHLIDMTEAQEARYVDQAWTLHQGFRRIFHPDGAIVLQPFERMPVPLTLIPEDFTTWLASDSESMTFRDIREHITRLYHSGSQITRLKTDYYGRIAFPFVTIIMVLVGIALSLRRSGTRGGSMAIGIGQALVIGFLYWTTHSISIAFGRGGAIPPILAGWLTNALFLSYGLYLMLKVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9T5</accession>
    <name>A0A1W1I9T5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Histidine kinase</fullName>
            <ecNumber evidence="9">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_3641</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3641"/>
    <dbReference type="EnsemblBacteria" id="SLM49808">
        <property type="protein sequence ID" value="SLM49808"/>
        <property type="gene ID" value="NSJP_3641"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3641"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007895">
        <property type="entry name" value="MASE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05231">
        <property type="entry name" value="MASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="369"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="605" mass="65392" checksum="5B859646D65200E2" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9U2</accession>
    <name>A0A1W1I9U2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Methylamine utilization protein MauG</fullName>
            <ecNumber evidence="10">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mauG</name>
        <name evidence="10" type="ORF">NSJP_3650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="6">Binds 2 heme groups.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Binds 2 heme groups per subunit.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49817">
        <property type="protein sequence ID" value="SLM49817"/>
        <property type="gene ID" value="NSJP_3650"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3650"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004852">
        <property type="entry name" value="Di-haem_cyt_c_peroxidsae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026259">
        <property type="entry name" value="MauG/Cytc_peroxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03150">
        <property type="entry name" value="CCP_MauG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000294">
        <property type="entry name" value="Cytochrome-c_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="9">
        <location>
            <begin position="66"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="9">
        <location>
            <begin position="219"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="6">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="6">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000294-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM49817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="356" mass="39209" checksum="3F11EA70449B2E46" modified="2017-06-07" version="1">MLNRLTLGCILAAVLSLPGETRIPTASAEPLAACTAVSTPYQLKIPFGLEDDVKQYLPADNPLTVEKVELGKLLFFDSRLSRDNTISCASCHKPELAWTDGTKLSMGIGNQLSSRNSMTVINRLYGRAQLWHGKMATLEDQAKNPLTKAVRMGMPTADEEVAKLNAIKGYRERFQKVFCTNATMDGIAKAIAAFERTILSGNSPADRFDMGGEDTAISESAKRGLAVFQGKGRCTRCHSGFNFSDEEFHNLGIDWDRNSADLGRYSVERHPGTVGGFKTPTLREIARTAPYMHDGRFATLEEVVEFYDQGGITNPHLSNLIIPLRLTAQEKKDLVEYMRALNGDGWQVAGPTEFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9V6</accession>
    <name>A0A1W1I9V6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3613"/>
    <dbReference type="EnsemblBacteria" id="SLM49780">
        <property type="protein sequence ID" value="SLM49780"/>
        <property type="gene ID" value="NSJP_3613"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3613"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="336"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="653" mass="74377" checksum="AACA535F187E7CCB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9X6</accession>
    <name>A0A1W1I9X6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49806">
        <property type="protein sequence ID" value="SLM49806"/>
        <property type="gene ID" value="NSJP_3639"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3639"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012641933" evidence="2">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="67" mass="7532" checksum="0356499558DFBDB0" modified="2017-06-07" version="1">MIRILCTLSLTLMAGAMIIGCANDPSDRNRPSHNLDMRSPQSGQYRFDERPPASSMDPYSRSQPGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA33</accession>
    <name>A0A1W1IA33_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3688"/>
    <dbReference type="EnsemblBacteria" id="SLM49855">
        <property type="protein sequence ID" value="SLM49855"/>
        <property type="gene ID" value="NSJP_3688"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3688"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="202" mass="22787" checksum="A3848A89FA3A3DF5" modified="2017-06-07" version="1">MSHARSTREIRSARPGDISGILELQTEYFVGNLDREARKGGFISSTFTRRQFEEIAQDVALLVAAEHTRIVAYLCAASGDYYRQFPLLEALRQRASDMIYLGRRLDSYRSFIYGPVCIARLQRGRGLLGDLFEQLLRVVPTAYDIGIALISKDNRPSFEAHVRKLGMTAVGDYEFGDHRYDVVAFTVPRAPHQSPVESPRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IA98</accession>
    <name>A0A1W1IA98_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49926">
        <property type="protein sequence ID" value="SLM49926"/>
        <property type="gene ID" value="NSJP_3759"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3759"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="42" mass="5002" checksum="328E8537552D070B" modified="2017-06-07" version="1">MRKQTLDVFKKNYVHLEKHDLRGCDSWRREQPVEATDIGSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAC7</accession>
    <name>A0A1W1IAC7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49871">
        <property type="protein sequence ID" value="SLM49871"/>
        <property type="gene ID" value="NSJP_3704"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3704"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="226" mass="25221" checksum="04C82EC64EDCC4E4" modified="2017-06-07" version="1">MTRTDPRTDPVLGLSLVQVVLLLVFAVLLVQVTDNGANGQPDTRQSAAVPESVSQSAAQSDALPPTTESTRTDPGLQAKLDDAAETSRRLEKRLAEVTALVDEVKGMVGAKAASRDGFQEAVENMKRGYTLCQKDNVLIEASIQNGEESIRVIGDIPSGLDTSLAKGEYTSDLDQIVPFMQDVYQYEKDRKCRFNYRLQYVTDNDYRKARERFEKYFFPEKMTKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAE8</accession>
    <name>A0A1W1IAE8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetyltransf_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FemABX family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49965">
        <property type="protein sequence ID" value="SLM49965"/>
        <property type="gene ID" value="NSJP_3798"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3798"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="2">
        <location>
            <begin position="168"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="353" mass="40700" checksum="EBF64E030638AE23" modified="2017-06-07" version="1">MPDTVVVRLCASEKDFAAWDRYVFDLPGAHFFQTYGWLHSYQSMGFTPHVLVCEINGVIRAGVGFLVTKLPWLPWRIFIIPHGPLPSIPSLQSWSLLMARLDEICVESRAIYAQVYPHELTENSVLLSRLHEIGFTDPPMFGSHRFSSTPVTVDLAGKSEAEVLMTFRPRTRQYIRKSLSSEFELRTTADEATFHKVYELVAQQAMQKGYSARPYASMRSTWEWFAPKGGVSLMQAWWKDTLVGAIYILYTGQTAYYLAGAFRREFSERRPAEFLHWHAILEAMKRRVATYDLVNTVSSGVEQFKRGFRPMEQSWHAPRTKVYRPFLARATRAAEKVLKPIIRTLVRYQADRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAP9</accession>
    <name>A0A1W1IAP9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Activator of Hsp90 ATPase 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3676"/>
    <dbReference type="EnsemblBacteria" id="SLM49843">
        <property type="protein sequence ID" value="SLM49843"/>
        <property type="gene ID" value="NSJP_3676"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3676"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="152" mass="17089" checksum="812DA1D1BDC2B342" modified="2017-06-07" version="1">MANIMHKIGIKAPLFKVYAALSTVEGIAGWWTKDTSSSSKVGEQIRVRFLSTAGKEIGSMAMDVVALEPNRKVQWRLTAGPEEWLDTEVIFNLSQDGDYTIVLFGHNNWREANEFTAHCSMKWATFLLSLRELVETGKGKPSPNDTKIDNWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAS3</accession>
    <name>A0A1W1IAS3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50138">
        <property type="protein sequence ID" value="SLM50138"/>
        <property type="gene ID" value="NSJP_3971"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3971"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="429" mass="46433" checksum="31B9677F78AE989A" modified="2017-06-07" version="1">MFCRAMAEWVRPAVFLNVLIVSGVSILVSVFGTSSHSLAQATLSAPADLRVFDTPNDAGQNLTVLWAPGSSDGPESRYQVLAGDGGSSDPSTLKVVAEFPANSHFVRDAKAPWWTRSAEPSWHQFIIKSGKEIELKDGHVYAVTVALVRGDQRGVGTILQASPHPDWFNWNQTNNLLVALGFGVLVFYTIRHAKRKDIFLRRIAGLDAVDEAIGRSTELGKPILYLTGAHDMSDPSTIAAAVILGRVAKKTAAYETELMVPHRDPITMAVCQEITKQAYLEAGKPDLFKDDSNFFITSDQFSYTAAVDGIMLRKKPAANFFMGSFFAESLLLTETGASTGAIQIAGTDSDHQLPFFVTTCDYTLIGEELYAASAYLSKEPIQIGTLRGQDIGKAVILSAIAIGTVVATIGVATGAHWPRLILDLLRDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAT2</accession>
    <name>A0A1W1IAT2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Iron dicitrate transmembrane sensor FecR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_3939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3939"/>
    <dbReference type="EnsemblBacteria" id="SLM50106">
        <property type="protein sequence ID" value="SLM50106"/>
        <property type="gene ID" value="NSJP_3939"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3939"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032623">
        <property type="entry name" value="FecR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16220">
        <property type="entry name" value="DUF4880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="DUF4880" evidence="2">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="1">
        <location>
            <begin position="144"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="350" mass="38422" checksum="318D9BBAAA12A4D6" modified="2017-06-07" version="1">MTVGDSWDRWSVIQGKGIVGSPMPNREPRAFSTTKSTAEHVLTREATEWFVRLGAPKVSTTEREAFEHWRSQSDAHARAFREVTSLWNEIELETAAADACRSIPDSARESAWPWSWQWATAAALVLICGYAVLFSDLWLRWQADVSTVVAEQRSVELPDHSTAFLNSDSAIALDFTGATRVVRLLKGEVLFTVRSDPDRPFIVKSGSSMTRAVGTAFVVRSRGSDAVVTVTKGIVEVSKGGASSAPVWVERGQQVSTNAGGVGAVEAVDLDVATAWVQGRLVFVRSQLSDVLDEVRRYYPGYVLLLSSDAGRVPVTGIYKVSDPAHVFATLAESLQMKMTRFSDRLIILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB02</accession>
    <name>A0A1W1IB02_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Type 11 methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50194">
        <property type="protein sequence ID" value="SLM50194"/>
        <property type="gene ID" value="NSJP_4027"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4027"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="118"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="360" mass="40587" checksum="BE38A6E380F6C36F" modified="2017-06-07" version="1">MHTSQKCDSRSAVADYIAFCCPECKGTLSKRPNAYHCEACNRNYPIQDGIGCFSDLATYHGEVPKPLMATILKDSERLGYKKAFQQHIQDPFIYKYVDDESRSLWISIIPHGQESTFLDVGCGWGTNAAPISQEVGAVVALDATFERVKFVQIRCRQDKKFNVTPVLGSAIKLPLPDNSVDVVAFNGVLEWLGGIDTSRNPVELQQLALREARRVLKAGGHVYIGIENRFSLRYMLGDQDDHSFLRFTSLMPRVIANVYCRLRTGGPYFTYTHSLSEYHRLIREAGFSKVKSYFPWPDYRNPTAIVTLGREPVAEQLSAILNGGVKPSFRQRIYLSLLKFLTSFEGKGRLCHSFCFVASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB15</accession>
    <name>A0A1W1IB15_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_4008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4008"/>
    <dbReference type="EnsemblBacteria" id="SLM50175">
        <property type="protein sequence ID" value="SLM50175"/>
        <property type="gene ID" value="NSJP_4008"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4008"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="207"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="268" mass="29743" checksum="6643FA54FB01B37C" modified="2017-06-07" version="1">MVTGMKLIGRKICACERLVRLGAGVVLFLVALSNAACGELEPMAEPEVVDLQLSIDTLKTQVRDTQRTITELRAELDVRRQELADAQVARAQLEGRVREAERRVAEAKQVIELQREELMTARAERERLSRSSLQLHSQLKRLQKHLSKSGMSKDGIQDVLPAFREGSGRKAQKTAMVATPAALMGTSVDYDDMASDRDFSYGEPAPRTVFVKYGDTLWSLAKRHHVSLHQLREINQLSGNAIEIGQALRLPEGRRGRASVPGVPESIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB24</accession>
    <name>A0A1W1IB24_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 2</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_4033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4033"/>
    <dbReference type="EnsemblBacteria" id="SLM50200">
        <property type="protein sequence ID" value="SLM50200"/>
        <property type="gene ID" value="NSJP_4033"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4033"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="45"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM50200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="376" mass="42367" checksum="F8A2CEC44453D0D0" modified="2017-06-07" version="1">MEALFWLSVWFIGYAYAGYPLCLYTVGLFRSRPVRKSEFRPTVAVIITAYNEEKRIREKLENTLKLEYPREKLELIVASDCSTDATDDIVRSFASSGIRLVRSNVKGGKEAAQKLAVESTIGDVLVFSDTATILEPTAISEIVNNFSDGTVGCVSSVDRFIDTDGVVSGEGAYVRYEMALRSLESRVNTLVGLSGSFFSARREVCRSWAPDLQSDFNTLLNSIRLGLRGVADPDSIGYYKNLADQKKEYERKVRTVVRGISVFMRSLPLLNPMRYHLFAWQLLSHKLCRWLVPFAMIGALVSNLVLAASSPFYQATLLVQVLFYVLACLYLLTQQLPNIGVLRIPSFFVMVNISILDAWIRYLRGERIVSWSPSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB27</accession>
    <name>A0A1W1IB27_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Transcription antitermination protein RfaH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_4071</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4071"/>
    <dbReference type="EnsemblBacteria" id="SLM50238">
        <property type="protein sequence ID" value="SLM50238"/>
        <property type="gene ID" value="NSJP_4071"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4071"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NGN" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM50238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="167" mass="19318" checksum="6D223B4129A1C6A2" modified="2017-06-07" version="1">MEKWYAIMAKPKQEYTTTSVLRQVGIDTYYPEIREVFNIRGQRRTRPAGLFPGYFFAKFDYDRQYRIVSYCRGVRKIVMFGSFPAEVESSLLDEIKIRLERTHTIHLPSFKPGEIVQINHGPLAGIKGIFGSSLPSKERVVVLLRTLLYQSRAVIQLSDIEKFPEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB37</accession>
    <name>A0A1W1IB37_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Low molecular weight protein-tyrosine-phosphatase Wzb (Modular protein)</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_4028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4028"/>
    <dbReference type="EnsemblBacteria" id="SLM50195">
        <property type="protein sequence ID" value="SLM50195"/>
        <property type="gene ID" value="NSJP_4028"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4028"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="3">
        <location>
            <begin position="52"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="202" mass="23228" checksum="93C80D5E7309DFEA" modified="2017-06-07" version="1">MSATGVAWFKRGIQSYFHGLREAGRHTYRNLRILRVFSERIMTPRALPHPVRNVLFVCARNLCRSPLAEAYFRDKARKESVLISVSSAGIETLPGRPAHSLAREVAGQFGVSLESHAAKQLYQKLLDQSDLILVMEMSQRERLARLYPRERQKIFVLGRFCSTGPLDIADPHRGSREDFRICFERIKDSCDRLIEKLTQARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB47</accession>
    <name>A0A1W1IB47_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NGN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NSJP_3826</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3826"/>
    <dbReference type="EnsemblBacteria" id="SLM49993">
        <property type="protein sequence ID" value="SLM49993"/>
        <property type="gene ID" value="NSJP_3826"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3826"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NGN" evidence="5">
        <location>
            <begin position="10"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="181"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM49993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="211" mass="24405" checksum="55BE56A3A3FDADED" modified="2017-06-07" version="1">MQSEAEQVDDRRWFALQTRSRHEKVVRDELLRRDIENFLPLMTRLRQWTDRKKKIEFPLFSGYCFARFSLDARLPVLQTTGVVRIIGRNGRPESIPAPEIESLMIVMNNRAQYQYAVHPFLKEGMLVEVVSGPFQGVKGRVVRQDKHCRIVISISLIQQAVAVEIDASCIVPVSTGDVLPESNQHQPYHYSGLSRDRSPDRYNERFGSHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB59</accession>
    <name>A0A1W1IB59_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucosyl-3-phosphoglycerate synthase</fullName>
            <ecNumber evidence="1">2.4.1.266</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpgS</name>
        <name evidence="1" type="ORF">NSJP_3836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.266" evidence="1"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50003">
        <property type="protein sequence ID" value="SLM50003"/>
        <property type="gene ID" value="NSJP_3836"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3836"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM50003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="416" mass="47035" checksum="282AA4D803734824" modified="2017-06-07" version="1">MVLSDFYQNGVVTVLHRLGPSNVAQLERELARHGSTHPIALVLPCLYAELARPALRHILDTLSGLSYLNEIVVSLDRASALEFRLAKQYFSALPQRVRLIWNDGHRIQSLLKLFVAKNLDIGHPGKGRGCWMAFGYILARNESQVIALHDCDIASYSREYLARLCYPIANPNLNYEFCKGYYSRVTDRLHGRVTRLFITPLIRSLQQLVGPHPLLTFLDSFRYPLAGEFAMVRDLAWTNRIPGDWGLEIGVLAEIYRNCALRRICQADIADTYDHKHQPLSDNDADTGLLKMCVDITKSLFRNLASEGVVLSDSVLKTLRATYVQSAQEAINRYENDAAINSLMFDRHEERTAVEVFLQGMKLATEGFLDDPLGVPMISNWSRVTHAIPDVFDRMIEAVEEDHAWDPTAEPAVTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB86</accession>
    <name>A0A1W1IB86_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthetase</fullName>
            <ecNumber evidence="9">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_4131</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50298">
        <property type="protein sequence ID" value="SLM50298"/>
        <property type="gene ID" value="NSJP_4131"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4131"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="386"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM50298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="671" mass="76134" checksum="6D848129B9891045" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBN8</accession>
    <name>A0A1W1IBN8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mobile element protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_4016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4016"/>
    <dbReference type="EnsemblBacteria" id="SLM50183">
        <property type="protein sequence ID" value="SLM50183"/>
        <property type="gene ID" value="NSJP_4016"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4016"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="100"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="211" mass="24548" checksum="D5D2A5AC5CD9312C" modified="2017-06-07" version="1">MTVTGLPIQRACRAMGLGRATYYRPVVDWARRDAPVIAALTTLVAAKSRWGFWKCYARLRLDGQPWNHKRLWRVYCQLRLNLPRRTKKRLPMRLRQPLVVLPQPNAVWAVDFMSDTLYGGRRFRTVNVLDEGVREALAIEIDTSLPAERVIRVLEQVVAWRGRPQALRLDNGPELIADRFLTWCAERGIELRYIPPGKPDQNAFIERFNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IBZ6</accession>
    <name>A0A1W1IBZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide biosynthesis protein CapD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_4126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4126"/>
    <dbReference type="EnsemblBacteria" id="SLM50293">
        <property type="protein sequence ID" value="SLM50293"/>
        <property type="gene ID" value="NSJP_4126"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4126"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_2" evidence="3">
        <location>
            <begin position="300"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="635" mass="70209" checksum="EE0D402462C4C51D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZL8</accession>
    <name>A0A1W1HZL8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0012"/>
    <dbReference type="EnsemblBacteria" id="SLM46184">
        <property type="protein sequence ID" value="SLM46184"/>
        <property type="gene ID" value="NSJP_0012"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0012"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="57" mass="6281" checksum="D4B16C0E4CD8AAF8" modified="2017-06-07" version="1">MVPWPGSRGLFLWGSPLIVPRTAGPEELEAKRVELEDALNRLTAEADDIMTPRPHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZT2</accession>
    <name>A0A1W1HZT2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-binding protein SmbP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">smbP</name>
        <name evidence="2" type="ORF">NSJP_0083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46255">
        <property type="protein sequence ID" value="SLM46255"/>
        <property type="gene ID" value="NSJP_0083"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0083"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13840">
        <property type="entry name" value="SMBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031877">
        <property type="entry name" value="SmbP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16785">
        <property type="entry name" value="SMBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012641931" evidence="1">
        <location>
            <begin position="27"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="113" mass="11883" checksum="59DCCEEDA7F4369D" modified="2017-06-07" version="1">MKVTIQRGALLLAAVALLGMPLVAQADNKHVSEAVEHAKEAVEHGKQGHADALTKHAEGALKHAQAAQKDTKNPHLDEGVKHLQEAVEHGKAGHADVATKHAEGAVTHLSEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZV4</accession>
    <name>A0A1W1HZV4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46264">
        <property type="protein sequence ID" value="SLM46264"/>
        <property type="gene ID" value="NSJP_0092"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0092"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="61" mass="7602" checksum="5F133694F6DE4337" modified="2017-06-07" version="1">MKEKRRVLYKKGVFVCPKCRQSYVQEKWIEEWRIRCHKCDYRGTLTEVSVEEHMDEETIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1HZZ0</accession>
    <name>A0A1W1HZZ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative O-methyltransferase, family 2</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_0143</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0143"/>
    <dbReference type="EnsemblBacteria" id="SLM46315">
        <property type="protein sequence ID" value="SLM46315"/>
        <property type="gene ID" value="NSJP_0143"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0143"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031725">
        <property type="entry name" value="ASMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="PTHR11746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16864">
        <property type="entry name" value="Dimerisation2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dimerisation2" evidence="4">
        <location>
            <begin position="16"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_2" evidence="3">
        <location>
            <begin position="150"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM46315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="328" mass="35823" checksum="9B5D9DCC30D12BE8" modified="2017-06-07" version="1">MSRELSLAEIFQLGYYWETKILLTAVRLDLFTALDGKKRTAGEIAVRIGAHEPTLSLLLNALVAMRLLTKDGDLYGNSSVTDKHLVRHSSDFVGHLLLLHDAEWENWGTLEQTIRTGQRSVDRHVFETDPDLGGNVLAVLHRIGRQSGPDFAKRVNLTGTIRLLDLGGGAGTNAIAFCRVYPDLSATVFDLPATLRLTEKTVKEAGLESRISLRAGNFNADGLGGPYDVVLMSDILHYQSFETNAALVRKVFAHLAADGRLIIKDRFLNETGTGPAWTTAFAVHILINTQQGGCYKVTDAIEWMTRAGFVSAVELEPTAVVLGTKGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I055</accession>
    <name>A0A1W1I055_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_0213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46385">
        <property type="protein sequence ID" value="SLM46385"/>
        <property type="gene ID" value="NSJP_0213"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0213"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="59" mass="6282" checksum="CD7F3A5F511664CC" modified="2017-06-07" version="1">MSGVPPTGNKGFGIVFVNGLSLVPNPAAKIIAFINACRPVNCTRSWTEAADSRPRRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0E9</accession>
    <name>A0A1W1I0E9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46323">
        <property type="protein sequence ID" value="SLM46323"/>
        <property type="gene ID" value="NSJP_0151"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0151"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012348134" evidence="1">
        <location>
            <begin position="36"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="374" mass="39951" checksum="DE1C17184CE2BE98" modified="2017-06-07" version="1">MTPASTTAERATIRLAVFTFSAALALILTTCPAHAFKVKEPAEGSSLTAGQTVTAHVDLENDIGIIKVRYYWYREQDETLVQQDEIDSSISKSEAKISVDKFLQKDSVVGGAVVAVPVLVSTGDQDPAFGGALKVPSEAIGPMRLLAVAEISRGRLGTRTVFDEIIVTVDPGAALQNIDFETEKPLLLGREGQLATYGQVDVLGKIFELPVVGEFADGITRPLSTPASGTSYQSSNEKVIRVLQDGMLKIVGNGKTVLTVKNRGKEAALDVTVAVGDEPNEPPVAVAGANRTVRSGAKVELNGLSSRDPEGEALFYAWSQVRGAKVPLLDLNMPRASFVAPFVSEPKLFRFRLRVTDKKGADSLPAFVDVTVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0S9</accession>
    <name>A0A1W1I0S9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NSJP_0438</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0438"/>
    <dbReference type="EnsemblBacteria" id="SLM46610">
        <property type="protein sequence ID" value="SLM46610"/>
        <property type="gene ID" value="NSJP_0438"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0438"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="375"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="608"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SLM46610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="837" mass="91169" checksum="D50580A76CFE4328" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I0U8</accession>
    <name>A0A1W1I0U8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Gluconokinase</fullName>
            <ecNumber evidence="4 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gntK</name>
        <name evidence="10" type="ORF">NSJP_0458</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="4 9"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0458"/>
    <dbReference type="EnsemblBacteria" id="SLM46630">
        <property type="protein sequence ID" value="SLM46630"/>
        <property type="gene ID" value="NSJP_0458"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0458"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="PTHR43442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM46630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="167" mass="18717" checksum="6576B377D22804BB" modified="2017-06-07" version="1">MPTECRVIIVMGVAGAGKTTVGLKLARELNWTFIDGDSFHSRSSIEKMAIGQPLTDADRFPWLDRIRAAIDGWRVEGKRVVLACSLLKAAYRDFVLDGRRQLVQLVYLKASPLLLHERLLHRAGHFMKAPLLESQLETLEEPEDALLLDAADTPEQLIGHIRTALHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I104</accession>
    <name>A0A1W1I104_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM46675">
        <property type="protein sequence ID" value="SLM46675"/>
        <property type="gene ID" value="NSJP_0503"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0503"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="127" mass="13999" checksum="45E6ADA93E2B6167" modified="2017-06-07" version="1">MAAIPRIQGRALAIILFCGLMACTKPHQYIDVTCAKMAGDTLLDREAAIQCQTFRQAEAATAVYNEAALLVKSYRACLEKYEEVPMRAKEYCAQYPKALQEIGLQIKEQPDSSSGRRVIPAASSTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I120</accession>
    <name>A0A1W1I120_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_0515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0515"/>
    <dbReference type="EnsemblBacteria" id="SLM46687">
        <property type="protein sequence ID" value="SLM46687"/>
        <property type="gene ID" value="NSJP_0515"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0515"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007801">
        <property type="entry name" value="UPF0276"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05114">
        <property type="entry name" value="DUF692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM46687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="498" mass="55987" checksum="0D24C6770D9D8605" modified="2017-06-07" version="1">MILTHSPQSAFERRVDRIPSLGVGLSVDCYSPDLFALLDELEGCDLHPAYLELFQATTGMLEEVRRRLPAMPLAYHGEGLWVTQPDFPVSPYLKTRLEETVRQLNSIQSHWLNHECASKEMGGFAFGTYLPPLYTATSADVVADNIALVQRALDVHWETTPHGSPLFLLEMAPLTYFSAGDLAVPQFFRRVTDRVACGLVLDIGHLWTVYRYGSVGQHGPLDQFVERFLDEFPLERVVEIHVAGLAERDADVVSDAAAAHPAWIDAHEAEIPSVLWDLLEQTLAHPKLRHLRAVALEVDNKDVALIANEFRLADRRFHGQVASTMTRDPRRTRQDDGGSESVVRQSAVTQQERKGLEKQYVRYARTASGLLSPSGPEWQAVQEDGAGLARYTAGYLPNEILRWGGQLTDMFPDTCRLLAEAGIVLDEFVPWWFRDVRVASESYDFFLLKISRFQEFVCERAPQLSPLADREAALLRSAYADANERRSPAIETDGELTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I159</accession>
    <name>A0A1W1I159_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutaminyl-tRNA synthetase</fullName>
            <shortName evidence="8">GlnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">glnS</name>
        <name evidence="12" type="ORF">NSJP_0564</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="8"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0564"/>
    <dbReference type="EnsemblBacteria" id="SLM46736">
        <property type="protein sequence ID" value="SLM46736"/>
        <property type="gene ID" value="NSJP_0564"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0564"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00126">
        <property type="entry name" value="Gln_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022861">
        <property type="entry name" value="Gln_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="28"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c_C" evidence="11">
        <location>
            <begin position="342"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="269"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="35"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="41"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="262"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="270"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM46736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="564" mass="64179" checksum="37ACC3B1ABDB35BB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I171</accession>
    <name>A0A1W1I171_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yfhJ</name>
        <name evidence="1" type="ORF">NSJP_0576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0576"/>
    <dbReference type="EnsemblBacteria" id="SLM46748">
        <property type="protein sequence ID" value="SLM46748"/>
        <property type="gene ID" value="NSJP_0576"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0576"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007479">
        <property type="entry name" value="ISC_FeS_clus_asmbl_IscsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036762">
        <property type="entry name" value="IscX-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37532">
        <property type="entry name" value="PTHR37532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04384">
        <property type="entry name" value="Fe-S_assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039003">
        <property type="entry name" value="IscX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140319">
        <property type="entry name" value="SSF140319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03412">
        <property type="entry name" value="iscX_yfhJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM46748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="70" mass="8338" checksum="162E5A435B5A984F" modified="2017-06-07" version="1">MDLRWQDTEDIAIRLVEEHPDTDPLTVRFTDMHAWIVALPDFKDDPKKSNEKILETIQMAWHEEFKDSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I1V1</accession>
    <name>A0A1W1I1V1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_0631</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM46803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0631"/>
    <dbReference type="EnsemblBacteria" id="SLM46803">
        <property type="protein sequence ID" value="SLM46803"/>
        <property type="gene ID" value="NSJP_0631"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0631"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="92"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM46803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="236" mass="27383" checksum="2EFAA2F164151D24" modified="2017-06-07" version="1">MQVAFDQFDDERFSFHEDQVLILDQVWSAADRLEFQRAMREAPWTSLRDNSRLAVTFPYCGNWLKADLMHSQRRRLLDRLSLSCITRYIESFPNIAGRHVNFNYYSYAAGDCLRTHDDIAQDQASADMMLRPTPMRRLAMVTYLHDEWEPDWGGELVIYDMGEGRRDQSVFTVTHCIPPKPGSLVLFTVPRYHRVCRIDELCGAAKRLSIAGWFMTEHQPCTITTAALQQVCAPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I270</accession>
    <name>A0A1W1I270_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative Peptidase M50</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NSJP_0899</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_0899"/>
    <dbReference type="EnsemblBacteria" id="SLM47071">
        <property type="protein sequence ID" value="SLM47071"/>
        <property type="gene ID" value="NSJP_0899"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_0899"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044838">
        <property type="entry name" value="EGY1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31412">
        <property type="entry name" value="PTHR31412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="9">
        <location>
            <begin position="213"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM47071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="325" mass="35141" checksum="71BF2A39BD6CFDF2" modified="2017-06-07" version="1">MEPVDGHQSIPFTDREDSRRGAGPVAPTDEPDLDAADEPSVFSQWILPLLLLCLTIFTTLWAGAYQAYSGMVGGPVDFLLTHPAGLWKGVPFAGTLLFILVTHELGHYVLSKIHRVPASLPLFIPGPPHFIGTFGAIIRMRGPILNRRALFDIGVAGPLAGFVVAVIALIIGLGFSQVVDRNATFGLQLGEPLLLQFLSWVVIGSLPPEADVVLHPVAFAAWFGLFVTSLNLIPIGQLDGGHVAYALWGPRQRTMAFAIVPVLIVLGFVGWPGWFVWAFMAGLWGLGHPPVRNPNVPLGTARMIVGWLTLLVFVVTFAPIPFSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I2M1</accession>
    <name>A0A1W1I2M1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1086"/>
    <dbReference type="EnsemblBacteria" id="SLM47258">
        <property type="protein sequence ID" value="SLM47258"/>
        <property type="gene ID" value="NSJP_1086"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1086"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="149"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM47258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="285" mass="30748" checksum="0F710A3F9BF6E5F3" modified="2017-06-07" version="1">MKVVIGVDWSEEAFASVRQVFELYRPTEVTLVHGIDLGIFEYPVLAQTASVPGYEDFARAVTDAGHQVLDRAADLLPDGLNTVKKINETGQPAELIRRSAITMQADLVVVGARGRSRLTEVFLGSVSHRVVTQADRTTLIVKGAVKPVRRILVAVEGQEDAARIVPWLQAHPFVHPVEVCVLNVQEPVRPVDPYHTGIFQDWAAAEKTAAEDVVKTVGAALVASHGSVSTRVATGDVAETIAAEAQDRDLVVVSSHGRRGVDRLLMGSVSHAILHRVTGSVLVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I315</accession>
    <name>A0A1W1I315_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47398">
        <property type="protein sequence ID" value="SLM47398"/>
        <property type="gene ID" value="NSJP_1226"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1226"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="118" mass="13025" checksum="5F2AC6D3EC426CDD" modified="2017-06-07" version="1">MLIETSLPLILLIPSGELRLKAGQFVDLPDEQAKRLIEKAAGKVRVVSLSKPVMIQSPLRQPRSVYWERADGSIAGPAEPEILECVEVGSQESFWVVVQYEGVPVWISSAVLRTDRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3F5</accession>
    <name>A0A1W1I3F5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1352"/>
    <dbReference type="EnsemblBacteria" id="SLM47524">
        <property type="protein sequence ID" value="SLM47524"/>
        <property type="gene ID" value="NSJP_1352"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1352"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="1">
        <location>
            <begin position="70"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM47524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="290" mass="31597" checksum="A2414175D150312C" modified="2017-06-07" version="1">MSTRRAIILRHLRALAHERHPDAAPQALRQAAEYLADEFSGLGWATTRRTFHARGRTFDNILAACVERRERQAAAPLLIGAHYDTVVGSPGADDNASGLVVLLELADALRKVQLPRPVWLAAFNLEEEGLLGSKTFADELRRAKQPFGGAIILECVGYAVNKEGSQRKPPGIPIAVPTVGNFLGIVGNEASHGLADAMARSAKHRVPALETLTMIVPGRGEQLPDTRRSDHAAFWDAGFPAVMLTDTANFRNPHYHRPTDEIETLNLDFLERVAAAVAAMAQLPVERDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I3S3</accession>
    <name>A0A1W1I3S3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_1484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM47656">
        <property type="protein sequence ID" value="SLM47656"/>
        <property type="gene ID" value="NSJP_1484"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1484"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM47656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="106" mass="12278" checksum="ED006C461184D3A5" modified="2017-06-07" version="1">MSKTVKVDITMYGIAEVLHWCQDRNKGRIAGVDTAGFEKMKTFLGEKPQSGDYFTLDQFWKKRVTLDLTEDEVALIDRCLYDIPNLDNEPLPQIRHKFWPKQAATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I491</accession>
    <name>A0A1W1I491_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative C32 tRNA thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ydaO</name>
        <name evidence="7" type="ORF">NSJP_1517</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1517"/>
    <dbReference type="EnsemblBacteria" id="SLM47689">
        <property type="protein sequence ID" value="SLM47689"/>
        <property type="gene ID" value="NSJP_1517"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1517"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01850">
        <property type="entry name" value="TtcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012089">
        <property type="entry name" value="tRNA_Cyd_32_2_STrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="6">
        <location>
            <begin position="48"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="292" mass="32751" checksum="6195DE2F1EAEC159" modified="2017-06-07" version="1">MRPMPHSPDRAAFASKFDEATERLQIHLLRQVGQTIGDYGLIEADDRVMVCLSGGKDSYGLLDLLLVLQKKAPIRFELIAVNLDQKQPGFPAQVLPEYLTALGVPFHIEARDTYSIVKRLIPEGQTTCSLCSRLRRGHLYRIAGELGATKIALGHHRDDVLETLLLNLLFTGKLKTMPPKLLSKDKRHVVIRPLAAVREADLARYAELRGFPIIPCDLCGSQPNLKRKEVKEFLRNWEQRIPGCTDSMFAALSNVAPSLLLDRRLFDFSSLDLSEDGGNQDAWLDEEHETSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4A6</accession>
    <name>A0A1W1I4A6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Peptidase S49, signal peptide peptidase SppA</fullName>
            <ecNumber evidence="4">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_1481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="4"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1481"/>
    <dbReference type="EnsemblBacteria" id="SLM47653">
        <property type="protein sequence ID" value="SLM47653"/>
        <property type="gene ID" value="NSJP_1481"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1481"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004635">
        <property type="entry name" value="Pept_S49_SppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00706">
        <property type="entry name" value="SppA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="3">
        <location>
            <begin position="108"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM47653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="302" mass="32679" checksum="AE097C0DA4CBB603" modified="2017-06-07" version="1">MNATMNQGTGEPAGRWPLRRKILWGVLGVMGLMFFINTFFPDLDLSAEDRIALVRVEGVILDSQSTVTELKRFGENPSIKAIVLRIDSPGGGVVPSQEIYDAVQRVRNKNSKAVIASMGTVAASGGYYIASATDRIIANPGTLTGSIGVIMETANVEGLLKKIGVEGIVVKSGKFKDVGSPLRRMSDEERALLQSVMDDVHKQFIEAVASGRAMEPAAVQALADGRIFTGRQAKEAKLVDELGNLEDAIQLAADLAGIEGEPKVVEPRRRFSIRELIESRLTAVLPKLDFYSGVSLKYLMAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4J0</accession>
    <name>A0A1W1I4J0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">ychF</name>
        <name evidence="7" type="ORF">NSJP_1756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM47928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1756"/>
    <dbReference type="EnsemblBacteria" id="SLM47928">
        <property type="protein sequence ID" value="SLM47928"/>
        <property type="gene ID" value="NSJP_1756"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1756"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="3"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="278"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM47928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="363" mass="39918" checksum="75779CC7C45CC973" modified="2017-06-07" version="1">MGLCCGMIGLPNVGKTTVFNALTGSGALAANYPFATVDPNTGIALVPDPRLLTLTDIFKSKKTTYSTLEVRDIAGLVEGASKGEGLGNQFLGHIREVDALLHVVRCFSDSDVVHVAGRVDPLRDIGVIETELMLADLEALDRRKQKTEKKVRAGDKKAAFEMDFLARLIGMLDKGEWLGNLAYQPEERALLDECQLLSAKPVLFVANVSEGQQADEARVEAVREFAARRGARVVRICGQFEAEVSSLAEAERADFLKEMGLSESGLVRLTREAYALLNLITFFTAGEIESRAWPIVKNTKAPQAAGKIHSDMERGFIRAEVYTYDDLLAHGSEAKVKEKGLFRLEGKDYVIKEADIVYFRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4Q6</accession>
    <name>A0A1W1I4Q6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">smc</name>
        <name evidence="6" type="ORF">NSJP_1835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1835"/>
    <dbReference type="EnsemblBacteria" id="SLM48007">
        <property type="protein sequence ID" value="SLM48007"/>
        <property type="gene ID" value="NSJP_1835"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1835"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="5">
        <location>
            <begin position="530"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="965"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="176"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SLM48007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="1217" mass="134893" checksum="AA5E7E3D8FFC0CAC" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I4V5</accession>
    <name>A0A1W1I4V5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_1876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48048">
        <property type="protein sequence ID" value="SLM48048"/>
        <property type="gene ID" value="NSJP_1876"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1876"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012212959" evidence="1">
        <location>
            <begin position="31"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="2">
        <location>
            <begin position="301"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="803" mass="89022" checksum="3F128C071C1DA136" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I519</accession>
    <name>A0A1W1I519_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_1924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_1924"/>
    <dbReference type="EnsemblBacteria" id="SLM48096">
        <property type="protein sequence ID" value="SLM48096"/>
        <property type="gene ID" value="NSJP_1924"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_1924"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011460">
        <property type="entry name" value="DUF1566"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07603">
        <property type="entry name" value="DUF1566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012484080" evidence="1">
        <location>
            <begin position="22"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM48096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="172" mass="19238" checksum="6457356F65F3FA79" modified="2017-06-07" version="1">MLKRFLGSMGIILACTMPSFAVPLESWDDKIPNGSQRFKVLSEFNDEAVLDKETQLVWERAPYSLSFIWKDARGSCPFKIIGGRRGWRLPSFVELMSLVDPTANASPLLPPGHPFSNIHAVPGDFYWSATTSADVTTDAWEVFFGQGTTGPGDKMQMHFVWCVRGPMNADQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5G6</accession>
    <name>A0A1W1I5G6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphomethylpyrimidine synthase</fullName>
            <ecNumber evidence="10">4.1.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Hydroxymethylpyrimidine phosphate synthase</fullName>
            <shortName evidence="10">HMP-P synthase</shortName>
            <shortName evidence="10">HMP-phosphate synthase</shortName>
            <shortName evidence="10">HMPP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thiamine biosynthesis protein ThiC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">thiC</name>
        <name evidence="13" type="ORF">NSJP_2080</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:24840"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.99.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ThiC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.17" evidence="10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2080"/>
    <dbReference type="EnsemblBacteria" id="SLM48252">
        <property type="protein sequence ID" value="SLM48252"/>
        <property type="gene ID" value="NSJP_2080"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2080"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00089">
        <property type="entry name" value="ThiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037509">
        <property type="entry name" value="ThiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025747">
        <property type="entry name" value="ThiC-associated_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="PTHR30557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13667">
        <property type="entry name" value="ThiC-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ThiC-associated" evidence="12">
        <location>
            <begin position="19"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="350"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="391"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="578"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="581"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="586"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SLM48252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="629" mass="69596" checksum="7EC34687B330A7F5" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I5Z6</accession>
    <name>A0A1W1I5Z6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48424">
        <property type="protein sequence ID" value="SLM48424"/>
        <property type="gene ID" value="NSJP_2252"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2252"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="58" mass="6577" checksum="954EAD89686B2A2F" modified="2017-06-07" version="1">MRAWNPQGWLRIIAQALIAVRRTGRSQARISLPAHYTQADRRLLRGNDRDLPAQGGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6E1</accession>
    <name>A0A1W1I6E1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NSJP_2404</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2404"/>
    <dbReference type="EnsemblBacteria" id="SLM48576">
        <property type="protein sequence ID" value="SLM48576"/>
        <property type="gene ID" value="NSJP_2404"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2404"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="159"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SLM48576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="350" mass="37911" checksum="7CE7F507DCDADA81" modified="2017-06-07" version="1">MESTNDAMVSETASPAGRTGEPPRIMVRSLTHRVGESLKRAGMSAVRSVHVKGGTSGGRAAGNPWFISVFVLVMFLLAWHFFTLRPTFDPIGLTEEQLQLMEFNGDIVRTPEGAYVWNPEKEKVKGIPGPLAVVEKARTELAEAFVKKGTNDHGIGYLVLYTVSRFGAGFLAASVIAILLGVVLGLNKVLYRAANPFIQILKPISPLAWMPLLLYTVKDPKWTAMLVVFMAAVWPTLATTAFGVSSLKKEYLHVASIVQLSWFKRLFKVILPGAAPTIVNGLRISFGSALVAVVPAEMLLGELGVGYLSWIEWNNLDIAGVIFAILVVGVVGVVLDSGFNKLAGLVTYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I6J9</accession>
    <name>A0A1W1I6J9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenylosuccinate lyase</fullName>
            <shortName evidence="10">ASL</shortName>
            <ecNumber evidence="4 10">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">purB</name>
        <name evidence="12" type="ORF">NSJP_2442</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2442"/>
    <dbReference type="EnsemblBacteria" id="SLM48614">
        <property type="protein sequence ID" value="SLM48614"/>
        <property type="gene ID" value="NSJP_2442"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2442"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="11">
        <location>
            <begin position="349"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SLM48614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="445" mass="50089" checksum="62F5FC07B7607B57" modified="2017-06-07" version="1">MIDRYTRPGMKAIWDLKHKYEIWLEVELQACAAFERAGQAPRGTAARIRRKARINVKRIAKIELVTKHDVIAFLESLADDVGPEHRFLHMGLTSSDIVDTSLAMQLTEALDLILDGVEGFQKVLKDQALRHKRTVTVGRSHGIHGEPISFGFKLAIWYEEIGRHLERLRQVRGIIAVGKLSGAMGTFAHQGPEIEAYVCSKLGLSVDPVSNQVVQRDRHAAFATALALLAATIEKIATEIRHLQRTEVLEAEEYFSQGQKGSSAMPHKRNPIVSENLCGLARLVRANSLAAMENVALWHERDISHSSVERVIMPDSTILVDYMLAKVTDLIARLVVYPERMKRNLELTGGLVYSQRLLLALVAKGAQRKESYEAVQRNAMASWQGAGMLQDLAAKDPFIARHLKRSEIAACFDPRYYLRHLDQVFRRVFRGPGRRRGAQRKRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I717</accession>
    <name>A0A1W1I717_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2627"/>
    <dbReference type="EnsemblBacteria" id="SLM48794">
        <property type="protein sequence ID" value="SLM48794"/>
        <property type="gene ID" value="NSJP_2627"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2627"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="95" mass="11316" checksum="D00D3AA7657AD126" modified="2017-06-07" version="1">MVERVMLIRHKERKFGRGCVQEWISHRGSLSVKFSELLIPLDHILRRSSFLLSDRPLFVDYDLYGVLSNYLFSGKTKFPNLKNLRRWFRAMSKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7S4</accession>
    <name>A0A1W1I7S4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48971">
        <property type="protein sequence ID" value="SLM48971"/>
        <property type="gene ID" value="NSJP_2804"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2804"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013207076" evidence="2">
        <location>
            <begin position="30"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM48971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="387" mass="43289" checksum="A4AFCE7047967956" modified="2017-06-07" version="1">MMKTFLRSLLTATYLLVLFQVFRPTLASAQPQGDVFSSQGAYDNFAVGGAHRWYDKHSADAKQKSSHCLSILDEAKAIQETALALDKEARQPGIDSRQATALRKQANEQFALRDKDIRAFIDCFNQANRQKSPRSDQFATSGEPPSPTGGKKQPGEKSSHPSETRRDQGQKQASASIPRTDHRGQETPSDIFSTTGDKTPSDELQTQSPSDEKSIKRTPRPPDGITAKANDSTLKKAIDGCLQEYLPFYDTDWDRLTPESAGVKSSEALQRSFYLSGIAADQVISFVQARYGNESDRELTPDYLIGWLTNCLMDRKVLPRQEPRILYRRYMEGHDPLNINKKRITERFEQFGYGGRLYPSIPPFRDHDSSTTSSSGSLPTTPRANMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7S9</accession>
    <name>A0A1W1I7S9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_2696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM48863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM48863">
        <property type="protein sequence ID" value="SLM48863"/>
        <property type="gene ID" value="NSJP_2696"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2696"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM48863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="64" mass="7071" checksum="A9D4D5CDFE3203B2" modified="2017-06-07" version="1">MMSGYQTCCAITHLVMGEDKMSRNPDSDTESEVGQLFGGTVKRNTEPWWVISIICAWTEIGGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7T6</accession>
    <name>A0A1W1I7T6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2887"/>
    <dbReference type="EnsemblBacteria" id="SLM49054">
        <property type="protein sequence ID" value="SLM49054"/>
        <property type="gene ID" value="NSJP_2887"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2887"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010621">
        <property type="entry name" value="DUF1214"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037049">
        <property type="entry name" value="DUF1214_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010679">
        <property type="entry name" value="DUF1254"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037050">
        <property type="entry name" value="DUF1254_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06742">
        <property type="entry name" value="DUF1214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06863">
        <property type="entry name" value="DUF1254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012845471" evidence="1">
        <location>
            <begin position="22"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1254" evidence="3">
        <location>
            <begin position="65"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1214" evidence="2">
        <location>
            <begin position="250"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="352" mass="38627" checksum="8B616DE653D90094" modified="2017-06-07" version="1">MMKAVVGALTIVMVMSVGAHAKSGSPAKSVSPAPAGKPLLVTMDNFIRAESDLYFGNVVKDKGFGRFSHTRQVTPVNKQPIVRMNRDTLYSAAVFDLDAGPVAITLPDSGSRFMSMQVITEDHFTPLVAYKPGSYALTREDIDTRYVLVAVRALVDPTDPNDLDEVHALQDAIKVEQAGSGKFEVPRWDPESQKKIREALIVLGSTLSDSKHMFGTKEQVTPLRHLIGSAVGWGGNPDTEATYLGVTPERNDGNQVYKLTLRDVPVDGFWSITVYNAKGYLEANRYDTYSLNSITAKKRIDGSVTVQFGGCNGKIANCLPIMRGWNYTVRLYRPQPEILSGGWVFPEAQPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7V2</accession>
    <name>A0A1W1I7V2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_2913</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49080">
        <property type="protein sequence ID" value="SLM49080"/>
        <property type="gene ID" value="NSJP_2913"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2913"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="3">
        <location>
            <begin position="42"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="365" mass="40529" checksum="DEDE8B23DF6DD52B" modified="2017-06-07" version="1">MAKRMERRRRPFLWPALAGIALVGMAAGYVWLEGQPPAPIPDGMAWIPGGTFWMGSDDPMFRDAQPVHQVEVDGFFMDRTEVTNEQFEQFVKATGYVTVAERVPRAEDYPGAPPENLVAGSVVFTAPPSPVPLDNHFQWWSYVTGASWRHPEGKESTIDDKMNHPVVHVAYEDATAFATWAGKRLPTEAEWEYAARGGLVKKAYTWGDEFEPDGKTMANSFQGHFPDHNDAHDGFITTAPASSFPPNGFGLYDMAGNVWEWTSDWYRHDYFQTLASAGVARNPQGPRNSFDPSEPGVQKKVHKGGSYLCTDQYCARYRPGGRGKGEPDTGTSHLGFRLVKDAQVGAHKQTKTVAPFDQTSPRRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7V3</accession>
    <name>A0A1W1I7V3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdate ABC transporter, periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">modA</name>
        <name evidence="4" type="ORF">NSJP_2834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2834"/>
    <dbReference type="EnsemblBacteria" id="SLM49001">
        <property type="protein sequence ID" value="SLM49001"/>
        <property type="gene ID" value="NSJP_2834"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2834"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030973">
        <property type="term" value="F:molybdate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13539">
        <property type="entry name" value="PBP2_AvModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044084">
        <property type="entry name" value="AvModA-like_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM49001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="264" mass="28743" checksum="BBD2C9E95B0164B3" modified="2017-06-07" version="1">MNHRRCGIFVTRLTTLALFLIVLVSSAGVTLAEELTIAAASDLSFAFKELAGEFEKSSGHHVKLSLGSSGNFYSQIQNGAPFDLYFSADIGYPRKLEEAGLTVPGSLYRYAIGRIVVWAGHGSRLDMTKGMEVLRESSIKKIAIANPKHAPYGRAAVSSMEHFNLYQQVKDRLVLGENISQAAQFVESGACEVGIIALSLALAPTMKAKGAYWEVPAETHPALEQGAVILKSSQRREAAQEFLEFIKGQTGQEIMKRYGFTIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I7X3</accession>
    <name>A0A1W1I7X3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Surface antigen (D15)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NSJP_2927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_2927"/>
    <dbReference type="EnsemblBacteria" id="SLM49094">
        <property type="protein sequence ID" value="SLM49094"/>
        <property type="gene ID" value="NSJP_2927"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2927"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005565">
        <property type="entry name" value="Hemolysn_activator_HlyB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013686">
        <property type="entry name" value="Polypept-transport_assoc_ShlB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08479">
        <property type="entry name" value="POTRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03865">
        <property type="entry name" value="ShlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POTRA_2" evidence="2">
        <location>
            <begin position="53"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="ShlB" evidence="1">
        <location>
            <begin position="188"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SLM49094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="561" mass="62193" checksum="1A361F85921255F0" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I855</accession>
    <name>A0A1W1I855_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MscS Mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NSJP_2872</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49039">
        <property type="protein sequence ID" value="SLM49039"/>
        <property type="gene ID" value="NSJP_2872"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_2872"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SLM49039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="604" mass="66599" checksum="281072F0D21BCCB2" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8G9</accession>
    <name>A0A1W1I8G9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TonB-dependent receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NSJP_3150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49317">
        <property type="protein sequence ID" value="SLM49317"/>
        <property type="gene ID" value="NSJP_3150"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3150"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="115"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="283"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SLM49317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="755" mass="83100" checksum="3EA395E7A8875EBB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I8K6</accession>
    <name>A0A1W1I8K6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49352">
        <property type="protein sequence ID" value="SLM49352"/>
        <property type="gene ID" value="NSJP_3185"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3185"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM49352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="300" mass="31185" checksum="F0C8BC6016A84CC7" modified="2017-06-07" version="1">MRFQSIGSFTSKPSACGTVALAVMALVAVGCSSTSKIAQSPKGSVHLEEVSDWSFDASHPAVIDQATMMKIVKGLYSDESENGSSRMSAGGSKPMRSFSDEDAEFLTPLLVQGLSKAKPEQIVAFRVSSSAGSGIEPTTGSLYVQKGSVYFTIAKGAKATGFAPESVAHVESAPTYAAGGAAGVIAMVIDYHALAKAPAGSLPVAKPQAKSQATASVASAAGAEQATAQMAAEPVGMDELQQTKEALAKKDVEISMLRKESSWMKRELRDQAEEIKALRASKVSAKPAPAKKRAEANQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I950</accession>
    <name>A0A1W1I950_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49461">
        <property type="protein sequence ID" value="SLM49461"/>
        <property type="gene ID" value="NSJP_3294"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3294"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="67" mass="7879" checksum="8CD65883C35B4CCF" modified="2017-06-07" version="1">MRRGVALPIKKEIQDFIIATEQLYRHLSDARTLTCHEAEILRCCLEELSVIKYRRSPHDGQTVLHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I980</accession>
    <name>A0A1W1I980_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2 7">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">purD</name>
        <name evidence="10" type="ORF">NSJP_3378</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2 7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3378"/>
    <dbReference type="EnsemblBacteria" id="SLM49545">
        <property type="protein sequence ID" value="SLM49545"/>
        <property type="gene ID" value="NSJP_3378"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3378"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="107"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM49545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="426" mass="45374" checksum="EB34342B7C6B92FA" modified="2017-06-07" version="1">MKILVVGSGGREHAIVWTLGQSPRKPTIFCAPGNAGIASLATCVPIAAHDVEALKDFVVRNHIDLTVVGPEVPLALGIADEFRKHRLKIFGPTKGAARLEASKSFSKELMQRAGIPTARAKSFTDAASALAYADQQPLPMVIKADGLAQGKGVMIATNRQQAREAIVDCMEKAVFGEAGKEVLIEEFLDGEELTIMAFTDGRTIVPMPPAQDHKRVGDGDTGLNTGGMGAYAPAPLGTAVLREQVRQQVLEPIVTHLSRIGSPFQGVLYAGLMVVKGVPYVLEFNARMGDPETQVVLPLLKTDLLEVIEAVVEHRLDQIGVEWSKEAAVCVVMTSGGYPGPYRTGVPIRGLSEVPPEHAVIFHAGTAFDQQAVVTAGGRVLGITGLGSDIASAQQTAYRAANALSFDGCHYRRDIAHRALHPRTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9A8</accession>
    <name>A0A1W1I9A8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dioxygenase, ferredoxin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NSJP_3405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3405"/>
    <dbReference type="EnsemblBacteria" id="SLM49572">
        <property type="protein sequence ID" value="SLM49572"/>
        <property type="gene ID" value="NSJP_3405"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3405"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="101" mass="10604" checksum="CB1C984A5A8C6C66" modified="2017-06-07" version="1">MGEFVRVAGSGDIKPGHGIVAEAQGKAIALFNVDGVFHAIDNTCIHRGGPLGEGDVEGEVVTCPWHGWQFNVTTGTCVNNPSGKVEVYQVKVDGSDVKVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9B5</accession>
    <name>A0A1W1I9B5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonuclease D</fullName>
            <shortName evidence="3">RNase D</shortName>
            <ecNumber evidence="3">3.1.13.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rnd</name>
        <name evidence="5" type="ORF">NSJP_3437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'-mononucleotides.</text>
            <dbReference type="EC" id="3.1.13.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.5" evidence="3"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3437"/>
    <dbReference type="EnsemblBacteria" id="SLM49604">
        <property type="protein sequence ID" value="SLM49604"/>
        <property type="gene ID" value="NSJP_3437"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3437"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033890">
        <property type="term" value="F:ribonuclease D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042780">
        <property type="term" value="P:tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01899">
        <property type="entry name" value="RNase_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006292">
        <property type="entry name" value="RNase_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01388">
        <property type="entry name" value="rnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="HRDC" evidence="4">
        <location>
            <begin position="222"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SLM49604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="403" mass="44644" checksum="63010377074C9012" modified="2017-06-07" version="1">MNQSVTTPSEPVYITTRADLERLCHQLQASAELALDTEFVGEESFVPKLELIQIASSGLSAVIDFPAVQADGPLDMFWELIGNPGVNKIVHAGRQDLDLFAVHAGEIPKPFFDTQIAAAMLGFGAQSAYANLVQRIVGTRLAKAHTFTNWSARPLSHDQIAYAAEDVQFLLPIHAHLVRKLSALGRLEWAHEEFARLESVVGEKGRDPLERYQRIRGWEGLKPKYAAVLRDLAAWRESEAKRRNVPRGRVLRDEVLLQLARHPPRTVNELKTLRGVHSSEVERNGEHIVKTVERSLALPPSAWPQVPVERRSEPESVGVVEFLQAVLKARAAEAEIAPTLLATSADIQALVEAREKKSEIALPLLRGWRREVAGNLIQQVLNGEVTVRVSRSGTLLFKPDGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9F2</accession>
    <name>A0A1W1I9F2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF3485 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NSJP_3448</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3448"/>
    <dbReference type="EnsemblBacteria" id="SLM49615">
        <property type="protein sequence ID" value="SLM49615"/>
        <property type="gene ID" value="NSJP_3448"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3448"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013426">
        <property type="entry name" value="EpsH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026392">
        <property type="entry name" value="Exo/Archaeosortase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019127">
        <property type="entry name" value="Exosortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026491">
        <property type="entry name" value="ExosortD_VPLPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014263">
        <property type="entry name" value="Methanolan_biosynth_EpsI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11984">
        <property type="entry name" value="DUF3485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09721">
        <property type="entry name" value="Exosortase_EpsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02602">
        <property type="entry name" value="8TM_EpsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02914">
        <property type="entry name" value="EpsI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04178">
        <property type="entry name" value="exo_archaeo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04152">
        <property type="entry name" value="exosort_VPLPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3485" evidence="10">
        <location>
            <begin position="321"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SLM49615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="526" mass="58409" checksum="2EF247BA775D0F65" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1I9G5</accession>
    <name>A0A1W1I9G5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NSJP_3276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM49443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM49443">
        <property type="protein sequence ID" value="SLM49443"/>
        <property type="gene ID" value="NSJP_3276"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3276"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SLM49443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="55" mass="6434" checksum="66DA3FC717494F74" modified="2017-06-07" version="1">MRRNVSNLRSLKNQLNKSEIRNPKFETITMKEVQVPNGQIPNIKTQKLEMTNPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IAU0</accession>
    <name>A0A1W1IAU0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">proA</name>
        <name evidence="10" type="ORF">NSJP_4000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_4000"/>
    <dbReference type="EnsemblBacteria" id="SLM50167">
        <property type="protein sequence ID" value="SLM50167"/>
        <property type="gene ID" value="NSJP_4000"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_4000"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="9">
        <location>
            <begin position="18"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SLM50167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="443" mass="47762" checksum="604FE0F142883BD9" modified="2017-06-07" version="1">MADKTRDSTLPAEPKEPVEYSEVPEQSAEEYIETLVKRARQASGQLATLSTSVKNRALSAMADALEERSEPILAANEQDLDAFGAAPERKAMADRLRLSPSRISEMADGIREVAKLADPLGETPKMWIRPNGMQVGRVRVPIGVIGIIYESRPNVTADSAALCLKSGNACVLRGGSEAIHSNRAIAAALSEAAEKSGIPSGAIGFITRADREAVPIFLKQDRYVDLIIPRGGESLMRTVAEHSTIPVLKHDAGVCHIYVDDDADAAMADRIALNAKVQRPSTCNAMETLLVHHGIARTWLAGFVEKLSAAKVEVRGCPKTCQLSSLAKPAADDDYGKEFLDLTLAVKVVKNIDEALEHIARYGSHHTEAIVTGNYQKAMRFLREVDASAVLVNASTRLNDGYQFGLGAEIGISTSRIHARGPMGLQELTCSKFVVLGSGQIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB11</accession>
    <name>A0A1W1IB11_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NSJP_3934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="SLM50101">
        <property type="protein sequence ID" value="SLM50101"/>
        <property type="gene ID" value="NSJP_3934"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3934"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
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    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
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        <property type="entry name" value="RNA_pol_sigma_r2"/>
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    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="44"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="142"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SLM50101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="205" mass="23584" checksum="03ABEFBC42608DC8" modified="2017-06-07" version="1">MADFPEMKHSPIEPPRATFCHDLLRFKEGSAGWKMLSYAQIESLFHQYREELTRRLTAMVHSRDTAADLIQETYLKLVRLANTTTVDHPRALLHRIATNLAIDHLRASKSGIVATEPLEAALERPCPIPSQERELIGKERLERFIQVVDTLPPRTREAFLLYRVYEYSYREIATKMGISVSGVDKHIRRAIEHTCASIESLDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1W1IB43</accession>
    <name>A0A1W1IB43_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NSJP_3952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrospira japonica</name>
        <dbReference type="NCBI Taxonomy" id="1325564"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Nitrospirae</taxon>
            <taxon>Nitrospirales</taxon>
            <taxon>Nitrospiraceae</taxon>
            <taxon>Nitrospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Afonso C.L."/>
                <person name="Miller P.J."/>
                <person name="Scott M.A."/>
                <person name="Spackman E."/>
                <person name="Goraichik I."/>
                <person name="Dimitrov K.M."/>
                <person name="Suarez D.L."/>
                <person name="Swayne D.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Genome sequencing of Nitrospira japonica strain NJ11</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LT828648">
        <property type="protein sequence ID" value="SLM50119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1325564.NSJP_3952"/>
    <dbReference type="EnsemblBacteria" id="SLM50119">
        <property type="protein sequence ID" value="SLM50119"/>
        <property type="gene ID" value="NSJP_3952"/>
    </dbReference>
    <dbReference type="KEGG" id="nja:NSJP_3952"/>
    <dbReference type="Proteomes" id="UP000192042">
        <property type="component" value="Chromosome i"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021762">
        <property type="entry name" value="DUF3325"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11804">
        <property type="entry name" value="DUF3325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SLM50119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000192042"/>
        </source>
    </evidence>
    <sequence length="107" mass="11542" checksum="80B652FF75926239" modified="2017-06-07" version="1">MRVMEIALCYNGMLALCLAKPKHYRQLFRALPANTTGWSLRVLGWLAVTGAFVCAVGQNGWSLGPVEWIGTIGVMGLILIFLQPFRPQAAALLGGLFLILAVIDAAN</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>